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Articles 541 - 570 of 26298
Full-Text Articles in Entire DC Network
Evaluating The Role Of Stress, Self-Perceptions Of Health, And Self-Efficacy On Physical Activity Over Time: Results From Project Drive, Ashlynn Riley, Allison Sweeney, Dawn K. Wilson
Evaluating The Role Of Stress, Self-Perceptions Of Health, And Self-Efficacy On Physical Activity Over Time: Results From Project Drive, Ashlynn Riley, Allison Sweeney, Dawn K. Wilson
Caravel Undergraduate Research Journal
Most Americans are not meeting the recommended levels of physical activity. In underserved communities, these inequities are even greater, with African American women being less likely to engage in physical activity and being at greater risk for chronic disease relative to non-minority women. This study seeks to further understand the factors that support or undermine engagement in physical activity among African American women. Specifically, the present study evaluates the impact of stress, self-perceptions of health, and self-efficacy on physical activity engagement in a 10-week physical activity intervention program for African American women. Participants (N = 33) completed measures of …
Isass Brave New Continuing Medical Education World: The Stifling Of Innovation In Spine Surgery Through Overrestriction Of Collaboration, Morgan P. Lorio, Kai-Uwe Lewandrowski, Óscar L. Alves, Avelino Parajón, Matthew Scott-Young, Hansen A. Yuan, Alex R. Vaccaro
Isass Brave New Continuing Medical Education World: The Stifling Of Innovation In Spine Surgery Through Overrestriction Of Collaboration, Morgan P. Lorio, Kai-Uwe Lewandrowski, Óscar L. Alves, Avelino Parajón, Matthew Scott-Young, Hansen A. Yuan, Alex R. Vaccaro
Department of Orthopaedic Surgery Faculty Papers
BACKGROUND: in 2020, the accreditation Council for Continuing Medical education (aCCMe) released the Standards for Integrity and Independence in Accredited Continuing Medical Education, effective january 1, 2022, to ensure that accredited activities are accurate, balanced, evidence-based, and clearly separated from marketing and sales. although these aims are broadly supported, implementation may have unintended consequences in procedure-intensive specialties such as spine surgery, where surgeon–industry collaboration often drives device innovation, clinical trials, and dissemination of new techniques.
OBJECTIVE: To examine how current interpretations of ACCME eligibility and financial-relationship standards may affect continuing medical education in spine surgery and to propose practical adaptations …
A Cross-Cultural Investigation Of Consumer Hoarding Behavior During Covid-19: Differences Between Sweden And The United States, Christy M. Cook, Pia A. Albinsson, James E. Stoddard
A Cross-Cultural Investigation Of Consumer Hoarding Behavior During Covid-19: Differences Between Sweden And The United States, Christy M. Cook, Pia A. Albinsson, James E. Stoddard
Atlantic Marketing Journal
This study is a cross-cultural exploration of consumer hoarding behavior during Covid-19; specifically, a comparison between Sweden and the United States. This research analyzes whether Swedish and American consumer hoarding behavior factors of prosocial orientation, consumer resilience and consumer risk-taking propensity reflect identical relationships during less predictable environmental forces (i.e., Covid-19 or global pandemic). Results from Partial Least Squares-Structural Equation Modeling (PLS-SEM) show that consumer prosocial orientation is negatively related to consumer hoarding and prosocial orientation is positively related to consumer resilience. In turn, both prosocial orientation and consumer resilience exhibit a positive relationship towards consumer hoarding. Consumer resilience is …
The Effect Of Stress Hormones On Memory Formation And Academic Performance, Emma L. Hooks
The Effect Of Stress Hormones On Memory Formation And Academic Performance, Emma L. Hooks
Senior Honors Theses
With chronic stress becoming increasingly prevalent in academic settings, researchers have identified significant effects on learning and academic performance. Cortisol, a glucocorticoid hormone, is released following the activation of the hypothalamic-pituitary-adrenal (HPA) axis and plays a vital role in the stress response. Although acute increases in cortisol can improve attention and memory, sustained activation of the stress response can impair memory, executive functioning, and academic performance. This thesis draws on neuroscience, psychology, and education research to examine how chronic cortisol exposure affects the hippocampus and prefrontal cortex, and how the effects manifest in learning and academic performance, particularly in developmental …
