Digital Commons Network^™

Activation Of Cell-Free Mtdna-Tlr9 Signaling Mediates Chronic Stress-Induced Social Behavior Deficits, Ashutosh Tripathi, Alona Bartosh, Carl Whitehead, Anilkumar Pillai

Faculty, Staff and Student Publications

Inflammation and social behavior deficits are associated with a number of neuropsychiatric disorders. Chronic stress, a major risk factor for depression and other mental health conditions is known to increase inflammatory responses and social behavior impairments. Disturbances in mitochondria function have been found in chronic stress conditions, however the mechanisms that link mitochondrial dysfunction to stress-induced social behavior deficits are not well understood. In this study, we found that chronic restraint stress (RS) induces significant increases in serum cell-free mitochondrial DNA (cf-mtDNA) levels in mice, and systemic Deoxyribonuclease I (DNase I) treatment attenuated RS-induced social behavioral deficits. Our findings revealed …

Not Getting Laid: Consumer Acceptance Of Precision Fermentation Made Egg, Oscar Z. Thomas, Mark Chong, Angela K. Y. Leung, Tricia M. Fernandex, Shu Tian Ng

Research Collection Lee Kong Chian School Of Business

Mounting concern over the negative externalities of industrialized animal agriculture, coupled with falling cost curves of novel food technologies have birthed the field of cellular agriculture: a new category of food technology seeking to reproduce the sensory experiences of animal protein, and promising a cleaner, more ethical way of enjoying animal proteins. This research examines consumer acceptance of precision fermentation (PF) made egg products in Germany, Singapore, and the USA. Using an online survey of 3,006 participants, the study examines demographic and dietary traits that predict willingness to try such products and identifies the reasons why consumers are most attracted …

Introduction: Exploring The Various Dimensions And Manifestations Of Solidarity, Ronald Pagnucco

The Journal of Social Encounters

No abstract provided.

New Perspectives: How A Dancefloor Of Paradigms Can Save The World, Gill R. Hall

Journal of Conscious Evolution

This paper explores how the consciousness of Indigenous peoples can facilitate the development of new paradigms to address global issues like climate change and adaptation to global warming. It explores how Indigenous and Western notions of consciousness differ and cannot be reconciled in contemporary models of consciousness without colonising Indigenous ways of knowing. It differentiates maternal and patriarchal consciousnesses and contrasts the body/heart pathway found in many Indigenous cultures with the mental field activity of the Western psyche. Using the concept of a multi-paradigmatic dancefloor, I propose a new model for developing global thinking on complex problems, inviting academics and …

Examining Drinking To Cope During The Covid-19 Pandemic As Reinforcement Pathology, Matthew Dwyer

Theses and Dissertations

The COVID-19 pandemic is the largest global public health challenge of this century. Concerns were raised that the rapid changes associated with daily life during the initial months of the pandemic would increase depression and alcohol use. However, changes in population-level alcohol use have been mixed. Behavioral economic theories of addiction, such as the Reinforcer Pathology (RP) model, have been proposed as well suited to identify individuals, and inform interventions, to address these concerns. However, no quantitative research has validated this claim in a sample recruited during the pandemic. The current study extended upon existing research by examining patterns of …

Oleoylethanolamide Facilitates Pparα And Tfeb Signaling And Attenuates Aβ Pathology In A Mouse Model Of Alzheimer’S Disease, Michele M Comerota, Manasee Gedam, Wen Xiong, Feng Jin, Lisheng Deng, Meng C Wang, Jin Wang, Hui Zheng

Faculty, Staff and Students Publications

BACKGROUND: Age is the strongest risk factor for the development of Alzheimer's disease (AD). Besides the pathological hallmarks of β-amyloid (Aβ) plaques and neurofibrillary tangles, emerging evidence demonstrates a critical role of microglia and neuroinflammation in AD pathogenesis. Oleoylethanolamide (OEA) is an endogenous lipid amide that has been shown to promote lifespan and healthspan in C. elegans through regulation of lysosome-to-nucleus signaling and cellular metabolism. The goal of our study was to determine the role of OEA in the mediation of microglial activity and AD pathology using its stable analog, KDS-5104.

