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Assessment Of Social, Dietary And Biochemical Correlates Of Cardiometabolic Risk In Pre-Adolescent Hispanic Children, Abraham Basil Alhassan May 2017

Assessment Of Social, Dietary And Biochemical Correlates Of Cardiometabolic Risk In Pre-Adolescent Hispanic Children, Abraham Basil Alhassan

Electronic Theses and Dissertations

Obesity, elevated blood pressure and dyslipidemia are highly prevalent in Hispanic children. Compared to their non-Hispanic White peers, Hispanic children experience higher prevalence of obesity and hypertension. The Hispanic population in Tennessee has been growing, with about a tenth of newborn babies being Hispanic. This study aimed to: 1. Examine the influence of sociodemographic factors on Hispanic children’s cardiometabolic risk; 2. Assess the relationship between food group intake and cardiometabolic risk in Hispanic children; and 3. Evaluate the efficacy of non-traditional biomarkers for detecting cardiometabolic risk in Hispanic children. Data for the study came from a larger cross-sectional pilot study …


The Increasing Risk Of Vector-Borne Diseases: Mapping The Effects Of Climate Change And Human Population Density On Future Aedes Aegypti Habitats, Julie Obenauer May 2017

The Increasing Risk Of Vector-Borne Diseases: Mapping The Effects Of Climate Change And Human Population Density On Future Aedes Aegypti Habitats, Julie Obenauer

Electronic Theses and Dissertations

The Aedes aegypti mosquito is the vector for four infectious diseases of global concern – Yellow Fever, Dengue, Chikungunya, and Zikavirus. Previous attempts to model the expansion of the vector habitat due to global climate change have rarely included characteristics related to the human populations on which this mosquito is dependent. The purpose of this research was to determine whether the inclusion of human population density improves model performance while creating risk maps that can be used to determine where humans are most likely to be exposed to the vector in the future. The resulting model demonstrated that the inclusion …


Meaning Of Pregnancy Terms Among African-American Women, Stephanie Solomon, Sandra G. Suther, Ivette Lopez, Alicestine Ashford, Linda C. Amankwaa, Gareth Dutton May 2017

Meaning Of Pregnancy Terms Among African-American Women, Stephanie Solomon, Sandra G. Suther, Ivette Lopez, Alicestine Ashford, Linda C. Amankwaa, Gareth Dutton

The Qualitative Report

The concept of pregnancy intendedness is complex and may not bear the same meaning to all women. Moreover, researcher definition and women’s meaning were thought to be different. Some researchers have indicated that it is unclear how well women understand and relate to questions used by the National Survey of Family Growth (NSFG) and how the classifications relate to women’s lives. The purpose of this study was to explore the meaning of terms such as planned and/or intended pregnancy among African-American women of childbearing age using a qualitative exploratory descriptive method. Although African-American women want children, they are three times …


Reducing Tobacco-Related Health Disparities : Exploring The Barriers And Facilitators To Smoking Cessation Among Individuals Experiencing Homelessness., Bernadette Guzman Antoon May 2017

Reducing Tobacco-Related Health Disparities : Exploring The Barriers And Facilitators To Smoking Cessation Among Individuals Experiencing Homelessness., Bernadette Guzman Antoon

Electronic Theses and Dissertations

Although the prevalence of smoking has declined in the U.S., vulnerable populations continue to suffer from tobacco-related health disparities. An estimated 68.0-80.0% of homeless adults are current cigarette smokers compared to 15.1% in the general population. The large gap in smoking rates suggests that current tobacco cessation programs designed to reduce smoking have little impact among individuals experiencing homelessness. The purpose of this study was to explore the barriers and facilitators to smoking cessation among the homeless. The second aim of this study was to explore if the barriers and facilitators to tobacco cessation differed among male smokers experiencing homelessness …


Determining The Effects Of Social Media Monitoring To Identify Potential Foodborne Illness In Southern Nevada, Lauren Diprete May 2017

Determining The Effects Of Social Media Monitoring To Identify Potential Foodborne Illness In Southern Nevada, Lauren Diprete

