Digital Commons Network^™

Asenapine Sensitization From Adolescence To Adulthood And Its Potential Molecular Basis, Qing Shu, Rongyin Qin, Yingzhu Chen, Gang Hu, Ming Li

Department of Psychology: Faculty Publications

Asenapine is a new antipsychotic drug that induces a long-lasting behavioral sensitization in adult rats. The present study investigated the developmental impacts of adolescent asenapine treatment on drug sensitivity and on 3 proteins implicated in the action of antipsychotic drugs (i.e. Brainderived neurotrophic factor (BDNF), dopamine D₂ receptor, and ΔFosB) in adulthood. Male adolescent Sprague-Dawley rats (postnatal days, P 43-48) were first treated with asenapine (0.05, 0.10 or 0.20 mg/kg, sc) and tested in the conditioned avoidance or PCP (2.0 mg/kg, sc)-induced hyperlocomotion tasks for 5 days. After they became adults (∼P 76), asenapine sensitization was assessed in a …

Depressive-Like Behavioral Response Of Adult Male Rhesus Monkeys During Routine Animal Husbandry Procedure, Michael B. Hennessy, Brenda Mccowan, Jing Jiang, John P. Capitanio

Psychology Faculty Publications

Social isolation is a major risk factor for the development of depressive illness; yet, no practical nonhuman primate model is available for studying processes involved in this effect. In a first study, we noted that adult male rhesus monkeys housed individually indoors occasionally exhibited a hunched, depressive-like posture. Therefore, Study 2 investigated the occurrence of a hunched posture by adult males brought from outdoor social groups to indoor individual housing. We also scored two other behaviors—lying on the substrate and day time sleeping—that convey an impression of depression. During the first week of observation following individual housing, 18 of 26 …

Intergeniculate Leaflet Lesions Result In Differential Activation Of Brain Regions Following The Presentation Of Photic Stimuli In Nile Grass Rats, Andrew J. Gall, Lily Yan, Laura Smale, Antonio A. Nunez

Faculty Publications

The intergeniculate leaflet (IGL) plays an important role in the entrainment of circadian rhythms and the mediation of acute behavioral responses to light (i.e., masking). Recently, we reported that IGL lesions in diurnal grass rats result in a reversal in masking responses to light as compared to controls. Here, we used Fos as a marker of neural activation to examine the mechanisms by which the IGL may influence this masking effect of light in grass rats. Specifically, we examined the patterns of Fos activation in retinorecipient areas and in brain regions that receive IGL inputs following 1-h light pulses given …

Speaking Two Languages Enhances An Auditory But Not A Visual Neural Marker Of Cognitive Inhibition, Mercedes Fernandez, Juliana Acosta, Kevin Douglass, Nikita Doshi, Jaime L. Tartar

Faculty Articles

The purpose of the present study was to replicate and extend our original findings of enhanced neural inhibitory control in bilinguals. We compared English monolinguals to Spanish/English bilinguals on a non-linguistic, auditory Go/NoGo task while recording event-related brain potentials. New to this study was the visual Go/NoGo task, which we included to investigate whether enhanced neural inhibition in bilinguals extends from the auditory to the visual modality. Results confirmed our original findings and revealed greater inhibition in bilinguals compared to monolinguals. As predicted, compared to monolinguals, bilinguals showed increased N2 amplitude during the auditory NoGo trials, which required inhibitory control, …

Anthropomorphism, Anthropectomy, And The Null Hypothesis, Kristin Andrews, Brian Huss

Experimentation Collection

We examine the claim that the methodology of psychology leads to a bias in animal cognition research against attributing ‘‘anthropomorphic’’ properties to animals (Sober in Thinking with animals: new perspectives on anthropomorphism. Columbia University Press, New York, pp 85–99, 2005; de Waal in Philos Top 27:225–280, 1999). This charge is examined in light of a debate on the role of folk psychology between primatologists who emphasize similarities between humans and other apes, and those who emphasize differences. Weargue that while in practice there is sometimes bias, either in the formulation of the null hypothesis or in the preference of Type-II …

Laterality Influences Cognitive Performance In Rainbowfish Melanotaenia Duboulayi, Anne-Laurence Bibost, Culum Brown