METHODS: We used primary microglial cultures and genetic and …

The S9 Model: A Comprehensive Framework For Conceptualizing Student Suicidality, Katherine C. Wilson

Dissertations, 2020-current

This dissertation introduces the S9 Model of Suicidality, an innovative framework for conceptualizing and understanding suicidality among college students. The S9 Model integrates biological, psychological, ecological, and sociocultural dimensions of suicidality into a comprehensive approach to help inform prevention, intervention, and postvention on college campuses. Drawing from empirical research, the history of suicidology, relevant psychological theories, and insights from mental health practitioners, this model encapsulates a holistic view of suicidality, considering key factors like genetic predispositions, neurobiological processes, cognitive function, psychosocial stressors, cultural norms, societal expectations, and broader ecological contexts.

The model’s tripartite approach, focusing on the ontological, ecological, and …

Nmda Receptor Inhibition On Rodent Optimal Decision-Making In The Diminishing Returns Task, Seth Foust

Research Psychology Theses

There has been growing interest in using N-methyl-D-aspartate (NMDA) receptor antagonists as treatments for mood disorders, but there is still much to learn about their cognitive effects. Research shows NMDA receptors can affect decision-making, and the antagonist MK-801 has had varying effects in rodents. Specifically, some have reported impairments in working memory while foraging behaviors remained intact, while others have demonstrated changes in choice behavior related to delay or risk in behavior tasks. We investigated the role of NMDA receptors in the specific paradigm of optimal decision-making to further confirm MK-801’s effects and to explore whether inhibiting NMDA receptors alters …

Sex Differences In Metabolic Phenotype And Hypothalamic Inflammation In The 3xtg-Ad Mouse Model Of Alzheimer's Disease., Lisa S. Robison, Olivia J. Gannon, Abigail E. Salinero, Charly Abi-Ghanem, Richard D. Kelly, David A. Riccio, Febronia M. Mansour, Kristen L. Zuloaga

Faculty Articles

BACKGROUND: Alzheimer's disease (AD) is notably associated with cognitive decline resulting from impaired function of hippocampal and cortical areas; however, several other domains and corresponding brain regions are affected. One such brain region is the hypothalamus, shown to atrophy and develop amyloid and tau pathology in AD patients. The hypothalamus controls several functions necessary for survival, including energy and glucose homeostasis. Changes in appetite and body weight are common in AD, often seen several years prior to the onset of cognitive symptoms. Therefore, altered metabolic processes may serve as a biomarker for AD, as well as a target for treatment, …

Terror Management And The News: An Exploration Into The Effects Of Framing On Mortality Salience, Peter Montwill

Masters Theses, 2020-current

The present study explores the link between Terror Management Theory and the use of its principles within news media. Political news media in the digital age undergoes a variety of framing effects, more specifically episodic and thematic frames of stories. To induce mortality salience, college-aged participants were presented with stories framed from the perspective of an individual’s experience or a general theme of experiences regarding the controversial pro-life topic and a non-controversial hiking topic. These stories are presented in the style of Instagram posts to mirror how college-aged people consume news media. The stories also contain wording designed to induce …

Is A Test The Best?, Giulia Ronnette Mcdonald

Theses and Dissertations

The test effect (Roediger & Karpicke, 2006) demonstrates that performance on a final test is better when an immediate test is taken after reading a passage rather than rereading. Although transfer appropriate processing has been suggested as a theoretical explanation, the results could be due to elaborative retrieval processes during the immediate test that are not available during restudy. We compared testing to three other strategies using elaborative retrieval—Generating Questions, Read-Recite-Review, Teaching—to determine whether they would be as beneficial as testing. Results showed that each of the alternative strategies produced final test performance equal to that of testing, suggesting not …

Dog Tired: Examining The Relation Between Dog And/Or Cat Ownership And Owners’ Sleep, Courtney J. Bolstad

Theses and Dissertations

Sleep is an essential part of life, and obtaining quality sleep is important for various areas of functioning. Behaviors to promote sleep include physical activity, managing stress, reducing anxiety symptoms, maintaining a consistent sleep schedule, and obtaining bright light exposure. Many of these behaviors overlap with benefits observed from pet ownership (PO). The present study aimed to examine the relation between PO and sleep as well as moderators and mediators of this relation. Four research questions were examined: 1) Is PO significantly related to sleep? 2) Does gender moderate the relation between PO and sleep? 3) Do sleep-promoting behaviors (i.e., …