UNLV Theses, Dissertations, Professional Papers, and Capstones

Foodborne illness, commonly referred to as food poisoning, affects an estimated 1 in 6 Americans every year, despite the fact that it is entirely preventable. Many cases of foodborne illness go unreported; however, better reporting leads to faster health department response and containment. Social media monitoring, using software to identify trends in social media posts, is a novel new tool that has been tested in a variety of public health fields with promising preliminary results. The Southern Nevada Health District (SNHD) has employed social media monitoring software to identify potential foodborne illness within Southern Nevada. The purpose of this study …


Evaluation Of A Fluorescence Method For Quantifying Bioaerosol Concentrations On Air Quality Filter Samples, Rachel Kolberg May 2017

Evaluation Of A Fluorescence Method For Quantifying Bioaerosol Concentrations On Air Quality Filter Samples, Rachel Kolberg

UNLV Theses, Dissertations, Professional Papers, and Capstones

Airborne particulate matter (PM) in outdoor environments contains many components that cause adverse human health effects. The size of the particulates determine in what manner the particles would bypass the body’s defense mechanisms to enter the respiratory system and is directly related to their health impacts. Currently the United States Environmental Protection Agency is enforcing the National Ambient Air Quality Standards (NAAQS) to regulate the annual and 24-hour average concentrations of PM2.5 and PM10 in the air. PM2.5 are fine particles with aerodynamic diameter <2.5μm, small enough to reach the deepest parts of the bronchi and lungs. PM10 include PM2.5 and larger particles with aerodynamic diameter of 2.5-10μm. Both PM2.5 and PM10 contain multiple components from multiple sources. Bioaerosols are an important component of PM, but there is limited knowledge about how bioaerosols contribute to PM2.5 and PM10 concentrations. There is also a lack of research about the incidence and prevalence of disease caused by bioaerosols and about the limits of exposure to bioaerosol particulates. The main barrier to assess bioaerosol concentrations and health-related effects is the absence of quick and inexpensive methodology for quantifying bioaerosols. This study explored the feasibility of using fluorescence microscopy to quickly quantify bioaerosols in PM2.5 and PM10 collected on polycarbonate filters. Bioaerosols were stained with a DNA marker directly on a filter, followed by fixation, microscopic imaging, and automatic counting. The method was first validated using reference samples prepared by depositing different known concentrations of E. coli onto blank polycarbonate filters. The results indicated a linear response over two orders of magnitude (R2 = 0.9) and an accuracy within ±25%. E. coli were also deposited onto selected ambient PM10 and PM2.5 filter samples to determine if pre-loaded particles would interfere with bioaerosol imaging and counting. It was found that despite an increase in uncertainty (variability), the calibration slope remained within ±10% of unity for both PM2.5 and PM10 samples. Bioaerosol concentrations in ambient samples, as quantified by this method, were on average 14% higher for PM10 than for PM2.5 acquired concurrently in a desert environment of Las Vegas, Nevada. The application of this method to other types of compliance filters, such as Teflon filters and tapes of a Beta Attenuation Monitor (BAM) were also explored in this study. By means of a high-yield approach this method is expected to facilitate bioaerosol research, support exposure and health assessments, and help refine NAAQS for PM2.5 and PM10.


A Rural And Urban Study Of The Food Environment In Select Nevada Geographies, Joseph Nickelson May 2017

A Rural And Urban Study Of The Food Environment In Select Nevada Geographies, Joseph Nickelson

UNLV Theses, Dissertations, Professional Papers, and Capstones

National and county level examination of urban and rural food environments has taken place, but primary validation of venue existence and in-venue data are lacking. The literature show disparities in access to healthy foods through low density of large grocers/supermarkets, low variety and quality of produce and higher prices for a healthy diet in rural versus urban geographies. Rural areas are of unique concern due to poor health indicators such as higher obesity rates, higher diabetes rates, lower incomes and lower educations than urban residents. The goal of this study was to explore differences in the community and consumer level …


