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Blood Metabolites Predicting Mild Cognitive Impairment In The Study Of Latinos-Investigation Of Neurocognitive Aging (Hchs/So), Shan He, Einat Granot-Hershkovitz, Ying Zhang, Jan Bressler, Wassim Tarraf, Bing Yu, Tianyi Huang, Donglin Zeng, Sylvia Wassertheil-Smoller, Melissa Lamar, Martha Daviglus, Maria J Marquine, Jianwen Cai, Thomas Mosley, Robert Kaplan, Eric Boerwinkle, Myriam Fornage, Charles Decarli, Bruce Kristal, Hector M Gonzalez, Tamar Sofer

Faculty, Staff and Student Publications

INTRODUCTION: Blood metabolomics-based biomarkers may be useful to predict measures of neurocognitive aging.

METHODS: We tested the association between 707 blood metabolites measured in 1451 participants from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), with mild cognitive impairment (MCI) and global cognitive change assessed 7 years later. We further used Lasso penalized regression to construct a metabolomics risk score (MRS) that predicts MCI, potentially identifying a different set of metabolites than those discovered in individual-metabolite analysis.

RESULTS: We identified 20 metabolites predicting prevalent MCI and/or global cognitive change. Six of them were novel and 14 were previously reported as …

Incidence Rate Of Psychiatric Disorders In 2020: The Pivotal Role Played By Sars-Cov-2 Infection, Antonio L Teixeira, Regina M Hansen, Joseph S Wozny, Caroline M Schaefer, Rodrigo Machado-Vieira, Lokesh Shahani, Scott D Lane, Jair C Soares, Trudy M Krause

Faculty, Staff and Student Publications

IMPORTANCE: The Coronavirus Disease (COVID-19) pandemic has significantly impacted mental health outcomes. While the frequency of anxiety and depressive symptoms has increased in the whole population, the relationship between COVID-19 and new psychiatric diagnoses remains unclear.

OBJECTIVE: to compare the population incidence rate of emergence of de novo psychiatric disorders in 2020 compared to the previous years, and to compare the incidence rate of new psychiatric disorder diagnoses between people with vs without COVID-19.

DESIGN, SETTING, AND PARTICIPANTS: This study utilized administrative claims data from the Clinformatics® Data Mart database, licensed from Optum®. The study is a cross-sectional analysis that …

Strategies For Preventing And Mitigating Counterfeit Medication From Entering The U.S. Supply Chain, Denise Blais

Walden Dissertations and Doctoral Studies

Some pharmaceutical brand protection managers lack strategies to mitigate financial losses from counterfeit prescription drugs. A multilayered approach involving guiding principles, supply chain security, investigations, enforcement, advocacy, and awareness can help mitigate potential financial losses and keep patients safe. Guided by the Six Sigma define, measure, analyze, improve, and control (DMAIC) model and the fraud triangle conceptual framework, the purpose of this multiple case study was to explore strategies brand protection managers use to mitigate financial losses from counterfeit prescription drugs. Data collection included three semi-structured interviews using Zoom. Analyzing data entailed transcribing and coding themes within data and relating …

Factors That Predict Prescription Opioid Misuse By Type Of Healthcare Insurance Coverage, Keon Green

Walden Dissertations and Doctoral Studies

The opioid epidemic remains one of the leading causes of unintended deaths in the United States and is still one of the focal points of the public health field. Previous research has increased awareness of the opioid crisis and has focused on sociodemographic factors that may cause or predict prescription opioid misuse. The purpose of this study was to investigate sociodemographic factors that may predict prescription opioid misuse while controlling for healthcare insurance. The theoretical foundation for this secondary data analysis project was the socioecological model using the 2019 National Survey on Drug Use and Health. The population was 56,136 …

Gender And Risk Behaviors Association With Hepatitis-B Infections Among Liberia Military Personnel, Joseph B N Kowo Jr

Walden Dissertations and Doctoral Studies

The increasing number of hepatitis B-related deaths in the Armed Forces of Liberia was due to the lack of understanding of the associated risks with the disease. Gender, substance use, and condom use have been researched as related risk factors for hepatitis B virus infection (HBV). The goal of this study was to determine if gender (male or female) and risk factors (substance use, alcohol abuse, and condom use) predicted hepatitis B infections after adjusting for age, marital status, education, and military rank among Liberia military population. The theory that grounded this study was Bronfenbrenner’s socio-ecological model (SEM) which posits …