The Effects Of Transcranial Direct Current Stimulation (Tdcs) On Facial Expression Approach/Avoidance In College Students And Faculty With Broad Autism Phenotype, Nicole R. Baker

Electronic Theses and Dissertations

Transcranial Direct Current Stimulation (tDCS) has been proposed as an alternative noninvasive therapy for individuals with autism. This study trained brain activity in college students and / or faculty with Broad Autism Phenotype (BAP) while eye tracking data was collected. The purpose of this study was to determine if tDCS training to the frontal lobes could increase approach toward social interactions in adults classified as BAP as demonstrated by eye-tracking measures in response to faces and gaze fixation. The study included 21 total participants recruited from the Science, Technology, Engineering, and Math (STEM) courses / professions at a Regional East …

Using Motivation To Assess Affective States Of Captive Red Kangaroos (Macropus Rufus) In Response To Visitor Presence And Crowd Size In A Walk-Through Zoo Exhibit, Julia King

Theses and Dissertations

This study investigates how visitor presence influences affective states of captive red kangaroos housed in a walk-through zoo exhibit by using motivation to consume a food reward in desired vs undesired locations and with/without an additional challenge feeder as a proxy for affective state, while considering individual variation and personality.

Age And Sex Of Wild Asian Elephants Observed In And Around Protected Areas In Kanchanaburi, Thailand, Leah D. Wersebe

Theses and Dissertations

This study observed the wild Asian elephant population in and around Salakpra Wildlife Sanctuary and found a greater proportional presence of adults and subadults than calves and infants per observation, and a greater proportion of males than females outside of the protected area compared to inside the protected area.

Seasonal Crop Foraging Habits Of Asian Elephants And The Response Of Farmers Near The Salakpra Wildlife Sanctuary, Kanchanaburi, Thailand, Scott J. Gulizio

Theses and Dissertations

The consequences of human-elephant-conflict are of concern to a range of interests, including conservation, animal welfare, and socio-economic initiatives. Loss of crops due to elephants is a particularly contentious issue and a multitude of elephant deterrents have been tried to help prevent or diminish crop-foraging. This study examines the seasonal crop-foraging habits of Asian elephants just outside of Salakpra Wildlife Sanctuary, Thailand. Specifically, we sought to analyze when the elephants would forage crops, for how long, and how farmer presence affected this behavior. Additionally, to better understand patterns of deterrent use, we cataloged which deterrents were deployed by the farmers …

Csf1r Regulates Schizophrenia-Related Stress Response And Vascular Association Of Microglia/Macrophages, Ling Yan, Yanli Li, Fengmei Fan, Mengzhuang Gou, Fangling Xuan, Wei Feng, Keerthana Chithanathan, Wei Li, Junchao Huang, Hongna Li, Wenjin Chen, Baopeng Tian, Zhiren Wang, Shuping Tan, Alexander Zharkovsky, L Elliot Hong, Yunlong Tan, Li Tian

Faculty, Staff and Student Publications

BACKGROUND: Microglia are known to regulate stress and anxiety in both humans and animal models. Psychosocial stress is the most common risk factor for the development of schizophrenia. However, how microglia/brain macrophages contribute to schizophrenia is not well established. We hypothesized that effector molecules expressed in microglia/macrophages were involved in schizophrenia via regulating stress susceptibility.

METHODS: We recruited a cohort of first episode schizophrenia (FES) patients (n = 51) and age- and sex-paired healthy controls (HCs) (n = 46) with evaluated stress perception. We performed blood RNA-sequencing (RNA-seq) and brain magnetic resonance imaging, and measured plasma level of colony stimulating …

The Words. Or Holes. Or Both: Writing As An Integrative Methodology For Trauma, Daniel A. Castle

Electronic Theses and Dissertations

This project seeks to identify methods authors have used to integrate their traumatic experiences. My work will analyze the genre of War Literature and specific authors like J.R.R. Tolkien and Kurt Vonnegut to explore the way writers describe the trauma of combat. Using insights from neuroscience and psychology, I will expand the field of Cognitive Literary Studies from a focus on the reader to a focus on the writer by linking neurological functions with narrative tools.

