Digital Commons Network^™

Resting-State Functional Connectivity Correlates Of Attentional Bias In An Emotional Free Viewing Paradigm: An Eye-Tracking Investigation, Andrew Hauler

All NMU Master's Theses

Threat detection, the process of searching complex environments for harmful stimuli, represents a vastly important job that promotes the biological fitness of the organism. Decades of experimental evidence suggests individuals either diagnosed, or at risk for, affective disorders display altered patterns of attentional engagement (hypervigilance or maintenance) with external stimuli; referred to as attentional biases. To date, the extent to which underlying neural mechanisms drive attentional biases, both in affective disorders as well as unselected populations, remain to be resolved. Thus, using eye-tracking and a passive emotional free viewing task, this study set to clarify resting-state network contributions from three …

Biopsychosocial Resilience Through A Complex Adaptive Systems Lens: A Narrative Review Of Nonlinear Modeling Approaches, Adam W. Kiefer, David Pincus

Psychology Faculty Articles and Research

Human resilience is often considered as static traits using a reductionist approach. More recent work has demonstrated it to be a dynamic and emergent property of complex systems. This narrative review explores human resilience through a self-organizing framework with a specific emphasis on the application of nonlinear modeling approaches. Four classes of approaches are examined: univariate dynamics, bivariate coupling, topological modeling, and network modeling. Univariate dynamics capture the temporal structure and flexibility within a single time series, while bivariate coupling approaches quantify the interaction dynamics and coordination between two time series. Topological modeling identifies bifurcations and attractor dynamics as signals …

The Vermont Family Based Approach In Primary Care Pediatrics: Effects On Children’S And Parents’ Emotional And Behavioral Problems And Parents’ Health-Related Quality Of Life, Masha Y. Ivanova, Allison Hall, Stanley Weinberger, Sara L. Buckingham, William E. Copeland, Phoenix Crockett, Justin Dainer-Best, Casey D'Alberto, Lauren Dewey, Deshan Foret, Maria Galano, Lisa Goodrich, Lindsay E. Holly, Nalini Lane, Maureen Leahey, Mathew Lerner, Jasime Marsh, Ellen Mcginnis, Melissa Paiva-Salisbury, Judith S. Shaw, Pamela Swift, Rebekah Tinker, James J. Hudziak

Psychology Faculty Research and Publications

This randomized controlled trial tested the Vermont Family Based Approach (VFBA) in primary care pediatrics. The VFBA is a model of healthcare delivery that shifts the focus from the individual to the family, emphasizes emotional and behavioral health, and uses evidence-based health promotion/prevention along with the treatment of emotional and behavioral problems. Participants were 81 families of 3–15-year-olds. For children, the VFBA was associated with greater reductions than the Control condition on the Child Behavior Checklist Emotionally Reactive, Withdrawn, Sleep Problems, Aggressive Behavior and Total Problems scales. For parents, the VFBA was associated with greater reductions than the Control condition …

The Association Between Symptoms Of Adhd And Alcohol Use And Related Consequences In College Students: Social And Environmental Protective And Risk Factors As Moderators Of This Relation, Cameron Shepard Massey

Theses and Dissertations

Alcohol use, while common in college student populations, can bring about significant mental health and educational problems that have negative consequences (Harris et al., 2017; White & Hingson, 2013). Attention-deficit/hyperactivity disorder (ADHD) can also result in significant impairment in academic settings (Kuriyan et al., 2012; Blase et al., 2009, Barbaresi et al., 2007), and those with ADHD often show increased rates of alcohol consumption and related problems, which can greatly increase the risk for students to struggle in college (Barbaresi et al., 2013; Baker et al., 2012). Examining the impact that specific risk and protective factors play in this relation …

Sustained Attention And Object Manipulation In Autism Spectrum Disorder, Alexis Federico

Theses and Dissertations

Infants interact with their environment from the moment they are born. These interactions can assist in shaping a child’s development, including the skills they gain. Object manipulation has been specifically associated with numerous important outcomes in childhood, such as cognitive skills, motor skills, and language skills. This study aims to characterize object manipulation behaviors at 9 months of age between infants who are at an elevated genetic likelihood for ASD and infants who have no family history of ASD. This study also investigates associations between object manipulation behaviors and a biological measure of attention in both participant groups. While differences …

