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Changes In Cardiovascular Risk Factors And Health Care Expenditures Among Patients Prescribed Semaglutide, Yuan Lu, Yuntian Lu, Tedi Totojani, Chungsoo Kim, Rohan Khera, Hua Xu, John E. Brush Jr., Harlan M. Krumholtz, Jason Abaluck

Department of Medicine Faculty Publications

Importance Semaglutide, a glucagon-like peptide-1 receptor agonist, has demonstrated substantial weight reduction and cardiovascular benefits in clinical trials. However, its association with clinical outcomes and health care expenditures remains underexplored.

Objective To evaluate changes in cardiovascular risk factors and health care expenditures among patients prescribed semaglutide across multicenter cohorts.

Design, Setting, and Participants This retrospective cohort study included 23 522 adults (≥18 years) who received an initial semaglutide prescription between January 1, 2018, and January 1, 2025, at Sentara Healthcare and between January 1, 2018, and May 1, 2025, at Yale New Haven Health System.

Exposure The first prescription of …

Navigating Ethical Complexities In Health Education: Exploring Challenges In Teaching Food And Health, E. Oljans, M. Quennerstedt, D. Barker, A. Caldeborg, V. Varea

Research outputs 2022 to 2026

Teaching food and health may be challenging, especially in classrooms where young people from different cultures, ethnicities, and religions meet. This article explores teachers’ navigation of ethical complexities when teaching food and health in classrooms with immigrant students. Five didactical strategies were identified: (1) The educare strategy, (2) The tiptoeing strategy, (3) The collegial support strategy, (4) The intercultural strategy, and (5) The pluralistic strategy. These didactical strategies are embedded in various educational settings. Our results demonstrate that a further focus on ethical and intercultural competence should be carefully supported and implemented in teacher education and continual professional development programmes …

Faktor Determinan Kasus Diabetes Mellitus Tipe 2 Di Kabupaten Administrasi Kepulauan Seribu Provinsi Dki Jakarta Tahun 2023, Ulinuha Setya Darmawanti

Jurnal Epidemiologi Kesehatan Indonesia

Kepulauan Seribu Administrative District has the highest Diabetes Mellitus Incidence Rate compared to other areas in the DKI Jakarta Province, which is 317.4 per 10,000 residents. The purpose of this research is to identify the determinant factors that most influence cases of Type 2 Diabetes Mellitus in the Kepulauan Seribu in 2023, based on the relationship between factors such as Age, Gender, Occupation, History of Diabetes Mellitus, Body Mass Index (BMI), Excessive Sugar Consumption, Excessive Salt Consumption, Excessive Fat Consumption, Insufficient Fruit and Vegetable Intake, and Lack of Physical Activity. This research employs an analytical observational study method with a …

The Correlation Of Covid-19 Vaccination With Covid-19 Patient Mortality In Depok City, Indonesia, Dian Nugrahari, Asri Adisasmita Prof, Nurhanifah Hamdah

Jurnal Epidemiologi Kesehatan Indonesia

Vaccination is a disease prevention method recommended by the WHO as it will reduce disease severity, mortality rate and risks. The objective of this study is to discover the impact of COVID-19 vaccination against COVID-19 mortality rate in Indonesia. This was a retrospective cohort research on the data from the NAR COVID-19 database and the KPCPEN COVID-19 Dashboard of the Depok City Health Department from May 2020-February 2023. We performed a Cox proportional hazard analysis to obtain the risk for death. We discovered that COVID-19 vaccination reduced the mortality until it was less than 10% of unvaccinated population (0,24% for …

Asosiasi Antara Indeks Massa Tubuh Dan Mortalitas Pada Pasien Gagal Ginjal Kronis Yang Menjalankan Hemodialisa Reguler: Meta-Analisis Dari Studi Kohort, Joue Abraham Trixie Latupeirissa, Mondastri Korib Sudaryo, Dorothy Gabriella Ms., Benedikta Suryandari Ms., Vine Aprilianita Sri Indah Putri Ms.

