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Articles 7201 - 7230 of 12661
Full-Text Articles in Entire DC Network
Striatal Activity Is Associated With Deficits Of Cognitive Control And Aberrant Salience For Patients With Schizophrenia, Alan E. Ceaser
Striatal Activity Is Associated With Deficits Of Cognitive Control And Aberrant Salience For Patients With Schizophrenia, Alan E. Ceaser
Arts & Sciences Graduate Student Theses and Dissertations
A recent study has shown that the locus of the largest known dopamine abnormality between patients with schizophrenia and healthy controls is in the associative striatum (Kegeles et al., 2010). This dopamine abnormality in the associative striatum is thought to bring about aberrant salience assignment for patients, which may underlie symptoms of psychosis like delusions and hallucinations (Howes & Kapur, 2009). Interestingly, the associative striatum has segregated, looped, connectivity with cortical regions including the prefrontal and parietal cortices (Draganski et al., 2008; Redgrave, Vautrelle, & Reynolds, 2011) and computational models have suggested that it may function as an information gate …
Relationship Between Serum Biomarkers And Three-Month Outcomes Following Pediatric Traumatic Brain Injury (Tbi), Alicia Leanne Janos
Relationship Between Serum Biomarkers And Three-Month Outcomes Following Pediatric Traumatic Brain Injury (Tbi), Alicia Leanne Janos
Arts & Sciences Graduate Student Theses and Dissertations
With more than 475,000 cases annually, traumatic brain injury (TBI) is the leading cause of morbidity and mortality in children. Promising new tools for the prediction of functional outcomes following pediatric TBI are biomarkers of brain injury that can be detected in blood serum. The most commonly studied biomarkers, S100β, neuron-specific enolase (NSE), and myelin basic protein (MBP), have myriad limitations which preclude their use in clinical care. In the present study, serum concentrations of two novel biomarkers of brain injury (i.e., ubiquitin carboxy-terminal hydrolase-L1, UCH-L1; glial fibrillary acidic protein, GFAP) were collected 24 hours following severe TBI in 30 …
Gesture As Revelation, Laurel Panella
Gesture As Revelation, Laurel Panella
Graduate School of Art Theses
Abstract
The two divergent paths of fine arts and psychological research come together to demonstrate how physical gesture and facial expression communicates significant meaning regarding human emotion and intention. The conceptual framework of these paintings arises from the artist’s engagement with peer-reviewed psychological studies on Affective Science. The paintings balance qualities of both emotional and intellectual thinking, with the goal of calling them forth in equal strength during the viewing experience. The symbolic and representational language of gesture is examined through the painting titled Precarious Extension. Dynamics of compassion and affect theory are analyzed through the painting Transmission of …
The Influence Of Word Frequency And Aging On Lexical Access, Emily Rebecca Cohen-Shikora
The Influence Of Word Frequency And Aging On Lexical Access, Emily Rebecca Cohen-Shikora
Arts & Sciences Graduate Student Theses and Dissertations
Visual word recognition has been a central area of psychological inquiry over the past century. The current dissertation examines how visual word recognition changes as a function of age by focusing on the influence of word frequency, or how commonly a word is encountered. Word frequency is arguably the strongest predictor of visual word recognition performance across a variety of language tasks, and the most influential factor in models of language processing. All models of visual word recognition include a strong role for word frequency but often assume different underlying mechanisms, which produce differing predictions for age changes. Although there …
Manipulation Of Negative Social Evaluative Fears On Body Dissatisfaction And Eating Behaviors: Does Fear Of Social Evaluation Lead To Disordered Eating?, Cheri A. Levinson
Manipulation Of Negative Social Evaluative Fears On Body Dissatisfaction And Eating Behaviors: Does Fear Of Social Evaluation Lead To Disordered Eating?, Cheri A. Levinson
Arts & Sciences Graduate Student Theses and Dissertations
Social anxiety and eating disorders are highly comorbid. Researchers have suggested that there may be shared vulnerabilities that underlie the development of these disorders. Two of these proposed vulnerabilities are fear of negative evaluation and social appearance anxiety (i.e., fear of negative evaluation specifically focused on one’s appearance). Regarding disordered eating, previous self-report research has found that social appearance anxiety may be especially relevant for body dissatisfaction, whereas fear of negative evaluation may be relevant for drive for thinness. In the current study I manipulated fear of negative evaluation and social appearance anxiety using a speech task in 160 undergraduate …
