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The Reversal Effects Of Curcumin, An Herbal Remedy, On The Impairments Induced By Vmat-2 Inhibitor Tetrabenazine, Emily Qian, Samantha E. Yohn May 2014

The Reversal Effects Of Curcumin, An Herbal Remedy, On The Impairments Induced By Vmat-2 Inhibitor Tetrabenazine, Emily Qian, Samantha E. Yohn

Honors Scholar Theses

Substantial evidence has shown that dopamine (DA), particularly in the nucleus accumbens (NAc), is involved in behavioral activation and effort-related processes, such as overcoming work related response costs. Interference with accumbens DA transmission through administration of the vesicular monoamine transportor-2 (VMAT-2) inhibitor tetrabenazine (TBZ) produces an alteration of response allocation in the concurrent FR5/chow choice procedure, biasing animals toward the lower effort alternative. It has been suggested that these drug-induced shifts in effort-related choice behavior seen in rodents are analogous to symptoms such as psychomotor retardation, anergia, and fatigue, which can be observed in people with depression and other related …

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Evolutionary Pressures On Primate Intertemporal Choice, Jeffrey R. Stevens May 2014

Evolutionary Pressures On Primate Intertemporal Choice, Jeffrey R. Stevens

Department of Psychology: Faculty Publications

From finding food to choosing mates, animals must make intertemporal choices that involve fitness benefits available at different times. Species vary dramatically in their willingness to wait for delayed rewards. Why does this variation across species exist? An adaptive approach to intertemporal choice suggests that time preferences should reflect the temporal problems faced in a species' environment. Here, I use phylogenetic regression to test whether allometric factors (relating to body size), relative brain size, and social group size predict how long 13 primate species will wait in laboratory intertemporal choice tasks. Controlling for phylogeny, a composite allometric factor that includes …

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Antioxidant Gene Therapy Against Neuronal Cell Death, Juliana Navarro-Yepes, Laura Zavala-Flores, Anandhan Annadurai, Fang Wang, Maciej Skotak, Namas Chandra, Ming Li, Aglaia Pappa, Daniel Martinez-Fong, Luz Maria Del Razo, Betzabet Quintanilla-Vega, Rodrigo Franco May 2014

Antioxidant Gene Therapy Against Neuronal Cell Death, Juliana Navarro-Yepes, Laura Zavala-Flores, Anandhan Annadurai, Fang Wang, Maciej Skotak, Namas Chandra, Ming Li, Aglaia Pappa, Daniel Martinez-Fong, Luz Maria Del Razo, Betzabet Quintanilla-Vega, Rodrigo Franco

Department of Psychology: Faculty Publications

Oxidative stress is a common hallmark of neuronal cell death associated with neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, as well as brain stroke/ischemia and traumatic brain injury. Increased accumulation of reactive species of both oxygen (ROS) and nitrogen (RNS) has been implicated inmitochondrial dysfunction, energy impairment, alterations in metal homeostasis and accumulation of aggregated proteins observed in neurodegenerative disorders, which lead to the activation/modulation of cell death mechanisms that include apoptotic, necrotic and autophagic pathways. Thus, the design of novel antioxidant strategies to selectively target oxidative stress and redox imbalance might represent important therapeutic approaches against neurological disorders. …

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Negative Experiences In Physical Education Class And Avoidance Of Exercise, Daphne Brown May 2014

Negative Experiences In Physical Education Class And Avoidance Of Exercise, Daphne Brown

Master's Theses or Doctor of Nursing Practice

One of our nation’s growing concerns is obesity and the effect it has on one’s health and overall quality of life. Determining the underlying causes for an individual’s avoidance of exercise is crucial in battling the obesity crisis. The impact negative feelings involving Physical Education classes taken in adolescence may have on one’s current exercise routines and barriers to current participation in exercise were examined in the current study. Measures of barriers to exercise, self-esteem, current exercise routines and negative experiences involving Physical Education classes were examined. A total of 101 participants completed the measures of barriers to exercise, self-esteem, …

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The Universal Design Paradigm: An Examination Of Real-Time, C-Print, Meaning-For-Meaning Transcription And Individual Differences In Learning, Amanda Boone May 2014

The Universal Design Paradigm: An Examination Of Real-Time, C-Print, Meaning-For-Meaning Transcription And Individual Differences In Learning, Amanda Boone

HIM 1990-2015

The intent of this thesis is to guide further research and discussion of C-Print, meaning-for-meaning transcription and its applications to today’s dynamic classroom settings under a Universal Design Paradigm. Evidence suggests that providing these captions can benefit Deaf and Hard of Hearing populations and also that concise, textual representations of information increase retention for average learners in multimedia settings. Individual differences were considered and low internal control participants did significantly better on exams when material was captioned compared to when it was not. They also tended to outperform high internal control participants on captioned material exams.

