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Supreme Court Gives States The Green Light To Go Ham: The Dormant Commerce Clause In Renewable Energy In Light Of National Pork Producers, Ellie Carl Apr 2025

Supreme Court Gives States The Green Light To Go Ham: The Dormant Commerce Clause In Renewable Energy In Light Of National Pork Producers, Ellie Carl

Michigan Journal of Environmental & Administrative Law

Two years ago, the Supreme Court slaughtered the Dormant Commerce Clause in its decision in National Pork Producers v. Ross. While the case is not explicitly about environmental law, it significantly affects environmental laws and policies, especially pertaining to state renewable portfolio standards. These state policies are especially prone to Dormant Commerce Clause litigation, given the interstate nature of electric grids. This paper argues that the scope of the Dormant Commerce Clause in light of this decision is appropriate for ensuring that states have adequate wiggle room in renewable energy regulation, but not an excessive amount of leeway so …


Aging In Somerville: A Community Needs Assessment, Ceara Somerville, Caitlin E. Coyle Apr 2025

Aging In Somerville: A Community Needs Assessment, Ceara Somerville, Caitlin E. Coyle

Center for Social and Demographic Research on Aging Publications

This report describes research undertaken by the Center for Social & Demographic Research on Aging (CSDRA) within the Gerontology Institute at the University of Massachusetts Boston, on behalf of the City of Somerville. The goals of this project were to investigate the needs, interests, preferences, and opinions of Somerville residents age 60 or older by engaging the community regarding their experiences and needs relevant to the Council on Aging’s (COA’s) objective to identify and serve the needs of all Somerville citizens 60 and older.


Does Name, Image, And Likeness Increase Gender Inequality In College Athletics?, Aimee Christenson Apr 2025

Does Name, Image, And Likeness Increase Gender Inequality In College Athletics?, Aimee Christenson

Political Science Theses and Capstones

In June of 2021, the National Collegiate Athletic Association adopted its first interim policy regarding Name, Image, and Likeness. From here, college athletes have been able to benefit from opportunities regarding their brand as an athlete. While this development has been historic in its expansion of rights to athletes, it highlights the inequities between male and female athletes. Title IX requires equal opportunity for male and female students. This research raises questions about whether NIL is increasing the disparity between male and female athletes. To answer this question, I looked at NIL data collected by Kyle Ems on the NIL …


Missourians’ Opinions And Behavioral Changes After The Overturning Of Roe V. Wade, Rana Jordan, Hisako Matsuo Apr 2025

Missourians’ Opinions And Behavioral Changes After The Overturning Of Roe V. Wade, Rana Jordan, Hisako Matsuo

Missouri Policy Journal

The recent overturning of Roe v. Wade and the rise in restrictive abortion laws across the United States has caused a division across all communities, including citizens, politicians, and healthcare providers. The aim of this study was to learn the opinions and behavioral changes of birthing people since the overturning of Roe. This study utilized a cross-sectional online survey to explore the opinions and behavioral changes of birthing people after the overturning of Roe. The survey instrument covered the opinions and behavioral changes of Americans regarding abortion access, birth control access, willingness to share information with healthcare provider(s), and use …


Restoring Trust: What The Missouri Supreme Court And Andragogy Can Teach The United States Supreme Court, Grant J. Shostak Apr 2025

Restoring Trust: What The Missouri Supreme Court And Andragogy Can Teach The United States Supreme Court, Grant J. Shostak

Missouri Policy Journal

Confidence in the United States Supreme Court has reached an all-time low. Efforts by the Court to restore confidence, such as making a statement concerning ethics and adopting a non-binding code of conduct, seem ineffectual in restoring confidence. Andragogy, the art and science of teaching adults, may prove useful in helping to restore confidence in the Supreme Court. As the Supreme Court educates adults through its decisions, it may utilize and adapt andragogical concepts within the confines of the judicial setting to help restore confidence in its decisions and operations. The Missouri Supreme Court has implemented a number of andragogically-consistent …


Reserve Officer Training Corps Officers’ Perspectives On Diversity, Equity, And Inclusionary Practices In Commissioning Minority Officers In The U.S. Military, Christopher Tompkins Apr 2025

Reserve Officer Training Corps Officers’ Perspectives On Diversity, Equity, And Inclusionary Practices In Commissioning Minority Officers In The U.S. Military, Christopher Tompkins

