Digital Commons Network^™

Microsphere Core Technology Boosts Innovation Of Biopharmaceutical Industry Chain, Jie Wu, Weiqing Zhou, Lan Zhao, Guanghui Ma

Bulletin of Chinese Academy of Sciences (Chinese Version)

Advancements in life science and biotechnology have boosted the evolution of the biopharmaceutical industry with the continual emergence of biomedical products for disease prevention, diagnosis, and treatment. Microspheres, as crucial functional materials, play a significant role in the discovery, preparation, separation, and delivery of biological drugs due to their flexible size, morphology, structure, and function. This study reviews recent significant advancements in microspheres and their applications in cell culture, chromatographic separation, drug delivery, and as vaccine adjuvants. Additionally, it proposes future trends for the development of microspheres.

Research Progress In High-Throughput Phenotype Testing Technology And Equipment For Engineering Cells Based On Microfluidics, Shuang Li, Xiaojie Guo, Haibo Chen, Sisi Chen, Xin Da, Zhenghui Li, Qinxiu Liu, Yi Wang, Xinhui Xing, Chong Zhang

Bulletin of Chinese Academy of Sciences (Chinese Version)

Engineering cells are a core component of green bio-manufacturing. The efficient testing and acquisition of engineering cells with the desired phenotype is a critical factor in the successful implementation of bio-manufacturing. In recent years, based on microfluidics technologies, non-culture type single-cell phenotype high-throughput test equipment and culture type phenotype high-throughput test equipment for the growth and metabolism of single cell in a bioreactor have been developed such as microdroplet and microchamber, realizing high-throughput, automated, miniaturized, and integrated testing of the phenotypes of engineering cells and providing a powerful tool for the breeding of engineering cells. This review systematically compiles the …

Strengthen Research On Environmental Control Technologies And Management Policies For Emerging Contaminants In China, Ying Ma, Xiang Li, Yongming Luo

Bulletin of Chinese Academy of Sciences (Chinese Version)

The prevention and management of emerging contaminants (ECs) have become critical measures in China’s battle against environmental pollution. This study focuses on the environmental control technologies and policy governance related to emerging contaminants (ECs), analyzing their environmental pathways and challenges to public health, and highlighting advancements and limitations in current physical, chemical, and biological control technologies. Based on a comprehensive analysis of international policies and regulations on ECs control, the study identifies existing challenges and shortcomings in domestic management. Recommendations are proposed to enhance research on environmental control technologies and policies for ECs in China, aiming to provide insights for …

Analysis On Development Status And Characteristics Of Non-Governmental Bio-Safety And Bio-Security Think Tanks In The United States, Wenbing Ma, Qiang Song, Lei Wang

Bulletin of Chinese Academy of Sciences (Chinese Version)

At present, the complexity of bio-safety governance is becoming increasingly prominent, and complex issues such as security and development in the bio-economy, preparedness and response to infectious disease pandemics, the interweaving and integration of bio-security and other security factors, and the integration of scientific and technological factors and security factors urgently require think tanks to conduct systematic, comprehensive and forward-looking assessments and provide professional solutions. Rooted in the relatively mature experience in the construction of think tanks in the United States, a number of bio-safety and bio-security think tanks with greater influence have been developed, which have acted as an …

Large Model-Driven, Human-Computer Collaborative Robotic Ai-Chemist Cloud Facility, Yuanyuan Chong, Shuo Feng, Song Wang, Jun Jiang

Bulletin of Chinese Academy of Sciences (Chinese Version)

At present, chemical science is facing unprecedented opportunities and challenges due to the technological changes brought by artificial intelligence. In order to promote the paradigm shift in chemical research, this study proposes the construction plan of the robotic AI-chemist cloud facility. This system realizes a new paradigm of scientific research by collecting multi-channel data to build a database, developing large scientific models enhanced by chemical knowledge, constructing clusters of robotic facilities, and building an intelligent management decision system, which will dramatically improve the efficiency of scientific research and solve scientific problems in terminal applications. This infrastructure is expected to change …

A New Paradigm Of Life Science Research Driven By Artificial Intelligence, Xin Li, Hanchao Yu

Bulletin of Chinese Academy of Sciences (Chinese Version)

The rapid development of biotechnology and information technology has brought life sciences into a new era of data explosion. The traditional life science research paradigm struggles to reveal the fundamental rules of complex biological systems from rapidly growing biological big data. As artificial intelligence continues to achieve disruptive breakthroughs in life science, a new paradigm driven by AI is emerging. This study delves into typical examples of life science research driven by AI, proposes the concept and key elements of the new life science research paradigm, elaborates on the cutting-edge of life science research under this new paradigm, and discusses …