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Spatial Schema Transfers To Similar Place: A Case Of Disney Theme Parks, Daphne Kopel May 2014

Spatial Schema Transfers To Similar Place: A Case Of Disney Theme Parks, Daphne Kopel

HIM 1990-2015

The intent of this thesis is to explore whether an existing spatial schema assists with learning a similar environment to the existing schema. Spatially experienced and non-experienced participants of Magic Kingdom Park learned a similar park, Disneyland Park, using a virtual environment. Participants learned the virtual environment either passively or actively. Spatially experienced participants outperformed the non-experienced participants on survey and route knowledge assessments, despite of the training method used in the virtual environment. The results suggest that the existing schema for a similar place transfers to the new environment regardless of passive or active training.

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Attribution Of Blame In A Human-Robot Interaction Scenario, Federico Scholcover May 2014

Attribution Of Blame In A Human-Robot Interaction Scenario, Federico Scholcover

HIM 1990-2015

This thesis worked towards answering the following question: Where, if at all, do the beliefs and behaviors associated with interacting with a nonhuman agent deviate from how we treat a human? This was done by exploring the inter-related fields of Human-Computer and Human-Robot Interaction in the literature review, viewing them through the theoretical lens of anthropomorphism. A study was performed which looked at how 104 participants would attribute blame in a robotic surgery scenario, as detailed in a vignette. A majority of results were statistically non-significant, however, some results emerged which may imply a diffusion of responsibility in human-robot collaboration …

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Brief Prenatal Ethanol Exposure Alters Behavioral Sensitivity To The Kappa Opioid Receptor Agonist (U62,066e) And Antagonist (Nor-Bni) And Reduces Kappa Opioid Receptor Expression, Michael E. Nizhnikov, Ricardo M. Pautassi, Jenna M. Carter, Justine Landin, Elena Varlinskaya, Kelly Bordner, David F. Werner, Norman E. Spear May 2014

Brief Prenatal Ethanol Exposure Alters Behavioral Sensitivity To The Kappa Opioid Receptor Agonist (U62,066e) And Antagonist (Nor-Bni) And Reduces Kappa Opioid Receptor Expression, Michael E. Nizhnikov, Ricardo M. Pautassi, Jenna M. Carter, Justine Landin, Elena Varlinskaya, Kelly Bordner, David F. Werner, Norman E. Spear

Psychology Faculty Scholarship

Approximately 10 to 15% of women consume alcohol (ethanol [EtOH]) during pregnancy in the United States. Even low amounts of EtOH consumption during pregnancy can elicit long-term consequences. Prenatal experience with as few as 3 drinks has been associated with increase problem drinking in adulthood. Such effects are corroborated in rodents; however, the underlying neural adaptations contributing to this effect are not clear. In the current set of experiments, we investigated whether changes in EtOH responding following prenatal EtOH exposure involved kappa opioid receptor activation and expression.Methods
Sprague–Dawley rats were prenatally exposed to low levels of alcohol (1.0 g/kg) during …

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Can Cognitive Priming Influence The Reinforcing Efficacy Of Alcohol Within A Behavioral Economic Framework?, Lauren J. Adams May 2014

Can Cognitive Priming Influence The Reinforcing Efficacy Of Alcohol Within A Behavioral Economic Framework?, Lauren J. Adams

USF Tampa Graduate Theses and Dissertations

A considerable body of research supports the application of behavioral economic principles to study the relative reinforcing efficacy of drug and alcohol use. One self-report measure, the Alcohol Purchase Task, is thought to account for individual differences in the subjective valuation of alcohol consumption. To date, however, behavioral economic approaches have not evaluated the possible influence of memory-based expectations regarding the cognitive and behavioral effects of substance use on their measures. Alcohol expectancy research has found that more positive expectancies about the effects alcohol directly mediate drinking behavior and are associated with a number of alcohol-related outcomes. Given the importance …

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The Effect Of Ovulation As A Male Mating Prime On Drinking And Other Mating Behaviors, Robin Tan May 2014

The Effect Of Ovulation As A Male Mating Prime On Drinking And Other Mating Behaviors, Robin Tan

