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Decreasing Unwanted Pregnancies By Increasing Use Of Emergency Contraceptive Pills (Ecps): A Leadership Approach, Kara Mcginnis Feb 2011

Decreasing Unwanted Pregnancies By Increasing Use Of Emergency Contraceptive Pills (Ecps): A Leadership Approach, Kara Mcginnis

Florida Public Health Review

Unwanted pregnancies burden the U.S. healthcare system, as well as create challenges for women, families, and children. Emergency contraceptive pills (ECPs) can prevent a large percentage of unwanted pregnancies if used appropriately. Factors contributing to non-use of ECPs include the negative social environment created by views on sexual health, misunderstanding concerning the mechanism ofaction, women’s misperceptions oftheir risks ofgetting pregnant and how ECPs work, barriers to obtaining ECPs, and lack of counseling about ECPs from healthcare providers. Leadership is needed to address these factors contributing to the problem. Health educators are in a unique position to lead the field in …


Detecting Hospital Quality With Pridit., Robert D. Lieberthal, Phd Feb 2011

Detecting Hospital Quality With Pridit., Robert D. Lieberthal, Phd

College of Population Health Lectures, Presentations, Workshops

Presented for the Temple University, Fox School of Business Department of Risk, Insurance & Healthcare Management. Robert A. Hedges Research Seminar Series, Philadelphia, PA.

25 PowerPoint slides

Associated papers available at: http://onlinelibrary.wiley.com/doi/10.1111/j.1475-6773.2007.00821.x/abstract

and the 2008 Proceedings of the Joint Statistical Meeting.


Effet Des Contaminants Sur La Résistance Mécanique Des Gants De Protection : Analyse Préliminaire, Patricia Dolez, Toan Vu-Khanh, Chantal Gauvin, Jaime Lara Feb 2011

Effet Des Contaminants Sur La Résistance Mécanique Des Gants De Protection : Analyse Préliminaire, Patricia Dolez, Toan Vu-Khanh, Chantal Gauvin, Jaime Lara

Rapports de recherche scientifique

Dans de nombreux milieux de travail, comme par exemple l'usinage du métal, la mécanique automobile et la transformation alimentaire, la présence de risques mécaniques se produit souvent de manière simultanée avec celle de divers contaminants industriels, en particulier des huiles et des graisses. Ces composés peuvent éventuellement affecter la résistance des gants aux agresseurs mécaniques. Par ailleurs, certains modèles de gants peuvent subir des traitements de nettoyage afin de prolonger leur durée d'utilisation. Or, ceux-ci peuvent éventuellement provoquer une modification de leurs propriétés.

Cette étude avait pour objectif d'analyser de manière exploratoire trois aspects relatifs à l'effet des conditions réelles …


Étude De La Transmission Sonore À Travers Les Protecteurs Auditifs Et Application D’Une Méthode Pour Évaluer Leur Efficacité En Milieu De Travail. Partie 2 : Étude Préliminaire D’Une Modélisation Par Éléments Finis, Franck Sgard, Hugues Nélisse, Marc-André Gaudreau, Jérôme Boutin, Jérémie Voix, Frédéric Laville Feb 2011

Étude De La Transmission Sonore À Travers Les Protecteurs Auditifs Et Application D’Une Méthode Pour Évaluer Leur Efficacité En Milieu De Travail. Partie 2 : Étude Préliminaire D’Une Modélisation Par Éléments Finis, Franck Sgard, Hugues Nélisse, Marc-André Gaudreau, Jérôme Boutin, Jérémie Voix, Frédéric Laville

Rapports de recherche scientifique

Le projet « Étude de la transmission sonore à travers les protecteurs auditifs et application d'une méthode pour évaluer leur efficacité effective en milieu de travail » comptait principalement deux parties : i) une étude terrain portant sur la mesure de l'efficacité effective des protecteurs auditifs en milieu de travail; ii) une étude exploratoire visant à examiner le potentiel de la modélisation par éléments finis à traiter le problème de la transmission sonore à travers les protecteurs auditifs. Compte tenu de l'ampleur des travaux effectués et de la quantité d'information à présenter, un rapport formé de deux documents distincts est …