Electrophysiological Responses To Emotional And Cocaine Cues Reveal Individual Neuroaffective Profiles In Cocaine Users, Heather E Webber, Constanza De Dios, Margaret C Wardle, Robert Suchting, Charles E Green, Joy M Schmitz, Scott D Lane, Francesco Versace

Faculty, Staff and Student Publications

Smokers with stronger neuroaffective responses to drug-related cues compared to non-drug-related pleasant images (C>P) are more vulnerable to compulsive smoking than individuals with the opposite brain reactivity profile (P>C). However, it is unknown if these neurobehavioral profiles exist in individuals abusing other drugs. We tested whether individuals with cocaine use disorder (CUD) show similar neuroaffective profiles to smokers. We also monitored eye movements to assess attentional bias toward cues and we further performed exploratory analyses on demographics, personality, and drug use between profiles. Participants with CUD (n=43) viewed pleasant, unpleasant, cocaine, and neutral images while we recorded electroencephalogram. …

The Aviation Illusion-Situational Judgment Test: Development And Evaluation, John Kleber

Doctoral Dissertations and Master's Theses

Situational judgment tests (SJTs) are scenario-based assessments that evaluate an individual's capacity to make key judgments relating to specific contexts. While SJTs are traditionally used for personal selection (e.g., managers, customer service personnel, and police officers), SJTs also demonstrate potential for use in training evaluation. One area of interest in aviation is aeronautical decision-making (ADM) during inflight encounters with aviation illusions. However, a gap in research exists regarding how to measure pilots’ capacity to make judgments about illusions during flight.

This dissertation aimed to develop and validate an SJT that evaluates aeronautical decision-making (ADM) during inflight encounters with aviation illusions. …

Understanding The Impact Of Adverse Childhood Experiences On Borderline Features And Deliberate Self-Harm Behaviors Among College Students: The Mediating Roles Of Emotion Regulation And Interpersonal Functioning, Sydney Mari Levine

Theses and Dissertations

Research has established ACEs as significant predictors of deliberate self-harm (DSH) in both clinical and community populations. Further, adults meeting criteria for borderline personality disorder (BPD) are nearly 14 times more likely to report childhood adversity. No previous studies have examined the critical roles of emotion regulation and interpersonal functioning as mediating mechanisms in these relations. Thus, the current study explored the mechanism by which ACEs affect borderline personality features (BPF) or deliberate self-harm through emotion regulation and interpersonal functioning in a sample of emerging adult college students. Participants (N = 2,255, M age = 19.25) included college students from …

Social Anhedonia, Communication And Marital Satisfaction In Newlywed Couples, Kenneth Tan, Amber M. Jarnecke, Susan C. South

Research Collection School of Social Sciences

Objective: Social anhedonia is associated with disinterest in social interactions and poor relationship functioning, yet little is known about the specific mechanisms underlying associations between social anhedonia and romantic relationship behaviors and satisfaction. We examined the links between social anhedonia, perceptions of conflict communication patterns, and marital satisfaction. Method: The current research examined the role of social anhedonia on marital quality and functioning longitudinally across a year in a sample of 100 newlywed couples using an actor-partner interdependence framework. Results: Social anhedonia was negatively associated with own and partner's marital satisfaction. It was also negatively associated with constructive communication and …

What's Your Type? The Relationship Between Enneagram Personality Style And Psychiatric Diagnosis, Danielle Augusta Huber

Theses and Dissertations

Despite its long history and ever-growing popularity amongst mental health providers and laypeople, the Enneagram model of personality has seen limited empirical support regarding its clinical relevance and efficacy. The present study sought to contribute to the literature supporting the Enneagram’s use in psychotherapy. As a majority of therapeutic services aim for the reduction and/or resolution of psychopathology, often in terms of one or more diagnoses, and as previous research has theorized how the Enneagram model and psychiatric diagnoses might be related (Palmer, 1988), it was the researchers’ intention to analyze whether these theoretical associations could be statistically supported. This …

Experiences Of The Supervisory Alliance And Self-Compassion In Counseling And Psychotherapy Students, Alexandre Brien, Patricia Dionne, Réginald Savard, Cynthia Bilodeau

Journal of Counselor Preparation and Supervision

This qualitative research examined the relationship between supervisory working alliance, self-compassion and reflexive self-awareness with students enrolled in a graduate-level counseling or counseling and psychotherapy program (n = 48). A thematic analysis using a Critical Incident Questionnaire was performed. The themes identified in this study indicate that both supervision alliance and self-compassion seemingly contribute positively to student supervisee learning experiences and to the development of their reflexive self-awareness. Moreover, the perceived learning achieved, and the development of reflexive self-awareness, reciprocally strengthened the supervisory alliance. Furthermore, the degree of supervisees’ self-compassion as well as their perceived supervisory alliances had an …