USF Tampa Graduate Theses and Dissertations

A recent line of research grounded in evolutionary theory has shown that exposure to women's fertility cues affects men's mating cognition and behavior. This area of research has not yet been examined in relation to alcohol. As alcohol has also been shown to facilitate the formation of sexual connections for males, establishing the intersection between these two lines of research seems necessary to understand the impetus behind human behavior. Ninety-eight male participants were primed with either the scent of a fertile woman or the scent of nonfertile woman and then completed measures assessing their level of attraction to pictures of …

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An Animal Model Of The Motivational Symptoms Of Depression: Testing The Antidepressant Desipramine On An Effort-Related Choice Task, Samantha L. Collins May 2014

An Animal Model Of The Motivational Symptoms Of Depression: Testing The Antidepressant Desipramine On An Effort-Related Choice Task, Samantha L. Collins

Honors Scholar Theses

Patients with depression, schizophrenia, and other related disorders often show effort-related motivational symptoms such as anergia, psychomotor slowing, lassitude, and fatigue. Several studies have indicated that dopamine (DA) within the nucleus accumbens (NAc) is involved in the regulation of effort-related behavior. Interference with NAc DA alters response allocation in effort related choice procedures, biasing animals towards the alterative that can be obtained with minimal effort. Previous studies have shown that administration of the vesicular monoamine transporter-2 (VMAT-2) inhibitor tetrabenazine (TBZ) shifts behavior in rats responding on the FR5/chow choice procedure causing a decrease in lever pressing and a compensatory increase …

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Motivations For Targeted School Violence: Examining The Influence Of Social Rejection And Violent Video Games On Aggression, Maxwell R. Christensen May 2014

Motivations For Targeted School Violence: Examining The Influence Of Social Rejection And Violent Video Games On Aggression, Maxwell R. Christensen

Honors Scholar Theses

This Thesis Project investigates putative causes for mass-casualty violence in America’s schools. Both popular and scientific literatures suggest a variety of factors to explain these events, including violence in media such as movies and video games, gun culture, social constructions of masculinity, as well as social isolation, rejection, and disaffection among youth. Whereas such factors are not present in every incidence of mass violence and have yet to be demonstrated as explicitly causal variables, significant evidence points to social rejection in the form of bullying experiences and consumption of violent media such as first-person-shooter video games as representing key driving …

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Role Of The Ventral Tegmental Area And Ventral Tegmental Area Nicotinic Acetylcholine Receptors In The Incentive Amplifying Effect Of Nicotine, Ashley B. Sheppard May 2014

Role Of The Ventral Tegmental Area And Ventral Tegmental Area Nicotinic Acetylcholine Receptors In The Incentive Amplifying Effect Of Nicotine, Ashley B. Sheppard

Electronic Theses and Dissertations

Nicotine has multiple behavioral effects as a result of its action in the central nervous system. Nicotine strengthens the behaviors that lead to nicotine administration (primary reinforcement), and this effect of nicotine depends on mesotelencephalic systems of the brain that are critical to goal directed behavior, reward, and reinforcement. Nicotine also serves as a ‘reinforcement enhancer’ – drug administration enhances behaviors that lead to other drug and nondrug reinforcers. Although the reinforcement enhancing effects of nicotine may promote tobacco use in the face of associated negative health outcomes, the neuroanatomical systems that mediate this effect of nicotine have never been …

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Does Nicotine Alter What Is Learned About Non-Drug Incentives?, Tarra L. Baker May 2014

Does Nicotine Alter What Is Learned About Non-Drug Incentives?, Tarra L. Baker

Undergraduate Honors Theses

Nicotine is one of the most addictive drugs known to man, yet it has limited reinforcing effects in humans and non-human animals when it is not self-administered in tobacco products. One hypothesis for these paradoxical effects of nicotine is that the effects of the drug in the brain alter acquisition of incentive learning. The hypothesis for this study is that nicotine will increase the value of cues paired with a reward. To test this hypothesis, 26 Sprague Dawley Male rats were randomly assigned to one of three groups Pre-NIC (the critical experimental group), Post-NIC and SAL. Each group received a …

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Neuromodulation Therapy Mitigates Heart Failure Induced Hippocampal Damage, Timothy P. Diperi May 2014

Neuromodulation Therapy Mitigates Heart Failure Induced Hippocampal Damage, Timothy P. Diperi