An Investigation Of The Relationship Between Child, Family, And Community Factors And Early Childhood Oral Health And The Utilization Of Dental Health Services, Nicole Holt May 2017

An Investigation Of The Relationship Between Child, Family, And Community Factors And Early Childhood Oral Health And The Utilization Of Dental Health Services, Nicole Holt

Electronic Theses and Dissertations

Background / Objective: Children under the age of 5 years bear a disproportionate burden of oral disease. The aim of this study is to investigate how child, family, and community determinants impact dental care utilization, and parental report of child’s oral health. Methods: Data for this study came from the 2011/2012 National Survey of Children’s Health for children aged 1 to 5 years old. Dependent variables evaluated were if the child had an oral health problem, been to a dentist in the past year, and parents description of the child’s teeth. Independent variables were selected from child, family, and community …


Can Global Health Governance Contend With Transnational Corporate Activities? A Case Study On The Chinese Tobacco Industry, Xing Gao Apr 2017

Can Global Health Governance Contend With Transnational Corporate Activities? A Case Study On The Chinese Tobacco Industry, Xing Gao

Geography Honors Projects

In the past two decades, China’s state-owned tobacco enterprise (CNTC) has expanded its operation and influence abroad under the “going global” strategy. These globalization activities directly and indirectly impact the Framework Convention on Tobacco Control (FCTC), the first international treaty signed under the WHO auspices. In this project, I explore how certain CNTC expansionary strategies undermine FCTC articles, as well as the ways in which FCTC articles have failed to curb the tobacco industry’s transnational growth. Using international political economy as an overarching framework for the analysis of global health governance, I argue that the FCTC fails to halt the …


East Meets West: Cultural Values And Duty To Care For Disaster Response, Tracy J. Nash Apr 2017

East Meets West: Cultural Values And Duty To Care For Disaster Response, Tracy J. Nash

Nursing Theses and Dissertations

Nurses’ readiness for disaster response has assumed front and center-stage in recent years, due to the heightened number of natural and human-induced disasters across the globe. Scientific literature affirms that without nurses’ personal and professional readiness for disaster situations, patient and public health outcomes will likely decline. Three research manuscripts presented in this dissertation portfolio targeted this significant, but overlooked public health issue. First, a quantitative pilot study addressing nurses’ personal preparedness for disaster response was considered. Findings from the study not only justified personal readiness as a significant concept, but also prompted review of the scientific literature to further …


Mexicans In The U.S And Hiv: Reviewing Social And Cultural Factors, Eduardo Alvarez Apr 2017

Mexicans In The U.S And Hiv: Reviewing Social And Cultural Factors, Eduardo Alvarez

Annual Undergraduate Conference on Health and Society

Mexican immigrants in the United States continue to struggle with disproportionate incidences of HIV infection. Behaviors that contributed to the development of AIDS among Mexican immigrants were the lack of condom use, engaging in risky sexual behavior, and not having HIV testing (Martínez Donate, et al., 2015). While these risk factors are preventable, religious and social stigmatization present within the Mexican community generate shame and embarrassment. This discourages Mexican immigrants from seeking health services, such as HIV testing. An estimated 20% of HIV positive Mexican immigrants are unaware of their condition, and contribute to the spread of the virus (Hall …


Point Of Care Technology For Underserved Populations, Anna Maloney Apr 2017

Point Of Care Technology For Underserved Populations, Anna Maloney

Annual Undergraduate Conference on Health and Society

Point of Care technology is an emerging healthcare field. This technology allows for rapid, inexpensive, on-site testing for otherwise lengthy and costly laboratory tests. Leading infectious diseases can be tested immediately in non-invasive ways similar to using a pregnancy test. This inexpensive, highly portable, and extremely accurate technology should be used for populations that have historically lacked access. Such access would result in immediate cost savings and life savings.

