Digital Commons Network^™

Infertility: An Evaluation Of Treatment Modalities And Ethical Considerations, Elise Ferenczy

Senior Honors Theses

This thesis reviews a variety of options for treatment of infertility, along with ethical considerations for each. The basis for ethical concerns will be primarily a biblical worldview, as the goal is to support Christian couples in decisions regarding infertility treatment. The biblical worldview is outlined to provide readers with an understanding of its core principles, and the Bible is used as the primary source for ethical discussion. The most common etiologies of infertility are outlined, followed by treatment modalities grouped by category. While some modalities present very few ethical concerns, others require careful consideration in many regards. Many of …

Pandemic Review: South Los Angeles, Madeline Carmella Acosta

Whittier Scholars Program

IMPORTANCE The COVID-19 pandemic has deepened the discussion on social inequality and vulnerabilities of the Black, Indigenous, and People of Color (BIPOC) community. The understanding is that inequality is a multifaceted issue that stems from the historical mistreatment of BIPOC individuals—their sociodemographic and economic backgrounds are at the most risk in population studies. Many predictors of contracting COVID-19 included employment status (ability to work from home), education level, income (wealth), and housing conditions (environment) (Rozenfeld et al., 2020). Contracting COVID-19 in South Los Angeles was more likely to happen among those from racial and ethnic minorities and those living in …

Antimicrobial Resistance In Eskape Pathogens And Its Effect On Modern Medicine And Treatment, Cameran Runge

Honors Program: Senior Projects (Public)

Abstract

ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella

pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter

spp.) are seeing a growing resistance to multiple classes of antibiotics. Misuse and overuse of antibiotics have played directly into the resistance observed, and the problem is growing exponentially. Antibiotic resistance is partially due to several intrinsic factors limiting the drug's uptake. These include efflux pumps, increased biofilm production, and reduced cell wall permeability in the resistant bacteria. ESKAPE pathogens also acquire resistance through horizontal gene transfer and plasmids. As antibiotics have become less effective, the bacteria can continue to thrive, leading to a detrimental …

Synthetic Or Not: Implications Of Hormonal Birth Control On Women’S Hormones And The Cortisol Stress Response, Maddie Perry '23

Honor Scholar Theses

Women’s bodies are the subject of decision-making and control, yet women’s lives are dismally ignored. The field of women’s health is highly understudied, and the demand for that adequate research must be granted to the women’s health field. This interdisciplinary research study investigated stress response differences between hormonal birth control users and non-users. Hormonal birth control (HBC) is one of the greatest technologies afforded to women and further research is necessary to ensure women are guaranteed bodily autonomy and women’s health education. Due to altered hormonal signaling, HBC has been linked to behavioral and decision making differences in women. Building …

The Negative Influence Of External Stressors On Patient Outcomes: Why Physicians Should Consider More Than Outwardly Presenting Symptom(S), Gianna Meckler '23

Honor Scholar Theses

In this thesis, the influence of external stressors on patient health outcomes in the medical setting will be examined. There is an overwhelming amount of reputable research that suggests that the American healthcare system, at least as it operates now, does not effectively improve patient health outcomes. Simply focusing on outwardly apparent illness or disease does not address the full scope of patient need. Ample evidence will be provided in the form of a comprehensive literature review accompanied by supporting anecdotes from real physicians in hopes of encouraging healthcare professionals to increase the breadth of their considerations when it comes …

Implementation And Evaluation Of Obesity Management Tools, Hunter Wayne Turnipseed

Open Access Theses & Dissertations

The demand for obesity treatment and management cannot be met because of the lack of obesity specialists. Therefore, integrating obesity management tools in primary care is an excellent option for obesity treatment. Also, the importance of DPP as a scalable community-based program and that Small Changes provides a structured dietary approach that we hypothesize will improve weight loss outcomes. These two studies evaluated the implementation of obesity management tools in primary care clinics in the Paso del Norte area and a DPP program in Brownsville, TX. The first study explored the key facilitators and barriers to adopting the CDSS and …

Mental Illness And Substance Use Disorder (Sud) Among Pregnant And Postpartum Women In A Women's Residential Treatment Center In El Paso, Texas, Adren Darius Warling

Open Access Theses & Dissertations

Background: Substance use disorders (SUDs) and opioid use disorders (OUDs) are a major public health concern in the United States. SUD/OUDs are often linked to co-occurring physical disorders and serious mental illness (SMI). Stress and trauma are often contributing factors to the development of SUD/OUD and/or co-occurring SMI, which impact pregnant and postpartum women (PPW), who concurrently, may face specific risk factors and barriers to care for these conditions. These risk factors and barriers to care may be exacerbated by Hispanic/Latino identities. Studying social determinants of health based on a social ecological model approach can help increase knowledge about this …

Louisiana's 2023 Legislative Session: Bills Impacting Lgbtq+ And Public Health, Adrienne Katner, Harold Paul Katner

Journal of the Louisiana Public Health Association

No abstract provided.

