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Short Relative Leg Length Is Associated With Overweight And Obesity In Mexican Immigrant Women, Mireya Vilar-Compte, James Macinko, Beth C. Weitzman, Carlos M. Avendaño-Villela

Department of Public Health Scholarship and Creative Works

Background: Prior research suggests that undernutrition and enteric infections predispose children to stunted growth. Undernutrition and infections have been associated with limited access to healthy diets, lack of sanitation, and access barriers to healthcare - all associated with human rights. Stunting has also been documented to be a major determinant of subsequent obesity and non-communicable diseases. Short leg length relative to stature during adulthood seems to be a good proxy indicator tracking such barriers, and has been reported to be associated with adverse health effects during adulthood. Our objective was to examine the association between relative leg length (as measured …

The Tampa Gym Study: An Ethnographic Exploration Of Gyms, Female Gym-Goers And The Quest For Fitness In Tampa, Fl, Danielle Reneé Rosen

USF Tampa Graduate Theses and Dissertations

The Tampa Gym Study was an ethnographic examination of veteran women exercisers, their workout routines, and their attitudes towards the workouts that they undertake in two Tampa area gyms. The study’s principle objective was to study “fitness culture” in these facilities and the manner in which that culture is embodied in the language women use to describe themselves and their exercise behaviors.

The obesity crisis in the United States has been significantly responsible for an increase in membership in gyms and fitness facilities nationwide. The “culture of fitness” as it is embodied in these facilities has impacted women and their …

Twenty-Three Unsolved Problems In Hydrology (Uph) -- A Community Perspective, Günter Blöschl, Marc F.P. Bierkens, Antonio Chambel, Christophe Cudennec, Georgia Destouni, Aldo Fiori, James W. Kirchner, Jeffrey J. Mcdonnell, Hubert H.G. Savenjie, Murugesu Sivapalan, Christine Stumpp, Elena Toth, Elena Volpi, Gemma Carr, Claire Lupton, Jose Salinas, Borbala Szeles, Alberto Viglione, Hafzullah Aksoy, Scott T. Allen, Anam Amin, Vazken Andreassian, Berit Arheimer, Santosh K. Aryal, Victor Baker, Earl Bardsley, Marlies H. Barendrecht, Alena Bartosova, Okke Batelaan, Wouter R. Berghuijs, Keith Beven

Geoscience Faculty Research

This paper is the outcome of a community initiative to identify major unsolved scientific problems in hydrology motivated by a need for stronger harmonisation of research efforts. The procedure involved a public consultation through online media, followed by two workshops through which a large number of potential science questions were collated, prioritised, and synthesised. In spite of the diversity of the participants (230 scientists in total), the process revealed much about community priorities and the state of our science: a preference for continuity in research questions rather than radical departures or redirections from past and current work. Questions remain focused …

Aligning Ocean Plastic Pollution And Human Health A Co-Benefits Approach, Karyn Morrissey Dr

Journal of Ocean and Coastal Economics

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The environmental literature has begun to consider the impact of environmental problems on human health. This realization serves both as a means to provide scientific evidence to consider the environment and public health jointly. This approach also increases recognition of the environment where stakeholders have not understood the links between environmental and human health. The oceans and seas play an important role in human health, through the provision and quality of the air that we breathe, the food we eat, the water we drink, while offering economic and recreational opportunities which enhance public health. However, the links between human …

Acceptability Of Active Case Finding With A Seed-And-Recruit Model To Improve Tuberculosis Case Detection And Linkage To Treatment In Cambodia: A Qualitative Study, Sovannary Tuot, Alvin K. J. Teo, Danielle Cazabon, Say Sok, Mengieng Ung, Sangky Ly, Sok Chamreun Choub, Siyan Yi

Background

With support of the national tuberculosis (TB) program, KHANA (a local non-governmental organization in Cambodia) has implemented an innovative approach using a seed-and-recruit model to actively find TB cases in the community. The model engaged community members including TB survivors as seed and newly diagnosed people with TB as recruiters to recruit presumptive TB cases in their social network in a snowball approach for screening and linkage to treatment. This study aimed to explore the acceptability of the active case finding with the seed-and-recruit model in detecting new TB cases and determine the characteristics of successful seeds.

