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Articles 3001 - 3030 of 12234
Full-Text Articles in Entire DC Network
Public Health Implications: A Scoping Review Of Opioid Prevention Programs Among Adolescents, Joseph Donnelly, Elena Saldutti, Lisa Ellis Gavin, Michael Hecht
Public Health Implications: A Scoping Review Of Opioid Prevention Programs Among Adolescents, Joseph Donnelly, Elena Saldutti, Lisa Ellis Gavin, Michael Hecht
Department of Public Health Scholarship and Creative Works
This article presents a comprehensive review of the pressing issue of adolescent opioid and fentanyl deaths and overdoses, highlighting the urgent need for effective prevention strategies and educational interventions. The escalating crisis of opioid abuse among adolescents necessitates immediate attention from drug educators, concerned parents, and society as a whole. We examine the alarming rise in adolescent opioid and fentanyl-related fatalities, emphasizing the unique challenges posed by fentanyl's potency and the dangerous allure it holds for young individuals. By analyzing existing harm reduction strategies, we underscore the crucial role they play in mitigating the devastating consequences of opioid use. Moreover, …
Passive Earplug Including Helmholtz Resonators Arranged In Series To Achieve Broadband Near Zero Occlusion Effect At Low Frequencies, Kevin Carillo, Franck Sgard, Olivier Dazel, Olivier Doutres
Passive Earplug Including Helmholtz Resonators Arranged In Series To Achieve Broadband Near Zero Occlusion Effect At Low Frequencies, Kevin Carillo, Franck Sgard, Olivier Dazel, Olivier Doutres
Études primaires
The use of passive earplugs is often associated with the occlusion effect: a phenomenon described as the increased auditory perception of one's own physiological noise at low frequencies. As a notable acoustic discomfort, the occlusion effect penalizes the use and the efficiency of earplugs. This phenomenon is objectively characterized by the increase in sound pressure level in the occluded ear canal compared to the open ear canal. Taking inspiration from acoustic metamaterials, a new design of a three-dimensional printed “meta-earplug,” made of four Helmholtz resonators arranged in series, is proposed for achieving near zero objective occlusion effect measured on artificial …
Prerequisite For Imputing Non-Detects Among Airborne Samples In Osha’S Imis Databank: Prediction Of Sample’S Volume, Igor Burstyn, Philippe Sarazin, George Luta, Melissa C. Friesen, Laurel Kincl, Jérôme Lavoué
Prerequisite For Imputing Non-Detects Among Airborne Samples In Osha’S Imis Databank: Prediction Of Sample’S Volume, Igor Burstyn, Philippe Sarazin, George Luta, Melissa C. Friesen, Laurel Kincl, Jérôme Lavoué
Études primaires
Introduction: The US Integrated Management Information System (IMIS) contains workplace measurements collected by Occupational Safety and Health Administration (OSHA) inspectors. Its use for research is limited by the lack of record of a value for the limit of detection (LOD) associated with non-detected measurements, which should be used to set censoring point in statistical analysis. We aimed to remedy this by developing a predictive model of the volume of air sampled (V) for the non-detected results of airborne measurements, to then estimate the LOD using the instrument detection limit (IDL), as IDL/V.
Methods: We obtained the Chemical Exposure Health Data …
Nature Based Interventions For Human Health And Wellbeing, Samantha I. Moyers
Nature Based Interventions For Human Health And Wellbeing, Samantha I. Moyers
Graduate Theses, Dissertations, and Problem Reports (ETD)
Background. Nature exposure is beneficial to human health and wellbeing, but the evidence base for nature-based interventions (NBI) is still developing. Heterogeneous naming conventions, study designs, and intervention contexts create difficulty in accessing and assessing the evidence for such programming. While NBI have been utilized in a wide array of human populations, no interventions have been reported among clinical health professions students. Aims. The objectives of this dissertation project were to review the existing body of NBI literature exploring health and wellbeing outcomes, and to conduct a feasibility trial of forest bathing, a type of NBI, among clinical students. Specifically, …
Understanding The Effects Of The Covid-19 Pandemic On West Virginia Students In Secondary School, Hannah Mckenzye Layman
Understanding The Effects Of The Covid-19 Pandemic On West Virginia Students In Secondary School, Hannah Mckenzye Layman
Graduate Theses, Dissertations, and Problem Reports (ETD)
Abstract 1
Background: The COVID-19 pandemic negatively impacted the mental health of young people. Mental health disparities among youth are abundant, so understanding how the pandemic may have affected specific sub-groups to develop tailored interventions to mitigate variations in health disparities is essential. Methods: School-based survey data from the Young Mountaineer Health Study (YMHS) was used to create generalized estimating equations models predicting anxiety and depression among early adolescents. The cohort sample included 2,322 students. Waves 1, 2, and 3 were collected ~6 months apart. Independent variables included COVID-19-related emotional impact (scale range: 5-25) and social support. Results: Average age …
Awareness Of The Role Of Nutrition In Cancer Causation And Prevention Among Rural Adult Population: A Cross-Sectional Study, Sayana Basheer, Kavya G. Upadhya, Sana Khader M
Awareness Of The Role Of Nutrition In Cancer Causation And Prevention Among Rural Adult Population: A Cross-Sectional Study, Sayana Basheer, Kavya G. Upadhya, Sana Khader M
Digital Journal of Clinical Medicine
Background
In recent years, nutrition has received an increasingly important role in the aetiology of cancer. Thus, public education about dietary factors associated with cancer risk or prevention could be an important intervention for cancer prevention, particularly in low- and middle-income countries where the burden of cancer is increasing rapidly and access to care is limited. This study aimed to assess the awareness among rural adults about the role of nutrition in cancer development and its prevention.