Walden Dissertations and Doctoral Studies

The problem addressed in this study was the lack of research on Reserve Officer Training Corps (ROTC) officers’ practices using diversity, equity, and inclusionary (DEI) in commissioning minority officers in the U.S. military. This deficiency of literature and research illustrates the necessity to explore ROTC officers' perspectives of practices in this context. The purpose of this qualitative study was to explore ROTC officers’ perspectives on DEI practices related to commissioning minority officers in the U.S. military. The conceptual framework was grounded in critical race theory and aversive racism theory. The research question was focused on ROTC officers' perspectives on DEI …


Holding Ground In The Cerulean Tide: Minority Party Legislators' Strategies For Advancing Climate Policies In Landslide States, Sukjae Lee Apr 2025

Holding Ground In The Cerulean Tide: Minority Party Legislators' Strategies For Advancing Climate Policies In Landslide States, Sukjae Lee

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

This dissertation addresses a key puzzle: Why do states sometimes adopt nationally polarized policies, such as climate change legislation, even when doing so does not align with strict partisan interests? The analysis focuses on “landslide states,” where a single party overwhelmingly dominates, and the minority party cannot realistically expect to gain a majority. In these environments, reduced partisan conflict allows minority party legislators to break from traditional partisan paths. As a result, I argue that electoral motivations drive them to signal moderation by advancing liberal policy agendas or incorporating provisions that minimize backlash from their core constituents in landslide states. …


How Do School-Level Dynamics Impact Mainstreaming Practices In American Schools?, Natalie M. Watson Apr 2025

How Do School-Level Dynamics Impact Mainstreaming Practices In American Schools?, Natalie M. Watson

Department of Sociology: Dissertations, Theses, and Student Research

How do school-level dynamics impact the everyday experiences of students with disabilities, compared to their abled peers? Extant research has mostly focused on the experiences of individual students with disabilities, and their teachers. We know far less about how school-level dynamics shape students’ experiences. Historically, American schools formally separated students with and without disabilities, though the specific mode varied over time -- ranging from explicit institutionalization to segregation in special education programs. At least since the passage of the Americans with Disabilities Act in 1990, efforts to educate students with disabilities alongside their abled peers in mainstreamed settings have increased …


Deportation And Immigration Enforcement In The United States: Analysis Of Regional And Country Variations, Exmond Ofori Sarpiah Apr 2025

Deportation And Immigration Enforcement In The United States: Analysis Of Regional And Country Variations, Exmond Ofori Sarpiah

Political Science Theses and Capstones

This study examines the motivations behind President Trump’s mass deportation policies due to the inflow of undocumented migrants from different regions in America. The study employs data visualization techniques, such as scatter plot and bar charts, to analyze regional and country variation trends in migrant removals and undocumented populations across global regions.


Challenges In Higher Education For Latino U.S - Born Children Of Undocumented Immigrants, Lupita Gomez Benitez Apr 2025

Challenges In Higher Education For Latino U.S - Born Children Of Undocumented Immigrants, Lupita Gomez Benitez

Senior Theses

Latino native-born children of undocumented immigrants in the United States occupy a unique position within American society. They are citizens by birth and therefore, entitled to all the rights of a regular citizen. However, society does not treat them as such due to their parents' legal status. This paper analyzes the barriers that these students face during the higher education process, specifically in South Carolina. The study uses a review of existing literature and qualitative interviews to uncover some of these challenges and why these students do not ask for help. The findings suggest that these students do have certain …


"Health Gatekeepers": The Influence Of Women On Health Practices In Rural, Central Appalachia, Reese Lycan Apr 2025

"Health Gatekeepers": The Influence Of Women On Health Practices In Rural, Central Appalachia, Reese Lycan

Senior Theses

Women have historically assumed leadership roles in familial and community health promotion, intervention, and facilitation. While the role of women in family health is globally understood and the historical importance of female leadership has been documented, there remains a gap in knowledge regarding the role of women as “health gatekeepers”. Furthermore, when considering the Appalachian region, there are limited studies regarding women’s place in leadership as far as health is concerned. Therefore, this study employs a hermeneutic phenomenological framework to explore the lived experiences of women in relation to their family and community’s health in rural, Central Appalachia- a region …


Drawing Lines In The Sand: Armed Conflict, Climate Damage And Setbacks To Climate Action, Beatrice L. Hamilton Apr 2025

Drawing Lines In The Sand: Armed Conflict, Climate Damage And Setbacks To Climate Action, Beatrice L. Hamilton