Methods

This …

Association Between Snps In The Vitamin D Binding Protein, Vitamin D Status, And Aggressive Prostate Cancer By Race, Diana Diaz

Theses and Dissertations

Prostate cancer incidence and mortality have been decreasing in recent years, but it remains the most commonly diagnosed cancer among men. Racial disparities exist in prostate cancer with African Americans (AAs) having notably higher rates of incidence and mortality, lower survival rates, and are more likely to be diagnosed with a highergrade cancer compared to European Americans (EAs). Genome-wide association studies have revealed several single nucleotide polymorphisms (SNPs) within the vitamin Drelated GC gene that may be associated with prostate cancer aggressiveness. In addition to SNPs, previous research has suggested that low levels of 25-hydroxyvitamin D (25(OH)D) may be related …

Pre-Exposure Prophylaxis (Prep) For Hiv Prevention: A Mixed-Methods Study Of Sexual Risks And Knowledge, Perceptions, And Willingness Of Prep Use Among African American Women In The South, Jamie Troutman

Theses and Dissertations

There are approximately 1.1 million people living with HIV in United States, with nearly 40,000 new diagnoses annually. Significant regional and racial disparities are associated with HIV diagnoses — with the South experiencing the greatest burden of HIV and African American women accounting for 60% of new diagnoses among women. Pre-exposure prophylaxis (PrEP) has been designated as an effective tool to prevent HIV transmission among individuals who may be at risk of HIV infection. Earlier PrEP research has focused mainly on at-risk groups such as men who have sex with men (MSM). Previous PrEP research involving African American women included …

Experience Of Persistent Pain Among Military Service Members Participating In An Interdisciplinary Intensive Outpatient Program, Barbara Katarzyna Bujak

Theses and Dissertations

Persistent pain is one of today’s most complex issues in healthcare. In the U.S. military, persistent pain affects close to half of the service members who have deployed overseas and up to 73.2% of service members and veterans experiencing persistent pain. Interdisciplinary pain management, considered one of the most effective ways to manage persistent pain, utilizes the biopsychosocial model that illustrates the dynamic interaction between the physiological, psychological and social factors involved in the experience of persistent pain. Effective interdisciplinary programs address all components of the model and result in better coping skills to self-manage persistent pain, decreased fear of …

Evaluating Impacts Of A Multilevel Resilience-Based Psychosocial Intervention On Mental Health Of Children Affected By Parental Hiv In China, Yanping Jiang

Theses and Dissertations

Background: Children affected by parental HIV are commonly exposed to multiple risk factors, including parental illness and death, other traumatic life events, HIV stigma, and poverty, all of which in turn put them at elevated risk of experiencing poor mental health outcomes. Previous research has suggested the promise of psychosocial interventions in improving mental health for children affected by parental HIV through an integrated and multilevel resilience-based approach. However, there are few multilevel resilience-based interventions for this group, and the efficacy of such interventions on mental health outcomes has not been fully examined. Furthermore, very few studies have examined whether …

Disparities In Non-Small Cell Lung Cancer In The United States: An Examination Of Treatment, Survival, And Access To Care, Cassie Lewis Odahowski

Theses and Dissertations

Lung cancer is the leading cause of cancer-related deaths in the United States with a 5-year survival rate of only 18%. Differences in access to care and treatment utilization may play a role in observed survival disparities among rural patient populations. This dissertation aimed to examine rural disparities in all-cause and lung-cancer specific survival, time to treatment initiation, and utilization of surgical treatment among non-small cell lung cancer cases.

We utilized comprehensive cancer registry data from the Surveillance, Epidemiology, and End Results program linked with Medicare billing claims (SEER-Medicare) for non-small cell lung cancer (NSCLC) patients diagnosed between 2003-2011. We …

The Association Of Cardiorespiratory Fitness With Advancing Age Among Those With And Without Type Ii Diabetes, Amber Kathlyn Watson

Theses and Dissertations

OBJECTIVE: This study examined the relationship between cardiorespiratory fitness (CRF) and age to determine if the decrease in CRF associated with advancing age is greater among those with type 2 diabetes mellitus (T2DM) as compared to those without T2DM. This study also assessed if differences in CRF between persons with T2DM and those without are consistent across CRF percentiles.

METHODS: Data from the Aerobics Center Longitudinal Study (ACLS, Dallas, Texas, 1970-2006) were utilized in the current study. CRF was measured by maximal treadmill exercise testing using the Balke protocol and T2DM status was determined by self-report of previous diagnosis by …

Disparities In Colorectal Cancer: Measuring Spatial Accessibility, Screening, And Surveillance Outcomes In South Carolina, Michele J. Josey

Theses and Dissertations

The purpose of this dissertation project is to add to the growing literature about the multi-faceted aspects of colorectal cancer (CRC) prevention and related disparities. We focused on the spatial distribution of facilities performing screening services to identify areas that underutilize colonoscopy screening. Next, we examined how the food and physical activity environment affects precursors of CRC by considering plausible pathways. Finally, we explored if access to health insurance reduced the racial disparity of receiving a timely surveillance colonoscopy after a CRC diagnosis.

