Digital Commons Network^™

Male Circumcision Significantly Reduces Prevalence And Load Of Genital Anaerobic Bacteria, Cindy M. Liu, Bruce A. Hungate, Aaron A.R. Tobian, David Serwadda, Jacques Ravel, Richard Lester, Godfrey Kigozi, Maliha Aziz, Ronald M. Galiwango, Fred Nalugoda, Tania L. Contente-Cuomo, Maria J. Wawer, Paul Keim, Ronald H. Gray, Lance B. Price

Environmental and Occupational Health Faculty Publications

Male circumcision reduces female-to-male HIV transmission. Hypothesized mechanisms for this protective effect include decreased HIV target cell recruitment and activation due to changes in the penis microbiome. We compared the coronal sulcus microbiota of men from a group of uncircumcised controls (n= 77) and from a circumcised intervention group (n = 79) at enrollment and year 1 follow-up in a randomized circumcision trial in Rakai, Uganda. We characterized microbiota using16S rRNA gene-based quantitative PCR (qPCR) and pyrosequencing, log response ratio (LRR), Bayesian classification, nonmetric multidimensional scaling (nMDS), and permutational multivariate analysis of variance (PerMANOVA). At baseline, men …

Pilot Study Of Cyp2b6 Genetic Variation To Explore The Contribution Of Nitrosamine Activation To Lung Carcinogenesis, Catherine Wassenaar, Qiong Dong, Christopher Amos, Margaret Spitz, Rachel F. Tyndale

Dartmouth Scholarship

We explored the contribution of nitrosamine metabolism to lung cancer in a pilot investigation of genetic variation in CYP2B6, a high-affinity enzymatic activator of tobacco-specific nitrosamines with a negligible role in nicotine metabolism. Previously we found that variation in CYP2A6 and CHRNA5-CHRNA3-CHRNB4 combined to increase lung cancer risk in a case-control study in European American ever-smokers (n = 860). However, these genes are involved in the pharmacology of both nicotine, through which they alter smoking behaviours, and carcinogenic nitrosamines. Herein, we separated participants by CYP2B6 genotype into a high- vs. low-risk group (*1/*1 + *1/*6 vs. *6/*6). Odds ratios estimated …

A Study Of Coverage Optimized Planning Incorporating Models Of Geometric Uncertainties For Prostate Cancer, Huijun Xu

Theses and Dissertations

A fundamental challenge in the treatment planning process of multi-fractional external-beam radiation therapy (EBRT) is the tradeoff between tumor control and normal tissue sparing in the presence of geometric uncertainties (GUs). To accommodate GUs, the conventional way is to use an empirical planning treatment volume (PTV) margin on the treatment target. However, it is difficult to determine a near-optimal PTV margin to ensure specified target coverage with as much normal tissue protection as achievable. Coverage optimized planning (COP) avoids this problem by optimizing dose in possible virtual treatment courses with GU models directly incorporated. A near-optimal dosimetric margin generated by …

Counterclaim? Not A Real Fix To Prevent Patient Use Code Abuse, Ge Lei J.D.

North Carolina Central University Science & Intellectual Property Law Review

No abstract provided.

Optimization Of Radiation Therapy In Time-Dependent Anatomy, W. Tyler Watkins

Theses and Dissertations

The objective of this dissertation is to develop treatment planning techniques that have the potential to improve radiation therapy of time-dependent (4D) anatomy. Specifically, this study examines dose estimation, dose evaluation, and decision making in the context of optimizing lung cancer radiation therapy. Two methods of dose estimation are compared in patients with locally advanced and early stage lung cancer: dose computed on a single image (3D-dose) and deformably registered, accumulated dose (or 4D-dose). The results indicate that differences between 3D- and 4D- dose are not significant in organs at risk (OARs), however, 4D-dose to a moving lung cancer target …

A Climate For Swelling: The Social & Biological Impacts Of Lymphatic Filariasis On Males & Females In Developing Countries, Arezoo Nazari '13

Honor Scholar Theses

Neglected tropical diseases (NTD) impair physical and cognitive development. This impairment makes it difficult to earn a living, restricts quality of life, and limits productivity in the work force. As a result, neglected tropical diseases trap the poor in a cycle of disease and poverty. Lymphatic filariasis (LF), also known as elephantiasis, is an NTD. It starts when microscopic, thread-like parasitic worms (Wuchereria bancrofti, Brugia timori, and Brugia malayi) are transmitted by mosquitoes. These worms infect and block the lymph nodes in the body, causing edema. Blockage in the lymphatic system and build-up of tissue and blood flow often occur …

Early Prenatal Food Supplementation Ameliorates Thenegative Association Of Maternal Stress With Birth Size In A Randomised Trial, Amy L. Frith, Ruchira T. Naved, Lars Ake Persson, Edward A. Frongillo Jr.