Michigan Journal of Environmental & Administrative Law

Armed conflicts have a significant and detrimental effect on the climate system, with considerable implications for efforts to mitigate and adapt to climate change and the civilian population. Yet the environmental provisions under the law of armed conflict (LOAC), drafted some half a century ago, struggle to adequately address these concerns. This article assesses the capacity of LOAC to address conflict-driven climate damage and its cascading impacts by characterizing these harms as environmental damage and as injury to civilians. The analysis highlights opportunities for broadening LOA C's scope and offers recommendations to enhance its capacity to address climate damage and …


Research On Quantitative Evaluation Of Artificial Intelligence Policy Texts In The Yangtze River Delta Region, Ying Zhou, Danjie Yang, Mei Jiang, Xiaochun Zhao Apr 2025

Research On Quantitative Evaluation Of Artificial Intelligence Policy Texts In The Yangtze River Delta Region, Ying Zhou, Danjie Yang, Mei Jiang, Xiaochun Zhao

Journal of Scientific Information Research

[Purpose/significance]The quantitative evaluation of existing effective artificial intelligence (AI) policies aims to provide reference for government department to formulate scientific and reasonable AI policies and promote the development of AI. [Method/process]Taking 10 AI policies in the Yangtze River Delta region from 2015 to 2024 as the research samples, the text mining method is used to construct the evaluation index system of AI policies in the Yangtze River Delta region, and conduct quantitative evaluation by combining the PMC index model. [Result/conclusion]The study found that from a macro policy text perspective, the average PMC index of the 10 AI policy samples in …


Hubungan Dukungan Sosial Rekan Kerja Dengan Stres Kerja (Studi Pada Pekerja Di Pt X), Aisyah Permatasari Apr 2025

Hubungan Dukungan Sosial Rekan Kerja Dengan Stres Kerja (Studi Pada Pekerja Di Pt X), Aisyah Permatasari

Jurnal Ilmu Kesejahteraan Sosial

Workers are vulnerable to work-related stress due to job demands, time constraints, and limited leisure time, leading to psychological issues such as anxiety related to their work. In the context of social welfare studies, job stress affects overall workers’ well-being and disrupts their social functioning in the workplace. Social support from coworkers is potentially reduce stress in workplace, which is crucial for creating organizational well-being. It also helps workers improve job engagement, cope with fatigue, and manage stress. This study examined the relationship between social support from coworkers and job stress among 90 employees …


Caring Across Borders: Demographic Shifts And Migrant Care In Asean-Korea Dynamics, Saqib Fardan Ahmada, Wahid Nur Kartiko Apr 2025

Caring Across Borders: Demographic Shifts And Migrant Care In Asean-Korea Dynamics, Saqib Fardan Ahmada, Wahid Nur Kartiko

Jurnal Ilmu Kesejahteraan Sosial

This article aims to examine the migration policies and migrant care in the context of relations between ASEAN Member States (AMS) and Korea. As Korea is dealing with an aging population, an increase in female labour force participation, and an ultra low fertility rate, caregiving, especially for the elderly, has become a pivotal issue. Besides, the traditional nuclear family structure, which has historically served as the primary caregiver for the elderly, is also losing its prominence. In such demographic shift, migrant care workers from AMS are filling the demand for caregiving in Korea, leading to a cross-border international migration from …


The Role Of Affordable Housing In Enhancing Tenants' Economic Stability In Connecticut: A Focus On Income, Employment, And Housing Stability, Osaid Zubi Apr 2025

The Role Of Affordable Housing In Enhancing Tenants' Economic Stability In Connecticut: A Focus On Income, Employment, And Housing Stability, Osaid Zubi

Dissertations

This study examined the role of affordable housing in promoting economic stability among low- and moderate-income households in Connecticut. Focusing on income security, employment opportunities, and housing retention, this research highlighted the significance of affordable housing as a means to alleviate financial strain, support job retention, and foster community resilience. Utilizing a phenomenological approach, the study gathered insights from tenants, policymakers, and developers through conducting interviews and a focus group. Connecticut was chosen as the study site due to its high cost of living and affordable housing shortage, exacerbated by its proximity to New York City. Findings underscore the economic …


Beyond The Bickering: Examining Event, Victim, And Offender Characteristics For Sibling Abuse Incidents In Oregon, Isabella M. Starr Apr 2025

Beyond The Bickering: Examining Event, Victim, And Offender Characteristics For Sibling Abuse Incidents In Oregon, Isabella M. Starr