Évaluation Des Vibrations Et Du Bruit Des Équipements Miniers, Pierre Marcotte, Sylvain Ouellette, Jérôme Boutin, Gilles Leblanc Feb 2011

Évaluation Des Vibrations Et Du Bruit Des Équipements Miniers, Pierre Marcotte, Sylvain Ouellette, Jérôme Boutin, Gilles Leblanc

Rapports de recherche scientifique

Ce projet visait à identifier les différentes sources vibratoires et sonores parmi une gamme d'équipements miniers pouvant potentiellement avoir un effet néfaste sur la santé des travailleurs. Dans un premier temps, un questionnaire a été distribué à 12 mines souterraines afin de dresser un inventaire des équipements miniers souterrains. De ce nombre, 8 mines ont répondu. Un comité technique a ensuite établi une liste de catégories d'équipement à évaluer en utilisant une grille de décision tenant compte de la sévérité des vibrations, du nombre de travailleurs exposés, de la durée moyenne de l'exposition ainsi que des données disponibles dans la …


Prescriptions For Excellence In Healthcare Winter 2010 Dowload Full Pdf Feb 2011

Prescriptions For Excellence In Healthcare Winter 2010 Dowload Full Pdf

Prescriptions for Excellence in Health Care Newsletter Supplement

No abstract provided.


A Study Of Riders' Noise Exposure On Bay Area Rapid Transit Trains, Alexis Dinno, Cynthia Powell, Margaret Mary King Feb 2011

A Study Of Riders' Noise Exposure On Bay Area Rapid Transit Trains, Alexis Dinno, Cynthia Powell, Margaret Mary King

Community Health Faculty Publications and Presentations

Excessive noise exposure may present a hazard to hearing, cardiovascular and psychosomatic health. Mass transit systems, such as the Bay Area Rapid Transit (BART) system, are potential sources of excessive noise. The purpose of this study was to characterize transit noise and riders' exposure to noise on the BART system using three dosimetry metrics. We made 268 dosimetry measurements on a convenience sample of 51 line segments. Dosimetry measures were modeled using linear and non-linear multiple regression as functions of average velocity, tunnel enclosure, flooring, and wet weather conditions, and presented visually on a map of the BART system. This …


Involvement Of Medical Students And Fresh Medical Graduates Of Karachi, Pakistan In Research, Kiran Ejaz, Muhammad Shahid Shamim, Muhammad Shahzad Shamim, Syed Abid Hussain Feb 2011

Involvement Of Medical Students And Fresh Medical Graduates Of Karachi, Pakistan In Research, Kiran Ejaz, Muhammad Shahid Shamim, Muhammad Shahzad Shamim, Syed Abid Hussain

Department of Emergency Medicine

OBJECTIVE: To study the involvement in research, of final year medical students and fresh graduates of Karachi, Pakistan and to identify the factors influencing their interest in medical research.

METHODS: A cross-sectional, questionnaire based study was conducted in 2007-2008. Five institutes representing the private and public hospitals in the city were selected by cluster sampling. Final year medical students and fresh graduates were included. Descriptive statistics were charted using SPSS v.16 after double data entry.

RESULTS: Out of 378, 186 (49%) participants had journal reading habits due to the requirement of their institution. Mostly, 157 (41%) undergraduates had already participated …


The Association Between Blood Pressure And Years Of Schooling Versus Educational Credentials: Test Of The Sheepskin Effect, Sze Yan Liu, Stephen L. Buka, Crystal D. Linkletter, Ichiro Kawachi, Laura Kubzansky, Eric B. Loucks Feb 2011

The Association Between Blood Pressure And Years Of Schooling Versus Educational Credentials: Test Of The Sheepskin Effect, Sze Yan Liu, Stephen L. Buka, Crystal D. Linkletter, Ichiro Kawachi, Laura Kubzansky, Eric B. Loucks

Department of Public Health Scholarship and Creative Works

Purpose

Attaining a degree may offer greater opportunities for health than years of schooling alone. This study examines whether there is a degree, or “sheepskin”, effect on the association between education and blood pressure.