A Comparison Of Measurement Systems To Score Sleep Disturbance For Children With Autism Spectrum Disorders, Aaron Lesser
A Comparison Of Measurement Systems To Score Sleep Disturbance For Children With Autism Spectrum Disorders, Aaron Lesser
Theses & Dissertations
Direct observation of children’s sleep disturbance in the home is critical to understanding child behavior while awake and determining qualitative features of the sleep environment, but obtaining these data from an in-home recorded video, second-by-second, is impractical in terms of scoring time because observers score when the child is asleep and awake. In Studies 1 and 2, we conducted an analog study to assess a motion-detection camera to determine whether it would be suitable to measure children’s sleep disturbance. In Study 3, we obtained in-home measures of sleep disturbance for three children with an autism spectrum disorder using a motion-detection, …
The Shared Experiences Of Counselors Who Practice In Natural Environments, Bonnie King
The Shared Experiences Of Counselors Who Practice In Natural Environments, Bonnie King
LSU New Orleans Theses and Dissertations
The purpose of this qualitative, phenomenological study was to gain a deep understanding of the shared experiences of therapists who provide counseling in non-traditional, natural environment settings. Eight participants shared their experiences about counseling in nature. The primary research question for this study was: What are the shared experiences of counselors who provide nature-based counseling? A review of the literature of nature-based counseling provided benefits to spending time in nature, descriptions of various types of nature-based counseling, and ethical and legal issues that affect nature-based counselors.
Semi-structured interviews comprised of open-ended questions were used to collect data by phone and …
The Predictive Utility Of Emotional Deficits And Callous-Unemotional Traits For Important Antisocial Outcomes In Juvenile Justice-Involved Youth, Laura C. Thornton
The Predictive Utility Of Emotional Deficits And Callous-Unemotional Traits For Important Antisocial Outcomes In Juvenile Justice-Involved Youth, Laura C. Thornton
LSU New Orleans Theses and Dissertations
The current study investigated the predictive utility of callous-unemotional (CU) traits and emotional facilitation to distress (EFD) for multiple antisocial outcomes in a sample of juvenile justice-involved males. Although CU traits and EFD did not generally interact to predict antisocial outcomes, CU traits were a consistent predictor of total, proactive, and reactive forms of aggression over 18 months. Similarly, CU traits and time interacted to predict total and violent self-reported offending, such that CU traits were positively associated with both outcomes, but this association weakened over the 18 month timeframe. Racial and ethnic differences only emerged for the prediction of …
Comprehensive Functional Characterization Of Murine Infantile Batten Disease Including Parkinson-Like Behavior And Dopaminergic Markers, George Taylor, Joshua Dearborn, Steven Harmon, Stephen Fowler, Karen O’Malley, Mark Sands, David Wozniak
Comprehensive Functional Characterization Of Murine Infantile Batten Disease Including Parkinson-Like Behavior And Dopaminergic Markers, George Taylor, Joshua Dearborn, Steven Harmon, Stephen Fowler, Karen O’Malley, Mark Sands, David Wozniak
Psychology Faculty Works
Infantile neuronal ceroid lipofuscinosis (INCL, Infantile Batten disease) is a neurodegenerative lysosomal storage disease caused by a deficiency in palmitoyl protein thioesterase-1 (PPT1). The PPT1-deficient mouse (Cln1−/−) is a useful phenocopy of human INCL. Cln1−/− mice display retinal dysfunction, seizures, motor deficits, and die at ~8 months of age. However, little is known about the cognitive and behavioral functions of Cln1−/− mice during disease progression. In the present study, younger (~1–2 months of age) Cln1−/− mice showed minor deficits in motor/sensorimotor functions while older (~5–6 months of age) Cln1−/− mice exhibited more severe impairments, including decreased locomotor activity, inferior cued …
Responses Of Primate Frontal Cortex Neurons During Natural Vocal Communication, Cory T. Miller, A. Wren Thomas, Samuel U. Nummela, Lisa A. De La Mothe
Responses Of Primate Frontal Cortex Neurons During Natural Vocal Communication, Cory T. Miller, A. Wren Thomas, Samuel U. Nummela, Lisa A. De La Mothe
Psychological Sciences and Counseling Faculty Research
