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Qualitative Study Of Factors Contributing To Fertility Service Use Among Cancer Survivors Of Reproductive Age In The Us, Angela Rodgers Moore Jan 2021

Qualitative Study Of Factors Contributing To Fertility Service Use Among Cancer Survivors Of Reproductive Age In The Us, Angela Rodgers Moore

College of Graduate Studies: Theses & Dissertations

Cancer remains the second leading cause of death in the United States; however, there has been a decline in incidence and mortality due to advances in screening and treatment. Currently 16.9 million survivors are thriving within the United States, and the population of cancer survivors has been projected to grow to 22.2 million by 2030. Although cancer survivors report an increased surge of vitality and vigor, they often face physical, mental, psychosocial, or financial challenges that threaten their quality of life. A late treatment effect of particular concern for cancer survivors of reproductive age that has both physical and psychosocial …


Understanding And Promoting Racial Diversity In Healthcare Settings To Address Disparities In Pandemic Crisis Management, Azza Sarfraz, Zouina Sarfraz, Alanna Barrios, Kuchalambal Agadi, Sindhu Thevuthasan, Krunal Pandav, Manish Kc, Muzna Sarfraz, Pedram Rad, George Michel Jan 2021

Understanding And Promoting Racial Diversity In Healthcare Settings To Address Disparities In Pandemic Crisis Management, Azza Sarfraz, Zouina Sarfraz, Alanna Barrios, Kuchalambal Agadi, Sindhu Thevuthasan, Krunal Pandav, Manish Kc, Muzna Sarfraz, Pedram Rad, George Michel

Department of Paediatrics and Child Health

Background: Health disparities have become apparent since the beginning of the COVID-19 pandemic. When observing racial discrimination in healthcare, self-reported incidences, and perceptions among minority groups in the United States suggest that, the most socioeconomically underrepresented groups will suffer disproportionately in COVID-19 due to synergistic mechanisms. This study reports racially-stratified data regarding the experiences and impacts of different groups availing the healthcare system to identify disparities in outcomes of minority and majority groups in the United States.
Methods: Studies were identified utilizing PubMed, Embase, CINAHL Plus, and PsycINFO search engines without date and language restrictions. The following keywords were used: …


Underreporting Of Intimate Partner Violence Against Women: An Important Public Mental Health Implication, Sandhya Lohani, Sha-Hanna Saffold, Tanya Jules, Brenda Blackwell, Suzanne Shurling, Tilicia Mayo-Gamble Jan 2021

Underreporting Of Intimate Partner Violence Against Women: An Important Public Mental Health Implication, Sandhya Lohani, Sha-Hanna Saffold, Tanya Jules, Brenda Blackwell, Suzanne Shurling, Tilicia Mayo-Gamble

Eagles Talking About the Public’s Health

No abstract provided.


The Interplay Of Policy, Behavior, And Socioeconomic Conditions In Early Covid-19 Epidemiology In Georgia, Mallory J. Harris, Ella Tessier-Lavigne, Erin Mordecai Jan 2021

The Interplay Of Policy, Behavior, And Socioeconomic Conditions In Early Covid-19 Epidemiology In Georgia, Mallory J. Harris, Ella Tessier-Lavigne, Erin Mordecai

Journal of the Georgia Public Health Association

Publishing Note: This article has been published in its peer-reviewed and accepted form as a post-print version. The fully formatted version of the article will be published on this record when it is available.


ABSTRACT

Background: As COVID-19 began to spread worldwide, local socioeconomic and health factors and nonpharmaceutical interventions may have affected epidemiological outcomes. To investigate the associations between public health orders, behavior, and population factors, and early epidemic dynamics, we investigated variation among counties in the U.S. state of Georgia. There, a large early outbreak occurred in March 2020 with varying levels of local nonpharmaceutical interventions prior to …


Parental School Involvement On Physical Activity And Screen Time Among Middle And High School Students, Joseph Greer, Kiran Thapa, Jessica Mcnulty, Janani R. Thapa Jan 2021

Parental School Involvement On Physical Activity And Screen Time Among Middle And High School Students, Joseph Greer, Kiran Thapa, Jessica Mcnulty, Janani R. Thapa

Journal of the Georgia Public Health Association

Background: High levels of sedentary activity and low levels of physical activity have led to an increase in childhood obesity. A reduction of sedentary behavior and the promotion of an active lifestyle positively impacts weight status of children. A child may modify their behavior through direct interventions from their parents, such as enforcement of rules or guided activities, or through broad interventions, by expressing their values and modeling behavior. Current research does not establish if broad or specific parental involvement has a greater effect on healthy behavior. Our group sought to support existing evidence that parental involvement directly impacts behavior …


