Digital Commons Network^™

The Relationship Between Hallucinations And Visuospatial Impairment Among Individuals With Dementia, Ruta Sohoni

Theses and Dissertations

Objective: This study examines the neuropsychological functioning, specifically using the Hooper Visual Organization Test (VOT), to understand the impact of hallucinations on the level of impairment in the visuospatial domain.

Method: Archival data obtained over three years from a total of 73 patients from the Health First Memory Disorder Clinic was used in this study. Participants were included in the study if they endorsed experiencing hallucinations, were given the VOT during their brief neuropsychological evaluation, and were diagnosed with dementia or unspecified neurocognitive disorder. The patient’s electronic medical record was used to retrospectively gather additional details regarding their hallucinations and …

Dysregulation Of Complement System In Neuropsychiatric Disorders: A Mini Review, Danny Perez Sierra, Ashutosh Tripathi, Anilkumar Pillai

Faculty, Staff and Student Publications

Complement system is one of the most important defense mechanisms of the innate immune system. In addition to their roles in immune regulation, complement proteins are also involved in neurodevelopment and adult brain plasticity. Complement dysregulation has been shown in neurodevelopmental disorders including schizophrenia and autism spectrum disorder as well as in mood disorders. A number of clinical as well as genetic studies suggest the role of complement proteins in the cortical thinning and excessive synaptic pruning frequently associated with schizophrenia. The changes in complement proteins are also associated with the pathophysiology of autism spectrum disorder, major depressive disorder and …

When Intelligence Hurts And Ignorance Is Bliss: Global Pandemic As An Evolutionarily Novel Threat To Happiness, Satoshi Kanazawa, Norman P. Li, Jose C. Yong

Research Collection School of Social Sciences

Introduction: The savanna theory of happiness posits that it is not only the current consequences of a given situation that affect happiness but also its ancestral consequences, and that the effect of ancestral consequences on happiness is stronger among less intelligent individuals. But what about situations that did not exist in the ancestral environment and thus have no ancestral consequences? Global pandemic is one such situation that has no ancestral analog, and the theory predicts such evolutionarily novel threats to have a negative effect disproportionately on the life satisfaction of more intelligent individuals.Methods: We analyzed prospectively longitudinal data from population …

The Effect Of Executive Function On The Development Of Chronic Pain: A Prospective Longitudinal Study, Wee Qin Ng, Andree Hartanto

Research Collection School of Social Sciences

Increasing evidence suggests a close association between chronic pain and executive function, a set of cognitive processes necessary for goal-directed behaviors. However, there is a dearth of longitudinal studies examining the predictive effect of executive function on the development of chronic pain. Drawing on the cyclical model of executive function and health, we sought to examine how executive function, measured at baseline, may predict chronic pain etiology approximately 9 years later. Using a large-scale dataset of midlife adults (N = 1553) from the MIDUS 2 and 3 (Midlife Development in the United States) studies, we employed multivariate logistic regression to …

Exploring Perceptions Of Control Within Offender Cognition And Recidivism Paradigms, Anistasha H. Lightning, Danielle Polage

Student Published Works

Elements of perceived control are associated with recidivism in offender populations. We investigated the application of locus of control to the frequency of personal involvement with the law and to beliefs surrounding the likelihood of future contact with the legal system. We hypothesized that, as the number of sentencings or legal experiences increased, locus of control would externalize. We also predicted that increased legal involvement would lead to greater belief in the likelihood of future involvement. A statistically significant path model suggests that locus of control appears to be a predictor of increased criminality, as opposed to the other way …

Hdac2 In Primary Sensory Neurons Constitutively Restrains Chronic Pain By Repressing Α2Δ-1 Expression And Associated Nmda Receptor Activity, Jixiang Zhang, Shao-Rui Chen, Meng-Hua Zhou, Daozhong Jin, Hong Chen, Li Wang, Ronald A Depinho, Hui-Lin Pan