The role of primate frontal cortex in vocal communication and its significance in language evolution have a controversial history. While evidence indicates that vocalization processing occurs in ventrolateral prefrontal cortex neurons, vocal-motor activity has been conjectured to be primarily subcortical and suggestive of a distinctly different neural architecture from humans. Direct evidence of neural activity during natural vocal communication is limited, as previous studies were performed in chair-restrained animals. Here we recorded the activity of single neurons across multiple regions of prefrontal and premotor cortex while freely moving marmosets engaged in a natural vocal behavior known as antiphonal calling. Our …
School Psychologists’ Training And Knowledge Of Tourette Syndrome, Leticia Cornejo
School Psychologists’ Training And Knowledge Of Tourette Syndrome, Leticia Cornejo
Educational Studies Dissertations
A web-based survey was conducted that included 97 practicing school psychologists in California. The results from the survey indicated that the majority (88%) of respondents were knowledgeable about Tourette Syndrome. Many respondents (28%) had never worked with a student with Tourette’s, 20% had at least one case, and 52% indicated that they had worked with more than two cases in their careers as school psychologists. The majority of respondents indicated that their school psychology program did not adequately train them to assess or counsel students with Tourette’s. The majority of participants also did not feel confident to work with students …
Contrasting Styles In Cognition And Behaviour In Bumblebees And Honeybees., David F Sherry, Caroline G Strang
Contrasting Styles In Cognition And Behaviour In Bumblebees And Honeybees., David F Sherry, Caroline G Strang
Psychology Publications
Bumblebees and honeybees have been the subjects of a great deal of recent research in animal cognition. Many of the major topics in cognition, including memory, attention, concept learning, numerosity, spatial cognition, timing, social learning, and metacognition have been examined in bumblebees, honeybees, or both. Although bumblebees and honeybees are very closely related, they also differ in important ways, including social organization, development, and foraging behaviour. We examine whether differences between bumblebees and honeybees in cognitive processes are related to differences in their natural history and behaviour. There are differences in some cognitive traits, such as serial reversal learning and …
The Neuropsychological Profile Of Older Adult Musicians And Non-Musicians : Implications For Cognitive Reserve In Late Life., Jessica Vemich Strong,
The Neuropsychological Profile Of Older Adult Musicians And Non-Musicians : Implications For Cognitive Reserve In Late Life., Jessica Vemich Strong,
Electronic Theses and Dissertations
Published literature studying children and adults musicians suggests significant differences in neuroanatomy, in brain regions that include the auditory and motor cortices, language centers, and frontal regions and tracts. Studies examining cognitive correlates to these neuroanatomical differences have consistently found that children and adult musicians have better cognitive abilities in the domains of language, verbal or non-verbal memory and executive function. Only one study has examined the differences in cognitive performance between older adult musicians and non-musicians to see how normal age-related cognitive changes may affect these differences. The current study compared cognitive test performance among older adult non-musicians, low-activity …
What We See Changes How We See : Analyzing The Plasticity Of The Horizontal Effect., April Marie Schweinhart
What We See Changes How We See : Analyzing The Plasticity Of The Horizontal Effect., April Marie Schweinhart
Electronic Theses and Dissertations
The relationship between the processing of orientations by the human visual system has been related to the orientation content of the natural environment; horizontal orientations, while predominant in natural environments, are perceived less well than vertical and oblique orientations are perceived best, though they are least prevalent in the natural world. This ‘horizontal effect’ has further extended the well-studied relationship between visual encoding and natural scene statistics as the differential perception of orientations in broadband scenes inversely matches their differential representation in the natural environment. However, the original hypothesis that this relationship may have evolved across millennia in order to …
Kin Selection, Raymond Hames
Kin Selection, Raymond Hames
Department of Anthropology: Faculty Publications
