Digital Commons Network^™

Metabolomic Profiles Of Sleep-Disordered Breathing Are Associated With Hypertension And Diabetes Mellitus Development, Ying Zhang, Bing Yu, Qibin Qi, Ali Azarbarzin, Han Chen, Neomi A Shah, Alberto R Ramos, Phyllis C Zee, Jianwen Cai, Martha L Daviglus, Eric Boerwinkle, Robert Kaplan, Peter Y Liu, Susan Redline, Tamar Sofer

Faculty, Staff and Student Publications

Sleep-disordered breathing (SDB) is a prevalent disorder characterized by recurrent episodic upper airway obstruction. Using data from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), we apply principal component analysis (PCA) to seven SDB-related measures. We estimate the associations of the top two SDB PCs with serum levels of 617 metabolites, in both single-metabolite analysis, and a joint penalized regression analysis. The discovery analysis includes 3299 individuals, with validation in a separate dataset of 1522 individuals. Five metabolite associations with SDB PCs are discovered and replicated. SDB PC1, characterized by frequent respiratory events common in older and male adults, is …

Reply To Ayoub-Charette Et Al Lack Of Biological Plausibility And Major Methodological Issues Cast Doubt On The Association Between Aspartame And Autism Comment On "Fowler Et Al Daily Early-Life Exposures To Diet Soda And Aspartame Are Associated With Autism In Males: A Case-Control Study, Sharon Parten Fowler, David Gimeno Ruiz De Porras, Michael D Swartz, Paula Stigler Granados, Lynne Parsons Heilbrun, Raymond F Palmer

Faculty, Staff and Student Publications

Thank you for the opportunity to respond to the concerns raised by Ayoub-Charette et al [...].

Self-Management Of Coronary Heart Disease Among Middle-Aged And Older Low-Income African Americans, Tina Alfred-Iyamu

Walden Dissertations and Doctoral Studies

Coronary heart disease (CHD) stands out as the predominant cardiovascular condition, exerting a significant toll on both mortality and morbidity. Notably, African Americans (AA) grapple with an alarmingly elevated incidence, prevalence, and mortality rate compared to other demographics within the United States. Extensive research underscores the potential for effective CHD management through self-management practices, though this is notably deficient. This qualitative, phenomenological study delves into the intricate lived experiences surrounding the self-management of CHD among low-income individuals in the middle-aged and older AA demographic. My theoretical framework was the Health Belief Model. Impressively, the study participants exhibited a profound understanding …

Covid-19 Infection Increases The Development Of Stevens-Johnson Syndrome And Toxic Epidermal Necrolysis: A Retrospective Cohort Analysis, Kristen K. Curtis, Meghan M. Dillan, Timmie R. Sharma, Joseph Piktel

Student Scholarship

To the Editor: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) represent a spectrum of severe mucocutaneous reactions characterized by extensive epidermal detachment, most commonly due to medications.1 Some viruses, such as the human immunodeficiency virus, have been found to be an independent risk factor for the development of SJS and TEN, though the mechanism is not completely understood.2 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus identified in late 2019, is most commonly associated with mild respiratory illness. However, cutaneous manifestations, including SJS and TEN, have been increasingly reported during and after COVID-19 infection.3 Therefore, the objective …

Infant Mortality Rates Vary Substantially Across Regions Of The United States, Marissa Merrifield

Population Health Research Brief Series

Infant mortality rates are higher in the United States than in its high-income peer countries. Additionally, infant mortality rates vary within the U.S., with much higher rates in some geographic regions compared to others. This data slice uses data from the U.S. Centers for Disease Control and Prevention to compare infant mortality rates by geographic region in the U.S. between 2017-2021. The results show that the infant mortality rate was the highest in the South and lowest in the Northeast and West.

