Digital Commons Network^™

The Vaccine Industry: Does It Need A Shot In The Arm?, Eileen Salinsky, Cole Werble

National Health Policy Forum

This paper broadly examines the scientific, regulatory, and economic factors that contribute to constrained vaccine production capacity, periodic vaccine shortages, and perceptions of inadequate investment in new vaccine product development. It describes the vaccine development and production processes and summarizes how regulatory requirements influence these activities. Market dynamics related to vaccine supply and demand are also explored, including an examination of the industry’s cost structure, potential market size, and purchaser price sensitivity. A broad range of policy interventions designed to address shortcomings of the vaccine market are considered.

Gpnn: Power Studies And Applications Of A Neural Network Method For Detecting Gene-Gene Interactions In Studies Of Human Disease, Alison A. Motsinger, Stephen L. Lee, George Mellick, Marylyn D. Ritchie

Dartmouth Scholarship

The identification and characterization of genes that influence the risk of common, complex multifactorial disease primarily through interactions with other genes and environmental factors remains a statistical and computational challenge in genetic epidemiology. We have previously introduced a genetic programming optimized neural network (GPNN) as a method for optimizing the architecture of a neural network to improve the identification of gene combinations associated with disease risk. The goal of this study was to evaluate the power of GPNN for identifying high-order gene-gene interactions. We were also interested in applying GPNN to a real data analysis in Parkinson's disease.

Survey Findings: Children Served By Mainecare, 2005, Catherine Ormond, Deborah Thayer

Disability & Aging

No abstract provided.

Community Participation In Tribal Diabetes Programs, Carolyn Smith-Morris

Anthropology Research

No abstract provided.

Characteristics Of Social Smoking Among College Students, Kimberly Waters, Kari J. Harris, Sandra Hall, Niaman Nazir, Alex Waigandt

Public and Community Health Sciences Faculty Publications

Social smoking is a newly identified phenomenon in the young adult population that is poorly understood. We investigated differences in social smoking (smoking most commonly while partying or socializing) and other smoking within a convenience sample of college smokers (n = 351) from a large midwestern university. Results revealed that 70% of 351 current (past 30-day) smokers reported social smoking. No significant difference was found in motivation to quit between smoking groups. However, a significant difference was found between groups in confidence to quit, the number of days smoked, and the number of cigarettes smoked on those days. More …

Preparedness For Hiv/Aids Service Delivery: The 2005 Kenya Health Workers Survey, National Aids And Std Control Programme, Ministry Of Health Kenya

HIV and AIDS

Kenya is one of the few countries that has succeeded in changing the course of the HIV/AIDS epidemic, and there is strong evidence of a decline in incidence. However, AIDS-related deaths now exceed new infections, and almost nine out of ten Kenyan adults do not know their HIV status. The expansion of HIV services in Kenya, including voluntary counseling and training and prevention of mother-to-child transmission programs, has enabled more Kenyans to learn their status. However, this leaves out many individuals who could benefit from HIV testing and counseling, such as hospital patients. Patients who present to a health-care facility …

Yaari Dosti: Young Men Redefine Masculinity, A Training Manual, Horizons Program, Coro For Literacy, Mamta, Instituto Promundo

HIV and AIDS

This training manual, developed by the Population Council in collaboration with Instituto PROMUNDO, CORO for Literacy, MAMTA, and DAUD promotes gender equity and addresses masculinity as a strategy for the prevention of HIV. Adapted from the “Program H: Working with Young Men Series” developed in Brazil by Instituto PROMUNDO, it promotes the positive aspects of masculinity, encourages men’s participation in sexual and reproductive health, promotes respect for sexual diversity, and improves understanding of the body and sexuality. In this manual, HIV prevention is addressed within the larger framework of gender roles and relationships. Gender disparity, widely prevalent in Indian society …

Environmental Justice And The Role Of Social Capital In An Underserved Urban Community, Lorraine Ann Dillon

Community & Environmental Health Theses & Dissertations

The purpose of this qualitative study was to evaluate a community's beliefs, attitudes, and experiences regarding their neighborhood's environmental health issues and the ways in which individuals utilize social capital (the degree to which a community collaborates and cooperates) to improve their environmental health. Research correlating social capital with health status shows that the higher the level of social capital in a community, the better the health. An understanding of why some groups exhibit more social capital than others is important in improving the public health system. The study was accomplished by comparing a convenience sample of two specific groups …