Undergraduate Honors Theses

Cardiovascular disease (CVD) is the leading cause of death in the United States. Nearly half of the people diagnosed with heart failure (HF) die within 5 years of diagnosis. Brain abnormalities secondary to CVD have been observed in many discrete regions, including the hippocampus. Nearly 25% of patients with CVD also have major depressive disorder (MDD), and hippocampal dysfunction is a characteristic of both diseases. In this study, the hippocampus and an area of the hippocampal formation, the dentate gyrus (DG), were studied in a canine model of HF. Using this canine HF model previously, we have determined that myocardial …

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Reciprocal Relation Between Psychophysiological Patterns Of Stress Responsivity And Sleep, Miguel A. Velasquez May 2014

Reciprocal Relation Between Psychophysiological Patterns Of Stress Responsivity And Sleep, Miguel A. Velasquez

Senior Honors Theses

Contemporary understanding of the brain indicates that a reciprocal relationship exists between mind and body. Biological functioning adjusts to the consequences of our behavior and our behavior is influenced by our biology. This is the case with the stress responsivity system. The stress hormone cortisol follows a biologically-predetermined daily cycle of secretion (controlled by circadian rhythm) that correlates with expected activity throughout the day, however this cycle can accommodate to different environmental changes that can occur. It has been noticed that individuals who report stress problems also report sleep problems. I hypothesized that sleep quality can predict maladjustments in cortisol’s …

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Contextual Differences In Reinforcement Affect Self-Control In Shr And Wky Subjects, Jonathan C. Rich May 2014

Contextual Differences In Reinforcement Affect Self-Control In Shr And Wky Subjects, Jonathan C. Rich

Undergraduate Honors Capstone Projects

The spontaneously hypertensive rat (SHR) is the outcome of selectively breeding its progenitor the Wistar Kyoto (WKY) for hypertension. In the present experiment, the context of reinforcement was manipulated to determine its effect on impulsivity across the SHR and WKY strains of rat. An additional block of delays was added onto the end of a standard delay discounting procedure to vary the context of reinforcement from one condition (0 sec.) to the next (60 sec.). Results indicate that both SHR and WKY subjects made fewer impulsive decisions when a shorter delay followed the longest delay in the task - although …

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Does The Way Exposure Exercises Are Presented Matter? Comparing Fear Reduction Versus Fear Toleration Models, Ellen J. Bluett May 2014

Does The Way Exposure Exercises Are Presented Matter? Comparing Fear Reduction Versus Fear Toleration Models, Ellen J. Bluett

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Exposure therapy is considered to be a first line treatment for a variety of anxiety disorders as supported by several review studies. However, there is no clear understanding of how it works. The present study examined how framing exposure exercises impacted outcomes in socially anxious individuals. We conducted a brief two-session exposure-based intervention, including experiential exercises from each therapeutic rationale, with homework assigned between sessions. We were specifically interested in the efficacy of four brief skills interventions: (a) fear reduction, (b) psychological flexibility, (c) values rationale, and (d) control for reducing public speaking anxiety from first to second exposure session. …

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Global Malnutrition: Challenges Associated With Current Intervention Strategies And Prevention Initiatives, Duncan Stiller May 2014

Global Malnutrition: Challenges Associated With Current Intervention Strategies And Prevention Initiatives, Duncan Stiller

Senior Honors Projects

Few, if any, tribulations in the field of public health have managed to transcend the epidemiological transition from acute to chronic disease as malnutrition has. Officially, malnutrition is a category of diseases that includes micronutrient deficiency, under-nutrition (calories/protein), as well as excessive nutrition. The World Food Program estimates that 842 million people worldwide do not have access to enough food, approximately 146 million of which are children. The most serious types of hunger are known as Severe Acute Malnutrition (SAM) and Moderate Acute Malnutrition (MAM), with 20 million and 35 million respective cases each year occurring in children less than …

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The Effects Of Maternal Information Transmission On Daughters' Responding To A Voluntary Hyperventilation Challenge, Ashley Arehart Knapp May 2014

The Effects Of Maternal Information Transmission On Daughters' Responding To A Voluntary Hyperventilation Challenge, Ashley Arehart Knapp

Graduate Theses and Dissertations

Contemporary models of panic etiology would benefit from additional tests of how fear of internal cues is acquired. Drawing from literature suggesting parent-to-child verbal information transmission is one pathway by which fear of external stimuli is learned, the current study is designed to address the effects of this pathway on fearful responding to internal cues (i.e., somatic perturbation produced by a voluntary hyperventilation challenge). Specifically, 53 mothers of adolescent females between the ages of 10 and 14 years were randomly assigned to either share negative or positive information regarding their experience with a voluntary hyperventilation challenge prior to their daughters …