Measuring Disability Prevalence In Healthcare: A Study Comparing Two Disability Measures, Kristen L. Milefchik, Rhonda K. Dailey, Sharon Milberger
Measuring Disability Prevalence In Healthcare: A Study Comparing Two Disability Measures, Kristen L. Milefchik, Rhonda K. Dailey, Sharon Milberger
Developmental Disabilities Network Journal
People with disabilities experience significant health disparities and interventions are needed to address them. Measuring disability prevalence is an essential aspect of designing effective, data-driven healthcare strategies. Accurately measuring disability prevalence is challenging given disability is a complex phenomenon, with biological, social, environmental, and cultural components. Previous studies have compared a variety of disability status measurements and found that measurements were incongruent with each other. This study examines the concordance between disability status using two different measures: the nationally recognized American Community Survey (ACS-6) functional difficulty questions and one disability identity question. We used data from 3,621 adult patients participating …
Delivering Food, Exercise, And Nutrition Education For The Prevention Of Chronic Disease, Ava Caron
Delivering Food, Exercise, And Nutrition Education For The Prevention Of Chronic Disease, Ava Caron
Human Nutrition and Hospitality Management Undergraduate Honors Theses
Chronic diseases such as diabetes, heart and respiratory diseases, cancer, and stroke pose significant health challenges in the United States, with Arkansas experiencing some of the highest rates of related mortality. This project aimed to improve health literacy related to nutrition and physical activity among adults at risk for chronic disease in Arkansas, focusing on those living independently in Ozark, Ouachita, and Delta regions, as well as cooperative extension agents in Family & Consumer Sciences. Using a mixed-methods approach involving surveys and focus groups, the study explored participants’ nutrition knowledge, health awareness, physical activity engagement, and preferred methods of receiving …
The Intersection Between Adolescent Pregnancy, Mental Health Concerns, Stigma, And Sex Education, Madelon Cox
The Intersection Between Adolescent Pregnancy, Mental Health Concerns, Stigma, And Sex Education, Madelon Cox
Honors Program: Senior Projects (Public)
This thesis discusses research from the past two decades focused on factors contributing to an increased risk of adolescent pregnancy and the lasting impact of that pregnancy. The consequences of being a pregnant adolescent can be compounded by race, gender, socioeconomic class, and access to education. Adolescent pregnancy also carries significant physical and mental health risk for the adolescent and the child. Awareness and various interventions can help pregnant adolescents or those who may be at risk for adolescent pregnancy to support them, prevent isolation, and reduce further negative mental health conditions, such as depression and anxiety.
Treatment And Interventions For Sexual Assault In Humanitarian Contexts: Addressing Gaps In Refugee And Idp Camp Care In Myanmar, Erin Nash
Capstone Experience: Master of Public Health
Sexual and gender-based violence (SGBV) remains a pervasive yet under-addressed issue in humanitarian settings. Refugee and internally displaced person (IDP) camps along the Thai– Myanmar border represent a complex nexus of protracted displacement, ethnic conflict, and limited access to medical and psychosocial care. Although the prevalence of sexual assault in these contexts is well-documented, there is a critical gap in the literature regarding effective, context-specific treatment and intervention strategies. This capstone project conducts a comprehensive review of existing research on sexual assault care in humanitarian crises worldwide and assesses its applicability to displaced ethnic minorities from Myanmar. The analysis considers …
Plan To Develop A Theory-Based Diabetes Social Media Campaign For Spanish-Speaking Adults In Finney County, Ks: Integration Of A Promotora, Focused Discussion Groups, And Community Feedback To Ensure Cultural Appropriateness, Julevi P. Bernido
Capstone Experience: Master of Public Health
The 2025 Community Health Needs Assessment (CHNA) shows that over 11% of adults in Finney County, Kansas, have diabetes, which surpasses both state and national averages. Census data from 2016-2020 indicate that 42.6% of residents ages five and older speak a language other than English at home, and 36.1% speak Spanish (United States Census Bureau, n.d.). The CHNA further highlights concerns about language and cultural barriers to care, especially among the Spanish-speaking population. Notably, 21.74% of residents have limited English proficiency—much higher than the state’s 12.1% (CHNA, 2025).
