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Iptakalim Attenuates Self-Administration And Acquired Goal-Tracking Behavior Controlled By Nicotine, S. Charntikov, N. Swalve, Steven T. Pittenger, K. Fink, S. Schepers, G. C. Hadlock, A. E. Fleckenstein, G. Hu, Ming Li, Rick A. Bevins

Department of Psychology: Faculty Publications

Iptakalim is an ATP-sensitive potassium channel opener, as well as an a4b2-containing nicotinic acetylcholine receptor (nAChR) antagonist. Pretreatment with iptakalim diminishes nicotine-induced dopamine (DA) and glutamate release in the nucleus accumbens. This neuropharmacological profile suggests that iptakalim may be useful for treatment of nicotine dependence. Thus, we examined the effects of iptakalim in two preclinical models. First, the impact of iptakalim on the interoceptive stimulus effect of nicotine was evaluated by training rats in a discriminated goal-tracking task that included intermixed nicotine (0.4 mg/kg, SC) and saline sessions. Sucrose was intermittently presented in a responseindependent manner only on nicotine sessions. …

Expanding The Ecological Lens In Child Welfare Practice To Include Other Animals, Christina Risley-Curtiss

The Journal of Sociology & Social Welfare

Sixty-nine million U.S. households have companion animals and most of these families consider these animals to be family members. Research shows that children have powerful emotional connections with animals that can be both beneficial and harmful. Considerable research findings report that violence against animals often co-occurs with, indicates, or predicts other forms of family violence, including child abuse. A companion animal may be an abused child's confidante, and separation from that animal through foster care may be a source of stress and grief for that child. Child welfare agencies are slowly acknowledging some animal-human relationships, especially in regard to animal …

Evaluation Of The Efficacy Of A Rat Agreement Based Reinforcement Procedure, Katherine B. Lalonde

Masters Theses

Since 2007, giant African pouched rats (Cricetomys gambianus) have been used successfullyfor detecting Tuberculosis (TB) positive patients.The rats are trained to detect TB-positive sputum samples through the use of operant conditioning techniques, in which an indicator response is rewarded with food. If the rats are to be used for first line screening of patients reinforcement could not be provided because the true status of the sample would be unknown. The present study evaluated the effects of a reinforcement-for-agreement procedure that could be used to reinforce indication responses when the true status of the sample is unknown. Four rats evaluated 100 …

A Good Old Age: Experiencing A Satisfying Life, Kaitlin Thimann

Boise State University Theses and Dissertations

The definition of successful aging has been changing, however, there is a lack of current studies on existing aging trends and how to experience a good old age. The purpose of this study is to identify and describe themes and factors that can lead to an individual experiencing a good old age. This study is a qualitative, exploratory ethnography in which interviews were used to gather information on a good old age from adults aged sixty-five and older. The study revealed that there were several common factors throughout the interviews. Physical and mental health, social support, and financial stability are …

A Multimedia Intervention To Increase The Likelihood That University Students In Need Will Utilize Counseling Services, Todd W. Lindsley

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The primary objective of this study was to create and test an intervention designed to increase students’ positive attitudes toward utilizing mental health services. A review of the literature was conducted to establish the guidelines for creating an intervention that would effectively influence attitudes while being relatively easy to customize and adapt to different settings. The content of the intervention was informed by the literature, reviewed by a panel of experts, and tested with a focus group of students before being finalized. In order to test the effectiveness of the intervention, and experimental study was designed which included an experimental …

Influences Of Tnt-Food Pairings On The Performance Of Mine Detection Rats In Early Training Stages, Timothy L. Edwards

Dissertations

Anti-Persoonsmijnen Ontmijnende Product Ontwikkeling (APOPO), a Belgian nongovernmental organization headquartered in Tanzania, trains giant African pouched rats (Cricetomys gambianus) to detect land mines and deploys the rats for operational use in countries afflicted with mines and explosive remnants of war. In the present study an evaluation of the influence of ongoing scent-food pairings on the performance of the rats in early mine detection training was conducted. Twenty young rats in APOPO’s mine detection rat program were divided into two groups and exposed to five daily stimulus-food pairing sessions each week. For the experimental group the stimulus was the …

Evaluation Of Modafinil In Preclinical Behavioral Assays Of Abuse Liability, Amanda J. Quisenberry