Jurnal Epidemiologi Kesehatan Indonesia

Chronic kidney failure patients must undergo hemodialysis for life, therefore it is important to maximize hemodialysis services in every health facility. Accordingly, factors related to survival rates must be addressed. One of them is low Body Mass Index (BMI). This study assessed the relationship between low BMI and mortality in the patients. The study design used was meta-analysis. The articles involved were in the period 2012 - 2024. There are three literature sources: medical databases, previous studies, and ongoing research. Overall, 26 articles were obtained. Data analysis showed that BMI

The Impact Of Smoking Degree On One Year Survival Of Non-Small Cell Lung Cancer (Nsclc) At Persahabatan Hospital, Arief Wicaksono, Asri C. Adisasmita, Andika Chandra Putra

Jurnal Epidemiologi Kesehatan Indonesia

Lung cancer is a major global mortality problem with the worst prognosis compared to other types of cancer. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer and smoking is one of the main factors causing lung cancer. This study aims to determine the one-year survival of NSCLC patients with smoking levels and to determine what factors affect survival. This study is an observational study with a retrospective method, looking at medical record data of NSCLC patients both inpatients and outpatients at Persahabatan Hospital between January 2023 and December 2023 and then followed up until September …

Hubungan Antara Obesitas Abdominal Dengan Kejadian Stroke Pada Penduduk Usia Dewasa Dan Paruh Baya : Tinjauan Literatur, Jessica Veronica Silalahi, Sudarto Ronoatmodjo

Jurnal Epidemiologi Kesehatan Indonesia

Stroke is a major and growing global health problem. Stroke is a leading cause of illness and death worldwide and can be broadly classified as hemorrhagic stroke or ischemic stroke. There are many risk factors for stroke, including modifiable and non-modifiable risk factors. This study aims to investigate the correlation between central obesity and stroke incidence in adults and middle-aged using a systematic review. This study was conducted through a comprehensive search of several electronic databases, including Scopus, Science Direct, Proquest, and Google Scholar from June 2024 - September 2024. A total of 2,482 articles were screened based on the …

Hubungan Gangguan Mental Emosional Dan Obesitas Sentral: Literature Review, Dwi Rahmawati, Ratna Djuwita

Jurnal Epidemiologi Kesehatan Indonesia

The prevalence of central obesity, both globally and in Indonesia, continues to increase. Mental and emotional disorders are one of the contributing factors to central obesity. In previous studies, it was known that the relationship between emotional mental disorders and obesity can occur in bidirections, where emotional mental disorders can cause central obesity or vice versa. This literature review aims to find out more about the relationship between emotional mental disorders and central obesity from various countries. The searching for articles used 4 databases (Scopus, Science Direct, Proquest, and Pubmed) with the Preferred Reporting Items for Systematic Review and Meta-Analysis …

Factors Affecting The Adoption Of Malaria Interventions For Pregnant Women In Tanzania: Tanzania Demographic Health Survey 2022, Melisa Nyamukondiwa, Asri C. Adisasmita, Renti Mahkota, Same Betera

Jurnal Epidemiologi Kesehatan Indonesia

Tanzania is endemic to malaria and pregnant women due to their vulnerability are among the high-risk groups. The adoption of malaria interventions targeted to pregnant women is affected by a number of factors. A cross-sectional study using secondary data from Tanzania Demographic Health Survey (TDHS) for 2022 was used. A logistic regression was used for bivariate analysis to identify factors affecting the adoption of malaria interventions during pregnancy in Tanzania. Data from pregnant women between 15 to 49 years (N=1408) were analyzed in this study. Insecticide treated nets (ITNs) and intermittent preventive therapy in pregnancy using sulfadoxine-pyrimethamine (IPTp-SP) were the …

The Relationship Between Breast Milk Coverage, Mother's Education Level, Sanitation Hygiene, And Infectional Diseases And Incidents Of Stunting In Toddler In Bangkalan District, East Java, Septa Katmawanti, Achmad Masfi, Ronal Surya Aditya, Dea Aflah Samah, Fatiya Rizka Putri, Oktavia Sri Wahyuni, Muhammad Fahmi Rabbani, Purnama Devita Sari

Preventia: The Indonesian Journal of Public Health

Stunting remains a pressing global health issue, with 149 million children affected in 2020. In Bangkalan District, East Java, stunting prevalence reaches 25.2 percent, exceeding the provincial average of 19.2 percent. This study aimed to analyze factors influencing stunting, including breastfeeding coverage, maternal education, hygiene, and infectious diseases. Conducted from August to September 2023 in the Blega Health Center area, this analytical correlation study involved 35 toddlers aged 24–59 months selected through simple random sampling. Data were collected via questionnaires, anthropometric measurements, and interviews, then analyzed using chi-square tests in SPSS. The results revealed significant relationships between exclusive breastfeeding and …

Prevention Of Obesity In The Elderly Through Health Promotion Interventions: Literature Review, Miranda Gracia Salsabila, Ernawaty Ernawaty, Indah Berliana Fauziah