Underserved populations in America such as migrant workers or people living in poverty rarely receive the testing they require. Although clinics for illegal immigrants exist where they are protected and cannot …


Influencing College Influenza Vaccination Through A Multi-Component Campaign, Heather Strickler Apr 2017

Influencing College Influenza Vaccination Through A Multi-Component Campaign, Heather Strickler

Evidence-Based Practice Project Reports

Multiple influenza strains exist and college aged students are the most affected population from the H1N1 strain. The H1N1 influenza pandemic had high attack rates reported on campuses from 25% to 73% (Benjamin et. al., 2016; Uddin et. al., 2009). Only 8% to 40% of college students are vaccinated against influenza despite a target goal of 50% set by the American Healthy Campus 2020 (Benjamin et. al., 2016; Poehling, et. al., 2012). The purpose of this evidence based project was after implementing a multi-component influenza vaccination campaign to determine changes in intent to receive the vaccine among college students. To …


Priority Hypertension Management Strategies For At-Risk African Americans As Perceived By Medical Clinicians And Academic Scholars, Shirley M. Timmons, Lu Shi, Amin Khademi Apr 2017

Priority Hypertension Management Strategies For At-Risk African Americans As Perceived By Medical Clinicians And Academic Scholars, Shirley M. Timmons, Lu Shi, Amin Khademi

Journal of Health Disparities Research and Practice

African American adults, in the United States (US), bear the greatest burden of high blood pressure (HBP)--a primary risk factor for cardiovascular disease and premature death. Current research does not adequately inform the design of multi-level interventions that work to control HBP in this at-risk population. The purpose of this study was to uncover information about priority strategies recommended for HBP control in African American adults. Research questions are 1) what are factors that reduce or manage HBP in at-risk African Americans and 2) what factors are important to the design and implementation of successful HBP interventions in at-risk African …


Predictors Of Hpv Vaccination Series Completion In Philadelphia Adolescents, Karie Youngdahl, Mph, Ami S. Patel, Phd, Mph, Amy E. Leader, Drph, Mph Apr 2017

Predictors Of Hpv Vaccination Series Completion In Philadelphia Adolescents, Karie Youngdahl, Mph, Ami S. Patel, Phd, Mph, Amy E. Leader, Drph, Mph

JCPH Alumni

Research Aim:

This study analyzed data from the Philadelphia KidsPlus Immunization information System (IIS) to look at factors associated with HPV vaccine series completion.

Note:

Student capstone presentation also available at: http://jdc.jefferson.edu/mphcapstone_presentation/190/


Conflict In South Asia And Its Impact On Health, Siddarth David, Rukhsana Gazi, Mohammed Shafiq Mirzazada, Chesmal Siriwardhana, Sajid Bashir Soofi, Nobhojit Roy Apr 2017

Conflict In South Asia And Its Impact On Health, Siddarth David, Rukhsana Gazi, Mohammed Shafiq Mirzazada, Chesmal Siriwardhana, Sajid Bashir Soofi, Nobhojit Roy

Department of Paediatrics and Child Health

South Asia has a large population affected by different types of protracted conflict and can provide critical insights to understand health challenges in conflict zones.
Health systems in conflict affected areas should prioritise domestic and gender-based violence, along with reproductive and sexual health services.
Mental health and psychosocial services for conflict-affected populations in South Asia need to be strengthened, and these services should be integrated into existing primary care platforms.
Building the capacity of the existing healthcare system and developing a trained local workforce can improve the access to and availability and acceptability of health services in conflict-affected communities.
Research …


Misplaced Priorities: How County Health Departments Overlook The Leading Causes Of Death, Jeremy Whitaker Apr 2017

Misplaced Priorities: How County Health Departments Overlook The Leading Causes Of Death, Jeremy Whitaker

Annual Graduate Student Symposium

Problem: Most Iowans die from chronic diseases, or diseases developed over time, often influenced through behavioral choice. The top three, heart disease, cancer, and lower respiratory diseases account for over half of all death in Iowa and in the nation. However, most public health funding focuses on infectious disease and treatment, leaving little or nothing for primary prevention of chronic diseases.