Metro Richmond Latino Health Services & Resource Guide – 2006, Virginia Commonwealth University

2006 Latino Health Summit

This Guide was produced by the VCU Institute for Women’s Health, VCU Center on Health Disparities, and CLAS Act Virginia as a resource for the fall 2006 Latino Health Summit: Latino Cultures and Beliefs in Health Care. The purpose of this Guide is to provide a practical tool for community health care professionals to use in their work by assisting in cataloguing key provider and patient resources and services. The guide will be posted on the VCU Institute for Women’s Health and VCU Center on Health Disparities websites, which will be updated on a regular basis.

Day Of Dialogue On Public Sector Pricing Of Pharmaceutical Products, Population Council

Formulation/Product Development

For decades, patients, doctors, ethicists, and other interested parties have debated the economics of the pharmaceutical industry. What is the best way to get medications and related products to the people who need them, regardless of their ability to pay? Can prices be lowered without jeopardizing basic research for new drugs? Are pharmaceutical company pricing practices monopolistic? What are the legal and ethical obligations related to drugs developed—partially or fully—with public funds? The Population Council convened a daylong meeting of academics, scientists, representatives from the nonprofit sector, the pharmaceutical industry, foundations, and government donor agencies, and practicing lawyers and doctors. …

Recall Of Age Of Weaning And Other Breastfeeding Variables, Brenda Gillespie, Hannah D'Arcy, Kendra Schwartz, Janet Bobo, Betsy Foxman

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Many studies of the impact of breastfeeding on child or maternal health have relied on data reported retrospectively. The goal of this study was to assess recall accuracy among breastfeeding mothers of retrospectively collected data on age of weaning, reasons for cessation, breast pain, lactation mastitis, and pumping.

Methods

Women in Michigan and Nebraska, U.S.A. were interviewed by telephone every 3 weeks during the first 3 months after the birth of their child, and mailed a questionnaire at 6 months. A subset was interviewed again by telephone approximately 1–3.5 years after the birth. The results for the three …

Norovirus Classification And Proposed Strain Nomenclature, Du-Ping Zheng, Tamie Ando, Rebecca L. Fankhauser, R. Suzanne Beard, Roger I. Glass, Stephan S. Monroe

United States Public Health Resources

Without a virus culture system, genetic analysis becomes the principal method to classify norovirus (NoV) strains. Currently, classification of NoV strains beneath the species level has been based on sequences from different regions of the viral genome. As a result, the phylogenetic insights of some virus were not appropriately interpreted, and no consensus has been reached to establish a uniform classification scheme. To provide a consistent and reliable scientific basis for classifying NoVs, we analyzed the amino acid sequences for the major capsid protein of 164 NoV strains by first using an alignment based on the predicted 3D structures. A …

Severe Acute Respiratory Syndrome (Sars): Knowledge, Attitudes, Practices And Sources Of Information Among Physicians Answering A Sars Fever Hotline Service, J.-F. Deng, B. Olowokure, S.C. Kaydos-Daniels, H.-J. Chang, R.S. Barwick, M.-L. Lee, C.-Y. Deng, S.H. Factor, C.-E. Chiang, S.A. Maloney, The Sars International Field Team

United States Public Health Resources

In June 2003, Taiwan introduced a severe acute respiratory syndrome (SARS) telephone hotline service to provide concerned callers with rapid access to information, advice and appropriate referral where necessary. This paper reports an evaluation of the knowledge, attitude, practices and sources of information relating to SARS among physicians who staffed the SARS fever hotline service. A retrospective survey was conducted using a self-administered postal questionnaire. Participants were physicians who staffed a SARS hotline during the SARS epidemic in Taipei, Taiwan from June 1 to 10, 2003. A response rate of 83% was obtained. All respondents knew the causative agent of …

Reducing Aids-Related Stigma And Discrimination In Indian Hospitals, Vaishali Sharma Mahendra, Laelia Gilborn, Bitra George, Luke Samson, Rupa Mudoi, Sarita Jadav, Indrani Gupta, Shalini Bharat, Celine Daly