This capstone will develop a theory-based social media campaign plan to support …
Gestational Diabetes And Social Determinants Of Health In Black Women, Darianne Greenwood
Gestational Diabetes And Social Determinants Of Health In Black Women, Darianne Greenwood
Capstone Experience: Master of Public Health
Gestational Diabetes Mellitus (GDM) poses significant health risks, specifically increasing the risk of developing Type 2 Diabetes post-delivery, as well as increasing the risk of adverse neonatal and maternal outcomes. Black women, in particular, experience disproportionately higher rates of GDM incidence, severity, and complications in comparison to White women. Biological factors alone do not account for these disparities, necessitating a deeper examination into how systemic factors, particularly the social environment, influence these inequitable health outcomes. The purpose of this comprehensive literature review is to answer the question: “How do the Social Determinants of Health (SDoH), such as residential segregation, food …
Addressing Socioeconomic Factors Related To Health Disparities In Predominantly Hispanic Texas Communities, Gabriela M. Gomez
Addressing Socioeconomic Factors Related To Health Disparities In Predominantly Hispanic Texas Communities, Gabriela M. Gomez
Theses & Dissertations
This qualitative study examined the socioeconomic factors that influenced health outcomes in predominantly Hispanic Texas communities in San Antonio, Texas. Few studies have been conducted that address how socioeconomic conditions have shaped the lives of the Hispanic population in Texas, indicating a significant gap in the research. The research question guiding this study asked: How do Hispanic individuals between the ages of 26 and 64 who live in predominantly Hispanic communities describe health disparities in San Antonio, Texas? To address the research question, a qualitative inquiry was conducted using semi-structured in-person interviews with participants who met the inclusion criteria. A …
Group B Streptococcus In Pregnant Women: Universal Guidelines And Protocols, Dania Presteguin
Group B Streptococcus In Pregnant Women: Universal Guidelines And Protocols, Dania Presteguin
Undergraduate Honors Thesis Collection
Background: Group B Streptococcus (GBS) is a leading cause of maternal sepsis and neonatal mortality globally. Variability in screening and treatment guidelines influences global disease burden.
Objective: This study uses a cross-national analysis to compare screening and treatment guidelines and their impact on prevalence, screening, intrapartum antibiotic prophylaxis (IAP), and maternal-neonatal clinical manifestations Methodology: A systematic review of secondary literature was conducted using PubMed, Scopus, and CINAHL (2010-2025). Inclusion criteria include maternal GBS colonization and one or more measures of interventions and neonatal infection rates. No geographic or demographic restrictions were applied. A total of 67 studies were screened, and …
Prevention Of Dementia Using Mobile Phone Applications (Prodemos) – A Health-Economic Cost-Utility Analysis In People Aged 55–75 Years With Low Socio-Economic Status, Ron Handels, Marieke Hoevenaar-Blom, Manshu Song, Carol Brayne, Eric Moll Van Charante, Fiona E. Matthews, Junfang Xu, Linus Jönsson, Nicola Coley, Rachael Brooks, Xuening Jian, Tingting Qin, Youxin Wang, Wei Wang, Edo Richard, Anders Wimo
Prevention Of Dementia Using Mobile Phone Applications (Prodemos) – A Health-Economic Cost-Utility Analysis In People Aged 55–75 Years With Low Socio-Economic Status, Ron Handels, Marieke Hoevenaar-Blom, Manshu Song, Carol Brayne, Eric Moll Van Charante, Fiona E. Matthews, Junfang Xu, Linus Jönsson, Nicola Coley, Rachael Brooks, Xuening Jian, Tingting Qin, Youxin Wang, Wei Wang, Edo Richard, Anders Wimo
Research outputs 2022 to 2026