Preventia: The Indonesian Journal of Public Health

The incidence of obesity among the elderly is rising in many countries, including Indonesia. To address this issue, effective interventions are necessary to change lifestyle and dietary habits, such as through social marketing and health promotion initiatives for the elderly. Preventing obesity in this demographic through social marketing can involve educational campaigns, intervention programs, community empowerment, and collaboration with various stakeholders. This study aims to identify strategies to prevent obesity in the elderly through health promotion interventions. The study is a literature review following the PRISMA 2009 protocol. Articles were sourced from Google Scholar, ScienceDirect, and PubMed databases, focusing on …

Relationship Between Personal Hygiene And Environmental Sanitation To The Presence Of Escherichia Coli Bacteria In Food, Erica Ardhana Fathimah Azzahra, Vivi Novianti, Muhammad Al-Irsyad

Preventia: The Indonesian Journal of Public Health

Food safety is one of the significant public health issues, especially in developing countries. The extraordinary incidence of food poisoning and a high number of cases of gastrointestinal infections in Malang City indicate infection with the bacteria that cause dysentery, namely E.coli. This study evaluated hygiene-sanitation practices at food stalls in Area Terusan Ambarawa Malang City. This study aimed to identify Escherichia coli bacteria in 11 food stalls and assess the relationship of environmental sanitation and personal hygiene of food handlers to the presence of E.coli. This study used a quantitative descriptive design with a cross-sectional approach, data collection using …

Association Between Knowledge, Attitude, And Practice On Dietary Fiber Intake And Body Mass Index Among Undergraduate Students In Universiti Kebangsaan Malaysia, Arimi Fitri Mat Ludin, Munirah Ismail, Mohd Sham Othman, Divya Vanoh, Chai Huoy Tyng, Irdina Ibrahim, Jasmine Lavang Surang, Muhammad Adam Jayiddin, Noor Afiifah Ibrahim, Nur Arina Shazrina Abdullah, Nur Athirah Harun, Nur Fatihah Rashidi, Lew Leong Chen

Makara Journal of Health Research

Background: A fiber-rich diet lowers the risk of various diseases by increasing fecal bulk, shortening intestinal transit time, and stimulating intestinal flora. This study examines the association between knowledge, attitude, and practice (KAP) regarding dietary fiber intake and body mass index (BMI) among Dentistry and Software Engineering undergraduates.

Methods: This cross-sectional study included 95 Dentistry and 92 Software Engineering students at the Universiti Kebangsaan Malaysia. The KAP questionnaire was analyzed for its reliability using Cronbach’s alpha and distributed through email.

Results: Most respondents had normal weight. The Software Engineering students had a higher percentage of overweight and …

Threat Of Hypercholesterolemia In Urban Adults And Its Associates: Evidence From A Community-Based Study, Ambika Rani Yadav, Priya Keshari

Makara Journal of Health Research

Background: Hypercholesterolemia is an abnormality of lipids. It is a crucial modifiable risk factor for cardiovascular diseases. There is a paucity of community-based studies on hypercholesterolemia in the adult population in India. Given this context, the study aims to assess the prevalence and spectrum of hypercholesterolemia, along with its associated factors, among adult residents of urban areas in Prayagraj district, Uttar Pradesh, India.

Methods: This community-based cross-sectional study was done on 536 urban adult subjects (30 to 59 years) of Prayagraj, India, selected by multistage sampling procedure. The predesigned and pretested interview schedule was used to obtain socio-demographic …

Orthogonal And Multiplexable Genetic Perturbations With An Engineered Prime Editor And A Diverse Rna Array, Qichen Yuan, Hongzhi Zeng, Tyler C Daniel, Qingzhuo Liu, Yongjie Yang, Emmanuel C Osikpa, Qiaochu Yang, Advaith Peddi, Liliana M Abramson, Boyang Zhang, Yong Xu, Xue Gao

Faculty, Staff and Students Publications

Programmable and modular systems capable of orthogonal genomic and transcriptomic perturbations are crucial for biological research and treating human genetic diseases. Here, we present the minimal versatile genetic perturbation technology (mvGPT), a flexible toolkit designed for simultaneous and orthogonal gene editing, activation, and repression in human cells. The mvGPT combines an engineered compact prime editor (PE), a fusion activator MS2-p65-HSF1 (MPH), and a drive-and-process multiplex array that produces RNAs tailored to different types of genetic perturbation. mvGPT can precisely edit human genome via PE coupled with a prime editing guide RNA and a nicking guide RNA, activate endogenous gene expression …

