Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Public Affairs, Public Policy and Public Administration

Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 1741 - 1770 of 17298

Full-Text Articles in Entire DC Network

The State Of The Unions 2024: A Profile Of Organized Labor In New York City, New York State, And The United States, Ruth Milkman, Joseph Van Der Naald Aug 2024

The State Of The Unions 2024: A Profile Of Organized Labor In New York City, New York State, And The United States, Ruth Milkman, Joseph Van Der Naald

Publications and Research

This report released by the CUNY School of Labor and Urban Studies, State of the Unions 2024: A Profile of Organized Labor in New York City, New York State, and the United States, is a part of an annual publication series, documents recent trends in unionization patterns. The CUNY School of Labor and Urban Studies’ latest annual report on unionization patterns shows that private-sector union organizing efforts continued to increase across the country over the last year. The report documents that growth in union election petitions since 2020 has reversed a decade of decline, reaching a level not seen since …


Book Reviews, Usawc Press Aug 2024

Book Reviews, Usawc Press

The US Army War College Quarterly: Parameters

No abstract provided.


A Qualitative Study On Transnational Caregiving For Older Parents In China, Silai Dong Aug 2024

A Qualitative Study On Transnational Caregiving For Older Parents In China, Silai Dong

Lingnan Theses (MPhil & PhD)

The increasing number of international migrations in China poses challenges for the care of older parents who are left behind, considering China’s emphasis on family support. This study aims to investigate transnational care arrangements for older parents whose children are overseas. It mainly addresses three research questions:1) What are the contents of filial piety in the context of international migration? 2) How do Chinese transnational family members negotiate and distribute elder care responsibilities? 3) To what extent can the transnational caregiving model explain elder care in Chinese transnational families?

The transnational caregiving model proposed by Baldassar, Baldock, and Wilding, in …


‘Brain Drain’: Net Gains And Losses Of College- Educated Residents In The Mountain West, 2023, Dre Boyd-Weatherly, Annie Vong, Caitlin J. Saladino, William E. Brown Jr. Aug 2024

‘Brain Drain’: Net Gains And Losses Of College- Educated Residents In The Mountain West, 2023, Dre Boyd-Weatherly, Annie Vong, Caitlin J. Saladino, William E. Brown Jr.

Higher Education

This fact sheet examines the number of college-educated individuals who moved to Mountain West states (Arizona, Colorado, Nevada, New Mexico, and Utah) and to selected metropolitan statistical areas (MSAs) in the Mountain West in 2023. The “2024 Study: ‘Brain Drain’? The States With the Largest Net Gains and Losses of College-Educated Americans” report contains data from the Annual Social and Economic Supplement (ASEC) of the Current Population Survey conducted by the United States Census Bureau. The study includes data on where college-educated residents move and which areas experienced ‘brain drain,’ where college-educated residents move to other places.


Us-Mexico Relations: Addressing Challenges At The Border, The Brookings Institution Aug 2024

Us-Mexico Relations: Addressing Challenges At The Border, The Brookings Institution

Brookings Mountain West Special Events

Mexico’s president-elect Claudia Sheinbaum will begin her six-year term in October as the U.S. presidential campaign enters its final stretch. How the next U.S. administration and Congress manage relations with new leadership in Mexico will affect border security, immigration policies, trade and energy relations, and counter-narcotics and anti-crime cooperation. What tools can policymakers in both countries use to advance positive outcomes? What are the opportunities and challenges that lie ahead for the United States and Mexico?

The Brookings Foreign Policy program in partnership with Brookings Mountain West at UNLV hosted a discussion on the state of U.S.-Mexico relations. Panelists analyzed …


Gender Gaps In Unlv And Unr Graduate College Enrollment And Graduation, 2013-2022, Miguel Soriano Ralston, Annie Vong, Caitlin J. Saladino, William E. Brown Jr. Aug 2024

Gender Gaps In Unlv And Unr Graduate College Enrollment And Graduation, 2013-2022, Miguel Soriano Ralston, Annie Vong, Caitlin J. Saladino, William E. Brown Jr.

Higher Education

This fact sheet explores gender gaps in enrollment numbers and graduation rates of students pursuing graduate degrees at the University of Nevada, Las Vegas (UNLV) and the University of Nevada, Reno (UNR). The original data was provided to The Lincy Institute and Brookings Mountain West by the UNLV Graduate College and gathered from the UNR Reporting Portal.