Faculty, Staff and Student Publications

α2δ-1 (encoded by the Cacna2d1 gene) is a newly discovered NMDA receptor-interacting protein and is the therapeutic target of gabapentinoids (e.g., gabapentin and pregabalin) frequently used for treating patients with neuropathic pain. Nerve injury causes sustained α2δ-1 upregulation in the dorsal root ganglion (DRG), which promotes NMDA receptor synaptic trafficking and activation in the spinal dorsal horn, a hallmark of chronic neuropathic pain. However, little is known about how nerve injury initiates and maintains the high expression level of α2δ-1 to sustain chronic pain. Here, we show that nerve injury caused histone hyperacetylation and diminished enrichment of histone deacetylase-2 (HDAC2), …

Hiv And Early Life Stress On Neuroimaging And Risky Behavior, Paola Garcia Egan

Dissertations

This study examined the interactive effects of early life stress (ELS) and HIV on brain morphometry, diffusion-basis-spectrum-imaging (DBSI), risky decision-making, and sex-risk behavior. 122 people with HIV (PWH) and 113 people without HIV (PWoH), free of major psychiatric illness and neurological confounds, were stratified into high (≥ 3 events) vs. low (< 3 events) ELS [PWoH/low ELS (n = 57), PWoH/high ELS (n =56), PWH/low ELS (n = 43), PWH/high ELS (n = 79)] and underwent structural magnetic resonance imaging, DBSI, neuropsychological, and risky-behavior assessment; all PWH were virologically controlled. Compared to PWoH, PWH had smaller orbitofrontal cortex (OFC), parietal lobes, insula, caudate and anterior cingulate. No ELS effects were detected in volumetric measures. Significant interactions were found between HIV serostatus and ELS on the OFC and on cellularity of the inferior fronto-occipital fasciculus after multiple comparisons adjustment. Specifically, PWH/high ELS exhibited significantly smaller OFC and PWoH/high ELS show significantly larger OFC than the other groups. PWoH/high ELS exhibited higher DBSI cellularity (neuroinflammation proxy) of the inferior-occipital-fasciculus compared to PWoH/high ELS. Regardless of HIV status, executive function moderated the relationship between the OFC and sex-risk behavior such that individuals within the sample who performed above average on a measure of executive function and had a larger OFC reported fewer sex partners in past six months than individuals with smaller volumes. No interaction was found between HIV serostatus and ELS on risky behavior measures. Clustering analyses defined ELS subgroups in PWH that were determined by demographic characteristics, duration of infection, recent CD4+ T-cell count, nadir CD4+ T-cell count and high/low ELS.Even in PWH that are virologically controlled, without major current psychiatric comorbidities, there is evidence of a synergistic impact of ELS and HIV on OFC volumes. Higher volumes in the OFC were detrimental when associated with lower executive function scores or advantageous when associated with higher executive function. Findings suggest that ELS is associated with different brain signatures among PWoH and virally suppressed PWH. However, ELS was not directly associated with risky behaviors, and subgroups in PWH were characterized by demographic variables, past substance use and HIV clinical variables.

A Syndemic Perspective On Anti-Asian Racism And Asian American Mental Health During The Covid-19 Pandemic, Rebecca Mcgarity-Palmer

College of Science and Health Theses and Dissertations

Asian Americans have been negatively impacted by the COVID-19 pandemic, experiencing COVID-related anti-Asian racism as well as exacerbated pandemic-related stressors, such as increased negative mental health symptoms and economic challenges, due to existing structural inequities. Asian Americans are a diverse group made up of various ethnic and cultural groups with differential impacts from the pandemic. Examining differences within Asian Americans is therefore important to further understand the impacts of health inequities, economic challenges, and racism. Using a large, national dataset, I conducted three studies that examine Asian Americans’ experiences of anti-Asian racism, negative mental health symptoms, and economic challenges within …

How The Readability Level Of Prior Text Impacts Comprehension Of Subsequent Text, Benjamin Jerry Dumont

College of Science and Health Theses and Dissertations

The purpose of this thesis research is to explore how the difficulty of text impacts the ability to process subsequent text. The basic idea is that difficult text might deplete cognitive or attentional resources, creating difficulties for readers as they try to continue reading afterwards. A pilot study was conducted to gather preliminary data prior to the two final studies. High (easy to read) and low (difficult to read) readability passages were created and presented prior to a target passage. The results from the pilot study suggested that there may be differences in comprehension based on the readability and difficulty …