Introduction We aimed to explore the potential incremental cost-effectiveness of the PRODEMOS coach-supported mobile health intervention for primary prevention of dementia versus standard of care provided to people aged 55–75 years with low socio-economic status (SES) in the United Kingdom (UK), and any SES in China. Methods 12–18-month PRODEMOS trial (ISRCTN15986016) efficacy outcomes on hypertension, obesity, hypercholesterolemia, physical inactivity and smoking were extrapolated to lifetime impact on dementia onset, myocardial infarction, stroke and death using a health-economic open-source simulation model. Results Simulated outcomes showed dementia cases were avoided (UK = -206 (-658 to 281), China = -140 (-456 to 205) …
The Flourishing Child: Study Protocol For An Acceptability And Feasibility Trial Of A Digital Early Childhood Flourishing Intervention, Zenobia Talati, Jack Kennare, Natasha L. Bear, Lisa Y. Gibson, Robyn Power, Van Zyl Kruger, Desiree Silva, Susan L. Prescott, Jacqueline A. Davis
The Flourishing Child: Study Protocol For An Acceptability And Feasibility Trial Of A Digital Early Childhood Flourishing Intervention, Zenobia Talati, Jack Kennare, Natasha L. Bear, Lisa Y. Gibson, Robyn Power, Van Zyl Kruger, Desiree Silva, Susan L. Prescott, Jacqueline A. Davis
Research outputs 2022 to 2026
Background: Globally, rates of children with physical and mental health problems are increasing. Health issues in early childhood often persist into adulthood, highlighting the need to ensure children are supported to flourish from the start of life. Objectives: This protocol describes methods used to test the acceptability and feasibility of a novel digital Flourishing Intervention (designed to empower parents and promote child wellbeing), comprising a Flourishing Check (a newly developed online questionnaire) and a Pathway Tool (an online directory of high-quality, evidence-based programmes and resources). Methods: Using a randomised feasibility trial, participants (N = 600 parents of children aged 0–5 …
Seeing Skin, Seeking Evidence: Lessons From A Dermatology Internship, Isabella Floyd
Seeing Skin, Seeking Evidence: Lessons From A Dermatology Internship, Isabella Floyd
Health, Human Performance and Recreation Undergraduate Honors Theses
Background: Indoor tanning exposes individuals to artificial ultraviolet (UV) radiation through devices such as tanning beds and sunlamps, increasing the risk of skin damage and malignancy. Prior research suggests associations between indoor tanning and melanoma, basal cell carcinoma (BCC), and squamous cell carcinoma (SCC), with potential variation based on age of initiation and cumulative exposure.
Purpose: The purpose of this literature review was to examine the association between indoor tanning and skin cancer risk, with a focus on age at first exposure, frequency, and duration of tanning bed use across melanoma, BCC, and SCC outcomes.
Methodology: A structured literature review …
An Evaluation Of Leading Indicators In The Construction Industry And Their Relationship With Incident Rates, Kitti Miller Whalen
An Evaluation Of Leading Indicators In The Construction Industry And Their Relationship With Incident Rates, Kitti Miller Whalen
All-Inclusive List of Electronic Theses and Dissertations
Improving safety programs has been a focus of organizations for decades. Historically, focus has been directed towards lagging indicators such as recordable incident rates and experience modification rate (EMR). While these remain beneficial, they are only one component of the broader framework. In recent years, companies have started to examine what occurs prior to an incident, which are known as leading indicators. The research into leading indicators is promising, however research into the area is limited. The focus of this study is to identify which leading indicators are most strongly associated with improved incident rates in the construction industry specifically. …
Observation And Reflection Of Neighborhood And Community 2026: Sdohs: Environment, Food Scarcity, Community, Leigha Diegel, Ryan Smith, Haidy Aziz, Timothy Zhu, Lauren Timmer, Christian Smolen, Tavan Zadeh, Danielle Foster
Observation And Reflection Of Neighborhood And Community 2026: Sdohs: Environment, Food Scarcity, Community, Leigha Diegel, Ryan Smith, Haidy Aziz, Timothy Zhu, Lauren Timmer, Christian Smolen, Tavan Zadeh, Danielle Foster
Patient Education Projects
No abstract provided.