Process-Oriented Explanation Of Institutional Changes : Comparative Cases Of National Health And Pension System Reforms In Indonesia, Tauchid Komara Yuda Aug 2024

Process-Oriented Explanation Of Institutional Changes : Comparative Cases Of National Health And Pension System Reforms In Indonesia, Tauchid Komara Yuda

Lingnan Theses (MPhil & PhD)

This dissertation compares the causal mechanisms by which healthcare and pension systems in Indonesia have been developed. Despite their shared historical trajectories, the health reform emerged successful, while the pension reform faltered. The study employs process tracing to dissect the specific processes through which the Indonesian production regime and political bargains in 1998–2015 influenced these reforms. It commences with the generation of ideal-type mechanisms based on relevant studies, which are then tested in different cases. The researcher then connects the theoretically expected causality with fieldwork data, reconstructing a revised graph of causal mechanisms that links the crisis and reforms/inertia for …


Outbidding With Ontology: Routine, Rebel Justice, And The Competition For Legitimacy, Patrick A. Schmidt Aug 2024

Outbidding With Ontology: Routine, Rebel Justice, And The Competition For Legitimacy, Patrick A. Schmidt

Electronic Theses and Dissertations

Civil wars upset the everyday routines and relationships of ordinary people. Though recent research into civil wars has significantly increased the degree of study into non-conflict activities of rebel groups, particularly in rebel governance, rebel groups have not yet been seen as ontological security providers, capable of developing and reinstating some form of normalcy for civilian populations. This thesis seeks to promote this view of rebel groups, theorizing that rebel justice systems serve as a distinct space for insurgents to routinize interactions with civilians and signal their desire and ability to serve as capable providers of ontological security. Further, I …


Military, Political, Cultural, And Societal Implications Of The Islamic Republic Of Iran’S Passive Defense Strategy, Aaron R. Pilkington Aug 2024

Military, Political, Cultural, And Societal Implications Of The Islamic Republic Of Iran’S Passive Defense Strategy, Aaron R. Pilkington

Electronic Theses and Dissertations

Why did the Islamic Republic of Iran (IRI) adopt a passive defense strategy? This dissertation is the first to trace the institutional development of the IRI’s passive defense strategy and its two Islamic Revolutionary Guards Corps (IRGC)-led executive bodies: the Permanent Committee for Passive Defense (PCPD) and the National Passive Defense Organization (NPDO). Passive defense can be defined simply as defense without weapons, which includes all precautionary actions other than using weapons to minimize the effects of enemy hostile operations that increase deterrence, reduce vulnerability, sustain essential activities, promote national stability, and facilitate crisis management in the face of enemy …


Just Say Gay: An Exploration Of Authenticity And Connection; Queer Identified Therapists’ Lived Experiences Of Identity-Based Self-Disclosure, Courtney Dunne Aug 2024

Just Say Gay: An Exploration Of Authenticity And Connection; Queer Identified Therapists’ Lived Experiences Of Identity-Based Self-Disclosure, Courtney Dunne

Electronic Theses and Dissertations

The current sociopolitical climate in the United States continues to reinforce the complexities and nuances that mental health providers face when facilitating therapy. Over the past few years, anti-DEI legislation has aimed to control the narrative in educational and therapeutic settings regarding what therapists and educators are permitted to teach and share about themselves (Flannery, 2024). At the same time, anti-LGBTQ+ rhetoric continues to dominate the media and further marginalizes individuals whom are in the queer community. In turn, LGBTQ+ individuals continue to face an increased risk for homelessness, substance use disorders, and suicide, which particularly has impacted LGBTQ+ youth …


Paycheck-To-Paycheck: How Public Service Loan Forgiveness Inhibits Generational Wealth Attainment For Black Women, Ashley Patrice-Rose Sherman Aug 2024

Paycheck-To-Paycheck: How Public Service Loan Forgiveness Inhibits Generational Wealth Attainment For Black Women, Ashley Patrice-Rose Sherman

Electronic Theses and Dissertations

Black women who attend college in the United States are more likely to borrow to cover the cost of attendance and carry the largest amount of student loan debt than any other racial and gender group. Federal student loan borrowers are encouraged to work in public service to take advantage of the Public Service Loan Forgiveness Program (PSLF), an income-driven repayment program established by the College Cost Reduction and Access Act (CCRAA) of 2007. PSLF offers total debt relief after ten years of uninterrupted full monthly payments based on an income-driven repayment plan. The significance of this qualitative study will …