Cerebral Blood Flow And Cardiovascular Risk Effects On Resting Brain Regional Homogeneity, Bhim M Adhikari, L Elliot Hong, Zhiwei Zhao, Danny J J Wang, Paul M Thompson, Neda Jahanshad, Alyssa H Zhu, Stefan Holiga, Jessica A Turner, Theo G M Van Erp, Vince D Calhoun, Kathryn S Hatch, Heather Bruce, Stephanie M Hare, Joshua Chiappelli, Eric L Goldwaser, Mark D Kvarta, Yizhou Ma, Xiaoming Du, Thomas E Nichols, Alan R Shuldiner, Braxton D Mitchell, Juergen Dukart, Shuo Chen, Peter Kochunov

Faculty, Staff and Student Publications

Regional homogeneity (ReHo) is a measure of local functional brain connectivity that has been reported to be altered in a wide range of neuropsychiatric disorders. Computed from brain resting-state functional MRI time series, ReHo is also sensitive to fluctuations in cerebral blood flow (CBF) that in turn may be influenced by cerebrovascular health. We accessed cerebrovascular health with Framingham cardiovascular risk score (FCVRS). We hypothesize that ReHo signal may be influenced by regional CBF; and that these associations can be summarized as FCVRS→CBF→ReHo. We used three independent samples to test this hypothesis. A test-retest sample of N = 30 healthy …

Circadian Misalignment And Childhood Obesity: An Unexplored Target For Intervention And Treatment, Mason Pilling

Student Works

Childhood obesity is a pandemic affecting almost 40 million individuals aged 5-18 globally. Many current interventions are relatively successful at treating childhood obesity, yet the rate of childhood obesity continues to increase from year to year, and current intervention methods are struggling to keep up. Mounting evidence suggests that sleep may be a crucial mechanism for understanding and treating obesity, yet sleep still remains a relatively unexplored target for intervention. Circadian misalignment, a measure of the difference between the body’s preferred sleep timing and actual bed and wake times, has been almost completely ignored in the literature, despite preliminary findings …

To Feed Or Let Eat! A Scale Of Independence, Exploration, And Family To Measure Baby‐Led Weaning As A Complementary Feeding Approach, Emma Studer-Perez, Dara Musher-Eizenman

Psychology Faculty Publications

Background

This article reports the development and validation of a measure of parents' use of baby-led weaning (BLW). BLW is a child-centred approach to complementary feeding where the infant is allowed to eat whole foods (rather than purees) and explore a variety of foods and textures. To date, parents' use of BLW has been assessed using either single items or a wide variety of measures.

Method

In this study, exploratory and confirmatory factor analyses on independent samples supported three BLW subscales: independence, exploration, and family.

Results

The final 13-item scale showed adequate fit statistics and good reliability (χ2(62) = 115.02, …

Paired Housing Or A Socially-Paired Context Decreases Ethanol Conditioned Place Preference In Male Rats, Eva Lorenz, Chase Moye, Kah-Chung Leong

Psychology Faculty Research

Alcohol abuse dramatically affects individuals’ lives nationwide. The 2020 National Survey on Drug Use and Health (NSDUH) estimated that 10.2% of Americans suffer from alcohol use disorder. Although social support has been shown to aid in general addiction prevention and rehabilitation, the benefits of social support are not entirely understood. The present study sought to compare the benefits of social interaction on the conditioned ethanol approach behavior in rats through a conditioned place preference (CPP) paradigm in which a drug is paired with one of two distinct contexts. In experiment 1A, rats were single-housed and received conditioning trials in which …

Impact Of Adolescent Social Isolation On Adult, Binge-Like Ethanol Consumption And Plasma Corticosterone In High-Alcohol-Preferring Mice, Eva Cullins

The Journal of Purdue Undergraduate Research

Adolescent stress exposure increases the likelihood of alcohol misuse and alcohol use disorder (AUD) in adulthood; however, it is not clear how genetic and environmental factors interact to increase risk. This study examined how adolescent social isolation affects adult binge-like ethanol drinking and levels of the stress hormone corticosterone in male and female mice with a genetic predisposition toward high alcohol preference (HAP). Twenty-eight HAP mice were separated into group-housed (GH) and socially isolated (SI) conditions (n = 13, 13). Binge drinking was assessed using a drinking in the dark (DID) procedure. Blood samples were taken before DID and after …

