Digital Commons Network^™

The Immunology Of Inflammatory Bowel Disease, Hugh L. N. Mackechnie

Henry Ford Hospital Medical Journal

Although several measurements of both cellular and humoral immunity are altered in inflammatory bowel disease (IBD), no direct pathogenic role can be confirmed in either ulcerative colitis (UC) or Crohn's disease (CD). No clear role has been shown for allergic, microbiological, or psychogenic factors, and no specific genetic susceptibility has been demonstrated. Several studies have shown some benefit from using immunosuppressive drugs to treat inflammatory bowel disease, such as sulfasalazine to treat ulcerative colitis and corticosteroids to treat Crohn's disease. Whether these benefits derive from the anti-inflammatory activity of these drugs or from their immunological effects is uncertain.

Vaginal Colonization With Staphylococcus Aureus In Healthy Women: A Review Of Four Studies, Mary Guinan, Bruce B. Dan, Richard J. Guidotti, Arthur L. Reingold, George P. Schmid, Elena J. Bettoli, Joseph G. Lossick, Kathryn N. Shands, Mark A. Kramer, Nancy T. Hargrett, Roger L. Anderson, Claire V. Broome

School of Public Health Faculty Research

Four studies assessed the frequency of vaginal Staphylococcus aureus colonization in healthy women and associated risk factors. An association was found between S. aureus vaginal colonization and colonization at the labia minora and the anterior nares. Significant risk factors associated with an increased risk of vaginal S. aureus in at least one study were a history of genital herpes simplex infection, insertion of tampons without an applicator, and the use of Rely (Procter & Gamble) tampons. The use of systemic antibiotics within 2 weeks of the vaginal culture decreased the risk of recovery of S. aureus. The overall frequency …

Behcet's Syndrome: Case Report And Literature Review, K. V. Venkatasubramaniam, Douglas R. Swinehart

Henry Ford Hospital Medical Journal

Behcet's syndrome is a disease commonly found in Japan and in countries around the Mediterranean Sea. In the U.S., it is relatively uncommon. This report describes a 24-year-old Lebanese-American man with Behcet's syndrome who presented with symptoms four months after he developed arthritis and who had been initially diagnosed as having incomplete Reiter's syndrome. A literature review is Included.

1980 Beaumont Lecture: Restriction Enzymes As Tools For Genetic Research, Hamilton O. Smith

Henry Ford Hospital Medical Journal

No abstract provided.

Dissecting Aneurysm Of Aorta Complicating Coarctation Of The Aorta: Case Report And Brief Literature Review, Remigio Garcia, Julius M. Ohorodnik, Donald J. Magilligan Jr.

Henry Ford Hospital Medical Journal

The incidence of dissecting thoracic aorta aneurysm complicating coarctation of the aorta ranges from 1.7 to 23% in large series of coarctation of the aorta reported. In a review of 95 cases of dissection of the aorta, we found only one case with associated coarctation of the aorta. The presence of this anomaly, although rare, should be suspected and searched for in younger patients with dissection, in view of the surgical implications at the time of correction.

Geophysical Surveys For Buried Waste Detection At The Idaho National Engineering Laboratory, U.S. Department Of Energy

All U.S. Government Documents (Utah Regional Depository)

This report describes a series of geophysical surveys performed at the Idaho National Engineering Laboratory (INEL). The main purpose of the surveys was to evaluate techniques, principally ground-penetrating radar, for detecting and mapping radioactive wastes buried in shallow trenches and pits.

A Method Of Studying Leukocytic Functions In Vivo, John W. Rebuck, James H. Crowley

Henry Ford Hospital Medical Journal

No abstract provided.

A Method For Evaluating The Platelet Surface Response By Using Electron Microscopy, Jeanne M. Riddle

Henry Ford Hospital Medical Journal

Our method for evaluating the surface response of any given platelet population, which has evolved over the past two decades, provides a measure of both the adhesive and cohesive qualities of platelets. General morphologic features of the adherent, whole platelets can be assessed by transmission electron microscopy, and the results are reproducible when serial samples are collected on normal subjects and patient groups. With this technique, different metabolites and drugs can be combined with platelet populations that are either normoresponsive or hyperactive to determine if these substances trigger or inhibit the platelet response. To date, the results from in vitro …

Contributions Of Electron Microscopy To The Study Of Platelets, J. W. Rebuck, Jeanne M. Riddle, S. A. Johnson, R. W. Monto, Ruth M. Sturrock

Henry Ford Hospital Medical Journal

No abstract provided.