Methods
A cross-sectional study was conducted among 300 individuals in the adult population (> 18 years) in rural field practice area of a …
Nutritional Medicine: Education For Advanced Practice Providers, Natalie Organ
Nutritional Medicine: Education For Advanced Practice Providers, Natalie Organ
DNP Research Projects
Abstract
OBJECTIVE: The project's primary goal was to educate the APP and develop positive attitudes and beliefs concerning plant-based nutrition regarding obesity, diabetes, cardiovascular disease, and cancer. The project addressed a crucial gap in healthcare education. APPs were not routinely given the chance to learn nutritional medicine, leading to decreased confidence in providing nutritional guidance in clinical practice.
METHODS: The DNP project participants were practicing advanced practice providers. The Knowledge, Attitude, Behavior (KAB) education theory and CREATION Life were used. This project used Qualtrics to send a pre-and post-intervention survey titled Student Survey for Nutritional Medicine. The intervention was a …
Hpv Vaccine Hesitancy In The Adolescent Population, Angela Parrish
Hpv Vaccine Hesitancy In The Adolescent Population, Angela Parrish
Graduate Research Projects
No abstract provided.
Marine And Human Environmental Factors Influence Vibrio Parahaemolyticus And Vibrio Vulnificus In Vitro Biofilm Processes On Plastics, Ryan Eric Leighton
Marine And Human Environmental Factors Influence Vibrio Parahaemolyticus And Vibrio Vulnificus In Vitro Biofilm Processes On Plastics, Ryan Eric Leighton
Theses and Dissertations
Marine bacteria often exist in biofilms as communities attached to surfaces, like plastic. Growing concerns exist regarding marine plastics acting as potential vectors of pathogenic Vibrio, especially in a changing climate. It has been generalized that Vibrio vulnificus and Vibrio parahaemolyticus often attach to plastic surfaces. Different strains of these Vibrios exist having different growth and biofilm forming properties. This work evaluated how temperature and strain variability affect V. parahaemolyticus and V. vulnificus biofilm formation and characteristics on glass (GL), low-density polyethylene (LDPE), polypropylene (PP), and polystyrene (PS). This work also evaluated how human body related factors like temperature, …
Lived Experiences Of College-Educated Black Women: Contextualizing Gendered Racial Health Disparities, Christiana L. Johnson
Lived Experiences Of College-Educated Black Women: Contextualizing Gendered Racial Health Disparities, Christiana L. Johnson
Theses and Dissertations
Black women are disproportionately affected by gendered racial health disparities. Public health research that seeks to unearth the root cause of these gendered racial health disparities is insufficient. More recently, researchers have turned their attention to structural inequities and their influence on the lived experiences of Black women. This study contributes to this body of work by using a theoretical concept derived from intersectionality⎯structural gendered racism⎯to identify key upstream social factors that shape nulliparous, college-educated Black women's lived experience and childbearing desires. Semi-structured, individual interviews were conducted with nulliparous, college-educated Black women (n=30), ages 25 to 35, living in the …
“My Ob/Gyn Has The Worst Bedside Manner…” A Qualitative Analysis Of Patient-Provider Communication And Mental Health Outcomes Of Women In Rural Georgia, Tobi F. Oloyede
“My Ob/Gyn Has The Worst Bedside Manner…” A Qualitative Analysis Of Patient-Provider Communication And Mental Health Outcomes Of Women In Rural Georgia, Tobi F. Oloyede
College of Graduate Studies: Theses & Dissertations
Despite technological advances in medicine and public health innovations, maternal mortality in the United States remains significantly higher than in other developed countries. Specifically, Georgia ranks as the second worst place to give birth in the country. Maternal mental health conditions are common, manageable complications that can happen at any point during pregnancy, childbirth, or in the first year following delivery, with 1 in 5 women affected. Unfortunately, 75% of women who experience MMH symptoms are left untreated.