Research On Science And Technology Innovation Strategy And Policy System: “3+5” Analytical Framework, Jiaofeng Pan, Zihao He, Xiao Lu

Bulletin of Chinese Academy of Sciences (Chinese Version)

As an important means of promoting national scientific and technological development, S&T innovation strategy and policy are advancing towards a multidimensional “synergy” among S&T, the economy, society, and the environment, and they need to encompass many internal and external elements of S&T system. Accordingly, an overall S&T policy framework covering key elements and relevant interactions should be constructed. This study proposes “3+5” analytical framework for S&T innovation strategy and policy. Specifically, (1) this study defines the conceptual connotation of “3+5” framework, and puts forward the “design layer” including guiding strategy, planning layout, and institutional arrangement, and the “construction layer” including …

Review On Reform Of International Research Evaluation In Past Decade, Fang Xu, Xiaoxuan Li

Bulletin of Chinese Academy of Sciences (Chinese Version)

In May 2013, with the release of the San Francisco Declaration on Research Assessment (DORA) as a symbol, the reform of international research evaluation began. Over the past decade, the reform of international research evaluation has undergone extensive theoretical preparation and initiatives, and is now moving towards practice. More than 350 institutions from over 40 countries have signed agreements to reform research evaluation and carried out pilot reforms, with initial results. This study systematically summarizes and analyzes the ten-year reform of international research evaluation in three aspects: reform goals, measures, and cases. From the perspective of comparing with China’s research …

Ai For Science: Ai Enabled Scientific Facility Transforms Fundamental Research, Xiaokang Yang, Yanyan Xu, Lu Chen, Yunbo Wang, Yue Gao, Jidong Tian, Kai Yu, Yaohui Jin, Hong Mei

Bulletin of Chinese Academy of Sciences (Chinese Version)

In recent years, artificial intelligence (AI) has achieved numerous disruptive breakthroughs in frontier scientific and technological fields, such as AlphaFold2 for protein structure prediction, intelligent control of nuclear fusion, and drug design for COVID-19. These achievements indicate that AI for Science is becoming a new paradigm in research. To achieve fundamental scientific innovation and major technological breakthroughs in the era of intelligence, two core issues should be addressed: 1) how to harness the generality and creativity of the new-generation of AI, especially generative AI and large language models (LLMs), to promote the formation of new paradigms; 2) how to empower …

Analysis And Enlightenment Of International Policy Trends In Basic Research, Minzhuo Huang, Jinglei Wu, Zhen Ren, Qingfeng Meng

Bulletin of Chinese Academy of Sciences (Chinese Version)

As the intensity of international competition in science and technology continues to escalate, basic research has taken center stage in the strategic planning of countries worldwide. To address the challenges of the new era, major countries have evaluated the essence of basic research, as well as its positioning within national innovation systems, and are continuously explored innovative funding models. Based on monitoring and analysis of the latest policy developments in foreign basic research in 2022, and on the basis of analysis and data mining, this study comprehensively evaluates the policy trends and future directions of basic research in major countries. …

Legal, Policy, And Environmental Scholars Discuss Global Food Systems At Indiana Law Symposium, James Owsley Boyd

Keep Up With the Latest News from the Law School (blog)

The Indiana University Maurer School of Law and its Indiana Journal of Global Legal Studies are hosting scholars from around the country Friday and Saturday (Jan. 19-20) for an interdisciplinary discussion on one of the world’s most prevalent problems—food insecurity.

Data from the World Bank estimate more than 780 million people around the world suffered from chronic hunger in 2022. As climate change affects agricultural production and water accessibility, the problem could worsen in coming years.