Sentience Collection

Cerebral lateralization has been suggested to convey a selective advantage to individuals by enhancing their cognitive abilities. Few, however, have explicitly compared the cognitive ability of animals with strongly contrasting laterality. Here, we examined the influence of laterality on learning performance in the crimson spotted rainbowfish, Melanotaenia duboulayi, using a classical conditioning paradigm. We also compared the learning ability of wild caught and captive-reared fish to examine the influence of rearing environment on cognitive performance. Laterality was established by observing which eye fish preferred to use while viewing their mirror image. Subjects were then conditioned to associate the appearance of …

A Comparison Of Spatial Learning And Memory Capabilities In Intertidal Gobies, Gemma E. White, Culum Brown

Sentience Collection

For the majority of animals, the ability to orient in familiar locations is a fundamental part of life, and spatial memory allows individuals to remember key locations such as food patches, shelter, mating sites or areas regularly occupied by predators. This study determined if gobies collected from rocky platforms and sandy beaches differ in their ability to learn and memorise the locations of tide pools in a simulated rocky intertidal zone. Intertidal rock pool gobies show acute homing abilities and, therefore, should be expected to display superior learning and memory capabilities. In contrast, it is unlikely that natural selection would …

Socialising Piglets In Lactation Positively Affects Their Post-Weaning Behaviour, Talia Morgan, John Pluske, David Miller, Teresa Collins, Anne L. Barnes, Françoise Wemelsfelder, Patricia A. Fleming

Sentience Collection

Although commercial farrowing sheds keep individual litters separated, previous studies have suggested that housing systems that allow socialisation of piglets pre-weaning can reduce aggression after weaning. This study tested whether pigs socialised with non-littermates pre-weaning would show less aggression during mixing at weaning (when piglets are taken from their sows and mixed in group housing), and whether socialisation influenced the time budgets or behavioural expression of piglets at weaning. In total, 353 piglets were followed from birth through to one week after weaning. Piglets from 24 sows were allowed to socialise in groups of four litters (‘socialised’ treatment group) from …

Behaviour Of Horses In A Judgment Bias Test Associated With Positive Or Negative Reinforcement, Sabrina Briefer Freymond, Elodie F. Briefer, Anja Zollinger, Yveline Gindrat-Von Allmen, Christa Wyss, Iris Bachmann

Ethology Collection

Moods can influence our judgment of ambiguous stimuli as positive or negative. Measuring judgment bias in animals is a promising method to objectively assess their emotional states. Our study aimed to develop a cognitive bias test in horses, in order to assess the effect of training using positive reinforcement (PR) or negative reinforcement (NR) on their emotional states. We trained 12 mares to discriminate between a rewarded and a non-rewarded location situated on each side of a paddock. The mares were then trained during five days to perform several exercises using PR (n = 6) for one group, and NR …

Emotional Engagements Predict And Enhance Social Cognition In Young Chimpanzees, Kim A. Bard, Roger Bakeman, Sarah T. Boysen, David A. Leavens

Sentience Collection

Social cognition in infancy is evident in coordinated triadic engagements, that is, infants attending jointly with social partners and objects. Current evolutionary theories of primate social cognition tend to highlight species differences in cognition based on human-unique cooperative motives. We consider a developmental model in which engagement experiences produce differential outcomes. We conducted a 10-year-long study in which two groups of laboratory-raised chimpanzee infants were given quantifiably different engagement experiences. Joint attention, cooperativeness, affect, and different levels of cognition were measured in 5- to 12-month-old chimpanzees, and compared to outcomes derived from a normative human database. We found that joint …

Sharp Emergence Of Feature-Selective Sustained Activity Along The Dorsal Visual Pathway., Diego Mendoza-Halliday, Santiago Torres, Julio C Martinez-Trujillo

Brain and Mind Institute Researchers' Publications

Sustained activity encoding visual working memory representations has been observed in several cortical areas of primates. Where along the visual pathways this activity emerges remains unknown. Here we show in macaques that sustained spiking activity encoding memorized visual motion directions is absent in direction-selective neurons in early visual area middle temporal (MT). However, it is robustly present immediately downstream, in multimodal association area medial superior temporal (MST), as well as and in the lateral prefrontal cortex (LPFC). This sharp emergence of sustained activity along the dorsal visual pathway suggests a functional boundary between early visual areas, which encode sensory inputs, …

Oh, Behave! Behavior As An Interaction Between Genes & The Environment, Emily G. Weigel, Michael Denieu, Andrew J. Gall

Faculty Publications

This lesson is designed to teach students that behavior is a trait shaped by both genes and the environment. Students will read a scientific paper, discuss and generate predictions based on the ideas and data therein, and model the relationships between genes, the environment, and behavior. The lesson is targeted to meet the educational goals of undergraduate introductory biology, evolution, and animal behavior courses, but it is also suitable for advanced high school biology students. This lesson meets the criteria for the Next Generation Science Standard HS-LS4, Biological Evolution: Unity and Diversity (NGSS Lead States, 2013).