Racial Disparities In Hypertension Self-Awareness And Hospitalizations For Hypertension-Related Illnesses Among Adult Arkansans, Chimfumnanya Nwanze-Smith Jan 2021

Racial Disparities In Hypertension Self-Awareness And Hospitalizations For Hypertension-Related Illnesses Among Adult Arkansans, Chimfumnanya Nwanze-Smith

Walden Dissertations and Doctoral Studies

Black individuals in the United States are twice as likely as White individuals to die of cardiovascular diseases. Between 2010 and 2016 in Arkansas (AR), hypertension (HTN) and HTN-related diseases had an age-adjusted death rate of 230.4 deaths per 100,000 population compared to 173.6 deaths per 100,000 population for Whites. The purpose of this quantitative, cross-sectional study was to explore the potential association between HTN self-awareness and emergency department (ED) visits and hospitalization rates for HTN and HTN-related illnesses between Black and White individuals in AR. The socioecological framework was used to explore sociodemographic (SDF) and socioeconomic (SES) factors as …


Reproductive Health Factors And Maternal Mortality Of Internally Displaced Women In Nigeria, Fatima Mahmood Jibirilla Jan 2021

Reproductive Health Factors And Maternal Mortality Of Internally Displaced Women In Nigeria, Fatima Mahmood Jibirilla

Walden Dissertations and Doctoral Studies

Approximately 529,000 women die from pregnancy-related causes every year, with 99% of these maternal deaths occurring in developing countries. Each year, about 59,000 maternal deaths occur in Nigeria, with a mortality rate of 576 deaths per 100,000 births. Women constitute about half of the 33.2 million internally displaced persons (IDPs) worldwide. The purpose of this retrospective cross-sectional study was to explore the association between the reproductive health factors and maternal mortality of internally displaced women in Borno state, Nigeria. McCarthy and Maine’s model for determinants of maternal mortality informed this study. A secondary dataset of 400 women (age 14-49 years) …


Effect Of Insecticide-Treated Nets On Anemia In Nigerian Children, Adamu Onu Jan 2021

Effect Of Insecticide-Treated Nets On Anemia In Nigerian Children, Adamu Onu

Walden Dissertations and Doctoral Studies

Childhood anemia is a significant public health problem in Nigeria and frequently coexists with malaria. The mortality associated with malaria increases when anemia is present. Insecticide-treated nets (ITNs) are a cheap and effective malaria preventive measure that can provide a protective barrier from insects. There are conflicting results from several studies on the effect of ITNs on anemia in children, with fewer studies on the effect of ITNs on anemia in Nigerian children. This study aimed to measure the effect of ITN use on anemia among children aged 6–59 months in Nigeria. The social ecological model was used as the …


Connectivity: Insights From The U.S. Long Term Ecological Research Network, David M. Iwaniec, Michael Gooseff, Katharine N. Suding, David Samuel Johnson, Daniel C. Reed, Debra P. C. Peters, Byron Adams, John E. Barrett, Brandon T. Bestelmeyer, Max C. N. Castorani, Elizabeth M. Cook, Melissa J. Davidson, Peter M. Groffman, Niall P. Hanan, Laura F. Huenneke, Pieter T. J. Johnson, Diane M. Mcknight, Robert J. Miller, Gregory S. Okin, Daniel L. Preston, Andrew Rassweiler, Chris Ray, Osvaldo E. Sala, Robert L. Schooley, Timothy Seastedt, Marko J. Spasojevic, Enrique R. Vivoni Jan 2021

Connectivity: Insights From The U.S. Long Term Ecological Research Network, David M. Iwaniec, Michael Gooseff, Katharine N. Suding, David Samuel Johnson, Daniel C. Reed, Debra P. C. Peters, Byron Adams, John E. Barrett, Brandon T. Bestelmeyer, Max C. N. Castorani, Elizabeth M. Cook, Melissa J. Davidson, Peter M. Groffman, Niall P. Hanan, Laura F. Huenneke, Pieter T. J. Johnson, Diane M. Mcknight, Robert J. Miller, Gregory S. Okin, Daniel L. Preston, Andrew Rassweiler, Chris Ray, Osvaldo E. Sala, Robert L. Schooley, Timothy Seastedt, Marko J. Spasojevic, Enrique R. Vivoni