The Relationship Between Poverty And Behavior Problems : Examining The Role Of Family And Parental Factors From An Ecological Systems Perspective, Alaina Marie Wodzinski

Theses, Dissertations and Culminating Projects

The large number of children from low-income households or living in poverty are at increased risk for a range of negative outcomes, including behavior problems. The Family Stress Model is a framework that can be used to describe how poverty may shape the development of behavior problems through its influence on family processes, including parental mental health, parenting, and household environment. While the Family Stress Model has been widely replicated, studies have rarely examined the context of infancy and toddlerhood, during which family-related processes tend to be more impactful in child development. Therefore, the present study evaluated two adaptations of …

Underneath It All: Uncanny Sounds, The Materiality Of The City Through The Ear Of The Other, Patrick Fuery

CCI Articles and Research

"One of the intricate connections that shapes urban spaces is made through the interweaving of divergent, competing, and complimenting sounds. Just as objects, inhabitants, and histories form urban spaces, there is also an aurality that defines each one, distinguishing it from all others. The flows and ripples of these different soundscapes simultaneously challenge the separations of urban spaces and reinforce the distinctions. At the most overt, these are the sounds of the market as they exceed the spatial boundaries and mix with traffic noises; the softer sounds of the park that muffle and hold construction clamor; the multicultural voices as …

Voluntary Action And Conscious Intention, Jake Gavenas

Computational and Data Sciences (PhD) Dissertations

Traditional experimental methodology in neuroscience involves comparing responses to different stimuli to make inferences about the human brain. However, human volition entails making decisions and acting in a manner that is underdetermined by the external environment. Investigations of the neuronal basis of volition have led to new controversies regarding the existence of free will, and offer potential directions for medical treatments of disorders such as addiction, akinetic mutism, and locked-in syndrome. However, because volition experiments leave aspects of responses “up to” participants, neuroscientists must utilize computational techniques such as modeling, simulation, and advanced analyses to progress our understanding of human …

Reflections On Panpsychism, Pantheism, Panentheism And The Hard Problem Of Consciousness, Barbara Engelhardt

Journal of Conscious Evolution

This article discusses the concepts of panpsychism, pantheism, and panentheism with the intention of formulating a theory and response to what is referred to as the Hard Problem of Consciousness, the question put forth in the latter 20th century by the philosopher David Chalmers (and by many others historically) concerning why and how we have phenomenal experiences. Panpsychism is the view that the ubiquitous presence of consciousness is an elemental principium of the natural world. Pantheism is defined as a philosophy which equates divinity with all reality. Panentheism asserts that God is intrinsic in all things in the known universe, …

Evolution Of Women’S Consciousness: Toward Integral Consciousness, Katherine T. Ziemke

Journal of Conscious Evolution

This article presents research materials which demonstrate historical consciousness for women of ancient European descent, the cultural heritage of the author. Awareness is examined from various historical angles in a transdisciplinary approach to the work. I explore the possibility that women’s historical and continued oppression may be a sign of the disintegration of the mental and a re-emergence of the integral structure of consciousness. A broad examination of women’s historical roles and corresponding thought shows how ancient consciousness may be used to accelerate a path toward integral consciousness today. Finally, this essay proposes that women’s historical consciousness and primordial memories …

All Hands On Deck: Choosing Virtual End Effector Representations To Improve Near Field Object Manipulation Interactions In Extended Reality, Roshan Venkatakrishnan

All Dissertations

Extended reality, or "XR", is the adopted umbrella term that is heavily gaining traction to collectively describe Virtual reality (VR), Augmented reality (AR), and Mixed reality (MR) technologies. Together, these technologies extend the reality that we experience either by creating a fully immersive experience like in VR or by blending in the virtual and "real" worlds like in AR and MR.

The sustained success of XR in the workplace largely hinges on its ability to facilitate efficient user interactions. Similar to interacting with objects in the real world, users in XR typically interact with virtual integrants like objects, menus, windows, …

The Effects Of Primary And Secondary Task Workloads On Cybersickness In Immersive Virtual Active Exploration Experiences, Rohith Venkatakrishnan

All Dissertations

Virtual reality (VR) technology promises to transform humanity. The technology enables users to explore and interact with computer-generated environments that can be simulated to approximate or deviate from reality. This creates an endless number of ways to propitiously apply the technology in our lives. It follows that large technological conglomerates are pushing for the widespread adoption of VR, financing the creation of the Metaverse - a hypothetical representation of the next iteration of the internet.