Shared Neural Circuits: The Connection Between Social And Physical Pain, Laura A. Andrews, Theresa E. Didonato

Modern Psychological Studies

Interpersonal rejection, exclusion, and loss are known to produce painful feelings (Eisenberger, Lieberman, & Williams, 2003), but little is know about the neural network underlying this type of pain. Recent evidence suggests this social pain may have important neural connections with physical pain (Eisenberger et al., 2003). The current literature review explores the connection between social pain and physical pain in neural activity, individual differences (e.g., pain sensitivity), situation appraisal, social support, and pain reducers (e.g., acetaminophen). The review examines the overlapping pain system as an evolutionary adaptation necessary for survival (MacDonald & Leary, 2005). Authentic experiences of social rejection …

Terror Management Theory: A Theoretical Perspective On Orgination, Maintenance, And Research, Robert B. Arrowood, J. Brian Pope

Modern Psychological Studies

Research suggests that humans engage in several worldview defense mechanisms to shield against the terror associated with an awareness of mortality (Greenberg, Pyszczynski, & Solomon, 1986). To mitigate anxiety, people strongly adhere to their cultural worldviews that allow them to boost their self-esteem. This self-esteem fosters a sense of immortality because the world is considered a 'just" place that will not harm someone that is living in adherence to cultural guidelines (Rosenblatt, Greenberg, Solomon, Pyszczynski, & Lyon, 1989). This paper provides a theoretical background for Terror Management Theory including its philosophical origination, the primary tenets of the theory, and the …

Examination Of Psychopathic Traits And Attention Using The Image Based Parity Task, Veronica Claudia Llamas

Loma Linda University Electronic Theses, Dissertations & Projects

Psychopathy has been defined as including deficits in affective, cognitive, and behavioral functioning. Due to the severity of these deficits, several etiological theories have emerged in an attempt to better understand the personality construct. The response modulation hypothesis (RMH; Patterson & Newman, 1993) is a theory growing in popularity among researchers and posits that an inability to reallocate attentional resources to peripheral information moderates the affective and behavioral deficits commonly documented within individuals with psychopathy. Thus, the present study attempted to examine to test the validity of the RMH in a non-incarcerated population. The results somewhat support the theory that …

Effects Of Cigarette Smoking On Neurocognitive Performance In Dementia Patients, Christina Mannino

Loma Linda University Electronic Theses, Dissertations & Projects

Dementia has become a serious problem worldwide due to the rapidly increasing incidence rate and the lack of effective treatments that cure or slow disease progression, and thus. prevention is crucial. Some studies suggests that cigarette smoking may increase the risk of developing dementia, but others suggest that smoking may have a neuroprotective effect. To clarify our understanding of the relationship between cigarette smoking and dementia, this study examined the effects of smoking on multiple cognitive domains via secondary data analysis of a sample consisting of 54% female subjects with an average age of 58±13 years. Measures of executive function, …

Predicting Cognitive Decline In Older Adults, Kimberly M. Baerresen

Loma Linda University Electronic Theses, Dissertations & Projects

The investigator sought to determine which neuropsychological tests are more likely to predict an individual’s cognitive decline (i.e., normal to mild cognitive impairment, mild cognitive impairment to Alzheimer’s disease) two years prior to conversion. A sample of non-decliners (N=109) compared to those who declined (N=24) in cognitive status (i.e., mild cognitive impairment or Alzheimer’s disease) with a mean age of 61.44 (SD=11.29) was examined. Results indicate the Rey-Osterrieth Complex Figure Test, Retention Trial (RCFT Retention; OR=0.93, p=0.005) is a significant predictor of conversion to MCI and the Buschke Delay (OR=0.54, p=0.017) is a significant predictor of conversion to AD. Due …

Changes In Emotion Drive Perceptual Level Shifts: Global Vs. Local Processing, Seda Terzyan

Loma Linda University Electronic Theses, Dissertations & Projects

Different emotional states have been implicated in bringing about specific changes in attention, with positive emotions globalizing attention and negative emotions localizing attention (Fredrickson, 2004). Biases in attentional processes have been associated with the development and maintenance of emotional disorders, anxiety being the most common. Previous studies have shown that anxious individuals present with a bias toward negative information and more readily employ localized attentional processes (Macleod, 2002). This finding demonstrated a link between perceptual levels of attention with higher order conceptual attention, which in turn influences emotional states. Many researchers have explored this relationship, including Fredrickson (2004), who developed …