Functional And Biochemical Alterations Of Platelets In Atherosclerosis And Thromboembolism, Orhan N. Ulutin

Henry Ford Hospital Medical Journal

In atherosclerosis, platelets appear to circulate in an activated state. Our findings are based on results obtained from 240 patients. These platelets demonstrated an increased degree of surface activation and an increased amount of aggregation. Platelet aggregation was also demonstrated by a heightened sensitivity to adrenalin and ADP. Greater than normal secretion of ADP, PF-4, platelet fibrinogen, and platelet antiplasmin was noted. Platelet antiplasmin was increased, whereas platelet antithrombin III was decreased. Membrane transport of glucose was found to be defective in atherosclerosis. There appears to be no alteration in the phospholipid distribution, although the amount of phospholipids increases. The …

Percutaneous Transfemoral Renal Artery Occlusion In The Management Of Advanced Renal Carcinoma, Douglas E. Johnson

Henry Ford Hospital Medical Journal

This report describes renal artery occlusion as a therapeutic alternative to nephrectomy and chemotherapy in treating patients with metastatic renal carcinoma. Using a combination of Gelfoam and the Gianturco stainless steel coil, embolization was performed on 75 patients at the University of Texas System Cancer Center, M.D. Anderson Hospital and Tumor Institute with promising results. Its use is recommended 1) to facilitate surgical removal of large and difficult tumors, 2) to control local symptoms (pain, bleeding, etc), and 3) as part of a planned therapeutic program consisting of infarction, nephrectomy and progestins for patients with minimal to moderate metastatic disease.

Management Of Renal Cell Carcinoma: Evaluation Of Renal Masses By Modem Radiological Techniques, W. R. Eyler, M. A. Sandler, S. C. Cross, B. L. Madrazo

Henry Ford Hospital Medical Journal

The utilty of ultrasound and computed tomography is compared to angiography and that of nephrotomography in the study of renal masses. Ultrasound and computed tomography, noninvasive methods, are replacing nephrotomography and, in some cases, angiography

Isolation Of An Acid-Fast Organism From The Aqueous Humor In A Case Of Sarcoidosis, C. L. Barth, M. S. Judge, L. H. Mattman, P. C. Hessburg

Henry Ford Hospital Medical Journal

The anterior chamber fluid from the eye of this patient with sarcoidosis was found to contain microcolonies of a cellwall-deficient organism that was propagated and identified as acid-fast by the Intensified Acid-Fast stain. The colonies were inoculated into mice and retrieved from the dead or sacrificed animals. This report suggests that the acid-fast microbe in the aqueous humor of this case of uveitis-sarcoidosis may be the same organism as that found in the blood in sarcoidosis. Thus, it may be associated not only with the primary disease, but also with the complications of Boeck's sarcoidosis.

1978 Publications Of The Staff Of Henry Ford Hospital

Henry Ford Hospital Medical Journal

No abstract provided.

Commencement Program 1979, Loma Linda University

Commencement Programs

CONTENTS

2 | 1979 Events of Commencement

3 | Conferring of Degrees

7 | Candidates for Degrees

26 | Awards

27 | Academic Costume

Indian Health Service Phoenix Area Tribal Involvement Evaluation Project., Indian Health Service Phoenix Area

Native Health Database Full Text

Report from the Indian Health Service Phoenix Area Tribal Involvement Evaluation Project.

In Vitro And Clinical Studies Of Cefaclor, A New Cephalosporin, Daria Kiani, Tom Madhavan, Keith Burch, Don Pohlod, Evelyn Fisher, Edward L. Quinn

Henry Ford Hospital Medical Journal

In vitro susceptibility studies of 246 clinical isolates demonstrated that this antibiotic was effective against Group A beta hemolytic streptococci, alpha hemolytic streptococci, S. pneumoniae, both penicillinase producing and nonpenicillinase producing Staphylococci, Klebsiella pneumoniae, and Proteus mirabilis. Cephalothin susceptible E. coii were also susceptible to cefaclor. Pseudomonas aeruginosa, Serratia sp., Enterobacter Sp., and Streptococcus faecalis were uniformly resistant to cefaclor. The efficacy and safety of this antibiotic were studied in 27 patients with urinary tract, soft tissue, and respiratory infections. Patients with urinary tract infections became abacteriuric after 48 hours. Patients with soft tissue infections responded well within the first …

A Comparison Of Two Instructional Methods In Teaching An Introductory Course In Health, Charlotte Mitchell

Masters Theses & Specialist Projects

The purpose of this research was to determine the effectiveness of the independent study method of instruction in promoting health knowledge and health attitude change. The experimental method was compared to the traditional classroom model of instruction.

