Digital Commons Network^™

The Current Youth Sport Culture And Its Impact On Sport Participation Experiences Of Low Socioeconomic Status Families, Mayrena I. Hernandez, Elena C. Miller, Laura A. Prieto, Luis Columna, Kevin M. Biese, David R. Bell

Internet Journal of Allied Health Sciences and Practice

Purpose: The rise of sport specialization can jeopardize the opportunities for families of low socioeconomic status (SES) to participate in organized sport. However, obtaining an athletic scholarship may be a motivating factor for low SES youth to sport specialize. Yet, the experiences of low SES athletes in sport participation are not well known. Method: We used an Interpretative phenomenological analysis (IPA) to explore experiences of low SES families with children participating in sport and how this may be impacted by the current youth sport culture that promotes sport specialization. We engaged in semi-structured interviews with 12 low SES parents. Results: …

Ad-Syn-Net: Systematic Identification Of Alzheimer's Disease-Associated Mutation And Co-Mutation Vulnerabilities Via Deep Learning, Xingxin Pan, Zeynep H Coban Akdemir, Ruixuan Gao, Xiaoqian Jiang, Gloria M Sheynkman, Erxi Wu, Jason H Huang, Nidhi Sahni, S Stephen Yi

Faculty, Staff and Student Publications

Alzheimer's disease (AD) is one of the most challenging neurodegenerative diseases because of its complicated and progressive mechanisms, and multiple risk factors. Increasing research evidence demonstrates that genetics may be a key factor responsible for the occurrence of the disease. Although previous reports identified quite a few AD-associated genes, they were mostly limited owing to patient sample size and selection bias. There is a lack of comprehensive research aimed to identify AD-associated risk mutations systematically. to address this challenge, we hereby construct a large-scale AD mutation and co-mutation framework ('AD-Syn-Net'), and propose deep learning models named Deep-SMCI and Deep-CMCI configured …

Sources Of Stress, Burnout, And Career Decisions Of Male Health And Nursing Professionals: A Qualitative Inquiry Of The Challenges During The Covid-19 Pandemic, Luis Miguel Dos Santos

The Qualitative Report

The human resources and workforce shortage of registered health and nursing professionals has been a long-term problem in health systems internationally, particularly during the COVID-19 pandemic. Many health and nursing professionals face stress and burnout, which may influence their career decisions and long-term human resources development. The purpose of this study is to investigate and understand the relationship(s) between sources of stress and the reasons why male health and nursing professionals decide to leave the profession within the next six months. With the employment of the social cognitive career and motivation theory and general inductive approach with 40 male health …

Pemodelan Statistik Hubungan Antara Persalinan Sesar Dengan Inisiasi Menyusu Dini Di Provinsi Dki Jakarta (Analisis Data Sdki 2017), Amanda Widlanisia, Kemal N. Siregar

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Pemberian ASI merupakan usaha dan investasi yang mudah dilakukan untuk menekan angka morbiditas dan mortalitas pada bayi dan anak. Keterlambatan pemberian ASI pertama dapat diakibatkan oleh metode kelahiran yang dipilih seperti secara pervaginam atau persalinan sesar. Penelitian ini dilakukan secara cross sectional dan pendekatan kuantitatif menggunakan data SDKI 2017 untuk mengetahui hubungan antara persalinan sesar dengan Inisiasi Menyusu Dini (IMD) di Provinsi DKI Jakarta. Sampel yang digunakan adalah wanita usia subur 15-49 tahun saat survei di Provinsi DKI Jakarta yang memiliki anak terakhir yang lahir dalam 2 tahun terakhir sebanyak 236 responden. Dilakukan analisis statistik univariat, bivariat menggunakan chi-square (CI …

Gambaran Kematian Maternal Di Kota Depok Sebelum Dan Sesudah Pandemi Covid-19, Dhora Yufita, Milla Herdayati