Effects Of Proton Radiation On Behavior In A Mouse Model Of Alzheimer’S Disease, John A. Bellone

Loma Linda University Electronic Theses, Dissertations & Projects

Astronauts venturing outside Earth’s magnetosphere risk exposure to charged particle radiation that has been shown to cause neurological deficits in rodents via oxidative stress, neuroinflammation, altered neurogenesis, and synaptic changes. Since these responses are similar to those observed in age-related neurodegenerative diseases, we hypothesized that individuals with a propensity toward developing Alzheimer’s disease (AD) would be more adversely affected by such exposure. To test this hypothesis, we exposed young double transgenic APP/PSEN1 mice (a commercially available strain engineered to develop AD-like neuropathology) and their wild-type (non-transgenic) counterparts to low doses of 150 MeV proton particle radiation and assessed the effects …

The Impact Of Technology On Adolescent Identity Development, Christina Frederick, Amy Bradshaw Hoppock, Devin Liskey, Daniel Brown

Publications

This paper explores how technology use in adolescence facilitates adult identity achievement and presents evidence that technological objects, such as smartphones have become adolescent transitional objects. Early and late adolescents were surveyed about technology use and feelings associated with technology. Among older adolescents, anxiety level was related to smart phone use, such that higher anxiety was associated with greater smart phone use. The feelings and behaviors associated with use of the preferred device are consistent with feelings and behaviors associated with use of a transitional object. In contrast, younger adolescents did not appear to use technology as a transitional object. …

De Novo Assembly Of The Common Marmoset Transcriptome From Nextgen Mrna Sequences, Mnirnal D. Maudhoo, Dongren Ren, Julien S. Gradnigo, Robert M. Gibbs, Austin C. Lubker, Etsuko N. Moriyama, Jeffrey French, Robert B. Norgren

Psychology Faculty Publications

Background: Nonhuman primates are important for both biomedical studies and understanding human evolution. Although research in these areas has mostly focused on Old World primates, such as the rhesus macaque, the common marmoset (Callithrix jacchus), a New World primate, offers important advantages in comparison to other primates, such as an accelerated lifespan. To conduct Next Generation expression studies or to study primate evolution, a high quality annotation of the marmoset genome is required. The availability of marmoset transcriptome data from five tissues, including both raw sequences and assembled transcripts, will aid in the annotation of the newly …

Why Primate Models Matter, Kimberley A. Phillips, K. L. Bales, J. P. Capitanio, A. Conley, P. W. Czoty, B. A. 'T Hart, William D. Hopkins, S.L. Hu, L. A. Miller, M. A. Nader, P. W. Nathanielsz, J. Rogers, C. A. Shively, M.L. Voytko

Psychology Faculty Research

Research involving nonhuman primates (NHPs) has played a vital role in many of the medical and scientific advances of the past century. NHPs are used because of their similarity to humans in physiology, neuroanatomy, reproduction, development, cognition, and social complexity – yet it is these very similarities that make the use of NHPs in biomedical research a considered decision. As primate researchers, we feel an obligation and responsibility to present the facts concerning why primates are used in various areas of biomedical research. Recent decisions in the United States, including the phasing out of chimpanzees in research by the National …

Female Mating Adaptations: Salient Features And The Influence Of Fertility Status, Katherine Melton

Modern Psychological Studies

Modern human beings share the adaptive mating strategies of their ancestral predecessors, even though the adaptive environment is a relic of the past. Due to the large parental investment mammalian females must contribute in order to reproduce, women face unique challenges in their quest for reproductive fitness. This review endeavors to address behavioral, strategic, and perceptual shifts in female mating adaptations within the context of the menstrual cycle in order to yield a greater understanding of modern women and the evolutionary basis for behavior.