Exploring Children’S Insights About Participating In Recreational Activities With Horses And Farm Animals: Social Emotional Experiences And Belief In Animal Mind, Christine Yvette Tardif-Williams, Renata P. S. Roma

People and Animals: The International Journal of Research and Practice

Research continues to shed light on the impact of children’s interactions with horses in equine-assisted, learning, and therapeutic contexts. However, we know relatively less about the impact of children’s recreational activities with horses and a diversity of farm animals. What is needed is research that explores how recreational programs involving activities with horses and farm animals are perceived by the child participants themselves. This pilot study sought to explore the insights of children who participated in a nine-week recreational program involving activities with horses and farm animals, with a focus on children’s social emotional experiences and belief in animal mind …

Introducing Interdisciplinary Curricula Into Conservation Biology: Exploring Changes In Students’ Perceived Proenvironmental Attitudes And Behaviors, Jasmine Janes, Lindsay J. Mccunn

Journal of Educational Research and Practice

Today, conserving the natural environment is paramount. Educators have been striving to develop pedagogical approaches that facilitate greater engagement in conservation behaviors. However, many of these reforms have been targeted at an institutional level, without necessarily testing whether changes in proenvironmental perceptions, attitudes, or behaviors occur for students. This step seems important when developing conservation biology courses that provide well-rounded education that may better prepare students for future challenges in biodiverse conservation contexts. Our objective was to assess the proenvironmental attitudes and conservation values of undergraduate students enrolled in an undergraduate conservation biology course before and after instruction to determine …

Note: Structured Psychometrics In Biglaw Talent Acquisition: Ai-Driven Quantitative Fit, Joseph J. Kim

Notre Dame Journal on Emerging Technologies

This Note combines a number of perspectives and disciplines to proffer a unique suggestion toward recognizing better talent and acquiring a new intraindustry competitive edge.

The Links Between Young Children’S Use Of Pacifiers And Swaddling With Child Sleep Arousal, Kenzie Goldsmith, Melanie Dubois

Undergraduate Psychology Research Methods Journal

Sleep arousal, or waking experiences during sleep, in young children was examined in relation to pacifier usage and the caregiver’s use of the swaddling technique. Primary caregivers of young children from 1 to 24 months old, fluent in English, and 18 years or older completed a Qualtrics survey detailing their child’s sleep routines. The survey questions considered the child’s use of self-soothing devices and the caregiver’s use of soothing techniques, namely pacifiers and swaddling. By utilizing the Brief Infant Sleep Questionnaire-Revised (BISQ-R; Sadeh et al., 2020), we examined the relationship between child sleep arousal and pacifier usage, along with sleep …

Using Behavior Skills Training To Promote Self-Advocating Behaviors: A Single Subject Research Design To Examine The Effectiveness Of Behavior Interventions Among Teachers, Clarence Cooper

Theses and Dissertations

Using Behavioral Skills Training to Promote Self-Advocating Behaviors: A Single-Subject Research Design to Examine the Effectiveness of Behavior Interventions Among Teachers. Clarence Cooper, 2022: Applied Dissertation, Nova Southeastern University, Abraham S. Fischler College of Education and School of Criminal Justice. Keywords: applied behavior analysis, behavioral skills training, inclusion, individual education plan, operant conditioning, prompting, reinforcer, self-advocacy, accommodation

This applied dissertation utilized the behavioral skills training to train teachers on how to prompt, identify, and reinforce self-advocacy behaviors among students with learning disabilities. In applying behavioral analytic interventions to strengthen desired outcomes, a one- day intervention that was grounded in a …

Deliberate Errors Promote Meaningful Learning, Sarah Shi Hui Wong, Stephen Wee Hun Lim