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Pandemi COVID-19 menimbulkan tantangan baru bagi kematian ibu yang berdampak pada seluruh aspek. Kematian ibu perlu menjadi perhatian khusus dikarenakan Angka Kematian Ibu (AKI) merupakan salah satu indikator yang menggambarkan kesejahteraan suatu bangsa. Tujuan penelitian ini adalah untuk mengetahui gambaran kematian ibu sebelum dan setelah pandemi COVID-19 di Kota Depok. Penelitian ini merupakan penelitian deskriptif kuantitatif yang menggambarkan isi suatu variabel dalam penelitian dan tidak dimaksudkan untuk menguji hipotesis tertentu. Hasil penelitian didapatkan bahwa kematian ibu di Kota Depok terbanyak terjadi pada tahun 2021 dengan jumlah kematian 65 kasus, dan penyebab tertinggi adalah COVID-19. Tingginya kematian ibu akibat COVID-19 dikarenakan …

Faktor-Faktor Terjadinya Kematian Neonatal Di Indonesia: Analisis Data Sdki 2017, Mochtar Ghaffar Ramadhan, Ulya Qoulan Karima, Terry Yuliana, Chahya Kharin Herbawani

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Kematian neonatal merupakan masalah yang harus diselesaikan dalam SDGs. Sama halnya di Indonesia, masih adanya ketimpangan antara target RPJMN 2020-2024 untuk menurunkan angka kematian neonatal menjadi 10 per 1000 kelahiran hidup. Penelitian ini bertujuan untuk mengetahui faktor-faktor terjadinya kematian neonatal di Indonesia sebagai salah satu cara untuk mencapai target RPJMN. Penelitian ini menggunakan desain studi potong lintang dengan analisis data sekunder SDKI 2017. Sampel yang digunakan penelitian ini adalah 34.972 wanita usia subur usia 15-49 tahun yang pernah melahirkan di Indonesia. Analisis menggunakan pembobotan dan analisis yang digunakan adalah analisis spasial, Chi-Square, dan regresi logistik ganda. Hasil analisis bivariat menunjukkan …

Pengelompokan Provinsi Di Indonesia Berdasarkan Faktor Risiko Perilaku Penyakit Tidak Menular Dengan Metric Multidimensional Scaling, Syafira Maulidia, Rahmi Susanti, Ismail Ab

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Angka kasus penyakit tidak menular (PTM) di Indonesia terus mengalami peningkatan. Faktor pendorong utama terjadinya peningkatan PTM adalah dari faktor risiko perilaku yaitu, pengunaan tembakau, penggunaan alkohol, aktivitas fisik, dan diet tidak sehat. Berdasarkan hal tersebut diperlukan pengelompokan provinsi di Indonesia berdasarkan faktor risiko perilaku PTM. Menghasilkan kelompok-kelompok provinsi di Indonesia berdasarkan faktor risiko perilaku PTM. Jenis penelitian ini adalah non-reactive research. Pengelompokan provinsi di Indonesia menggunakan analisis Metric Multidimensional Scaling dan analisis One Way MANOVA sebagai analisis lanjutan untuk memvalidasi perbedaan kelompok yang dibentuk. Data yang digunakan merupakan data sekunder dari publikasi laporan Riset Kesehatan Dasar Indonesia tahun …

Global Scientific Trends On Healthy Eating From 2002 To 2021: A Bibliometric And Visualized Analysis, Te Fang, Hongyi Cao, Yue Wang, Yang Gong, Zhongqing Wang

Faculty, Staff and Student Publications

Diet has been recognized as a vital risk factor for non-communicable diseases (NCDs), climate changes, and increasing population, which has been reflected by a rapidly growing body of the literature related to healthy eating. To reveal a panorama of the topics related to healthy eating, this study aimed to characterize and visualize the knowledge structure, hotspots, and trends in this field over the past two decades through bibliometric analyses. Publications related to healthy eating between 1 January 2002 and 31 December 2021 were retrieved and extracted from the Web of Science database. The characteristics of articles including publication years, journals, …

A Scoping Review Of Digital Health Interventions For Combating Covid-19 Misinformation And Disinformation, Katarzyna Czerniak, Raji Pillai, Abhi Parmar, Kavita Ramnath, Joseph Krocker, Sahiti Myneni

Faculty, Staff and Student Publications

OBJECTIVE: We provide a scoping review of Digital Health Interventions (DHIs) that mitigate COVID-19 misinformation and disinformation seeding and spread.