Overeating As A Coping Response To Workplace Gender Discrimination: The Role Of Resilience And Social Support, Rosemarie Charmain Mitchell

Walden Dissertations and Doctoral Studies

Gender discrimination in the workplace continues to be a persistent source of stress for women even after 5 decades of antidiscrimination legislation in the United States. Women are more likely than men to cope with stress by overeating, which is a risk factor for chronic illnesses and obesity. Much less is known about the protective factors that could weaken the association between perceived stress and overeating. The purpose of this quantitative study was to address this gap in the literature by examining whether resilience and social support are moderators of the overeating response for women who have experienced gender discrimination …

School Lunch Timing And Student Body Mass Index, Megan Monteith

Walden Dissertations and Doctoral Studies

Obesity continues to be a leading public health issue in the United States. Many chronic diseases are associated with obesity, including hypertension, diabetes, and several forms of cancer. There are multiple known contributing factors to obesity; however, historically, there has been little research focusing on time of day eating as a possible risk factor for obesity, especially childhood obesity. Childhood obesity is a significant risk factor for adult obesity. Obese children and adolescents are five times more likely to be obese in adulthood. The theoretical foundation for this study was the social ecological model. In this secondary correlational analysis using …

Educating Nurse Practitioners On Factors Associated With Compassion Fatigue, Alicia Moonesar

Walden Dissertations and Doctoral Studies

Nurse Practitioners (NPs) across Canada continue to endure the escalating demands of increasing patient workloads, the deficiency of inadequate resources, and the paucity of leadership support. The ongoing exposure to these and other challenges often contributes to a complex work environment that may result in compassion fatigue (CF). CF can be operationally defined as a state of exhaustion and dysfunction because of prolonged exposure to compassion stress and all that it evokes. The need for education and prevention of CF is critical as the prevalence of CF is on the rise. Guided by Watson’s Theory of Human Caring and Benner’s …

Disparities In Cervical Cancer Survival Amongst White And African American Women, Lucius Amandi-Tasie Ogoke

Walden Dissertations and Doctoral Studies

Cervical cancer disproportionately impacts racial and ethnic minorities in the United States. The continuum in the disturbing morbidity and mortality trends declined markedly in 2020. However, there are more than 13,000 diagnosed cases, and almost 4,300 related deaths, and significant racial disparities in cervical cancer survival persist. The socio-ecological model served as the theoretical framework. Chi-square tests and binary logistic regression analyses were used to analyze data from the National Cancer Institute Surveillance, Epidemiology, and Ends Results Summary. The purpose of the study was to assess the association between race/ethnicity-related disparities in sociodemographic, histopathological, and treatment-related factors and cervical cancer …

Variables On The Proportion Of Children With Sickle Cell Hemoglobin, Oyekola Oluyimika Oloyede

Walden Dissertations and Doctoral Studies

AbstractThe case fatality rate among children living with sickle cell disease was approximately 50% to 90% in Sub-Saharan Africa. Though researchers have contributed social determinants of health more broadly, they have not provided adequate screening information on children living with sickle cell disease aged 6 months to 59 months. The purpose of this cross-sectional study was to examine the association between sickle cell disease status, infection prevention, pain and anemia management, demography, socioeconomic status, and healthcare use. This study included approximately 11,536 genotype results of children under 5-years-old in Nigeria. Bronfenbrenner’s systems theory and Krieger’s ecological theory formed the theoretical …

Sociodemographic And Behavioral Predictors Of Obesity Among Female Asian Indian Immigrants In The United States, Afiya Saleem

Walden Dissertations and Doctoral Studies

Individuals from low-income countries such as those in the Asian region migrate to high-income countries and adopt obesogenic behaviors like sedentary lifestyles and high fat and sugar intake. This results in increased susceptibility to obesity, diabetes mellitus, cardiovascular disease, and stroke. Previous research has demonstrated that migrants from South Asian countries are at an increased risk of developing obesity, type 2 diabetes, and hypertension; however, little is known about the factors that contribute to this phenomenon. This was a quantitative, cross-sectional study guided by the social-ecological model. This study used secondary data from the National Health Interview survey to investigate …

Public Safety Personnel And The Use Of Peer-To-Peer Mental And Emotional Support Through Social Media, Tiffany R. Shinton-Truitt