University Honors Theses

Sibling violence (SV) is the most prevalent form of intrafamilial and domestic violence, yet it remains underrecognized and lacks the systematic attention given to other forms of family violence. Often minimized or misclassified as typical sibling rivalry, SV can inflict serious and lasting physical, emotional, and psychological harm on its victims. This study explores the characteristics of sibling violence incidents reported to law enforcement in Oregon between 2016 and 2023, using data from the National Incident-Based Reporting System (NIBRS). Through an analysis of 5,793 single-victim, single-offender incidents, the research examines demographic patterns among victims and offenders, incident dynamics, and typological …


From Flames To Change: An Exploration Of Housing, Fire, And Inequity, Helen Underhill, Charles R. Jennings, Brian Meacham, Danielle Antonellis Apr 2025

From Flames To Change: An Exploration Of Housing, Fire, And Inequity, Helen Underhill, Charles R. Jennings, Brian Meacham, Danielle Antonellis

Publications and Research

Housing and fire safety are deeply connected: inadequate and poorly maintained housing poses heightened fire risk for occupants. An individual or household’s housing situation (including limited or constrained choice) interacts with issues such as affordability, access, location, quality, safety, occupancy levels, tenure type, and resident or immigration status. These dynamics shape vulnerability, and inequity becomes most visible in the event of a fire. The extreme end of this spectrum includes the unhoused, who occupy structures entirely outside of regulatory systems with little or no fire protection.


How Does Adult Foster Care Affect Mental Health Outcomes In California?, Christopher A. Stanley Apr 2025

How Does Adult Foster Care Affect Mental Health Outcomes In California?, Christopher A. Stanley

Master of Public Administration Capstone Papers

Mental health in adult foster care is an important threat to the overall mental health of the citizens of California. Mental health has challenged professionals and recipients of adult foster care. Although mental health and adult foster care have had some connections (i.e., people with mental health issues typically live in adult foster care), the mental health effects of living in an adult foster care have been overlooked. In particular, mental health has been separated from general medical issues and has been overlooked as a necessary part of a person's overall health. This capstone paper will draw upon the literature …


New Policy Tools And Traditional Policy Models: Better Understanding Behavioural, Digital And Collaborative Instruments, Michael Howlett, Sarah Giest, Ishani Mukherjee, Araz Taeihagh Apr 2025

New Policy Tools And Traditional Policy Models: Better Understanding Behavioural, Digital And Collaborative Instruments, Michael Howlett, Sarah Giest, Ishani Mukherjee, Araz Taeihagh

Research Collection School of Social Sciences

The study of policy tools has been undertaken for several decades. This work has isolated and examined many different types of instruments or levers utilized by governments to implement their policies and examined in detail how they are arranged into mixes, packages, or portfolios of tools. However, recent developments in society and technology have highlighted the potential to use new or previously underutilized policy instruments for both traditional tasks and to address new challenges associated with emerging technologies and other contemporary issues. These tools include social media platforms, collaboration, behavioral insights, and data-driven approaches to policy-making and policy design using …


How Seeing Rural America As A Commons Can (Re)Build Mutual Respect Across The Rural-Urban Divide, Lisa R. Pruitt Apr 2025

How Seeing Rural America As A Commons Can (Re)Build Mutual Respect Across The Rural-Urban Divide, Lisa R. Pruitt

West Virginia Law Review

This Essay, written for a symposium that honors and amplifies Ann Eisenberg’s 2024 book, Reviving Rural America: Toward Policies for Resilience, contemplates benefits that could flow from taking seriously Eisenberg’s conceptualization of rural America as a commons. In particular, I argue that the mutual respect and collaboration necessary for a successful commons could help heal the rural-urban rift, which has widened dramatically in the last few decades. Recent studies suggest that rural residents have what scholars call a rural consciousnesses, which means that living in a rural place is a key aspect of their identity. One feature of this identity …


Policymakers’ Perceptions About Providing Affordable Housing In Rural Georgia, Robert Joseph Wiley Apr 2025

Policymakers’ Perceptions About Providing Affordable Housing In Rural Georgia, Robert Joseph Wiley

Walden Dissertations and Doctoral Studies

The literature showed that low-income households face a persistent deficit of affordable housing, forcing these families to live in dilapidated housing or to live beyond their means to pay for adequate housing, and that this problem transcends rural and urban counties. Further, researchers indicated that solving this problem provided a stable workforce and a better quality of life for all income groups. A gap in the literature showed the need for more research on nonmetropolitan communities addressing housing and neighborhood revitalization; therefore, through this qualitative multiple-case study local policymakers' perceptions of the affordable housing problem in rural Georgia were explored. …