MATERIALS AND METHODS: We applied our search protocol to PubMed, PsychINFO, and Web of Science to screen 1666 articles. The 17 articles included in this paper are experimental and interventional studies that developed and tested public consumer-facing DHIs. We examined these DHIs to understand digital features, incorporation of theory, the role of healthcare professionals, end-user experience, and implementation issues.

RESULTS: The majority of studies (n = 11) used social media in DHIs, but there was a lack of platform-agnostic generalizability. …

Innovative Research Framework For Strengthening Health Care And Public Health Engagement In Neighborhood Change As A Social Determinant Of Health, Christopher Williams, Nathaniel Woodard, Charlene Chao-Li Kuo

Advances in Clinical Medical Research and Healthcare Delivery

Background

Neighborhood change is a social determinant of health (SDOH) that has been associated with adverse health and increased health care utilization. The number of cities and neighborhoods undergoing intense gentrification, defined as an influx of wealthy populations into a working-class neighborhood, is not highly numerous. Public health and health systems are increasingly engaged with SDOH in community-level interventions. Pathways to study and affect NC-related health impacts are limited. This unfunded study provides a research framework to address concerns about financial investment, identifying population health needs, and community stakeholder engagement.

Methods

The authors conducted a cross-sectional pilot study in a …

The P323l Substitution In The Sars-Cov-2 Polymerase (Nsp12) Confers A Selective Advantage During Infection, Hannah Goldswain, Xiaofeng Dong, Rebekah Penrice-Randal, Muhannad Alruwaili, Ghada T Shawli, Tessa Prince, Maia Kavanagh Williamson, Jayna Raghwani, Nadine Randle, Benjamin Jones, I'Ah Donovan-Banfield, Francisco J Salguero, Julia A Tree, Yper Hall, Catherine Hartley, Maximilian Erdmann, James Bazire, Tuksin Jearanaiwitayakul, Malcolm G Semple, Peter J M Openshaw, J Kenneth Baillie, Isaric4c Investigators, Stevan R Emmett, Paul Digard, David A Matthews, Lance Turtle, Alistair C Darby, Andrew D Davidson, Miles W Carroll, Julian A Hiscox

Faculty, Staff and Student Publications

BACKGROUND: The mutational landscape of SARS-CoV-2 varies at the dominant viral genome sequence and minor genomic variant population. During the COVID-19 pandemic, an early substitution in the genome was the D614G change in the spike protein, associated with an increase in transmissibility. Genomes with D614G are accompanied by a P323L substitution in the viral polymerase (NSP12). However, P323L is not thought to be under strong selective pressure.

RESULTS: Investigation of P323L/D614G substitutions in the population shows rapid emergence during the containment phase and early surge phase during the first wave. These substitutions emerge from minor genomic variants which become dominant …

Syndemics And Social Factors: Infectious Disease Patterns Within The Population Of People Experiencing Homelessness In The United States, Kathleen Berzonsky

Honors Program: Senior Projects (Public)

Individuals experiencing homelessness are at increased risk of suffering from infectious diseases. This is due to a number of social factors and healthcare disparities, as well as the idea of syndemics, by which diseases cluster together to worsen disease burden. Current intervention strategies approach treatment from a post-infection perspective, but reducing transmission rates of infectious diseases within the population of people experiencing homelessness will require a shift in the healthcare framework. The issue of people experiencing homelessness must be viewed through a biosocial lens, focusing on preventative care and treatment. I provide an overview of the social factors governing infectious …

Hiv Stalks Bodies Like Mine: An Autoethnography Of Self-Disclosure, Stigmatized Identity, And (In)Visibility In Queer Lived Experience, Steven Ryder