Even with VR technology's continuous growth, its widespread adoption remains long overdue. This can largely be attributed to an affliction called cybersickness, an analog to …

Components Of Emotional Functioning Among People With Substance Use And Posttraumatic Stress Difficulties: An Idiographic Perspective, Danielle Higuera

Graduate Theses and Dissertations

Prior research has examined components of emotional functioning (e.g., clarity, physiological sensations, expression, regulation) among people with substance use and/or posttraumatic stress at the group level; however, a more cohesive/comprehensive understanding of how these factors unfold and connect for individual people who comprise these populations is needed. The current study used a qualitative interview design to explore the emotional worlds of participants (N = 44) who comprised four groups (substance use [n ¬= 11], posttraumatic stress [n = 12], co-occurring substance use and posttraumatic stress [n = 11], and healthy controls [n = 10]) to gain a person-level understanding of …

A Review Of The Role Of Anxiety In Diagnosis Of Children And Adolescents With Autism Spectrum Disorder: A Paradigm Shift In Conceptualization And Diagnosis, Evan Wahlquist

Dissertations

Early evidence of co-occurring anxiety symptoms in children and adolescents with autism spectrum disorder (ASD) dates back to the first descriptions of ASD by Leo Kanner (1943) and Hans Asperger (Frith & Mira, 1992). While current research has identified anxiety disorders as one of the most prevalent co-occurring disorders in children and adolescents with ASD, little is known about the nature of the relationship between these disorders. In an effort to explain these high prevalence rates, recent research has started to investigate the relationship between these two disorders. To join these efforts, this clinical research project explored the role of …

A Thematic Analysis Exploring The Narratives Of Growing Up As A Second-Generation Survivor Of The 1994 Genocide Against The Tutsi In Rwanda And The Presence Of Generative Commitment, Victor Mpore

Department of Agricultural Leadership, Education, and Communication: Dissertations, Theses, and Student Research

The scientific analysis of narratives from survivors of a genocide like the 1994 genocide against the Tutsi has provided an understanding on the survivors experiences during and after the genocide. Most narrative research on the 1994 genocide against the Tutsi has however primarily focused on the survivors and not their children. This study focuses on the second-generation survivors as a significant portion of the Rwandan population was born after the genocide. Drawing on the narrative approach, this study thematically analyzed narratives the second-generation survivors of the 1994 genocide against the Tutsi have about: a) their childhood and young adulthood in …

The Lived Experiences Of 911 Dispatchers With Compassion Fatigue: An Interpretive Phenomenology, Angela Johnson

Counseling & Human Services Theses & Dissertations

911 dispatchers are the “first” first responders in an emergency and play an intrinsic role in the public safety continuum. 911 dispatchers are exposed to daily and cumulative stress from the repeated empathic engagement of those they serve, and from shift work, staffing shortages, and inability to make mistakes. However, there is a dearth of peer reviewed literature on 911 dispatchers and compassion fatigue (CF). CF is described as the emotional and physical exhaustion experienced due to the constant exposure to the trauma of others. CF symptomology in 911 dispatchers has far reaching implications for not only the citizens …

Examination Of Performance Validity And The Relationship To Cognition And Symptoms In Schizophrenia Spectrum Disorders, Erick A. Rogers

UNLV Theses, Dissertations, Professional Papers, and Capstones

Approximately one-in-five individuals with psychotic disorders (i.e., schizophrenia spectrum disorders [SSD]) fail performance validity indicators (PVIs) during neurocognitive testing. Ensuring the validity of neurocognitive test results is necessary if the test scores are to be of use for diagnostic consideration, intervention selection and planning, predicting outcomes, and following changes in cognition over time in response to intervention, spontaneous recovery, or disease progression. PVIs are designed to require only a minimum level of engagement with the evaluation, which means nearly everyone is expected to “pass,” even those with moderate to severe brain damage. Traditional interpretations of PVI failure suggest a noncredible …