Method: The 2014 Local Governmental Public Health Survey, annual reports, and Health Improvement projects were analyzed for primary prevention of chronic diseases at county health departments. This was compared to a review of federal and state funding for chronic …


Prevention Of Drug Use And Treatment Of Drug Use Disorders In Rural Settings, John A. Gale Ms Apr 2017

Prevention Of Drug Use And Treatment Of Drug Use Disorders In Rural Settings, John A. Gale Ms

Mental Health / Substance Use Disorders

This Guide on Prevention of Drug Use and Treatment of Drug Use Disorders in Rural Settings was prepared by the United Nations Office on Drugs and Crime (UNODC) Drug Prevention and Health Branch (DHB), in the context of the global project Treatnet II: OFID-UNODC Programme to prevent HIV/AIDS through Treatnet Phase II, with the aim of providing an awareness-raising tool and guidance for policymakers, public health officials, local authorities and other stakeholders in dealing with substance use issues in rural settings in their respective countries. This Guide will serve as an awareness-raising tool and guidance for policymakers, public health officials, …


The Influence Of Culture On The Use Of Healthcare Services By Refugees In Southcentral Kentucky: A Mixed Study, Chika N. Ejike Apr 2017

The Influence Of Culture On The Use Of Healthcare Services By Refugees In Southcentral Kentucky: A Mixed Study, Chika N. Ejike

Dissertations

The world as a global village has become a ubiquitous trope in the popular discourse, and Bowling Green, Kentucky, with its substantial immigrant population, may be considered an exemplar of this idealized community. It has become an ideal location for research regarding the challenges faced by immigrants. Due to the diverse cultural identities of the refugee/immigrant population, it is particularly well suited for studies into complex culturally dependent healthcare utilization patterns.

The central research question for the study was as follows: What are the healthcare-seeking behavioral patterns (as influenced by culture) among refugees at their nearest healthcare facilities? This mixed …


Urine Electrolyte Excretion In A Hypertensive Population Of East Africans, Aiste Dobrovolskaite Apr 2017

Urine Electrolyte Excretion In A Hypertensive Population Of East Africans, Aiste Dobrovolskaite

Masters Theses & Specialist Projects

Chronic noncommunicable diseases (NCDs) are the largest contributor to mortality rates worldwide including in low- and middle- income countries (LMICs) which already suffer from high rates of infectious disease. Among the four major NCDs that cause 38 million deaths annually, cardiovascular disease (CVD) causes 17.5 million of these annual deaths. The primary risk factor of CVD is hypertension. Kenya, a developing country in Sub-Saharan Africa, has a high rate of hypertension with low (2.6%) management rates. Prior research from our lab has identified a population of Kenyans with a high prevalence of hypertension that is not statistically correlated with typical …


Rural Opioid Prevention And Treatment Strategies: The Experience In Four States [Policy Brief], John A. Gale Ms, Anush Yousefian Hansen Ms,Ma, Martha Elbaum Williamson Mpa Apr 2017

Rural Opioid Prevention And Treatment Strategies: The Experience In Four States [Policy Brief], John A. Gale Ms, Anush Yousefian Hansen Ms,Ma, Martha Elbaum Williamson Mpa

Mental Health / Substance Use Disorders

Little is known about what states with large rural populations are doing to combat opioid use disorders (OUD) in rural communities. This qualitative study identified rural challenges to the provision of OUD prevention, treatment, and recovery services and explored promising strategies to tackle the opioid crisis in rural communities.


Rural Opioid Prevention And Treatment Strategies: The Experience In Four States [Working Paper], John A. Gale Ms, Anush Hansen Ms,Ma, Martha Elbaum Williamson Mpa Apr 2017

Rural Opioid Prevention And Treatment Strategies: The Experience In Four States [Working Paper], John A. Gale Ms, Anush Hansen Ms,Ma, Martha Elbaum Williamson Mpa

Mental Health / Substance Use Disorders

Although opioid use rates are comparable in rural and urban counties, rural opioid users tend to be younger, unmarried, have lower incomes, and are more likely to lack health insurance, all vulnerabilities that may negatively impact their ability to seek treatment and recover. Additionally, the rural health care system is characterized by numerous resource, workforce, access, and geographic challenges that complicate the delivery of specialized care for OUDs in rural communities. The nature and scope of the opioid crisis vary across rural communities and require multifaceted, community-based strategies to address the problem. Based on interviews with key stakeholders in Indiana, …


