Digital Commons Network^™

Defining And Assessing Animal Pain, Lynne U. Sneddon, Robert W. Elwood, Shelley A. Adamo, Matthew C. Leach

Experimentation Collection

The detection and assessment of pain in animals is crucial to improving their welfare in a variety of contexts in which humans are ethically or legally bound to do so. Thus clear standards to judge whether pain is likely to occur in any animal species is vital to inform whether to alleviate pain or to drive the refinement of procedures to reduce invasiveness, thereby minimizing pain. We define two key concepts that can be used to evaluate the potential for pain in both invertebrate and vertebrate taxa. First, responses to noxious, potentially painful events should affect neurobiology, physiology and behaviour …

Modeling Hedonic Processing And Anhedonia In Depression, Kevin Mercado

Honors College Theses

Depression is characterized by low positive emotion and a lack of pleasurable experiences, or anhedonia. Past studies have emphasized controlling negative affect, but there is an emerging trend in the depression literature to focus on positive emotion. The current study employed several psychophysiological tools, postauricular reflex, startle blink reflex, and event-related potential (ERP) components such as P3 and the late positive potential (LPP), to assess the dissociable components in positive emotion (consummatory and anticipatory processes). In addition, several different hypotheses of emotional dysfunction were evaluated to accurately model deficits in positive emotionality. A majority of the psychophysiological tools used supported …

Adolescent, But Not Adult, Binge Ethanol Exposure Leads To Persistent Global Reductions Of Choline Acetyltransferase Expressing Neurons In Brain, Ryan P. Vetreno, Margaret Broadwater, Wen Liu, Linda Spear, Fulton T. Crews

Psychology Faculty Scholarship

During the adolescent transition from childhood to adulthood, notable maturational changes occur in brain neurotransmitter systems. The cholinergic system is composed of several distinct nuclei that exert neuromodulatory control over cognition, arousal, and reward. Binge drinking and alcohol abuse are common during this stage, which might alter the developmental trajectory of this system leading to long-term changes in adult neurobiology. In Experiment 1, adolescent intermittent ethanol (AIE; 5.0 g/kg, i.g., 2-day on/2-day off from postnatal day [P] 25 to P55) treatment led to persistent, global reductions of choline acetyltransferase (ChAT) expression. Administration of the Toll-like receptor 4 agonist lipopolysaccharide to …

Multi-Region Hemispheric Specialization Differentiates Human From Nonhuman Primate Brain Function, H-Y. Wey, Kimberley A. Phillips, D. R. Mckay, A. R. Laird, P. Kochunov, M. D. Davis, D. C. Glahn, T. Q. Duong, P. T. Fox

Psychology Faculty Research

The human behavioral repertoire greatly exceeds that of nonhuman primates. Anatomical specializations of the human brain include an enlarged neocortex and prefrontal cortex (Semendeferi et al. in Am J Phys Anthropol 114:224–241, 2001), but regional enlargements alone cannot account for these vast functional differences. Hemispheric specialization has long believed to be a major contributing factor to such distinctive human characteristics as motor dominance, attentional control and language. Yet structural cerebral asymmetries, documented in both humans and some nonhuman primate species, are relatively minor compared to behavioral lateralization. Identifying the mechanisms that underlie these functional differences remains a goal of considerable …

Adolescent Bisphenol-A Exposure Decreases Dendritic Spine Density: Role Of Sex And Age, Rachel E. Bowman, Victoria N. Luine, Hameda Khandaker, Joseph J. Villafane, Maya Frankfurt

Psychology Faculty Publications

Bisphenol-A (BPA), a common environmental endocrine disruptor, modulates estrogenic, androgenic, and anti-androgenic effects throughout the lifespan. We recently showed that low dose BPA exposure during adolescence increases anxiety and impairs spatial memory independent of sex. In the current study, six week old Sprague Dawley rats (n=24 males, n=24 females) received daily subcutaneous injections (40 µg/kg bodyweight) of BPA or vehicle for one week. Serum corticosterone levels in response to a 1 h restraint stress and spine density were examined at age 7 (cohort 1) and 11 (cohort 2) weeks. Adolescent BPA exposure did not alter stress dependent corticosterone responses but …