Dissertations

Modafinil is an FDA-approved drug for the treatment of narcolepsy with efficacy in the treatment of chronic fatigue syndrome, obstructive sleep apnea, and shift-work sleep disorder. Modafinil’s wake-promoting and cognitiveenhancing effects are reportedly similar to those of traditional psychostimulants, but without the side effects typically associated with these substances. Modafinil has also been investigated as an agonist replacement therapy for psychostimulant dependence, although results of clinical trials are equivocal. Few studies have examined its behavioral effects in combination with psychostimulants and the neuropharmacological actions of modafinil are not well understood. The primary aim of this study was to assess modafinil’s …

Dehumanization: As It Is Present Within Bullying Behaviors In An Anti-Bullying Program, Katelyn Amos

UNLV Theses, Dissertations, Professional Papers, and Capstones

Bullying is an aggressive act performed repeatedly on another enacting a power differential. This thesis utilized data collected from The Anti-Bullying Prevention Pilot Program (ABPPP), which studied bullying within eleven schools in a large metropolitan area in southwestern United States. The program was aimed to increase positive school climate through the use of Operation Respect and Welcoming Schools programs.

Consensual Qualitative Research (CQR) and mixed methods approaches were used in order to analyze interviews and questionnaires. Grounded Theory analysis procedures were used to code the information, and thick descriptions were utilized to illustrate the occurrence of dehumanization among across four …

Examining The Relationships Between Internalizing And Externalizing Problems And Academic Achievement, Lara Elizabeth Conrad

UNLV Theses, Dissertations, Professional Papers, and Capstones

The relationship between internalizing and externalizing problems and academic achievement for children and adolescents has been inconclusive. Particularly the relationship between the Behavior Assessment System for Children, Second Edition (BASC-2) reports of internalizing and externalizing problems and academic performance on the Woodcock-Johnson, Tests of Achievement, Third Edition (WJ-III:ACH). The current study examined the self and parent reports of internalizing and externalizing problems as measured by the BASC-2 and the relationship with academic skills as measured by the WJ-III:ACH. The referral source (private practice or school setting) was evaluated for severity of presenting internalizing and externalizing symptoms. Secondary data analysis was …

What Works In Suicide Bereavement: What Helps And What Hurts?, Quintin Hunt

UNLV Theses, Dissertations, Professional Papers, and Capstones

Suicide is one of the most painful grief experiences that any family may experience. The suicide bereavement literature, though small, is replete with research that shows family and systemic impacts of suicide. The literature also includes constant calls for family- and systemic-based intervention as every part of society is impacted. Research in the field of marriage and family therapy, however, has ignored suicide and suicide bereavement almost entirely. The purpose of this qualitative study is to develop a more thorough understand of the grief that survivors of suicide experience and to systemically understand what helps and hurts the grieving process. …

“Mad-Speak” And Manic Prose: Nick Cave’S Presentation Of Insanity In And The Ass Saw The Angel, Laura Hardt (Class Of 2014)

English Undergraduate Publications

Nick Cave’s novel And the Ass Saw the Angel attempts to exist firmly within the Southern Gothic tradition, pulling direct inspiration from authors such as William Faulkner, Cormac McCarthy, and Flannery O’Connor. However, Cave’s novel seems to lack the careful construction and purposefulness of these writers, with its graphic violence, constantly shifting tone, style, narrative voice, and employing an utterly bizarre and arcane vocabulary. This essay aims to illustrate that although this may make the work seem poorly composed and somewhat slipshod, the manic prose of Cave’s novel is actually rather purposeful, presenting the protagonist’s descent into madness in an …

Perceived Satisfaction Of Equine-Assisted Therapy: A Qualitative Study Of Family Narratives, Morgan N. Carriker

Senior Honors Theses

The present research represents the satisfaction that parents feel with equine-assisted therapy. Equine-assisted therapy is, according to Funk and Smith (2000), the use of horses as a therapy technique that improves the well-being of individuals in all of the following areas: social, cognitive, psychosocial, and physical (2000). Themes were coded from publicized material that contained accounts of parents whose children participated in a specific equine-assisted therapy program in North Carolina. Each testimony was coded for themes that were similar in nature to those that were represented in other accounts as well. Themes that were found were organized into categories and …

Methylphenidate Conditioned Place Preference In Juvenile And Adolescent Male And Female Rats, Elizabeth D. Freeman