We utilized the SC Ambulatory Surgery Discharge Database, an all-payer, population-based outpatient dataset with colonoscopy records from …

Risk And Resilience Pertaining To Mental Health Of Youth Attending A College In Kathmandu Who Were Exposed To The 2015 Earthquakes During Their Adolescence: A Mixed Method Study, Vinita Sharma

USF Tampa Graduate Theses and Dissertations

Background: Adverse mental health outcomes have been previously reported among survivors of natural disasters. Available studies mostly focus on risk factors and not resilience. In 2015, a series of earthquakes caused massive loss of lives and livelihood in Nepal. Epidemiological data pertaining to youth mental health in Nepal is limited. Information about the post-earthquake mental health of youth who were exposed to earthquakes during their adolescence in Nepal is scarce.

Purpose: The purpose of this study was to address risk and resilience factors related to mental health among college-attending Nepali youth (18-20 years) exposed to the 2015 earthquake during their …

Death By Contamination, Syeda Sana Batool

MSJ Capstone Projects

This research was conducted by Centre for Excellence in Journalism, IBA, Karachi during 2019 as a capstone project for Master of Science in Journalism. The data and information regarding water contamination was obtained and compiled through a thorough reporting, researched articles and documents provided by concerned organization.

The water which is used for the drinking purpose in Karachi is the most polluted and contaminated one as compare to the other cities of Pakistan. The reason behind this water contamination is the industries disposition of waste, which has ruined the environment by polluting the water bodies with its toxic effluent.

The …

The Suffering Of Schizophrenia: Stigma, Enigma And The Search For A Cure, Fatima Sheikh

MSJ Capstone Projects

Patients suffering from Schizophrenia, a severe mental illness, firmly believe in their delusions due to a loss of connection with reality and creation of an imaginary world. Generally, diagnosis and treatment of the mental disorder have been ignored due to cultural and social setup in Karachi. Schizophrenia cannot be cured but manageable with lifetime medicines and rehabilitation after each lapse. The purpose of my investigative piece is to highlight the stigma attached to Schizophrenia along with a search for its treatment.

Karakteristik Pasien Tuberkulosis Lost To Follow Up Dari Empat Rs Di Kota Bandung, Azizah Muthiah, Noormarina Indraswari, Budi Sujatmiko

Jurnal Epidemiologi Kesehatan Indonesia

Jumlah kasus tuberkulosis (TB) yang tidak terlaporkan dan tidak terdeteksi di Indonesia sebelum pelaksanaan sistem pengawasan TB nasional pada tahun 2017 mencapai 47% dari total kasus, termasuk di dalamnya kasus TBlost to follow up atau hilang dari pengamatan. Pasien yang termasuk dalam kelompok ini akan meningkatkan risiko perburukan klinis, kambuh, gagal pengobatan, dan menjadi resistan terhadap obat, selain itu mereka juga akan mejadi sumber penularan di masyarakat. Tujuan penelitian ini yaitu untuk mengetahui karakteristik pasien rawat jalan TB yang hilang dari pengamatan dari empat rumah sakit terpilih di Kota Bandung. Penelitian ini menggunakan studi deskriptif dengan rancangan potong lintang. Sampel …

Determinan Yang Meningkatkan Risiko Terinfeksi Hiv Pada Wargabinaan Lembaga Pemasyarakatan Dan Rumah Tahanan Di Indonesia: Studi Tinjauan Pustaka 2007-2017, Mondastri Korib Sudaryo