Methods

Multivariable-adjusted ordinal and linear regression models assessed associations of years of schooling and degree attainment with systolic and diastolic blood pressure in a sample of 552 adults aged 38–47 years.

Results

Years of schooling was inversely associated with systolic blood pressure adjusting for age, gender and race (β=−0.4, 95% CL:−0.7,−0.1 mmHg systolic blood pressure/year of schooling). Additional adjustment for mother’s education, childhood verbal intelligence quotient, …


Cardiorespiratory Fitness And Risk Of Prostate Cancer: Findings From The Aerobics Center Longitudinal Study, Wonwoo Byun, Xuemei Sui, James R. Hébert, Timothy S. Church, I-Min Lee, Charles E. Matthews, Steven N. Blair Feb 2011

Cardiorespiratory Fitness And Risk Of Prostate Cancer: Findings From The Aerobics Center Longitudinal Study, Wonwoo Byun, Xuemei Sui, James R. Hébert, Timothy S. Church, I-Min Lee, Charles E. Matthews, Steven N. Blair

Faculty Publications

Objective - To examine the association between cardiorespiratory (CRF) and risk of incident prostate cancer (PrCA).

Methods - Participants were 19,042 male subjects in the Aerobics Center Longitudinal Study (ACLS), ages 20 to 82 years, who received a baseline medical examination including a maximal treadmill exercise test between 1976 and 2003. CRF levels were defined as low (lowest 20%), moderate (middle 40%), and high (upper 40%) according to age-specific distribution of treadmill duration from the overall ACLS population. PrCA was assessed from responses to mail-back health surveys during 1982 to 2004. Cox proportional hazards regression models, adjusted for potential confounders, …


Effect Of Yoga On Soreness And Torque Loss Following A Doms-Inducing Exercise, Taffy Zghana Hawkins Jan 2011

Effect Of Yoga On Soreness And Torque Loss Following A Doms-Inducing Exercise, Taffy Zghana Hawkins

Student Theses and Dissertations

Research has shown that yoga training and a single bout of yoga decreases delayed onset muscle soreness in the lower extremity. The effect of a single bout of yoga in non-yoga trained individuals following a DOMS-inducing stepping exercise on muscle soreness and torque loss was assessed in this study. Sixteen college-aged females volunteered for this study and were divided into a yoga treatment group and a control group. On the first day of testing the participants completed a VAS, Visual Analog Scale, assessment of pre-exercise pain, and a sit and reach test to measure flexibility. The participants also completed a …


Municipal Solid Waste Collector Dies After Falling From Solid Waste Vehicle Hopper Area, Kentucky Injury Prevention And Research Center Jan 2011

Municipal Solid Waste Collector Dies After Falling From Solid Waste Vehicle Hopper Area, Kentucky Injury Prevention And Research Center

Fatality Case Reports--Motor Vehicle

On a spring day in 2010, a 41 year-old male, solid waste collector, was riding in the hopper area of a solid waste truck when he fell out and struck his head on the pavement. He was riding in the hopper area because the step he usually rode, located at the rear driver side, was broken. Another worker rode the rear step on the passenger side of the vehicle, and a third worker, the driver, drove. After approaching a stop, the driver looked into the rearview mirror and saw the decedent on the pavement. The driver stopped the truck, and …


2011 Report Of The Director Of Public Health - Social Inequalities In Health In Montreal. Progess To Date, Dr. Margaret Chan, World Health Organization Jan 2011

2011 Report Of The Director Of Public Health - Social Inequalities In Health In Montreal. Progess To Date, Dr. Margaret Chan, World Health Organization

Mickey Leland Center Information Portal

In 1998, the Direction de santé publique de Montréal’s first annual report noted a 10-year difference between the average life expectancy of men living in disadvantaged neighbourhoods and of those in wealthy areas. Over a decade has gone by since this first portrait of Montrealers’ state of health was published and it is now time to measure the progress we have made. Therefore, the Director’s 2011 report is focused on social inequalities in health.