Vol 3 May '23 Full Issue, Donna L. Williams

Journal of the Louisiana Public Health Association

No abstract provided.

Hybrid Group Mentorship For Youth Impacted By Familial Substance Use Disorder, Stephen Phillippi, Helen Lindau, Casey L. Thomas, Kaylin Beiter, Ashley Fenton, Michelle Lawrence Bidwell, Claudia Leonardi, Edmond Bowers

Journal of the Louisiana Public Health Association

Background: Children under the care of individuals with substance use disorders (SUDs) are themselves at risk for developing SUDs and delinquent behavior. Mentorship can be protective for these youth. This preliminary program evaluation study, following a descriptive cross-sectional design, describes Camp Mariposa, a novel peer and group mentoring program for youth affected by familial substance use. Methods: Data were collected from participants across 13 mentoring sites nationwide, with one site in Louisiana. These data include demographics and self-reported information about substance use, juvenile judicial system involvement, and experiences in the mentoring program. Results: Data on 570 youth participants (52% male …

A Review Of Staphylococcus Aureus Pathogenesis, Global Impact, And The Rise Of Antibiotic-Resistant Clones, Anders Kleinbeck

Honors Scholar Theses

Staphylococcus aureus is a pathogen of grave concern to global public health. The pathogen has shown an unrivaled propensity to obtain resistance to nearly every antibiotic drug approved and prescribed for its treatment. This review will provide an overview of the history and evolution of S. aureus, including an analysis of its transition from the nosocomial setting to the community and the factors contributing to the species’ innate pathogenicity. This paper will also discuss the molecular mechanisms by which resistance to a wide range of popular antibiotic substances was obtained and will provide insight into the evolutionary patterns exhibited by …

A Review Of Health Wearable-Based Physical Activity Interventions Among Children And Adolescents, Suryeon Ryu, Pablo Rodriguez-Gonzalez, Zan Gao

International Journal of Physical Activity and Health

Health wearable technologies have become popular in recent decades to improve individual physical activity (PA) behavior. Thus, this paper aims to examine the health of wearable-based PA intervention among children and adolescents and provide narrative overviews. This paper retrieved articles based on the following inclusion criteria: (1) experimental design; (2) studies among healthy children and adolescents aged from 5 to 18 years; (3) studies using health wearables as a medium to enhance PA or reduce sedentary behavior; and (4) studies with PA assessments as an outcome. Relevant articles were searched based on recent preceding review papers published in 2021 and …

A Review On The Dose Response Effect Of Regular Physical Activity On Cognitive Function Among Children And Adolescents, Weidong Li, Ping Xiang

International Journal of Physical Activity and Health

Purpose: Positive effects of physical activity on cognitive function among children and adolescents have been observed in previous studies. However, little is known about whether there is a dose-response effect of physical activity on cognitive functioning. Especially, the curvilinear relationship between regular physical activity and cognitive functioning remained unexplored. The purpose of this paper was to review the literature on the dose response effect of physical activity on cognitive function among children and adolescents. Methods: A literature search on key words, title, and abstract with the phrases “physical activity and executive function”, “physical activity and cognition”, and “physical …

Artificial Intelligence In Continuous Kidney Replacement Therapy, Lucas J. Liu, Tomonori Takeuchi, Jin Chen, Javier A. Neyra

Markey Cancer Center Faculty Publications

Over the past decade, artificial intelligence (AI) through machine learning (ML) has been increasingly used in health care applications. The use of AI/ML to enhance the provision of continuous kidney replacement therapy (CKRT) is an area of active investigation because of the growing clinical needs of critically ill patients and the abundance of multimodal data from the electronic health records (EHRs) and the CKRT machine itself. Importantly, best clinical practices of CKRT have not been sufficiently standardized, so there is considerable heterogeneity in utilization and deliverables. In this context, AI/ML-based tools could facilitate informed decisions to enhance CKRT goal-oriented deliver- …

Identification Of Molecular Markers Associated With Copd In Non-Smokers And Smokers: A Bioinformatics Analysis, Agede O. Ayodele, Isa M. Wasagu, Ademola E. Fawibe, Alakija K. Salami

The University of Louisville Journal of Respiratory Infections

Background

Even though the proportional burden of COPD among never-smokers is significant in both developing and developed nations, accounting for around 30% of all COPD in the community, there is little awareness of the prevalence of COPD in this population. Understanding the molecular processes that underlie COPD in nonsmokers is essential.

