Digital Commons Network^™

The Impact Of Clinical Genome Sequencing In A Global Population With Suspected Rare Genetic Disease, Erin Thorpe, Taylor Williams, Chad Shaw, Evgenii Chekalin, Julia Ortega, Keisha Robinson, Jason Button, Marilyn C Jones, Miguel Del Campo, Donald Basel, Julie Mccarrier, Laura Davis Keppen, Erin Royer, Romina Foster-Bonds, Milagros M Duenas-Roque, Nora Urraca, Kerri Bosfield, Chester W Brown, Holly Lydigsen, Henry J Mroczkowski, Jewell Ward, Fabio Sirchia, Elisa Giorgio, Keith Vaux, Hildegard Peña Salguero, Aimé Lumaka, Gerrye Mubungu, Prince Makay, Mamy Ngole, Prosper Tshilobo Lukusa, Adeline Vanderver, Kayla Muirhead, Omar Sherbini, Melissa D Lah, Katelynn Anderson, Jeny Bazalar-Montoya, Richard S Rodriguez, Mario Cornejo-Olivas, Karina Milla-Neyra, Marwan Shinawi, Pilar Magoulas, Duncan Henry, Kate Gibson, Samuel Wiafe, Parul Jayakar, Daria Salyakina, Diane Masser-Frye, Arturo Serize, Jorge E Perez, Alan Taylor, Shruti Shenbagam, Ahmad Abou Tayoun, Alka Malhotra, Maren Bennett, Vani Rajan, James Avecilla, Andrew Warren, Max Arseneault, Tasha Kalista, Ali Crawford, Subramanian S Ajay, Denise L Perry, John Belmont, Ryan J Taft

Center for Medical Ethics and Health Policy Staff Publications

There is mounting evidence of the value of clinical genome sequencing (cGS) in individuals with suspected rare genetic disease (RGD), but cGS performance and impact on clinical care in a diverse population drawn from both high-income countries (HICs) and low- and middle-income countries (LMICs) has not been investigated. The iHope program, a philanthropic cGS initiative, established a network of 24 clinical sites in eight countries through which it provided cGS to individuals with signs or symptoms of an RGD and constrained access to molecular testing. A total of 1,004 individuals (median age, 6.5 years; 53.5% male) with diverse ancestral backgrounds …

The Nexus Between Revenue Decentralization Reforms And Economic Growth, Frankline Muthomi, Titus M. Ndunda

Public Administration Faculty Publications and Presentations

Revenue decentralization represents a framework that facilitates enhanced fiscal autonomy for subnational governments, thereby enabling the tailoring of services to meet local needs and potentially fostering economic growth. In Kenya, the ratification of the 2010 constitutional formalized novel revenue frameworks aimed at supporting the operations, management, and sustainability of devolved county governments. However, there remains a paucity of empirical analysis examining the relationship between the revenue decentralization reforms and county-level economic growth. We begin by identifying the main sources of county revenues within the decentralization frameworks, then investigate the dynamic interrelation with county economic growth. Through panel vector autoregression estimation …

Transportation, Healthcare Seeking, And Outcomes, Xiao Lin Ong

Dissertations and Theses Collection (Open Access)

Advancements in engineering and transportation technology have integrated commuting into modern living. Most studies on transportation infrastructure, such as roads and railways, focus on economic outcomes. This paper examines an overlooked outcome of transportation connectivity: access to medical care. We study the role transportation networks play in determining patients’ treatment location choices. Specifically, we aim to study 1) why patients travel to begin with, 2) how do patients choose where to go for treatment, and 3) how travel times can affect patients’ travel decisions. To do so, we develop a dynamic discrete choice, spatial model and provide empirical estimates. We …

