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Articles 5011 - 5040 of 293039
Full-Text Articles in Entire DC Network
Discovery Of A New Cataclysmic Variable, Galex J211240.9–422959, Via The Exoasteroids Citizen Science Project, Mei Lin, Aaron Meisner, Siyi Xu, Arttu Sainio, Liliana E. Rivera Sandoval, Paula Szkody, Christopher Tanner, Laura K. Rogers, Sarah Casewell, Austin Humphreys
Discovery Of A New Cataclysmic Variable, Galex J211240.9–422959, Via The Exoasteroids Citizen Science Project, Mei Lin, Aaron Meisner, Siyi Xu, Arttu Sainio, Liliana E. Rivera Sandoval, Paula Szkody, Christopher Tanner, Laura K. Rogers, Sarah Casewell, Austin Humphreys
Physics & Astronomy Faculty Publications
We report the discovery and spectroscopic classification of a new cataclysmic variable (CV), GALEX J211240.9–422959 (Gaia DR3 source ID 6580244356829724928). This object was initially identified as a source exhibiting strong mid-infrared variability in Wide-field Infrared Survey Explorer (WISE) time-series data by a volunteer participating in the Exoasteroids citizen science project. Prompted by this strong variability at 3–5 μm, we obtained a follow-up optical spectrum using the Gemini Multi-Object Spectrograph at the Gemini South Observatory. The resulting spectrum displays a blue continuum dominated by strong, broad emission lines of the hydrogen Balmer series and neutral helium, spectral signatures characteristic of …
A Search For Magnetically Active Binary Counterparts To Chandra X-Ray Sources In 47 Tucanae With Hst Imaging, Haldan N. Cohn, Phyllis M. Lugger, Craig O. Heinke, Maureen Van Den Berg, Liliana Rivera Sandoval, Jay Anderson
A Search For Magnetically Active Binary Counterparts To Chandra X-Ray Sources In 47 Tucanae With Hst Imaging, Haldan N. Cohn, Phyllis M. Lugger, Craig O. Heinke, Maureen Van Den Berg, Liliana Rivera Sandoval, Jay Anderson
Physics & Astronomy Faculty Publications
Using Hubble Space Telescope (HST) imaging, we searched for candidate magnetically active binary (AB) counterparts to low-luminosity Chandra X-ray sources in the globular cluster 47 Tucanae (NGC 104). We consider the catalog of 300 Chandra sources within the half-light radius of 47 Tuc compiled by C. O. Heinke et al. (2005). The 10-band HST imaging used to identify these sources spans the range from 275–658 nm. We generated a cross-matched catalog of objects detected by photometric reductions. We used this catalog to search for counterparts within Chandra source error circles using color–magnitude diagrams and a color–color plot. We …
Ecovoltaic Solar Energy Development Creates Novel Microclimate, Temperature, And Soil Moisture Patterns Under Solar Panels In A Warm Desert, Juan Pinos, Seth M. Munson, Claire C. Karban, Matthew D. Petrie
Ecovoltaic Solar Energy Development Creates Novel Microclimate, Temperature, And Soil Moisture Patterns Under Solar Panels In A Warm Desert, Juan Pinos, Seth M. Munson, Claire C. Karban, Matthew D. Petrie
Life Sciences Faculty Research
Background As solar energy development expands in desert regions, new installation practices and solar technologies seek to balance ecosystem conservation and energy generation (ecovoltaics). The Gemini Solar Project, a large ecovoltaic facility located in the northeastern Mojave Desert, employed low impact installation methods to reduce disturbance of the desert ecosystem within arrays of bifacial panels mounted on solar tracking systems. We evaluated microclimate and environmental conditions across five locations: four within-facility microsites (underneath solar panels, east and west panel driplines, and interspaces between panel rows) and one in the undisturbed desert outside the facility. Results Under panel microsites experienced lower …
Multi-Jurisdictional Hazard Mitigation Plan For Landslides For The Kentucky River Area Development District, Kentucky, Hudson J. Koch, Matt M. Crawford, Jason M. Dortch
Multi-Jurisdictional Hazard Mitigation Plan For Landslides For The Kentucky River Area Development District, Kentucky, Hudson J. Koch, Matt M. Crawford, Jason M. Dortch
Contract Reports--KGS
Landslides are a widespread and complex geologic hazard that affects people and infrastructure. The Kentucky River Area Development District, Kentucky, sustains relatively high landslide activity that impacts several municipalities in eastern Kentucky. This hazard mitigation planning project outlines landslide hazard and risk assessments for the Kentucky River Area Development District, with information needed for each community in the region to develop mitigation strategies that will support infrastructure and development needs, land-use planning, situational awareness, and response and recovery actions for the communities.