Faculty Publications

Low birthweight increases the risk of infant mortality, morbidity and poor development. Maternal nutrition and stress influence birth size, but their combined effect is not known.We hypothesised that an early-invitation time to start a prenatal food supplementation programme could reduce the negative influence of prenatal maternal stress on birth size, and that effect would differ by infant sex. A cohort of 1041 pregnant women, who had delivered an infant, June 2003–March 2004, was sampled from among 3267 in the randomised controlled trial, Maternal Infant Nutritional Interventions Matlab, conducted in Matlab, Bangladesh. At 8 weeks gestation, women were randomly assigned an …

Correlates And Predictors Of Risky Sexual Partnering, Jennifer Nield

Theses and Dissertations

Introduction: Sexually Transmitted Diseases, including HIV/AIDS, continue to be a major burden in the United States. Sexual partnering behaviors contribute to the spread of STDs. Sexual concurrency has been shown to exponentially increase STD prevalence in populations. Serial monogamy with short periods between sexual partners also introduces risk. Methods: We identified sexually active men and women from the 2006-2010 National Survey of Family Growth (NSFG) and used sub sets for each particular study. Sexual partnering was defined as being concurrent, serially monogamous or monogamous in the previous year. Polytomous logistic regression models were developed to evaluate the associations between age …

Occupational Exposure To Ultraviolet Radiation And Risk Of Non-Melanoma Skin Cancer In A Multinational European Study, Simona Surdu, Edward F. Fitzgerald, Michael S. Bloom, Francis P. Boscoe, David Orlo Carpenter, Richard F. Haase, Eugen S. Gurzau, Peter Rudnai, Kvetoslava Koppova, Joelle Fevotte, Giovanni Leonardi, Marie Vahter, Walter Goessler, Rajiv Kumar, Tony Fletcher

Epidemiology & Biostatistics Faculty Scholarship

Background: Studies suggest that ambient sunlight plays an important role in the pathogenesis of non-melanoma skin cancers (NMSC). However, there is ongoing controversy regarding the relevance of occupational exposure to natural and artificial ultraviolet radiation (UV) radiation.

Objectives: We investigated potential associations between natural and artificial UV radiation exposure at work with NMSC in a case-control study conducted in Hungary, Romania, and Slovakia. Methods: Occupational exposures were classified by expert assessment for 527 controls and 618 NMSC cases (515 basal cell carcinoma, BCC). Covariate information was collected via interview and multiple logistic regression models were used to assess associations between …

The Impact Of The Chinese Rural Healthcare System On Infectious Disease: A Study Of The History And Reform Of Chinese Healthcare, And The Global Implications Of Infectious Disease Control In China, John Barbadoro

Independent Study Project (ISP) Collection

China’s healthcare system has gone through significant changes in the 20^th and 21^st centuries. These changes have mirrored not only the political focus of the time, but also the social issues facing China. The NRCMCS for rural residents is a cheap annual fee that covers a percentage of medical costs. There are two urban equivalents, the BMIUE and BMIUR for urban employees through their job, and residency respectively. Despite the focus on cheaper healthcare for rural residents, the problems of income inequality and mistrust in the medical system are major problems that affect the health of this large …

Adding Injustice To Injury - Health Perceptions, Plurality, And Power In The Ongoing Bhopal Disaster, Ruth Markwardt

Independent Study Project (ISP) Collection

Standards of health, human rights, and development are typically defined and dictated by policymakers instead of the populations directly affected by so-called development efforts. This paper seeks to contextualize global development efforts by highlighting specific local realities among the community of Bhopal Disaster survivors in Madhya Pradesh, India. As the site of the world’s largest industrial disaster, a disaster which is not over but ongoing, Bhopal represents an important population to highlight as the disaster continues. The Political Ecology of Health model was used to highlight political and environmental influences on community health. Within Political Ecology, this study takes a …