Chemotherapy-Induced Cognitive Impairment Is Associated With Decreases In Cell Proliferation And Histone Modifications, Teresita L. Briones, Julie Woods Jan 2011

Chemotherapy-Induced Cognitive Impairment Is Associated With Decreases In Cell Proliferation And Histone Modifications, Teresita L. Briones, Julie Woods

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

In this study, we examined the effects of cyclophosphamide, methothrexate, and 5-Fluorouracil (CMF) drug combination on various aspects of learning and memory. We also examined the effects of CMF on cell proliferation and chromatin remodeling as possible underlying mechanisms to explain chemotherapy-associated cognitive dysfunction. Twenty-four adult female Wistar rats were included in the study and had minimitter implantation for continuous activity monitoring two weeks before the chemotherapy regimen was started. Once baseline activity data were collected, rats were randomly assigned to receive either CMF or saline injections given intraperitoneally. Treatments were given once a week for a total …


Fetal Erap2 Variation Is Associated With Preeclampsia In African Americans In A Case-Control Study, Lori D. Hill, Dashaunda D. Hilliard, Timothy P. York, Sindhu Srinivas, Juan P. Kusanovic, Ricardo Gomez, Michal A. Elovitz, Roberto Romero, Jerome F. Strauss Iii Jan 2011

Fetal Erap2 Variation Is Associated With Preeclampsia In African Americans In A Case-Control Study, Lori D. Hill, Dashaunda D. Hilliard, Timothy P. York, Sindhu Srinivas, Juan P. Kusanovic, Ricardo Gomez, Michal A. Elovitz, Roberto Romero, Jerome F. Strauss Iii

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Preeclampsia affects 3-8% of pregnancies and is a major cause of maternal and perinatal morbidity and mortality worldwide. This complex disorder is characterized by alterations in the immune and vascular systems and involves multiple organs. There is strong evidence for a genetic contribution to preeclampsia. Two different single nucleotide polymorphisms (SNPs) in the endoplasmic reticulum aminopeptidase 2 (ERAP2) gene were recently reported to be associated with increased risk for preeclampsia in two different populations. ERAP2 is expressed in placental tissue and it is involved in immune responses, inflammation, and blood pressure regulation; making it is an attractive preeclampsia …


The Effects Of Culturally Sensitive Education In Driving South Asian Indian Immigrant Women Towards Mammography Screening In New Jersey, Elise Elizabeth Kumar Jan 2011

The Effects Of Culturally Sensitive Education In Driving South Asian Indian Immigrant Women Towards Mammography Screening In New Jersey, Elise Elizabeth Kumar

Theses

Background & Purpose of the Study: Breast Cancer is the most commonly diagnosed form of cancer, and is becoming a major public health issue concern for many South Asian Indian immigrant women. However, women of ethnic subgroups and those who immigrated to the United States within the last ten years are less likely to have had a recent mammogram. The purpose of this study is to evaluate a culturally sensitive breast cancer educational intervention on breast cancer knowledge, perception of cancer fatalism, and improved participation in mammography screening among South Asian Indian immigrant women. Methods: Utilizing a quasi -experimental pretest/post …


Prevalence Of Metabolic Abnormalities In Children With Varying Degrees Of Obesity, Leah Sabato Jan 2011

Prevalence Of Metabolic Abnormalities In Children With Varying Degrees Of Obesity, Leah Sabato

Master of Public Health Program Student Publications

As the prevalence of obesity among children has risen, metabolic syndrome, a cluster of abnormalities which includes obesity, altered glucose metabolism, hypertension, and dyslipidemia, has increasingly become recognized in the pediatric population. Metabolic syndrome has been studied extensively in adults, and there is increasing interest to understand the condition in adolescents; however, studies of metabolic syndrome in younger children are limited. The purpose of this study is to examine the prevalence of metabolic syndrome and its individual components among children aged 6-10 years. Demographic, anthropometric, and biochemical data were gathered retrospectively from the medical records of 222 obese children aged …