Methods

Dataset (GSE146560) was acquired from the Gene Expression Omnibus (GEO). The limma and clusterProfiler software tools were used to identify differentially expressed genes (DEGs) and conduct a functional enrichment analysis respectively.

Results

In all, 10,583 DEGs were found, of which 1,065 were up-regulated and 9,518 were down-regulated. The …

Emerging Tick-Borne Diseases In Northeast Tennessee, Jacob Schultz

Electronic Theses and Dissertations

Tick populations have been immigrating into northeast Tennessee from east Tennessee, Kentucky, Virginia, and North Carolina. Counties in states bordering northeast Tennessee harbor tick species associated with human illness. Human diseases transmitted by ticks include ehrlichiosis, spotted fever rickettsial group diseases, tularemia, anaplasmosis, babesiosis, Lyme disease, alpha-gal syndrome, Heartland virus, Powassan virus, and southern tick-associated rash illness (STARI). These diseases cause morbidity and mortality in human populations and may pose a high risk to individuals, wildlife, and livestock. The Cherokee National Forest covering the east Tennessee border provides a permissible environment for ticks to immigrate and thrive. Residents of northeast …

Covid-19 Challenges, Responses, And Resilience Among Rural Black Women: A Study Protocol, Fanghui Shi, Jiajia Zhang Ph.D., Chengbo Zeng, Xiaowen Sun, Zhenlong Li, Xueying Yang, Sharon Weissman, Bankole Olatosi Ph.D., Xiaoming Li Ph.D.

Faculty Publications

Background

Timely linkage to care (LTC) is key in the HIV care continuum, as it enables people newly diagnosed with HIV (PNWH) to benefit from HIV treatment at the earliest stage. Previous studies have found LTC disparities by individual factors, but data are limited beyond the individual level, especially at the county level. This study examined the temporal and geographic variations of county-level LTC status across 46 counties in South Carolina (SC) from 2010 to 2018 and the association of county-level characteristics with LTC status.

Methods

All adults newly diagnosed with HIV from 2010 to 2018 in SC were included …

A Pathophysiological, Clinical, And Epidemiological View Of Malaria, Alyssa Watt

Senior Honors Theses

Malaria is a parasitic disease that is common among all ages in tropical and subtropical countries. Annually, there are an estimated 3.3 billion people in 97 countries at risk of contracting malaria. Malaria has been a major global health problem throughout history and is a leading cause of death and disease for many within tropical regions. In the past decade, efforts, such advances in medicine and insecticide techniques, have reduced the prevalence of malaria by 50% which suggests that the elimination of this disease is possible. With the prevalence of malaria and recent reduction, it is vital to aid in …

The Ethical Dilemmas Epigenetic Editing In Utero Presents To Christians, Victoria Hendrix

Senior Honors Theses

The development of CRISPR epigenetic editing technology was initially impactful due to its potential for disease treatment. However, despite the potential benefits of epigenetic technology, there exist ethical dilemmas surrounding its use in utero. The review of the ethical dilemmas of epigenetic editing in utero from a Christian perspective showed that research in epigenetic editing is promising, yet fraught with peril. The basic ethical issues of epigenetic editing in utero stem from its inaccuracy, lack of research concerning its effects on offspring, an incomplete understanding of gene interactions, and its connection to eugenics. The ethical concerns particularly relevant to Christians …

High Prevalence Of Vaccine-Preventable Anal Human Papillomavirus Infections Is Associated With Hiv Infection Among Gay, Bisexual, And Men Who Have Sex With Men In Nairobi, Kenya, Myo Minn Oo, Samantha Moore, Suzanne Gibbons, Wendy Adhiambo, Peter Muthoga, Naomi Siele, Maureen Akolo, Henok Gebrebrhan, Aida Sivro, Blake T. Ball

School of Nursing & Midwifery, East Africa

Background: Human papillomavirus (HPV) infection is associated with anal cancers and is more prevalent in gay, bisexual, and men who have sex with men (gbMSM), partly due to their vulnerability to HIV infection. Baseline HPV genotype distributions and risk factors can inform the design of next-generation HPV vaccines to prevent anal cancer.