Electronic Theses and Dissertations

This investigation was an analysis of the effects of methylphenidate (MPH; trade name: Ritalin) on drug reward using the conditioned place preference (CPP) behavioral paradigm in a rodent model and underlying mechanisms of this effect. Animals were conditioned in adolescence from postnatal day (P)33-39) or P44-49 with saline, 1 or 5 mg/kg MPH. Rats administered 5 mg/kg but not 1 mg/kg MPH, resulted in a significant preference that was more robust in younger male adolescent rats. The 5 mg/kg dose of MPH also resulted in a significant decrease of the dopamine transporter in both the nucleus accumbens and striatum, revealing …

Seasonal And Diurnal Behavioral Patterns Of Bottlenose Dolphins, Tursiops Truncatus, That Exhibit High Site And Low Site Fidelity To Mississippi Sound, Shauna Marisa Mcbride

Master's Theses

This study examined whether bottlenose dolphins (Tursiops truncatus) exhibit site fidelity to the Mississippi Sound and how the seasonal and diurnal behavioral patterns of dolphins that exhibit high site fidelity to the Mississippi Sound differ from those of dolphins with lower site fidelity. Opportunistic surveys conducted from July 2006 to April 2010 were analyzed. Statistical analyses consisted of nonparametric tests (Spearman's correlation, loglinear models, and Pearson's chi-square) to compare behavioral patterns of high site fidelity, mixed, and low site fidelity groups. Behavioral patterns significantly differed between site fidelity groups across seasons and diurnal periods. Feeding behavior was observed significantly more …

Corpus Callosal Microstructure Influences Intermanual Transfer In Chimpanzees, Kimberley A. Phillips, J. Schaeffer, William D. Hopkins

Psychology Faculty Research

Learning a new motor skill with one hand typically results in performance improvements in the alternate hand. The neural substrates involved with this skill acquisition are poorly understood. We combined behavioral testing and non-invasive brain imaging to study how the organization of the corpus callosum was related to intermanual transfer performance in chimpanzees. Fifty-three chimpanzees were tested for intermanual transfer of learning using a bent-wire task. Magnetic resonance and diffusion tensor images were collected from 39 of these subjects. The dominant hand showed greater performance benefits than the nondominant hand. Further, performance was associated with structural integrity of the motor …

Effects Of Trauma Induced Stress On Attention, Executive Functioning, Processing Speed, And Resilience In Urban Children, Antoinette Welsh

Seton Hall University Dissertations and Theses (ETDs)

Brain development, and particularly structures involved in executive functioning, occurs at different rates in children, leading to differential performance in school. Due to neuroanatomical changes secondary to the stress response, children who have experienced stress as a result of poverty and traumatic events may be at increased risk for cognitive difficulties, including attention, executive functioning, and processing speed (Blair, Granger, & Razza, 2005; DeBellis, Hooper, & Sapia, 2005). Prevalence rates among urban children suggest that 70-100% have been exposed to trauma (Dempsey, Overstreet, & Moely, 2000; Macy, Baryry, & Noam, 2003). Some of these children develop posttraumatic stress disorder and …

Human Action Switching In Hiv, Chinonyere Nzerem

Loma Linda University Electronic Theses, Dissertations & Projects

We evaluated switching in human action/verb fluency to examine how it associates with other measures of executive functioning and with difficulties in the performance of IADLs in a HIV+ sample. Our sample was comprised of 29 HIV+ participants. All the participants completed measures of phonetic fluency (FAS) and semantic fluency [Animals, Human Actions (HA)] in addition to the Paced Auditory Serial Addition Test (PASAT), Stroop Color-Word Test (Stroop), Trail-making Test Part B (TMT B), Letter-Number Sequencing (LNS), Wisconsin Card Sorting Test, and the Boston Naming Task (BNT). The first regression model with phonetic and semantic switching produced R2 = .260, …

Combining Attentional Control And Semantic Memory Retrieval: A Sensitive Marker For Early Stage Ad And Ad-Related Biomarkers In Healthy Older Adults, Andrew Jacob Aschenbrenner

All Theses and Dissertations (ETDs)

Past studies have shown that measures of attentional control and semantic memory retrieval are sensitive markers of Alzheimer disease: AD). The present study examined the utility of combining measures of attentional control and semantic retrieval within a single task to discriminate healthy aging from early stage AD and show sensitivity to AD biomarkers in healthy control individuals. On each trial of the present task, participants viewed a category: e.g. “a unit of time”) and verified whether a subsequent target item was an exemplar of the category: “hour”) or not: “clock”). Importantly, the nonmembers of the category were associatively related: e.g., …