Jurnal Epidemiologi Kesehatan Indonesia

Wargabinaan pemasyarakatan (WBP) diduga berisiko terinfeksi HIV selama tinggal di lembaga pemasyarakatan (lapas) dan rumah tahanan (rutan) akibat menyuntik narkotika dan perilaku berisiko lainnya. Studi ini bertujuan mengetahui determinan yang meningkatkan faktor risiko terinfeksi HIV di kalangan WBP di lapas/rutan di Indonesia. Rancangan studi adalah tinjauan pustaka sistematik (systematic literature review) yang merangkum dan membandingkan hasil studi dari 12 artikel yang diterbitkan sejak 2007 2017 di jurnal nasional/internasional berbahasa Inggris/Indonesia mengenai karakteristik dan determinan infeksi HIV pada populasi WBP yang tinggal di lapas/rutan di Indonesia. Karakteristik demografis WBP: umumnya laki laki; usia rata-rata 30 tahun (rentang: 21-51 tahun); sebagian besar <=SMU; setengahnya menikah. Prevalensi HIV di kalangan WBP di beberapa lapas: 10%-56%. Tiga survei nasional tahun 2011, 2013, 2015 menunjukkanprevalence rate antara 1,2% – 3%. Proporsi perilaku berisiko: menyuntik narkotika (antara 5% - 66%), berbagi jarum suntik (28%-47%), kontak seksual tidak aman dengan sesama WBP (2%-13%), atau dengan WPS (96%), pakai tattoo (2%-56%), atau tindik (5%-13%), minum alkohol (47%). Dari 3 survey yang sama tingkat prevalensi Sifilis antara 2,1%– 5%. Determinan/faktor risiko terinfeksi HIV: menggunakan narkotika suntik (OR antara 11,4 - 104,8), pakai tatoo (OR: 1,7 -2,4), pakai tindik (OR = 4,4), seks tidak aman (OR=1,9), terinfeksi Sifilis (OR=4,2). Faktor-faktor penting yang meningkatkan risiko terinfeksi HIV di kalangan WBP di lapas/rutan adalah penggunaan narkotika suntik, berbagi jarum suntik tidak steril, kontak seksual dengan sesama WBP &/ WPS, terinfeksi Sifilis dan memakai tato/tindik.

Gender And Hypertantion (Data Analysis Of The Indonesia Basic Health Research 2007), Krisnawati Bantas, Dwi Gayatri

Jurnal Epidemiologi Kesehatan Indonesia

The objective of this study was to examine whether there was a gender difference in the occurrence of hypertension in Indonesian people, after controlling for individual and environment factors. Data were ob tained from the Indonesia Basic Health Research 2007 and a cross sectional design was used. Samples consisted of 13.262 men and women age 15 years or more. A multilevel logistic regression was used to ana lyze the data. There was a statistically significant association between gender and hypertension. Women were less likely to have hypertension than men (OR 0.86 P value < 0.0033). There was an interaction between variable of gender and variable of age. It suggested that the probability of having hypertension in women and men was varied by the strata of age. In the strata of age more than 60 years, women were more likely to have hypertension than men (OR 1.25, P value 0.0065); in strata of age 30-59 years, there was no difference of having hypertension between women and men (P value > 0.05); in strata of age <30 years, women were less likely to have hypertension than men (OR 0.67 Pvalue 0.0000). Among women, there was an increased of having hypertension with age. Age of e” 60 years was the highest risk of having hypertension. Among men, there was an increased of having hypertension with age, but at in the age of e” 60 years the increased risk of having hypertension was not as high as in women.

Prevalence And Correlates Of Diagnosed And Undiagnosed Hypertension In The Indigenous Kuna Population Of Panamá, Daniel R. Hanna, Rebekah J. Walker, Brittany L. Smalls, Jennifer A. Campbell, Aprill Z. Dawson, Leonard E. Egede

Center for Health Services Research Faculty Publications

Background: To determine the prevalence of hypertension and investigate sociodemographic correlates in an indigenous Kuna community living on the San Blas islands of Panama.

Methods: Data was collected from adults using a paper-based survey using a cross sectional study design. Blood pressure was measured, and hypertension defined at two cut-points: 130/80 mmHg and 140/90 mmHg. Individuals with undiagnosed hypertension had a blood pressure measurement that indicated hypertension, however, the individual had not been told by a doctor they had hypertension. Whereas individuals with diagnosed hypertension had been told by a healthcare provider that they had hypertension. Univariate tests compared diagnosed …

Understanding The Implementation Of Integrated Care For People Living With Hiv, Vickie A. Lynn

USF Tampa Graduate Theses and Dissertations

Introduction: The integration of physical and behavioral health services is an innovative method of delivering health care services for persons dual or triply diagnosed with HIV, mental health and/or substance use disorders. Reducing the fragmented delivery of health services by integrating services into one setting is essential to providing holistic patient-centered care and address the complex health needs of this population. Although research shows integrated care improves health outcomes, little is known about the implementation of integrated care in real-world settings because the perspectives and experiences of those delivering and receiving integrated health and social services are underrepresented in the …