Methods: A cross-sectional study was conducted among gbMSM receiving care at a HIV/STI clinic in Nairobi, Kenya. Anal swabs were genotyped using a Luminex microsphere array. Multiple logistic regression methods were used to identify risk factors for four HPV outcomes (any HPV, any HR-HPV, and 4- …

Predictors Of Hiv Molecular Cluster Membership And Implications For Partner Services, Camden J Hallmark, Charles Luswata, Natascha Del Vecchio, Christina Hayford, Ricardo Mora, Michelle Carr, Marlene Mcneese, Nanette Benbow, John A Schneider, Joel O Wertheim, Kayo Fujimoto

Faculty, Staff and Student Publications

Public health surveillance data used in HIV molecular cluster analyses lack contextual information that is available from partner services (PS) data. Integrating these data sources in retrospective analyses can enrich understanding of the risk profile of people in clusters. In this study, HIV molecular clusters were identified and matched to information on partners and other information gleaned at the time of diagnosis, including coinfection with syphilis. We aimed to produce a more complete understanding of molecular cluster membership in Houston, Texas, a city ranking ninth nationally in rate of new HIV diagnoses that may benefit from retrospective matched analyses between …

The Need For Racial And Ethnic Health Disparity Curriculum In Genetic Counseling Programs, Yusra Aziz

Dissertations and Theses (Open Access)

Racial and ethnic health disparities (REHD) exist across all organized medicine, including the spectrum of genetic counseling, particularly in genomic testing and access to care. While cultural competency and health disparities have been included as a part of the Standards of Accreditation for Genetic Counseling, there have not been previous efforts to define what topics related to REHD are most important to include in graduate program curriculum. Therefore, this study aimed to determine what topics related to REHD should be taught in genetic counseling program curriculum by assessing what topics genetic counselors (GCs) learned about and in what settings, …

Updated Analysis To Reject The Laboratory-Engineering Hypothesis Of Sars-Cov-2, Fuqing Wu

Faculty, Staff and Student Publications

A clear understanding of the origin of SARS-CoV-2 is important for future pandemic preparedness. Here, I provided an updated analysis of the type IIS endonuclease maps in genomes of alphacoronavirus, betacoronavirus, and SARS-CoV-2. Scenarios to engineer SARS-CoV-2 in the laboratory and the associated workload was also discussed. The analysis clearly shows that the endonuclease fingerprint does not indicate a synthetic origin of SARS-CoV-2 and engineering a SARS-CoV-2 virus in the laboratory is extremely challenging both scientifically and financially. On the contrary, current scientific evidence does support the animal origin of SARS-CoV-2.

Social Reproduction And Covid-19, Caroline I. Donovan

Dartmouth College Master’s Theses

As Covid-19 rips across the world we are collectively asked to examine the structures of society to see what is working and what we can change. What can we learn from the roughly 6.9 million deaths (and counting) worldwide? How can we prevent something like this from happening again? This paper follows the course of Covid-19 from its birth in Wuhan, China, to the present day of mid-April 2023. By looking at the ways in which we have reacted to the pandemic, we are able to look forward and imagine new ways of tackling future pandemics and other pressing problems …

Dna Methylation Analysis Is Used To Identify Novel Genetic Loci Associated With Circulating Fibrinogen Levels In Blood, Julie Hahn, Jan Bressler, Arce Domingo-Relloso, Ming-Huei Chen, Daniel L Mccartney, Alexander Teumer, Jenny Van Dongen, Marcus E Kleber, Dylan Aïssi, Brenton R Swenson, Jie Yao, Wei Zhao, Jian Huang, Yujing Xia, Michael R Brown, Ricardo Costeira, Eco J C De Geus, Graciela E Delgado, Dre'von A Dobson, Paul Elliott, Hans J Grabe, Xiuqing Guo, Sarah E Harris, Jennifer E Huffman, Sharon L R Kardia, Yongmei Liu, Stefan Lorkowski, Riccardo E Marioni, Matthias Nauck, Scott M Ratliff, Maria Sabater-Lleal, Tim D Spector, Pierre Suchon, Kent D Taylor, Florian Thibord, David-Alexandre Trégouët, Kerri L Wiggins, Gonneke Willemsen, Jordana T Bell, Dorret I Boomsma, Shelley A Cole, Simon R Cox, Abbas Dehghan, Andreas Greinacher, Karin Haack, Winfried März, Pierre-Emmanuel Morange, Jerome I Rotter, Nona Sotoodehnia, Maria Tellez-Plaza, Ana Navas-Acien, Jennifer A Smith, Andrew D Johnson, Myriam Fornage, Nicholas L Smith, Alisa S Wolberg, Alanna C Morrison, Paul S De Vries

Faculty, Staff and Student Publications

Background:

Fibrinogen plays an essential role in blood coagulation and inflammation. Circulating fibrinogen levels may be determined by inter-individual differences in DNA methylation at CpG sites, and vice versa.