Corporate Fiduciary Duties And The Climate And Biodiversity Crisis, Eric W. Orts, Sandra G. Schafhäutle
Corporate Fiduciary Duties And The Climate And Biodiversity Crisis, Eric W. Orts, Sandra G. Schafhäutle
Michigan Journal of Environmental & Administrative Law
This Article argues that addressing one of the most urgent environmental challenges facing humanity today—the global climate and biodiversity crisis—calls for a transformation at the heart of corporate law: its fiduciary duties. After demonstrating how current corporate fiduciary duties are implicated in this crisis, we argue for reform of fiduciary duties operating at two levels: those governing directors and officers of business corporations, and those governing institutional investors and asset managers. We then distinguish between two general kinds of corporate fiduciary duties: permissive and mandatory. We contend that corporate law should accommodate a more expansive understanding of fiduciary duties by …
The Energy And Environmental Footprint Of Ai, Michael P. Vandenbergh, Ethan I. Thorpe, Jonathan M. Gilligan
The Energy And Environmental Footprint Of Ai, Michael P. Vandenbergh, Ethan I. Thorpe, Jonathan M. Gilligan
Michigan Journal of Environmental & Administrative Law
Artificial intelligence (AI) has the potential to create major economic and social benefits, but also to rapidly escalate electricity demand and its associated environmental impacts. Information availability has been a cornerstone of environmental law for half a century, and this Article argues that providing information to individual, corporate, and other users about the electricity demand and environmental impacts of AI can reduce those impacts without delaying development of the technology. Little is known about how different large language models (LLMs) compare on these metrics, though. To address whether users have access to the information necessary to address this shortcoming, the …
Four Decades, No Progress: Time For A Columbia River Basin Compact, Liesl L. Bogaard
Four Decades, No Progress: Time For A Columbia River Basin Compact, Liesl L. Bogaard
Michigan Journal of Environmental & Administrative Law
Since the Power Act’s passage in 1980, the government entities who develop and implement energy policy in the Pacific Northwest have operated under a congressional mandate to protect fish and wildlife in the Columbia River Basin. However, nearly half a century later, the number of wild salmon and steelhead returning to their native spawning grounds is still in decline, largely due to dam operations in the Columbia and its tributaries. This Note examines the history of hydroelectric power generation in the Columbia River Basin and its impact on fish populations, drawing parallels between the environmental crisis in the Columbia River …
Owning Geothermal Energy, Gabriel Eckstein
Owning Geothermal Energy, Gabriel Eckstein
Michigan Journal of Environmental & Administrative Law
Geothermal energy holds vast potential for decarbonizing the U.S. energy system, yet the sector remains significantly underdeveloped, supplying only 0.4% of the nation's electricity. A principal barrier to growth is the fragmented and ambiguous legal landscape currently governing ownership of geothermal resources: thirty-three states lack any clear statutory or common-law framework identifying who owns subsurface thermal energy. This Article examines the physical characteristics of geothermal energy, recent developments in the U.S. geothermal sector, and the principal doctrinal approaches that might govern ownership of subsurface heat, including the ad coelum doctrine, common-pool and open-access frameworks, the rule of capture, and public …
Dendrimer Nanogels With Built-In Free Radical Scavenging Enable Efficient Topical Delivery Of A Hydrophilic Antioxidant To Restore Lens Redox Balance For Cataract Treatment, Lin Qi, Huari Kou, Anna Chernatynskaya, Da Huang, Vimalin Jeyalatha Mani, Humeyra Karacal, Nuran Ercal, Hu Yang
Dendrimer Nanogels With Built-In Free Radical Scavenging Enable Efficient Topical Delivery Of A Hydrophilic Antioxidant To Restore Lens Redox Balance For Cataract Treatment, Lin Qi, Huari Kou, Anna Chernatynskaya, Da Huang, Vimalin Jeyalatha Mani, Humeyra Karacal, Nuran Ercal, Hu Yang
Chemistry Faculty Research & Creative Works