Pregnant With Parasites: Assessing Parasitic Infections In Pregnant Women Of The Kwale District, Christina Hopkins Hopkins

Independent Study Project (ISP) Collection

Parasitic infections such as malaria and intestinal worms plague many tropical and sub-tropical regions. The Kwale district of Kenya is among one of these regions and provides many circumstances that make these parasites endemic to the area. Pregnant women are part of the major groups affected by parasites. Although clinical professionals are making great attempts at reducing the chances for parasitic infections in these women, there are still some factors that are out of their control. Most women do not receive their drinking water from a secure water source and a majority of the women did not have the financial …

Transitioning Veterans Collaborative, Suzanne Arnott, Kiara Baginski, Geoff Ball, Elizabeth Buchanan, Jay Choi, Courtney Gieber, Jackie Lussier, Nigel Madden, Satya Piccioni-Grenna, Nellie Trenga-Schein, Paul Tschudi, Heidi Wolff

ISCOPES Posters and Presentations

No abstract provided.

The Influences Of Climatic And Socioeconomic Variables On Cholera Incidence In India During The Seventh Pandemic, 1961-2008, Kathleen M. Henschel

Master of Public Health Program Student Publications

Background: Cholera outbreaks result in significant morbidity worldwide. Transmission of the disease may be influenced by weather fluctuations, such as El Niño-Southern Oscillation (ENSO) and excessive rainfall, and socioeconomic status (SES), including income and education. El Niño events may influence many aspects of the climate, including the amount of rainfall occurring in a given year and surface water temperature. This study aimed to assess the influences of extreme weather and SES factors on cholera incidence in India during the seventh cholera pandemic (1961-2008).

Methods: Data for all variables were obtained for 1961-2008. Indian population estimates and cholera incidence (IR) were …

Performance And Measurement Of A Community-Based Distribution Model Of Family Planning Services In Pakistan, Syed Khurram Azmat, Shirin Ahmed, Waqas Hameed, Mohsina Bilgrami, Ayesha Khan, Adnan Ahmad Khan, Ghulam Mustafa

Community Health Sciences

Introduction: Community-based distribution (CBD) has been successfully applied to family planning (FP) services worldwide. It forms the basis for the large lady health worker (LHW) programme in Pakistan which serves a limited number of women with contraception services. Thus, the concept has seen limited application in Pakistan. We present the outcomes of a CBD model that was implemented in 49 districts across Pakistan by a non-government organization (NGO).
Methods: The Marie Stopes Society (MSS) developed a CBD model around its fixed centres and reached around half a million married women of reproductive age (MWRA) with services. The services provided included …

Fertile Lands And Bodies: Connecting The Green Revolution, Pesticides, And Women’S Reproductive Health, Sarah M.K. Cycon

Pitzer Senior Theses

Environmentalists, social scientists, and economists have long critiqued the enduring impacts of the Green Revolution’s diffusion of agricultural technologies throughout the Global South. However, largely missing from the myriad analyses is the relationship between those technologies, namely pesticides, and health outcomes. This thesis explores the social and biological mechanisms through which excessive pesticide use culminated into adverse reproductive health outcomes for rural women in the Global South. Drawing together the history of the Green Revolution’s use of DDT, its social and economic impacts, and the biology of pesticide contamination in women’s bodies exposes how the Green Revolution situated women in …

Evaluating The Efficacy Of A Childhood Lead Poisoning Risk Model As An Accurate Predictor Of Lead Exposure, Christopher R. Rustin

College of Graduate Studies: Theses & Dissertations

Lead poisoning is a significant public health problem with paint from old housing exposing thousands of children and leading to negative health and social outcomes. Identifying the highest risk children exposed to lead is important to public health agencies. The purpose of this study was to evaluate and assess the efficacy of a new geographically-based lead risk model that when combined with a child's physical address, predicts the extent of a child's risk of lead poisoning on a numeric risk scale. This model is unique because it calculates risk at the address level from parcel attributes of age and type …