Perception Of Crisis Responsibility: Examining Ai-Generated Deepfake Content And Public Response To Taylor Swift, Ziying Chen Aug 2024

Perception Of Crisis Responsibility: Examining Ai-Generated Deepfake Content And Public Response To Taylor Swift, Ziying Chen

Theses - ALL

Due to the increase in deepfake technology, it is crucial to correctly confirm the truthfulness of information, especially in safeguarding reputation during challenging situations. This study applies theoretical frameworks to investigate the impact of deepfake content on the public perception of Taylor Swift, a prominent figure in American pop music. A quantitative content analysis will be conducted to analyze the top tweets produced by social media users (N=131) based on the source of the poster and the nature of the content, such as where the responsibility or blame for the deepfake crisis is attributed. The research explores the effects of …


Examining The Impact Of Stand Your Ground Laws In Alabama, Bruce Litaker Aug 2024

Examining The Impact Of Stand Your Ground Laws In Alabama, Bruce Litaker

Walden Dissertations and Doctoral Studies

It is not known whether gun death rates vary with the implementation of Stand Your Ground (SYG) laws in Alabama. The purpose of this quantitative study was to examine differences in the rate of gun deaths in Alabama since the implementation of SYG laws. Policy feedback theory (PFT) served as a foundational framework and a lens to interpret the research findings. The study was to determine whether there was a statistically significant difference in the firearm homicide rates in all 67 counties in Alabama after SYG implementation, and if there is a statistically significant difference in the firearm homicide rates …


Exploration Of Positive Deviance In Prevention Of Underweight In The Under-Five: A Qualitative Study On Low-Income Urban Families, Irwan Budiono, Lukman Fauzi, Dewi Sari Rochmayani Aug 2024

Exploration Of Positive Deviance In Prevention Of Underweight In The Under-Five: A Qualitative Study On Low-Income Urban Families, Irwan Budiono, Lukman Fauzi, Dewi Sari Rochmayani

Kesmas

Children under the age of five (the under-five) from low-income families are more vulnerable to experience underweight. This nutritional vulnerability is evident in the preliminary study, where 35.1% of the under-five experience underweight, and 28.48% are low-income families. This study aimed to explore Positive Deviance (PD) behaviors in preventing underweight among the under-five. The study applied a qualitative approach with a case study design. Data collection took place in July-August 2022, focusing on low-income families in the Gunung Brintik area. Data were collected through two focus group discussions, seven in-depth interviews, and five key informant interviews. Coding, subtheme, and theme …


Unaccompanied Migrant Children In The Mountain West, 2015-2023, Annie Vong, Caitlin J. Saladino, William E. Brown Jr. Aug 2024

Unaccompanied Migrant Children In The Mountain West, 2015-2023, Annie Vong, Caitlin J. Saladino, William E. Brown Jr.

Demography

This fact sheet examines data on the number of unaccompanied migrant children who obtained sponsors and relocated to 22 cities in five Mountain West states from 2015 to 2023. Data from Arizona, Colorado, Nevada, New Mexico, and Utah are included from a New York Times report which includes U.S. Department of Human Health and Services data on unaccompanied migrant children in all 50 states and Washington D.C.


Comparing Visualization Performance Of Liquid Embolic Agents Using A Novel Injectable Phantom, J Ryan Mason, Cristina Dodge, Adam Beardsley, Susan Hilsenbeck, Goetz Benndorf Aug 2024

Comparing Visualization Performance Of Liquid Embolic Agents Using A Novel Injectable Phantom, J Ryan Mason, Cristina Dodge, Adam Beardsley, Susan Hilsenbeck, Goetz Benndorf

Center for Medical Ethics and Health Policy Staff Publications

Background: Radiographic visualization of liquid embolic agents (LEAs) during embolization procedures in neurovascular territory represents a crucial feature to ensure efficacy and safety for the patients during endovascular treatment of arteriovenous shunting lesions. Radiopacity of available LEAs varies significantly and limited methods are currently available for comparison. The purpose of this study was to compare the contrast resolution (CR) during injection under blank roadmap of various LEAs, as well as standard contrast material.