Walden Dissertations and Doctoral Studies

The emotional and mental health of public safety personnel has been a topic that is continuing to receive attention. Being exposed to multiple traumatic events takes a mental and emotional toll on those who place their lives in harm’s way to help others. The study was based on social cognitive theory which focused on self-efficacy through social influences and environment. The purpose of this study was to understand the experience of public safety personnel’s training regarding their perceptions to mitigate emotional stress; the experience of public safety personnel with seeking mental health services; experience of public safety personnel with the …

Impact Of Poverty On Antibiotic Prescribing Rates In The United States Through Mediation Effects Of Underlying Health Conditions, Nato Tarkhashvili

Walden Dissertations and Doctoral Studies

Resistance to antibiotics among bacteria develops largely due to frequent use of antibiotics in human and animal medicine. Little is known about how patients’ socioeconomic factors, in conjunction with chronic health conditions, impact antibiotic prescribing rates in the United States. The research questions aimed to explore the relationship between poverty and antibiotic prescribing rates while also adjusting for confounders such as population aged ≥ 65, physician density, prevalence of obesity, diabetes, and chronic obstructive pulmonary disease (COPD). The relationships were evaluated using a quantitative, ecological study design using the ecosocial theory and mediation analysis of 2020 survey results provided by …

Vitamin K Deficiency And Ischemic Stroke In Atrial Fibrillation Patients On Warfarin, Kimberly Therese Thompson

Walden Dissertations and Doctoral Studies

Individuals with poor nutritional vitamin K status can suffer from atrial fibrillation (AF) due to misinterpretation of warfarin instructions by healthcare providers. The purpose of this quantitative study was to determine if there was an association between inadequate dietary vitamin K intake in AF patients and stroke outcomes to address the lack of research surrounding stroke outcomes in patients with true vitamin K deficiency. Grounded in the health belief model, this study assessed if individual beliefs from health education influenced the nutritional quality of their diet and health outcomes. The study is a secondary data analysis of the Framingham Heart …

Perceived Diabetes Susceptibility Among African American Female College Students, Khaliah India Wilson

Walden Dissertations and Doctoral Studies

Type 2 diabetes is a leading cause of death among African American women ages 20-44 years, and African American female college students are at high risk. Research shows that college students tend to underestimate their susceptibility to Type 2 diabetes, despite their existing risk factors. There is a gap in knowledge concerning African American female college students and their perception of diabetes susceptibility, despite their increased risk. The purpose of this quantitative nonexperimental, correlational study was to identify the factors associated with perceived personal susceptibility to Type 2 diabetes and Type 2 diabetes-related health behavior among African American female college …

Treatment-Seeking Behaviors And Malaria Prevalence Among Under-5 Children In Niger, Aissa Yaye Habi

Walden Dissertations and Doctoral Studies

Malaria is a deadly vector-borne disease that mainly affects children in Africa, especially in Niger. Although public health efforts in malaria prevention have been successful in many parts of the world, malaria remains a significant public burden in sub-Saharan Africa, especially among children. Despite the numerous studies conducted on individual factors influencing the prevalence of malaria in sub-Saharan Africa and Niger, there is little knowledge about the collective influence of treatment-seeking behaviors and malaria prevalence among under-5 children in Niger. This study was a quantitative study with a cross-sectional design guided by the social-ecological model (SEM) that used secondary data …

Gestational Weight Gain, Level Of Education, And Infant Mortality Among African American Women, George Lee Amanambu

Walden Dissertations and Doctoral Studies

Abstract

African American (AA) women in Mississippi have a higher burden of infant mortality, especially those with low income and educational levels, as compared to other regions of the country. However, it is unknown if abnormal gestation weight gain (GWG) is contributing to this increased burden. This quantitative cross-sectional study examined the association between GWG (25-35lbs), level of education, income, and infant mortality among AA women with normal prepregnancy body weight who were between 30 to 47 years old in the state of Mississippi from 2016 to 2018. Biopsychosocial and ecosocial models were used as the theoretical foundation to design …

Weight Change And Hyponatremia As Predictors Of Polydipsia Among Persons With Schizophrenia, Kingsley Okechukwu Nwachukwu

Walden Dissertations and Doctoral Studies

AbstractPolydipsia is found in 20% of inpatients with chronic severe mental disorders. Of this, 80% are diagnosed with chronic schizophrenia, hence polydipsia is strongly associated with chronic schizophrenia. Despite the prevalence and serious health complications of coexisting polydipsia in this population, its current method of detection is flawed. The purpose of this quantitative study was to accurately identify comorbid polydipsia in schizophrenia using periodic weight change and hyponatremia. The Wilson’s complexity theory and primary data were used to attempt to explain the relationship between weight change and hyponatremia and polydipsia, in a cross-sectional study design. The dependent variable was polydipsia, …