“A Fragile Framework: How Global Food Systems Intersect with the International Legal Order, the Environment, and the World’s Populations” will bring together legal, policy, …

Pilot Implementation Of A Nutrition-Focused Community-Health-Worker Intervention Among Formerly Chronically Homeless Adults In Permanent Supportive Housing, Jane E Hamilton, Diana C Guevara, Sara F Steinfeld, Raina Jose, Farrah Hmaidan, Sarah Simmons, Calvin W Wong, Clara Smith, Eva Thibaudeau-Graczyk, Shreela V Sharma

Faculty, Staff and Student Publications

Food insecurity is a known health equity threat for formerly chronically homeless populations even after they transition into permanent housing. This project utilized a human-centered design methodology to plan and implement a nutrition-focused community-health-worker (CHW) intervention in permanent supportive housing (PSH). The project aimed to increase access to healthy foods, improve nutritional literacy, healthy cooking/eating practices, and build community/social connectedness among 140 PSH residents. Validated food-security screening conducted by CHWs identified low or very low food security among 64% of 83 residents who completed the baseline survey, which is similar to rates found in a previous study among formerly homeless …

Graying Incarcerated Persons And Education Programs In Nigerian Correctional Centre, Ijeoma B. Uche Phd, Agnes E. Okafor Phd, Okala A. Uche Phd *Corresponding Author

Journal of Prison Education Research

Correctional education programs are rehabilitation programs designed for incarcerated persons in Nigerian correctional institutions. However, getting the graying incarcerated persons to participate in education programs becomes quite challenging. This study investigates graying incarcerated persons and education programs in one correctional centre. Data were collected qualitatively from fifteen (15) incarcerated individuals aged 60 years and above using semi-structured interviews. Thematic analysis was employed in analyzing the data generated for the study. Findings show that there are no available education programs for graying incarcerated individuals. The study also revealed that designing education programs in such a way that it will accommodate the …

The Repeal Of Net Neutrality And Impact On Consumer Internet Access Rights, Ashlie Gibbs

Walden Dissertations and Doctoral Studies

No abstract provided.

Effects Of Public Policy On Family Planning For Millennial Women In The United States, Rachel Marie Cole

Walden Dissertations and Doctoral Studies

No abstract provided.

Waiving Snap Interviews During The Covid-19 Pandemic Increased Snap Caseloads, Colleen Heflin, William Clay Fannin, Leonard M. Lopoo, Siobhan O'Keefe

Center for Policy Research

Food insecurity in the United States reached historically high rates during the COVID-19 pandemic, thus substantially increasing demand for the Supplemental Nutrition Assistance Program (SNAP). To facilitate access to SNAP during the pandemic, the federal government granted state SNAP offices the option to waive the interview requirement – an administrative burden associated with the SNAP certification process. This brief summarizes findings from a recent study that used data from SNAP offices across 10 states to examine the impact of SNAP interview waivers on SNAP caseloads from January 5th to April 30th of 2021. Findings reveal that counties that implemented the …

Fire Department Personnel Perspectives On Avoidable Emergency Medical Services Calls And Emergency Department Visits, Nathanial Render

Walden Dissertations and Doctoral Studies

No abstract provided.

Minority Small Business Owner Perceptions Of Coronavirus Policies In Metropolitan Washington, Dc, Amara Omar Kuyateh

Walden Dissertations and Doctoral Studies

No abstract provided.

Competency-Based Personnel Selection Oklahoma - Site Intervention Logic Model, Quality Improvement Center For Workforce Development (Qic-Wd)

Intervention Summaries

Each QIC-WD site developed a logic model to serve as a visual representation of their selected intervention. All logic models included four main components: inputs, activities, outputs, and outcomes. Collectively, these demonstrate the resources and actions required to implement the program, as well as the associated result or changes anticipated through implementation of the program. The hypothesized relationships are represented by the pathways connecting the listed activities and anticipated outcomes. For more information see Site Overview.

Competency-Based Personnel Selection Oklahoma - Evaluation Overview, Quality Improvement Center For Workforce Development (Qic-Wd)

Intervention Summaries

The QIC-WD evaluation was conducted with the support of the Oklahoma Human Services (OKDHS) to determine if a Competency-based Personnel Selection process was effective in improving workforce and child welfare outcomes.

Research Questions

The primary research questions concerned the ability of the structured hiring tools to predict job performance, tenure, and turnover. It was hypothesized that the use of the standardized hiring process would result in the selection of candidates who performed better and had lower rates of turnover and longer tenure than candidates hired using existing selection processes, see Logic Model. Intermediate outcomes examined included employee feelings of …

Competency-Based Personnel Selection Oklahoma - Theory Of Change, Quality Improvement Center For Workforce Development (Qic-Wd)

Intervention Summaries

During the needs assessment process three areas of opportunity were discussed for possible intervention at the Oklahoma Human Services (OKDHS) Division of Child Welfare Services:

1. hiring of new workers,
2. promotion decisions for lead worker and supervisor positions, and
3. staff recognition and rewards.

Ultimately, one theory of change was developed to step through the “if, then” logic for implementation of a standardized hiring process to improve worker retention and performance.