Decentralized Clinical Trials For Medications To Reduce The Risk Of Dementia: Consensus Report And Guidance, Leanne Howard, Carla Abdelnour, Erin Abner, Ricardo F. Allegri, Hiroko H. Dodge, Serge Gauthier, Camilla M. Hoyos, Gregory Jicha, Patrick G. Kehoe, Catherine J. Mummery, Adesola Ogunniyi, Nikolaos Scarmeas, Xiaoying Chen, Jodie R. Titiner, Christopher R. Weber, Ruth Peters

Neurology Faculty Publications

INTRODUCTION: Recent growth in the functionality and use of technology has prompted an increased interest in the potential for remote or decentralized clinical trials in dementia. There are many potential benefits associated with decentralized medication trials, but we currently lack specific recommendations for their delivery in the dementia field.

METHODS: A modified Delphi method engaged an expert panel to develop recommendations for the conduct of decentralized medication trials in dementia prevention. A working group of researchers and clinicians with expertise in dementia trials further refined the recommendations.

RESULTS: Overall, the recommendations support the delivery of decentralized trials in dementia prevention …

The Colorado Wolf Reintroduction Portrayal In News Media, Megan K. Mcarthur, Monica V. Ogra

Student Publications

The Colorado gray wolf (Canis lupus) reintroduction began in December 2023 in the hope of restoring this once native population to the area, and it has received mixed responses from the media. By answering the research question of 'How has the wolf reintroduction in Colorado been framed in news media?', this research poster looks at the portrayal of the reintroduction in news articles from six months before and after the first wolves were released. Media is an influential factor in people's opinions and it is important to be aware of the information being shared and any bias within them.

The Need For Localized, Socio-Economic Policy Measures For Controlling A Pandemic: An Empirical Study Of Covid-19 In India, Ashish Gupta, Prashant Das, Dongshin Kim

All Faculty Open Access Publications

The COVID-19 pandemic, a black swan event, created an unprecedented global health hazard and disrupted global economic activities. During the first wave of the COVID-19 pandemic, various governments announced lockdowns. India went under lockdown from 25 March 2020 for 21 days. These lockdowns disrupted the social fabric and economic activities. We examined the demographic and socio-economic determinants of COVID-19 infections and deaths across over 400 districts in India. Using statistical methods, we observed that the infection patterns demonstrate localized characteristics across districts. Areas with a larger male population and higher economic activity witnessed higher infection rates. Districts with more agricultural …

Readability And Suitability Of Local Disaster Preparedness Materials In Predominantly Hispanic Border Communities: A Case Study Of Cameron County, Texas, Katarzyna Sepielak, Dawid K. Wladyka

Sociology Faculty Publications

Community awareness is a key component of disaster resilience and numerous agencies developed a plethora of preparedness materials. Previous studies evaluated national-level resources and social media content indicating that these efforts are not effectively reaching vulnerable populations, as the information is provided at or above the secondary education level. However, the local-specific content has been mostly overlooked in the analyses, subsequently neglecting the needs of areas with specific demographics and hazards, like predominantly Hispanic border communities. Thus, this study turns to local preparedness and mitigation materials, rather than general internet searches or national level documents. We analyze information provided on …

Bridging The Nature-Cultural Heritage Gap: Evaluating Sustainable Entanglements Through Cemeteries In Urban Asia, David Ocon, Wei Ping Young

Research Collection School of Social Sciences

The expanding footprint of urban Asian settlements and increasing living standards have put pressure on cemetery sites. Public health narratives and the sanctity associated with death matters in Asian urban landscapes have fed into the rhetoric of cemeteries as undesirable heritage spaces. Often lacking protection, many cemeteries have been exhumed, cleared, and relocated to allow room for new developments and infrastructure, risking the survival of this quiet element of the urban cultural patrimony. Within an Asian context, synergies between nature and cultural heritage preservation are not prevalent in major cities like Singapore, Hong Kong, Tokyo, Manila, Kuala Lumpur, and Bangkok. …

Insourcing The Smart City: Assembling An Ideo-Technical Ecosystem Of Talent, Skills, And Civic-Mindedness In Singapore, Orlando Woods, Tim Bunnell, Lily Kong

