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Amp-Activated Protein Kinase Kinase Activity And Phosphorylation Of Amp-Activated Protein Kinase In Contracting Muscle Of Sedentary And Endurance Trained Rats, Denise Hurst

Theses and Dissertations

This study was designed to examine activity of AMP-activated protein kinase kinase (AMPKK) and AMP-activated protein kinase (AMPK) in muscles from control (C) and endurance trained (T) rats. Rats were trained 5 days/wk, 2 hr/d for 8 wks at a final intensity of 32 m/min up a 15% grade with 30 second sprints at 52 m/min every 10 min. Gastrocnemius muscles were stimulated in situ in T and C rats for 5 min at frequencies of 0.4/sec and 1/sec. Gastrocnemius LKB1 protein, a putative component of the AMPKK complex (LKB1, STRAD, and MO25), increased approximately 2-fold in response to training. …

Construction Of A Col11a1 Transgene Vector, Cameron Mckell Beck

Theses and Dissertations

Background: Cartilage disorders affect millions of people in the United States alone, with effects ranging from poor skeletal development and joint pain to shortened lifespan and perinatal lethality. Many of these disorders have their root in defects of collagen, type XI collagen being among the most important. A mouse model of such a type XI collagen defect is the chondrodysplasia (cho) mutant. Mice homozygous for this null mutation in the Col11a1 gene do not express the α1 chain of type XI collagen. This results in a functional knockout of type XI collagen, leading to insufficient skeletal development and perinatal lethality. …

Molecular Analysis Of The Effects Of Atrazine On Xenopus Laevis Frogs, Ronald Edward Celestine

Dissertations

Atrazine, the most commonly used herbicide in the U.S., has been implicated as one of the factors that may be causing the worldwide decline of amphibians. First, I examined effects of atrazine on laboratory raised Xenopus laevis tadpoles, treated from 5 days post fertilization to NF stage 65/66 with a concentrationof 25 ppb of atrazine. This study showed no significant difference in body weight, length and metamorphic rate.

Second, I used DNA microarrays to examine mRNA expression levels of genes in atrazine treated and control Xenopus laevis tadpoles. I found significant changes in gene expression levels of 18 genes. These …

Synthesising Life-Sciences And Control Engineering: An Outline Survey And A Practical Example, Aidan O'Dwyer

Conference papers

There is an increasing interest in life science related areas in the electrical and control engineering community [1]. One manifestation of this interest is the development of interdisciplinary programmes, such as the B.Sc. in Medical Physics and Bioengineering, offered by the Dublin Institute of Technology from September 2005. A significant amount of research work in control engineering has focused on aspects of human physiological system, for example blood glucose regulation [2], cardiovascular modelling and control [3], and limb control [4]. There is an increasing emphasis on interdisciplinary research; in recognition of this, the Institute of Electrical Engineers (IEE) has starting …

Medical Technology: Contexts And Content In Science And Technology, Michael A. De Miranda, Mark Doggett, Jane T. Evans

Architectural and Manufacturing Sciences Faculty Publications

No abstract provided.

Implementation And Validation Of A Real-Time Wireless Non-Invasive Physiological Monitoring In A High-G Environment, H. Aydin Akcivi

Theses and Dissertations

The overall purpose of this research is to develop a system capable of real-time personal positioning and physiological monitoring. The system will be composed of a shirt having non-invasive physiological sensors, Global Positioning System (GPS) receiver, wireless data transceiver, and real-time PC-based control station. The specific purpose of this research phase was to determine the performance capabilities of a modified LifeShirt™ alone (without GPS) in a high gravitational force environment with the data being sent wirelessly in real-time. The LifeShirt™ was modified with a real time wireless transmission system.

