Digital Commons Network^™

Children's Behavioral Traits And Risk Of Injury: Analyses From A Case-Control Study Of Agricultural Households, Kathleen F. Carlson, Susan G. Gerberich, Bruce H. Alexander, Ann S. Masten, Timothy R. Church, John M. Shutske, Andrew D. Ryan, Colleen M. Renier

United States Public Health Resources

Problem: Children on family agricultural operations have high risk of injury. The association between children's behavioral traits and their risk of injury is not well understood. Method: Data from the Regional Rural Injury Study-II were used to assess behavioral risk factors for injury to children ages six to <20 years. A total of 379 injury events (cases) and 1,562 randomly selected controls were identified. Adjusted odds ratios (OR) and 95% confidence intervals (CI), calculated using logistic regression, were used to estimate injury risk in reference to behavioral traits. Results: Injury risks were greater for children with high levels of depressive symptoms (OR=1.9, CI=1.0-3.7) and aggression (OR=1.6, CI=0.9-2.7), and low levels of careful/cautious behavior (OR=1.8, CI=1.1-2.9). Children with low levels of self-regulation had reduced risks (OR=0.4, CI=0.2-0.8). Discussion: Results suggest that children's behaviors affect their risk of agricultural injury. Additional research …

Carbon Tetrachloride-Induced Liver Damage In Asialoglycoprotein Receptor-Deficient Mice, Shana R. Dalton, Serene M.L. Lee, Rachel N. King, Amin A. Nanji, Kusum K. Kharbanda, Carol A. Casey, Benita L. Mcvicker

United States Public Health Resources

The asialoglycoprotein (ASGP) receptor is an abundant hepatocyte-specific receptor involved in receptor-mediated endocytosis. This receptor’s abundance and function is decreased by chronic ethanol administration prior to the appearance of pathology such as necrosis or inflammation. Hence, this study aimed to determine if ASGP receptor function is required to protect against liver injury by utilizing a knockout mouse model lacking functional ASGP receptor in the setting of carbon tetrachloride (CCl₄) hepatotoxicity. Briefly, ASGP receptor-deficient (RD) mice and wild-type (WT) mice were injected with 1 ml/kg body weight of CCl₄. In the subsequent week, mice were monitored for …

Nitric Oxide Inhibits Insulin-Degrading Enzyme Activity And Function Through S-Nitrosylation, Crystal M. Cordes, Robert G. Bennett, Gerri L. Siford, Frederick G. Hamel

United States Public Health Resources

Insulin-degrading enzyme (IDE) is responsible for the degradation of a number of hormones and peptides, including insulin and amyloid β (Aβ). Genetic studies have linked IDE to both type 2 diabetes and Alzheimer’s disease. Despite its potential importance in these diseases, relatively little is known about the factors that regulate the activity and function of IDE. Protein S-nitrosylation is now recognized as a redox-dependent, cGMP-independent signaling component that mediates a variety of actions of nitric oxide (NO). Here we describe a mechanism of inactivation of IDE by NO. NO donors decreased both insulin and Aβ degrading activities of IDE. Insulin-degrading …

The Overlooked Epidemic: Addressing Hiv Prevention And Treatment Among Men Who Have Sex With Men In Sub-Saharan Africa, National Aids Control Council Of Kenya, Population Council

HIV and AIDS

Globally, less than 1 out of 20 men who have sex with men (MSM) has access to HIV prevention and care. UNAIDS has estimated that at least 5 to 10 percent of all HIV infections globally occur through male-to-male sexual activity. In spite of the high risk of HIV infection and evidence of extensive sexual networks, national HIV programs in Africa have been slow to address MSM in prevention and treatment efforts. To address these issues, the Population Council and the National AIDS Control Council of Kenya convened a meeting on May 14–15, 2008. The goals of the meeting were …

Adolescent Girls In Urban Ethiopia: Vulnerability And Opportunity, Abebaw Ferede, Annabel Erulkar

Poverty, Gender, and Youth

In 2008, the Population Council undertook a survey of out-of-school, adolescent girls (aged 10 to 19) in slum areas of urban Ethiopia—a population that is highly vulnerable to HIV infection. The survey serves as a baseline for HIV prevention programs designed and implemented jointly by the Ministry of Youth and Sports, Regional Bureaus of Youth and Sports, and the Population Council. This study provided valuable direction for programmers interested in supporting adolescent girls, particularly early adolescent (10 to 14 years old) and out-of-school girls who are highly vulnerable and in need of dedicated attention. Special efforts are needed to support …