When Hamilton (1964) published his theory of inclusive fitness it had no immediate impact in the social and behavioral sciences, even though ethnographers knew kinship to be a universally fundamental factor in human social organization, especially in egalitarian societies in which humans have spent nearly all their evolutionary history. In many ways, it was a theory that perhaps anthropologists should have devised: Anthropologists knew kinship fundamentally structured cooperation, identity, coalition formation, resource exchange, marriage, and group membership in traditional societies. It was not until 1974 with the publication of Wilson’s Sociobiology (1975) and especially Richard Alexander’s The Evolution of Social …
Phase Change Lines, Scale Breaks And Trend Lines Using Excel 2013Tm, Neil Deochand
Phase Change Lines, Scale Breaks And Trend Lines Using Excel 2013Tm, Neil Deochand
Masters Theses
The development of graphing skills for the behavior analyst is an ongoing process. Specialized graphing software is often expensive, not widely disseminated, and may require specific training. Dixon, et al. (2009) provided an updated task analysis (Carr & Burkholder, 1998) in the widely used platform Excel 2007. Vanselow and Bourret (2012) provided online tutorials outlining some alternate methods also using Office 2007. This article serves as an update to those task analyses with alternative and under-utilized methods in Excel 2013. To examine the utility of our recommendations twelve psychology graduate students were presented with the task analyses and the experimenters …
A Comparison Of The Effects Of Choice And Differential Reinforcement On The Computation Fluency Of Students With Escape-Maintained Academic Performance Problems, Maureen A. O'Connor
A Comparison Of The Effects Of Choice And Differential Reinforcement On The Computation Fluency Of Students With Escape-Maintained Academic Performance Problems, Maureen A. O'Connor
College of Education and Human Sciences: Dissertations, Theses, and Student Research
This dissertation compared antecedent- and consequence-based strategies to determine which treatments or combination of treatments produced the strongest improvements in math computation fluency with four elementary-aged students who displayed escape-motivated behaviors. Functional analyses were conducted to identify elementary-school students whose academic responding was under a negative-reinforcement contingency. Next, a preference assessment was administered to each student to identify potentially effective reinforcers in the form of permissible school activities. These high-preference activities were used during the DRA and Task-Choice + DRA conditions. A multielement design was used to examine the impact of four treatments – Task Choice, DRA, Task Choice+DRA, and …
Saliva Cotinine As A Measure Of Abstinence In A Lottery-Based Contingency Management Treatment For Smoking Cessation, Catherine M. Gayman
Saliva Cotinine As A Measure Of Abstinence In A Lottery-Based Contingency Management Treatment For Smoking Cessation, Catherine M. Gayman
Dissertations
Contingency management decreases smoking by delivering monetary incentives contingent upon objective verification of abstinence. The present study investigated the effectiveness of monitoring saliva cotinine twice weekly in a contingency-management treatment for cigarette smoking using a cash prize-based payment system. Participants were randomly assigned to either a contingent reinforcement group or a non-contingent reinforcement group. The study began with five consecutive Baseline days during which participants smoked as usual, and was followed by four consecutive Shaping days, during which participants were asked to gradually decrease smoking. During the subsequent three-week Abstinence phase, participants submitted saliva cotinine and breath carbon monoxide samples …
Pedagogical Approaches To Multicultural Education Within Teacher Preparation Programs, Mark Steven Barajas
Pedagogical Approaches To Multicultural Education Within Teacher Preparation Programs, Mark Steven Barajas
Dissertations
Despite national standards established in 1979, U.S. teacher preparation programs have struggled to incorporate comprehensive, multicultural teacher education into existing curriculum (Sleeter, 2008). The weakness of multicultural training in most teacher preparation programs is theorized as a major contributor to the persistent achievement gap between students of color and White students (Ferguson, 2003). Furthermore, literature indicates White teachers frequently hold lower expectations for racial and ethnic minority students compared to White students and these lowered expectations often manifest as lower academic achievement (McKown & Weinstein, 2007).