Libby Amphibole Contamination In Tree Bark Surrounding Historical Vermiculite Processing Facilities, Mohamedmorgan I. Elashheb, Terry M. Spear, Julie F. Hart, James S. Webber, Tony J. Ward Jan 2011

Libby Amphibole Contamination In Tree Bark Surrounding Historical Vermiculite Processing Facilities, Mohamedmorgan I. Elashheb, Terry M. Spear, Julie F. Hart, James S. Webber, Tony J. Ward

Public and Community Health Sciences Faculty Publications

Over a 70-year period, a mine near Libby, MT supplied nearly 80% of the world’s vermiculite. Raw vermiculite, which was contaminated with naturally occurring amphibole in veins throughout the deposit, was shipped to processing sites throughout the United States for exfoliation. In this pilot study, tree bark samples were collected near processing facili-ties in Spokane, WA, Santa Ana, CA, Newark, CA, and Phoenix, AZ in an effort to determine if areas surrounding these facilities are today contaminated with Libby amphibole asbestos (AA). From areas surrounding each of the four his-torical processing sites, Libby AA was detected in a subset of …


Katrina's Animal Legacy: The Pets Act, Marita Mike, Rebecca Mike, Clark J. Lee Jan 2011

Katrina's Animal Legacy: The Pets Act, Marita Mike, Rebecca Mike, Clark J. Lee

Homeland Security Publications

This article discusses issues related to the federal Pets Evacuation and Transportation Standards Act of 2006 (PETS Act), which was signed into law in the aftermath of Hurricane Katrina. Issues discussed in this article include:

  1. Various problems concerning animal evacuations and sheltering that Hurricane Katrina brought to light;
  2. Provisions of the PETS Act and related laws and policies which were developed in response to the tragedies brought about by Hurricane Katrina; and
  3. Strengths and weaknesses of the PETS Act and recommends next steps to improve implementation of the PETS Act.


Long-Term Effects Of Self-Control On Alcohol Use And Sexual Behavior Among Urban Minority Young Women, Kenneth W. Griffin, Lawrence M. Scheier, Bianca Acevedo, Jerry L. Grenard, Gilbert J. Botvin Jan 2011

Long-Term Effects Of Self-Control On Alcohol Use And Sexual Behavior Among Urban Minority Young Women, Kenneth W. Griffin, Lawrence M. Scheier, Bianca Acevedo, Jerry L. Grenard, Gilbert J. Botvin

CGU Faculty Publications and Research

High risk alcohol use and sexual behaviors peak in young adulthood and often occur in the same individuals. Alcohol use has been found to impair decision-making and contribute to high risk sexual activity. However, the association between alcohol use and risky sexual behavior may also reflect enduring individual differences in risk taking, sociability, self-control, and related variables. Both behaviors can serve similar functions related to recreation, interpersonal connection, and the pursuit of excitement or pleasure. The present study examined the extent to which high risk drinking and sexual behavior clustered together in a sample of urban minority young adult women, …


Preliminary Report On Patent Literature, Search Methodology And Patent Status Of Medicines On The Who Eml 2009, Jon R. Cavicchi, Stanley P. Kowalski Jan 2011

Preliminary Report On Patent Literature, Search Methodology And Patent Status Of Medicines On The Who Eml 2009, Jon R. Cavicchi, Stanley P. Kowalski

Law Faculty Scholarship

Over the past several decades the World Health Organization (WHO) has produced the Essential Medicines List (EML) to assist countries in deciding what medicines should be essential and available in National Essential Medicine Lists.1 WHO, through the work of regional offices, supports nations using the EML to ensure the quality, availability, and affordability of pharmaceuticals required to promote and advance public health in nations across the globe. However in some cases, access to EML pharmaceuticals might be complicated by existing patents, i.e., where issued, patent rights might pose obstacles to access and inclusion in national EMLs. Indeed, in developed and …


An Examination Of Ohio’S Physical Education Academic Content Standard 4, Benchmark A For Grades 9-12, Gabriel Jones Jan 2011

An Examination Of Ohio’S Physical Education Academic Content Standard 4, Benchmark A For Grades 9-12, Gabriel Jones

Master of Public Health Program Student Publications

Objective: The purpose of this study was to describe select physical education teachers’ perceptions of the effectiveness and accuracy of the assessments for Ohio's Physical Education Academic Content Standard 4 Benchmark A in determining the fitness and physical activity levels of high school students. A secondary purpose was to describe the fitness levels of high school physical education students, based on assessment data.