Assessing The Types Of Juvenile Detention Medical Issues: A Focus On Florida, De’Angelo L. Dean

MUSC Theses and Dissertations

The justice system for young people in the United States has been a source of worry as more people acknowledge the possible adverse outcomes of involvement in the justice system during adolescence. Involvement with law enforcement can lead to various difficulties for young people, such as heightened susceptibility to psychological problems, interruptions in their education, and reduced prospects for achievement in the future. Hence, it is crucial to understand the interplays between the health care for juveniles referred by courts or law enforcement for hospital care to identify opportunities for process and outcome improvements. The interaction between juveniles and the …

Path-Bigbird: An Ai-Driven Transformer Approach To Classification Of Cancer Pathology Reports, Mayanka Chandrashekar, Isaac Lyngaas, Heidi A. Hanson, Shang Gao, Xiao Cheng Wu, John Gounley

School of Public Health Faculty Publications

PURPOSE: Surgical pathology reports are critical for cancer diagnosis and management. To accurately extract information about tumor characteristics from pathology reports in near real time, we explore the impact of using domain-specific transformer models that understand cancer pathology reports. METHODS: We built a pathology transformer model, Path-BigBird, by using 2.7 million pathology reports from six SEER cancer registries. We then compare different variations of Path-BigBird with two less computationally intensive methods: Hierarchical Self-Attention Network (HiSAN) classification model and an off-the-shelf clinical transformer model (Clinical BigBird). We use five pathology information extraction tasks for evaluation: site, subsite, laterality, histology, and behavior. …

Association Of Plasma Ykl-40 With Mri, Csf, And Cognitive Markers Of Brain Health And Dementia, Matthew P Pase, Jayandra J Himali, Raquel Puerta, Alexa S Beiser, Mitzi M Gonzales, Claudia L Satizabal, Qiong Yang, Hugo J Aparicio, Daniel J Kojis, Charles S Decarli, Oscar L Lopez, Will Longstreth, Vilmundur Gudnason, Thomas H Mosley, Joshua C Bis, Alison Fohner, Bruce M Psaty, Mercè Boada, Pablo García-González, Sergi Valero, Marta Marquié, Russell Tracy, Lenore J Launer, Agustín Ruiz, Myriam Fornage, Sudha Seshadri

Faculty, Staff and Student Publications

BACKGROUND AND OBJECTIVES: Higher YKL-40 levels in the CSF are a known biomarker of brain inflammation. We explored the utility of plasma YKL-40 as a biomarker for accelerated brain aging and dementia risk.

METHODS: We performed cross-sectional and prospective analyses of 4 community-based cohorts in the United States or Europe: the Age, Gene/Environment Susceptibility-Reykjavik Study, Atherosclerosis Risk in the Communities study, Coronary Artery Risk Development in Young Adults study, and Framingham Heart Study (FHS). YKL-40 was measured from stored plasma by a single laboratory using Mesoscale Discovery with levels log transformed and standardized within each cohort. Outcomes included MRI total …

Estrogen Signaling In The Dorsal Raphe Regulates Binge-Like Drinking In Mice, Valeria C Torres Irizarry, Bing Feng, Xiaohua Yang, Nirali Patel, Sarah Schaul, Lucas Ibrahimi, Hui Ye, Pei Luo, Leslie Carrillo-Sáenz, Penghua Lai, Maya Kota, Devin Dixit, Chunmei Wang, Amy W Lasek, Yanlin He, Pingwen Xu

Faculty, Staff and Students Publications

Estrogens promote binge alcohol drinking and contribute to sex differences in alcohol use disorder. However, the mechanisms are largely unknown. This study aims to test if estrogens act on 5-hydroxytryptamine neurons in the dorsal raphe nucleus (5-HTDRN) to promote binge drinking. We found that female mice drank more alcohol than male mice in chronic drinking in the dark (DID) tests. This sex difference was associated with distinct alterations in mRNA expression of estrogen receptor α (ERα) and 5-HT-related genes in the DRN, suggesting a potential role of estrogen/ERs/5-HT signaling. In supporting this view, 5-HTDRN neurons from naïve male mice had …

Building Advocacy In The Younger Generation Through The Adopt A School Program Of The University Of South Florida College Of Public Health Activist Lab-A Commentary, Karen Liller, Madison Sanders, Erin Millsapps, Truc Ho, Kanika Chandra, Rolando Trejos

Florida Public Health Review

No abstract required as this is a commentary.