Depression, Drug Use, And Hsv-2 Among Women Who Have Sex With Women, Viani Picchetti

Walden Dissertations and Doctoral Studies

Herpes simplex virus type 2 (HSV-2), the main cause of genital herpes, is an incurable sexually transmitted infection responsible in 2018 for 18.6 million infections in the United States. HSV-2 is twice as frequent in women than in men. Women who have sex with women (WSW) have a higher prevalence of depression and drug use than women who have sex exclusively with men (WSM), which are each related to HSV-2 as they increase the likelihood of engaging in risky sexual behaviors. The purpose of this study was to assess the predictive relationship between depression status, nonprescription drug use status, and …

Diabetes, Obesity, Geographic Location Of The Patient And Clostridium Difficile Infection In The United States, Mary (Maribeth) Greenway

Walden Dissertations and Doctoral Studies

AbstractClostridium difficile infection (CDI) is a major nosocomial threat to be reckoned with in the current health care setting in the United States. Advancing age, underlying chronic disease associated with inflammation (including Diabetes Mellitus Type I ([DMI]), Diabetes Type II ([DMII]), and obesity), trauma, immunodeficiency and other factors that diminish the overall health of an individual, and increase an individual’s susceptibility to CDI. The ecological framework was used to determine the relationship between geographic, chronic diseases and the occurrence of infectious diseases. To continue enhancing knowledge related to CDI susceptibility this quantitative study used the 2010 National Hospital Discharge Survey …

Bullying, Participation In Violence, Suicidal Ideation, And Behavior Among African American Youth, Kierystan Lorquoyea Johnson

Walden Dissertations and Doctoral Studies

Suicide is the second leading cause of death among adolescent, teens, and young adults. Suicidal ideation is a predictor of suicide attempts. Guided by the integrated motivational-volitional model and social cognitive theory, Youth Risk Behavior Surveillance Survey data were used to investigate whether traditional bullying, cyberbullying, and participation in physically violent behavior (independent variables) were associated with suicidal ideation and behavior (dependent variables) among African American high school aged youth controlling for age, gender, physical, and sexual abuse. It was found that experiencing traditional bullying increased suicidal ideation significantly, as there is an 82% increase in likelihood. There was also …

Stigma And Discrimination’S Effect On Hiv Testing Of Pregnant Women In Nigeria, Charles Echezona Nzelu

Walden Dissertations and Doctoral Studies

The utilization of HIV testing services among pregnant women in Nigeria has not been optimal. Although much is known about the determinants of HIV testing among pregnant women, there is a gap in knowledge on determinants for pregnant women infected with the virus, specifically whether stigma and discrimination are barriers. The purpose of this study was to examine the effect of stigmatizing attitudes and personal knowledge of discriminatory practices towards persons living with HIV/AIDS on the decision by pregnant Nigerian women aged 15-49 years to test for HIV during antenatal visits or childbirth. The health belief model served as the …

Evaluating The 2012 Vaccination Reporting Mandate: Applications To Adventist Health Network, May Abdalla

Walden Dissertations and Doctoral Studies

Influenza is a public health concern that claims up to 56,000 lives annually in the United States, though it is a vaccine-preventable disease. Influenza vaccination among health care personnel (HCP) is highly encouraged to prevent influenza transmission in health care settings. The objective of this study was to examine the relationship between mandatory reporting of HCP influenza vaccination rates (implemented in 2012) and HCP influenza vaccination intake in a health care network with 20 hospitals. The protection and motivation theory was used as the theoretical framework. Data collected from surveys of hospital administrators and archives of the Center for Medicare …

Preconception Protective Factors Associated With Preterm Birth In Black/African American And Non-Hispanic White Women In Nyc, Joyce Yvonne Hall

Walden Dissertations and Doctoral Studies

Racial disparities in preterm birth have persisted during the past two decades. Though studies have delineated the medical, behavioral, and social risk factors explaining racial disparities in preterm birth, less is known about protective factors. This quantitative, correlational study was conducted to examine the prevalence, association, and risk of preconception health protective factors and sociodemographic covariates between Black/African American and non-Hispanic White women with preterm birth in New York City (NYC). The maternal and child health (MCH) life course approach was the theoretical foundation. The NYC Pregnancy Risk Assessment Monitoring System 2016–2018 Phase 8 survey data, which included 2,161 women …