Risk Of Cancer Death Among White, Black, And Hispanic Populations In South Florida, Paulo S. Pinheiro, Karen E. Callahan, Tulay Koru-Sengul, Justine Ransdell, Layla Bouzoubaa, Clyde P. Brown, Erin Kobetz

Environmental & Global Health Faculty Research

Background: The cancer burden in South Florida, with a population of more than 6 million with a heavily Hispanic and large Afro-Caribbean population, has not been quantified. Methods: We analyzed 2012–2016 cancer mortality data from South Florida for white, Hispanic, and black populations with disaggregation for Cuban, Puerto Rican, South American, African American, and Afro-Caribbean groups. We calculated cancer site-specific and all-sites combined age-adjusted mortality rates, and we used negative binomial regression to determine mortality rate ratios to compare South Florida’s cancer mortality rates with those of the rest of the nation. Results: We analyzed 53,837 cancer deaths. Per 100,000 …

A Systematic Review And Analysis Of Racial Differences In Treatment For Depression, Elli D. R. Parisi

DePaul Discoveries

Mental health affects a large proportion of the population across the world. Though many mental health studies exist, they are inconsistent in methodology, conceptualization of terms, and populations studied; as a result, many studies are incomparable with each other. Further, there is arguably too few studies that focus on marginalized or underrepresented populations. The current study aims to address some of this gap in knowledge. The differences in the way depression is diagnosed and treated in various racial and ethnic groups were identified, and the findings of previous studies were analyzed to help improve the way mental health, and specifically …

The Cost Of Improving Nutritional Outcomes Through Food‐Assisted Maternal And Child Health And Nutrition Programmes In Burundi And Guatemala, Jessica Heckert, Jef L. Leroy, Deanna K. Olney, Susan Richter, Elyse Iruhiriye, Marie T. Ruel

Faculty Publications

Evidence on the cost‐effectiveness of multisectoral maternal and child health and nutrition programmes is scarce. We conducted a prospective costing study of two food‐assisted maternal and child health and nutrition programmes targeted to pregnant women and children during the first 1,000 days (pregnancy to 2 years). Each was paired with a cluster‐randomized controlled trial to evaluate impact and compare the optimal quantity and composition of food rations (Guatemala, five treatment arms) and their optimal timing and duration (Burundi, three treatment arms). We calculated the total and per beneficiary cost, conducted cost consequence analyses, and estimated the cost savings from extending …

Evolutionary Dynamics Of Influenza Type B In The Presence Of Vaccination: An Ecological Study, Lindsey J. Fiedler

USF Tampa Graduate Theses and Dissertations

Understanding the evolutionary dynamics of influenza type B in human hosts is a public health concern as we strive to minimize the disease burden in seasonal epidemics. Vaccination is considered the best defense against contracting influenza, and everyone over the age of 6 months is advised to get vaccinated before each season. The effect that vaccine-acquired immunity has on the evolution of influenza B remains unclear. In the U.S., vaccine-uptake is irregular across the states, and the differing coverages present an opportunity to study how vaccination influences viral evolution. This thesis analyzes the evolutionary patterns of influenza B in the …

Exploring Young Women’S Choice To Initiate Use Of Long-Acting Reversible Contraception: A Mixed Methods Approach, Helen Mahony

USF Tampa Graduate Theses and Dissertations

Background: The United States has the highest rate of unintended pregnancy compared to any other developed country. Unintended pregnancy is associated with negative health outcomes for both parents and children. It is estimated that government expenditures for unintended pregnancy total $21 billion each year. Women ages 18-25 years old have the highest rate of unintended pregnancy. This age group is categorized as emerging adulthood, and this is a unique developmental period in a person’s life. Given the high rate of unintended pregnancies and the associated negative outcomes, increasing the use of more reliable methods of birth control is a public …

Neighborhood-Level Predictors Of Obesity Among African American Children In California, Uche Onyeka

Journal of Social, Behavioral, and Health Sciences

The increased prevalence of childhood obesity is a major public health concern nationally and globally. Childhood obesity is primarily caused by the imbalance between caloric intake and caloric expenditure; however, its increase over the past decades may be due to environmental and behavioral factors. The purpose of the current study was to examine if any relationships existed between childhood obesity, level of physical activity, and neighborhood-level risk factors. This study used the California Health Interview Survey 2009–2014 data sets for African American children aged 5–11 years (n = 1,049). The dependent variable was body mass index (BMI) while the …

Structural Racism And Severe Maternal Morbidity In New York State, Sze Yan Liu, Christina Fiorentini, Zinzi Bailey, Mary Huynh, Katherine Mcveigh, Deborah Kaplan

Department of Public Health Scholarship and Creative Works

ABSTRACT

Objective: We examined the association between county-level structural racism indicators and the odds of severe maternal morbidity (SMM) in New York State.