Research Collection College of Integrative Studies

This article examines an alternative model of smart city formation, one based on the principle of insourcing technical competencies and capabilities to those responsible for city governance. This model counters the logic of technological outsourcing upon which many assumptions and critiques of the smart city rest, and thus reveals ways in which a more generative discourse can be forged. Drawing on a series of in-depth interviews with senior stakeholders from public and private sector organizations, we develop a case study of Singapore’s Smart Nation initiative. Through coordinated efforts to reorganize the public sector’s technological functions, develop nation-wide skills upgrading programs, …

Impact Of Rainfall On Air Temperature, Humidity And Thermal Comfort In Tropical Urban Parks, Juan A. Acero, Philip Carl Kestel, Hieu T. Dang, Leslie K. Norford

Research Collection College of Integrative Studies

Urban areas in hot and humid tropical regions are frequently exposed to uncomfortable thermal levels. A well-developed urban heat mitigation strategy is increasing vegetation infrastructure, even though the impact differs based on regional climate. In this study we have evaluated the impact of rainfall on air temperature, humidity and thermal comfort inside a large urban park in Singapore, based on measurement campaigns. A comparison between the park and an urban site is presented. Results show that rainfall significantly reduces air temperature and improves thermal comfort levels, not only right after the rain event but also in the after-event dry period. …

A Comparative Review Of Soil Carbon Sequestration Methods In Brazil’S Agriculture, Skylar Cheng

Discussions

Brazil is under unique pressure to adopt sustainable agricultural practices due to its intricate biodiversity and globally dominant agricultural sector. Increasing soil degradation, agricultural land expansion, and rising levels of atmospheric carbon are nationwide concerns that require multifaceted solutions. Integrated agricultural systems, which rehabilitate soils through crop, forage, and livestock rotation as well as biochar—a carbon-rich soil amendment—can address such concerns. These sustainable farming practices improve carbon sequestration and soil fertility; however, uptake remains minimal due to environmental, economic, and policy barriers. Accordingly, this paper proposes a comprehensive model of integrated systems and biochar, in which the benefits of one …

Natural Hazards Triggering Technological Disasters: Source Identification, Vulnerability, And Evaluation Of Emergency Preparedness In A Southern California City, Lisa Peumsang

Walden Dissertations and Doctoral Studies

Natural hazards triggering technological disasters (natech) events exist around the world and affect people, infrastructure, the economy, and environment but are not often considered for local hazard mitigation and emergency preparedness plans. The purpose of this qualitative case study was to identify (a) the natech event vulnerability of the target city, which is in the western United States, and potential sources for these events and (b) the extent to which the city’s hazard mitigation and emergency operations plans addressed natech events. The vulnerability assessment was performed through the lens of network risk theory and involved secondary data analysis of publicly …

Natural Hazards Triggering Technological Disasters: Source Identification, Vulnerability, And Evaluation Of Emergency Preparedness In A Southern California City, Lisa Peumsang

Walden Dissertations and Doctoral Studies

Natural hazards triggering technological disasters (natech) events exist around the world and affect people, infrastructure, the economy, and environment but are not often considered for local hazard mitigation and emergency preparedness plans. The purpose of this qualitative case study was to identify (a) the natech event vulnerability of the target city, which is in the western United States, and potential sources for these events and (b) the extent to which the city’s hazard mitigation and emergency operations plans addressed natech events. The vulnerability assessment was performed through the lens of network risk theory and involved secondary data analysis of publicly …

From Made In China” To “Created In China”: Intellectual Property Rights In The People’S Republic Of China, Gerald J. Krieger

Joint Force Quarterly

No abstract provided.