This study focuses on patient-provider communication through the birthing experiences of women who have been pregnant in Georgia to examine how their …
Factors Associated With Physical Activity Intent Among Adults With Multiple Sclerosis, Biebele Okpeahior
Factors Associated With Physical Activity Intent Among Adults With Multiple Sclerosis, Biebele Okpeahior
College of Graduate Studies: Theses & Dissertations
Introduction. Although research has highlighted the benefits of physical activity in people with Multiple Sclerosis (MS), they are still more likely to live an inactive lifestyle. There are limited studies that examine the relationship between physical activity and the Theory of Planned Behavior (TPB) among the MS population. This study aimed to explore the factors that associate with physical activity intent of adults with MS utilizing the constructs of the TPB. Methods. This study utilized a cross-sectional online survey done via a social media platform. There were 326 respondents to the survey and ultimately 249 surveys that met the criteria …
“It's Just Not Enough”: Examining The Experiences Of School-Based Sexual Health Education And Conversation Engagement With Trusted Adults Among Black Boys In Richmond, Va, Sharyn A. Dougherty
“It's Just Not Enough”: Examining The Experiences Of School-Based Sexual Health Education And Conversation Engagement With Trusted Adults Among Black Boys In Richmond, Va, Sharyn A. Dougherty
Theses and Dissertations
The Centers for Disease Control and Prevention estimate that youth make up a quarter of the sexually active population, yet account for half of the 20 million new sexually transmitted infections in the United States.In 2021, youth age 15-19 living in Virginia’s central region, which includes the Richmond Metropolitan area, had the second highest number of chlamydia cases and fourth highest number of gonorrhea cases among all age groups, with the highest rates among Black youth. The aim of this study is to explore the experiences of Black youth in Richmond, VA with school-based sexual health education (SHE) and their …
Effectiveness Of An Integrated Multilevel Early Child Development Intervention On Caregiver Knowledge And Behavior: A Quasi-Experimental Evaluation Of The Malezi Program In Tanzania, Gretchen Antelman, Josephine Ferla, Michelle M. Gill, Heather J. Hoffman, Teopista Komba, Amina Abubakar, Pieter Remes, Ola Jahanpour, Martha Mariki, Mary A. Mang’Enya, Roland Van De Ven
Effectiveness Of An Integrated Multilevel Early Child Development Intervention On Caregiver Knowledge And Behavior: A Quasi-Experimental Evaluation Of The Malezi Program In Tanzania, Gretchen Antelman, Josephine Ferla, Michelle M. Gill, Heather J. Hoffman, Teopista Komba, Amina Abubakar, Pieter Remes, Ola Jahanpour, Martha Mariki, Mary A. Mang’Enya, Roland Van De Ven
Institute for Human Development, East Africa
Background The quality of caregiving and the parent-child relationship is critical for early child development (ECD) and has been shown to be modifiable. This study evaluated an ECD project in Tanzania, assessing the effectiveness of radio messaging (RM) alone and a combined radio messaging/video job aids/ECD (RMV-ECD) intervention.
Methods This two-arm pre-post evaluation study enrolled a cohort of caregivers of children 0–24 months in four districts of Tabora region, following them for 9 months. ECD radio messages were broadcast on popular stations at least 10 times/day reaching all study districts. In two districts, community health workers (CHW), trained in UNICEF’s …
“For The Future, For Him, And For Our Life Together”: The Relationship Goals And Well-Being Of Persons Living With Dementia And Their Spousal Care Partners, Claire Leigh Szapary
“For The Future, For Him, And For Our Life Together”: The Relationship Goals And Well-Being Of Persons Living With Dementia And Their Spousal Care Partners, Claire Leigh Szapary
Public Health Theses
Background. Identities and dynamics in relationships can change when one spouse develops dementia. This study aimed to understand the various types of goals both spousal care partners and persons living with dementia (PLWD) have for their relationship, and to explore whether approach or avoidance goals were associated with individual wellbeing and relational support – as well as their partners’ wellbeing and support.
