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The Effect Of Habituation And Changes In Cognition On Anxious Children's Performance On The Wisc-Iv, Franziska Noack Jan 2014

The Effect Of Habituation And Changes In Cognition On Anxious Children's Performance On The Wisc-Iv, Franziska Noack

LSU Master's Theses

Researchers have shown that children with anxiety disorders perform worse on intelligence tests than children with no diagnosable disorders. At this point, two theories have been put forth to describe the direction of this relationship: anxiety results in lowered test performance, and underlying cognitive deficits result in the development of anxiety. Lowered test performance as a result of anxiety may either be due to attention-deficits due to state anxiety or anxiety-elicited difficulties with long-term retention and learning. The purpose of this study was to further examine the first theory: that clinical levels of anxiety can hamper intelligence test performance in …


Goal-Subgoal Conflict As The Core Feature Of Delay Of Gratification, Violet Cheung-Blunden, Jennifer L. Zahm Jan 2014

Goal-Subgoal Conflict As The Core Feature Of Delay Of Gratification, Violet Cheung-Blunden, Jennifer L. Zahm

Archives of Assessment Psychology

While delay of gratification is a well-established individual difference, its assessment is limited by the original delay paradigm, which is only valid in the age range of four to 11 years. If delay of gratification were to be construed as a competence of resolving goal-subgoal conflicts, a specific type of puzzle games, with a feature called ambiguous subgoal ordering, can be used as an alternative assessment tool. While the child version of this type of puzzle, the Dog-Cat-Mouse task (DCM), is available; an adult version, the Dog-Cat-Mouse-Rabbit task (DCMR), had to be developed. Two studies were conducted to establish the …


Security Of Attachment To Spouses In Late Life: Concurrent And Prospective Links With Cognitive And Emotional Wellbeing, Robert J. Waldinger, Shiri Cohen, Marc S. Schulz, Judith A. Crowell Jan 2014

Security Of Attachment To Spouses In Late Life: Concurrent And Prospective Links With Cognitive And Emotional Wellbeing, Robert J. Waldinger, Shiri Cohen, Marc S. Schulz, Judith A. Crowell

Psychology Faculty Research and Scholarship

Social ties are powerful predictors of late-life health and well-being. Although many adults maintain intimate partnerships into late life, little is known about mental models of attachment to spouses and how they influence aging. A total of 81 elderly heterosexual couples (162 individuals) were interviewed to examine the structure of attachment security to their partners; respondents also completed measures of cognition and well-being concurrently and 2.5 years later. Factor analysis revealed a single factor for security of attachment. Higher security was linked concurrently with greater marital satisfaction, fewer depressive symptoms, better mood, and less frequent marital conflicts. Greater security predicted …


Where Does Electronic Aggression Fit?: A Comparison Of Dimensional And Categorical Models Of Adolescent Aggression, Krista R. Mehari Jan 2014

Where Does Electronic Aggression Fit?: A Comparison Of Dimensional And Categorical Models Of Adolescent Aggression, Krista R. Mehari

Theses and Dissertations

Electronic aggression is a rapidly growing focus of research, but it lacks a unifying theoretical framework that is necessary to advance the field. The lack of a theoretical framework has led to inconsistencies in measurement of electronic aggression, making it difficult to draw conclusions across studies. In general, researchers have assumed that electronic aggression constitutes a new form of aggression, a counterpart to physical, verbal, and relational aggression, due to unique features surrounding the perpetration of electronic aggression. Furthermore, researchers have treated electronic aggression as a categorical variable based on the assumption that “cyberbullies” constitute a distinct group of adolescents. …


An Evaluation Of The Effectiveness Of The Check-In/Check-Out Intervention For Students Engaging In Relational Aggression And Their Classmates, Emily Patty Corwin Jan 2014

An Evaluation Of The Effectiveness Of The Check-In/Check-Out Intervention For Students Engaging In Relational Aggression And Their Classmates, Emily Patty Corwin

LSU Doctoral Dissertations

The purpose of the current study was to evaluate the effectiveness of the Check-in/Check-out intervention (CICO; Crone, Hawken, & Horner, 2010) when it is applied to children who display relationally aggressive behaviors. Previous research indicates that universal, school-wide, interventions are generally ineffective in decreasing behaviors associated with relational aggression. It may be that a targeted intervention, such as CICO, could be more effective. Three schools were selected for participation in the current project, and the fifth grade of each of these schools was targeted. One school served as the treatment school, while the other schools served as the delayed-treatment control …