Analyzing Adherence To Prenatal Supplements: Does Pill Count Measure Up?, Kristie Elizabeth Appelgren

MUSC Theses and Dissertations

Background: Results of a trial of prenatal Vitamin D supplementation are analyzed for associations of pill count data with serum-based measures of adherence. Obiective: It is hypothesized that adherence as measured by pill count will have a significant association with serum-based measures of adherence. Design: The study from which the data for this analysis were derived is a large randomized, controlled, and double-blinded trial of vitamin D supplements in pregnant women. The women have been stratified by race and randomized into three groups, which receive a 400IU (control), 20001U, or 40001U dose of vitamin D[subscript 3] once daily. Women enter …

Violence Against Women Raises Risk Of Cervical Cancer, Ann L. Coker, Claudia Hopenhayn, Christopher P. Desimone, Heather M. Bush, Leslie Crofford

CRVAW Faculty Journal Articles

Background: An emerging literature suggests that violence against women (VAW), particularly sexual violence, may increase the risk of acquiring a sexually transmitted infection (STI) and, therefore, may be associated with cervical cancer development. The purpose of this cross-sectional analysis was to determine if women who had experienced violence had higher prevalence rates of invasive cervical cancer.

Methods: Women aged 18–88 who joined the Kentucky Women’s Health Registry (2006–2007) and completed a questionnaire were included in the sample. Multivariate logistic regression analyses were used to adjust odds ratio (OR) for confounders (e.g., age, education, current marital status, lifetime illegal drug use, …

The Effects Of Aerosolized Brevetoxin Exposure On The Human Respiratory System, Katie M. Spaulding

International Journal of Global Health and Health Disparities

While much information has been collected about the effects of brevetoxin ingestion in contaminated seafood, there has been very little research conducted and little is known about the effects of these toxins when inhaled in aerosols (Backer et al., 2003). The effects of brevetoxins are of great public health concern because not only are harmful algal blooms increasing in frequency and duration of occurrence, they are also expanding their area of distribution (Sellner et al., 2003; Kirkpatrick, 2004). Since a significant proportion of the world's population live within 75 miles of an ocean coast and this density of human coastal …

Examining Conversational Constraints In Vietnamese Patient-Doctor Communication: A Case Study, Kimberly Tran

XULAneXUS

The purpose of this study was to determine the use of conversational constraints among older members of the New Orleans Vietnamese community within the primary healthcare context. A purposive sample of seven Vietnamese male and five Vietnamese female immigrants between the ages of 47 and 80 was interviewed. Conversational constraints were evident in the responses relating to communication with physicians. The respondents emphasized relational conversational constraints such as minimal imposition on the physician’s autonomy, prevention of hurting the physician’s feelings, and prevention of negative evaluation by the physician. Conversely, task-oriented conversational constraints such as concern for clarity and effectiveness were …

Cellular Telephones And Cancer: Is There A Connection?, James Bolton

International Journal of Global Health and Health Disparities

Cellular telephones have been accused of causing brain tumors for years, but none of the studies that have been published have proven there is a link. The tumors that have been researched include parotid gland tumors, acoustic neuromas, and acoustic gliomas, to name a few. Wireless cellular phone usage has been increasing over the past few years, and some European countries are said to have a penetration rate of over 100%, "which is to say there are more subscribers than inhabitants"². Wireless technology emits electromagnetic energy (AKA microwave radiation or radiofrequency radiation), and sources include not only cellular …

Participation And Determinants Of Physical Activity Amongst Irish 3rd Level Students., Jonathan Lerner

Theses

Currently, there is a dearth of research investigating physical activity patterns among Irish third level young adults (17-22 year olds). Both national and international research report that levels of physical activity decline in adolescence, this trend being most pronounced among females. Various biological, psychological, social, and environmental determinants have been found to influence physical activity; however, specific factors associated with the decline in activity during adolescence remain largely unknown. This research study examines participation and determinants of physical activity among Irish third level students.