This study provides empirical data regarding multicultural education within teacher preparation programs. Individual course …
Assessing The Interpersonal Effectiveness Of The Dear-Man Skill Using A Social Psychology Paradigm, Matthew T. Jameson
Assessing The Interpersonal Effectiveness Of The Dear-Man Skill Using A Social Psychology Paradigm, Matthew T. Jameson
Dissertations
For more than 50 years, social psychology has investigated persuasion techniques intended to facilitate influencing the behavior of others. This body of research has identified a variety of effective techniques and principles (see Cialdini, 2007). Over roughly the same period, clinical psychologists developed interventions targeting assertiveness, the ability to influence others in socially appropriate ways (see Long, Long, & Whitson, 2009) and the related construct “interpersonal effectiveness,” the ability to influence others without harming relationships or self-respect (Linehan, 2015, pp. 231-237). A literature review conducted by the author was unable to identify linkages between these two related areas of inquiry. …
Learning To Learn And Naming Through Receptive And Expressive Identification, Kelli Perry
Learning To Learn And Naming Through Receptive And Expressive Identification, Kelli Perry
Dissertations
Poor or no language skills are typical of most preschool children with autism (American Psychological Association, 2013). Language can be divided into the two components of receptive, or listener, skills and expressive, or speaker, skills. Recommendations for sequencing language instruction vary across the different behavior-analytic instructional models (Lovaas, 1981; Barbara & Rasmussen, 2007; Sundberg & Partington, 1998; Sundberg, 2008). The current study sought to examine those recommendations using young children (three- to four-years-old) with limited vocal repertoires and to explore the acquisition of learning to learn (Harlow, 1949) and naming (Greer & Ross, 2007). This research (1) adds to the …
The Nature Of Social Relationships In Bottlenose Dolphins (Tursiops Truncatus): Associations And The Role Of Affiliative, Agonistic, And Socio-Sexual Behaviors, Briana Nicole Harvey
The Nature Of Social Relationships In Bottlenose Dolphins (Tursiops Truncatus): Associations And The Role Of Affiliative, Agonistic, And Socio-Sexual Behaviors, Briana Nicole Harvey
Master's Theses
Little is known about the specific behavioral exchanges that occur on a day-to-day basis between dyads of bottlenose dolphins (Tursiops truncatus). This thesis assesses proximity between dyads (~ 2 meters) and the proportion of time that is spent in either an affiliative, agonistic, or socio-sexual context within age/sex pairings of dolphins in order to better understand the nature of social relationships in this species. Observations of bottlenose dolphins housed at the Roatan Institute of Marine Sciences, collected in 2010, provided 10.5 hours of underwater footage for assessment of association coefficients and proportions of interactions. These data suggested similar …
Zebrafish And Conditioned Place Preference: A Translational Model Of Drug Reward, Adam Douglas Collier
Zebrafish And Conditioned Place Preference: A Translational Model Of Drug Reward, Adam Douglas Collier
Master's Theses
Addiction and substance abuse commonly lead to negative outcomes such damaged health, domestic violence, child abuse, failure in school, and loss of employment. In the United States, hundreds of billions of dollars accrue annually in costs associated with healthcare, crime and lost productivity due to addiction. Efficacious treatments remain few in number, the development of which will be facilitated by comprehension of environmental, genetic, pharmacological and neurobiological mechanisms implicated in the pathogenesis of addiction. The zebrafish (Danio rerio) has recently gained popularity as a model organism of complex brain disorders (e.g., substance use disorder). Behavioral quantification within the conditioned place …
Prefrontal Cortex Activity During Attentional Bias Conditioning With Fearful Faces: A Near-Infrared Spectroscopy Analysis, Robert D. Torrence
Prefrontal Cortex Activity During Attentional Bias Conditioning With Fearful Faces: A Near-Infrared Spectroscopy Analysis, Robert D. Torrence
All NMU Master's Theses
Observing a fearful facial expression elicits an automatic orienting of attention. Past research focusing on fear conditioning has used an unconditioned stimulus that the participant directly experiences (e.g. shock). Other research has focused on observational fear learning where the participant watches another individual receive the stimulus. The aim of this study was to condition a colored square with a fearful face in the dot-probe task. Orienting toward and disengagement from fearful faces was also examined using the dot-probe task. In addition, hemodynamic responses in the prefrontal cortex (PFC) were measured using near-infrared spectroscopy (NIRS). It was hypothesized that after pairing …
An Analysis Of The Interaction Of Methylphenidate And Nicotine In Adolescent Rats: Effects On Bdnf, Elizabeth D. Freeman
An Analysis Of The Interaction Of Methylphenidate And Nicotine In Adolescent Rats: Effects On Bdnf, Elizabeth D. Freeman
Electronic Theses and Dissertations
This investigation was an analysis of the interaction of adolescent exposure to methylphenidate (MPH; trade name: Ritalin) on nicotine sensitization and conditioned place preference (CPP) in a rodent model and underlying mechanisms of this effect. Animals were treated IP with 1 mg/kg MPH or saline using a ―school day‖ regimen of five days on, two days off, from postnatal day (P) 28-50. During the final two weeks of MPH treatment, animals were either behaviorally sensitized to nicotine (0.5 mg/kg free base) or saline for 10 days, or conditioned to nicotine or saline using the CPP behavioral paradigm. In addition, three …