Advanced Science Research Center

Ecosystems across the United States are changing in complex and surprising ways. Ongoing demand for critical ecosystem services requires an understanding of the populations and communities in these ecosystems in the future. This paper represents a synthesis effort of the U.S. National Science Foundation-funded Long-Term Ecological Research (LTER) network addressing the core research area of “populations and communities.” The objective of this effort was to show the importance of long-term data collection and experiments for addressing the hardest questions in scientific ecology that have significant implications for environmental policy and management. Each LTER site developed at least one compelling case …


The Big Data Regulator, Rebooted: Why And How The Fda Can And Should Disclose Confidential Data On Prescription Drugs And Vaccines, Christopher J. Morten, Amy Kapczynski Jan 2021

The Big Data Regulator, Rebooted: Why And How The Fda Can And Should Disclose Confidential Data On Prescription Drugs And Vaccines, Christopher J. Morten, Amy Kapczynski

Faculty Scholarship

Medicines and vaccines are complex products, and it is often extraordinarily difficult to know whether they help or hurt. The Food and Drug Administration (FDA) holds an enormous reservoir of data that sheds light on that precise question, yet currently releases only a trickle to researchers, doctors, and patients. Recent examples show that data secrecy can be deadly, and existing laws such as the Freedom of Information Act (FOIA) cannot solve the problem. We present here a wealth of new evidence about the urgency of the problem and argue that the FDA must “reboot” its rules to proactively disclose all …


“It Didn’T Matter What The Bill Said...”: Influences On Abortion Policy Legislative Decision-Making In Georgia, Erica Barton, Subasri Narasimhan, Dabney P. Evans Jan 2021

“It Didn’T Matter What The Bill Said...”: Influences On Abortion Policy Legislative Decision-Making In Georgia, Erica Barton, Subasri Narasimhan, Dabney P. Evans

Journal of the Georgia Public Health Association

Background: In March 2019 the Georgia legislature passed HB 481 described as a “heartbeat bill”, prohibiting abortion at around six weeks gestation. Given the prevalence of anti-abortion legislation and the public health implications of abortion restrictions, we sought to understand how Georgia legislators made decisions on this early abortion ban legislation.

Methods: We conducted in-depth interviews with nine legislators from the Georgia House of Representatives who participated in the 2019 legislative session. In-depth interviews were conducted in-person and over the phone. Interview recordings were transcribed verbatim and inductive codes identified. Codes focused primarily on views of: abortion in general; specific …


How Did We Learn About Sex? —— Sex Education And Sexual Health In Chinese Youth, Yujuan Liu Jan 2021

How Did We Learn About Sex? —— Sex Education And Sexual Health In Chinese Youth, Yujuan Liu

Theses and Dissertations (Comprehensive)

Attitudes toward sexuality among Chinese youth have become more liberal in recent generations, but sex education remains controversial and limited. Due to the lack of awareness of sexual risks, many Chinese youth engage in unprotected sexual activities resulting in unintended pregnancy, abortions, and STIs. Therefore, understanding successful pathways and unique challenges are crucial to develop adequate sex education for youth’s sexual health in China. The current study used semi-structured in-depth interviews and investigated 28 Chinese youths’ experiences of sex education and sexual health. The results mapped out youth’s sex education experiences by age and sources and demonstrated the impacts of …


Covid-19: Race For Vaccine, L. Hayley Burgess, Jason J. Braithwaite, Emily Singleton, Aaron M. Young, Mandelin K. Cooper Dec 2020

Covid-19: Race For Vaccine, L. Hayley Burgess, Jason J. Braithwaite, Emily Singleton, Aaron M. Young, Mandelin K. Cooper

HCA Healthcare Journal of Medicine

The world is in the midst of a pandemic from COVID-19, a disease caused by the virus SARS-CoV-2. Despite broad mitigation efforts, new cases continue with 74 million cases and 1.6 million deaths worldwide. Regardless of previous research efforts, there is no commercially available vaccine for any coronavirus. Novel vaccine development has historically taken at least 10 years from discovery to availability with only a 6% market entry probability.