From Surviving To Thriving: Key Considerations For Weight Control Across Diverse Cancer Survivorship Populations, Justin C. Brown, Marlyn Allicock, Carmina G. Valle, Tanya Agurs-Collins

School of Medicine Faculty Publications

BACKGROUND: Obesity is a chronic, relapsing, progressive disease of excess adiposity that increases the risk of dying from at least 16 types of cancer. The prevalence of obesity has increased more rapidly in cancer survivors compared with the general population. Tailored weight management strategies are needed to improve prognosis and health outcomes in the growing population of cancer survivors. However, certain cancer survivor population subgroups require unique consideration when developing weight management strategies. METHODS: In a symposium convened by The Obesity Society during ObesityWeek 2023 titled "From Surviving to Thriving: Key Considerations for Weight Control Across Diverse Cancer Survivorship Populations," …

Effect Of Improving Food Security On Parenting Practices And Caregiver–Adolescent Relationships: Qualitative Findings Of An Income-Generating Agricultural Intervention In Rural Kenya, Maricianah A. Onono, Lila Sheira, Edward A. Frongillo Jr., Gladys Odhiambo, Pauline Wekesa, Amy Conroy, Elizabeth A. Bukusi, Craig R. Cohen, Sheri D. Weiser

Faculty Publications

Background

Despite the recognised links between food insecurity and parenting, few studies have evaluated the perceived impacts of livelihood or food security interventions on parental practices, intra-household functioning, adolescent behaviour and psychosocial outcomes in HIV-affected households in sub-Saharan Africa.

Aims

The study aimed to understand the perceived effects of food security on parenting practices and how this was experienced by both adolescent girls (aged 13–19 years) and their caregivers in rural Kenya.

Method

We conducted semi-structured, individual interviews with 62 caregiver–adolescent dyads who were participants in the adolescent Shamba Maisha (NCT03741634), a sub-study of adolescent girls and caregivers with a …

Impact Of American Thyroid Association's Revised Cancer Management Guidelines On Thyroid Cancer Incidence Trends: A Retrospective Cohort Study, 2000-2020, Pierre Fwelo, Natalia I Heredia, Ruosha Li, Ayrton Bangolo, Vignesh K Nagesh, Simcha Weissman, Xianglin L Du

Faculty, Staff and Student Publications

Background: The past four decades have seen a steady increase in thyroid cancer in the United States (US). This study investigated the impact of the American Thyroid Association (ATA)'s revised cancer management guidelines on thyroid cancer incidence trends and how the trends varied by socioeconomic, histologic, geographic, and racial and ethnic characteristics from 2000 to 2020.

Methods: We used data from the Surveillance, Epidemiology, and End Results (SEER) database to identify thyroid cancer cases diagnosed among US patients between 2000 and 2020. We employed joinpoint regression software to fit, assess, and compare thyroid cancer incidence trends over time stratified by …

Health Literacy On Physical Therapy Among Senior Citizens With Physical Disability And Community Health Workers, Kriza G. Ganotisi, Faye Angelene J. Barangay, Andrew A. Galang, Wina Frances Q. Lazaro, Christopher U. Rivera, Ryan Dean T. Sucgang

Philippine Journal of Physical Therapy

Introduction. This study was conducted to determine the health literacy on physical therapy (PT) among senior citizens with physical disability and community health workers (CHWs). Specifically, it identified the sociodemographic profile of the CHWs and senior citizens with physical disability, their extent of health literacy on PT as to prose, document and numeracy and how health policies, availability of PT programs, and available equipment and facilities for the rendition of PT services affect their health literacy.

Methods. This study employed a descriptive research design. The respondents of the study involved 18 CHWs and 29 senior citizens. It was conducted in …

Improved Adherence To Lipid Screening In The Pediatric Cardiology Clinic: A Quality Improvement Project, Rachel Magnan, Thomas Murphy, Lauren Rosenthal, Aparna Prasad, Anjali Chelliah, Stuart Kaufman, Donna Timchak, Lindsey Mcphillips, Saira Siddiqui

Department of Pediatrics Faculty Papers

INTRODUCTION: Lipid screening identifies at-risk patients to facilitate cardiovascular risk reduction. National pediatric guidelines recommend universal lipid screening between 9-11 and 17-21 years of age. We aimed to improve adherence to lipid screening for all age-appropriate outpatient pediatric cardiology visits from a baseline of 35% to 90% between November 2021 and July 2023.