USF Tampa Graduate Theses and Dissertations

This dissertation examines self-disclosure of Human Immunodeficiency Virus (HIV) status within the context of communication between long-standing friends. For the purposes of my study, I define this type of friendship as those who have known me for at least two years and with whom I communicate regularly. These are friends who tend to know a variety of personal details about me, ranging from superficial to private and trivial to essential. I use autoethnography to ground the study in my lived experience. By doing so, I present intimate accounts of my communication with others across my lifespan to function as background …

Factors Impacting Readiness To Perform Secondary Population-Based Triage During The Second Wave Of Covid-19 In Victoria, Australia: Pilot Study, Zachary B. Horn

Research outputs 2022 to 2026

Objective: Pandemics generate such a significant demand for care that traditional triage methods can become saturated. Secondary population-based triage (S-PBT) overcomes this limitation. Although the coronavirus disease (COVID-19) pandemic forced S-PBT into operation internationally during the first year of the pandemic, Australian doctors were spared this responsibility. However, the second wave of COVID-19 provides an opportunity to explore the lived experience of preparing for S-PBT within the Australian context. The aim of this study is to explore the lived experience of preparing to operationalize S-PBT to allocate critical care resources during Australia's second wave of COVID-19 in 2020. Methods: Intensivists …

Engaging Youth In The Development, Implementation, An Evaluation Of Sexual And Reproductive Health Programs, Pam Drake, Kristin Kennedy

National Youth Advocacy & Resilience Conference

This session will introduce the use of a group concept mapping process to create a conceptual model for engaging youth in sexual and reproductive health programming – particularly BIPOC LGBTQ+ youth and young men of color. We will walk through the gcm process, present the model, and explore ways to apply the model in various situations.

Sustainable Management Of Facemask Waste Generated From Covid-19 Pandemic In Bhutan, Tshering Yangdon, Twisuk Punpeng, Sirima Mongkolosomit, Kampol Nanthapong, Kinzang Yangden

Journal of Health Research

Background: The rise in facemask waste with the uncertainty of deposition data and all its concomitant pressure on management has resulted in new risks and challenges for achieving sustainable development goals (SDGs). The purpose of this mixed methods study was to estimate facemask waste generation and examine management in Bhutan since the COVID-19 pandemic.

Method: One thousand five hundred and twenty-seventh (1,527) consenting members of the public from Class A Thromdes (self-governing municipalities) were surveyed online from February to April 2022, to estimate mask waste using descriptive statistics. This was supported by the waste characterization conducted in Memelhakha, the biggest …

Workers' Perceptions On The Tolerability Of Their Respirators In Malaysia, Muhammad Z. Yusof, Nor I. Mukhtar

Journal of Health Research

Background: Little is known about Malaysian workers' tolerance for respirators in the workplace. This study aimed to assess Malaysian workers' perceptions of respirator tolerability and its relationship to socio-demographics and compliance.

Method : This cross-sectional study was conducted between October and December 2021 among respirator users in the agricultural, industrial, and service sectors. Background information and respirator compliance were collected using a structured online questionnaire. A R-COMFI questionnaire was used to measure respirator tolerability.

Results: This study recruited 340 participants, but only 278 of them met the inclusion criteria. More than half reported that wearing respirators was uncomfortable, impacted focus, …

Determinants Of Child Stunting, Wasting, And Underweight: Evidence From 2017 To 2018 Pakistan Demographic And Health Survey, Maryam Siddiqa, Gulzar H. Shah, Tilicia Mayo-Gamble, Amber Zubair

Health Policy & Community Health: Faculty Publications

Child malnutrition persists in low-resource countries such as Pakistan, indicating an urgent need for interventions and policies aimed to address this critical population health issue. The World Health Organization Global Target 2025 includes the reduction of malnourishment in the form of stunting, wasting, and low weight. This study aims to examine the prevalence of factors associated with three measures of child malnutrition, i.e., stunting, wasting, and low weight in Pakistan. This study uses a secondary data analysis design based on data from Pakistan Demographic and Health Survey (2017-18) that used a two-stage cluster sampling approach. National level data covering urban …