With the global impact, there is an urgency to expedite a vaccine to protect the population. The U.S. government launched Operation Warp Speed with the goal to produce and deliver 300 …


Cold Storage Work And Cold Protective Gloves – A Review, Daena Charles Dec 2020

Cold Storage Work And Cold Protective Gloves – A Review, Daena Charles

Theses

The rise of e-commerce and the increasing demand for online grocery shopping and delivery has prompted the growth of warehouse workers subjected to cold temperature working conditions. To ensure food safety and the preservation of inventory, majority of these e-grocery warehouses are cold storage with temperatures from 10°C to -23°C. Exposure to such cold working environments can have effects on the workers comfort, performance and health. As the demand for workers in cold temperature environments increases, it is important to understand how this environment affects the workers and the challenges it may present.

This review evaluates how working in cold …


Hubungan Diabetes Mellitus Terhadap Kejadian Disabilitas Untuk Activities Of Daily Living (Adl) Di Indonesia, Halimah Siregar, Krisnawati Bantas Dec 2020

Hubungan Diabetes Mellitus Terhadap Kejadian Disabilitas Untuk Activities Of Daily Living (Adl) Di Indonesia, Halimah Siregar, Krisnawati Bantas

Jurnal Epidemiologi Kesehatan Indonesia

Diabetes Mellitus salah satu PTM tertinggi didunia, prevalensi global diabetes di antara orang dewasa di atas 18 tahun telah meningkat dari 4,7% pada 1980 menjadi 8,5% pada 2014. Penelitian yang dilakukan Edward ditemukan bahwa> 50% orang tua dengan diabetes melaporkan kesulitan melakukan tugas fisik sehari-hari. Hal ini sejalan dengan penelitian Rindra bahwa individu yang menderita diabetes akan berisiko 3kali (95% CI; 2.860-3.288) dibandingkan individu yang tidak menderita diabetes untuk mengalami disabilitas. Tujuan penelitian ini melihat hubungan diabetes mellitus dengan kejadian disabilitas untuk aktivitas kehidupan sehari-hari (ADL). Penelitian ini desain cross sectional data IFLS 2015, di analisis sampai multivariat menggunakan Regressi …


Epidemiology Of Non-Alcoholic Fatty Liver Disease And Risk Of Hepatocellular Carcinoma Progression, Krishna Chaitanya Thandra, Adam Barsouk, Kalyan Saginala, John Sukumar Aluru, Prashanth Rawla, Alexander Barsouk Dec 2020

Epidemiology Of Non-Alcoholic Fatty Liver Disease And Risk Of Hepatocellular Carcinoma Progression, Krishna Chaitanya Thandra, Adam Barsouk, Kalyan Saginala, John Sukumar Aluru, Prashanth Rawla, Alexander Barsouk

Kimmel Cancer Center Faculty Papers

Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease worldwide. Its incidence has grown alongside the increasing global prevalence of type 2 diabetes, obesity, and metabolic syndrome. The risk of progression to hepatocellular carcinoma for nonalcoholic steatohepatitis patients over 5 years is 8%, and despite targeted and immunotherapy treatment advances, HCC maintains a bleak 5-year survival of 19%. NAFLD’s primary risk factors are components of metabolic syndrome as well as possible sleep disturbances. NAFLD is most common among men 50-60 years of age, though incidence in women catches up after menopause. In the US, Hispanics are …


Evaluasi Dampak Program Keluarga Harapan Terhadap Pemanfaatan Fasilitas Pelayanan Kesehatan Untuk Layanan Persalinan Di Indonesia (Analisis Data Susenas Tahun 2018), Gede Wirabuana Putra, Pujianto Pujianto Dec 2020

Evaluasi Dampak Program Keluarga Harapan Terhadap Pemanfaatan Fasilitas Pelayanan Kesehatan Untuk Layanan Persalinan Di Indonesia (Analisis Data Susenas Tahun 2018), Gede Wirabuana Putra, Pujianto Pujianto

Jurnal Ekonomi Kesehatan Indonesia

Program Keluarga Harapan (PKH) aims to improve the standard of living of the people as measured through the Human Development Index (IPM) and the level of inequality in expenditure of the Indonesian population (Gini Ratio) by accommodating the utilization of health services as one of the indicator. In 2018 there are still 16% of deliveries that were not performed by trained health workers at healthcare facilities. One health component that is required as a PKH Beneficiary Family (KPM) is that pregnant women are required to deliver in a health care facility. The purpose of this study is to look at …