Research Collection School of Social Sciences

Our civilization recognizes that errors can be valuable learning opportunities, but for decades, they have widely been avoided or, at best, allowed to occur as serendipitous accidents. The present research tested whether greater learning success could paradoxically be achieved through making errors by intentional design, relative to traditional errorless learning methods. We show that deliberately committing and correcting errors even when one knows the correct answers enhances learning—a counterintuitive phenomenon that we termed the derring effect. Across two experiments (N = 160), learners engaged in open-book study of scientific expository texts and were then tested on their retention and higher-order …

Investigating The Relational Element Of Trust In Teacher-Principal Relationships: An Autoethnographic Case Study, Angela Bradley

LSU Doctoral Dissertations

This autoethnographic case study was designed to investigate the relational aspect of trust, a characteristic of servant leadership, in the teacher-principal relationship. This trusting bond is an often overlooked, foundational element of a school’s success. I examined the role that trust plays in enhancing a school’s culture and how trust is established and maintained among one principal and teachers under my supervision. In addition, as researcher, I sought to uncover specific indicators that trust was present on a school campus. Finally, I sought to examine trust’s effects on collaboration and organizational commitment.

Through weekly reflections, I sought to examine my …

Terminal Field Volume Of The Glossopharyngeal Nerve In Adult Rats Reverts To Prepruning Size Following Microglia Depletion With Plx5622, Andrew J. Riquier, Suzanne I. Sollars

Psychology Faculty Publications

Programmed reduction of synapses is a hallmark of the developing brain, with sensory systems emerging as useful models with which to study this pruning. The central projections (terminal field) of the gustatory glossopharyngeal nerve (GL) of the rat are a prime example of developmental pruning, undergoing an approximate 66% reduction in volume from postnatal day 15 (P15) to P25. Later in adulthood, developmental GL pruning can be experimentally reversed, expanding to preweaning volumes, suggesting mature volumes may be actively maintained throughout the life span. Microglia are central nervous system glia cells that perform pruning and maintenance functions in other sensory …

Undergraduate Perceptions Of Warmth And Competence Across Academic Professions, Porsha Nichole Neal Mcgregor

Student Theses and Dissertations

The Stereotype Content Model (SCM; Fiske et al., 2002) is utilized to make sense of how individuals and groups assess others. The SCM consist of to two basic dimensions: perceived warmth and competence. Little research has been conducted to analyze how people perceive individuals in relation to their professional roles. To better understand potential stereotypes of professions, participants were asked to rate general professions on the two dimensions of warmth and competence. Results from the study supported some patterns found in previous research by Brambillia et al. (2010) in regards to two professions and indicated similarities in newly studied professions.

Who Fears Strangers And Spiders: Political Ideology And Feeling Threatened, Thomas Lukaszewicz

Honors Program: Senior Projects (Public)

In this study, I evaluated the correlations between threat sensitivities and political ideology. Two hypotheses were tested. First, I hypothesized that conservatives would have higher social threat sensitivity than liberals, with social threat defined as a threat dependent on outgroup or social actions (Barclay & Benard, 2020). Second, I hypothesized that conservatives would have higher disgust sensitivity than liberals. To test these and related hypotheses I used a 2018 Qualtrics national demographically representative sample that included 1031 participants. To operationalize threat sensitivity, I used items asking participants to rate how threatened they felt by various fears. These individual items were …

Early Life Exposure To Unpredictable Parental Sensory Signals Shapes Cognitive Development Across Three Species, Elyssia Poggi Davis, Kari Mccormack, Hina Arora, Desiree Sharpe, Annabel K. Short, Jocelyne Bachevalier, Laura M. Glynn, Curt A. Sandman, Hal S. Stern, Mar Sanchez, Tallie Z. Baram

Psychology Faculty Articles and Research

Exposure to early life adversity has long term consequences on cognitive function. Most research has focused on understanding components of early life adversities that contribute to later risk, including poverty, trauma, maltreatment, and neglect. Whereas these factors, in the aggregate, explain a significant proportion of emotional and cognitive problems, there are serious gaps in our ability to identify potential mechanisms by which early life adversities might promote vulnerability or resilience. Here we discuss early life exposure to unpredictable signals from the caretaker as an understudied type of adversity that is amenable to prevention and intervention. We employ a translational approach …