Femininity, Dependency, And Patriarchy: The Marginalization Of Women With Japanese Encephalitis And Neurological Sequelae In The Northern Terai Region Of Uttar Pradesh, Katherine Ehrenreich

Independent Study Project (ISP) Collection

The present study seeks to determine how girls and women who have suffered from neurological sequelae after a Japanese encephalitis (JE) infection are marginalized in the Northern Terai region of Uttar Pradesh, India. Societal and familial values were studied in comparison to behaviors towards a neurologically disabled girl after a JE infection in order to determine how women infected with JE are excluded from cultural practices and norms. The 4 study was conducted in the Northern Terai region of Uttar Pradesh in the districts of Bahraich and Shrawasti under the guidance of DEHAT and Dr. Jitendra Chaturvedi. Semi-structured interviewing was …

Daily Walking And Life Expectancy Of Elderly People In The Iowa 65+ Rural Health Study, Hani M. Samawi

Biostatistics: Faculty Publications

The purpose of this paper is to investigate the hypothesis that outdoor daily walking, as an exercise, has an effect on the rate of mortality among those elderly people in the Iowa 65+ Rural Health Study (RHS). RHS is a prospective longitudinal cohort study of 8 years follow-up from 1981 to 1989. It consists of a random sample of 3,673 individuals (1,420 men and 2,253 women) aged 65 or older living in Washington and Iowa counties of the State of Iowa. Our analysis was conducted only on those non-institutional individuals who could without any help walk across a small room; …

Vitamin D Supplementation Practices During Pregnancy And Infancy Among A Sample Of Muslim Women In Ireland And Saudi Arabia, Imann Khadrawi

Masters

Vitamin D is a steroid hormone, a group of fat-soluble pro-hormones, which encourages the absorption and metabolism of calcium and phosphorous. The requirement for the nutrient is high at particular stages of the lifecycle especially during pregnancy and infancy. Severe vitamin D deficiency during pregnancy may increase the risk of developing preeclampsia and gestational diabetes in pregnancy and rickets in the child. While vitamin D supplementation has been a policy recommendation in Ireland since 2007, at the time of this study, it was not a policy recommendation in Saudi Arabia. The present quantitative cross-sectional survey was conducted to determine the …

Fa’Amatala Lau Tala: Samoan Pregnancy And Childbirth Narratives, Elsa Kendall

Independent Study Project (ISP) Collection

Pregnancy is, for each individual woman, situated in a particular historical, social, and cultural understanding of her own body; the experience cannot be divorced from these components that inform what is deemed unhealthy or inappropriate. Most social research regarding pregnancy and childbirth focuses on economic and political implications. This study explored personal narratives of Samoan women’s experience with pregnancy and childbirth to shed light on cultural aspects of events. Seven women were interviewed as key informants using informal, unstructured interviews to better understand these topics, and are presented as a compilation of stories of the most intimate parts of their …

Sweet Freedom: Smokers’ Rights & The Rebranding Of Philip Morris, Amy Dipierro

Annual Undergraduate Conference on Health and Society

This paper discusses how Philip Morris invoked strong American values to defend its own corporate speech as well as “smoker’s rights.” In particular, it examines Philip Morris Company’s Bill of Rights advertising campaign of the early 1990s, especially focusing on an advertisement featuring Everett Alvarez, a prisoner of war during Vietnam. This strategy reveals how Philip Morris was able to manipulate the public conversation about smoking from one about health and disease to one about human rights and freedoms.

Pit Latrines And Their Impacts On Groundwater Quality: A Systematic Review, Jay P. Graham, Matthew L. Polizzotto

Environmental and Occupational Health Faculty Publications

Background: Pit latrines are one of the most common human excreta disposal systems in low-income countries, and their use is on the rise as countries aim to meet the sanitation-related target of the Millennium Development Goals. There is concern, however, that discharges of chemical and microbial contaminants from pit latrines to groundwater may negatively affect human health.