Transcranial Magnetic Stimulation Of The Prefrontal Cortex In Awake Nonhuman Primates Evokes A Polysynaptic Neck Muscle Response That Reflects Oculomotor Activity At The Time Of Stimulation., Chao Gu, Brian D Corneil

Brain and Mind Institute Researchers' Publications

Transcranial magnetic stimulation (TMS) has emerged as an important technique in cognitive neuroscience, permitting causal inferences about the contribution of a given brain area to behavior. Despite widespread use, exactly how TMS influences neural activity throughout an interconnected network, and how such influences ultimately change behavior, remain unclear. The oculomotor system of nonhuman primates (NHPs) offers a potential animal model to bridge this gap. Here, based on results suggesting that neck muscle activity provides a sensitive indicator of oculomotor activation, we show that single pulses of TMS over the frontal eye fields (FEFs) in awake NHPs evoked rapid (within ∼25 …

Fish Cognition, Redouan Bshary, Culum Brown

Social Cognition Collection

No abstract provided.

“Putting The Occupation Back In Occupational Therapy:” A Survey Of Occupational Therapy Practitioners’ Use Of Gardening As An Intervention, Amy Wagenfeld, Ben Atchison

The Open Journal of Occupational Therapy

Background. This study examines how and why occupational therapy practitioners across practice areas use gardening as an intervention. Respondents’ interpretation of the best and least desirable aspects of their facility’s garden and whether they contributed to its design was also examined.

Method. A description and link to a 15-question online survey about gardening as an occupational therapy intervention was emailed to Western Michigan University Occupational Therapy alumni and posted on four OT Connections groups and the AOTA LinkedIn site.

Results. Gardening as an occupational therapy intervention is meaningful and purposeful (93.66%, n = 56), motivating (80%, n = 48), fun …

Climate Change Survey Measures: Exploring Perceived Bias And Question Interpretation, Tarik Abdel-Monem, Lisa M. Pytlikzillig, Tonya K. Bernadt, Nicole Wall

Lisa PytlikZillig Publications

Climate change has become an important yet politically divisive topic in recent years. Further complicating the issue are assertions that climate change– related public opinion surveys used by social scientists are biased or otherwise problematic. We conducted a pilot study to explore questions concerning bias and interpretation of climate change surveys. Our study sample was composed of adult residents of Nebraska (n = 115). We augmented our survey findings with cognitive interviews of a subsample of respondents (n = 20). We assessed study participants’ attitudes about climate change, and perceptions of bias and interpretation of survey questions drawn from previously …

Further Changes In L2 Thinking For Speaking?, Gale Stam

Faculty Publications

Cross-linguistic research has shown that languages differ typologically in how motion events are indicated lexically and syntactically, and that speakers of these languages have different patterns of thinking for speaking (for a review, see Han and Cadierno, 2010). Spanish speakers express path linguistically on verbs, their path gestures tend to occur with path verbs, and their manner gestures may occur without manner in speech, whereas English satellite units, and their manner gestures rarely occur without manner in speech. Stam (2006b) has shown that the English narrations of Spanish learners of English have aspects of their first language (Spanish) and aspects …

Ua66 Ogden College Of Science & Engineering Newsletter, Cheryl Stevens, Dean

Ogden College of Science & Engineering Publications

No abstract provided.

Developmental Stress, Condition, And Birdsong: A Case Study In Song Sparrows., Kim L Schmidt, Elizabeth A Macdougall-Shackleton, Shawn P Kubli, Scott A Macdougall-Shackleton

Brain and Mind Institute Researchers' Publications

Sexual-selection theory posits that ornaments and displays can reflect a signaler's condition, which in turn is affected both by recent and developmental conditions. Moreover, developmental conditions can induce correlations between sexually selected and other traits if both types of traits exhibit developmental phenotypic plasticity in response to stressors. Thus, sexually selected traits may reflect recent and/or developmental characteristics of signalers. Here, we review data on the relationships between birdsong, a sexually selected trait, and developmental and current condition of birds from a long-term study of a population of song sparrows (Melospiza melodia). Field studies of free-living birds indicate that the …

Optimization Of Switch Virtual Keyboard By Using Computational Modelling, Xiao Zhang