A random sample of ten subjects was taken for the experimental group and matched control subjects were then selected. Control subjects were chosen based on the demographic variables of age, race, sex, academic classification and grade point average.

A pretest-posttest design using two standardized instruments was employed to measure the health knowledge gain and health attitude change. Data was statistically analyzed by use …

A Comparison Of Kidney Preservation Methods By Oxidative Phosphorylation Studies, Devprakash Samuel, Stanley G. Dienst

Henry Ford Hospital Medical Journal

An oxygen consumption assay using adenosine diphosphonucleotide (ADP) was performed on canine kidneys to measure the efficiency of oxidative phosphorylation. The purpose of the assay was to establish a respiratory control index (RCI) that could be used to evaluate kidneys preserved by different methods. Of the four methods tested, perfusion yielded the best results after 24-hour preservation. Additionally, four pairs of human cadaver kidneys were evaluated with the same assay. Some correlation existed between the RCI values of the nontransplanted kidney in each pair and the clinical viability of its transplanted mate.

Commencement Program 1978, Loma Linda University

Commencement Programs

CONTENTS

2 | 1978 Events of Commencement

3 | Conferring of Degrees

7 | Candidates for Degrees

26 | Awards

28 | Academic Costume

Studies On Uveitis Part Ii: Hypotheses With Case Reports, Philip C. Hessburg

Henry Ford Hospital Medical Journal

A number of patients with and without uveitis are used to show that this study of aqueous microbiology suggests the following hypotheses: 1. Routine techniques currently used in most microbiology laboratories overlook classical and variant bacteria which might be isolated from clinical specimens with improved microbiological techniques. 2. Bacterial forms may be present in other ocular tissue when not present in the aqueous. 3. Polymicrobial infections probably occur rather frequently, especially in chronic or subacute inflammatory states. 4. Alterations in various host factors may subject some persons to a greater incidence of inflammatory episodes including uveitis. 5. Antibiotics used in …

The Quantitative Determination Of 3-Oxo-Bile Acids, W. T. Beher, G. J. Lin, J. Sanfield, S. Stradnieks

Henry Ford Hospital Medical Journal

A new method for the rapid quantification of 3-oxo-bile acids has been developed. From 5 to 120 μg of oxo-acid in aqueous or ethanolic media are reduced with sodium borohydride. The resulting 3α- and 3β-hydroxy acids are then oxidized in a reaction catalyzed by 3-hydroxysteroid dehydrogenase, during which nicotinamide adenine dinucleotide (NAD) is reduced to NADH. The absorbance of the reaction mixture is determined at 340 nm and is directly proportional to the amount of 3-oxo-acid in the original sample. The method is fully compatible with that used in determining 3α-hydroxy-bile acids.

A Pilot Study Of A Sex Education Program In A Sheltered Workshop Using A Cognitive-Behavioral Model Based On Rational Emotive Therapy, Jacqueline A. Rieck, Thomas E. Frederick

Masters Theses

This pilot study was developed to teach people with mental retardation about their own sexuality, appropriate community behaviors, and to develop within them a basic sense of responsibility for their own actions. Problems in social/sexual behaviors have been consistently quoted as reasons for high recidivism rates, as well as difficulties in community living, vocational placement, and other generalized stereotypes about mental retardation. Often the public remains uninformed about, does not recognize, and/or feels that sexual rights for people with any mental differences should not exist. Additionally, when any form of sexuality was expressed by such people it resulted in shock …

Studies On Uveitis Part I: Aqueous Studies, Philip C. Hessburg

Henry Ford Hospital Medical Journal

Aqueous microbiological and cytological studies were performed on 134 anterior chamber taps done on 118 patients both with and without uveitis. Cell wall defective bacterial forms (CWDF) were recovered from about 40% of these aqueous specimens and classical bacteria were recovered from 12%. A statistically significant difference could not be found between the incidence of bacterial cell wall defective forms in the various anatomical types of uveitis. There were hints from this work that the presence of CWDF In the aqueous was more frequent in younger patients with uveitis, early in the uveitis attack, if there were multiple foci of …