A Comparison Of Influenza & Tdap Vaccination Rates By Characteristics Of Child-Bearing-Aged Women, Francis Connor, Dnp, Msn, Mph, Fnp-Bc Apr 2017

A Comparison Of Influenza & Tdap Vaccination Rates By Characteristics Of Child-Bearing-Aged Women, Francis Connor, Dnp, Msn, Mph, Fnp-Bc

Doctor of Nursing Practice Projects

Background

The Advisory Committee on Immunization Practices recommend childbearing-aged women receive an annual influenza vaccine, one dose of Tdap instead of TD after 18 years of age, and one dose of Tdap during the 3rd trimester of each pregnancy. Despite these recommendations, influenza and Tdap vaccination rates remain lower than current goals.

Objectives

The purpose was to assess influenza and Tdap vaccination rates among women of childbearing age by pregnancy status, age group, and race/ethnicity.

Methods

The retrospective secondary data analysis included a nationally representative sample of women aged 18 to 44 years from the 2014 Behavioral Risk Factors …


Shifting Mental Health From The Back Burner: An Investigation Of The Mental Health Treatment Gap, Eva Hanorah Stanton Apr 2017

Shifting Mental Health From The Back Burner: An Investigation Of The Mental Health Treatment Gap, Eva Hanorah Stanton

Independent Study Project (ISP) Collection

The purpose of this research project is to investigate solutions to the so-called ‘mental health treatment gap’. The need for scholarship in this area is underscored by the recent tragedy in the Gauteng province, which has brought the neglect of the mental health sector into the public eye. Through semi-structured interviews with six key stakeholders in the fields of mental health and health policy this project seeks to better understand the causes of the mental health treatment gap and the impact National Health Insurance (NHI) rollout may have on access to quality mental healthcare. Sub-themes explored include: the integration of …


Access To Information And Services Regarding Maternal Health And Healthcare Within Tribal Communities Around Udaipur, Rajasthan, Arista Jhanjee Apr 2017

Access To Information And Services Regarding Maternal Health And Healthcare Within Tribal Communities Around Udaipur, Rajasthan, Arista Jhanjee

Independent Study Project (ISP) Collection

The following study seeks to investigate access to antenatal and delivery-related services and information among women residing in rural, tribal communities around Udaipur, Rajasthan, and to analyze determinants that affect such access. More specifically, it seeks to evaluate one determinant in particular: that of association with and use of the services provided by the nonprofit organization Seva Mandir, which works with rural communities throughout southern Rajasthan in order to facilitate the improvement of health and development activities and outcomes. Methods used for the collection of the data upon which the study draws were qualitative: interviews were conducted with 27 women …


Bioaerosol Exposures From Three Utah Cattle Operations, Clark Evans Apr 2017

Bioaerosol Exposures From Three Utah Cattle Operations, Clark Evans

Graduate Theses & Non-Theses

Bioaerosol is a generic term used to describe dusts that are produced by and or contain biological material. These dusts can potentially contain the following hazardous agents; bacteria, viruses, bacterial endotoxins, and/or mycotoxins from mold spores. Respiratory inflammation, allergies, cancers, and infectious diseases can occur from exposure to a variety of bioaerosol agents. Controlling bioaerosol exposures is very complicated due to the limited amount of research available and because there are no established regulatory or authoritative exposure limits.

Three cattle operations, two beef and one Dairy, in Utah were investigated to establish exposure profiles of the full-time employees that directly …


Maternal Characteristics And Obstetrical Complications Impact Neonatal Outcomes In Indonesia: A Prospective Study., Trisari Anggondowati, Ayman A E El-Mohandes, S Nurul Qomariyah, Michele Kiely, Judith J Ryon, Reginald F Gipson, Benjamin Zinner, Anhari Achadi, Linda L Wright Mar 2017

Maternal Characteristics And Obstetrical Complications Impact Neonatal Outcomes In Indonesia: A Prospective Study., Trisari Anggondowati, Ayman A E El-Mohandes, S Nurul Qomariyah, Michele Kiely, Judith J Ryon, Reginald F Gipson, Benjamin Zinner, Anhari Achadi, Linda L Wright

Medicine Faculty Publications

BACKGROUND: We investigated associations between maternal characteristics, access to care, and obstetrical complications including near miss status on admission or during hospitalization on perinatal outcomes among Indonesian singletons.