The Impact Of Biological Sex On Motor Function And Responses To Novel Environments In The Gray Short-Tailed Opossum (Monodelphis Domestica), Esperanza I. Alaniz, Ismael Perez, Sasawan Heingraj, Katelynn Renteria, Cristian M. Botello, Joseph C. Cantu, John L. Vandeberg, Mario Gil

Research Symposium

Background: Understanding the different stress reactions in different environments can help us understand stress factors. Studying animal behavior is important for translational research for mental health improvement.

Previous literature has shown that stress is a risk factor for higher cancer incidence and poorer cancer survival. (Klejbor & Turlejski., 2012), as well as mental health outcomes. Understanding of how stress is related to cancer can help improve therapeutic outcomes as preventive measures (Glaser et al., 1987).

Methods: Using the Rota Rod apparatus, 12 animals (3 males, 9 females) were tested at 36 rpm for a maximum of 400 seconds (Madroñal et …

A Neurodevelopmental Perspective To Improve Innovation In Preventive Treatment Of Substance Use Disorders, Ismael Perez, John Vandeberg, Mario Gil

Research Symposium

Background: Midbrain dopaminergic neurons have been associated with substance use disorders (Blaess & Ang, 2015). Understanding their neurodevelopment during early stages of life is fundamental for innovating preventive care treatments. The animal model Monodelphis domestica has been proposed as an excellent candidate to study neurodevelopmental changes due to the ease of access to see changes in their embryonic development (Mate et al., 1994). The purpose of our study is to inform how brain cells, including and especially dopaminergic neurons, mature by quantifying their number during early development. Additionally, the study aims to compare different midbrain areas and track neurodevelopmental changes …

The Impact Of Social Isolation On The Neural Pathways Of Dopamine Neurons In The Ventral Tegmental Area (Vta) And The Nucelus Accumbens (Nac): Implications For The Treatment Of Depression, Anxiety, And Drug Addiction., Cristian M. Botello, Sasawan Heingraj, John L. Vandeberg, Mario Gil

Research Symposium

As the literature on the Monodelphis domestica continues to grow, it is important to contribute to the knowledge base regarding neural pathways and their role in social behavior in this species. Previous studies have provided evidence that increased activity in ventral tegmental area (VTA) dopamine neurons were associated with more social activity in mice. It is also known that in traditional rodent models, the Nucleus Accumbens (NAcc) is implicated in interaction reward processes like motivation; however, more research is needed to elucidate the role of the NAcc in social behavior of the M. domestica. The present study was designed …

Mixed Method Approach Towards The Life Of University Students During The Covid-19 Pandemic, Raihan Khan, Andrew White, Tony Jehi

Department of Health Sciences - Faculty Scholarship

Background

The COVID-19 pandemic negatively impacted the higher education system. This mixed-methods study aimed to assess COVID-19 fear, anxiety, and stress among Shenandoah Valley college students.

Methods

An online survey was fielded and completed by n=680 students. Qualitative semi-structured interviews were conducted with 20 students.

Results

The mean participant age was 22.14±5.48 years, and primarily White (81.9%), women (80.4%), and undergraduate (78.0%) students. Approximately 41% were enrolled in health-related majors (41.4%). Women students had significantly higher anxiety, depression, and fear of contracting COVID-19 than men. Undergraduate students had significantly higher depression than graduate students. Qualitative analysis revealed several major themes: …

Does Using Clicker Questions Improve Students' Conceptual Understanding?, Edward W. Goshorn Iv

The Cardinal Edge

Active learning can be incorporated into STEM classrooms in multiple ways. With exploratory learning, students explore a novel activity before learning the concepts or procedures. With personal response devices (e.g., clickers), students respond to real-time questions posed during lecture. The current studies examined whether, and how, clicker question can be used as exploratory learning, to improve students’ conceptual understanding and engagement over traditional instruction. Biology professors integrated clicker questions into a lecture, and either closed the clicker poll prior to (Restricted Clicker Experiment, N = 164) or after (Extended Clicker Experiment, N = 188) giving feedback to the class. Undergraduate …