Predictors Of Prior Hiv Testing And Acceptance Of A Community-Based Hiv Test Offer Among Male Bar Patrons In Northern Tanzania, Deng B. Madut, Preeti Manavalan, Antipas Mtalo, Timothy Peter, Jan Ostermann, Bernard Njau, Nathan M. Thielman

Faculty Publications

Community-based HIV testing offers an alternative approach to encourage HIV testing among men in sub-Saharan Africa. In this study, we evaluated a community-based HIV testing strategy targeting male bar patrons in northern Tanzania to assess factors predictive of prior HIV testing and factors predictive of accepting a real-time HIV test offer. Participants completed a detailed survey and were offered HIV testing upon survey completion. Poisson regression was used to identify prevalence ratios for the association between potential predictors and prior HIV testing or real-time testing uptake. Of 359 participants analyzed, the median age was 41 (range 19–82) years, 257 (71.6%) …

Improving Safety And Preventing Falls Using An Evidence-Based, Front-Line Staff Huddling Practice: Protocol For A Pragmatic Trial To Increase Quality Of Care In State Veterans Homes, Princess Nash, Valerie Clark, Eleanor Mcconnell, Whitney Mills, Robert Morgan, Camilla Pimentel, Katherine Ritchey, Cari Levy, A Lynn Snow, Christine Hartmann

Faculty, Staff and Student Publications

Introduction: Falls in nursing homes are a major cause for decreases in residents' quality of life and overall health. This study aims to reduce resident falls by implementing the LOCK Falls Programme, an evidence-based quality improvement intervention. The LOCK Falls Programme involves the entire front-line care team in (1) focusing on evidence of positive change, (2) collecting data through systematic observation and (3) facilitating communication and coordination of care through the practice of front-line staff huddles.

Methods and analysis: The study protocol describes a mixed-methods, 4-year hybrid (type 2) effectiveness-implementation study in State Veterans Homes in the USA. The study …

Dietary Adherence And Cognitive Performance In Older Adults By Nativity Status: Results From The National Health And Nutrition Examination Survey (Nhanes), 2011–2014, Md Towfiqul Alam, Elizabeth Vásquez, Jennifer L. Etnier, Sandra Echeverria

Department of Health Sciences - Faculty Scholarship

Although adherence to dietary guidelines is associated with better cognitive performance, there may be differences by nativity status. This study aimed to investigate the association between adherence to the healthy eating index (HEI) and cognitive performance (CP) among United States (US)-born and foreign-born older adults (60+ years). Data were obtained from the 2011–2014 NHANES (n = 3065). Dietary adherence was assessed with HEI quintiles. CP (adequate vs. low) was examined using word listing (CERAD), animal naming (AFT), and the digit symbol substitution test (DSST). Weighted multivariable logistic regressions were used to examine associations. The US-born participants in higher dietary quintiles …

The Effect Of Safety Management Commitment And Motivation On Compliance Implementing Patient Safety Goals Through A Culture Of Patient Safety, Christy Helvita Manalu, Rina Anindita, Intan Silviana Mustikawati

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

Patient safety culture is the main foundation for patient safety in hospitals. Applying a safety culture in hospitals aligns with the existing safety system to reduce unwanted incidents. In 2021, in a hospital in X East Jakarta, patient safety incidents remained accompanied by a culture that could have gone better, as seen from the frequency of reporting incidents, which is still below the reliability target. This study analyzed the effect of safety management commitment and motivation on nurse compliance in implementing patient safety goals through patient safety culture. This research is a quantitative approach with a sample of 105 inpatient …