Position, Navigation, And Timing Weaponization In The Maritime Domain: Orientation In The Era Of Great Systems Conflict, Diane M. Zorri, Gary C. Kessler

Joint Force Quarterly

The jamming and spoofing of Global Positioning System (GPS) and the Automatic Identification System (AIS) information has escalated in the last half-dozen years from simple demonstrations of capability to truly dangerous situations where misperceptions could ignite a major conflict. Because of the grave danger that GPS and AIS weaponization entails, it is essential that policymakers and maritime operators understand not only the risks and implications of these threats, but also the mitigation techniques and countermeasures that add resilience to the warfighter.

Defending An Achilles’ Heel: Evolving Warfare In The Philippines, 1941–1945, Robert S. Burrell

Joint Force Quarterly

The Pacific War during World War II provided valuable lessons in military strategy and the importance of unconventional warfare. Japan’s aggressive expansion in the 1930s and 1940s left to a major conflict with the United States over control of the Philippine Islands. Japan’s advancements in naval technology, including the largest battleships and superior night combat tactics, allowed them to invade the Philippines in December 1941. Filipino resistance against Japanese occupation grew, with various local groups using guerilla warfare tactics to fight back. These resistance movements played a crucial role in opposing Japanese forces. Intelligence operations were also vital. U.S. submarines …

The Other Arctic: Competition, Cooperation, Or Coexistence?, John B. Kelley, Christopher J. Sarton, Scott A. Curtice, Charles C. York Iii

Joint Force Quarterly

In Antarctica, the United States must mitigate risks stemming from competitive influences working to alter the current paradigms, but it also should seize the opportunities that Antarctica’s unique status affords. As climate change continues to open new opportunities in polar regions, international concern has grown over the potential for the future irresponsible use of the area by actors more concerned with military and economic advantage than conservation efforts. Apprehension over the People’s Republic of China (PRC)’s activities raises more significant concerns that Antarctica may become a region of military competition instead of global cooperation. This apprehension is well-founded but not …

Technological Challenges And Development Directions Of Ecological Security Barrier Construction In Yun-Gui-Chuan-Yu Region, Peng Cui, Yongping Yang, Genxu Wang, Bo Zhu, Xuyang Lu, Geng Sun, Xiaoyong Bai, Sirui Zhang, Yonggang Ge, Jiao Wang

Bulletin of Chinese Academy of Sciences (Chinese Version)

The Yun-Gui-Chuan-Yu Ecological Security Barrier is situated in Southwest China, encompassing the provinces of Sichuan, Chongqing, Guizhou, and Yunnan. It serves as a vital water source conservation area and a core zone for biodiversity protection for the Yangtze, Yellow, and Pearl River basins, playing a crucial role in China’s national ecological security. Since the 18th National Congress of Communist Party of China, under the guidance of Xi Jinping’s Thought on Ecological Civilization, the region has made significant strides in water resource protection, soil erosion and mountain disaster control, biodiversity conservation, and ecosystem restoration, resulting in noticeable improvements in environmental quality …

Scientific And Technological Measures To Support Sustainability Of Water Resources In Western China, Jun Xia, Xi Chen, Qiuhong Tang, Hongwei Lu, Shaofeng Jia, Genxu Wang, Jingjie Yu, Jinzhu Ma, Xingcai Liu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Under the combined impacts of climate change and human activities, the ecological barrier regions of western China exhibit significant reductions in solid water storage, increases in liquid water, declining water resource stability and non-steady-state characteristics in hydrological systems. Water allocation risks have increased, making it exponentially more difficult to ensure water security. Transboundary water resource development can lead to spillover risks, requiring urgent research on sustainable water resource use and adaptation strategies. The water cycle in western China is driven by both natural and anthropogenic factors, yet fundamental research on water cycle dynamics and resource management under changing environments remains …

Exploration On Path Of Ecological Protection And Economic Development In Qilian Mountain National Park Region, Xinmiao Tian, Qi Feng

Bulletin of Chinese Academy of Sciences (Chinese Version)