Methods. A secondary analysis of data from sixty-two spousal dyads where one partner has dementia was conducted. Thematic goal-type categories were determined through a card-sort content analysis methodology using participants’ brief qualitative responses to a question asking about …
Perceptions Of Adults With Type 1 Diabetes About Diabetes Management And Exercise, Meera Swaminath
Perceptions Of Adults With Type 1 Diabetes About Diabetes Management And Exercise, Meera Swaminath
Public Health Theses
This study was conducted to understand participants’ experiences with diabetes management and relationships with exercise for a sample of adults (27-65 years old) with Type 1 diabetes living in the United States and identify potential technological features for a digital health tool supporting physical exercise and diabetes management. The sample consisted of 12 participants living across the nation. Participants were recruited online, through social media and healthcare system platforms. Participant data was collected in the form of surveys and interviews and analyzed using a constructivist framework and thematic analysis. Findings were collapsed into four major themes: 1) making exercise decisions …
Associations Between Involvement In Shared Activities With Plwd, Relationship Closeness, And Loneliness Of Friends And Family, Marielle W. Quinn
Associations Between Involvement In Shared Activities With Plwd, Relationship Closeness, And Loneliness Of Friends And Family, Marielle W. Quinn
Public Health Theses
Objectives. To examine the association between self-reported relationship closeness, loneliness, and engagement in shared activities with a person living with dementia (PLWD) in a community sample of family members and friends of PLWD. Methods. Using data from a Qualtrics-administered online survey, we examined involvement in shared activities of 51 respondents who have or had a family, friend, or intimate relationship with a PLWD. Outcome variables included relationship closeness, measured with the Inclusion of Other (IOS) scale, and loneliness, measured using a revised three-item questionnaire from the UCLA loneliness scale. Results. The main findings of the study were as follows: 1. …
Towards A Saliva-Based Pcr Test For The Detection Of Mpox, Russell J. Thomas
Towards A Saliva-Based Pcr Test For The Detection Of Mpox, Russell J. Thomas
Public Health Theses
Current recommendations for the diagnosis of mpox (monkeypox) rely on lesion-swabs as the gold-standard specimen type even though many patients experience symptoms prior to lesion-onset. Earlier detection could bolster the mpox response by mitigating transmission and facilitating access to antiviral treatments. In this study, we validated five PCR assays and compared their detection of mpox virus DNA extracted from 30 saliva specimens collected into Spectrum SDNA-1000 tubes. We found the Logix Smart™ Mpox (2-Gene) RUO assay (Co-Diagnostics, Inc., Salt Lake City, UT) performed statistically significantly better than the other assays. Next, we tested five raw (unsupplemented) known-positive saliva samples in …
“To Live In The Body Of A Survivor ”: Unique And Cumulative Disaster Exposure And Mental Health In A Sample Of Hurricane Katrina Survivors, Noelle Serino
Public Health Theses
Introduction: Fueled by the escalation of climate change, weather-related disasters are increasing in frequency and severity. Existing research has documented the extensive harm induced by such disasters, yet few studies have examined how individuals’ psychological well-being fares when exposed to multiple, diverse threats, including other weather-related and public health disasters (e.g., COVID-19). As such, the present study explores posttraumatic and psychological distress in the context of unique and cumulative disaster exposure.Methods: The data utilized for this study came from the Resilience in Survivors of Katrina (RISK) Project. The sample was comprised of 381 predominantly Non-Hispanic Black (84.5%) women who experienced …
Recommendations For Climate Adaptation To Preserve Connecticut Drinking Water Quality And Quantity, Matthew Salvatore Di Vitto
Recommendations For Climate Adaptation To Preserve Connecticut Drinking Water Quality And Quantity, Matthew Salvatore Di Vitto
Public Health Theses
Climate change impacts drinking water both directly and indirectly. Increases in temperature, drought frequency, and precipitation are among the climate impacts which currently and are projected to affect water quality and quantity in the continental United States. These impacts limit access to clean and abundant water sources by damaging habitat, spreading toxic substances via runoff and favoring the growth of harmful algal blooms. States can learn from one another to adopt best practices and policies to increase water resilience around the country. This paper explores how Connecticut can employ strategies from the States of New York, New Jersey, Massachusetts, Minnesota, …