Preferences And Willingness For Starting Daily, On-Demand, And Long-Acting Injectable Hiv Pre-Exposure Prophylaxis Among Transfeminine Persons In The Us, 2022-2023, Duygu Islek, Travis Sanchez, Stefan Baral, Carolyn Brown, Joanna A. Caldwell, Jennifer L. Glick, Danielle Friedman Nestadt, Jeb Jones, Iaah L. Lucas, Supriya Sarkar, Annemiek De Ruiter, Patrick S. Sullivan, Mariah Valentine-Graves, Savannah Winter, Vani Vannappagari Apr 2025

Preferences And Willingness For Starting Daily, On-Demand, And Long-Acting Injectable Hiv Pre-Exposure Prophylaxis Among Transfeminine Persons In The Us, 2022-2023, Duygu Islek, Travis Sanchez, Stefan Baral, Carolyn Brown, Joanna A. Caldwell, Jennifer L. Glick, Danielle Friedman Nestadt, Jeb Jones, Iaah L. Lucas, Supriya Sarkar, Annemiek De Ruiter, Patrick S. Sullivan, Mariah Valentine-Graves, Savannah Winter, Vani Vannappagari

School of Public Health Faculty Publications

Background There remains limited information concerning US transfeminine persons preferences across varying PrEP options. We examined PrEP option willingness, preferences, and associated factors among a US nationwide sample of transfeminine persons. Methods Sexually active transfeminine persons age 15 + were recruited online between June 2022-October 2023 through social media advertisements. Transfeminine persons not diagnosed with HIV were asked about willingness to initiate, and ranked preference, of three PrEP options- daily oral (DO), on-demand, and long-acting injectable (LA-PrEP). Log-binomial models were used to examine PrEP modality willingness and associated sociodemographic and behavioral characteristics. Results Among 2657 transfeminine persons not currently using …


The Employment Situation Of Veterans: April 2025, Institute For Veterans And Military Families At Syracuse University Apr 2025

The Employment Situation Of Veterans: April 2025, Institute For Veterans And Military Families At Syracuse University

Institute for Veterans and Military Families

In April 2025, the U.S. added 177,000 jobs, with the national unemployment rate holding at 4.2%. Veteran unemployment declined to 3.5% from 3.8% in March, while Post-9/11 veterans saw a drop to 2.9%. Male veteran unemployment fell to 3.1%, but female veteran unemployment rose to 5.9%. Black and Hispanic veterans experienced significant improvements, with rates falling to 4.8% and 2.9%, respectively—both lower than their nonveteran peers. Younger veterans (25–34) and those aged 45–54 saw notable declines, while veterans aged 55–64 experienced a slight increase. Despite gains, disparities remain, especially for female and older veterans.


Ethical Ai Use And Classroom Integration Training Modules, Daniel Boudon Apr 2025

Ethical Ai Use And Classroom Integration Training Modules, Daniel Boudon

Open Educational Resources

This project focuses on developing comprehensive training modules to equip students and faculty with the knowledge and skills necessary to ethically and effectively use AI tools in academic settings. The training consists of interconnected modules that cover a wide range of topics, including the ethical use of AI, evaluating AI-generated content, integrating AI tools into curriculum design, and creating AI-enhanced classroom activities. Additional modules emphasize fostering digital literacy, staying updated with AI advancements, and collaborating on best practices for AI in education.

Designed for flexibility, the modules cater to diverse academic disciplines, making them suitable for undergraduate and graduate courses, …


Latent Active Transportation Methodology, Maria Chierichetti, Fatemeh Davoudi Kakhki Apr 2025

Latent Active Transportation Methodology, Maria Chierichetti, Fatemeh Davoudi Kakhki

Mineta Transportation Institute

Understanding and estimating latent demand for active transportation, such as walking and cycling, is essential for designing infrastructure and policies that promote sustainable mobility. Unlike traditional demand models that focus on observed trips, latent demand estimation seeks to quantify the unrealized potential for active travel due to barriers such as inadequate infrastructure, safety concerns, or lack of connectivity. This study develops a comprehensive latent demand model tailored for California, integrating geospatial analysis and multimodal accessibility assessments. The methodology employs a GIS-based corridor analysis approach, utilizing spatial accessibility metrics and distance decay functions to evaluate potential demand. It incorporates employment and …


2025 April, Morehead State University. Office Of Communications & Marketing. Apr 2025

2025 April, Morehead State University. Office Of Communications & Marketing.

Morehead State Press Release Archive, 1961 to the Present

Press releases for April of 2025.