Methods:

We performed an epigenome-wide association study (EWAS) of circulating fibrinogen levels in 18,037 White, Black, American Indian, and Hispanic participants representing 14 studies from the CHARGE consortium. Circulating leukocyte DNA methylation was measured in 12,904 participants using the Illumina 450K array, and in 5,133 participants using the EPIC array. Each study performed an EWAS of fibrinogen using linear mixed models adjusted for potential confounders. Study-specific results were combined using array-specific …

Justification And Compliance: Public Health Ethics In A Post-Covid America, Nathan Alan Turner

Undergraduate Honors Theses

The severity of the COVID-19 pandemic and the high-profile nature of the public health response make it a natural context for exploring the current state of public health ethics. This paper explores this topic from two perspectives: justification and compliance. Libertarianism and utilitarianism are two frameworks that dominate the question of how public health interventions are justified. Consequently, this paper analyzes the events of the pandemic to determine how these frameworks fared in terms of offering reliable means of justifying the interventions needed to curb the spread of COVID-19. Consideration of these events suggests that a framework centered around actionable …

Exploring Sexual And Reproductive Health Care In Central Appalachia Through The Experiences Of Transgender And Gender Non-Binary People, Chase Harless

Electronic Theses and Dissertations

Background: Transgender or nonbinary (TNB) individuals in the United States experience higher rates of sexual and reproductive health disparities when compared to their cisgender counterparts, along with lower access to care. TNB people in the south experience higher rates of disparities. Societal, interpersonal, and individual barriers contribute to these disparities in the TNB population. However, there is a paucity of research examining the sexual and reproductive health experiences of TNB people living in Central Appalachia.

Methods: An interpretive phenomenological analysis (IPA) research design was used to collect and analyze semi-structured interviews with TNB individuals living in central Appalachia regarding their …

Influences On Pregnancy: An Exploration Of Maternal Discrimination, An Alternative Model Of Prenatal Care And Health Information Online, Emily Doherty

All Dissertations

In the United States metrics of perinatal health lag far behind peer countries and is characterized by stark disparities. The studies that make up this dissertation seek to elucidate factors influencing perinatal health.

The first and second chapters provide an introduction and extensive review of the literature of factors contributing to perinatal health with specific focus on discrimination and perinatal health; group prenatal care and digital pregnancy health information. The third chapter introduces the methodology to be used by each of the following studies. Subsequent chapters are formatted as individual manuscripts, each presenting background, methodology, results, and discussion.

The fourth …

Opioid Prescribing Practice & Policy – A Study Of Medicaid Pediatric Population In South Carolina, Laksika Sivaraj

All Dissertations

Opioids are widely used as analgesics in different clinical settings, but they are also highly criticized for their downsides. Among the adult population, the addictive nature of opioids continues to be the main concern, while among young children, there are other adverse health outcomes that opioids can cause. These concerns have led the US Food and Drug Administration (FDA) and other professional bodies to discourage opioid prescribing for children. Nevertheless, opioids continue to be prescribed for children for contraindicated health conditions. The goal of this research is to assess opioid prescribing practices for the pediatric population in South Carolina (SC). …

Comprehensive Literature Review: Assessing The Impact Of Covid-19 Policies, School Closures And Social Distancing, On The Mental Health Of School Age Children, Fatuma A. Hassan

Capstone Experience: Master of Public Health

Mental health is vital to the well-being of all individuals, especially children. COVID-19 unveiled a significant public health issue with poor mental health during the pandemic. There is limited literature about the mental health implications of COVID-19 policies for children and adolescents and preventive strategies for future pandemics. This comprehensive literature review seeks to further investigate the mental health impacts of school shutdowns and social distancing, which were nonpharmaceutical strategies, on school-aged children, 5-18 years old, and propose recommendations for public health officials to mitigate the mental health impacts for future pandemics. Additionally, the review aims to highlight the potential …