Digital Commons Network^™

Human Airway Mucociliary Tissue Cultures Chronically Exposed To E-Cigarette Vapors Exhibit Altered Cell Populations And Increased Secretion Of Immunomodulatory Cytokines, Vanessa Pizutelli, Vincent Manna, Shannon Dwyer, Salvatore Caradonna

Rowan-Virtua Research Day

Vape-pens or electronic cigarettes (e-cigarettes) are handheld battery powered devices that use a vape-liquid to produce a vapor that is inhaled by the user. The active ingredients in commercial vape-liquids are commonly nicotine, tetrahydrocannabinol or cannabidiol. A consequence of the rise in e-cigarette usage was the 2019 emergence of a vaping-induced respiratory disease denoted ‘e-cigarette or vaping use-associated lung injury’ (EVALI). One of the suspected causes of EVALI is Vitamin E Acetate (VEA), which was found to be a diluent in certain illicit tetrahydrocannabinol vape-pens, whereas nicotine is commonly diluted in equal parts propylene glycol and vegetable glycerin (PG:VG). The …

Exploring Risk Factors For Major Depressive Disorder For Female Patients Aged 18 Or Older Living In Ocean County, New Jersey, James Mack

Rowan-Virtua Research Day

Background: The incidence and prevalence of major depressive disorder has been increasing worldwide, in the United States of America, and on a local level. The population of Ocean County, New Jersey, a predominantly Caucasian, female, middle-aged population, may be at increased risk of developing major depressive disorder.

Purpose: To explore the social determinants of health and risk factors for major depressive disorder for female patients aged 18 or older living in Ocean County, New Jersey.

Methods: This literature review mainly used PubMed and Scopus for journal articles and utilized governmental databases for additional population data.

Results: Analyses conducted on social …

Telehealth Monitoring For Non-Hospitalized Covid-19 Positive Patients In A Rural Setting, Rebekah Leann French

Doctor of Nursing Practice Scholarly Projects

Purpose

This quality improvement project evaluates the efficacy of an outpatient COVID-19 telehealth monitoring program intended to increase access to care, decrease emergency room/urgent care visits, and hospital admissions among telehealth observed adult patients in a rural area while providing safe home monitoring during acute illness.

Rationale/Background

Prior to COVID-19 pandemic, healthcare systems within the United States encountered several challenges including healthcare inequality and decreased healthcare access, particularly in rural communities. These gaps became more apparent when a novel COVID-19 pandemic emerged straining healthcare systems in the United States and throughout the world. Challenges ranged from overwhelmed emergency room (ER) …

A Vlp-Based Vaccine Displaying Hbha And Mtp Antigens Of Mycobacterium Tuberculosis Induces Potentially Protective Immune Responses In M Tuberculosis H37ra Infected Mice, Juan Wang, Tao Xie, Inayat Ullah, Youjun Mi, Xiaoping Li, Yang Gong, Pu He, Yuqi Liu, Fei Li, Jixi Li, Zengjun Lu, Bingdong Zhu

Faculty, Staff and Student Publications

Heparin-binding hemagglutinin (HBHA) and M. tuberculosis pili (MTP) are important antigens on the surface of Mycobacterium tuberculosis. To display these antigens effectively, the fusion protein HBHA-MTP with a molecular weight of 20 kD (L20) was inserted into the receptor-binding hemagglutinin (HA) fragment of influenza virus and was expressed along with matrix protein M1 in Sf9 insect cells to generate influenza virus-like particles (LV20 in short). The results showed that the insertion of L20 into the envelope of the influenza virus did not affect the self-assembly and morphology of LV20 VLPs. The expression of L20 was successfully verified by transmission …

Synthetic Or Not: Implications Of Hormonal Birth Control On Women's Hormones And The Cortisol Stress Response, Madeline Perry '23

Senior Scholarly and Creative Symposium

Women’s bodies are the subject of decision-making and control, yet women’s lives are dismally ignored. The field of women’s health is highly understudied, and the demand for that adequate research must be granted to the women’s health field. This interdisciplinary research study investigated stress response differences between hormonal birth control users and non-users. Hormonal birth control (HBC) is one of the greatest technologies afforded to women and further research is necessary to ensure women are guaranteed bodily autonomy and women’s health education. Due to altered hormonal signaling, HBC has been linked to behavioral and decision-making differences in women. Building off …