Understanding The Current Role Of Social Media In American Samoan Adolescent Lives, Mukund Desibhatla
Understanding The Current Role Of Social Media In American Samoan Adolescent Lives, Mukund Desibhatla
Public Health Theses
Purpose: This exploratory study investigated the social and cultural factors that shape social media use among adolescents in
American Samoa. Methods: This project was a secondary qualitative analysis. Methodological considerations included an
interpretivist approach to epistemology and alignment with the Fa’afaletui Pacific framework. Phenomenology methods were
used to “bracket” researcher biases. A 21st-century flexible coding approach proposed by Deterding et al. 2021 was applied
to the dataset [31]. Transcript excerpts were re-sorted by the index code: social media/technology as a predictor of mental
illness. An abductive thematic analysis, stemming from inductive and deductive reasoning, was used to analyze the codebook …
Effect Of Digital Public Health Campaigns By The World Health Organization On Self-Reported Behavior, Recall/Knowledge, And Attitude Toward Interventions Related To Covid-19: A Meta-Analysis, Zili Zhou
Public Health Theses
The COVID-19 pandemic highlighted the need for effective scientific communication. The success of public health interventions are largely dependent on public knowledge and behavior. With the global rise of social media usage, as well as the increased prevalence of social media advertisement campaigns, the platforms present a tool with the potential to be utilized by public health authorities to deliver information and influence broad populations within a short period of time. From 2020 to 2022, the World Health Organization conducted 58 social media campaigns, totaling 176 brand-lift studies, in partnership with Meta on the subject of COVID-19. The campaigns conveyed …
Exploring The Perceptions Of Genetics, Genetics Testing, And Science In People Of African Descent, Maame-Owusua Boateng
Exploring The Perceptions Of Genetics, Genetics Testing, And Science In People Of African Descent, Maame-Owusua Boateng
Public Health Theses
Background: Historical injustices towards Black populations in the United States have impacted how communities interact with medicine and public health such as medical experimentations, scientific racism, medical racism, and eugenics. Black communities are underrepresented in human genomics projects compared to those that identify as white or of European ancestry. Prior research has demonstrated that Black people are less likely to know about the availability of genetic testing for diseases and have less confidence in the benefits of genetic testing. These disparities make it imperative to understand the perspectives of people of African descent. Methods: The Black Genome Project is an …
“So We Create Happy Synergies” How An Overall Enabling Environment Helped Lao Pdr Legislate The Who Code On Breastmilk Substitutes: Lessons Learnt, Devina Buckshee
“So We Create Happy Synergies” How An Overall Enabling Environment Helped Lao Pdr Legislate The Who Code On Breastmilk Substitutes: Lessons Learnt, Devina Buckshee
Public Health Theses
ABSTRACT
Background: Exclusive breastfeeding rates in Lao People’s Democratic Republic (Lao PDR) remain at 44% against a global goal of at least 50%, partly due to a weak understanding of the multifactorial and multilevel determinants of breastfeeding (UNICEF, 2021). Therefore, evidence-based advocacy efforts call for a systems approach to improve the enabling environment around breastfeeding. Aim: This study aims to stitch together the comprehensive patchwork of actors and dynamic ‘gears’ in the socio-ecological environment that came together to develop a much more enabling environment to improve child nutrition through breastfeeding promotion and protection in Lao PDR. Further, it aims to …
Perceptions Of Hiv Pre-Exposure Prophylaxis And Correlates Of Interest Among Women At Shebeens In Rural South Africa, Arielle Kaminer Hazi
Perceptions Of Hiv Pre-Exposure Prophylaxis And Correlates Of Interest Among Women At Shebeens In Rural South Africa, Arielle Kaminer Hazi
Public Health Theses
Background: South Africa has the highest HIV burden in the world. In KwaZulu-Natal province, 27% of adults are living with HIV and 25% of new cases are in adolescent girls and young women. High prevalence of hazardous alcohol use complicates delivery of HIV testing, care, and prevention services. Gaps exist in knowledge on alcohol use among rural women and the association with HIV outcomes. We sought to understand facilitators and barriers to HIV pre-exposure prophylaxis (PrEP) initiation in women, focusing on local alcohol venues, called shebeens.Methods: Surveys and interviews conducted among women attending shebeens assessed alcohol use, HIV risk behaviors, …