Cataract is a leading cause of vision impairment worldwide and are primarily caused by oxidative stress that damages and aggregates lens proteins, leading to lens opacification. However, the eye's anatomical barriers limit the penetration and bioavailability of antioxidant therapies. To address this challenge, a dendrimer-based nanogel with a built-in reactive oxygen species (ROS)-scavenging capability developed by us was employed to deliver the antioxidant N-acetylcysteine (NAC) to the lens. NAC was loaded into a generation-5 PEGylated poly(amidoamine) dendrimer (G5-PEG-TK, termed the GPT) nanogel. The resulting NAC-GPT was characterized for its ROS-scavenging activity, bioavailability, and corneal permeability. The efficacy of NAC-GPT was …
Match-A-Fit, Brianna Mendoza, Adan Diaz De Leon, Pedro Jacobo, Juan Marco Saca Dada
Match-A-Fit, Brianna Mendoza, Adan Diaz De Leon, Pedro Jacobo, Juan Marco Saca Dada
Posters - 2026
Welcome to Match-a-Fit! Match-a-Fit is an iOS application that allows the user to create a digital closet by uploading images of their clothing items. With AI, the program can generate outfits based on the digital closet, the time, and the occasion. Match-a-Fit’s purpose is designed to help users who struggle to get ready, run out of time, or can’t decide on an outfit, by easily generating outfit options based on the occasion.
Maddenlite, Sergio Pena
Maddenlite, Sergio Pena
Presentations - 2026
Problem •“What If” scenarios impossible to test accurately •Commercial games rely on arcade physics •Spreadsheets lack visual engagement
Motivation •Passion for football analytics •Desire to simulate cross-era matchups •Apply math models to real-world sports data
Solution •Python based simulation engine using historical play-by-play data •Simulates outcomes based on probability
A.I.R.E., Laurene Robinson
A.I.R.E., Laurene Robinson
Presentations - 2026
•Cybersecurity analysts rely on reverse engineering to understand suspicious software. •Ghidra can surface decompiled code, but it does not fully explain function purpose, behavioral meaning, or analyst priority. •When symbols are stripped and context is weak, analysts must still reconstruct intent manually from low-level output. •That process is Time-consuming , complex and , operationally costly
Co-Ordination Driven Heteroleptic Self-Assembly Of Naphthalene Diimide And Aromatic Dicarboxylate, Rosanna Jees, Kennedy Kuchta, Joshua Do, Erendra Manandhar
Co-Ordination Driven Heteroleptic Self-Assembly Of Naphthalene Diimide And Aromatic Dicarboxylate, Rosanna Jees, Kennedy Kuchta, Joshua Do, Erendra Manandhar
Posters - 2026
Co-ordination driven self-assembly is a powerful tool to construct supramolecular co-ordination complexes (SCCs) with predictable and well-defined molecular structures. Fujita, Stang, Newkome, & others have developed novel methodology to synthesize 2D & 3D Metallo-supramolecular structures, such as triangles, cubes, and octahedrons. These have potential applications for optical materials, sensing, catalysis, light harvesting & emissions due to the structures’ well-defined cavity and easy functionalization at the periphery position of ligands.1–4 SCCs with various functional groups, fluorophores, and chromophores, like crown ethers, carbazoles, fullerenes, and dendrimers, have been reported through self-assembly, yet naphthalene-diimide (NDI)-based macrocycles and cages are limited. This project focuses …
Harvest Scanner, Alexander Murphy
Harvest Scanner, Alexander Murphy
Posters - 2026
In current times, people can find themselves at the whims of markets and may be spending more than they realize or want to on regular, everyday goods. New tools can help users keep track of the goods they are paying for. Harvest Scanner was developed to scan and track local grocery prices from stores using their publicly available website information. It was developed in Python using PyQt5 for GUI. The database is stored as an SQL file with Python using SQLite engine. Users will be able to view local grocery prices in a database interface (GUI). There are many features …
A.I.R.E. - Ai-Assisted Reverse Engineering, Laurene Robinson
A.I.R.E. - Ai-Assisted Reverse Engineering, Laurene Robinson
Posters - 2026