METHODS: All outpatient visits for patients 9-11 and 17-21 years were included. Chart review and an Epic electronic health record report identified patients screened, lipid test results, and need for further testing. A P-chart was generated. After establishing a baseline for 8 weeks, interventions, including an Epic …

Importance Of The Hemoglobin Glycation Index For Risk Of Cardiovascular And Microvascular Complications And Mortality In Individuals With Type 2 Diabetes (Endocrinol Metab 2024;39:732-47, Claudia Regina Lopes Cardoso Et Al.), Stuart A. Chalew

School of Medicine Faculty Publications

No abstract provided.

Sparkled: Social Programming In Kids Affects Risk Of Latent Endothelial Disease, Rebecca Drakowski

Theses & Dissertations

Background: Social Health Programming (SHP) is a holistic intervention that can empower communities to address modifiable risk factors for poor cardiovascular health, including suboptimal nutrition or psychosocial stressors. SHP participation has been shown to increase dietary intake of fruits and vegetables, decrease perceived stress, and improve cardiovascular endurance. However, it is unknown how SHP participation during adolescence affects carotenoid serum levels, hair cortisol concentrations (biological marker of chronic stress), or vascular reactivity index (VRI; measure of subclinical cardiovascular health).

Methods: Adolescent girls and young adult women (12–29-year-old) were enrolled in this observational cohort study. Serum, hair, and saliva samples were …

Efficacy Of Probiotics For Treatment Of Acute Or Persistent Diarrhoea In Children From Birth Till 10 Years: Systematic Review And Meta-Analysis, Anmol Minaz, Ridwa Alam, Uswa Jiwani, Khadija Vadsaria, Ahmad Khan, Aqsa Ishaq, Samar Sultan, Marium Mohsin, Ashraf Sharif, Yasir Bin Nisar, Jai K. Das, Sajid Bashir Soofi, Shabina Ariff

Centre of Excellence in Women and Child Health

Background: Numerous studies have investigated the efficacy of probiotics in treating acute and persistent diarrhoea. However, probiotics have not been established as a recommended management option for diarrhoeal illness by the World Health Organization (WHO). Therefore, we conducted a systematic review of randomised controlled trials to assess the efficacy of probiotics for the management of acute and persistent diarrhoea in children.
Methods: A systematic search on PubMed, CINAHL, Wiley Cochrane Library, Scopus, Clinicaltrials.gov, and WHO International Clinical Trials Registry Platform (ICTRP) was performed. All studies published in the year 2000 and onwards that assessed the use of probiotics in the …

The Camden Study - A Pregnancy Cohort Study Of Pregnancy Complications And Birth Outcomes In Camden, New Jersey, Usa., Stephanie Shiau, Xinhua Chen, Ayana April-Sanders, Ellen C Francis, Shristi Rawal, Megan Hansel, Kehinde Adeyemi, Zorimar Rivera-Núñez, Emily S Barrett

Rowan-Virtua School of Osteopathic Medicine Departmental Research

BACKGROUND: Pregnancy is a unique stage of the life course characterized by trade-offs between the nutritional, immune, and metabolic needs of the mother and fetus. The Camden Study was originally initiated to examine nutritional status, growth, and birth outcomes in adolescent pregnancies and expanded to study dietary and molecular predictors of pregnancy complications and birth outcomes in young women.

METHODS: From 1985-2006, 4765 pregnant participants aged 12 years and older were recruited from Camden, NJ, one of the poorest cities in the US. The cohort reflects a population under-represented in perinatal cohort studies (45% Hispanic, 38% non-Hispanic Black, 17% White …

Community, State And Professionalism: Negotiating The Experience Of Community Health Workers In The Provision Of Maternal And Child Health Services In Tanzania, Chakupewa Joseph Mpambije

Journal of Humanities and Social Sciences

Research on community health workers (CHWs) has been on the increase in the past decades in Tanzania, focusing on the provision of maternal and child health (MCH) services. While performing their tasks, CHWs work within three constructs: the community, the state, and their professionalism. However, as CHWs work within these constructs, there exists scanty literature which discourses their experiences within the realm of the community, the state and their professionalism. This review aimed to articulate how these constructs facilitate or inhibit CHWs’ performance in improving MCH services. It employed a scoping review method in which peer-reviewed articles and grey literature …

Unraveling The Relationship Between Sleep Behaviors And Physical Activity In The United States: Insights From 2015 To 2020 Nhanes Data, Deepali K Ernest, Bipin Singh, Fathimath Shamna, Elizabeth A Onugha, Shreela V Sharma

Faculty, Staff and Student Publications

Background: Physical activity is an important component of metabolic health. However, little is known about the impact of specific types/intensities of physical activity on sleep health, especially among ethnically diverse populations. We examined the association of various sleep behaviors with moderate to vigorous work/recreational activity.