Fixed-Time Schedule Effects On Participant Responding: An Evaluation Of Similar Vs. Dissimilar Schedule Programs Using A Group Design Approach, Jessica Pearl Alvarez Jan 2014

Fixed-Time Schedule Effects On Participant Responding: An Evaluation Of Similar Vs. Dissimilar Schedule Programs Using A Group Design Approach, Jessica Pearl Alvarez

LSU Doctoral Dissertations

We evaluated the effectiveness of fixed-time (FT) schedules of reinforcement at eliminating participant’s responding using a between-subjects group design. Participants experienced one of three conditions; a FT leaner schedule, a FT yoked schedule, or a FT denser schedule using a computerized experimental program. Dependent variables of interest are the total number of responses made during the fixed-time reinforcement phase and the latency until the participant met extinction or exit criteria.


Programming Generalization : The Use Of Sufficient Exemplars Within A Discrete Trial Training Early Intervention Program For Children With Autism Spectrum Disorder, Carolyn Barahona Jan 2014

Programming Generalization : The Use Of Sufficient Exemplars Within A Discrete Trial Training Early Intervention Program For Children With Autism Spectrum Disorder, Carolyn Barahona

LSU Doctoral Dissertations

Discrete Trial Training (DTT), a skill acquisition paradigm using Applied Behavioral Analysis (ABA) principles, is an empirically validated early intervention method for children with ASD. However, one disadvantage of this treatment is its highly structured method that hinders generalization. Since generalization is essential for independence and overall functioning in children with ASD, programming for generalized behavior change is an important treatment component. Training sufficient exemplars is one generalization programming technique that has led to the transfer of skills across several stimulus contexts. Very few scientific investigations have evaluated the use of sufficient exemplars within a DTT format. Experiment 1 evaluated …


Tracing The Maddening Effects Of Abuses Of Authority: Rationalities Gone Violent In Mental Health Services And Universities, Marilyn J. Palmer, Dyann Ross Jan 2014

Tracing The Maddening Effects Of Abuses Of Authority: Rationalities Gone Violent In Mental Health Services And Universities, Marilyn J. Palmer, Dyann Ross

Research outputs 2014 to 2021

Organisations such as mental health systems and universities can be places where violence is part of the business as usual and hence taken-for-granted functionality of the workplaces. The paper challenges dominant perceptions of who is mad and what is dangerous to unsettle the largely unquestioned legitimacy of indirect and mainly, but not always, non-coercive forms of organisational power. To enable this analysis the research and language of domestic violence is presented to help anchor the nature of organisational violence so that it doesn’t get ignored or deferred as non-problematic, as something that just happens somehow separate from peoples’ actions or …


Hierarchical Graphical Bayesian Models In Psychology, Guillermo Campitelli, Guillermo Macbeth Jan 2014

Hierarchical Graphical Bayesian Models In Psychology, Guillermo Campitelli, Guillermo Macbeth

Research outputs 2014 to 2021

The improvement of graphical methods in psychological research can promote their use and a better comprehension of their expressive power. The application of hierarchical Bayesian graphical models has recently become more frequent in psychological research. The aim of this contribution is to introduce suggestions for the improvement of hierarchical Bayesian graphical models in psychology. This novel set of suggestions stems from the description and comparison between two main approaches concerned with the use of plate notation and distribution pictograms. It is concluded that the combination of relevant aspects of both models might improve the use of powerful hierarchical Bayesian graphical …


The Distinct Contributions Of Affective Distress And Personality To Memory Complaints Made In Older Adulthood, Matthew Robert Merema Jan 2014

The Distinct Contributions Of Affective Distress And Personality To Memory Complaints Made In Older Adulthood, Matthew Robert Merema

Theses: Doctorates and Masters

Whilst a substantial amount of research has investigated the role of affective distress and features of personality in memory complaints made by older adults, little effort has been directed towards understanding their distinct contributions to complaints. Given considerable overlap between affective distress and features of personality, such evidence is necessary to inform theoretical frameworks pertaining to memory complaints and clarify results from other empirical studies examining these concepts. Consequently, the current study examined symptoms of depression and anxiety as predictors of memory complaints within the context of features of personality and other relevant contextual variables (i.e., age, gender, education, premorbid …


An Evaluation Of The Penn Resiliency Program For Disruptive Preadolescents In An Elementary School Setting, Mildred Howard Jan 2014

An Evaluation Of The Penn Resiliency Program For Disruptive Preadolescents In An Elementary School Setting, Mildred Howard

Doctoral Dissertations and Projects

The primary purpose of this study was to evaluate the effectiveness of the Penn Resiliency Program in decreasing disruptive behavior, modifying negative automatic thoughts and improving academic achievement. Forty-eight students from two Title I schools in Georgia participated in this study. The Behavior Assessment Scale for Children, Second Edition, Progress Monitor, The Children's Automatic Thoughts Scale and report card grades were used to evaluate program effectiveness. Research results suggest the program effectively reduced negative automatic thoughts and improved academic performance.