Adolescent Pregnancy Prevention: How Cultural Components Play A Role In Programs Tailored For Minority Youth, Sarah B. Maness, Shristi Bhochhibhoya, Marshall Cheney

Journal of Health Disparities Research and Practice

Introduction: Cultural tailoring of adolescent pregnancy prevention programs has been utilized as a way to reduce persisting racial and ethnic disparities. This study explored how cultural components are included in evidence-based adolescent pregnancy prevention programs.

Methods: This study qualitatively assessed curricula of six federally supported evidence-based adolescent pregnancy prevention programs specifically tailored for African American and/or Hispanic youth. Patterns were analyzed within and between programs by two independent coders.

Results: Cultural components fell into five major themes: cultural art forms, traditions, history, community, and language. The most commonly included area was traditions (i.e. values, pride).

Conclusions: Variations exist in …

Factors Influencing The Use Of Multiple Hiv Prevention Services Among Transport Workers In A City In Southwestern Uganda, Benjamin Betunga, Phionah Atuhaire, Catherine Nakasiita, Christa Kanyamuneza, Proscovia Namiiro, Joseph Tugume, Matovu Hairat, Ahmed Sarki, Benedicto Mugabi, Birungi Lilian, Richard Mugisha Richard Mugisha, Edward Kumakech, John Baptist Asiimwe

School of Nursing & Midwifery, East Africa

The use of multiple HIV prevention services has been found to decrease the risk of acquiring HIV when tailored to individuals at risk of HIV exposure, including transport workers. Therefore, we assessed the uptake of multiple HIV prevention services (≥2) and associated factors among transport workers in a city in Southwestern Uganda. This cross-sectional study comprised motorcycle taxi riders, motor vehicle and truck drivers, aged 18 to 55 years who were selected and responded to an interviewer-administered questionnaire, between November 2021 and February 2022. Data was analyzed using descriptive statistical and modified Poisson regression analyses. Out of 420 participants, 97.6% …

Hpv Vaccination And Cervical Cancer Screening Promotion Among Black Individuals: Social Ecological Perspectives From Key Informants Interviews, Adebola Adegboyega, Desmennu Adeyimika, Obielodan Omoadoni, Dignan Mark

UK CARES Faculty Publications

Objectives: Rates of HPV infection and HPV-related cancers are elevated in the Black population of the US. Efforts to promote HPV vaccination and cervical cancer screening are important to reducing the cancer burden among Black populations. The purpose of this qualitative descriptive study guided by social ecological model (SEM) was to describe from the perspective of key informants, the challenges and opportunities for HPV vaccination and cervical cancer screening promotion among Black adults.

Design: Twenty-three key informants participated in individual interviews over zoom video conferencing. The sessions were audio- recorded, transcribed verbatim, and checked for accuracy prior to data analysis. …

The Policy Environment Of Self-Care: A Case Study Of The Philippines, Leonardo Jaminola Iii, Jana Marie Negre, Veincent Christian F. Pepito, Arianna Maever Loreche, Manuel M. Dayrit

Ateneo School of Medicine and Public Health Publications

Self-care is the ability and empowerment of individuals to maintain health through informed health-care decisions, with or without the support of a health provider. High-income countries have made advances to their conceptualization, research and institutionalization of self-care, given its reported benefits to patients, the health system and economy. A similar undertaking in low- and middle-income countries (LMICs) with already fragile health systems is warranted as highlighted by the coronavirus disease 2019 pandemic. Our article therefore aimed to describe and analyse the policy environment of self-care using the Philippines as a case study, which may have relevance to other similar countries …

“High” Innovators? Marijuana Legalization And Regional Innovation, Stephanie Cheng, Pengkai Lin, Yinliang Tan, Yuchen Zhang