An Overview Of Viruses And The Infamous Sars-Cov-2, Jake Sun

The Confluence

Background information on viruses is first presented which include topics like evolution, ecology, history, identification, structure, and application. The novel SARS-CoV-2, which causes COVID-19, pandemic originated in Wuhan, China in December 2019. Millions of people were infected with the virus in a short time period causing urgent concern worldwide. The purpose of this review is to provide a brief and general understanding of the SARS-CoV-2 to increase awareness and actions toward preventive measures. COVID-19 is a (+) ssRNA spherical enveloped virion that causes primarily respiratory illnesses. The S protein interacts with ACE-2 receptors on the host cell to gain entry …

The Myth Of Wellness: Deconstructing High, Contemporary Black Maternal Mortality Rates In The United States, Inaara Sultanali '23

Senior Scholarly and Creative Symposium

Maternal mortality is widely acknowledged as one of many general indicators of overall health of a population, of status of women in society, and of functioning of the health system (World Health Organization [WHO], 2001). The United States, among one of the most high-income countries, ranks near the top in maternal mortality and the trend is increasingly exacerbating (Association of American Medical Colleges [AAMC], 2022). There are stark racial disparities within the United States’ maternal mortality rates; Black women in the United States are three to four times more likely to die from a pregnancy-related death than their White counterparts …

Power, Pleasure, And Privilege: Defining Depauw’S Hookup Culture And Its Mental Health Implications, Reanna Stiehler '23

Senior Scholarly and Creative Symposium

Hookup culture is not primarily about sex, pleasure, connection, or freedom. Hookup culture is about power—how power is used, distributed, and desired. Previous work in hookup culture discusses a discourse of desire; however, the root and nature of this desire are unclear. I posit that hookup culture, as it currently exists, is strongly related to rape culture. In this thesis, I will explicate my anecdotal, qualitative, and quantitative evidence supporting this hypothesis.

This thesis provides an overview of what hookup culture is at a broad level. It then focuses more specifically on defining it at DePauw and considering the impact …

Association Of Prenatal Depression With New Cardiovascular Disease Within 24 Months Postpartum., Christina M Ackerman-Banks, Heather S Lipkind, Kristin Palmsten, Mariah Pfeiffer Rn, Mph, Catherine Gelsinger Rn, Katherine Ahrens Mph, Phd

Population Health

No abstract provided.

Spatial Transcriptomics Depict Ligand-Receptor Cross-Talk Heterogeneity At The Tumor-Stroma Interface In Long-Term Ovarian Cancer Survivors, Sammy Ferri-Borgogno, Ying Zhu, Jianting Sheng, Jared K Burks, Javier A Gomez, Kwong Kwok Wong, Stephen T C Wong, Samuel C Mok

Faculty, Staff and Student Publications

Advanced high-grade serous ovarian cancer (HGSC) is an aggressive disease that accounts for 70% of all ovarian cancer deaths. Nevertheless, 15% of patients diagnosed with advanced HGSC survive more than 10 years. The elucidation of predictive markers of these long-term survivors (LTS) could help identify therapeutic targets for the disease, and thus improve patient survival rates. To investigate the stromal heterogeneity of the tumor microenvironment (TME) in ovarian cancer, we used spatial transcriptomics to generate spatially resolved transcript profiles in treatment-naïve advanced HGSC from LTS and short-term survivors (STS) and determined the association between cancer-associated fibroblasts (CAF) heterogeneity and survival …