Who Gives The Cookies And Who Gets The Grade: Children's Judgements On Intersecting Identities, Brianna Walker, Anabel Puri

The Cardinal Edge

The Stereotype Content Model (SCM) suggests that group stereotypes are reflect differences in warmth and competence. (Fisk et al. 2001). Many studies primarily use White men as a baseline for understanding these judgements of race and gender without combining these identities. We aim to examine how children assess individuals from various race and gender groups. Participants included 90 children ranging from age 5-10. Children were asked to rate individuals with different identities (e.g., White man, Black woman, etc.) on the dimensions of warmth and competence. Children were then asked to compare individuals with different identities and determine which person was …

The Science Of Learning: Understanding The Learning Process And Its Implementation Into The Classroom, Robert Hawkins

The Cardinal Edge

College and higher education is often seen as the next step for many students pursuing a particular career or field. These institutions strive to facilitate learning and maintain a rewarding academic environment. However, students often face various challenges when first attending college which is reflected by high levels of dropout and withdrawal from general education courses, especially for first-time students. In fact, according to the education data initiation, “at 4-year institutions, 18.4% of first-time, full-time college freshmen dropped out between 2019 and 2020” (Hansen & Checked, 2022). One of these challenges is understanding the process of learning on a fundamental …

With A Little Help At Home: The Impact Of Romantic Partner Support On Daily Burnout And Workplace Incivility, Matthew Aplin-Houtz

Dissertations

With rude and discourteous encounters in the workplace becoming more common, Workplace incivility (WI) is at an all-time high. As such, workers experience levels of burnout from these negative social interactions. The literature concedes that the results of these interactions lead to mounting burnout, causing negative physical and emotional outcomes at the individual and organizational levels. Considering that the literature also supports that employees have the potential to recover from burnout symptoms through rest, obtaining the perception of control of their circumstances, and cognitive reframing, the time and activities a worker spends at home carry the potential for minimizing burnout …

Preparing Counselors To Meet The Needs Of Transgender Clients, Kristy Carangi

Antioch University Dissertations & Theses

This exploratory quantitative study tests the effectiveness of a three-hour Transgender Training Intervention for increasing the gender identity competence of counselors and counselors-in-training. Participants (N = 4) were recruited online and completed the 20-item Counselor Competence Gender Identity Survey (CCGIS) before and after the virtual training intervention. Data were analyzed using descriptive statistics. Results indicated that mean total CCGIS scores increased from 127.0 in the pretest to 138.75 in the posttest, a 9.25% increase. The largest gains were made on the Gaining Knowledge/Skills to Counsel Gender Diverse Individuals subscale (CCGIS-KS). Mean scores on the CCGIS-KS increased from 24.25 in the …

Cumulative Incidence Of Physical And Sexual Dating Violence: Insights From A Long-Term Longitudinal Study, Jeff R Temple, Elizabeth Baumler, Leila Wood, Kelli Sargent Franco, Melissa Peskin, Christie Shumate

Faculty, Staff and Student Publications

Decades of inquiry on intimate partner violence show consistent results: violence is woefully common and psychologically and economically costly. Policy to prevent and effectively intervene upon such violence hinges upon comprehensive understanding of this phenomenon at a population level. The current study prospectively estimates the cumulative incidence of sexual and physical dating violence (DV) victimization/perpetration over a 12-year timeframe (2010–2021) using diverse participants assessed annually from age 15 to 26. Data are from Waves 1–13 of an ongoing longitudinal study. Since 2010 (except for 2018 and 2019), participants were assessed on past-year physical and sexual DV victimization and perpetration. Participants …

The Creative Arts Personal Growth Group With Centering Prayer For Sexual Trauma Survivors: A Transformative-Coping Focused Interpretative Phenomenological Analysis Study, Rachel M. Parrish-Martin

Doctoral Dissertations and Projects

Copious research demonstrates an epidemic of sexual trauma (ST) among females resulting in excruciating shame and fear of exposing oneself to others. Shame is an under-researched emerging mental health concern. This study addressed a gap in the literature regarding interventions for shame symptoms experienced by female survivors of ST. Specifically, it was an intervention study that applied a spiritually integrated form of the Creative Arts Personal Growth Group (CAPG) with Centering Prayer (CAPG-CP). Utilizing the Theory of Transformative Coping and Interpretative Phenomenological Analysis, this study explored the lived experience of nine female Christian ST survivors who participated in the CAPG-CP. …