Integration Of Cardiovascular Risk Assessment With Covid-19 Using Artificial Intelligence., Jasjit S Suri, Anudeep Puvvula, Misha Majhail, Mainak Biswas, Ankush D Jamthikar, Luca Saba, Gavino Faa, Inder M Singh, Ronald Oberleitner, Monika Turk, Saurabh Srivastava, Paramjit S Chadha, Harman S Suri, Amer M Johri, Vijay Nambi, J Miguel Sanches, Narendra N Khanna, Klaudija Viskovic, Sophie Mavrogeni, John R Laird, Arindam Bit, Gyan Pareek, Martin Miner, Antonella Balestrieri, Petros P Sfikakis, George Tsoulfas, Athanasios Protogerou, Durga Prasanna Misra, Vikas Agarwal, George D Kitas, Raghu Kolluri, Jagjit Teji, Michele Porcu, Mustafa Al-Maini, Ann Agbakoba, Meyypan Sockalingam, Ajit Sexena, Andrew Nicolaides, Aditya Sharma, Vijay Rathore, Vijay Viswanathan, Subbaram Naidu, Deepak L Bhatt Dec 2020

Integration Of Cardiovascular Risk Assessment With Covid-19 Using Artificial Intelligence., Jasjit S Suri, Anudeep Puvvula, Misha Majhail, Mainak Biswas, Ankush D Jamthikar, Luca Saba, Gavino Faa, Inder M Singh, Ronald Oberleitner, Monika Turk, Saurabh Srivastava, Paramjit S Chadha, Harman S Suri, Amer M Johri, Vijay Nambi, J Miguel Sanches, Narendra N Khanna, Klaudija Viskovic, Sophie Mavrogeni, John R Laird, Arindam Bit, Gyan Pareek, Martin Miner, Antonella Balestrieri, Petros P Sfikakis, George Tsoulfas, Athanasios Protogerou, Durga Prasanna Misra, Vikas Agarwal, George D Kitas, Raghu Kolluri, Jagjit Teji, Michele Porcu, Mustafa Al-Maini, Ann Agbakoba, Meyypan Sockalingam, Ajit Sexena, Andrew Nicolaides, Aditya Sharma, Vijay Rathore, Vijay Viswanathan, Subbaram Naidu, Deepak L Bhatt

Heart and Vascular Articles

Artificial Intelligence (AI), in general, refers to the machines (or computers) that mimic "cognitive" functions that we associate with our mind, such as "learning" and "solving problem". New biomarkers derived from medical imaging are being discovered and are then fused with non-imaging biomarkers (such as office, laboratory, physiological, genetic, epidemiological, and clinical-based biomarkers) in a big data framework, to develop AI systems. These systems can support risk prediction and monitoring. This perspective narrative shows the powerful methods of AI for tracking cardiovascular risks. We conclude that AI could potentially become an integral part of the COVID-19 disease management system. Countries, …


An Assessment Of Knowledge, Attitude, And Practice Of The Kuantan Community On The Effects Of Monosaccharides On Cancer, Muhammad Alif Mazlan, Muhammad Kamil Che Hasan, Afzan Mat Yusof, Muhammad Lokman Md Isa Dec 2020

An Assessment Of Knowledge, Attitude, And Practice Of The Kuantan Community On The Effects Of Monosaccharides On Cancer, Muhammad Alif Mazlan, Muhammad Kamil Che Hasan, Afzan Mat Yusof, Muhammad Lokman Md Isa

Makara Journal of Health Research

Background: Cancer knowledge, attitude, and practice (KAP) levels of communities are essential to be assessed to enhance cancer educational programs. This study aimed to determine the KAP level of the Kuantan community on the effects of monosaccharides on cancer. The association between the sociodemographic data and KAP level of the community has also been evaluated.

Methods: A cross-sectional survey was performed among residents living in the Kuantan community. Only 303 of 380 responses were included in the data analysis using the chi-square test.

Results: The knowledge and practice levels were moderate, whereas the attitude was at a …


Psychosocial Impacts Of Fixed Orthodontic Treatment In Lahore, Pakistan, Hazik Bin Shahzad, Dalia Iftikhar, Noor Ul Huda, Nayha Enver, Faiza Awais, Shabbir Hussain Dec 2020

Psychosocial Impacts Of Fixed Orthodontic Treatment In Lahore, Pakistan, Hazik Bin Shahzad, Dalia Iftikhar, Noor Ul Huda, Nayha Enver, Faiza Awais, Shabbir Hussain

Makara Journal of Health Research

Background: The aim of this study is to assess psychosocial impacts on oral health-related quality of life between individuals currently undergoing orthodontic treatment and those who have completed treatment.