Methods: Participants were forty-one physical education teachers and ninety high school students from southwest Ohio. Data were collected from the teachers through an online questionnaire and from students with FITNESSGRAM testing. FITNESSGRAM data from one local school …


Assessment And Management Of Adult Obesity In A Primary Care Practice, Sherry M. Adkins Jan 2011

Assessment And Management Of Adult Obesity In A Primary Care Practice, Sherry M. Adkins

Master of Public Health Program Student Publications

Purpose: The purpose of this project was to describe primary care physician adherence to National Heart Lung and Blood Institute (NHLBI) Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults (1998) and to explore patient characteristics associated with physician assessment and management behaviors. Patient characteristics included age, sex, race, BMI, associated disease risk, and Medicaid coverage.

Methods: A chart abstraction of 99 randomly selected adult patients with at least one visit to a particular primary care practice during a 12-month period was completed. Patients were not pregnant during the year of review, and had a …


Ic107: Cancer Facts: Workplace And Cancer, Intercultural Cancer Council Jan 2011

Ic107: Cancer Facts: Workplace And Cancer, Intercultural Cancer Council

Informational and Promotional Materials

The fact sheet summarizes cancer facts related to the workplace. The document is organized into seven sections: Who We Are, Causes/Etiology, Patient/Provider Communication, Screening, Disparities, Outcomes, and References. See more at Intercultural Cancer Council Records.


Action Anthropology And Pedagogy: University-Community Collaborations In Setting Policy, Lutchmie Narine, Sandra D. Lane, Robert A. Rubinstein, Inga Back, Caitlin Cornell, Alexander Hodgens, Monique Brantley, Rachel Kramas, Kathleen Keough, Brandon O'Connor, William Suk, Eric Morrissette, Mary Benson Jan 2011

Action Anthropology And Pedagogy: University-Community Collaborations In Setting Policy, Lutchmie Narine, Sandra D. Lane, Robert A. Rubinstein, Inga Back, Caitlin Cornell, Alexander Hodgens, Monique Brantley, Rachel Kramas, Kathleen Keough, Brandon O'Connor, William Suk, Eric Morrissette, Mary Benson

Public Health, Food Studies, and Nutrition

This article describes a student-led, community-participatory project focused on reducing the burden of childhood lead poisoning in rental housing. A multidisciplinary group of students and faculty worked with community members. We compiled the social, public health, economic, and policy information on the human and fiscal costs of childhood lead poisoning. This analysis was done for community advocates to use to persuade policymakers to enact a local law strengthening the prevention of childhood lead poisoning in rental property. In conducting this work, the students gained experience in qualitative research methods, quantitative data analysis, the health consequences of lead exposure, health policy, …


The Shaping Of Modern Human Immune Systems By Multiregional Admixture With Archaic Humans, Laurent Abi-Rached, Matthew J. Jobin, Subhash Kulkarni, Alasdair Mcwhinnie, Klara Dalva, Loren Gragert, Farbod Babrzadeh, Baback Gharizadeh, Ma Luo, Francis A. Plummer, Joshua Kimani, Mary Carrington, Derek Middleton, Raja Rajalingam, Meral Beksac, Steven G. E. Marsh, Martin Maiers, Lisbeth A. Guethlein, Sofia Tavoularis, Ann-Margaret Little, Richard E. Green, Paul J. Norman, Peter Parham Jan 2011