The Relationship Between Traumagenic Dynamic Responses Towards Childhood Sexual Abuse, Ethnic Identity, Social Support, Trauma Severity, And Attitudes Towards Interpersonal Relationships In Adolescent Females, Nita J. Makhija

Seton Hall University Dissertations and Theses (ETDs)

This study used the theory of traumagenic dynamics (TD) to examine how symptomatology resulting childhood sexual abuse (CSA) are related to the attitudes adolescent females have towards interpersonal relationships. The ultimate goal being that this understanding can inform the creation and implementation of empirically based clinical interventions that specifically target CSA-related symptoms which are associated with the endorsement of unhealthy attitudes towards romantic relationships. In examining this relationship, family support and ethnic identity were examined as protective factors against the endorsement of unhealthy attitudes towards romantic relationships, and trauma severity and the presence of domestic violence in the home were …

Pupil Dilation Dynamics Track Attention To High-Level Information, Olivia E. Kang, Katherine E. Huffer, Thalia P. Wheatley

Dartmouth Scholarship

It has long been thought that the eyes index the inner workings of the mind. Consistent with this intuition, empirical research has demonstrated that pupils dilate as a consequence of attentional effort. Recently, Smallwood et al. (2011) demonstrated that pupil dilations not only provide an index of overall attentional effort, but are time-locked to stimulus changes during attention (but not during mind-wandering). This finding suggests that pupil dilations afford a dynamic readout of conscious information processing. However, because stimulus onsets in their study involved shifts in luminance as well as information, they could not determine whether this coupling of stimulus …

The Basis Of Self And Other In Gender Constructed Identity, Julie L. Lemley

Journal of Undergraduate Research at Minnesota State University, Mankato

This paper is an extension of previous research projects wherein I applied theories of identity and labeling (Garfinkle), power (French and Raven) and gender (Pearson, West and Turner) to adolescent girls’ identity construction. Using methods of textual criticism, I argued then that the advertising targeting adolescent girls at the crucial transitional period between child identity and adult identity was dominated by patriarchal imagery, the implications of which are sexual violence, low-self esteem and self-objectification by young women. This paper applies the same methodology but to identity formation of adolescent boys, arguing on the basis of Hegel’s master-slave dialectic that adolescent …

A Transdiagnostic Social Skills Intervention: Using A Structured Story To Teach Children How To Ask A Friend To Play, Elizabeth Santy

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

An (independent samples comparison) controlled study was conducted to assess the efficacy of a novel approach to social skills training for children in a local socialization group at Knippenberg, Patterson & Associates (KPA). The treatment condition involved the combination of a Structured Story (i.e., novel bibliotherapy technique for children with social skills deficits), and a behavioral rehearsal (or role-play) segment, where the children practiced the target social skill featured in the Structure Story. The control group did not receive the Structured Story nor the behavioral rehearsal. Children in both groups engaged in ten-minutes of free play that was videorecorded for …

Using The R-Pas' Aggressive Content Score For The Evaluation Of Aggressive Behaviors In Children, Rebecca Dehass

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

The Rorschach Performance Assessment System (R-PAS) was developed in 2011 as an alternative to the previous Comprehensive System. The goal was to improve the psychometrics, and particularly the validity, of this assessment method. The norms for children were questionable in the Comprehensive system (e.g., outdated, low numbers of subjects) and validity studies for children were sparse. One of the indicators included in the R-PAS system, the aggressive content indicator (AgC), is intended to reflect aggressive behavior, but few studies have examined the validity of this indicator. This study examined the validity of AgC in a sample of 32 children and …

Sexy But Not Sexual: An Examination Of The Sexual Narratives Of African American Adolescent Females, April Timmons

College of Science and Health Theses and Dissertations

Much of the research on sexuality during adolescence has focused on the potential negative sequelae of adolescent sexual behavior such as STI acquisition or teenage pregnancy. Researchers have begun to advocate for examining adolescent sexuality as a normative aspect of adolescent development. One aspect of this examination would be to form a more complete understanding of how adolescents develop their sexual identity – their conceptualization of themselves as a sexual being. Erickson’s (1968) identity development theory asserts that identity is developed internally and shaped by the social environment.

Development of a healthy sexual identity may be particularly difficult for African …

Intensive Parenting: Does It Have The Desired Impact On Child Outcomes?, Holly H. Schiffrin, Hester Godfrey, Miriam Liss, Mindy J. Erchull

Psychological Science Articles

Although parental involvement is generally thought to be beneficial for children, it is unclear whether the intensive level of parenting that has become commonplace results in improved child outcomes. Intensive parenting may involve the desire to anticipate and solve children’s problems as well as to enroll them in numerous, structured activities that might enhance their physical, cognitive, and social abilities. We surveyed 241 parents to assess intensive parenting beliefs, anticipatory problem solving (APS), enrollment in structured activities, and developmental outcomes of their children ages 2–5. Using structural equation modeling, we found that intensive parenting beliefs predicted more APS, which predicted …