Open Access Theses

In this thesis, I first reviewed some keyboard technologies used by people with motor difficulties, and described design elements that influence efficiency. I cast the design of a switch keyboard as an optimization problem, and arrangement of keys on such a keyboard as a Mixed Integer Programming problem. One significant variable in the MIP problem, the error rate, is related to several other variables. I treated modeling of the error rate as a parameter estimation problem, and used a data mining method. I designed HCI experiments to gather data for parameter estimation, using Bayesian logistic regression model. The empirical data …

Botulinum Toxin-Induced Facial Muscle Paralysis Affects Amygdala Responses To The Perception Of Emotional Expressions: Preliminary Findings From An A-B-A Design, M. Justin Kim, Maital Neta, F. Caroline Davis, Erika J. Ruberry, Diana Dinescu, Tood F. Heatherton, Mitchell A. Scotland, Paul J. Whalen

Department of Psychology: Faculty Publications

Background: It has long been suggested that feedback signals from facial muscles influence emotional experience. The recent surge in use of botulinum toxin (BTX) to induce temporary muscle paralysis offers a unique opportunity to directly test this “facial feedback hypothesis.” Previous research shows that the lack of facial muscle feedback due to BTX-induced paralysis influences subjective reports of emotional experience, as well as brain activity associated with the imitation of emotional facial expressions. However, it remains to be seen whether facial muscle paralysis affects brain activity, especially the amygdala, which is known to be responsive to the perception of …

The Impact Of An Omega-3 Enriched Diet On Hyperactivity And Biochemistry In An Animal Model For Attention-Deficit/Hyperactivity Disorder, Nadine M. Hammoud

Open Access Theses

Attention-deficit/hyperactivity disorder (ADHD) is the most diagnosed behavioral disorder in children. It affects around 5% of children worldwide and 11% of children in the United States, with rates increasing. Pharmaceutical treatments, such as amphetamines and methylphenidates, are not effective for everyone and are known to have unwanted side effects. While the etiology of the disorder is not yet fully understood, there are clear genetic and environmental components. Nutritional insufficiencies have recently become a popular environmental risk factor under investigation. Essential fatty acids (EFA), omega-3 polyunsaturated fatty acids (PUFA) in particular, are needed for proper brain development and function. Our lab …

Multidimensional Approach To Comparative Avian Visual Systems, Bret Alan Moore

Open Access Dissertations

Since the birth of visual ecology, comparative studies on how birds see their world have been limited to a small number of species and tended to focus on a single visual trait. This approach has constrained our ability to understand the diversity and evolution of the avian visual system. The goal of this dissertation was to characterize multiple visual dimensions on bird groups that are highly speciouse (e.g., Passeriformes), and test some hypotheses and predictions, using modern comparative tools, on the relationship between different visual traits and their association with visual information sampling behaviors. First, I developed a novel method …

Role Of Group Ii Metabotropic Glutamate Receptor Subtype 2 (Mglur2) In Appetitive And Consummatory Aspects Of Ethanol Reinforcement, Kyle Allyson Windisch

Open Access Dissertations

Background: Group II metabotropic glutamate receptors (mGluR2/3) are predominately presynaptically located G_i/o coupled receptors that are highly expressed in the cortex, nucleus accumbens, amygdala, and hippocampus. Previous studies suggest that group II mGluRs are involved in regulating ethanol (EtOH) consumption and seeking following extinction (Backstrom and Hyytia, 2005; Kufahl, et al., 2011). The sipper tube model, which allows for procedural separation of seeking and consumption, was used to further clarify the role of mGluR2/3 in EtOH-seeking and consumption. The non-selective group II mGluR agonist LY379268 (LY37) and selective mGluR2 positive allosteric modulator (PAM) BINA were used to determine the …

Security Policies That Make Sense For Complex Systems: Comprehensible Formalism For The System Consumer, Rhonda R. Henning

CCAC Theses and Dissertations

Information Systems today rarely are contained within a single user workstation, server, or networked environment. Data can be transparently accessed from any location, and maintained across various network infrastructures. Cloud computing paradigms commoditize the hardware and software environments and allow an enterprise to lease computing resources by the hour, minute, or number of instances required to complete a processing task. An access control policy mediates access requests between authorized users of an information system and the system's resources. Access control policies are defined at any given level of abstraction, such as the file, directory, system, or network, and can be …