Reverse engineering plays a vital role in cybersecurity by helping analysts examine unknown binaries, investigate malware, identify vulnerabilities, and better protect sensitive systems. However, once a program is compiled and stripped, the meaningful names that describe its behavior are lost, leaving behind generic function labels like FUN_00401a30. Analysts must then manually interpret decompiled code, trace call chains, and infer program behavior function by function, which is slow and mentally demanding on large binaries. To address this challenge, this project introduces A.I.R.E., a local Ghidra extension that extracts contextual evidence from stripped functions and uses a locally hosted language model to …
Topshelf, Ayden Jay Soliz
Topshelf, Ayden Jay Soliz
Posters - 2026
With so many great video games releasing each year, it becomes challenging to keep up with the latest. Players find it difficult to maintain an updated list of future games to play, and many existing online trackers have become too complicated to use. TopShelf is designed to be a simple video game backlogging website that will track games for the player. By connecting to an online video game database API, users can add/drop games from their personal list and enable tracking and receive emails for platform releasing. Gamers can leave all the tracking and updates responsibilities to TopShelf
Machine Learning In Fundamental Physics: From Early Universe Signatures To Qcd Evolution, Brandon Stevenson
Machine Learning In Fundamental Physics: From Early Universe Signatures To Qcd Evolution, Brandon Stevenson
Physics Theses and Dissertations
In both cosmology and small-x quantum chromodynamics, the relevant theoretical predictions are well-defined but expensive to evaluate repeatedly over broad parameter spaces or large ensembles of simulated data. The central question of this thesis is when machine learning can accelerate those calculations without weakening the reliability of the final physics conclusions. The thesis develops and tests this idea in three settings. First, it studies the Derivative Approximation for Likelihoods (DALI) as a means of diagnosing when Fisher-matrix forecasts cease to be trustworthy in cosmological parameter inference. Second, it investigates graph-based spherical neural networks for estimating primordial non-Gaussianity directly from simulated …
Synthesis Of Copper-Phenanthroline Complexes: A Solvothermal-Compatible Approach For The Exploration Of Metal Complexes, Yunping Zhoujin, Michael Anim Safo, Navindra Keerthisinghe, Mark D. Smith, Sophya Garashchuk, Hans Conrad Zur Loye
Synthesis Of Copper-Phenanthroline Complexes: A Solvothermal-Compatible Approach For The Exploration Of Metal Complexes, Yunping Zhoujin, Michael Anim Safo, Navindra Keerthisinghe, Mark D. Smith, Sophya Garashchuk, Hans Conrad Zur Loye
Faculty Publications
Inorganic–organic hybrid materials have been widely investigated for their applications in catalysis, optics, magnetism, and biomedicine. Copper halide complexes are of particular interest due to their structural diversity and physicochemical properties. Conventional crystal growth approaches, such as slow evaporation and hydro(solvo)thermal synthesis, typically require extended reaction times and often favor thermodynamically stable phases. In this study, we prepared ten copper-phenanthroline halide (X = Cl, Br, and I) complexes using both traditional hydrothermal reactions and microwave-assisted hydrothermal methods and obtained [CuI(C12H8N2)2][I3], [C12H9N2][CuI2]·(H2 …
Lego®-Based Cubesats For Space Outreach, Stefan Brandle, Joshua Brown, Evan Smith, Drew Nye, Sydney Reddy, Twidy Kwae, Kaiya Grzesiak, Matthew Roderer, John Hetz
Lego®-Based Cubesats For Space Outreach, Stefan Brandle, Joshua Brown, Evan Smith, Drew Nye, Sydney Reddy, Twidy Kwae, Kaiya Grzesiak, Matthew Roderer, John Hetz
Faculty-Led Student Projects in CSE
Taylor University Computer Science and Engineering, in collaboration with NearSpace Education, has initiated a multi-year effort to enhance space-awareness by offering K-12 students career-impacting opportunities to build and fly satellites that have a LEGO®-robotics-based payload. This effort is intended as an outreach in the spirit of the ThinSat project (2017-2021) supported by Virginia Space, Twiggs Space Lab, Orbital ATK, NearSpace Launch, and the NASA Wallops Flight Facility, among others. We hope to receive permission to name the satellite LEGO-SAT-0.