The Shaping Of Modern Human Immune Systems By Multiregional Admixture With Archaic Humans, Laurent Abi-Rached, Matthew J. Jobin, Subhash Kulkarni, Alasdair Mcwhinnie, Klara Dalva, Loren Gragert, Farbod Babrzadeh, Baback Gharizadeh, Ma Luo, Francis A. Plummer, Joshua Kimani, Mary Carrington, Derek Middleton, Raja Rajalingam, Meral Beksac, Steven G. E. Marsh, Martin Maiers, Lisbeth A. Guethlein, Sofia Tavoularis, Ann-Margaret Little, Richard E. Green, Paul J. Norman, Peter Parham

United States Public Health Resources

Whole genome comparisons identified introgression from archaic to modern humans. Our analysis of highly polymorphic HLA class I, vital immune system components subject to strong balancing selection, shows how modern humans acquired the HLA-B*73 allele in west Asia through admixture with archaic humans called Denisovans, a likely sister group to the Neandertals. Virtual genotyping of Denisovan and Neandertal genomes identified archaic HLA haplotypes carrying functionally distinctive alleles that have introgressed into modern Eurasian and Oceanian populations. These alleles, of which several encode unique or strong ligands for natural killer cell receptors, now represent more than half the HLA alleles of …


Factors Associated With Viral Rebound In Hiv-1-Infected Individuals Enrolled In A Therapeutic Hiv-1 Gag Vaccine Trial, Jonathan Z. Li, Zabrina L. Brumme, Chanson J. Brumme, Hongying Wang, John Spritzler, Michael N. Robertson, Michael M. Lederman, Mary Carrington, Bruce D. Walker, Rovert T. Schooley, Daniel R. Kuritzkes Jan 2011

Factors Associated With Viral Rebound In Hiv-1-Infected Individuals Enrolled In A Therapeutic Hiv-1 Gag Vaccine Trial, Jonathan Z. Li, Zabrina L. Brumme, Chanson J. Brumme, Hongying Wang, John Spritzler, Michael N. Robertson, Michael M. Lederman, Mary Carrington, Bruce D. Walker, Rovert T. Schooley, Daniel R. Kuritzkes

United States Public Health Resources

Background. Human immunodeficiency virus type 1 (HIV-1) vaccines directed to the cell-mediated immune system could have a role in lowering the plasma HIV-1 RNA set point, which may reduce infectivity and delay disease progression.

Methods. Randomized, placebo-controlled trial involving HIV-1-infected participants who received a recombinant adenovirus serotype 5 (rAd5) HIV-1 gag vaccine or placebo. Sequence-based HLA typing was performed for all 110 participants who initiated analytic treatment interruption (ATI) to assess the role of HLA types previously associated with HIV prognosis. Plasma HIV-1 gag and pol RNA sequences were obtained during the ATI. Virologic endpoints and HLA groups …


Human Leukocyte Antigen Genotype And Risk Of Hiv Disease Progression Before And After Initiation Of Antiretroviral Therapy, Mark H. Kuniholm, Xiaojiang Gao, Andrea Kovacs, Kathryn Anastos, Darlene Marti, Ruth M. Greenblatt, Mardge H. Cohen, Howard Minkoff, Stephen J. Gange, Melissa Fazzari, Mary A. Young, Howard D. Strickler, Mary Carrington Jan 2011

Human Leukocyte Antigen Genotype And Risk Of Hiv Disease Progression Before And After Initiation Of Antiretroviral Therapy, Mark H. Kuniholm, Xiaojiang Gao, Andrea Kovacs, Kathryn Anastos, Darlene Marti, Ruth M. Greenblatt, Mardge H. Cohen, Howard Minkoff, Stephen J. Gange, Melissa Fazzari, Mary A. Young, Howard D. Strickler, Mary Carrington

United States Public Health Resources

While the human leukocyte antigen (HLA) genotype has been associated with the rate of HIV disease progression in untreated patients, little is known regarding these relationships in patients using highly active antiretroviral therapy (HAART). The limited data reported to date identified few HLA-HIV disease associations in patients using HAART and even occasional associations that were opposite of those found in untreated patients. We conducted high-resolution HLA class I and II genotyping in a random sample (n = 860) of HIV-seropositive women enrolled in a long-term cohort initiated in 1994. HLA-HIV disease associations before and after initiation of HAART were examined …