The Effect Of Age-Related Declines In Inhibitory Control On Audiovisual Speech Intelligibility, Avanti Dey

All Theses and Dissertations (ETDs)

Audiovisual: AV) speech perception is perception in which both auditory and visual information is available in order to understand a talker, compared to an auditory signal alone, during face-to-face communication. This form of communication yields significantly higher word recognition performance as compared to either sensory modality alone, constituting a general AV advantage for speech perception. Despite an overall AV advantage, older adults seem to receive less benefit from this bimodal presentation than do younger adults. However, there is evidence to suggest that not all age-related deficits in AV speech perception are of a sensory nature, but are also influenced by …

Will A Confederate's Initial Decline Of Assistance Influence People's Willingness To Help Others?, Israel Vela

Theses and Dissertations - UTB/UTPA

Observational study testing the effect a confederate has on social influence. The study examined whether overhearing a prior refusal to assist from a confederate had an influence on a subsequent person’s willingness to help in time of need. Similarity characteristics between model and participant were also examined to determine if they contributed to an increased likelihood of helping. Observation was held at the University of Texas-Pan American and consisted of 60 male participants. Participants were approached, and asked for assistance, in two separate conditions: Experimental (confederate) condition (n=30) and Control (non-confederate) condition (n=30). Assistance was determined by a participant’s willingness …

The Separate And Combined Effects Of Heredity And Environment Predicting Alcohol Use Disorder Symptoms And Antisocial Personality Disorder Symptoms, Jaylee R. Gill

Honors Theses

The current study examined genetic and environmental influences in relation to alcohol use pathology. The 756 participants (378 adoptive, 378 non-adoptive) came from the 2001-2002 NESARC conducted by the NIAAA. A factorial ANOVA was used to measure the effects that the three grouping variables had on each dependent variable for a total of seven datasets. Results showed that biological parents’ drinking did pose a risk in participants for Loss of Control (p = .000) and Dangerous Behavior (p = .00). Adoption status was correlated with Conduct Disorder (p = .007) and Antisocial Personality Disorder (p = .014). This suggests that …

Functional And Structural Changes Throughout The Auditory System Following Congenital And Early-Onset Deafness: Implications For Hearing Restoration, Blake E. Butler, Stephen G. Lombar

Brain and Mind Institute Researchers' Publications

The absence of auditory input, particularly during development, causes widespread changes in the structure and function of the auditory system, extending from peripheral structures into auditory cortex. In humans, the consequences of these changes are far-reaching and often include detriments to language acquisition, and associated psychosocial issues.Much of what is currently known about the nature of deafness-related changes to auditory structures comes from studies of congenitally deaf or early-deafened animal models. Fortunately, the mammalian auditory system shows a high degree of preservation among species, allowing for generalization from these models to the human auditory system. This review begins with a …

Laterality Influences Schooling Position In Rainbowfish, Melanotaenia Spp, Anne-Laurence Bibost, Culum Brown

Aquaculture Collection

Cerebral lateralization is a widespread trait among animals, is often manifested as side biases in behaviour (laterality) and has been suggested to provide fitness benefits. Here we examined the influence of laterality on the organisation of fish schools using rainbowfish (Melanotaenia spp) as model species. The pattern and strength of laterality for each individual was determined by examining eye preferences whilst examining their reflection in a mirror. Schools of four fish of known laterality were then created and the preferred position for each fish within the school was repeatedly observed in a flume. Fish which showed right eye preferences in …

Bdnf In The Dentate Gyrus Is Required For Consolidation Of "Pattern-Separated" Memories., Pedro Bekinschtein, Brianne A Kent, Charlotte A Oomen, Gregory D Clemenson, Fred H Gage, Lisa M Saksida, Timothy J Bussey

Brain and Mind Institute Researchers' Publications

Successful memory involves not only remembering information over time, but also keeping memories distinct and less confusable. The computational process for making representations for similar input patterns more distinct from each other has been referred to as "pattern separation." In this work, we developed a set of behavioral conditions that allowed us to manipulate the load for pattern separation at different stages of memory. Thus, we provide experimental evidence that a brain-derived neurotrophic factor (BDNF)-dependent pattern separation process occurs during the encoding/storage/consolidation, but not the retrieval stage of memory processing. We also found that a spontaneous increase in BDNF in …