Higher Risk Of Short Term Covid-19 Vaccine Adverse Events In Myositis Patients With Autoimmune Comorbidities: Results From The Covad Study, Mrinalini Dey, Naveen R, Elena Nikiphorou, Parikshit Sen, Sreoshy Saha, James B Lilleker, Vishwesh Agarwal, Sinan Kardes, Jessica Day, Marcin Milchert, Mrudula Joshi, Tamer Gheita, Babur Salim, Tsvetelina Velikova, Abraham Edgar Gracia-Ramos, Ioannis Parodis, Albert Selva O'Callaghan, Minchul Kim, Tulika Chatterjee, Ai Lyn Tan, Ashima Makol, Arvind Nune, Lorenzo Cavagna, Miguel A Saavedra, Samuel Katsuyuki Shinjo, Nelly Ziade, Johannes Knitza, Masataka Kuwana, Oliver Distler, Bhupen Barman, Yogesh Preet Singh, Rajiv Ranjan, Avinash Jain, Sapan C Pandya, Rakesh Kumar Pilania, Aman Sharma, Manesh M Manoj, Vikas Gupta, Chengappa G Kavadichanda, Pradeepta Sekhar Patro, Sajal Ajmani, Sanat Phatak, Rudra Prosad Goswami, Abhra Chandra Chowdhury, Ashish Jacob Mathew, Padnamabha Shenoy, Ajay Asranna, Keerthi Talari Bommakanti, Anuj Shukla, Arunkumar R Pande, Kunal Chandwar, John D Pauling, Chris Wincup, Döndü Üsküdar Cansu, Erick Adrian Zamora Tehozol, Jorge Rojas Serrano, Ignacio García-De La Torre, Nicoletta Del Papa, Gianluca Sambataro, Atzeni Fabiola, Marcello Govoni, Simone Parisi, Elena Bartoloni Bocci, Gian Domenico Sebastiani, Enrico Fusaro, Marco Sebastiani, Luca Quartuccio, Franco Franceschini, Pier Paolo Sainaghi, Giovanni Orsolini, Rossella De Angelis, Maria Giovanna Danielli, Vincenzo Venerito, Lisa S Traboco, Leonardo Santos Hoff, Suryo Anggoro Kusumo Wibowo, Stylianos Tomaras, Daman Langguth, Vidya Limaye, Merrilee Needham, Nilesh Srivastav, Akira Yoshida, Ran Nakashima, Shinji Sato, Naoki Kimura, Yuko Kaneko, Jesús Loarce-Martos, Sergio Prieto-González, Albert Gil-Vila, Raquel Arànega Gonzalez, Hector Chinoy, Vikas Agarwal, Rohit Aggarwal, Latika Gupta

Faculty, Staff and Student Publications

No abstract provided.

Association Of Mitochondrial Dna Copy Number With Brain Mri Markers And Cognitive Function: A Meta-Analysis Of Community-Based Cohorts, Yuankai Zhang, Xue Liu, Kerri L Wiggins, Nuzulul Kurniansyah, Xiuqing Guo, Amanda L Rodrigue, Wei Zhao, Lisa R Yanek, Scott M Ratliff, Achilleas Pitsillides, Juan Sebastian Aguirre Patiño, Tamar Sofer, Dan E Arking, Thomas R Austin, Alexa S Beiser, John Blangero, Eric Boerwinkle, Jan Bressler, Joanne E Curran, Lifang Hou, Timothy M Hughes, Sharon L R Kardia, Lenore J Launer, Daniel Levy, Thomas H Mosley, Ilya M Nasrallah, Stephen S Rich, Jerome I Rotter, Sudha Seshadri, Wassim Tarraf, Kevin A González, Vasan Ramachandran, Kristine Yaffe, Paul A Nyquist, Bruce M Psaty, Charles S Decarli, Jennifer A Smith, David C Glahn, Hector M González, Joshua C Bis, Myriam Fornage, Susan R Heckbert, Annette L Fitzpatrick, Chunyu Liu, Claudia L Satizabal

Faculty, Staff and Student Publications

BACKGROUND AND OBJECTIVES: Previous studies suggest that lower mitochondrial DNA (mtDNA) copy number (CN) is associated with neurodegenerative diseases. However, whether mtDNA CN in whole blood is related to endophenotypes of Alzheimer disease (AD) and AD-related dementia (AD/ADRD) needs further investigation. We assessed the association of mtDNA CN with cognitive function and MRI measures in community-based samples of middle-aged to older adults.