The Appeal Of Narrative In Research, Colette Daiute Jan 2014

The Appeal Of Narrative In Research, Colette Daiute

Publications and Research

"I saw the bird flattened on the ground outside my door . One of the kindergarten child walked toward me slowly, crying. That's when I knew it was time to act."

The very brief narrative above occurs amid myriad spheres of social relations. These relations are not all apparent, but understanding narrative meaning requires understanding narrating as an interactive process. As researchers we enhance our Methods if we know how to read narratives as complex social processes. This openi11g narrative expresses a sequence of two past events.1 The narrative involves action ("walked," "act") and consciousness ("saw," "crying," "knew"). From the …


Proceedings Of The 1st Annual Cuny Games Festival, Robert O. Duncan, Joe Bisz, Francesco Crocco, Carlos Hernandez, Kathleen Offenholley, Leah Potter, Maura A. Smale, Cuny Games Network Jan 2014

Proceedings Of The 1st Annual Cuny Games Festival, Robert O. Duncan, Joe Bisz, Francesco Crocco, Carlos Hernandez, Kathleen Offenholley, Leah Potter, Maura A. Smale, Cuny Games Network

Publications and Research

Proceedings of the CUNY Games Conference, held from January 17-18, 2014, at the CUNY Graduate Center and Borough of Manhattan Community College.

Topics in Game Design - Teaching with Virtual and Augmented Realities - Writing with Games - Breaking the Magic Circle: Games & Real Life - Interactive Game Design (What's Your Game Plan? - Designing Ethical Games - Games and Gender - Gaming English Language and Literature - Game, Narrative, Literacy - Teaching with Games - Games, Storytelling, and Narrative - Games and STEM - Learning by Design - Students as Game Designers - Experiencing Reality in Popular Games …


The Effects Of Nesting Environment On Neonatal Hypoxic-Ischemic Injury, Laura Grace Rollins Dec 2013

The Effects Of Nesting Environment On Neonatal Hypoxic-Ischemic Injury, Laura Grace Rollins

Graduate Masters Theses

Term neonates with hypoxic-ischemic (HI) injury are at risk for devastating neurological sequelae. The objective of this study is to determine if altering the early environment for maternal care-taking impacts the immediate and long-term sequelae of HI offspring. The Rice-Vannucci model was used to induce HI in postnatal day (PND) 7 Long-Evans pups. Litters were assigned to a closed nest (CN) or normal standard housing (SH) condition. Neurobehavioral development, cognitive ability, and stress response were assessed to establish any benefits of the CN condition. Finally, postmortem brain tissue was analyzed for morphometric markers of injury.


Beyond Perceptual Expertise: Revisiting The Neural Substrates Of Expert Object Recognition, Assaf Harel, Dwight J. Kravitz, Chris I. Baker Dec 2013

Beyond Perceptual Expertise: Revisiting The Neural Substrates Of Expert Object Recognition, Assaf Harel, Dwight J. Kravitz, Chris I. Baker

Psychology Faculty Publications

Real-world expertise provides a valuable opportunity to understand how experience shapes human behavior and neural function. In the visual domain, the study of expert object recognition, such as in car enthusiasts or bird watchers, has produced a large, growing, and often-controversial literature. Here, we synthesize this literature, focusing primarily on results from functional brain imaging, and propose an interactive framework that incorporates the impact of high-level factors, such as attention and conceptual knowledge, in supporting expertise. This framework contrasts with the perceptual view of object expertise that has concentrated largely on stimulus-driven processing in visual cortex. One prominent version of …


Private Flashbulb Memories: The Case Of Coming Out Memories, Gabrielle Weber Dec 2013