HIV and AIDS

People living with HIV/AIDS in India, as elsewhere, face stigma and discrimination in a variety of contexts. Research in India has shown that stigma and discrimination against HIV-positive people and those perceived to be infected are common in hospitals and act as barriers to seeking and receiving critical treatment and care services. Recognizing the need to move beyond documentation of the problem, three New Delhi hospitals; SHARAN, an Indian NGO; and the Horizons program, with support from the National AIDS Control Organisation (NACO), carried out an operations research project to develop and test responses to hospital-based stigma and discrimination against …

Abc Messages For Hiv Prevention In Kenya: Clarity And Confusion, Barriers And Facilitators, Julie Pulerwitz, Tiffany Lillie, Louis Apicella, Ann P. Mccauley, Tobey C. Nelson, Simon Ochieng, Peter Mwarogo, Karusa Kiragu, Edward Kunyanga

HIV and AIDS

The Horizons Program and FHI/IMPACT developed a collaborative research study to explore how adults and youth in Kenya define and perceive the ABC (abstinence/being faithful/consistent condom use) terms and behaviors. Additional objectives of the study were to identify attitudes and norms around the ABC behaviors that influence perceptions of them, and the role of important actors in transmitting messages about them. Findings highlight potential challenges in promoting each of the ABC behaviors, as well as some positive elements that can be built upon when developing programs. HIV prevention programs that incorporate ABC messages—both in Kenya and elsewhere—should consider a number …

Orphans And Vulnerable Youth In Bulawayo, Zimbabwe: An Exploratory Study Of Psychosocial Well-Being And Psychosocial Support, Laelia Gilborn, Louis Apicella, Jonathan Brakarsh, Linda Dube, Kyle Jemison, Mark Kluckow, Tricia Smith, Leslie M. Snider

HIV and AIDS

This Population Council Horizons report presents findings from an exploratory study by the Regional Psychosocial Support Initiative and Catholic Relief Services’ Support to Replicable, Innovative Village/Community-level Efforts Program of vulnerable youth living in and around Bulawayo, Zimbabwe. It describes their demographic characteristics, exposure to stress and trauma, and psychosocial well-being. The report also highlights the relationships between psychosocial well-being outcomes and exposure to stress and trauma, and the differences in psychosocial well-being between males and females, orphaned and nonorphaned youth, and younger and older adolescents. The report concludes with program and research implications.

Understanding Barriers To Community Participation In Hiv And Aids Services: Summary Report, Population Council, Health Systems Trust

HIV and AIDS

In 2003, South Africa announced its intention to roll out possibly the largest HIV and AIDS treatment program in the world. Much attention is currently focused on supply-side issues, particularly drug procurement and pricing. Far less attention has been paid to demand for and delivery of treatment, care, and support services. Further, although the role of the community and community organizations is articulated in government policy there has been little active engagement with NGOs on the development of these roles or on how to encourage community organizations to support and participate in the antiretroviral (ARV) rollout. This study collected data …

Expanding Pediatric Access To Antiretroviral Therapy In South Africa, Desiree Michaels, Brian Eley, Lewis Ndhlovu, Naomi Rutenberg, Hena Khan

HIV and AIDS

In sub-Saharan Africa, AIDS has become one of the leading causes of death among children under the age of five years. Yet, despite increased availability of antiretroviral therapy (ART), children have been largely ignored or excluded from treatment initiatives. While efforts to get more children on treatment are increasing, important information is lacking to guide program and policy implementation. To address these gaps, the Horizons Program and the University of Cape Town conducted a rapid situational analysis in 2005 of pediatric HIV treatment sites in South Africa. In 2003, the South African government approved a plan for a national HIV …

Context And Dynamics Of Same-Sex Behavior Among Long-Distance Truckers In India: Findings From Qualitative Research, Vaishali Sharma Mahendra, Ravi K. Verma, Pertti J. Pelto, Sarat Chandra Pradhan, Vibha Singh, Asha Rao, Tarun Vij