Methods: An injectable angiographic phantom was designed consisting of parallel tubings between 313 and 1000 micron. Under roadmap, eight radiopaque liquid agents were injected and analyzed: Onyx18®, …


Exploring China’S For-Profit Private Universities From A Stakeholder Perspective : Two Cases From Shanghai, Mian Lin Aug 2024

Exploring China’S For-Profit Private Universities From A Stakeholder Perspective : Two Cases From Shanghai, Mian Lin

Lingnan Theses (Doctoral degree)

China’s higher education has experienced a stage of rapid development since its popularisation over the past two decades. According to the ‘2020 National Statistical Bulletin on Education Development’, China is home to 2,738 general universities. The total number of higher education students reached 41.83 million, and the gross enrolment rate of higher education was 54.4%. Driven by such rapid expansion, the classification management in higher education system become a global issue, it is particularly urgent in China and has increasingly become an important topic in theoretical research and policy practice. Classification management and evaluation of universities to promote the classified …


Acknowledging Dispossession: A Cda/Pda Perspective On Discourse Dealing With Unceded Land, J. R. Martin, Priscilla Angela T. Cruz Aug 2024

Acknowledging Dispossession: A Cda/Pda Perspective On Discourse Dealing With Unceded Land, J. R. Martin, Priscilla Angela T. Cruz

English Faculty Publications

This paper illustrates what can be revealed by a linguistic analysis of the discourse strategies deployed in a bilingual text acknowledging the dispossession of Indigenous peoples in Mindanao (Philippines). The analysis draws on systemic functional linguistics (SFL) descriptions of English, which model language as a resource for making meaning. It explores the choices involved from the perspective of critical discourse analysis (CDA), exposing language in the service of power, and positive discourse analysis (PDA), appreciating language as an instrument of social change. In doing so we exemplify the role of SFL-informed CDA/PDA in processes of reconciliation, including personal and public …


A City Club Report On Measure 117: Ranked Choice Voting, City Club Of Portland (Portland, Or.) Aug 2024

A City Club Report On Measure 117: Ranked Choice Voting, City Club Of Portland (Portland, Or.)

City Club of Portland

For more than a century United States elections have used “plurality voting,” in which the candidate with the most votes wins. Recently, jurisdictions nationwide have introduced varying forms of “ranked choice voting” (RCV) in which the voter ranks the candidates in order of the voter’s preference. In Oregon, Benton County introduced a type of RCV in 2022, and shortly after the City of Corvallis adopted it for races with 3 or more candidates. In the current election (November 2024) voters will use different forms of RCV to choose the 12 members of the new Portland city council, the mayor, and …


Current And Emerging Trends In The Management Of International Disasters, Laura M. Phipps, David A. Mcentire Aug 2024

Current And Emerging Trends In The Management Of International Disasters, Laura M. Phipps, David A. Mcentire

Mavs Open Press Open Educational Resources - Archive

This edited book examines major problems facing the international disaster community as well as innovative solutions to global emergency management, focusing on the current and emerging trends in disaster management that cross geographic, social, and political borders.


How Can Dei Training Change The Culture Of An Organization To Achieve Belonging And Retain Diverse Employees?, Kaisa S. Holt Aug 2024

How Can Dei Training Change The Culture Of An Organization To Achieve Belonging And Retain Diverse Employees?, Kaisa S. Holt

University Honors Theses

Studies show the need for innovation and higher productivity yields can be best achieved through workforce heterogeneity. Creating effective DEI training frameworks is crucial for belonging, sustainable social well-being and enacting real change. This is key to proactively shifting our current system from one that responds to the need for DEI on a surface level to something that is regenerative. The aim of this review is to evaluate characteristics and enhancements added to evidence-based DEI training between 2020 and 2024. Studies were identified using the Portland State advanced database of academic journals on the DEI training and impacts of the …


Msw Portfolio Narrative, Katherine P. Blaedow Aug 2024

Msw Portfolio Narrative, Katherine P. Blaedow

Graduate Student Portfolios, Professional Papers, and Capstone Projects

The Council on Social Work Education and University of Montana School of Social Work require the mastery of ten competencies before graduates are awarded their Master of Social Work degree. In this paper, I share my experiences in mastering these ten competencies and reflect on my graduate degree experience.


Professional Portfolio: A Social Work Journey Through The 10 Competencies, Tessa Rae Nelson Aug 2024

Professional Portfolio: A Social Work Journey Through The 10 Competencies, Tessa Rae Nelson

Graduate Student Portfolios, Professional Papers, and Capstone Projects

The Professional Portfolio demonstrates Tessa Nelson's work through the 10 competencies of social work. This portfolio emphasizes what the student has learned and how it has impacted their social work practice.