Methods: A total of 135 individuals were selected from the Orthodontic Department at Rashid Latif Dental Hospital, Lahore, Pakistan. Current and previous orthodontic treatments were recorded. A questionnaire on oral impacts on daily performance was used to assess functional, psychological, and social limitations.

Results: The most prevalent psychosocial impact was difficulty in smiling/laughing (26.6%). Logistic regression analysis showed that individuals currently undergoing orthodontic treatment are 2.9 times more …


The Crossroads Of Wellness And Second Victim Syndrome: Identifying Factors That Alter The Pathway Of Caregiver Recovery Following An Unanticipated Adverse Patient Outcome, Kimia Zarabian, A. Katharine Hindle, Ivy Benjenk, Anita Vincent, Jamil M. Kazma, Benjamin Shambon, Raymond Pla, Eric Heinz Dec 2020

The Crossroads Of Wellness And Second Victim Syndrome: Identifying Factors That Alter The Pathway Of Caregiver Recovery Following An Unanticipated Adverse Patient Outcome, Kimia Zarabian, A. Katharine Hindle, Ivy Benjenk, Anita Vincent, Jamil M. Kazma, Benjamin Shambon, Raymond Pla, Eric Heinz

Journal of Wellness

Introduction: Second Victim Syndrome (SVS) describes the phenomenon in which a caregiver experiences a traumatic psychological and emotional response to an adverse patient event or medical error. Using quantitative survey analysis, we aim to better understand the personal factors that affect SVS development and recovery.

Methods: Caregivers at a small urban academic medical center who had experienced an adverse patient event in the past six months were invited to take part in this institution-wide, voluntary, quantitative, cross-sectional study. Three surveys were administered; the Holmes-Rahe Life Stress Inventory (HRLSI) was used as a surrogate to measure stressful life events. The …


Loss-Of-Function Genomic Variants Highlight Potential Therapeutic Targets For Cardiovascular Disease, Jonas B. Nielsen, Oren Rom, Ida Surakka, Sarah E. Graham, Wei Zhou, Tanmoy Roychowdhury, Lars G. Fritsche, Sarah A. Gagliano Taliun, Carlo Sidore, Yuhao Liu, Maiken E. Gabrielsen, Anne Heidi Skogholt, Brooke Wolford, William Overton, Ying Zhao, Jin Chen, He Zhang, Whitney E. Hornsby, Akua Acheampong, Austen Grooms, Amanda Schaefer, Gregory J. M. Zajac, Luis Villacorta, Jifeng Zhang, Ben Brumpton, Mari Løset, Vivek Rai, Pia R. Lundegaard, Morten S. Olesen, Kent D. Taylor, Donna K. Arnett Dec 2020

Loss-Of-Function Genomic Variants Highlight Potential Therapeutic Targets For Cardiovascular Disease, Jonas B. Nielsen, Oren Rom, Ida Surakka, Sarah E. Graham, Wei Zhou, Tanmoy Roychowdhury, Lars G. Fritsche, Sarah A. Gagliano Taliun, Carlo Sidore, Yuhao Liu, Maiken E. Gabrielsen, Anne Heidi Skogholt, Brooke Wolford, William Overton, Ying Zhao, Jin Chen, He Zhang, Whitney E. Hornsby, Akua Acheampong, Austen Grooms, Amanda Schaefer, Gregory J. M. Zajac, Luis Villacorta, Jifeng Zhang, Ben Brumpton, Mari Løset, Vivek Rai, Pia R. Lundegaard, Morten S. Olesen, Kent D. Taylor, Donna K. Arnett

Epidemiology and Environmental Health Faculty Publications

Pharmaceutical drugs targeting dyslipidemia and cardiovascular disease (CVD) may increase the risk of fatty liver disease and other metabolic disorders. To identify potential novel CVD drug targets without these adverse effects, we perform genome-wide analyses of participants in the HUNT Study in Norway (n = 69,479) to search for protein-altering variants with beneficial impact on quantitative blood traits related to cardiovascular disease, but without detrimental impact on liver function. We identify 76 (11 previously unreported) presumed causal protein-altering variants associated with one or more CVD- or liver-related blood traits. Nine of the variants are predicted to result in loss-of-function of …


Hips That Harm: When Medical Devices Fail Women, Sophie N. Putka Dec 2020

Hips That Harm: When Medical Devices Fail Women, Sophie N. Putka

Capstones

Medical devices that save the lives of thousands of Americans each year advance at a rapid pace - but some of them consistently leave women behind. When it comes to joint replacements and even heart devices, women have worse health outcomes. Behind this preventable problem is a system that overlooks women from start to finish. Female bodies are different from male bodies, but women are often underrepresented in medical trials for device approval. Women’s participation in clinical testing for devices has increased, but there’s rarely a detailed analysis of performance by sex, and even less information on women by race …