Evaluating The Impact Of Myplate-Based Expanded Food And Nutrition Education Program (Efnep) On Healthy Dietary Choices Among Low-Income Families, Theresa N. Agbonome
Evaluating The Impact Of Myplate-Based Expanded Food And Nutrition Education Program (Efnep) On Healthy Dietary Choices Among Low-Income Families, Theresa N. Agbonome
Electronic Theses, Projects, and Dissertations
Dietary behaviors towards healthy food choices remain a major public health issue in the United States, with prevalence among low-income families. The University of California Agriculture and Natural Resources (UCANR) with Expanded Food and Nutrition Education Program (EFNEP) trains both health educators and volunteers to provide community-based nutrition education, which prioritizes low-income families. The initiative employs the MyPlate guidelines that are composed of 5 different food groups which include fruits, vegetables, protein, grains, and dairy products. This project focuses on evaluating nutritional habits of disadvantaged families within San Bernardino County (SBC) by using an evidence-based evaluation tool known as the …
Assessing The Needs Of Public Health Professionals In The Inland Empire, Esteban Silva-Garcia
Assessing The Needs Of Public Health Professionals In The Inland Empire, Esteban Silva-Garcia
Electronic Theses, Projects, and Dissertations
An effective public health system relies on the need for highly trained professionals with degrees or certifications within the field of public health. As public health continues to evolve, professionals are required to improve and evolve with the pace of technology and knowledge advancements. This project focuses on reviewing literature on the current ongoing needs of public health professionals and providing them with resources that are available at low to no cost. It surveys the needs of public health professionals in the Inland Empire and the solutions created by organizations and federal agencies to support professional development for current and …
The Quantification Of Fluoride Water Quality And Its Significance On Oral Health, Harleen Kaur Maroak
The Quantification Of Fluoride Water Quality And Its Significance On Oral Health, Harleen Kaur Maroak
Electronic Theses, Projects, and Dissertations
Fluoride is a naturally occurring mineral and studies have shown that when added to community water supplies, it effectively reduces dental caries. According to the U.S. Public Health Services (PHS), 0.7mg/L is the optimal fluoride level in drinking water to prevent tooth decay. This study focuses on examining the fluoride levels in water in San Bernardino County (SBC) and Riverside County (RC). Data is collected from recently published articles, databases along with assessing the laboratory water sample (n=45) analysis to determine if the fluoride levels are meeting the optimal standards. In SBC, there are total of 154 water systems with …
Tips For Health Care Practitioners: A Guide For Adolescent Obesity, Regina Santana
Tips For Health Care Practitioners: A Guide For Adolescent Obesity, Regina Santana
Electronic Theses, Projects, and Dissertations
Adolescent obesity continues to be a significant public health concern that is associated with long term physical consequences. The purpose of this project was to develop an evidence based, user friendly guidebook that supports healthcare professionals in the education of adolescents with obesity and their families. A structured literature review development process was used to inform the current development of the guidebook. The guidebook includes components of obesity management such as nutrition and physical activity recommendations. The validity of the content was established through the evaluation of five healthcare professionals that include registered dietitians and licensed therapists. The guidebook was …
The Physiological And Psychological Effects Of Social Media Addiction: A Mixed Methods Study, Ella M. Roper
The Physiological And Psychological Effects Of Social Media Addiction: A Mixed Methods Study, Ella M. Roper
Biological Sciences Undergraduate Honors Theses
Abstract
Objectives: This study sought to examine the physiological and psychological effect of social media addiction displayed through sleep quality, cortisol levels, heart rate, and emotional affect in students at the University of Arkansas.