Navigating Food Insecurity: Families’ Coping Strategies, Challenges, And Insights For Educators, Ndũcũ Ngũgĩ Apr 2025

Navigating Food Insecurity: Families’ Coping Strategies, Challenges, And Insights For Educators, Ndũcũ Ngũgĩ

Theses & Dissertations

Food is essential for life. It fuels growth, well-being, and stability. Yet, food insecurity -uncertain or inadequate access to sufficient food- remains a jarring reality for millions. In the U.S. alone, 47 million people, including 14 million children, experience food insecurity despite government efforts. Addressing this crisis is essential for public health, socioeconomic progress, and societal welfare. This narrative study’s main objective was to understand the lived experiences of food-insecure families by examining how they navigate the challenges they face, their inventive coping mechanisms, and the insights they can provide for educators. While research has shown the adverse effects of …


A Novel Method For Semi-Quantitative Detection Of Hpv16 And Hpv18 Mrna With A Low-Cost, Open-Source Fluorimeter, Kathryn A Kundrod, Mary E Natoli, Chelsey A Smith, Jackson B Coole, Megan M Chang, Emilie Newsham Novak, Elizabeth Chiao, Elizabeth A Stier, Jane R Montealegre, Michael E Scheurer, Philip E Castle, Kathleen M Schmeler, Rebecca R Richards-Kortum Apr 2025

A Novel Method For Semi-Quantitative Detection Of Hpv16 And Hpv18 Mrna With A Low-Cost, Open-Source Fluorimeter, Kathryn A Kundrod, Mary E Natoli, Chelsey A Smith, Jackson B Coole, Megan M Chang, Emilie Newsham Novak, Elizabeth Chiao, Elizabeth A Stier, Jane R Montealegre, Michael E Scheurer, Philip E Castle, Kathleen M Schmeler, Rebecca R Richards-Kortum

Center for Medical Ethics and Health Policy Staff Publications

Despite global calls to eliminate cervical cancer, rates of cervical cancer incidence and mortality remain high in resource-limited settings, where it is challenging to implement and sustain screening, diagnosis, and treatment programs. The presence of high-risk HPV mRNA in cervical cells is a sensitive and specific biomarker of cervical precancer. Yet, current testing methods are too costly and complex for use in resource-limited settings. Here, we present a novel method for semi-quantitative detection of HPV16 and HPV18 mRNA with minimal infrastructure requirements. The assay relies on isothermal reverse transcription recombinase polymerase amplification (RT-RPA) with real-time fluorescence readout, demonstrated on rugged, …


Crispr/Cas9 Gene Therapy Increases The Risk Of Tumorigenesis In The Mouse Model Of Hereditary Tyrosinemia Type I, Tong Chen, Mercedes Barzi, Nika Furey, Hyunjae R Kim, Francis P Pankowicz, Xavier Legras, Sara H Elsea, Ayrea E Hurley, Diane Yang, David A Wheeler, Malgorzata Borowiak, Beatrice Bissig-Choisat, Pavel Sumazin, Karl-Dimiter Bissig Apr 2025

Crispr/Cas9 Gene Therapy Increases The Risk Of Tumorigenesis In The Mouse Model Of Hereditary Tyrosinemia Type I, Tong Chen, Mercedes Barzi, Nika Furey, Hyunjae R Kim, Francis P Pankowicz, Xavier Legras, Sara H Elsea, Ayrea E Hurley, Diane Yang, David A Wheeler, Malgorzata Borowiak, Beatrice Bissig-Choisat, Pavel Sumazin, Karl-Dimiter Bissig

Center for Medical Ethics and Health Policy Staff Publications

Background & aims: The therapeutic potential of CRISPR gene editing has been demonstrated in various animal models; however, little is known about its long-term consequences. This study seeks to bridge this gap by investigating the lasting consequences of CRISPR gene therapy in an animal model of hereditary tyrosinemia type I (HT-I). We compared the standard of care-nitisinone, a small molecule inhibitor of hydroxyphenylpyruvate dioxygenase (HPD)-with the deletion of the Hpd gene by CRISPR gene therapy. Both treatments block flux through tyrosine catabolism and thereby prevent the accumulation of toxic catabolites in HT-I.

Methods: We assessed the efficacy and safety of …