The Contribution Of A Global Ethics Approach To Health And The Environment In The Niger Delta Region, Augustine Wayii Dec 2020

The Contribution Of A Global Ethics Approach To Health And The Environment In The Niger Delta Region, Augustine Wayii

Electronic Theses and Dissertations

ABSTRACT

THE CONTRIBUTION OF A GLOBAL ETHICS APPROACH TO HEALTH AND THE

ENVIRONMENT IN THE NIGER DELTA REGION

By

Augustine Lezorgia Wayii, M. ED, M.A.

May 2020

Dissertation supervised by Gerard Magill, PhD

The dissertation presents a global ethics approach that connects health and the environment in the context of the Niger Delta Region. The people of the Niger Delta region in Nigeria are experiencing major catastrophes that connect health and the environment. In the bid to ameliorate these pivotal problems, this dissertation undertakes an ethical analysis that connects health and the environment. Insofar as these problems can be characteristic …


Healthcare Workers Hospitalized With Covid-19: Outcomes From The Burden Of Covid-19 Study At The University Of Louisville Center Of Excellence For Research In Infectious Diseases [Cerid], Ruth Carrico, T'Shura S. Ali, Maria Hill, Lucia B. Puga Sanchez, Catherine M. Bryan, Dawn Balcom, Stephen P. Furmanek, Amr Aboelnasr, Julio A. Ramirez Dec 2020

Healthcare Workers Hospitalized With Covid-19: Outcomes From The Burden Of Covid-19 Study At The University Of Louisville Center Of Excellence For Research In Infectious Diseases [Cerid], Ruth Carrico, T'Shura S. Ali, Maria Hill, Lucia B. Puga Sanchez, Catherine M. Bryan, Dawn Balcom, Stephen P. Furmanek, Amr Aboelnasr, Julio A. Ramirez

The University of Louisville Journal of Respiratory Infections

Introduction: On March 6, 2020, the current ongoing pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as COVID-19, reached the commonwealth of Kentucky. Within days, the first cases of infection and hospitalization were identified among healthcare workers (HCW) in Kentucky, other states in the U.S., and around the world. There is little information available regarding the impact of COVID-19 on the HCW population within this area. The objective of this study was to describe the baseline characteristics of hospitalized HCWs infected with COVID-19.

Methods: Data collection was performed as part of a retrospective study of patients hospitalized …


Open Drug Discovery Of Anti-Virals Critical For Canada’S Pandemic Strategy, Tania M. Bubela, E. Richard Gold, Vivek Goel, Max Morgan, Karen Mossman, Jason Nickerson, David Patrick, Aled Edwards Dec 2020

Open Drug Discovery Of Anti-Virals Critical For Canada’S Pandemic Strategy, Tania M. Bubela, E. Richard Gold, Vivek Goel, Max Morgan, Karen Mossman, Jason Nickerson, David Patrick, Aled Edwards

Office of the Provost

In the event of the current COVID-19 pandemic and in preparation for future pandemics, open science can support mission-oriented research and development, as well as commercialization. Open science shares skills and resources across sectors; avoids duplication and provides the basis for rapid and effective validation due to full transparency. It is a strategy that can adjust quickly to reflect changing incentives and priorities, because it does not rely on any one actor or sector. While eschewing patents, it can ensure high-quality drugs, low pricing, and access through existing regulatory mechanisms. Open science practices and partnerships decrease transaction costs, increase diversity …


Gender Variations In Neonatal And Early Infant Mortality In India And Pakistan: A Secondary Analysis From The Global Network Maternal Newborn Health Registry, Zubair H. Aghai, Shivaprasad S. Goudar, Archana Patel, Sarah Saleem, Sangappa M. Dhaded, Avinash Kavi, Parth Lalakia, Farnaz Naqvi, Patricia L. Hibberd, Elizabeth M. Mcclure Dec 2020

Gender Variations In Neonatal And Early Infant Mortality In India And Pakistan: A Secondary Analysis From The Global Network Maternal Newborn Health Registry, Zubair H. Aghai, Shivaprasad S. Goudar, Archana Patel, Sarah Saleem, Sangappa M. Dhaded, Avinash Kavi, Parth Lalakia, Farnaz Naqvi, Patricia L. Hibberd, Elizabeth M. Mcclure