What Is The Economic Benefit Of Annual Covid-19 Vaccination From The Adult Individual Perspective?, Sarah M Bartsch, Kelly J O'Shea, Colleen Weatherwax, Ulrich Strych, Kavya Velmurugan, Danielle C John, Maria Elena Bottazzi, Mustafa Hussein, Marie F Martinez, Kevin L Chin, Allan Ciciriello, Jessie Heneghan, Alexis Dibbs, Sheryl A Scannell, Peter J Hotez, Bruce Y Lee Aug 2024

What Is The Economic Benefit Of Annual Covid-19 Vaccination From The Adult Individual Perspective?, Sarah M Bartsch, Kelly J O'Shea, Colleen Weatherwax, Ulrich Strych, Kavya Velmurugan, Danielle C John, Maria Elena Bottazzi, Mustafa Hussein, Marie F Martinez, Kevin L Chin, Allan Ciciriello, Jessie Heneghan, Alexis Dibbs, Sheryl A Scannell, Peter J Hotez, Bruce Y Lee

Center for Medical Ethics and Health Policy Staff Publications

Background: With coronavirus disease 2019 (COVID-19) vaccination no longer mandated by many businesses/organizations, it is now up to individuals to decide whether to get any new boosters/updated vaccines going forward.

Methods: We developed a Markov model representing the potential clinical/economic outcomes from an individual perspective in the United States of getting versus not getting an annual COVID-19 vaccine.

Results: For an 18-49 year old, getting vaccinated at its current price ($60) can save the individual on average $30-$603 if the individual is uninsured and $4-$437 if the individual has private insurance, as long as the starting vaccine efficacy against severe …


South Carolina School District Takeover: A Critical Policy Analysis, David Osworth Aug 2024

South Carolina School District Takeover: A Critical Policy Analysis, David Osworth

Theses and Dissertations

School takeover is a reform strategy where a school or district is placed into the control of a state or municipal government agency. Takeover has become increasingly popular in many states as an attempt to improve schools and district that are struggling either academically or financially. Takeover, however, is more likely to be implemented in districts serving a higher proportion of Black students. Due to the racialized nature of this policy this study uses a Critical Race Theory (CRT) methodology to engage in a critical policy analysis of school takeover in one rural school district in South Carolina. This study …


Unemployment, Weekly Earnings, And Cost Of Living In Mountain West Metros, 2022, Annie Vong, Caitlin J. Saladino, William E. Brown Jr. Aug 2024

Unemployment, Weekly Earnings, And Cost Of Living In Mountain West Metros, 2022, Annie Vong, Caitlin J. Saladino, William E. Brown Jr.

Economic Development & Workforce

This fact sheet examines data on unemployment, weekly earnings, and cost of living for five Metropolitan Statistical Areas (MSAs) in the Mountain West states of Arizona, Colorado, Nevada, and Utah. The Ludwig Institute for Shared Economic Prosperity (LISEP). Local Analysis report includes data on the 50 largest MSAs in the U.S., which include the following in the Mountain West: Phoenix-Mesa Scottsdale, AZ; Tucson, AZ; Denver-Aurora-Lakewood, CO; Las Vegas-Henderson-Paradise, NV; and Salt Lake City, UT.


Projected Job Growth By 2031 In The Mountain West, Madison Dwyer, Annie Vong, Kristian Thymianos, Caitlin J. Saladino, William E. Brown Jr. Aug 2024

Projected Job Growth By 2031 In The Mountain West, Madison Dwyer, Annie Vong, Kristian Thymianos, Caitlin J. Saladino, William E. Brown Jr.

Economic Development & Workforce

This fact sheet examines job growth projections from 2021 to 2031 for the Mountain West states of Arizona, Colorado, Nevada, New Mexico, and Utah. This fact sheet also presents projected job growth data by educational level, and across selected occupational sectors. Data are sourced from the report, “After Everything: Projections of Jobs, Education, and Training Requirements through 2031,” published by the McCourt School of Public Policy’s Center on Education and the Workforce (CEW) at Georgetown University.