Hiv-1 Adaptation To Nk-Cell-Mediated Immune Pressure, Galit Alter, David Heckerman, Arne Schneidewind, Lena Fadda, Carl M. Kadie, Jonathan M. Carlson, Cesar Oniangue-Ndza, Maureen Martin, Bin Li, Salim I. Khakoo, Mary Carrington, Todd M. Allen, Marcus Altfeld Jan 2011

Hiv-1 Adaptation To Nk-Cell-Mediated Immune Pressure, Galit Alter, David Heckerman, Arne Schneidewind, Lena Fadda, Carl M. Kadie, Jonathan M. Carlson, Cesar Oniangue-Ndza, Maureen Martin, Bin Li, Salim I. Khakoo, Mary Carrington, Todd M. Allen, Marcus Altfeld

United States Public Health Resources

Natural killer (NK) cells have an important role in the control of viral infections, recognizing virally infected cells through a variety of activating and inhibitory receptors. Epidemiological and functional studies have recently suggested that NK cells can also contribute to the control of HIV-1 infection through recognition of virally infected cells by both activating and inhibitory killer immunoglobulin-like receptors (KIRs). However, it remains unknown whether NK cells can directly mediate antiviral immune pressure in vivo in humans. Here we describe KIR-associated amino-acid polymorphisms in the HIV-1 sequence of chronically infected individuals, on a population level. We show that these KIR-associated …


Hla-A*3101 And Carbamazepine-Induced Hypersensitivity Reactions In Europeans, Mark Mccormack, Ana Alfirevic, Stephane Bourgeois, John J. Farrell, Dalia Kasperavičiūtė, Mary Carrington, Graeme J. Sills, Tony Marson, Xiaoming Jia, Paul I. W. De Bakker, Krishna Chinthapalli, Mariam Molokhia, Michael R. Johnson, Gerard D. O'Connor, Elijah Chaila, Saud Alhusaini, B. Kevin Park, Chantal Depondt, Sanjay M. Sisodiya, David B. Goldstein, Panos Deloukas, Norman Delanty, Gianpiero L. Cavalleri, Munir Pirmohamed, Werner Pichler, Kevin V. Shianna, Rodney A. Radtke, Massimo Pandolfo Jan 2011

Hla-A*3101 And Carbamazepine-Induced Hypersensitivity Reactions In Europeans, Mark Mccormack, Ana Alfirevic, Stephane Bourgeois, John J. Farrell, Dalia Kasperavičiūtė, Mary Carrington, Graeme J. Sills, Tony Marson, Xiaoming Jia, Paul I. W. De Bakker, Krishna Chinthapalli, Mariam Molokhia, Michael R. Johnson, Gerard D. O'Connor, Elijah Chaila, Saud Alhusaini, B. Kevin Park, Chantal Depondt, Sanjay M. Sisodiya, David B. Goldstein, Panos Deloukas, Norman Delanty, Gianpiero L. Cavalleri, Munir Pirmohamed, Werner Pichler, Kevin V. Shianna, Rodney A. Radtke, Massimo Pandolfo

United States Public Health Resources

Background

Carbamazepine causes various forms of hypersensitivity reactions, ranging from maculopapular exanthema to severe blistering reactions. The HLA-B*1502 allele has been shown to be strongly correlated with carbamazepine-induced Stevens–Johnson syndrome and toxic epidermal necrolysis (SJS–TEN) in the Han Chinese and other Asian populations but not in European populations.

Methods

We performed a genomewide association study of samples obtained from 22 subjects with carbamazepine-induced hypersensitivity syndrome, 43 subjects with carbamazepine- induced maculopapular exanthema, and 3987 control subjects, all of European descent. We tested for an association between disease and HLA alleles through proxy single-nucleotide polymorphisms and imputation, confirming associations by high-resolution …