Analisis Kelengkapan Resume Medis Dan Ketepatan Koding Layanan Operasi Kanker Payudara Di Rumah Sakit Kanker Dharmais Tahun 2022, Yudi Febriadi, Atik Nurwahyuni

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

The background to this research is that there are still National Health Insurance (JKN) claim files being returned to the Dharmais Cancer Hospital (RSKD) with the most common causes being cases of coding confirmation and medical resumes. RSKD started using electronic medical records (eMR) in 2020. In 2018 research with a sample of 45 medical records, it was found that 2.2% of patients were incomplete in filling out the patient identity column, 91.1% of indications for admission, 44.4% of physical examinations and supporting examinations. 8.9%. In addition, it was found that 17.8% of the main diagnosis coding was inappropriate. In …

The Influence Of Motivation And Knowledge On The Completeness Of Medical Records With Attitude As An Intervening Factor, Junaedi Junaedi, Supriyantoro Supriyantoro, Intan Silviana Mustikawati, Ericko Ongko Joyo

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

Incomplete medical record filling by doctors is still a widespread problem encountered in various hospitals. Incomplete medical record documentation is very detrimental to the hospital. This research aims to determine the correlation between motivation and workload on doctors' completeness of medical record filling through attitude mediation. This study was conducted with a cross-sectional design, which included 40 doctors who worked at the inpatient ward of Annisa Citeureup Hospital as the respondents. Motivation, knowledge, and attitudes were assessed using a questionnaire with a Likert scale, while the medical records completeness data was obtained by directly evaluating the medical records. Partial least …

Analisis Produk Layanan Rs Apung Nusa Waluya 2 Menurut Cara Bauran Pemasaran, Ivan Reynaldo Lubis, Hilda Melissa, Indah Pratiwi Suwandi, Irfan Rohot Uli Manik, Wahyu Sulistiadi

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

Hospitals as health service institutions are essential for society. However, in Indonesia, hospitals are not always available in areas far from regional or city government centers. Floating hospitals are an alternative that plays a significant role in island countries such as Indonesia. Even though the number of floating hospitals is very limited, marketing strategies through a marketing mix are still needed for their development, whether assessed from a business or non-business perspective. This study used a descriptive-analytical approach by collecting data from observations and collecting literature as the discussion material. As a result of simple observations and analysis, this study …

Efficiency In Hr: Lean Management With E-Sep And Auto Closing System In Pasar Minggu Hospital, Melanie Husna, Prima Syahputra

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

The study focuses on enhancing efficiency in outpatient transactions at Pasar Minggu Hospital, which, in 2019, experienced a high volume of visits primarily covered by national health insurance. With 299,041 outpatient visits using national health insurance that year, the hospital's transition to a COVID-19 referral facility in 2020 underscored the urgency of streamlining operations. Presently, outpatient transactions are manually closed by three staff members, led by the financial administrator, who handles Participant Eligibility Letter files, resolves transaction issues, and finalizes services. Given the imperative for digitization accelerated by the pandemic, the study adopts lean thinking, employing a value stream map …

Clonal Gene Signatures Predict Prognosis In Mesothelioma And Lung Adenocarcinoma, Yupei Lin, Bryan M Burt, Hyun-Sung Lee, Thinh T Nguyen, Hee-Jin Jang, Claire Lee, Wei Hong, Robert Taylor Ripley, Christopher I Amos, Chao Cheng

Faculty, Staff and Students Publications

Malignant pleural mesothelioma (MPM) is a rare but lethal pleural cancer with high intratumor heterogeneity (ITH). A recent study in lung adenocarcinoma has developed a clonal gene signature (ORACLE) from multiregional transcriptomic data and demonstrated high prognostic values and reproducibility. However, such a strategy has not been tested in other types of cancer with high ITH. We aimed to identify biomarkers from multi-regional data to prognostically stratify MPM patients. We generated a multiregional RNA-seq dataset for 78 tumor samples obtained from 26 MPM patients, each with one sample collected from a superior, lateral, and inferior region of the tumor. By …