The Impact Of Burnout On Human Physiology And On Operational Performance: A Prospective Study Of Soldiers Enrolled In The Combat Diver Qualification Course, Charles A. Morgan Iii, Tracey Cho, Gary Hazlett, Vladimir Coric, Jeff Morgan

National Security Faculty Publications

(from p. 201) "If little is known about the pathophysiology of burnout, even less is known about the actual impact of burnout on military operational performance. This is due to a lack of studies focused on military performance. Whether or not soldiers may feel symptoms of burnout is one thing - whether this state actually affects how they do their job is another. Within the current environment (reduced forces, increased training rates, increased deployment rates, extended tours) we believe that military personnel may be at significant risk for the development of burnout. Further, we wondered if there was a demonstrable …

Long Chain Fatty Acids And Pc12 Cell Death, Joel E. Ulloth

Loma Linda University Electronic Theses, Dissertations & Projects

Hypoxic-ischemic and traumatic injury to the central nervous system (CNS) are major sources of morbidity and mortality. The broad goal of this dissertation research is to gain a better understanding of the cascade of injury events that follow hypoxic-ischemic and traumatic injury and how they may contribute to the cell death. To accomplish this goal, one of the major secondary events common to both traumatic and hypoxic-ischemic injury was investigated: the prolonged hydrolysis of membrane phospholipid with the release of massive quantities of free (non-esterified) fatty acid (FFA). The central hypothesis of this dissertation research is that elevated levels of …

The Affect Of Low Intensity, Progressive, Aerobic Exercise Training On Cardiovascular Function In The Diabetic Rat, Steven Michael Bauer

Morehead State Theses and Dissertations

A thesis presented to the faculty of the College of Science and Technology at Morehead State University in partial fulfillment of the requirements for the Degree of Masters of Science in Biology by Steven Michael Bauer on August 4, 2000.

First Principles Of Physio-Informatic Systems: Neurocosmology, David Jay Warner

Loma Linda University Electronic Theses, Dissertations & Projects

Physio-informatics is a new systems model for linking human physiologic systems to information systems in the most general way. Physio-informatics is used here to denote a systems based, physiologically robust reference architecture for designing and refining interactive human-computer interface systems in ways that increase operational throughput of information. In this dissertation, a systems model for interactive human-computer interface systems is developed. This model is a physiologically based reference architecture for designing and developing interactive human computer interface systems to match the human nervous system’s ability to transduce, transmit, and render to consciousness the necessary information to interact intelligently with information. …

The Effect Of Horseback Riding Activity On The Tibialis Anterior, Vastus Lateralis, And Rectus Abdominis Of A Paraplegic, Laurie A. Price

Masters Theses

Horses are now being used in various programs under various conditions. The use of horses for therapy and recreation for the physically and mentally disabled first began in Germany and Switzerland. The United States now has many schools and different riding programs as well.

Riding seems to be especially beneficial to those with neurological impairments. Treatment of paraplegia is very limited but recreational activities are advancing. The use of the horse is beneficial for paraplegics emotionally as well as physically. Measurements and evaluations of these benefits are lacking. This project analyzes and measures the physical benefits of horseback riding on …

The Relationship Between Oxygen Debt Size And Blood Ph Change During Recovery From Exercise On The Bicycle Ergometer And Treadmill, Timothy J. Falconer

Masters Theses

It was the purpose of this study to investigate the relationship of oxygen debt and blood pH change during the recovery from exercise.

For this study, ten male members of the Eastern Illinois University track team were chosen as subjects on the basis of their levels of physical condition.

The subjects were tested on three different occasions. The first test for all subjects was a fifteen minute resting oxygen consumption. Then depending upon random selection, the subjects ran on a treadmill and on another test day rode a bicycle ergometer, or vice versa. Preceding each exercise a pre-exercise micro-blood sample …

The Effect Of Iron Supplementation On The Endurance Capacity Of The Female College Athlete, Barbara B. Sachon

Human Movement Studies & Special Education Theses & Dissertations

The major parameter of interest was the effect of iron supplementation on endurance capacity of female college athletes. Secondary parameters included the evaluation of the effect of iron supplementation on the following hematological variables: white blood cell count, red blood cell count, hemoglobin concentration, and hematocrit. Nineteen volunteer female students enrolled at the College of William and Mary in Williamsburg, Virginia served as subjects, All were members of the swimming team. All test trials and venipunctures were done at the women's gym at the College of William and Mary. There were two test periods.

All nineteen subjects performed a 500 …

The Effects Of Warm-Up Duration On The Physiological Responses Of Trained Runners To A Strenuous Treadmill Test, David Eldon Fix

Masters Theses

No abstract provided.