Utopias Misplaced: The Cost Of Outsourcing Dystopian Poetics To North Korea, Seo-Young J. Chu

Publications and Research

This is a slightly revised version of the text of a talk that I (Seo-Young Chu) gave as part of the Fall 2014 Franke Lectures in the Humanities at Yale University. I'm sharing the text here to make the lecture more accessible. Topics include: North Korea/the DPRK, the "uncanny body politic," the uncanny valley, "dystopian poetics," what it means to outsource dystopian poetics, the intersection of aesthetics and politics. Authors/artists mentioned include: Thomas Hobbes, Mary Shelley, David Mitchell, Marjane Satrapi, Song Byeok, Sun Mu, Masahiro Mori, Andy Warhol. The talk also discusses the James Bond film Die Another Day.

Differential Effects Of Intermittent Versus Continuous Haloperidol Treatment Throughout Adolescence On Haloperidol Sensitization And Social Behavior In Adulthood, Jun Gao, Ming Li

Department of Psychology: Faculty Publications

Animal work on the behavioral effects of antipsychotic treatment suggests that different dosing regimens could affect drug sensitivity differently, with an intermittent treatment regimen tending to cause a sensitization effect, while a continuous treatment causing a tolerance. In this study, we explored how haloperidol (HAL) sensitization induced throughout adolescence and tested in adulthood was differentially impacted by these two dosing regimens in the conditioned avoidance response (CAR) test.We also examined howthese two dosing regiments affected social interaction and social memory in adulthood. Male adolescent Sprague-Dawley rats were treated with HAL via either osmotic minipump(HAL-0.25 CONT; 0.25mgkg⁻¹ day⁻¹, …

Biological Motion Processing In Typical Development And In The Autism Spectrum, Aaron Krakowski

Dissertations, Theses, and Capstone Projects

Biological motion (BM) analysis and interpretation is a fundamental process of human neurocognition that has been only minimally explored neurophysiologically. In addition to its importance in understanding the underlying roots and development of social cognition, BM processing is a prime candidate domain for exploring the underlying etiology of social cognitive disorders such as the autism spectrum.

In an initial experiment, typical adults observed BM point-light displays of a human actor (UM) as well as their spatially scrambled counterparts (SM), in both an unattended distractor task as well as an explicit attention task. Results showed a neurophysiological response manifested as three …

Conflict And Playmaking: The Impact Of A Recess Enhancement Program On Elementary School Playgrounds In New York City, Elizabeth Lake

Dissertations, Theses, and Capstone Projects

As time demands for schooling increase and children's freedom to play is under threat, the question of how play during school recess can best be designed to serve children has grown in importance. This research examines whether a peer-training program can influence children's activity choices and social behaviors and reduce conflict on elementary school playgrounds during recess and what aspects of such a peer-training program are important to this goal. Three general recess issues are considered: conflict, activity level and choice, and gender inclusion. The data was collected as part of a Recess Enhancement Program in a select group of …

The Effects Of Environmental Enrichment On Abstinence And Relapse Using An Animal Conflict Model, Joshua Alan Peck

Dissertations, Theses, and Capstone Projects

Heroin addiction is a significant health and societal problem for which there is no effective and well-accepted long-term behavioral or pharmacological treatment. Therefore, strategies that prolong heroin abstinence should be the primary focus of heroin treatment research. There is promising evidence that environmental enrichment may indeed support drug abstinence in animals using the reinstatement model of abstinence and relapse. The current studies used an animal conflict model that captures the aversive consequences of drug seeking (as are typical in humans, e.g., arrest, incarceration, job loss, and strained social relationships) to test the effects of environmental enrichment on heroin abstinence, prolonged …

The Influence Of An Appetitive Conditioned Stimulus On Interval Timing Behavior, Joseph Daniel Jacobs

Dissertations, Theses, and Capstone Projects

Pavlovian incentive motivation provides a theoretical framework on the basis of which experiments can be designed to examine the effects of motivational variables on timing behavior. The Pavlovian-Instrumental transfer (PIT) paradigm is a prototype for studying Pavlovian incentive motivation. The current study examined the effect of a Pavlovian appetitive conditioned stimulus (CS) on timing performance, based on the PIT paradigm. Nine pigeons were exposed to pairings of a 120-s conditioned stimulus (flashing or steady houselight) and unconditioned stimulus (food). The pigeons were then trained on the peak procedure (FI 30 s). In a subsequent testing phase, the effect of the …