HIV and AIDS

It is well established that truckers (drivers and helpers) have higher rates of nonmarital sex than any other occupational group. Because of this multipartner sexual activity, truckers form a key group of prevention efforts for HIV and sexually transmitted infections (STIs). Thus far, HIV/STI prevention interventions for truckers have been geared to providing risk-reduction information and services within a heterosexual context. Recent evidence suggests that a significant number of truckers engage in male-to-male (MSM) sexual activity that has implications for HIV/STI transmission. Therefore, information on the nature and extent of MSM activity among these populations is urgently needed for the …

Context And Dynamics Of Male-To-Male Sexual Behavior Of Truckers In India: Findings From A Multi-Site Qualitative Research Study, Ravi K. Verma, Vaishali Sharma Mahendra, Pertti J. Pelto, Sarat Chandra Pradhan, Vibha Singh

HIV and AIDS

It is well established that truckers (drivers and helpers) have higher rates of nonmarital sex than any other occupational group. Because of this multipartner sexual activity, truckers form a key group for HIV/STI prevention efforts. Thus far, HIV/STI prevention interventions for truckers have been geared to providing risk-reduction information and services within a heterosexual context. Recent evidence suggests that a large number of truckers engage in male-to-male (MSM) sexual activity that has serious implications for HIV/STI transmission. Therefore, information on the nature and extent of MSM activity among these populations is urgently needed for the design and implementation of comprehensive …

A Case-Control Study Of Farming And Prostate Cancer In African-American And Caucasian Men, Tamra E. Meyer, Ann L. Coker, Maureen Sanderson, Elaine Symanski

CRVAW Faculty Journal Articles

Objective: To determine the risk of prostate cancer associated with farming by duration, recency and specific activities among African-Americans and Caucasians.

Methods: This population-based case–control study had information on farming-related activities for 405 incident prostate cancer cases and 392 controls matched for age, race and region in South Carolina, USA, from 1999 to 2001. Cases with histologically confirmed, primary invasive prostate cancer who were aged between 65 and 79 years were ascertained through the South Carolina Central Cancer Registry. Appropriately matched controls were identified from the Health Care Financing Administration Medicare Beneficiary File. Data were collected using computer-assisted telephone interviewing, …

Exploring Current Practices In Pediatric Arv Rollout And Integration With Early Childhood Programs In South Africa: A Rapid Situation Analysis, Desiree Michaels, Brian Eley, Lewis Ndhlovu, Naomi Rutenberg

HIV and AIDS

This Horizons program report describes the status of pediatric HIV treatment in selected sites in South Africa, identifies gaps in service delivery, and proposes recommendations for strengthening services and expanding children’s access to treatment. The study provides much needed information on critical issues of pediatric HIV care, especially regarding health service and contextual issues surrounding the expansion of access to treatment for HIV-infected children, and key factors that facilitate sustainability of treatment by young children. The aims of the study were to identify successful program strategies in pediatric HIV treatment in South Africa and to determine priority knowledge gaps to …

Abcs For Hiv Prevention In Kenya: Messages, Beliefs, And Barriers, Julie Pulerwitz, Tiffany Lillie, Louis Apicella, Ann P. Mccauley, Tobey C. Nelson, Simon Ochieng, Peter Mwarogo, Karusa Kiragu, Edward Kunyanga

HIV and AIDS

A great deal of attention has been focused recently on promoting the “ABCs” of HIV prevention— abstinence or delaying sex, being faithful to one sexual partner or reducing the number of sexual partners, and consistently using condoms during sex. Yet even as programs that focus on the ABCs to prevent sexual HIV transmission are rolled out, questions remain about how well different groups in varied cultural contexts understand the terms, as well as how best to address challenges to adopting the ABC behaviors. The Horizons Program and FHI/IMPACT developed a collaborative research study in 2004 to explore how adults and …

'Science Of Trivalency', Kwaku L. Carlisle Woods Rn Md Metd1, Dr. Kwaku L Carlisle Woods Rn Md Metd1

Walden Faculty and Staff Publications

Due to mine cross cultural living, (I was born in the U.S. but grew in Southeast Asia), I became very interested in the Anthological, Social and Scientific difference between cultures. This led to a historical meta evaluation of humanity in general. Using the principals of Noetic Science, this evaluation reviled the ignorance and down right absence of any educational opportunities to learn the true functional abilities of mankind.