A “National questionnaire” was administered to a sample of 532 students from Health Education Authority (HEA) …

The Cultural Production Of Health Inequalities: A Cross-Sectional, Multilevel Examination Of 52 Countries, Carol L. Mansyur, Benjamin C. Amick Iii, Ronald B. Harrist, Luisa Franzini, Robert E. Roberts

Community & Environmental Health Faculty Publications

In a 2001 report, the U.S. National Institutes of Health called for more integration of the social sciences into health-related research, including research guided by theories and methods that take social and cultural systems into consideration. Based on a theoretical framework that integrates Hofstede's cultural dimensions with sociological theory, the authors used multilevel modeling to explore the association of culture with structural inequality and health disparities. Their results support the idea that cultural dimensions and social structure, along with economic development, may account for much of the cross-national variation in the distribution of health inequalities. Sensitivity tests also suggest that …

Socioeconomic Disparity In Healthcare-Seeking Behavior Among Chinese Women With Genitourinary Symptoms, Qi Zhang, Diane Lauderdale, Shanshan Mou, William I. Parish, Edward O. Laumann, John Schneider

Community & Environmental Health Faculty Publications

Background: Sexually transmitted infections (STIs) are of growing concern in China. Understanding the relationship between socioeconomic status (SES) and healthcare-seeking (HCS) behavior will help design effective policies to contain the epidemic of STIs across SES.

Methods: We used the Chinese Health and Family Life Survey, a nationally representative survey of 3813 adults from 48 Chinese cities and counties during 1999-2000. We studied the 730 women with at least one genito-urinary (GU) symptom. HCS was measured by whether respondents visited a hospital or an unrecognized clinic, self-treatment, or doing nothing. Formal treatment was defined as visiting a hospital. SES was measured …

Handbook On Sensitive Practice For Health Care Practitioners: Lessons From Adult Survivors Of Childhood Sexual Abuse, Candice L. Schachter, Carol A. Stalker, Eli Teram, Gerri C. Lasiuk, Alanna Danilkewich

Lyle S. Hallman Social Work Faculty Publications

This handbook is the culmination of a multiphase, multidisciplinary research project that used grounded theory and participatory action research to illuminate ways that healthcare providers can work sensitively (in a trauma-informed way) with adult survivors of childhood sexual abuse.

The research identified nine Principles of Sensitive Practice: respect, rapport, taking time, sharing information and control, respecting boundaries, fostering mutual learning, understanding non-linear healing and demonstrating an understanding of trauma to patients. Specific guidelines were developed for a wide variety of issues pertinent to clinical practice such as, removal of clothing, touch, responding to disclosures of abuse, managing triggers among others. …

Ua3/1/2/1 President's Office-Cherry - Correspondence - General, Wku Archives

WKU Archives Collection Inventories

General correspondence regarding Western Kentucky University. Incoming letters are mainly addressed to Henry Hardin Cherry. Responses are made by Cherry and occasionally by faculty and staff. The president's secretary Mattie McLean is the writer for some of the letters signed by Cherry.

Some of Cherry's personal papers are also found in this series most notably those pertaining to his political aspirations and two candidacies for the Kentucky governorship. Copies of outgoing correspondence begin to appear in Box 1, Folder 50.

Perception Of Dietary Change And Attitudes Towards The Irish Diet Among Non-Nationals In Ireland., Qianling Zhou, Phensiri Asawasirisap, John Kearney

Conference Papers

Rationale & Objectives: Cross-cultural attitudes to diet differ significantly. This study examined attitudes towards the Irish diet and their perceived dietary change among a random sample of non-nationals living in Ireland. Materials & Methods: A self-administered cross-sectional survey was distributed to a randomly selected sample of English language students in Dublin. Results & Findings: 473 students from four geographical regions (Asia, Africa, South & Central American, and Europe) (response rate: 84%) completed the survey. Marked cultural differences between geographical regions were found with South & Central Americans being the most likely to indicate a decrease in fruit and vegetable intakes …

Children's Exposure To Lead And Nickel In Esperance - A Case Study, Matthew Tristan Winters

Theses : Honours

This is a cross-sectional study of lead and nickel exposure of children aged 2-12 years living at varying distances from a point source of pollution in Esperance. Esperance was an ideal case study location because of previous environmental contamination with lead and nickel above background levels. Non-invasive biological samples of hair, toenails and urine were collected from participating children, and environmental samples, including house dust, soil and drinking water were also sampled from each participant household. Exposure was assessed by measuring the concentration of metals found in the biological samples, and determining their relationships with the environmental samples from each …

Establishing Public Health Security In A Postwar Iraq: Constitutional Obstacles And Lessons For Other Federalizing States, David P. Fidler, Kumanan Wilson, Christopher W. Mcdougall, Harvey Lazar

Articles by Maurer Faculty

The public health consequences of the conflict in Iraq will likely continue after the violence has subsided. Reestablishing public health security will require large investments in infrastructure and the creation of effective systems of governance. On the question of governance, the allocation of powers in the new constitution of Iraq is critical. Given the ease with which public health threats cross borders, the constitution needs to grant to the federal government the legal authority to manage such threats and simultaneously meet international requirements. Unfortunately, the draft constitution does not accomplish this objective. If politically possible, the constitution should be amended …