The theory of change development process was informed by various data examined throughout the needs assessment, input from the Oklahoma QIC-WD Steering Committee, and relevant research and best practice for …

Competency-Based Personnel Selection Oklahoma - Implementation Overview, Quality Improvement Center For Workforce Development (Qic-Wd)

Intervention Summaries

The Implementation Team

The QIC-WD worked with Oklahoma Human Services (OKDHS) Division of Child Welfare Services to establish a team to lead the development and implementation of their competency-based personnel selection intervention. The implementation team was called the Oklahoma QIC-WD Steering Committee. It included a Programs Analyst from each of the five geographic regions of the state and one from the Foster Care and Adoptions program, the Site Implementation Manager (SIM), the Data Coordinator, project sponsor (Deputy Director), representatives from Human Resources, training partners within OKDHS and from University of Oklahoma Center for Public Management, and three members of …

Competency-Based Personnel Selection Oklahoma - Implementation Overview, Quality Improvement Center For Workforce Development (Qic-Wd)

Other QIC-WD Products

The Implementation Team

The QIC-WD worked with Oklahoma Human Services (OKDHS) Division of Child Welfare Services to establish a team to lead the development and implementation of their competency-based personnel selection intervention. The implementation team was called the Oklahoma QIC-WD Steering Committee. It included a Programs Analyst from each of the five geographic regions of the state and one from the Foster Care and Adoptions program, the Site Implementation Manager (SIM), the Data Coordinator, project sponsor (Deputy Director), representatives from Human Resources, training partners within OKDHS and from University of Oklahoma Center for Public Management, and three members of …

The Million Veteran Program 1990-1991 Gulf War Era Survey: An Evaluation Of Veteran Response, Characteristics, And Representativeness Of The Gulf War Era Veteran Population, Kelly M Harrington, Rachel Quaden, Lea Steele, Drew A Helmer, Elizabeth R Hauser, Sarah T Ahmed, Mihaela Aslan, Krishnan Radhakrishnan, Jacqueline Honerlaw, Xuan-Mai T Nguyen, Sumitra Muralidhar, John Concato, Kelly Cho, J Michael Gaziano, Stacey B Whitbourne, On Behalf Of The Va Million Veteran Program

Center for Medical Ethics and Health Policy Staff Publications

To address gaps in understanding the pathophysiology of Gulf War Illness (GWI), the VA Million Veteran Program (MVP) developed and implemented a survey to MVP enrollees who served in the U.S. military during the 1990–1991 Persian Gulf War (GW). Eligible Veterans were invited via mail to complete a survey assessing health conditions as well as GW-specific deployment characteristics and exposures. We evaluated the representativeness of this GW-era cohort relative to the broader population by comparing demographic, military, and health characteristics between respondents and non-respondents, as well as with all GW-era Veterans who have used Veterans Health Administration (VHA) services and …

Budget Capping Health Care: Its Impact On Health, Susan Chen

Theses and Dissertations

The goal of a budget cap on healthcare is to constrain total healthcare expenditure without compromising quality. This paper examines the impacts of budget capping on health and behavioral health outcomes, exploiting the completed Maryland All-Payer Model and the ongoing, extensional Maryland Total Cost of Care model, both of which capped healthcare budgets in Maryland. I use data from 2011-2021 surveys of the Behavioral Risk Factor Surveillance system and generalized difference-in-difference regression models to find that budget capping improves health and behavioral health outcomes with a greater favorable effect during the Maryland Total Cost of Care model.

Supportive Supervision And Resiliency Ohio - Accwic Coaching Curriculum, Quality Improvement Center For Workforce Development (Qic-Wd)

Intervention Summaries

No abstract provided.

Supportive Supervision And Resiliency Ohio - Accwic Training Curriculum, Quality Improvement Center For Workforce Development (Qic-Wd)

Intervention Summaries

No abstract provided.

Supportive Supervision And Resiliency Ohio - Resilience Alliance Facilitator Manual, Quality Improvement Center For Workforce Development (Qic-Wd)

Intervention Summaries

No abstract provided.

Supportive Supervision And Resiliency Ohio - Resilience Alliance Participant Handbook, Quality Improvement Center For Workforce Development (Qic-Wd)

Intervention Summaries

No abstract provided.

Supportive Supervision And Resiliency Ohio - Coaching In Child Welfare 2019 Participant Guide, Quality Improvement Center For Workforce Development (Qic-Wd)

Intervention Summaries

No abstract provided.