Association Between Family Structure And Childhood Obesity In Essex County, Nj., Chima Tony Onyeagoro

Walden Dissertations and Doctoral Studies

Obesity is one of the most prevalent nutritional disorders in children in the United States. There are many factors associated with childhood obesity, but there is limited information about the association between family structure and childhood obesity. This quantitative retrospective cross-sectional study, guided by the Social Ecological Model, was carried out to identify the effect of family structure on childhood obesity. For this study, the 2017 National Survey of Children’s Health (NSCH) of children 6-13 years old residing in the state of New Jersey was analyzed. Binary logistic regression was used to determine the relationship between family structure and obesity, …

Children's Body Mass Index Before And After Covid-19 Related Childcare Center Closures, Ericka L. Peterson

Walden Dissertations and Doctoral Studies

Prolonged childcare center closures due to COVID-19 restrictions have changed children’s health-related behaviors that may result in an increased risk in childhood obesity. Grounded in the social ecological model, the purpose of this study was to examine the differences in body mass index (BMI), physical activity, consumption of sugar-sweetened beverages (SSBs), and screen time among preschool aged children enrolled in the Merced County Office of Education Head Start program before and after COVID-19 related Head Start center closures. A quantitative, longitudinal study design using secondary data from ChildPlus was used. The paired t-test and Wilcoxon signed-rank test was used to …

Treatment Outcomes And Associated Factors In Tb/Hiv-Coinfected Patients In Namibia, Esland Shilongo

Walden Dissertations and Doctoral Studies

AbstractHIV and TB have merged into a deadly co-epidemic in Namibia. Currently, though, TB and HIV data at the national, regional, and district level might be underreported and insufficient to understand the full burden and outcome rates of TB and HIV. Targeting the TB outcomes rate among TB/HIV-coinfected individuals is an effective strategy for decreasing future TB burden and furthering the gains in the control of both diseases. The objective of this study was: to assess the outcomes of patients registered for anti-TB treatment in //Karas Region which has the largests burden of TB in Namibia. A 5-year retrospective cohort …

Prophylactic Antimalarial Intermittent Preventive Therapy In Pregnancy And Birth Weight In Togo, Epiphane Awokou

Walden Dissertations and Doctoral Studies

In Togo, prophylactic antimalarial intermittent preventive therapy in pregnancy (IPTp) is provided to disrupt suboptimal pathways leading to the issue of low birth weight. However, there is a lack of nationally representative data on the determinants of this adverse birth outcome. The purpose of this quantitative cross-sectional study was to determine pregnancy-related determinants of low birth weight through a nationally representative dataset. Bronfenbrenner’s ecological systems model guided this study to explore potential associations between the covariates IPTp, utilization of long-lasting insecticidal bed nets, age of pregnant women, socioeconomic status of pregnant women, and gravidity type of pregnant women and the …

Assessing Violence And Mental Health With The 2019 Nevada Youth Risk Behavioral Survey, Samantha Graham

Walden Dissertations and Doctoral Studies

The effects from childhood trauma can interfere in all aspects of a child’s life, including their education. School delivery systems need to be trained to identify these risks and how to reduce further risks of re-traumatization by applying trauma-informed practices. This study addressed the impact of adverse childhood experiences (ACEs) on mental health and behavioral issues. The study was guided by Bandura’s social cognitive theory and the socioecological model. The correlation between ACEs and mental health as well as ACEs and physical violence were examined based on data from the 2019 Nevada Youth Risk Behavioral Survey, which was a high …

Marijuana Legalization And Depression Effects On Marijuana Use In African American Late Adolescents, Anthony Olusegun Iroko

Walden Dissertations and Doctoral Studies

State medical marijuana legalization (MML) may contribute to increased cannabis use among older adolescents, especially African American youth and adolescents with depression. This quantitative cross-sectional correlational study, which utilized Smart’s availability-proneness theory of drug use as a guiding framework, had a two-fold purpose: to determine if state MML status and self-reported depression were significantly related to past-month marijuana use and to assess if state MML status significantly moderated between depression and past-month marijuana use. The study utilized data from 1,391 African American late adolescents (aged 16-20) who participated in the 2018 National Survey on Drug Use and Health. Binary logistic …