METHODS: We included dementia-free participants from 9 diverse community-based cohorts with whole-genome sequencing in the Trans-Omics for Precision Medicine (TOPMed) program. Circulating mtDNA CN was estimated as twice the ratio of the average coverage of mtDNA to nuclear …

Qualitative Chemical Analysis Of Elf Bar E-Liquids And Their Effect On Phenotypic Characteristics Of Arabidopsis Thaliana, Genevieve Neuwirth

Graduate Dissertations and Theses

After their initial market introduction in 2003, the popularity and use of e-cigarettes have exponentially increased. There are three main components that have contributed to this: marketing, ease of access, and emerging flavors. The marketing industry uses claims that ecigarettes are a ‘safer’ and ‘healthier’ alternative to cigarettes as a way to entice previous smokers into using this product. With the increase in popularity, there is also an increase in demand, which has led to the creation of stores designed to target customers and sell e-cigarettes and similar products at convenient locations. Finally, the emerging flavors have enticed many nonsmokers …

An Investigation Of Resistance Training Behavior, Non-Specific Psychological Distress, And Perceived Barriers To Resistance Training In Self-Identifying Female Undergraduate Students, Jody Sobel

Master's Theses

The prevalence and severity of depression symptoms amongst college students, specifically female identifying undergraduate students, is worrisome. There is a great deal of research that suggests a relationship between exercise, specifically resistance training (RT), and mental health. That said, current literature suggests that many female identifying students are not engaging due to perceived barriers. This, perhaps because of the plethora of barriers one can perceive. The purpose of this study was multifold 1) to examine the prevalence and severity of non-specific psychological distress; 2) to determine if there were differences between Kessler 6 Non-Specific Psychological Distress Scale (K6) categories (i.e., …

Associations Between Technology Use, Responsive Feeding, And Child Temperament Among Prior Prenatal Intervention Participants, Alison K. Ventura, Chantelle N. Hart, Suzanne Phelan, Elissa Jelalian

Kinesiology and Public Health

Objectives: The primary objective was to examine associations between mothers’ television and mobile device (TV/MD) use and responsive feeding during an observed mother-toddler mealtime interaction. The secondary objective was to assess whether dimensions of child temperament were associated with mothers’ TV/MD use. Methods: Participants from a prenatal lifestyle intervention trial to prevent excess gestational weight gain among women with overweight and obesity (N 5 77) were observed during a dinnertime meal when their children were aged 19.4 6 0.9 months. Trained video coders used the Responsiveness to Child Feeding Cues Scale to rate child strength of early/subtle, positive active, and …

Social Support And Perceptions Of Covid-19-Related Emotional Impact On Mental Health Among Early Adolescents In Appalachia, Hannah M. Layman, Michael J. Mann, Megan L. Smith, Steven M. Kogan, Alfgeir L. Kristjansson

Public and Population Health Faculty Publications and Presentations

Background: Young people who experience higher levels of social support from their schools and families have been shown to be less likely to develop symptoms of negative mental health outcomes such as depression and anxiety.1–4 This raises questions concerning how young people's stress and psychological changes due to the COVID-19 pandemic as well as social support during this time have affected their overall mental health. The aim of this study was to assess the association between sources of parental- and school-level social support and youth perceptions of COVID-19-related emotional impact on mental health among early adolescent girls and boys in …

Women’S Pornography Use And Sexuality Education In U.S. Public Schools, Julie Fraumeni-Mcbride

Education (PhD) Dissertations

The relationship between sexuality education and self-reported pornography use is not well understood in the context of public policy and education. Little is known about women’s pornography use and the effects such exposure could have on female sexuality and well-being; therefore, this study sought to fill that gap. This study broadly examined the relationship between sexuality education in U.S. public schools and women’s pornography use to provide recommendations for future research and public policy. To do this, quantitative methods (i.e., Welch’s t tests for hypothesis testing and ANCOVAs for covariate elimination) were used in a sample of women who attended …

Adverse Birth Outcomes: Investigating The Role Of Nativity And Perceived Racial Discrimination Among Black Mothers Enrolled In Des Moines, Iowa Healthy Start., Kendria Kelly-Taylor

Electronic Theses and Dissertations

Birth outcomes for Black women in the United States (US) are disproportionately worse in comparison to non-Black women, even when controlling for potential confounders. Existing studies suggest foreign-born (FB) Black women present better birth outcomes in comparison to US-born (USB) Black women. Also, the longer FB Black women live in the US, the more their perinatal health advantage diminishes. Racial discrimination has been hypothesized as a potential reason for this decline. This dissertation investigates the relationship between nativity and adverse birth outcomes while also exploring how the reporting of racial discrimination impacts birth outcomes among FB and USB Black mothers …