A Longitudinal Look At Student Attitude, Perceived Competence, And Fitness Test Performance Of Elementary Students, Risto Marttinen, Kevin Mercier, Jung Yeon Park, Kelly L. Simonton, Erin Centeio, Kevin Andrew Richards, Kathleen Wilson

International Journal of Physical Activity and Health

The purpose of this study was to assess relationships between students’ attitudes toward physical education (PE), their perceived competence toward PE, and their fitness test performance, as well as how these relationships change over time. Measurements were conducted with validated instruments across five time points during two school years with fourth and fifth grade students across ten schools (n = 636, 48% = female). This study was developed to address a need for examining how attitudes and perceived competence change over time. Descriptive statistics and latent growth models were run with the variables of interest to investigate four research …

Statement Of The Aspher Task Force On War And Public Health On The Conflict In Israel/Palestine, Oliver Razum, Paul Barach, Tomasz Bochenek, Colette Cunningham, Nadav Davidovitch, Polychronis Kostoulas, Jutta Lindert, Henrique Lopes, Vladimir Prikazsky, John Reid, Mirjana Kujundžić Tiljak, John Middleton

College of Population Health Faculty Papers

No abstract provided.

Chronic Intractable Migraine: A Case Study, Natalie Tate, Luis Alvarez, Cassidy Byers, Davis Elm, Louis Michelon, Tallon Muhlestein, Layla Risdon, Garret Vincent, Christina A. Small, David W. Sant, Kyle B. Bills, Kurt M. Alexander

Annual Research Symposium

No abstract provided.

Revolutionizing Denture Excellence: An Invigorating In-Vitro Exploration Of Organic Products In Prosthetic Rehabilitation, Nighila Ravindran, Sneha Joseph, Aswani Surya K

Annual Research Symposium

The denture base comes into contact with diverse substances in the oral cavity, acting as a reservoir for microorganisms like corynebacterium, streptococcus, lactobacillus, and candida. This colonization elevates the risk of complications such as denture stomatitis and candidiasis. Commercial denture cleaners have explored the use of natural ingredients, less commonly employed but offering various advantages. These ingredients aim to mitigate the potential issues associated with microbial colonization on denture surfaces, contributing to improved oral hygiene for denture wearers. The exploration of natural elements reflects a nuanced approach to denture care, considering both efficacy and less conventional alternatives.

Investigating Racial And Ethnic Healthcare Disparities In Screenable Ob/Gyn-Related Cancers, Lara Laughrey

Annual Research Symposium

This is a scoping review of peer-reviewed literature addressing healthcare inequity based on race and ethnicity with a specific focus on Ob/Gyn-related management and treatment of screenable cancers.

Assessment Of Emotional Intelligence Among Students In Dental College, Gowri Nandana S Final Year Student, Sudeep C. B Professor And Head Of The Department Of Public Health Dentistry

Annual Research Symposium

Over an extended period, the examination of intelligence predominantly centered on the adaptive deployment of cognitive abilities. In more recent times, scholars such as Gardner (1983) and Sternberg (1988) have proposed comprehensive frameworks for comprehending intelligence. Pioneering the concept of "emotional intelligence," Salovey and Mayer (1990) posited that emotional intelligence encompasses three distinct categories of adaptive capabilities: the evaluation and expression of emotions, the regulation of emotions, and the utilization of emotions in problem-solving. The objective is to evaluate emotional intelligence among dental students across various educational institutions.