Infected Justice : The Impact Of Hiv/Aids On The Police In Anglo-Phone Sub-Saharan Africa, Nathan Carl Meehan

Legacy Theses & Dissertations (2009 - 2024)

Sub-Saharan Africa is an epicenter of the HIV/AIDS epidemic. This disease is affecting nearly every aspect of society in this region. This disease destroys individuals, strains family structures, weakens economies, burdens health systems, and can destabilize entire countries. The police are also being affected by HIV/AIDS. The way in which this disease impacts police organizations in sub-Saharan Africa is understudied. This project sought to estimate the HIV/AIDS impacts on police organizations in Anglo-phone sub-Sahara by utilizing the available literature on how HIV/AIDS affects military, civil service, healthcare, and education organizations in these same countries. It also attempts to identify the …

Harm Reduction In Outpatient Drug-Free Substance Abuse Treatment Settings, Michael Eversman

Legacy Theses & Dissertations (2009 - 2024)

In the United States, drug-free substance abuse treatment programs generally operate under an abstinence-only, disease model based service orientation. Citing several reasons, critics suggest disease model approaches hinder client utilization and retention within such services. The framework of harm reduction offers an alternative approach to substance abuse treatment services and may have potential for improving utilization and retention outcomes. Yet little is known about how harm reduction is perceived by practitioners in drug-free substance abuse treatment settings, and the circumstances in which harm reduction may or may not be accepted. In addition, despite a body of narrative literature suggesting harm …

Identification Of B-Cell Epitopes On Domain 4 Of Anthrax Protective Antigen, Cassandra D. Kelly-Cirino

Legacy Theses & Dissertations (2009 - 2024)

Protective Antigen (PA) is the receptor binding subunit common to both Lethal (LT) and Edema (ET) toxins, which contribute to the mortality associated with Bacillus anthracis infection. While recombinant PA (rPA) is likely to be an important constituent of second generation anthrax vaccines, evaluating the effectiveness of candidate vaccines is currently difficult, because the specific B cell epitopes involved in toxin neutralization have not been completely defined. The only well characterized antibody, 14B7, has been shown to disrupt the association of PA with the anthrax toxin receptors (ATR) by binding to domain 4 of PA. I hypothesized that other domain …

Biomonitoring For Exposure To Trace Elements In Utero : Analysis Of The Human Placenta, Pamela Catherine Kruger

Legacy Theses & Dissertations (2009 - 2024)

The placenta forms in eutherian mammals, and is responsible for the nutrition of the developing fetus. However, maternal exposure to environmental pollutants both before and during pregnancy may result in the passage of toxins through the placental barrier and into fetal tissues. The placenta is the only organ derived from both maternal and fetal tissues, and establishes a link between the fetus and the environmental exposures of the mother. The analysis of placentae for the presence of environmental pollutants offers the possibility of exposure measurements in both the mother and the developing fetus. Specifically, trace element determination in human placentae …

It's All One Curriculum: Activities For A Unified Approach To Sexuality, Gender, Hiv, And Human Rights Education, International Sexuality And Hiv Curriculum Working Group, Nicole Haberland, Deborah Rogow

Poverty, Gender, and Youth

Education on sexuality and HIV can help adolescents develop the capacity for healthy, respectful relationships and protect themselves from unwanted and unsafe sex, unintended pregnancy, and sexually transmitted infections. A 2015 Population Council study found that sexuality and HIV education programs that address gender and power in intimate relationships are five times more likely to be effective than programs that do not. However, most curricula still do not address these issues. It’s All One Curriculum provides a rationale, content, and sample activities for placing gender and rights at the center of sexuality and HIV curricula—both as stand-alone modules and integrated …

Attenuation Of Doxorubicin-Induced Cardiac Injury By Mitochondrial Glutaredoxin 2, Nicole M. Diotte, Ye Xiong, Jinping Gao, Balvin H.L. Chua, Ye-Shih Ho

United States Public Health Resources

While the cardiotoxicity of doxorubicin (DOX) is known to be partly mediated through the generation of reactive oxygen species (ROS), the biochemical mechanisms by which ROS damage cardiomyocytes remain to be determined. This study investigates whether S-glutathionylation of mitochondrial proteins plays a role in DOX-induced myocardial injury using a line of transgenic mice expressing the human mitochondrial glutaredoxin 2 (Glrx2), a thiotransferase catalyzing the reduction as well as formation of protein–glutathione mixed disulfides, in cardiomyocytes. The total glutaredoxin (Glrx) activity was increased by 76% and 53 fold in homogenates of whole heart and isolated heart mitochondria of Glrx2 transgenic mice, …