Decentering Anthropocentrisms: A Functional Approach To Animal Minds, Matthew C. Altman

Between the Species

Anthropocentric biases manifest themselves in two different ways in research on animal cognition. Some researchers claim that only humans have the capacity for reasoning, beliefs, and interests; and others attribute mental concepts to nonhuman animals on the basis of behavioral evidence, and they conceive of animal cognition in more or less human terms. Both approaches overlook the fact that language-use deeply informs mental states, such that comparing human mental states to the mental states of nonlinguistic animals is misguided. In order to avoid both pitfalls -- assuming that animals have mental lives just like we do, or assuming that they …

Communication And Common Interest, Peter Godfrey-Smith, Manolo Martínez

Publications and Research

Explaining the maintenance of communicative behavior in the face of incentives to deceive, conceal information, or exaggerate is an important problem in behavioral biology. When the interests of agents diverge, some form of signal cost is often seen as essential to maintaining honesty. Here, novel computational methods are used to investigate the role of common interest between the sender and receiver of messages in maintaining cost-free informative signaling in a signaling game. Two measures of common interest are defined. These quantify the divergence between sender and receiver in their preference orderings over acts the receiver might perform in each state …

Metergoline, The Basolateral Amygdala And The Ventral Pallidum: Implications For Panic Disorder, Douglas Ryan Schuweiler

Theses and Dissertations

Panic disorder (PD) is a common mental illness characterized by recurring spontaneous panic attacks. Scientific investigation into PD has been accelerated by the development of rat models of PD. These models can be validated by responses to intravenous sodium lactate (NaLac), including tachycardia, that are similar to PD patient responses. Previous work on established PD models has suggested that antagonism of serotonin (5-HT) receptors in the basolateral amygdala (BLA) may be sufficient to model PD. To test this hypothesis metergoline (MET), a 5-HT receptor antagonist, or vehicle was microinjected into the BLA of anesthetized rats. Following the microinjection, NaLac or …

Differences In Attitudes Towards People With Disabilities: Examining The Effects Of The Presence Of An Assistance Dog, Jennifer A. Coleman

Theses and Dissertations

Individuals with disabilities face various types of social stigma. Research suggests that the presence of an assistance dog leads to an increase in social interactions. The purpose of this study was to determine whether people’s attitudes toward individuals with disabilities differ when pairing that person with an assistance dog. Undergraduate students (N= 244) were randomly assigned to view an individual with a disability either alone or with an assistance dog. Participants rated their attitudes toward the individual, completed a newly developed Implicit Association Test, and answered behavioral intention questions. Results of a hierarchical multiple regression analysis indicated that individuals with …

Using The Massachusetts Youth Screening Instrument–Version 2 On A Community Sample Of African American And Latino/A Juvenile Offenders To Identify Mental Health And Substance Abuse Treatment Needs, Kendell Coker, Jamie Wernsman, Uduakobong N. Ikpe, Jeannie S. Brooks, Lynn Bushell, Barbara Kahn

Psychology Faculty Publications

The Massachusetts Youth Screening Instrument-Version 2 (MAYSI-2) is a brief screening tool used to identify youth in the juvenile justice system that are at-risk for mental health related difficulties. The MAYSI-2 was administered to 5,205 African American and Latino/a youth throughout Chicago, Illinois who were on probation and residing in the community. This study investigated differences (i.e., legal status, gender, age, race/ethnicity) in reporting of mental health symptoms and substance use on the MAYSI-2. Females scored above the clinical cutoffs more frequently than males and there were few differences found between diverted and adjudicated youth. Age comparisons revealed mixed results. …

Discrimination Of Familiar Human Faces In Dogs (Canis Familiaris), Ludwig Huber, Anaïs Racca, Billy Scaf, Zsófia Virányi, Friederike Range

Recognition Collection

Faces are an important visual category for many taxa, and the human face is no exception to this. Because faces differ in subtle ways and possess many idiosyncratic features, they provide a rich source of perceptual cues. A fair amount of those cues are learned through social interactions and are used for future identification of individual humans. These effects of individual experience can be studied particularly well in hetero-specific face perception. Domestic dogs represent a perfect model in this respect, due to their proved ability to extract important information from the human face in socio-communicative interactions. There is also …