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Faces As Ambient Displays: Assessing The Attention-Demanding Characteristics Of Facial Expressions, Brock Bass May 2014

Faces As Ambient Displays: Assessing The Attention-Demanding Characteristics Of Facial Expressions, Brock Bass

All Theses

Ambient displays are used to provide information to users in a non-distracting manner. The purpose of this research was to examine the efficacy of facial expressions as a method of conveying information to users in an unobtrusive way. Facial expression recognition requires very little if any conscious attention from the user, which makes it an excellent candidate for the ambient presentation of information. Specifically, the current study quantified the amount of attention required to decode and recognize various facial expressions. The current study assessed the attention-demanding characteristics of facial expressions using the dual-task experiment paradigm. Results from the experiment suggest …

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The Formation Of Situation Models In Multimedia, Kris Gunawan May 2014

The Formation Of Situation Models In Multimedia, Kris Gunawan

UNLV Theses, Dissertations, Professional Papers, and Capstones

When people read traditional text-based stories, they construct mental representations of the described state of affairs, called situation models, to connect various details of events (e.g., time, space, entity) in memory (Zwaan & Radvansky, 1998). According to the cognitive theory of multimedia learning (Mayer, 2005; 2011), stories presented as pictures and text generate independent channels of mental representations that can work hand-in-hand or separately to acquire and remember the materials presented. This dissertation consisted of two experiments that were used to further explore how the two modalities affect what is being mentally represented in memory. In Experiment 1, participants were …

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School Climate, Absenteeism, And Psychopathology Among Truant Youth, Marisa Charlene Hendron May 2014

School Climate, Absenteeism, And Psychopathology Among Truant Youth, Marisa Charlene Hendron

UNLV Theses, Dissertations, Professional Papers, and Capstones

School refusal behavior has become highly problematic for schools worldwide. Researchers have focused efforts on examining many factors related to absenteeism, including child, parent, family, peer, school, and community variables. Many previous researchers examined absenteeism between groups (i.e. truants vs. nontruants, truants vs. school refusers). The present study investigated percentage of absenteeism in relation to contextual variables in a diverse sample of truants referred to programs designed to improve attendance. First, a model of school climate (Sharing of Resources, Order and Discipline, Parent Involvement, Student Interpersonal Relations, and Student-Teacher Relations) contributing to severity of absenteeism was tested via structural equation …

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The Effect Of Early Life Stress On Methamphetamine Damage In The Striatum, Emily Hensleigh May 2014

The Effect Of Early Life Stress On Methamphetamine Damage In The Striatum, Emily Hensleigh

UNLV Theses, Dissertations, Professional Papers, and Capstones

Methamphetamine (METH) abuse impacts the global economy through costs associated with drug enforcement, emergency room visits, and treatment. Hyperthermia is a leading cause of METH induced emergency room visits and may lead to neural damage. Previous research has demonstrated early life stress, such as childhood abuse, increases the likelihood of developing a substance abuse disorder. However, the effects of early life stress on neuronal damage induced by chronic METH administration are unknown. We aimed to elucidate the effects of early life stress on METH induced dopamine damage in the striatum. Animals were separated three hours per day during the first …

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What's Age Got To Do With It? Examining How The Age Of Stimulus Faces Affects Children's Implicit Racial Bias, Erica Cheree Noles May 2014

What's Age Got To Do With It? Examining How The Age Of Stimulus Faces Affects Children's Implicit Racial Bias, Erica Cheree Noles

UNLV Theses, Dissertations, Professional Papers, and Capstones

Discrepant results regarding the emergence of children's implicit racial bias suggest additional research is needed to understand the developmental timeline of racial bias. Investigations using established explicit racial bias measures and the implicit association task with children demonstrate racial bias in young children (Aboud, 1988; Baron & Banjai, 2006). These findings do not corroborate the only known developmental use of the affective priming task (APT) to measure racial bias, which suggests implicit racial bias does not emerge until adolescence (Degner & Wentura, 2010). Variations in the task demands, the types of stimuli used to represent the construct of race, and …

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Wisc-Iv Profiles In Children With Attention Deficit Hyperactivity Disorder And Comorbid Learning Disabilities, Elyse Parke May 2014

Wisc-Iv Profiles In Children With Attention Deficit Hyperactivity Disorder And Comorbid Learning Disabilities, Elyse Parke