Private Flashbulb Memories: The Case Of Coming Out Memories, Gabrielle Weber

Undergraduate Honors Thesis Collection

Participants (N = 83) from Butler University and communities in Indianapolis, IN answered a three part questionnaire regarding their experience revealing their homosexual identity to their parents that included: a narrative, a set of probe questions, and a short demographic section. The narrative and probed recall data were scored in a similar fashion to flashbulb memory narratives with canonical features. The memory of revealing homosexuality to parents displayed flashbulb-like qualities. We found that those most confident in their probed recall answers were those with moderate arousal and few recounts. Also, those reporting moderate affect and fewer recounts had better memory …


The Effects Of Chronic Simvastatin Treatment On The Expression Of Behavioral Symptoms In A Transgenic Mouse Model Of Huntington’S Disease, Ashley Whitmarsh Dec 2013

The Effects Of Chronic Simvastatin Treatment On The Expression Of Behavioral Symptoms In A Transgenic Mouse Model Of Huntington’S Disease, Ashley Whitmarsh

LSU New Orleans Theses and Dissertations

Huntington’s disease (HD) is a heritable, neurodegenerative disorder characterized by motor, cognitive, and psychiatric disturbances. An unstable CAG expansion within the gene normally encoding for the Huntingtin protein is responsible. The expanded mutant form of Huntingtin and the putative protein co-factor Rhes interact and cause cell death within the striatum. We hypothesized chronic treatment with simvastatin, a cholesterol lowering drug, would disrupt the biosynthetical pathway which gives both Rhes and its target cells binding sites and render Rhes inactive. Healthy and HD mice were treated with simvastatin or a vehicle. Animals’ motor behavior was assessed with three separate tests over …


Coupling Of The Hpa And Hpg Axes, Andrew Dismukes Dec 2013

Coupling Of The Hpa And Hpg Axes, Andrew Dismukes

LSU New Orleans Theses and Dissertations

The Hypothalamic-Pituitary-Adrenal (HPA) and –Gonadal (HPG) axes have been considered mutually inhibitory; however, emerging evidence supports the proposition that this might not necessarily be the case. This idea is termed “coupling,” in which the HPA-HPG axis are mutually activated or deactivated. Coupling is examined across three data sets with different time-courses of stress exposure, and results demonstrate HPA-HPG co-activation occurs. Furthermore, stress exposure influences this relationship. The discussion shows how it is physiologically possible to have positive coupling or co-activation between these axes according to complex regulatory feedback systems and overlapping neural structures. Findings are interpreted developmentally, because adolescence may …


Hostile Attributional Bias In Aggression And Anxiety: The Role Of Perceived Provocateur Motivation, Melissa M. Kunimatsu Dec 2013

Hostile Attributional Bias In Aggression And Anxiety: The Role Of Perceived Provocateur Motivation, Melissa M. Kunimatsu

LSU New Orleans Theses and Dissertations

Although internalizing and externalizing problems are often considered in isolation from one another, the frequently co-occur in individuals leading to unique behavior profiles. The current study examined the associations between the forms, functions, and subtypes of aggression, anxiety, hostile attributional bias (HAB), and perceived (proactive or reactive) provocateur motivation in a sample of youth (mean age = 13.84 years, 51% male, 37.5% Caucasian). Results indicated that only reactive relational aggression significantly predicted anxiety, while relational and reactive aggression did not. HAB was not significantly associated with either anxiety or any type of aggression. Perceived proactive provocateur motivation was significantly associated …


A Multi-Gene By Environment Perspective Of Adhd Symptomatology In Young Children, Amber L. Allison Dec 2013

A Multi-Gene By Environment Perspective Of Adhd Symptomatology In Young Children, Amber L. Allison

LSU New Orleans Theses and Dissertations

Attention deficit hyperactivity disorder (ADHD) is a heritable disorder, which has detrimental effects on childhood development and is associated with maladaptive functioning in adulthood. Despite this, we are far from an understanding of the etiology and possible trajectories of ADHD, possibly due to investigations focusing on the contribution of single genes. In fact, single genes are likely not influential enough to alter behavior, but the additive effect of many genes may predispose an individual toward certain behaviors. Further, environmental input can activate or suppress genetic expression, thereby leading to vast individual differences in both normative behavior and psychopathological illness, including …


Brief Monocular Deprivation As An Assay Of Short-Term Visual Sensory Plasticity In Schizophrenia - "The Binocular Effect", John J. Foxe, Sheralyn Yeap, Victoria M. Leavitt Dec 2013

Brief Monocular Deprivation As An Assay Of Short-Term Visual Sensory Plasticity In Schizophrenia - "The Binocular Effect", John J. Foxe, Sheralyn Yeap, Victoria M. Leavitt

Publications and Research

Background: Visual sensory processing deficits are consistently observed in schizophrenia, with clear amplitude reduction of the visual evoked potential (VEP) during the initial 50-150 of processing. Similar deficits are seen in unaffected first-degree relatives and drug-naïve first-episode patients, pointing to these deficits as potential endophenotypic markers. Schizophrenia is also associated with deficits in neural plasticity, implicating dysfunction of both glutamatergic and GABAergic systems. Here, we sought to understand the intersection of these two domains, asking whether short-term plasticity during early visual processing is specifically affected in schizophrenia.