Our Story, Our Song: Assessing And Addressing Black Women's Healthcare Experiences., Jason Deakings

Electronic Theses and Dissertations

Despite advancements in medicine and health sciences, health disparities and declining life expectancy persists among Black women in the United States. Researchers and non-traditional healthcare providers suggest alternative healing (e.g., music and Sister Circles) and research methodologies to achieve a culturally conscious, traumainformed, quality, and holistic care and practice. The intersecting identities and cultural responsibility of Black women highly influences the barriers and facilitators on the uptake of healthcare services. Utilizing a community engaged research approach, this qualitative study assessed the healthcare experiences, as well as the role of music in the lived and retold experiences of Black women navigating …

A Systematic Review Of Research On Treatment & Prevention Of The Neglected Tropical Disease Leishmaniasis, Aryn Akerberg

All Theses

Leishmaniasis is a life-threatening neglected tropical disease that is caused by the protozoa parasite, Leishmania. Over one million new human leishmaniasis cases occur each all over the world, affecting most the deeply impoverished regions of the world. The disease presents in three different forms: cutaneous leishmaniasis, mucocutaneous (mucosal) leishmaniasis, and visceral leishmaniasis. Symptoms can range from self-limiting lesion to more life-threatening conditions such as fever, kidney disease, and anemia. The Leishmania parasite is transmitted via the bite of the female phlebotomine sandfly and can infect many other mammals such as canines, rodents, bats, etc. The canine leishmaniasis epidemic is also …

Predictors And Barriers To Vaccination Among Older Syrian Refugees In Lebanon: A Cross-Sectional Analysis Of A Multi-Wave Longitudinal Study, Berthe Abi Zeid, Tanya El Khoury, Hala Ghattas Ph.D., Marwan F. Alawieh, Zeinab Ramadan, Sirine Anouti, Sawsan Abdulrahim, Stephen J. Mccall

Faculty Publications

Background:

Vaccination is important to prevent morbidity and mortality due to COVID-19 among older Syrian refugees. We aimed to elucidate the predictors of COVID-19 vaccine uptake among Syrian refugees aged 50 years or older in Lebanon and to understand their main reasons for not receiving the vaccine.

Methods:

This was a cross-sectional analysis of a five-wave longitudinal study, conducted through telephone interviews between Sept 22, 2020, and March 14, 2022, in Lebanon. For this analysis, data were extracted from wave 3 (Jan 21–April 23, 2021), which included a question on vaccine safety and on whether participants intended to receive the …

The Effects Of Mental Health And Burnout In Medicine In Relation To The Wilson Model Of Leadership, Kevin Beck

Senior Honors Projects

The purpose of this project is to determine the effects that burnout and poor mental health can have on the ability of health care professionals to effectively do their job and lead others in medicine. Burnout, as defined by Merriam Webster, is “the exhaustion of physical or emotional strength or motivation usually as a result of prolonged stress or frustration.” This is a self-reported quantitative study analyzing information acquired via a survey to determine if there is a relation to burnout and poor mental health in medicine and the ability to effectively lead others and complete work tasks and this …

Uri Athletics Fueling Station, Caitlin O'Leary

Senior Honors Projects

No abstract provided.

Childhood Sleep Health And Epigenetic Age Acceleration In Late Adolescence: Cross-Sectional And Longitudinal Analyses, David Balfour, Phillip E. Melton, Joanne A. Mcveigh, Rae-Chi Huang, Peter R. Eastwood, Sian Wanstall, Amy C. Reynolds, Sarah Cohen-Woods

Research outputs 2022 to 2026

Aim: Investigate if childhood measures of sleep health are associated with epigenetic age acceleration in late adolescence. Methods: Parent-reported sleep trajectories from age 5 to 17, self-reported sleep problems at age 17, and six measures of epigenetic age acceleration at age 17 were studied in 1192 young Australians from the Raine Study Gen2. Results: There was no evidence for a relationship between the parent-reported sleep trajectories and epigenetic age acceleration (p ≥ 0.17). There was a positive cross-sectional relationship between self-reported sleep problem score and intrinsic epigenetic age acceleration at age 17 (b = 0.14, p = 0.04), which was …