UNLV Theses, Dissertations, Professional Papers, and Capstones

Attention Deficit Hyperactivity Disorder (ADHD) and learning disabilities (LD), including Reading Disorder (RD), Disorder of Written Expression (DWE), and Developmental Coordination Disorder (DCD) all co-occur at high rates. Previous research indicates increased neurocognitive impairment in ADHD with the presence of comorbid diagnoses. However, few direct comparisons between intellectual profiles of children with one or multiple ADHD and LD diagnoses are available, specifically for the Wechsler Intelligence Scale Fourth Edition (WISC-IV), despite its frequent and historical use with this population. Profile analysis may contribute insights into spared and impaired abilities. Therefore, the present study addressed these matters by comparing WISC-IV profiles …

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Choice And Control Of Enrichment For A Rescued And Rehabilitated Atlantic Bottlenose Dolphin (Tursiops Trunactus), Hannah Bahe May 2014

Choice And Control Of Enrichment For A Rescued And Rehabilitated Atlantic Bottlenose Dolphin (Tursiops Trunactus), Hannah Bahe

Honors Theses

Animals living under human care experience stress related to a lack of control over t environment. One way to remedy this is through the use of cognitive enrichment, su choice and control of enrichment. This type of enrichment has been shown to have benefits for animals under human care including increased activity and social interactions. To determine if choice and control was more beneficial than enrichmen alone, a three year old male Atlantic bottlenose dolphin (Tursiops truncatus) was ex to novel enrichment items in two experimental conditions. For the first condition, th animal was given a novel object. During the …

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The Diathesis-Stress Model Of Corruption By The Ruling Ring: Nature, Power, And Exposure In J. R. R. Tolkien’S The Lord Of The Rings, Faith R. Holley Apr 2014

The Diathesis-Stress Model Of Corruption By The Ruling Ring: Nature, Power, And Exposure In J. R. R. Tolkien’S The Lord Of The Rings, Faith R. Holley

Student Scholarship

In J. R. R. Tolkien’s The Lord of the Rings, the One Ring seems to exert power over some characters more than others. Though these differences could seem like an oversight or a lack of continuity, they also offer the opportunity to examine the effects of the differential power of the Ring. If the Ring is addictive, as Tom Shippey claims in The Road to Middle Earth, then it is possible to examine the etiology of addiction to the Ring (126). In this thesis, I present a psychological reading of Tolkien that relies on a modern psychological theory, namely the …

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Openness, Neuroticism, Conscientiousness, And Family Health And Aging Concerns Interact In The Prediction Of Health-Related Internet Searches In A Representative U.S. Sample, Tim Bogg, Phuong T. Vo Apr 2014

Openness, Neuroticism, Conscientiousness, And Family Health And Aging Concerns Interact In The Prediction Of Health-Related Internet Searches In A Representative U.S. Sample, Tim Bogg, Phuong T. Vo

Psychology Faculty Research Publications

Recent estimates suggest 60 % of the U.S. adult population uses the Internet to find health-related information. The goal of the present study was to model health-related Internet searches as a function of an interdependent system of personality adaptation in the context of recent health and aging-related concerns. Assessments of background factors, Big Five personality traits, past-month health and aging-related concerns, and the frequency of past-month health-related Internet searches (via Google, Yahoo, AOL, Bing, or some other search engine) were obtained from a representative U.S. sample (N = 1,015). Controlling for background factors, regression analyses showed more frequent health-related …

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Dissociable Antidepressant-Like And Abuse-Related Effects Of The Noncompetitive Nmda Receptor Antagonists Ketamine And Mk-801 In Rats., Todd Hillhouse Apr 2014

Dissociable Antidepressant-Like And Abuse-Related Effects Of The Noncompetitive Nmda Receptor Antagonists Ketamine And Mk-801 In Rats., Todd Hillhouse

Theses and Dissertations

The noncompetitive NMDA receptor antagonist ketamine produces rapid and sustained antidepressant effects in patients suffering from major depressive disorder. However, abuse liability is a concern. To further evaluate the relationship between antidepressant-like and abuse-related effects of NMDA receptor antagonists, this study evaluated the effects of ketamine, MK-801, and phencyclidine in male Sprague-Dawley rats responding under two procedures that have been used to assess antidepressant-like effects [differential-reinforcement-of-low-rate (DRL) 72 s schedule of food reinforcement] and abuse-related drug effects [intracranial self-stimulation (ICSS)]. Under DRL 72 s, ketamine produced an antidepressant-like effect by increasing reinforcers, decreasing responses, and producing a rightward shift in …

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