The Development Of Language And Identity: A Sociocultural Study Of Five International Graduate Students Living In The U.S., Alexandra Dema
The Development Of Language And Identity: A Sociocultural Study Of Five International Graduate Students Living In The U.S., Alexandra Dema
UNLV Theses, Dissertations, Professional Papers, and Capstones
The purpose of this sociocultural study was to analyze the longitudinal process of identity development of international graduate students as their lives unfolded across time and experience in the second languaculture. Furthermore, it was aimed at exploring what role is attributed to second language in this process. The study relied on the mainstream sociocultural perspectives on individual development that originated from Vygotsky’s work and were further elaborated by his followers to address the issues of identity and language development of second language learners. As part of such perspectives, it integrated the unit of perezhivanie into the examination of individual experiences …
Temporal Information Processing Across Primary Visual Cortical Layers In Normal And Red Light Reared Tree Shrews., Wenhao Dang
Temporal Information Processing Across Primary Visual Cortical Layers In Normal And Red Light Reared Tree Shrews., Wenhao Dang
Electronic Theses and Dissertations
Visual neuroscience research has benefitted from decades of efforts of comparative studies of different species, since exploring and understanding the diversity of functional properties of visual system in different species has helped us identify both general organization rules and unique traits of certain species. In this study, spatio-temporal receptive fields (STRFs), together with some other functional properties (etc. stimulus preference to different visual stimuli, orientation tuning, temporal frequency tuning and the F1/F0 ratio of responses to sine-wave grating stimuli), of primary visual cortex (V1) cells were measured in normally reared and red-light reared tree shrews (Tupaia), a species considered the …
Inversion Effects Reveal Dissociations In Facial Expression Of Emotion, Gender, And Object Processing, Pamela M. Pallett, Ming Meng
Inversion Effects Reveal Dissociations In Facial Expression Of Emotion, Gender, And Object Processing, Pamela M. Pallett, Ming Meng
Dartmouth Scholarship
To distinguish between high-level visual processing mechanisms, the degree to which holistic processing is involved in facial identity, facial expression, and object perception is often examined through measuring inversion effects. However, participants may be biased by different experimental paradigms to use more or less holistic processing. Here we take a novel psychophysical approach to directly compare human face and object processing in the same experiment, with face processing broken into two categories: variant properties and invariant properties as they were tested using facial expressions of emotion and gender, respectively. Specifically, participants completed two different perceptual discrimination tasks. One involved making …
The Emphasis Of Physical Activity Across The Curriculum; A Positive Approach To Increased Academic Achievement, Alexandra Maldonado
The Emphasis Of Physical Activity Across The Curriculum; A Positive Approach To Increased Academic Achievement, Alexandra Maldonado
Theses and Dissertations
The purpose of this study was to assess whether physical activity has an effect on academic achievement in students. The presence of a physically active lifestylehas received much support due to its physiological and mental benefits. The establishment of such a lifestyle should begin at an early age; however, there has been a recent shift away from physically active programming within the school system that could perpetuate a healthier future. Pressure to increase academic achievement has led to the reduction and elimination of opportunities for physical activity, but these actions could have an adverse impact on students (Mahar, Murphy, Rowe, …
Serotonergic Regulation Of Prefrontal Cortical Circuitries Involved In Cognitive Processing: A Review Of Individual 5-Ht Receptor Mechanisms And Concerted Effects Of 5-Ht Receptors Exemplified By The Multimodal Antidepressant Vortioxetine, Steven C. Leiser, Yan Li, Alan Pehrson, Elena Dale, Gennady Smagin, Connie Sanchez
Serotonergic Regulation Of Prefrontal Cortical Circuitries Involved In Cognitive Processing: A Review Of Individual 5-Ht Receptor Mechanisms And Concerted Effects Of 5-Ht Receptors Exemplified By The Multimodal Antidepressant Vortioxetine, Steven C. Leiser, Yan Li, Alan Pehrson, Elena Dale, Gennady Smagin, Connie Sanchez
Department of Psychology Faculty Scholarship and Creative Works
It has been known for several decades that serotonergic neurotransmission is a key regulator of cognitive function, mood, and sleep. Yet with the relatively recent discoveries of novel serotonin (5-HT) receptor subtypes, as well as an expanding knowledge of their expression level in certain brain regions and localization on certain cell types, their involvement in cognitive processes is still emerging. Of particular interest are cognitive processes impacted in neuropsychiatric and neurodegenerative disorders. The prefrontal cortex (PFC) is critical to normal cognitive processes, including attention, impulsivity, planning, decision-making, working memory, and learning or recall of learned memories. Furthermore, serotonergic dysregulation within …