The Lived Experience Of Residential Undergraduates From Minority Ethnic Backgrounds Diagnosed With A Mental Health Condition, Cheryl Gowdie

Doctoral Dissertations and Projects

Research has demonstrated that mental health illnesses have increased, particularly among college students. Although there is a general understanding of the implications of this trend, there remains a lack of evidence on the impact of mental health diagnoses on residential undergraduate minority ethnic students. This qualitative phenomenological study aims to gain insight into the lived experiences of 10 residential undergraduate minority students aged 18 to 36 diagnosed with one or more mental health disorders. The goal is to understand their personal experiences, including any stigma they may have encountered. Through comprehensive interviews, the study explored their lived experiences. The findings …

Returning To School After Covid-19: Relationships Between Parental Stress And Resilience With Children’S Mental Health Behaviors, Christa P. Stanley

Doctoral Dissertations and Projects

During the COVID-19 lockdowns, experts predicted an increase of children’s mental health issues. However, not all children showed symptoms after lockdowns lifted. The study’s purpose was to examine parental stress and resilience during COVID-19 lockdowns and their relationship to children’s behaviors, specifically anxiety and aggression after lockdown. Participants included 61 parents of children currently aged 7-11 who did not have mental health disorders before COVID lockdowns. Most parents were white, non-Hispanic within middle to high income ranges. The quantitative study used a correlational design. Parents were recruited through school websites and social media sites which linked them to a 122-question …

Editorial Postscript

The International Journal of Ecopsychology (IJE)

No abstract provided.

A Phenome-Wide Association Study (Phewas) Of Late Onset Alzheimer Disease Genetic Risk In Children Of European Ancestry At Middle Childhood: Results From The Abcd Study®, Aaron Gorelik

Arts & Sciences Graduate Student Theses and Dissertations

Genetic risk for Late Onset Alzheimer Disease (AD) has been associated with lower cognition and smaller hippocampal volume in healthy young adults. However, whether these and other associations are present during childhood remains unclear. Using data from 5,556 genomically-confirmed European ancestry youth who completed the baseline session of the ongoing the Adolescent Brain Cognitive Development^SM Study (ABCD Study^®), our phenome-wide association study estimating associations between four indices of genetic risk for late-onset AD (i.e., AD polygenic risk scores (PRS), APOE rs429358 genotype, AD PRS with the APOE region removed (AD_PRS-APOE), and an interaction between AD …

Theories Of Consciousness And A Life Worth Living, Liad Mudrik, Myrto Mylopoulos, Niccolo Negro, Aaron Schurger

Psychology Faculty Articles and Research

What is it that makes a life valuable? A popular view is that life’s moral worth depends in some way on its relationship to consciousness or subjective experience. But a practical application of this view requires the ability to test for consciousness, which is currently lacking. Here, we examine how theories of consciousness (ToCs) can help do so, focusing especially on difficult cases where the answer is not clear (e.g. fetuses, nonhuman animals, unresponsive brain-injured patients, and advanced artificial systems). We consider five major ToCs and what predictions they offer: Integrated information theory, Higher-Order Thought Theory, Recurrent Processing Theory, Global …

Acculturation And Subjective Norms Impact Non-Prescription Antibiotic Use Among Hispanic Patients In The United States, Lindsey A Laytner, Kiara Olmeda, Juanita Salinas, Osvaldo Alquicira, Susan Nash, Roger Zoorob, Michael K Paasche-Orlow, Barbara W Trautner, Larissa Grigoryan

Faculty, Staff and Students Publications

Using antibiotics without medical guidance (non-prescription antibiotic use) may contribute to antimicrobial resistance. Hispanic individuals are a growing demographic group in the United States (US) with a high prevalence of non-prescription antibiotic use. We investigated the effects of acculturation and subjective norms on Hispanic individuals’ intentions to use antibiotics without a prescription from the following sources: (1) markets in the United States (not legal), (2) other countries (abroad), (3) leftovers from previous prescriptions, and (4) friends/relatives. We surveyed self-identified Hispanic outpatients in eight clinics from January 2020 to June 2021 using the previously validated Short Acculturation Scale for Hispanics (SASH). …

Culturally Responsive Practices In Graduate Training: Challenges, Strategies, And Recommendations, Khadija Ali, Jolinpreet Dhami, Odessa Luna

The Journal of Advancing Education Practice

This paper examines three women of color perspectives on the relevance of incorporating culture and race discussions, activities, and assignments into graduate courses. The authors provide a description of their upbringing to highlight how their personal experiences shaped their perspective on culture and race in educational settings. The challenges of delivering instruction to encompass culture are discussed alongside a student’s evaluation of these barriers. In addition, instructors outline strategies they have implemented to incorporate a culturally responsive practice. Lastly, the authors present recommendations to urge other faculty members and students to use and advocate for culturally responsive practices.