National parks are a kind of special protected areas established under the leadership of the government with the core objective of protecting the integrity of natural ecosystems and biodiversity, which emphasizes the balance between human activities and nature protection in order to achieve sustainable coexistence of human being and nature. The construction of a system of nature reserves with national parks as the core is a major breakthrough progress in the institutional framework of China’s ecological civilization, and a key area for promoting the construction of Beautiful China and realizing the modernization of harmonious coexistence of human being and nature. …

Current Status, Challenges, And Policy Recommendations For Industrial Development In The Yellow River Basin, Chaokai Xue, Kaihua Chen, Quanjing Wang, Yujie Zhang, Xiaohui Qu, Mengfei Zhang, Haitao Ma

Bulletin of Chinese Academy of Sciences (Chinese Version)

The foundation for ecological protection and high-quality development in the Yellow River Basin lies in the rational development of industry. This study systematically analyzes the current state of industrial development in the Yellow River Basin, examining traditional industries, strategic emerging industries, and future industries. Based on this analysis, it identifies key issues and development directions. The study reveals that the industrial structure in the Yellow River Basin is unreasonable; traditional industries have short chains and high energy consumption; the cultivation of strategic emerging industries is inadequate and poorly aligned; and comprehensive planning for future industries is inadequate. Therefore, it is …

Research On Current Situation And Optimization Strategy Of Cross-Regional Scientific And Technological Innovation Cooperation In The Yellow River Basin, Gupeng Zhang, Wenbo Guo, Huiling Liang, Jingjing Zhang, Dongzhu Lu, Baorong Hou, Yan Liang, Weiyu Duan

Bulletin of Chinese Academy of Sciences (Chinese Version)

Realizing effective cross-regional innovation cooperation not only helps to enhance the overall scientific and technological innovation capabilities of the Yellow River Basin, but also is crucial for promoting the western development strategy and achieving industrial upgrading and leapfrogging in the western region. The innovation collaborative network composed of various enterprises, universities, and research institutes across different regions in the Yellow River Basin helps to break down information silos and help provinces and cities fully achieve information sharing in open scientific and technological innovation cooperation platforms. The cross-regional innovation collaborative network that have been constructed in the Yellow River Basin consists …

Book Review: The Decline And Fall Of Republican Afghanistan, Whitney Grespin

Parameters Bookshelf – Online Book Reviews

Authors: Ahmad Shuja Jamal and William Maley

Reviewed by Dr. Whitney Grespin, visiting research fellow, King's College London, UK Defence Academy; non-resident fellow, Joint Special Operations University; and Africa Regional Program Lead, DSCA/DSCU Institute for Security Governance

Foreign-policy expert Dr. Whitney Grespin reviews a “deservedly cutting reflection on mistakes made and lessons not learned during the Afghanistan War.” She notes the book’s “valuable perspective,” as one of the authors was in Kabul when it fell. Distilling the book’s contents into a detailed, useful overview, Grespin provides a helpful roadmap for readers interested in these topics and concludes the book is …

Muscat, Madrid, Ulster, And The Holy Land: The Medrc Model Of Environmental Peacebuilding In A Revived Middle East Peace Process, Ciarán Ó. Cuinn

New England Journal of Public Policy

Mandated to assist the Middle East peace process through environmental diplomacy, MEDRC, the last surviving institution of that process, has survived through an institutional and operational approach to conflict resolution separate from the rest of the process. Understanding its transferable approach is important in fields of environmental diplomacy and conflict resolution not only in the context of combating transboundary climate and environmental threats but of using these threats as entry points into a peace process. As the international community grapples with the need for a credible solution to the intractable conflict in Israel and Palestine, the MEDRC approach has implications …

Spatial Analysis Of Transgender And Gender Diverse Students’ Mental Health And School Board Policies In Colorado And Montana, Elizabeth Heiny