Design: We merged individual-level hospitalization data from the New York State Department of Health Statewide Planning and Research Cooperative System (SPARCS) with county-level data from the American Community Survey and the Vera Institute of Justice from 2011 to 2013 (n = 244 854). Structural racism in each county included in our sample was constructed as the racial inequity (ratio of black to white population) in female educational attainment, female employment, and incarceration.ReSulT S: Multilevel logistic regression analysis …

A Rapid Viability And Drug‑Susceptibility Assay Utilizing Mycobacteriophage As An Indicator Of Drug Susceptibilities Of Anti‑Tb Drugs Against Mycobacterium Smegmatis Mc2 155, Gillian Catherine Crowley, Jim O'Mahony, Aidan Coffey, Riona G. Sayers, Paul D. Cotter

Department of Biological Sciences Publications

Background: A rapid in-house TM4 mycobacteriophage-based assay, to identify multidrug resistance against various anti-tuberculosis drugs, using the fast-growing Mycobacterium smegmatis mc² 155 in a microtiter plate format was evaluated, based on phage viability assays. Methods: A variety of parameters were optimized before the study including the minimum incubation time for the drugs, phage and M. smegmatis mc² 155 to be in contact. An increase in phage numbers over 2 h was indicative that M. smegmatis mc² 155 is resistant to the drugs under investigation, however when phage numbers remained static, M. smegmatis mc² 155 found to …

An Integrative Cross-Omics Analysis Of Dna Methylation Sites Of Glucose And Insulin Homeostasis, Jun Liu, Elena Carnero-Montoro, Jenny Van Dongen, Samantha Lent, Ivana Nedeljkovic, Symen Ligthart, Pei-Chien Tsai, Tiphaine C. Martin, Pooja R. Mandaviya, Rick Jansen, Marjolein J. Peters, Liesbeth Duijts, Vincent W. V. Jaddoe, Henning Tiemeier, Janine F. Felix, Gonneke Willemsen, Eco J. C. De Geus, Audrey Y. Chu, Daniel Levy, Shih-Jen Hwang, Jan Bressler, Rahul Gondalia, Elias L. Salfati, Christian Herder, Bertha A. Hidalgo, Toshiko Tanaka, Ann Zenobia Moore, Rozenn N. Lemaitre, Min A. Jhun, Jennifer A. Smith, Donna K. Arnett

Epidemiology and Environmental Health Faculty Publications

Despite existing reports on differential DNA methylation in type 2 diabetes (T2D) and obesity, our understanding of its functional relevance remains limited. Here we show the effect of differential methylation in the early phases of T2D pathology by a blood-based epigenome-wide association study of 4808 non-diabetic Europeans in the discovery phase and 11,750 individuals in the replication. We identify CpGs in LETM1, RBM20, IRS2, MAN2A2 and the 1q25.3 region associated with fasting insulin, and in FCRL6, SLAMF1, APOBEC3H and the 15q26.1 region with fasting glucose. In silico cross-omics analyses highlight the role of differential methylation …

Collaborative Molecular Epidemiology Study Of Metabolic Dysregulation, Dna Methylation, And Breast Cancer Risk Among Nigerian Women: Mend Study Objectives And Design, Tomi Akinyemiju, Omolola Salako, Adetola Daramola, Olusegun Alatise, Adewale Adeniyi, Gabriel Ogun, Omobolaji Ayandipo, Thomas Olajide, Olalekan Olasehinde, Olukayode Arowolo, Adewale Adisa, Oludolapo Afuwape, Aralola Olusanya, Aderemi Adegoke, Akinlolu Ojo, Trygve Tollefsbol, Donna K. Arnett

Epidemiology and Environmental Health Faculty Publications

PURPOSE To elucidate the role of metabolic dysregulation and associated DNA methylation changes on breast cancer risk and aggressive subtypes among Nigerian women. We describe the design and methods of a collaborative molecular epidemiology study of breast cancer in Nigerian hospitals.

METHODS The Mechanisms for Novel and Established Risk Factors for Breast Cancer in Women of Nigerian Descent (MEND) study was designed as a matched case-control study of 350 patients, age 18 to 75 years, with newly diagnosed, treatment-naïve breast cancer and 350 age-matched healthy controls from surrounding geographic areas. Patients with breast cancer seen for initial diagnosis at four …