A Dna-Extraction-Free Method For The Molecular Detection Of Streptococcus Pneumoniae Carriage In Saliva, Tzu-Yi Lin
A Dna-Extraction-Free Method For The Molecular Detection Of Streptococcus Pneumoniae Carriage In Saliva, Tzu-Yi Lin
Public Health Theses
Pneumococcal carriage is a prerequisite for pneumococcal disease and surveillance of carriage is crucial for evaluating and informing vaccination strategies. In recent years, molecular methods have improved the sensitivity of pneumococcal carriage detection as compared to the gold standard culture-based method. However, nucleic acid extraction from samples collected is resource-intensive, limiting scalability for extensive surveillance, particularly in low-resource settings. We previously developed a saliva-based PCR test for SARS-CoV-2, having identified that nucleic acid extraction can be omitted and replaced with a simple enzymatic lysis or heat treatment step without compromising the accuracy and efficiency of testing. Here, we compared pneumococcus …
Elucidating Metformin As A Scavenger Of 4-Hne, An Endogenously Produced Aldehyde Associated With Alzheimer’S Disease Progression, In Hek293t Cells, Miren Lopez Lascurain
Elucidating Metformin As A Scavenger Of 4-Hne, An Endogenously Produced Aldehyde Associated With Alzheimer’S Disease Progression, In Hek293t Cells, Miren Lopez Lascurain
Public Health Theses
Metformin, a first-line therapy for Type 2 Diabetes Mellitus (T2DM), has been shown to have numerous health benefits in neurodegenerative disease progressions, including Alzheimer’s disease (AD). Vasiliou et al. have recently proposed that metformin is able to scavenge endogenously produced aldehydes such as 4-hydroxy-2-nonenal (4-HNE), which are thought to contribute to the progression and development of AD. Preliminary in vitro and in silico studies demonstrate that metformin scavenges 4-HNE leading to adduct formation. Therefore, this study sought to determine if metformin adducts 4-HNE in a living system. We hypothesize that metformin can scavenge 4-HNE in HEK 293T cells and will …
"Hair-Esteem Toolkit For Black Girls": The Development Of A Self-Esteem Toolkit For Black Adolescent Girls Centering Hair As A Tool For Empowerment, Sydney Hussett-Richardson
"Hair-Esteem Toolkit For Black Girls": The Development Of A Self-Esteem Toolkit For Black Adolescent Girls Centering Hair As A Tool For Empowerment, Sydney Hussett-Richardson
Public Health Theses
Background: For Black adolescent girls, hair is a strong staple of gender and ethnic identity, influencing intrapersonal and interpersonal interactions. Gendered racism and Eurocentric beauty standards pathologize Black girls and their hair, leading them to experience high rates of hair harassment and discrimination. These experiences negatively impact the self-esteem of Black girls, which has important implications for a host of health behaviors. The purpose of this study was to explore the relationship between self-esteem and hair among Black girls and integrate findings into a culturally relevant digital toolkit to promote and develop hair-esteem and self-esteem among Black girls.Methods: This study …
The Ethical And Legal Considerations Of Ai-Driven Healthcare In Infectious Diseases, Natalie Makableh
The Ethical And Legal Considerations Of Ai-Driven Healthcare In Infectious Diseases, Natalie Makableh
Public Health Theses
Artificial intelligence (AI) has been rapidly growing in the healthcare sector, with the potential to improve patient outcomes, increase efficiency, and reduce costs. However, as with any technological advancement, AI-driven healthcare presents ethical and legal challenges that must be addressed to ensure the responsible and beneficial use of the technology. To the best of our knowledge this is the first study to examine the ethical and legal considerations of using AI technology in healthcare, with a particular focus on infectious diseases. With the growing use of AI in healthcare, it is crucial to evaluate its potential benefits and challenges in …
Variation In First-Line Therapy By Biomarker Expression Status In Patients With Advanced Non-Small Cell Lung Cancer, Yimeng Li
Public Health Theses
Background: Patients diagnosed with advanced non-small cell lung cancer (NSCLC) have a poor prognosis. To inform evidence-based care, this study aims to describe and quantify the first-line treatment variation of patients with NSCLC. Methods: A retrospective cohort study was conducted using Flatiron databases to analyze the treatment patterns of 18,979 patients with advanced NSCLC diagnosed between 1/1/2016 and 6/30/2020. Patients were categorized into groups by biomarker findings and performance status. The first-line treatment variations were measured using the Herfindahl-Hirschman Index (HHI), which provides an indication of the degree of variation in treatment. Bootstrapping was assisted in calculating 95% confidence intervals …