Geography and the Environment: Graduate Student Capstones

As the number of policies impacting transgender and gender diverse (TGD) people increase among school boards, understanding the impacts these policies have on mental health is important. These policies can be positive or negative. Using geographic information systems (GIS) to analyze where better mental health and TGD impacting policies are correlated can offer clear results on where students mental health is affected by these policies in Colorado and Montana. This study found that TGD impacting policies did not explain the majority of variation in mental health index score. Positive or negative correlations between the mental health index and policy positivity …

Peace-Building And Stability After Civil Wars: The Cases Of Angola And The Democratic Republic Of The Congo, Ali Elsharkawy

Theses and Dissertations

Why do some rebel groups successfully establish stable and sustainable states after civil wars, while others fail? Angola and the Democratic Republic of the Congo are two African countries that experienced long and bloody civil wars. Despite the commonalities, the two cases strongly diverged in the political outcomes after civil war. Angola successfully made the transition to stability and prosperity, while the DRC slipped back into violence. This thesis compares and contrasts between the two peace- building processes in both countries. The results illustrate that two main variables made the difference between the two cases, the geography of the capital …

A Critical Policy Analysis Of Universal Preschool In Colorado: Its Roots, Intentions, And Development, Jamita Horton

Electronic Theses and Dissertations

High-quality preschool experiences are essential for preparing four-year-old children for a successful transition to kindergarten, benefiting them academically, emotionally, socially, and physically. However, access to such preschools remains limited, particularly for children from marginalized communities. This qualitative critical policy analysis examines transitioning from the targeted Colorado Preschool Program (CPP) to a universal preschool approach through the 2022 Colorado House Bill 1295: Department of Early Childhood and Universal Preschool Program. Drawing on Young and Diem's (2017) framework for critical policy analysis, this study explores the roots, development, and potential implications of the universal preschool policy.

This study analyzes documents and audio …

Wasted Space: Using Parking Lots & Vacant Land To Improve Neighborhood Completeness, Ryan Martyn

Hatfield Graduate Journal of Public Affairs

This study conducts a spatial analysis of Portland, Oregon, focusing on leveraging underutilized areas like parking lots and vacant land—termed "wasted space"—to improve the city's completeness. Central to this investigation is the concept of a "complete neighborhood," characterized by access to daily necessities within convenient active transportation trip. This comprehensive idea encompasses walkability, equitable access to services, and sustainability.

This paper aims to redefine the concept of a complete neighborhood with precision and delve into its implications. The research looks at five regional, town, and neighborhood centers as defined by the city of Portland. These centers act as pivotal hubs …

Policy Diffusion Among Domestic Political Parties In Multiparty Systems: An Analysis Of Election Manifestos Of Indian Political Parties, Payel Nasrin

Hatfield Graduate Journal of Public Affairs

Do political parties adopt each others’ ideas? This research argues that parties are more likely to employ party platforms from electorally successful domestic parties in a multiparty system while seeking public office. Focusing on religious issues as the issue of measurement, I studied 23 election manifestos of 7 political parties that opposed India’s two biggest and historical parties, the Bharatiya Janata Party (BJP) and the Indian National Congress (INC), in the state and national elections during the period of 2004 to 2022. I have analyzed the changes made in the manifesto of these parties to gain insight into the influence …

“Salmon Don’T Have Time For Us To Fix The Climate”: The Politics Of Climate Change And Dam Breaching On The Lower Snake River, Zanna Stutz

Geography Undergraduate Senior Theses

This thesis examines the politics of climate change and dam breach on the Lower Snake River. Located in Southeastern Washington within the Columbia River Basin, the four Lower Snake River dams (LSRD) have long been a source of political and legal controversy. While dam proponents advocate for services that they provide, which includes hydropower, navigation, and irrigation, others contend that their environmental impacts, particularly on salmon and steelhead, make them legally, environmentally, and morally irresponsible. Within this space, I specifically investigate how climate change has influenced the environmental politics and conflicts that surrounds dam breaching, further exploring how competing values …