Methods: Seven adults (Age range = 18-21; 100% female) participated in a mixed-methods study investigating social media addiction across a two-week period. Sleep quality and duration were assessed using the Pittsburgh Sleep Quality Index (PSQI). Participants provided saliva samples which were used to quantify cortisol levels. For two weeks, participants were asked to spend at least ten minutes on social media daily and to report their …
Exploring Sexually Explicit Material Literacy In Compressive Sex Education, Ashton Payne
Exploring Sexually Explicit Material Literacy In Compressive Sex Education, Ashton Payne
Health, Human Performance and Recreation Undergraduate Honors Theses
Background: Adolescents increasingly encounter sexually explicit material (SEM) through digital media, often before receiving formal instruction about sexuality, relationships, or consent. This early and unmediated exposure has prompted growing interest in pornography literacy as a necessary component of comprehensive sex education (CSE). Purpose: This literature review synthesizes empirical research published between 2015 and 2025 examining pornography literacy pedagogy, its implementation within CSE, and its documented impacts on adolescent knowledge, attitudes, and behaviors. Methods: The University of Arkansas’s OneSearch served as the primary search engine, drawing from major academic databases including ProQuest, PubMed, Web of Science, JSTOR, and …
The Lasting Impact: Aces, Foster Care Placement, And Lifespan Development, Abigail J. Luth
The Lasting Impact: Aces, Foster Care Placement, And Lifespan Development, Abigail J. Luth
Theses/Capstones/Creative Projects
Research shows that children in foster care experience adverse childhood experiences at a disproportionately high rate. This significantly impacts developmental, and health outcomes across ones lifetime. Through interviews with field specialists and individuals with experience in foster care, a qualitative analysis was conducted to identify thematic responses and draw conclusions. Interviewees were briefed on the project and gave consent to participate. Key findings included a high ACE score prevalence among foster youth as well as a need for stability in home placements. Further research should be done to look into how professionals can help make the transition into foster care …
Barriers And Facilitators Of Childhood Immunization: A Mixed Methods Assessment Of Health Care And Community Health Professionals’ Observations, Jenny Dong
Theses/Capstones/Creative Projects
Childhood immunization has led to significant decreases in the burden of infectious disease morbidity and mortality. Despite these contributions, U.S. childhood vaccination rates have been declining in recent years, and updates to the federal immunization schedule have removed recommendations for several childhood vaccinations. Amid such an uncertain public health landscape, understanding how environmental conditions affect childhood immunization behaviors is crucial for ensuring that children receive the vital protections vaccines offer. Thus, the purpose of this study is to examine the barriers and facilitators of childhood immunization observed by Nebraska health care professionals (HCPs). This study utilized an online questionnaire and …
The Undergraduate Education And Scientific Literacy: Exploring How College Influences Student Perception Of Covid-19 Events, Peyton Brooking
The Undergraduate Education And Scientific Literacy: Exploring How College Influences Student Perception Of Covid-19 Events, Peyton Brooking
Theses/Capstones/Creative Projects
Current undergraduate students received much of their education following the events of the COVID-19 pandemic. Many of these students experienced pandemic events before receiving any or most of their science-based higher education. Exploring their progress through higher education, and how it retroactively influenced their perception of pandemic events, serves as an informative research area. This study explores how undergraduate education in the sciences influences student engagement with complex recent events in science. In addition, this study asked how higher education builds confidence in interpreting this information. Additionally, students were surveyed to understand their scientific literacy baseline at the beginning of …