Methods: Brief periods of monocular deprivation (MD) induce relatively rapid changes …


Tattoo Stigma And Job Discrimination, Phil Drazewski Dec 2013

Tattoo Stigma And Job Discrimination, Phil Drazewski

Theses and Dissertations

Recent research (Madera & Hebl, 2011) has found that visible stigmas can lead to discrimination against stigmatized individuals in the form of lower job applicant ratings. Tattooed individuals may be one group that faces such discrimination. People with tattoos are perceived less positively than non-tattooed people (Martin & Dula, 2010; Resenhoeft, Villa, & Wiseman, 2008), which may be the result of a tattoo stigma. Pryor & Reeder (2011) suggested that one hallmark of stigmas is that they evoke implicit negative attitudes. In a pilot study, participants implicitly and explicitly evaluated tattooed and non-tattooed individuals, and a tattoo stigma was supported. …


Diffusion Tensor Imaging In Hiv And Hepatitis C Coinfection, Jodi Michelle Heaps Dec 2013

Diffusion Tensor Imaging In Hiv And Hepatitis C Coinfection, Jodi Michelle Heaps

Dissertations

Previous studies have demonstrated that infection with both human immune deficiency virus (HIV) and hepatitis C (HCV) is associated with impaired cognitive function. It is unclear whether co-infection is associated with neuroimaging markers of brain dysfunction. The purpose of the present study was to compare HIV+ individuals, HIV/HCV+ individuals, and seronegative controls using diffusion tensor imaging (DTI) to assess the microstructural integrity of white matter tissue. Methods: Twenty-five HIV+ patients, 25 HIV/HCV+ patients, and 25 seronegative controls matched for age were included in the study. All participants completed an MRI session, neuropsychological testing, and an evaluation of clinical variables including …


Comparison Of Psychogenic Movement Disorder Patients With Non-Epileptic Seizures And Other Hyperkinetic Motor Manifestations: An Integrated Model Of Psychosocial And Neuropsychological Functioning, Bonnie Michelle Scott Dec 2013

Comparison Of Psychogenic Movement Disorder Patients With Non-Epileptic Seizures And Other Hyperkinetic Motor Manifestations: An Integrated Model Of Psychosocial And Neuropsychological Functioning, Bonnie Michelle Scott

Psychology and Counseling Theses

Psychogenic movement disorders (PMDs) represent a complex and severe form of psychopathology, which even after a century of research remains poorly understood. As previous investigations have neglected to differentiate symptom phenotypes and have approached assessment from the perspective of cognitive dysfunction apparent in PMD patient's neurological counterparts, the current study aimed to examine the neurocognitive performance and psychological profiles of PMD patients with hyperkinetic motor manifestations guided by a theoretical lens of frontal lobe pathology and informed by previous neuroimaging studies with this patient population. Subsequent to diagnostic confirmation of their condition by means of video-electroencephalographic monitoring or adherence to …


The Implication Of Patient-Based Interventions Leading To A More Effective Treatment Of Anticipatory Nausea & Vomiting In Cancer Patients, Katelyn Delaney Dec 2013

The Implication Of Patient-Based Interventions Leading To A More Effective Treatment Of Anticipatory Nausea & Vomiting In Cancer Patients, Katelyn Delaney

Honors Theses

In the last thirty years, greater attention has been drawn to the aggressive methods of cancer treatment and the aversive conditioned symptoms they come to elicit. Anticipatory nausea and vomiting is one such aversive conditioned side effect and is significantly prevalent in cancer patients who undergo treatments like chemotherapy. In response to the ineffectiveness of pharmacological interventions to control these symptoms, behavioral intervention methods have grown as a topic of research. The implications of these behavioral interventions (including cognitive/attentional distraction, meditation and systematic desensitization) have proven effective in the treatment of the anticipatory nausea and vomiting and reducing patient anxiety. …