Multiancestry Analysis Of The Hla Locus In Alzheimer’S And Parkinson’S Diseases Uncovers A Shared Adaptive Immune Response Mediated By Hla-Drb1*04 Subtypes, Yann Le Guen, Guo Luo, Aditya Ambati, Vincent Damotte, Iris Jansen, Eric Yu, Aude Nicolas, Itziar De Rojas, Thiago Peixoto Leal, Akinori Miyashita, Céline Bellenguez, Michelle Mulan Lian, Kayenat Parveen, Takashi Morizono, Hyeonseul Park, Benjamin Grenier-Boley, Tatsuhiko Naito, Fahri Küçükali, Seth D Talyansky, Selina Maria Yogeshwar, Vicente Sempere, Wataru Satake, Victoria Alvarez, Beatrice Arosio, Michael E Belloy, Luisa Benussi, Anne Boland, Barbara Borroni, María J Bullido, Paolo Caffarra, Jordi Clarimon, Antonio Daniele, Daniel Darling, Stéphanie Debette, Jean-François Deleuze, Martin Dichgans, Carole Dufouil, Emmanuel During, Emrah Düzel, Daniela Galimberti, Guillermo Garcia-Ribas, José María García-Alberca, Pablo García-González, Vilmantas Giedraitis, Oliver Goldhardt, Caroline Graff, Edna Grünblatt, Olivier Hanon, Lucrezia Hausner, Stefanie Heilmann-Heimbach, Henne Holstege, Jakub Hort, Yoo Jin Jung, Deckert Jürgen, Silke Kern, Teemu Kuulasmaa, Kun Ho Lee, Ling Lin, Carlo Masullo, Patrizia Mecocci, Shima Mehrabian, Alexandre De Mendonça, Mercè Boada, Pablo Mir, Susanne Moebus, Fermin Moreno, Benedetta Nacmias, Gael Nicolas, Shumpei Niida, Børge G Nordestgaard, Goran Papenberg, Janne Papma, Lucilla Parnetti, Florence Pasquier, Pau Pastor, Oliver Peters, Yolande A L Pijnenburg, Gerard Piñol-Ripoll, Julius Popp, Laura Molina Porcel, Raquel Puerta, Jordi Pérez-Tur, Innocenzo Rainero, Inez Ramakers, Luis M Real, Steffi Riedel-Heller, Eloy Rodriguez-Rodriguez, Owen A Ross, Luis Jose Royo, Dan Rujescu, Nikolaos Scarmeas, Philip Scheltens, Norbert Scherbaum, Anja Schneider, Davide Seripa, Ingmar Skoog, Vincenzo Solfrizzi, Gianfranco Spalletta, Alessio Squassina, John Van Swieten, Raquel Sánchez-Valle, Eng-King Tan, Thomas Tegos, Charlotte Teunissen, Jesper Qvist Thomassen, Lucio Tremolizzo, Martin Vyhnalek, Frans Verhey, Margda Waern, Jens Wiltfang, Jing Zhang, Eadb, Gr@Ace Study Group, Degesco Consortium, Demgene, Eadi, Gerad, Asian Parkinson’S Disease Genetics Consortium, Henrik Zetterberg, Kaj Blennow, Zihuai He, Julie Williams, Philippe Amouyel, Frank Jessen, Patrick G Kehoe, Ole A Andreassen, Cornelia Van Duin, Magda Tsolaki, Pascual Sánchez-Juan, Ruth Frikke-Schmidt, Kristel Sleegers, Tatsushi Toda, Anna Zettergren, Martin Ingelsson, Yukinori Okada, Giacomina Rossi, Mikko Hiltunen, Jungsoo Gim, Kouichi Ozaki, Rebecca Sims, Jia Nee Foo, Wiesje Van Der Flier, Takeshi Ikeuchi, Alfredo Ramirez, Ignacio Mata, Agustín Ruiz, Ziv Gan-Or, Jean-Charles Lambert, Michael D Greicius, Emmanuel Mignot

Faculty, Staff and Students Publications

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. …