Quality Of Life In Orthodontics, Claudia Eisenhuth, Gabriel Eisenhuth, Connor Schwartz, Amir Mohajeri, Man Hung, Tiffany Nelson, Ryann Glenn

Annual Research Symposium

Orthodontic treatment goes beyond mere cosmetic enhancement; it significantly impacts various aspects of an individual's quality of life. Beyond the physical benefits of improved oral function and prevention of dental issues, orthodontics also yields profound psychological benefits. Aligned teeth enhance self-confidence, reduce social anxiety, and contribute to better relationships and professional opportunities. Moreover, addressing dental concerns through orthodontic treatment reduces psychological distress and promotes overall happiness and satisfaction. Real-life case studies vividly illustrate the transformative effects of orthodontic interventions, emphasizing the importance of considering quality of life outcomes in dental care.

Immunogenicity Phase Ii Study Evaluating Booster Capacity Of Nonadjuvanted Aks-452 Sars-Cov-2 Rbd Fc Vaccine, David G Alleva, Eline A Feitsma, Yester F Janssen, Hendrikus H Boersma, Thomas M Lancaster, Thillainaygam Sathiyaseelan, Sylaja Murikipudi, Andrea R Delpero, Melanie M Scully, Ramya Ragupathy, Sravya Kotha, Jeffrey R Haworth, Nishit J Shah, Vidhya Rao, Shashikant Nagre, Shannon E Ronca, Freedom M Green, Stephen A Shaw, Ari Aminetzah, Schelto Kruijff, Maarten Brom, Gooitzen M Van Dam, Todd C Zion

Faculty, Staff and Students Publications

AKS-452, a subunit vaccine comprising an Fc fusion of the ancestral wild-type (WT) SARS-CoV-2 virus spike protein receptor binding domain (SP/RBD), was evaluated without adjuvant in a single cohort, non-randomized, open-labelled phase II study (NCT05124483) at a single site in The Netherlands for safety and immunogenicity. A single 90 µg subcutaneous booster dose of AKS-452 was administered to 71 adults previously primed with a registered mRNA- or adenovirus-based vaccine and evaluated for 273 days. All AEs were mild and no SAEs were attributable to AKS-452. While all subjects showed pre-existing SP/RBD binding and ACE2-inhibitory IgG titers, 60-68% responded to AKS-452 …

Exploring The Interconnected Role Of The Oral Microbiome And Periodontal Disease In The Development And Progression Of Oral Squamous Cell Carcinoma, Malak Al-Regib, Claudia M. Tellez Freitas

Annual Research Symposium

This comprehensive review explores the complex linkage among the oral microbiome, periodontal disease, and the onset and progression of oral squamous cell carcinoma (OSCC).

Non-Hodgkin's Lymphoma Of The Oral Cavity - A Rare Entity, Anita J. Florence Dr, Karpagaselvi Sanjai Prof & Dr

Annual Research Symposium

Non-Hodgkin’s lymphoma (NHL) is a subtype of lymphoma with two-thirds of the cases presenting as lymph node enlargement. The remaining one third of NHL cases has been reported in the extra nodal sites, including the gastro-intestinal tract, Waldeyer’s ring, bone, skin and brain. Intraoral NHL is uncommon and may affect either the jaw bones or occur within the soft tissues of the oral cavity. Here we report an unusual case of non-Hodgkin’s lymphoma in a 54-year-old male patient who presented with a growth from the right lower molar extraction socket with pus discharge.

Ocular Syphilis: A Case Report And Public Health Discussion, Andrew L. Fine, Hope V. Daskalakis, Rutwik Pradeep Sharma M.D., Mirna Ogeilat M.D.

Advances in Clinical Medical Research and Healthcare Delivery

Ocular Syphilis describes a localized manifestation of a systemic treponema pallidum infection. It most commonly presents with decreased visual acuity due to uveitis and can occur at any time throughout the disease course. This report describes a case of undiagnosed syphilis that was serendipitously diagnosed with blood product screening. This case highlights the need for better public education and outreach pertaining to sexually transmitted infections. This report will detail this patient's clinical course and discuss how healthcare providers can aid in early disease detection to improve both patient outcomes and overall public health.