Deep Learning Frameworks For Biological Data Integration And Generation, Alexa Beachum
Deep Learning Frameworks For Biological Data Integration And Generation, Alexa Beachum
Statistical Science Theses and Dissertations
Data integration represents a key area of research for analyzing the rapidly growing volume of high-dimensional biological data across sources, stages, and modalities. To model and understand these complex, often non-linear relationships, deep learning has become an increasingly powerful tool. Here, we present two novel deep learning frameworks that address distinct but complementary integration challenges. The first framework aligns single-cell omics data across temporal stages, and the second bridges imaging and omics modalities to generate patient-level molecular profiles.
In Chapter 1, we briefly summarize existing approaches---both statistical and deep learning-based---for single-cell omics data integration and discuss their limitations for handling …
Water Current, Volume 58, No. 1, Spring 2026
Water Current, Volume 58, No. 1, Spring 2026
Water Current Newsletter
No abstract provided.
Evaluation Of Seal!Nd: School Year 2024-2025, Shawnda Schroeder, Rashid Ahmad
Evaluation Of Seal!Nd: School Year 2024-2025, Shawnda Schroeder, Rashid Ahmad
Indigenous Health Faculty Publications
Dr. Schroeder and Rashid worked with the team at the Oral Health Program to collect data on the clinical reach of the School-based Sealant program (SEAL!ND), the referral practices, dental sealant cost savings, and perceptions of school personnel regarding their experiences with the program. SEAL!ND continues to make a measurable difference in improving children’s oral health by increasing access to preventive care, reducing barriers for families, and supporting schools in meeting the needs of their students. The program’s impact is reflected not only in the thousands of services provided each year, but also in the strong satisfaction and gratitude expressed …
Coastal Flooding And Community Resilience: Evaluating Management Strategies For Pawleys Island, Lindsey Degrendel
Coastal Flooding And Community Resilience: Evaluating Management Strategies For Pawleys Island, Lindsey Degrendel
Goal 11: Sustainable Cities and Communities
No abstract provided.