Animal Helminths In Human Archaeological Remains: A Review Of Zoonoses In The Past, Luciana Sianto, Marcia Chame, Cassius S. P. Silva, Marcelo L. C. Gonçalves, Karl Reinhard, Martín Horacio Fugassa, Adauto Araújo

Karl Reinhard Publications

The authors present a review of records of intestinal parasitic helminths from animals in human archaeological remains, reported since the emergence of paleopathological studies. The objective was to relate paleoparasitological findings to geographic, biotic, and abiotic factors from the environment in which the prehistoric populations lived, and understand some aspects related to the process of human dispersion and biological and cultural evolution. Modification of eating habits and the incorporation of new cultural practices are analyzed from the perspective of zoonoses from prehistory to the present day, especially in Brazilian indigenous populations. Three tables identifying the helminths, their natural hosts, dates, …

Lao Health And Adjustment In Southern New England Three Decades After The Secret War, Patrick F. Clarkin

Institute for Asian American Studies Publications

This study explored Lao life histories, health, and social adjustment in the southern New England states of Rhode Island and Connecticut. In addition, it sought to examine whether there was a correlation between war experiences early in life and health in adulthood, a finding reported in previous research on the Hmong, another ethnic group from Laos. Overall, 99 Lao adults born in Laos or Thailand (mean age 43.5 +/- 10.8 years) completed orally administered questionnaires and were measured for blood pressure and various anthropometric markers. Lao in this sample appeared to have higher than average educational back grounds in Laos, …

Ritonavir Blocks Akt Signaling, Activates Apoptosis And Inhibits Migration And Invasion In Ovarian Cancer Cells, Sanjeev Kumar, Christopher S. Bryant, Sreedhar Chamala, Aamer Qazi, Shelly Seward, Jagannath Pal, Christopher P. Steffes, Donald W. Weaver, Robert Morris, John M. Malone, Masood A. Shammas, Madhu Prasad, Ramesh B. Batchu

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Ovarian cancer is the leading cause of mortality from gynecological malignancies, often undetectable in early stages. The difficulty of detecting the disease in its early stages and the propensity of ovarian cancer cells to develop resistance to known chemotherapeutic treatments dramatically decreases the 5-year survival rate. Chemotherapy with paclitaxel after surgery increases median survival only by 2 to 3 years in stage IV disease highlights the need for more effective drugs. The human immunodeficiency virus (HIV) infection is characterized by increased risk of several solid tumors due to its inherent nature of weakening of immune system. Recent observations …

Validation Of Inverse Seasonal Peak Mortality In Medieval Plagues, Including The Black Death, In Comparison To Modern Yersinia Pestis-Variant Diseases, Mark R. Welford, Brian H. Bossak

Earth, Environment & Sustainability: Faculty Publications

Background: Recent studies have noted myriad qualitative and quantitative inconsistencies between the medieval Black Death (and subsequent ‘‘plagues’’) and modern empirical Y. pestis plague data, most of which is derived from the Indian and Chinese plague outbreaks of A.D. 1900615 years. Previous works have noted apparent differences in seasonal mortality peaks during Black Death outbreaks versus peaks of bubonic and pneumonic plagues attributed to Y. pestis infection, but have not provided spatiotemporal statistical support. Our objective here was to validate individual observations of this seasonal discrepancy in peak mortality between historical epidemics and modern empirical data.

Methodology/Principal Findings: …

Cultural Competence In Long Term Care : A Qualitative Phenomenological Study Of Nursing Home Administrators' Knowledge And Perception Of Cultural Competence, Sashai A. Green

HIM 1990-2015

This qualitative phenomenological study examined central Florida's nursing home administrators' knowledge and perception of cultural competence and how they perceive that their knowledge and perceptions impact residents, families, and healthcare. The theoretical framework for this study was explained through Campinha-Bacote's interdisciplinary model of The Process of Cultural Competence in the Delivery of Healthcare Services. The theoretical framework was used to guide research questions, and individual interview questions to obtain nursing home administrator's knowledge and perception of cultural competence. The study explored the level of cultural competence reported by nursing home administrators, their individual perception of cultural competence, their degree of …

Relationship Between The Mind Map Learning Strategy And Crtitical Thinking In Medical Students, Anthony V. D'Antoni

Seton Hall University Dissertations and Theses (ETDs)

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