Objectives: Our goals were to a) calculate global pit latrine coverage, b) systematically review empirical studies of the impacts of pit latrines on groundwater quality, c) evaluate latrine siting standards, and d) identify knowledge gaps regarding the potential for …

Aids: An Overview, Loretta Mclaughlin

New England Journal of Public Policy

"We stand nakedly in front of a very serious pandemic, as mortal as any pandemic there ever has been," said Halfdan Mahler, director-general of the World Health Organization (WHO). "I don't know of any greater killer than AIDS, not to speak of its psychological, social and economic maiming. Everything is getting worse and worse with AIDS and all of us have been underestimating it, and I in particular. We're running scared. I cannot imagine a worse health problem in this century." When asked to compare AIDS to other epidemics, such as smallpox, that have infected and killed over the course …

The Work Environment Disability-Adjusted Life Year For Use With Life Cycle Assessment: A Methodological Approach, Kelly A. Scanlon, George M. Gray, Royce A. Francis, Shannon M. Lloyd, Peter Lapuma

Environmental and Occupational Health Faculty Publications

Background

Life cycle assessment (LCA) is a systems-based method used to determine potential impacts to the environment associated with a product throughout its life cycle. Conclusions from LCA studies can be applied to support decisions regarding product design or public policy, therefore, all relevant inputs (e.g., raw materials, energy) and outputs (e.g., emissions, waste) to the product system should be evaluated to estimate impacts. Currently, work-related impacts are not routinely considered in LCA. The objectives of this paper are: 1) introduce the work environment disability-adjusted life year (WE-DALY), one portion of a characterization factor used to express the magnitude of …

Is Obesity Socially Contagious?, Ciani Jean Sparks

Statistics

The main objective of this paper is to analyze three different articles that discuss whether obesity could be socially contagious. According to the World Health Organization in 2013, obesity is the fifth leading risk for deaths around the world. This disease has dramatically increased in the last decade, which has led scientists to believe there are other factors contributing to the epidemic besides genetics. The first article I analyzed, written by Nicholas Christakis and James Fowler, provided a logistic regression model to estimate the odds of a person becoming obese. The model included the explanatory variables: age, sex, education, smoking …

The Impact Of Volunteering On Seniors’ Health And Quality Of Life: An Assessment Of The Retired And Senior Volunteer Program, Theodore W. Mcdonald, Erica L. Chown, Jordan E. Tabb, Amy K. Schaeffer, Elsa K. M. Howard

Public and Population Health Faculty Publications and Presentations

Past research suggests that senior citizens often face challenges related to deteriorating physical and men- tal health, and the quality of their lives may suffer as a result. Past research also suggests that volunteering can improve the health and quality of life for seniors. In the present study, 451 volunteers enrolled in the Retired and Senior Volunteer Program (RSVP) completed surveys including questions regarding their volunteer experiences and how these experiences have affected their health and quality of life. The results suggest that volunteering through RSVP is associated with improvements in health and quality of life across a variety of …

Role Of Garlic Usage In Cardiovascular Disease Prevention: An Evidence-Based Approach, Waris Qidwai, Tabinda Ashfaq

Department of Family Medicine

Introduction:.Rapidly growing prevalence of cardiovascular disease is a major threat for the developed as well as developing world warranting urgent need of intervention. Complementary and alternative medicines are gaining popularity among general population because of their safety profile and easy administration. Garlic, in particular, is considered to be one of the best disease-preventive foods because of its potent and widespread effects. This study was done to find out the role of garlic usage in cardiovascular disease prevention.

Methodology : .Major databases including Google, PubMed,MEDLINE, and Cochrane library view were used for the literature search. Clinical trials conducted on humans assessing …

Perceptions Of Herbal Remedies Among California Polytechnic University, San Luis Obispo Students, Maria Cacciatore, Kimmie Layland, Nicole Morrisey

Social Sciences

Many practitioners now recognize that herbal remedies can be an effective and natural alternative to the standard American, western biomedicine. The objective of our research project is to discover the perceptions about herbal remedies as alternative medicine among Cal Poly students. Specifically we ask, why are they chosen and how students gauge their effectiveness. We seek to see if students have experimented with these herbal remedies, why they chose this route for wellness, and how they value the use of herbal alternative. If we are successful in this project, we will have a greater understanding of how young educated adults …

Whyte '91 Joins Chicago Public Schools As Chief Health Officer, Katherine Filippo

News and Events (Discontinued Series)

No abstract provided.