Methods: Self-reported data from the National Health and Nutrition Examination Survey 2015-2020 were cross-sectionally analyzed for a sample of 11,039 participants in the United States (U.S.). Weighted univariate logistic regressions determined unadjusted associations, while weighted multivariable regression models adjusting for age, sex, ethnicity, BMI categories, and socio-economic status assessed the multivariable associations with moderate and …

Pathways From Socioeconomic Factors To Major Cardiovascular Events Among Postmenopausal Veteran And Nonveteran Women: Findings From The Women's Health Initiative, Hind A Beydoun, May A Beydoun, Rebecca L Kinney, Simin Liu, Rona Yu, Matthew Allison, Robert B Wallace, Qian Xiao, Longjian Liu, Philippe Gradidge, Su Yon Jung, Hilary A Tindle, Shawna Follis, Robert Brunner, Jack Tsai

Faculty, Staff and Student Publications

BACKGROUND: Cardiovascular disease (CVD) remains a leading cause of death for women in the United States, with veterans being at potentially higher risk than their nonveteran counterparts due to accelerated aging and distinct biopsychosocial mechanisms. We examined pathways between selected indicators of socioeconomic status (SES) such as education, occupation, household income, and neighborhood SES and major CVD events through lifestyle and health characteristics among veteran and nonveteran postmenopausal women.

METHODS AND RESULTS: A total of 121 286 study-eligible WHI (Women's Health Initiative) participants (3091 veterans and 118 195 nonveterans) were prospectively followed for an average of 17 years, during which …

Comparing Multivalent Cross-Linked Sodium Alginate/ Montmorillonite Beads Containing Curcumin Or Cayenne Pepper As Drug Carriers And Their Antimicrobial Resistance, Shionainn Traynor, Shubham Sharma

SURE Journal: Science Undergraduate Research Experience Journal

The aim of the following work was to investigate and compare curcumin and cayenne pepper in microbeads composed of sodium alginate (SA) crosslinked with montmorillonite (MMT) to act as drug carriers and their antimicrobial resistance. The microbeads were prepared through ion-exchange in multivalent solutions of CaCl₂, MgCl₂ and AlCl₃. The microbeads were characterized by Scanning Electron Microscopy (SEM), Energy Dispersive X-ray analysis (EDX) and the time required for intercalation of curcumin and cayenne pepper with MMT. Simulated intestinal fluid (pH 7.3) and gastric fluid (pH 1.2) at 37°C were used for comparison in swelling studies. …

Association Between Body Mass Index, Abdominal Obesity And Menopause-Related Symptoms In Postmenopausal Women, Brianna A. Rice, Patricia Heavey

SURE Journal: Science Undergraduate Research Experience Journal

Abstract: Existing research demonstrates a lack of data on the relationship between body mass index (BMI) and menopause-related symptoms in postmenopausal women, particularly in Ireland. This study aimed to determine whether there is an association between BMI, general abdominal obesity and menopause-related symptoms in postmenopausal women. This should help bridge the data gap regarding postmenopausal women living in Ireland and their symptoms. Introduction: Menopause is defined as the permanent cessation of a woman's menstrual cycle. This is caused by a reduction of the secretion of oestrogen and progesterone, leading to reduced ovarian function. These changes have been attributed …

Investigation Into The Effect Of Aspartame On The Expression Of P53 And Bax In Mouse Stomach Tissue, Angelique Cheryl, Aoife Mac Cooey

SURE Journal: Science Undergraduate Research Experience Journal

Introduction: The recent reclassification of aspartame as a Group 2B hazard by the International Agency for Research on Cancer, along with studies suggesting links to cancer, has raised concerns and prompted further investigation. Evidence suggests that aspartame exposure may alter p53 and BAX gene expression, affecting apoptosis in cancer cells. This study aims to examine how aspartame exposure affects p53 and BAX gene expression in normal mouse stomach tissue, shedding light on cellular stress and apoptosis mechanisms.

Methods: Mice were sacrificed, and stomach tissue was excised and divided into control and treatment groups. RNA extraction was carried out in the …