Community Health Sciences

Background: To determine the gender differences in neonatal mortality, stillbirths, and perinatal mortality in south Asia using the Global Network data from the Maternal Newborn Health Registry.
Methods: This study is a secondary analysis of prospectively collected data from the three south Asian sites of the Global Network. The maternal and neonatal demographic, clinical characteristics, rates of stillbirths, early neonatal mortality (1-7 days), late neonatal mortality (8-28 days), mortality between 29-42 days and the number of infants hospitalized after birth were compared between the male and female infants.
Results: Between 2010 and 2018, 297,509 births [154,790 males (52.03%) and 142,719 …


Oral Chemotherapy: Safe Handling In The Home, Cynthia Huff Dec 2020

Oral Chemotherapy: Safe Handling In The Home, Cynthia Huff

DNP Qualifying Manuscripts

Background: According to the National Institute for Occupational Safety and Health (2016), oral anticancer agents (OAC) are hazardous drugs (HD) and require the same safe handling interventions in the home setting as in controlled health care environments. The use of a safe handling checklist for OAC administration is a way nurses can provide safe handling education to patients and caregivers and assess for understanding and competency for critical tasks. Effective home management strategies outlining caregiver protections, proper storage, administration of OACs, spill clean-up, and waste disposal could reduce exposure risks to toxic agents.

Objective: To present a safe-handling checklist …


Africans Who Arrive In The United States Before 20 Years Of Age Maintain Both Cardiometabolic Health And Cultural Identity: Insight From The Africans In America Study, Elyssa M. Shoup, Thomas Hormenu, Nana H. Osei-Tutu, M.C. Sage Ishimwe, Arielle C. Patterson, Christopher W. Dubose, Annemarie Wentzel, Margrethe F. Horlyck-Romanovsky, Anne E. Sumner Dec 2020

Africans Who Arrive In The United States Before 20 Years Of Age Maintain Both Cardiometabolic Health And Cultural Identity: Insight From The Africans In America Study, Elyssa M. Shoup, Thomas Hormenu, Nana H. Osei-Tutu, M.C. Sage Ishimwe, Arielle C. Patterson, Christopher W. Dubose, Annemarie Wentzel, Margrethe F. Horlyck-Romanovsky, Anne E. Sumner

Publications and Research

The overall consensus is that foreign-born adults who come to America age < 20 y achieve economic success but develop adverse behaviors (smoking and drinking) that lead to worse cardiometabolic health than immigrants who arrive age ≥ 20 y. Whether age of immigration affects the health of African-born Blacks living in America is unknown. Our goals were to examine cultural identity, behavior, and socioeconomic factors and determine if differences exist in the cardiometabolic health of Africans who immigrated to America before and after age 20 y. Of the 482 enrollees (age: 38 ± 1 (mean ± SE), range: 20–65 y) in the Africans in America cohort, 23% (111/482) arrived age < 20 y, and 77% (371/482) arrived age ≥ 20 y. Independent of francophone status or African region of origin, Africans who immigrated age < 20 y had similar or better cardiometabolic health than Africans who immigrated age ≥ 20 y. The majority of Africans who immigrated age < 20 y identified as African, had African-born spouses, exercised, did not adopt adverse health behaviors, and actualized early life migration advantages, such as an American university education. Due to maintenance of cultural identity and actualization of opportunities in America, cardiometabolic health may be protected in Africans who immigrate before age 20. In short, immigrant health research must be cognizant of the diversity within the foreign-born community and age of immigration.


Inaction On Lead Despite The Relevant Knowledge: Predictors, Covariates, And Outreach Implications, Alessandra Rossi, Bernabas Wolde, Pankaj Lal, Melissa Harclerode Dec 2020

Inaction On Lead Despite The Relevant Knowledge: Predictors, Covariates, And Outreach Implications, Alessandra Rossi, Bernabas Wolde, Pankaj Lal, Melissa Harclerode

Department of Biology Faculty Scholarship and Creative Works

Testing residential soil and paint for lead provides actionable information. By showing where and how much lead exists on the residence, it allows one to quantify risk and determine the best ways to reduce exposure along with the corresponding health and financial costs. For these reasons, several federal and state programs offer outreach to audiences on the benefits of testing residential soil and paint for lead. Not all individuals who know about lead’s adverse health effects, however, test their residence for lead, potentially limiting the actionable information that could have helped to reduce their exposure. Such individuals represent a challenge …