Research Collection School Of Accountancy

The past three decades have witnessed a tremendous shift in public health policies towards marijuana legalization in the U.S. Adopting the process-based view of innovation, we hypothesize that marijuana's increased use and related consequences after its legalization affect innovators’ behavior and social environment during the innovation process, which in turn impacts regional innovation. Utilizing the staggered adoption of medical marijuana laws by 20 states between 1996 and 2013 as a quasi-experimental setting, we find that legalizing medical marijuana reduces the overall output of regional innovation, as proxied by patents’ total forward-citation count aggregated by innovator location. Further analyses decomposing the …

Subjective Versus Objective Sleep Outcomes In Older Adults With And Without Uncoupled Sleep Following Online Cognitive Behavioural Therapy For Insomnia, Yvonne Kutzer, Lisa Whitehead, Eimear Quigley, Shih Ching Fu, Mandy Stanley

Research outputs 2022 to 2026

Background: Uncoupled sleep is a phenomenon characterised by a disconnect between sleep pattern and sleep complaint. This study examined the impact of uncoupled sleep on dysfunctional sleep beliefs and objective and subjective sleep outcomes in community-dwelling older adults following digitally delivered Cognitive Behavioural Therapy for Insomnia (CBT-I) to assess how these groups respond to CBT-I. Methods: Objective sleep was measured using wrist actigraphy, subjective sleep quality via sleep diaries and the Pittsburgh Sleep Quality Index (PSQI). Dysfunctional sleep beliefs were assessed by the Dysfunctional Beliefs and Attitudes about Sleep scale (DBAS-16). All measurements were taken prior to and following a …

The Investigation Of Health-Related Topics On Tiktok: A Descriptive Study Protocol, Joelie Mandzufas, Jeremiah Ayalde, Daniel Ta, Emily Munro, Rigel Paciente, Emmanuel P. Pranoto, Kaelyn King, Kelly How, Alanna Sincovich, Mary Brushe, Nicole Wickens, Gabriella Wells, Alix Woolard, Melinda Edmunds, Hannah Thomas, Gina S. A. Trapp, Karen Lombardi

Research outputs 2022 to 2026

The social media application TikTok allows users to view and upload short-form videos. Recent evidence suggests it has significant potential for both industry and health promoters to influence public health behaviours. This protocol describes a standardised, replicable process for investigations that can be tailored to various areas of research interest, allowing comparison of content and features across public health topics. The first 50 appearing videos in each of five relevant hashtags are sampled for analysis. Utilising a codebook with detailed definitions, engagement metadata and content variables applicable to any content area is captured, including an assessment of the video’s overall …

In Utero Exposure To Antiemetic And Risk Of Adult-Onset Colorectal Cancer, Caitlin C Murphy, Piera M Cirillo, Nickilou Y Krigbaum, Amit G Singal, Barbara A Cohn

Faculty, Staff and Student Publications

BACKGROUND: Incidence rates of colorectal cancer (CRC) are increasing among adults born in and after the 1960s, implicating pregnancy-related exposures introduced at that time as risk factors. Dicyclomine, an antispasmodic used to treat irritable bowel syndrome, was initially included in Bendectin (comprising doxylamine, pyridoxine, and dicyclomine), an antiemetic prescribed during pregnancy in the 1960s.

METHODS: We estimated the association between in utero exposure to Bendectin and risk of CRC in offspring of the Child Health and Development Studies, a multigenerational cohort that enrolled pregnant women in Oakland, CA, between 1959 and 1966 (n = 14 507 mothers and 18 751 …

Alzheimer's Disease Genetic Risk, Cognition, And Brain Aging In Midlife, Willa D Brenowitz, Myriam Fornage, Lenore J Launer, Mohamad Habes, Christos Davatzikos, Kristine Yaffe