Strategic Governance To “Silence The Guns” In Africa: Urban Sub-Saharan African Perceptions On War's Root Causes., Peter Tresor Miyalou, Chun Yan Hu Aug 2024

Strategic Governance To “Silence The Guns” In Africa: Urban Sub-Saharan African Perceptions On War's Root Causes., Peter Tresor Miyalou, Chun Yan Hu

Journal of African Conflicts and Peace Studies

Despite the African Union’s campaign to silence the guns in Africa by 2020 (STGIA 2020), many African countries are suffering from wars and political instability, the primary causes of underdevelopment in Africa. This paper examines the roots causes of wars in Africa and provide a strategic governance to silence the guns beyond 2020. To accomplish this, we gathered data from 169 questionnaire responses administered across 25 African countries, to capture African people’s perceptions on the root causes of wars and whether employing strategic governance would help silence the guns in these countries. The results showed that political power struggle (47.9%), …


Resolving Nigeria’S Security Conundrum: A Comprehensive Regional Analysis, Lukman Ahmed Lawal, Beacon Mbiba, Salamatu Kassah Aug 2024

Resolving Nigeria’S Security Conundrum: A Comprehensive Regional Analysis, Lukman Ahmed Lawal, Beacon Mbiba, Salamatu Kassah

Journal of African Conflicts and Peace Studies

Abstract

This article analyses the regional variabilities of insecurity in Nigeria to propose a suitable approach to understanding their peculiarities. It argues that the dominant military interventions and one-size-fits-all approaches are inappropriate for resolving the country’s myriad security challenges. The Regional Security Complex Theory offers a theoretical basis to contextualise the complex security challenge in Nigeria. There is a need to unbundle the dynamics for each of the regions. Syntheses from the six geopolitical zones indicate that although the security challenges manifest in precarious living conditions, the drivers differ. The article recommends that interventions analyse and identify underlying factors for …


Phase I Trial Of Gd2cart Cells Augmented With Constitutive Interleukin-7 Receptor For Treatment Of High-Grade Pediatric Cns Tumors, Frank Y Lin, Austin Stuckert, Candise Tat, Mark White, Lucia Ruggieri, Huimin Zhang, Birju Mehta, Natalia Lapteva, Zhuyong Mei, Angela Major, Sachin Thakkar, Thomas Shum, Kathan Parikh, Meng-Fen Wu, Holly B Lindsay, Lauren Scherer, Meghan Shekar, Patricia Baxter, Tao Wang, Bambi Grilley, Karen Moeller, John Hicks, Angshumoy Roy, Jamie Anastas, Fatema Malbari, Guillermo Aldave, Murali Chintagumpala, Susan Blaney, D Williams Parsons, Malcolm K Brenner, Helen E Heslop, Cliona M Rooney, Bilal Omer Aug 2024

Phase I Trial Of Gd2cart Cells Augmented With Constitutive Interleukin-7 Receptor For Treatment Of High-Grade Pediatric Cns Tumors, Frank Y Lin, Austin Stuckert, Candise Tat, Mark White, Lucia Ruggieri, Huimin Zhang, Birju Mehta, Natalia Lapteva, Zhuyong Mei, Angela Major, Sachin Thakkar, Thomas Shum, Kathan Parikh, Meng-Fen Wu, Holly B Lindsay, Lauren Scherer, Meghan Shekar, Patricia Baxter, Tao Wang, Bambi Grilley, Karen Moeller, John Hicks, Angshumoy Roy, Jamie Anastas, Fatema Malbari, Guillermo Aldave, Murali Chintagumpala, Susan Blaney, D Williams Parsons, Malcolm K Brenner, Helen E Heslop, Cliona M Rooney, Bilal Omer

Center for Medical Ethics and Health Policy Staff Publications

Purpose: T cells modified with chimeric antigen receptors (CARTs) have demonstrated efficacy for hematologic malignancies; however, benefit for patients with CNS tumors has been limited. To enhance T cell activity against GD2+ CNS malignancies, we modified GD2-directed CART cells (GD2.CARTs) with a constitutively active interleukin (IL)-7 receptor (C7R-GD2.CARTs).

Methods: Patients age 1-21 years with H3K27-altered diffuse midline glioma (DMG) or other recurrent GD2-expressing CNS tumors were eligible for this phase I trial (ClinicalTrials.gov identifier: NCT04099797). All subjects received standard-of-care adjuvant radiation therapy or chemotherapy before study enrollment. The first treatment cohort received GD2.CARTs alone (1 × 107 cells/m2), and …