Executive Dysfunction And Reward Dysregulation: Interactions In Drug Addiction, Kristen Paula Morie

Dissertations, Theses, and Capstone Projects

Cocaine addiction is a serious public health hazard, and contributes to disastrous outcomes for individuals who suffer from it. Addiction is accompanied by an inability to control one's own behavior, and a preoccupation with cocaine at the expense of other rewarding pursuits. Previous research has suggested that difficulties with executive function and reward processing may underlie these problems, but the extent to which each contributes to addiction severity, or how these two factors may interact, remains to be elucidated. By using event related potential (ERP) measures in combination with information about self-reported anhedonia over three experiments, we set out to …

Cognitive And Emotional Abnormalities In People With Systemic Lupus Erythematosus, Philip Watson

Dissertations, Theses, and Capstone Projects

Systemic lupus erythematosus (SLE) is a multi-system autoimmune disorder characterized by the production of autoantibodies (ABs). Approximately 30-50% of patients produce ABs directed against N-Methyl-D-aspartic acid receptors (NMDARs). Previous research with animals has identified these ABs as being associated with amygdala damage and a deficit in fear conditioning. People with SLE can have damage to the amygdala. This study aimed to determine if emotional processing deficits occur in people with SLE and to associate such deficits, if they exist, with anti-NMDAR AB presence, length of disease, cognition, and mood. Fifty-eight (11 AB+, 24 AB-, 23 healthy) women participated in tasks …

Age-Related Aspects Of Mirror-Use By Bottlenose Dolphins (Tursiops Truncatus), Rachel A. Morrison

Dissertations, Theses, and Capstone Projects

Bottlenose dolphins are neuroanatomically different and evolutionarily divergent from primates yet they exhibit mirror self-recognition (MSR), a rare cognitive ability in non-human animals. This research investigated the developmental and age-related aspects of MSR in this species. During a longitudinal study, a social group of bottlenose dolphins at the National Aquarium, Baltimore, MD were exposed to a mirror and their behavioral responses were recorded to: 1) further confirm the presence of MSR in this species, 2) determine the age of emergence of MSR and 3) draw comparisons with data documenting the emergence of this ability in humans and great ape species. …

Identifying Tier-Two At Risk Students In New Jersey Public Schools, Danisha Moodie

Theses and Dissertations

Actions to improve student's socio-emotional success in public education by attempting to identify, and eliminate bullying behaviors within educational institution are a key focus for many educators. Harassment, intimidation and bullying behaviors (HIB) are recognized as a solemn issue across the nation. According to the Anti-Bullying Bill of Rights Act, public schools are required to report (HIB) incidents to the New Jersey Department of Education. Moreover, coupled with the mandated guidelines of this new legislation many public schools within New Jersey have also adopted positive behavior interventions. This may help in identifying at-risk students who may require a greater level …

The Facial Feedback Hypothesis: Does It Apply To People With Schizophrenia?, Emily Drake

Psychology and Counseling Theses

The Facial Feedback Hypothesis (FFH) states that emotions are induced or enhanced by one's own facial expression. Lack of accurate empathy, deficits in the ability to read facial expressions, and anhedonia are all symptoms found in schizophrenia. These symptoms have a dramatic impact on schizophrenia patients; the levels of those symptoms often determining functional outcome. Few studies exist on facial feedback in schizophrenia and those that do are conflicting in their views as to whether or not FFH applies to people with schizophrenia. This study measured level of positive affect and how it is affected by facial expression. Controls assigned …

The Immersive Medium: Art, Flow, And Video Games, Christopher M. Yalen

Oglethorpe Journal of Undergraduate Research

In this article, the question of whether or not video games could be considered art is explored, as well as what this means for video games as cultural products. Using an interdisciplinary approach, I suggest that there are some games we can consider “art”, and that these games are not only different aesthetically speaking, but are also different from a media-effects standpoint. The article consists of three main sections, an aesthetic review, a content analysis, and a pilot study. In the aesthetic review, I employ different perspectives from aesthetic philosophy in order to come up with criteria for what an …