Beyond The Cycle: How Menstruation Influences Gender Identity And Well-Being In Binary And Non-Binary Adults, Rin Nguyen
Beyond The Cycle: How Menstruation Influences Gender Identity And Well-Being In Binary And Non-Binary Adults, Rin Nguyen
College of Education and Human Sciences: Dissertations, Theses, and Student Research
Approximately 1.8 billion people worldwide menstruate, including transgender and gender-diverse (TGD) people, yet their experiences remain underrepresented in research. Given that menstruation can affect gender alignment and psychological well-being, understanding its impact on TGD people is critical. Gender congruence, or alignment between one’s gender identity and expression, is a key factor influencing well-being, with research linking it to reduced depression and anxiety. Furthermore, emerging research on gender euphoria, the joy experienced when gender congruence is experienced, suggests it may serve as a protective factor for mental health and well-being. Gender euphoria has been associated with reduced psychological distress and increased …
Factors Affecting Pedestrian-Vehicle Conflicts: An Empirical Analysis, Christo D. Jamo
Factors Affecting Pedestrian-Vehicle Conflicts: An Empirical Analysis, Christo D. Jamo
Honors Scholar Theses
The number of pedestrian deaths increased by 78% between 2009 and 2023, while other motor vehicle crash deaths increased by 13% in the same period [1]. To identify potential pedestrian safety measures, this study analyzed the effects of location-based demographics, pedestrian phasing type, and other physical infrastructure and behavior variables on the probability of pedestrian-vehicle conflicts at signalized intersections, which is a surrogate measure of crash risk. Data were collected from 55 intersections in Connecticut, and the pedestrian-vehicle interactions were classified by severity based on the Swedish Traffic Conflict Technique: undisturbed passage, potential conflict, minor conflict, or serious conflict. Because …
Editorial: Grateful And Thankful, Michelle C. Dziurgot
Editorial: Grateful And Thankful, Michelle C. Dziurgot
The Journal of the Michigan Dental Association
Dr. Michelle Dziurgot reflects on her concluding three-year term as the Editor-in-Chief of the Michigan Dental Association Journal. She describes her personal growth through volunteerism, starting as a local component editor and advancing to the MDA Board of Trustees. The author emphasizes that the most value from membership comes through immersion and service, encouraging others to volunteer their time and talent to the association. She credits the MDA’s mentorship with shaping her professional career and practice.
Ligand-Based Pharmacophore Modeling And Structure-Based Virtual Screening For Identifying Potential Therapeutic Agents Targeting The Sars-Cov-2 Spike Protein-Ace2 Receptor Interaction, Timoteo Delgado-Maldonado, Gilberto Vargas-Salas, Debasish Bandyopadhyay, Adriana Moreno-Rodriguez, Eyra Ortiz-Pérez, Gildardo Rivera-Sanchez
Ligand-Based Pharmacophore Modeling And Structure-Based Virtual Screening For Identifying Potential Therapeutic Agents Targeting The Sars-Cov-2 Spike Protein-Ace2 Receptor Interaction, Timoteo Delgado-Maldonado, Gilberto Vargas-Salas, Debasish Bandyopadhyay, Adriana Moreno-Rodriguez, Eyra Ortiz-Pérez, Gildardo Rivera-Sanchez
School of Integrative Biological & Chemical Sciences Faculty Publications
Coronavirus disease (COVID-19) remains a global health concern due to its high mortality and morbidity. In this study, we combined ligand-based pharmacophore modeling (LBPM) with structure-based virtual screening (SBVS) to identify novel inhibitors targeting the SARS-CoV-2 spike protein. Ligands from the MolPort database were screened via docking and molecular dynamics simulations at the receptor-binding domain (RBD). Four compounds showed promising docking scores (-8.7 to -6.4 kcal/mol) and dynamic stability (root mean square deviation < 5 Å). In vitro assays confirmed that compounds C3 (IC50 = 0.03 µM) and C4 (IC50 = 10.4 µM) effectively inhibited spike-ACE2 binding with low cytotoxicity (CC50 > 100 µM). These findings show the efficacy of the LBPM technique and highlight 1H-pyrazol-5-ol derivatives as potential building blocks for developing new antiviral agents against SARS-CoV-2.