The Water-Soluble Contrast Medium Lumbar Myelogram And Its Surgical Correlations, Henri C. Labasse

Henry Ford Hospital Medical Journal

The water-soluble contrast medium lumbar myelogram is a very helpful tool in the diagnosis of herniated nucleus pulposus (EfNP) in patients who suffer unilateral root pain of mechanical course. One can often make the differential diagnosis between a ruptured disc and a protruding disc. Unless the disc fragment lies way out in the intervertebral foramen, the myelogram will show some kind of anomaly. Therefore, fewer exploratory operations will be performed on patients having normal myelograms. Metrisamide, a newcomer among the water-soluble contrast media, is nontoxic for the spinal cord. Therefore, if the usual myelogram is normal and one fears a …

Selective Cerebral Arteriography And The Cat Scan In Acoustic Tumors, Donald C. Austin

Henry Ford Hospital Medical Journal

Increasing experience with selective cerebral arteriography in the diagnostic evaluation of acoustic tumors has led to a more rational determination of the proper surgical approach to the lesion. It also predicts the necessity for staging the surgical procedure, reduces the potential for intraoperative complications and rules out other types of angle lesions and the possible necessity for performing a preoperative, concomitant or postoperative shunting procedure. The CAT scan has added an important screening procedure in predicting the presence of an angle lesion, determining the need for further diagnostic studies and evaluating the possible presence or absence of a recurrent tumor …

Commencement Program 1977, Loma Linda University

Commencement Programs

CONTENTS

2 | 1977 Events of Commencement

3 | Conferring of Degrees

7 | Candidates for Degrees

25 | Awards

27 | Academic Costume

Susceptibility At High Inoculum Of Penicillin-Resistant Staphylococcus Aureus To Six Cephalosporins, Andres Suarez, Ramon Del Busto, Edward L. Quinn, Donald Pohlod

Henry Ford Hospital Medical Journal

Six cephalosporins (currently available for clinical use or undergoing clinical trials) were tested by tube dilution method against high inoculum (10⁷ colony forming units) of 37 strains of penicillin resistant Staphylococcus aureus. 3.1 μg/ml of cephalothin inhibited 100% of strains while higher concentrations of cefoxitin, cephapirin, cefamandole, cephalexin and cephradine were required. The percent of strains with minimal inhibitory concentration higher than 3.1 μg/ml ranged between 10.8% (cefoxitin) and 100% (cephradine). These findings support the observation that cephalothin is less susceptible to inactivation than the other cephalosporins. Although the exact clinical implication of these findings has not been established, …

Prolonging Oxygen Consumption During Preservation Of Canine Kidneys By The Addition Of Continuous Dialysis, Daniel Dall'olmo, Stanley G. Dienst

Henry Ford Hospital Medical Journal

Kidneys were preserved by continuous pulsatile perfusion and their metabolic rate monitored by O2 consumption. Experiments were carried out to determine if dialyzing the perfusate to supply metabolic substrates would aid in kidney preservation. A control group was compared against two experimental groups at 25°C. Average preservation time before fall off of oxygen consumption differed for each group: control - 8 hours, dialysis with amino acids - 6 hours, dialysis with amino acids and cofactors - 11 hours. Results indicated that, if suitable concentrations of metabolic substrates and cofactors were used, the preserved kidneys maintained higher levels of O2 consumption …

Oral Contraceptives And Myocardial Infarction: Report Of Three Cases And Review Of The Literature, Mohsin Alam, Remigio Garcia, Ellet H. Drake

Henry Ford Hospital Medical Journal

Three cases are presented of young women who had myocardial infarctions possibly due to coronary thrombosis related to oral contraceptive therapy. These patients had none or very few risk factors for coronary artery disease. In two of the patients, selective coronary arteriograms showed normal results on the third and tenth week after the diagnosis was established. The pathogenesis of coronary artery thrombosis in patients receiving oral contraceptives containing estrogen is still controversial, but it appears to be the result of its multifactorial effect on the platelets, coagulation factors, vessel wall, blood pressure, postprandial blood sugar and abnormalities of lipid metabolism.