Contrafreeloading In Kea (Nestor Notabilis) In Comparison To Grey Parrots (Psittacus Erithacus), Gabriella E. Smith, Amalia P. M. Bastos, Martin Chodorow, Alex H. Taylor, Irene M. Pepperberg

Publications and Research

Contrafreeloading—working to access food that could be freely obtained—is rarely exhibited and poorly understood. Based on data from Grey parrots ( Psittacus erithacus ), researchers proposed a correlation between contrafreeloading and play: that contrafreeloading is more likely when subjects view the task as play. We tested that hypothesis by subjecting a relatively more playful parrot species, the kea ( Nestor notabilis ), to the same experimental tasks. Experiment 1 presented eight kea with container pairs holding more- or less-preferred free or enclosed food items, and examined three types of contrafreeloading: calculated (working to access preferred food over less-preferred, freely available …

Dsm Discrimination And The Lgbt Community: Using The History Of Diagnostic Discrimination Against Sexual Minorities To Contextualize Current Issues In Transgender And Gender Diverse Mental Healthcare, Ginelle Wolfe, Nicole Fogwell

Psychology from the Margins

This paper provides a historical context of diagnoses in the Diagnostic and Statistical Manual of Mental Disorders (DSM) related to sexual orientation and gender identity. We use the historical context of psychology’s discrimination against sexual minorities (e.g., lesbian, gay, and bisexual persons) to critique current discriminatory practices targeting gender diverse (i.e., trans, nonbinary, and other not cisgender) persons- specifically, the explicit pathologizing of gender variance. The events that led to the removal of homosexuality as a diagnosis are discussed, as are subsequent diagnoses related to sexual orientation and gender identity that continue to pathologize gender variance. We conclude by deriving …

Cue-Induced Cocaine Craving Enhances Psychosocial Stress And Vice Versa In Chronic Cocaine Users, Ann-Kathrin Kexel, Bruno Kluwe-Schiavon, Markus R Baumgartner, Etna J E Engeli, Monika Visentini, Clemens Kirschbaum, Erich Seifritz, Beate Ditzen, Leila M Soravia, Boris B Quednow

Faculty, Staff and Student Publications

Stress and craving, it has been found, contribute to the development and maintenance of and relapse in cocaine use disorder. Chronic cocaine users (CU), previous research has shown, display altered physiological responses to psychosocial stress and increased vegetative responding to substance-related cues. However, how psychosocial stress and cue-induced craving interact in relation to the CU's physiological responses remains largely unknown. We thus investigated the interaction between acute psychosocial stress and cocaine-cue-related reactivity in 47 CU and 38 controls. In a crossed and balanced design, the participants were randomly exposed to a video-based cocaine-cue paradigm and the Trier Social Stress Test …

The Impact Of Cannabis On Motivational Processes For Smoked Tobacco And Cigarettes, Claire M. Gorey

USF Tampa Graduate Theses and Dissertations

Cannabis and tobacco are very commonly used across the United States. Given the high prevalence of their dual use, an important health consequence of cannabis is its impact on tobacco usage rates. After all, cigarettes are a leading cause of death in the United States. Theoretical models of drug abuse suggest that cannabis cues and intoxication may be responsible for enhanced smoked tobacco/cigarette motivation. Therefore, the present research sought to assess these routes via two studies. In study 1 (validation & cross-drug cue effects), researchers validated a set of realistic cannabis images among a sample of participants residing in the …

Molecular Pathways Of Major Depressive Disorder Converge On The Synapse, Gabriel R Fries, Valeria A Saldana, Johannes Finnstein, Theo Rein

Faculty, Staff and Student Publications

Major depressive disorder (MDD) is a psychiatric disease of still poorly understood molecular etiology. Extensive studies at different molecular levels point to a high complexity of numerous interrelated pathways as the underpinnings of depression. Major systems under consideration include monoamines, stress, neurotrophins and neurogenesis, excitatory and inhibitory neurotransmission, mitochondrial dysfunction, (epi)genetics, inflammation, the opioid system, myelination, and the gut-brain axis, among others. This review aims at illustrating how these multiple signaling pathways and systems may interact to provide a more comprehensive view of MDD's neurobiology. In particular, considering the pattern of synaptic activity as the closest physical representation of mood, …