Gay, Straight, Or Slightly Bent? The Interaction Of Leader Sexual Orientation And Gender On Leadership Evaluations, Fred George Macoukji Dec 2013

Gay, Straight, Or Slightly Bent? The Interaction Of Leader Sexual Orientation And Gender On Leadership Evaluations, Fred George Macoukji

USF Tampa Graduate Theses and Dissertations

Abstract

Existing research has shown that gender stereotypes regarding characteristics of men and women influence others' perceptions of their fit with organizational roles, including leadership roles (cf. Eagly & Karau, 2002). However, little research has examined stereotypes regarding other demographic characteristics (e.g., race, sexual orientation) and how they may interact with gender stereotypes to influence leadership evaluations. The current study examined whether leader gender and sexual orientation interact to influence subordinates' evaluations of leader effectiveness, likability, and boss desirability using an experimental design. In addition to examining whether leader gender and sexual orientation interacted to predict leader evaluations, the present …


Work Stress Reactivity And Health Outcomes: A Study Of Nurses, Laurie Marie Jacobs Dec 2013

Work Stress Reactivity And Health Outcomes: A Study Of Nurses, Laurie Marie Jacobs

Dissertations and Theses

Negative events encountered in daily life influence individual well-being. Individuals vary in their reactivity to these events, the extent to which they are behaviorally, physiologically, and psychologically influenced by them (Almeida, 2005; Neupert, Almeida, & Charles, 2007). Reactivity to events in the form of changes in health behavior could represent either an attempt at coping (Cooper, Frone, Russell, & Mudar, 1995) or a stressor-related failure of self-control (Muraven & Baumeister, 2000). Such changes in behavior could have later effects on health.

Although a great deal of attention has been paid to both the immediate and long-term effects of stressors on …


Maternal Monitoring And Maternal Psychological Well-Being: Important Components In Treating Conduct Disorder, Benjamin Rosen Dec 2013

Maternal Monitoring And Maternal Psychological Well-Being: Important Components In Treating Conduct Disorder, Benjamin Rosen

Theses and Dissertations

Conduct disorder is characterized by behaviors that take a large toll on the individuals, families, and communities afflicted. Thus, improving treatment effectiveness should be a high priority. Currently, common intervention programs do not address parental depression, even though it has been linked to adolescent conduct disorder behaviors in some studies. The current study assessed whether the relation between maternal depression and adolescent conduct disorder behaviors is mediated by another factor which has been linked to conduct disorder behaviors, maternal monitoring. Results did not support the hypothesized mediated association, but did show significant individual associations for both maternal depression and maternal …


Environmental- And Ethanol-Induced Effects On Reference And Short-Term Memory In The Rat, Kimberly Ramos Dec 2013

Environmental- And Ethanol-Induced Effects On Reference And Short-Term Memory In The Rat, Kimberly Ramos

Seton Hall University Dissertations and Theses (ETDs)

Environmental enrichment (EE) is a combination of complex physical and social stimulation beyond that which would be received in standard or isolated laboratory housing. Continuous enrichment paradigms have been shown, among other influences, to increase neurogenesis and dendritic branching, and enhance learning and memory. Recently, the preventative effects of enrichment have been considered, specifically relating to drugs of abuse (Solinas, Thiret, Chauvet, & Jaber 2010; Stairs & Bardo 2009). This series of studies examined the effects of daily EE on reference memory and short-term memory, as assessed in the radial arm water maze (RAWM) and Morris water maze (MWM). Sprague-Dawley …


Repeated Asenapine Treatment Produces A Sensitization Effect In Two Preclinical Tests Of Antipsychotic Activity, Rongyin Qin, Yingzhu Chen, Ming Li Dec 2013

Repeated Asenapine Treatment Produces A Sensitization Effect In Two Preclinical Tests Of Antipsychotic Activity, Rongyin Qin, Yingzhu Chen, Ming Li

Department of Psychology: Faculty Publications

Among several commonly used atypical antipsychotic drugs, olanzapine and risperidone cause a sensitization effect in the conditioned avoidance response (CAR) and phencyclidine (PCP)- induced hyperlocomotion paradigms – two well established animal tests of antipsychotic drugs, whereas clozapine causes a tolerance effect. Asenapine is a novel antipsychotic drug recently approved for the treatment of schizophrenia and manic disorders. It shares several receptor binding sites and behavioral features with other atypical antipsychotic drugs. However, it is not clear what type of repeated effect (sensitization or tolerance) asenapine would induce, and whether such an effect is transferrable to other atypicals. In this study, …