Baseline Household Survey: Jhelum District, Pakistan Initiative For Mothers And Newborns (Paiman)

Reproductive Health

The Pakistan Initiative for Mothers and Newborns (PAIMAN) is a five-year project funded by the United States Agency for International Development (USAID). PAIMAN is committed to assisting the Government of Pakistan in implementing the full spectrum of interventions necessary to address maternal and neonatal health issues. USAID has provided a grant to implement PAIMAN in ten districts of Pakistan’s four provinces. The goal of the project is to reduce maternal, newborn, and child mortality. The project calls for a multipronged and integrated strategic approach combining individual health care with public health and community-based interventions. To ensure that success is properly …

Baseline Household Survey: Jaffarabad District, Pakistan Initiative For Mothers And Newborns (Paiman)

Reproductive Health

The Pakistan Initiative for Mothers and Newborns (PAIMAN) is a five-year project funded by the United States Agency for International Development (USAID). PAIMAN is committed to assisting the Government of Pakistan in implementing the full spectrum of interventions necessary to address maternal and neonatal health issues. USAID has provided a grant to implement PAIMAN in ten districts of Pakistan’s four provinces. The goal of the project is to reduce maternal, newborn, and child mortality. The project calls for a multipronged and integrated strategic approach combining individual health care with public health and community-based interventions. To ensure that success is properly …

The Psychological Effects Of Exposure To Wartime Trauma In Bosnian Residents And Refugees: Implications For Treatment And Service Provision, Sandina Begic, Theodore Mcdonald

Public and Population Health Faculty Publications and Presentations

It has been widely reported that exposure to war-related trauma leads to psychological distress in human beings, and it has been hypothesized that this psychological distress may be compounded when people leave their war-torn countries and begin their lives as refugees in a new country. In this study, we explored whether a systematic relationship existed between the level of traumatic wartime events experienced by Bosnian residents and refugees living in the western United States and their levels of post-traumatic stress disorder (PTSD), anxiety, and depression. We also explored whether differences in levels of these mental health problems existed between Bosnian …

Conditions De Travail, De Santé Et De Sécurité Des Travailleurs Du Québec, Michèle Gervais, Paul Massicotte, Danièle Champoux

Rapports de recherche scientifique

Cette analyse des données de l’ESS98 a pour but la recherche d’informations sur les liens potentiels entre la SST et les conditions de travail et d’emploi. L’enquête, menée auprès d’un échantillon (11 000 travailleurs) représentatif de la population québécoise, a fourni un matériel inédit et intéressant sur ces différents aspects ainsi que sur les accidents du travail. Les informations traitées ne tiennent pas compte de la gravité des accidents du travail, seulement de leur fréquence.

On sait que le risque de subir un accident est plus élevé chez les travailleurs manuels en raison des particularités de leurs tâches et de …

Role Modeling Attitudes And Physical Activity Behavior Of Cardiopulmonary Rehabilitation Professionals, Emily Dufrene

Masters Theses

Role models are individuals whose behavior, example or success can be observed and learned from. Health professionals are responsible for the motivation and production of goal directed behavior (Wilson & Petruska, 1984). Modeling behaviors that encourage physical performance, fitness, health, and quality of life should be the foundation for all individuals certified by the American College of Sports Medicine (ACSM Credentialed Professionals, 2005) as exercise specialists, fitness instructors, or program directors. Physicians, exercise physiologists and nurses working in cardiopulmonary rehabilitation programs are expected to model healthy behaviors for their own health benefit and to encourage their patients.

Understanding The Hiv/Sti Prevention Needs Of Men Who Have Sex With Men In Kenya, Washington Onyango-Ouma, Harriet Birungi, Scott Geibel

HIV and AIDS

Understanding the sexual behaviors of populations who are vulnerable to HIV is an important component in the battle against AIDS. Yet policymakers in developing countries, particularly in Africa, have often overlooked men who have sex with men (MSM) as a vulnerable group because of stigmatization of homosexual behavior and denial of the existence of MSM and the role they may play in HIV transmission. A growing body of literature not only documents the presence of this population in Africa but also the importance of reaching them with information and services to prevent HIV and other sexually transmitted infections (STIs). In …