Faculty, Staff and Student Publications

We examined associations of an AD genetic risk score (AD-GRS) and midlife cognitive and neuroimaging outcomes in 1,252 middle-aged participants (311 with brain MRI). A higher AD-GRS based on 25 previously identified loci (excluding APOE) was associated with worse Montreal Cognitive Assessment (−0.14 SD[95% CI:−0.26,−0.02]), older machine learning predicted brain age (2.35 years[95%CI:0.01,4.69]), and white matter hyperintensity volume (0.35 SD [95% CI:0.00,0.71), but not with a composite cognitive outcome, total brain, or hippocampal volume. APOE ε4 allele was not associated with any outcomes. AD risk genes beyond APOE may contribute to subclinical differences in cognition and brain health in …

Metabolomic Markers Of Ultra-Processed Food And Incident Ckd, Donghan Su, Jingsha Chen, Shutong Du, Hyunju Kim, Bing Yu, Kari E Wong, Eric Boerwinkle, Casey M Rebholz

Faculty, Staff and Student Publications

BACKGROUND: High ultra-processed food consumption is associated with higher risk of CKD. However, there is no biomarker for ultra-processed food, and the mechanism through which ultra-processed food is associated with CKD is not clear. Metabolomics can provide objective biomarkers of ultra-processed food and provide important insights into the mechanisms by which ultra-processed food is associated with risk of incident CKD. Our objective was to identify serum metabolites associated with ultra-processed food consumption and investigate whether ultra-processed food-associated metabolites are prospectively associated with incident CKD.

METHODS: We used data from 3751 Black and White men and women (aged 45-64 years) in …

Global Epidemiology And Clinical Outcomes Of Carbapenem-Resistant Pseudomonas Aeruginosa And Associated Carbapenemases (Pop): A Prospective Cohort Study, Jinnethe Reyes, Lauren Komarow, Liang Chen, Lizhao Ge, Blake M Hanson, Eric Cober, Erica Herc, Thamer Alenazi, Keith S Kaye, Julia Garcia-Diaz, Lanjuan Li, Souha S Kanj, Zhengyin Liu, Jose M Oñate, Robert A Salata, Kalisvar Marimuthu, Hainv Gao, Zhiyong Zong, Sandra L Valderrama-Beltrán, Yunsong Yu, Paul Tambyah, Gregory Weston, Soraya Salcedo, Lillian M Abbo, Qing Xie, Karen Ordoñez, Minggui Wang, Martin E Stryjewski, Jose M Munita, David L Paterson, Scott Evans, Carol Hill, Keri Baum, Robert A Bonomo, Barry N Kreiswirth, Maria Virginia Villegas, Robin Patel, Cesar A Arias, Henry F Chambers, Vance G Fowler, Yohei Doi, David Van Duin, Michael J Satlin

Faculty, Staff and Student Publications

Background: Carbapenem-resistant Pseudomonas aeruginosa (CRPA) is a global threat, but the distribution and clinical significance of carbapenemases are unclear. The aim of this study was to define characteristics and outcomes of CRPA infections and the global frequency and clinical impact of carbapenemases harboured by CRPA.

Methods: We conducted an observational, prospective cohort study of CRPA isolated from bloodstream, respiratory, urine, or wound cultures of patients at 44 hospitals (10 countries) between Dec 1, 2018, and Nov 30, 2019. Clinical data were abstracted from health records and CRPA isolates were whole-genome sequenced. The primary outcome was 30-day mortality from the day …

Effects Of Occupationally Military-Relevant Particle Mixtures (Sio2, Cdo, Cr2O3) On A549 Human Pulmonary Epithelial Cells, Isabella M. Muffoletto

Theses and Dissertations

In the course of maintaining a safe, mission-ready aircraft fleet and operational runways, United States Airmen experience a range of occupational risks. These risks include inhalable hazards generated from oft-used maintenance practices, such as blasting which emits silica from the media abrasives as well as contaminants from the exterior coatings. Additional inhalation hazards range from engine and fuel emissions, chemical agents, radiation, and explosives, to naturally occurring and human-manufactured biopathogens. Of notable concern are emissions in forward-deployment areas, including urban pollution, particulates released from runway construction and maintenance activities, and combustion from burn pits containing hazardous and unknown combinations of …