How Does Birth Control Impact Overall User Wellness: A Mixed-Methodology Approach Surveying How Physical, Mental, And Social Wellness Is Impacted By Use Of Birth Control, Ashley Beamon

Theses/Capstones/Creative Projects

The purpose of this study is to understand the ways in which birth control may impact wellness. By looking at physical activity, social wellness, experienced side effects, and a range of demographics, the goal is to better understand how the use of birth control may impact its user’s overall wellness. After gathering data in a two-week survey, I discovered that mood swings, weight gain, and depression were the top three reported side effects and Latina women reported irregular bleeding at a higher frequency than white women. Loneliness is impacted by birth control use; users were 30% more likely to report …

Healthcare Experiences By Race, Sex, And Weight Status In A Sample Of Low Wage Workers Before And During The Covid-19 Pandemic, Michael Ampofo

Honors Scholar Theses

There is longstanding evidence of racial, sex-based, weight-based, and socioeconomic status (SES) disparities in the quality of healthcare. These disparities can result from provider bias and discrimination in the healthcare system and can contribute to disparities in health outcomes. The emergence of the COVID-19 pandemic may have exacerbated differential treatment in healthcare due to the strain it placed on the healthcare system. The purpose of this study was to examine the impact of the COVID-19 pandemic on U.S. healthcare experiences among low SES non-Hispanic Black and non-Hispanic White patients. This secondary analysis utilized survey measures from 225 low-wage workers, ages …

Prevalence Of Sars-Cov-2 Antibodies By Rural-Urban Residential Status In Texas, Breanna Bailey Ellis

Dissertations and Theses (Open Access)

Understanding the health disparities associated with SARS-CoV-2 antibody status across Texas is essential. These differences can guide healthcare professionals and local public health officials to identify vulnerable populations needing COVID-19 prevention and treatment resources. This study aims to contribute to the literature by determining if rural and urban geographical locations are disproportionately impacted by SARS-CoV-2 infection and vaccination in the state of Texas. I utilized the Texas Coronavirus Antibody REsponse Survey (Texas CARES), a large ongoing prospective population-based survey among 5–90-year-olds from the Texas general population that began collecting seroprevalence data in October 2020 (1). Participants in the survey are …

Postpartum Depression In Jamaica: Exploring The Lived Experiences., Shakeyrah Elmore

Electronic Theses and Dissertations

The purpose of this study was to explore the lived experiences of Jamaican women with postpartum depression (PPD). It is estimated globally, postpartum depression impacts 10-20% of women. In Jamaica, rates exceed global averages, with 26-60% of women experiencing PPD. Untreated maternal depression poses a significant physical, social, and economic threat to Jamaican women, children, and society as a whole. This study affirms that maternal mental health and postpartum depression are global public health concerns. There are limited studies that have examined PPD in Jamaican women, especially qualitatively. This research study utilized a qualitative descriptive approach to examine PPD experiences …

Effect Of Temperature On The Microbiome Of A Laboratory-Reared Colony Of Haemaphysalis Longicornis Ticks, Brianna L. Mitchell

Honors Theses

Haemaphysalis longicornis ticks are invasive to the United States with potential to transmit several tick-borne pathogens that are native to the United States. Based on existing locations of H. longicornis in its native regions in Asia, as well as its invasive populations that are established in the United States, several geographic range prediction models have been produced to help understand future range expansion and distribution of this invasive tick in North America. Unfortunately, these models do not all agree and there is uncertainty associated with the potential geographic range expansion of H. longicornis ticks in North America. Climate can affect …

Perceptions Of Prenatal Care From Mississippi Mothers: The Role Of Race And Insurance Coverage, Brittney Clayborn

Honors Theses

Giving birth in America as an African American woman is a daunting and risky undertaking. African American women are three to four times more likely to die from giving birth and two times more likely to experience severe maternal morbidity than their White counterparts (Wang, Glazer, Sofaer, Balbierz, & Howell, 2020). The disparity seen in maternal health and mortality can partially be linked to other chronic health and medical factors; however, there are even disparities seen in those as well. Attention must be brought to the impact of race and socioeconomic status on the likelihood of survival after giving birth, …