METHODS: We prospectively collected data on inborn singletons at two hospitals in East Java. Data included socio-demographics, reproductive, obstetric and neonatal variables. Reduced multivariable models were constructed. Outcomes of interest included low and very low birthweight (LBW/VLBW), asphyxia and death.

RESULTS: Referral from a care facility was associated with a reduced risk of LBW and VLBW [AOR = 0.28, 95% CI = 0.11-0.69, AOR = 0.18, 95% CI = 0.04-0.75, respectively], stillbirth …


Th1 Differentiation Drives The Accumulation Of Intravascular, Non-Protective Cd4 T Cells During Tuberculosis, Michelle A. Sallin, Shunsuke Sakai, Keith D. Kauffman, Howard A. Young, Jinfang Zhu, Daniel L. Barber Mar 2017

Th1 Differentiation Drives The Accumulation Of Intravascular, Non-Protective Cd4 T Cells During Tuberculosis, Michelle A. Sallin, Shunsuke Sakai, Keith D. Kauffman, Howard A. Young, Jinfang Zhu, Daniel L. Barber

United States Public Health Resources

Recent data indicate that the differentiation state of Th1 cells determines their protective capacity against tuberculosis. Therefore, we examined the role of Th1-polarizing factors in the generation of protective and non-protective subsets of Mtb-specific Th1 cells. We find that IL-12/23p40 promotes Th1 cell expansion and maturation beyond the CD73+CXCR3+T-betdim stage, and T-bet prevents deviation of Th1 cells into Th17 cells. Nevertheless, IL- 12/23p40 and T-bet are also essential for the production of a prominent subset of intravascular CX3CR1+KLRG1+ Th1 cells that persists poorly and can neither migrate into the lung parenchyma nor control Mtb growth. Furthermore, T-bet suppresses development of …


Development Of Tools For Stable Transfection In The Human Filarial Parasite Brugia Malayi Via The Piggybac Transposon System, Johan Chabanon Mar 2017

Development Of Tools For Stable Transfection In The Human Filarial Parasite Brugia Malayi Via The Piggybac Transposon System, Johan Chabanon

USF Tampa Graduate Theses and Dissertations

Brugia malayi is one of three species of nematode known to cause lymphatic filariasis (LF) in humans. LF infects over 120 million people, causing debilitating disease. Various global programs have been launched in the past 20 years to eliminate LF. These programs have greatly scaled up the resources and efforts allocated to halting the transmission and reducing disease burden. Only a few drugs are used to treat LF, and resistance is thus a devastating possibility. Research aimed at identifying new drug targets could therefore prove essential in elimination of LF.

Genetic manipulation of B. malayi has been limited to transient …


The Zika Virus Threat: How Concerns About Scientists May Undermine Efforts To Combat The Pandemic, Thomas G. Safford, Lawrence C. Hamilton, Emily Whitmore Mar 2017

The Zika Virus Threat: How Concerns About Scientists May Undermine Efforts To Combat The Pandemic, Thomas G. Safford, Lawrence C. Hamilton, Emily Whitmore

Carsey Publications

Using data from the University of New Hampshire’s October 2016 Granite State Poll, authors Thomas Safford, Lawrence Hamilton, and Emily Whitmore investigate how New Hampshire residents view the Zika crisis. They report that most New Hampshire residents believe Zika is only a minor threat to public health in the United States, and they generally trust the CDC as a source of information about the virus. The data also show that, while there is doubt about the government’s ability to control the spread of the virus, the public feels that emergency federal funding to combat Zika should be a priority. They …