Next-Generation Democratic Cyber Statecraft - Balancing The Signal: Shutdown Shocks And Democratic Digital Governance, Scott M. Di Panni
Next-Generation Democratic Cyber Statecraft - Balancing The Signal: Shutdown Shocks And Democratic Digital Governance, Scott M. Di Panni
School of Public Policy Capstones
This paper develops Next-Generation Democratic Cyber Statecraft (NG-DCS), a unified strategic doctrine for democratic governments to contest the cognitive domain against authoritarian adversaries. Drawing on twenty-six years of cross-national panel data (1999–2024) spanning 213 countries, game-theoretic modeling, and qualitative case analysis, the paper establishes three interconnected empirical and theoretical foundations. First, cross-national OLS regression across 160+ countries demonstrates that regime type is the dominant structural determinant of internet freedom (R²=0.615, β=2.513, p< 0.001), explaining more than twice the variance attributable to per-capita wealth (R²=0.268). Democratic governance, not economic development, produces open digital environments. Second, a two-way fixed effects (TWFE) difference-in-differences study exploiting government-ordered internet shutdowns as discrete policy interventions finds that digital restrictions causally degrade V-Dem governance quality by 0.21–0.38 standard deviations (p< 0.001 across all specifications). Treatment effects are immediate (β=−0.302 at k=0) and persist through five post-treatment years (β=−0.246 at k=+5), indicating structural rather than transitory governance damage. Parallel trends validation (p=0.352) and Callaway–Sant’Anna heterogeneity-robust estimation (ATT=−0.230, SE=0.077) support causal identification. Instrumental variable triangulation (2SLS β=−0.949, p=0.005) confirms that simultaneity was attenuating, not inflating, the primary estimates. Third, formal game-theoretic analysis reveals that the current U.S.–adversary equilibrium is (Restrain, Escalate)—the risk-dominant but Pareto-inferior outcome of a Stag Hunt structure. China, Russia, North Korea, and Venezuela each occupy structurally distinct positions (Stackelberg commitment, asymmetric two-level, autarky, and reactive trigger, respectively), requiring differentiated doctrinal responses rather than a uniform strategic playbook. Generative AI and algorithmic governance are shown to accelerate cognitive vulnerability by collapsing influence operation costs and exploiting engagement-optimized platform architectures that systematically degrade deliberative capacity in democratic populations.
Inferring The Breakdown Scales Of The Chiral Expansions For GA And MN, Andreas Ekström, Daniel R. Phillips, Lucas Platter, Matthias Schindler
Inferring The Breakdown Scales Of The Chiral Expansions For GA And MN, Andreas Ekström, Daniel R. Phillips, Lucas Platter, Matthias Schindler
Faculty Publications
We apply Bayesian inference to the order-by-order chiral perturbation theory (χPT) expansions for the axial-vector coupling constant gA and the nucleon mass mN, and thereby infer the scales at which χPT breaks down for these two observables. Using a pointwise Bayesian analysis, we find that the inferred breakdown scales are notably different for the two observables. For the chiral expansion of gA, we obtain 251+20−50 MeV and 211+20−30 MeV using two distinct sets of low-energy constants, while for the chiral expansion of mN we infer a significantly …
Trade Liberalization Under Safta And Bimstec: Evidence From A Cge-Gtap Case Study Of A Small Open Economy, Gita Bhushal, Pankaj Lal
Trade Liberalization Under Safta And Bimstec: Evidence From A Cge-Gtap Case Study Of A Small Open Economy, Gita Bhushal, Pankaj Lal
Department of Earth and Environmental Studies Faculty Scholarship and Creative Works
Regional trade liberalization via preferential agreements increasingly shapes economic outcomes in small open economies embedded in overlapping regional frameworks. This study evaluates the short-run economy-wide effects of tariff and non-tariff measure (NTM) reforms under the South Asian Free Trade Area (SAFTA) and the Bay of Bengal Initiative for Multi-Sectoral Technical and Economic Cooperation (BIMSTEC) using a Computable General Equilibrium (CGE) model calibrated to the GTAP 10 database. Gravity-based estimates of ad valorem equivalents (AVEs) of NTMs are integrated into the CGE framework, enabling explicit modeling of regulatory barriers alongside tariff reductions. Policy simulations examine scenarios involving a 90 percent tariff …
Watch Me Watch: Reaction Videos As A Social Form Of Online Video Engagement, Rodney Okyere, Carlos Augusto Bautista Isaza, Jaehoon Pyon, Ihudiya Finda Ogbonnaya-Ogburu, Shuo Niu, Sang Wong Lee
Watch Me Watch: Reaction Videos As A Social Form Of Online Video Engagement, Rodney Okyere, Carlos Augusto Bautista Isaza, Jaehoon Pyon, Ihudiya Finda Ogbonnaya-Ogburu, Shuo Niu, Sang Wong Lee
Computer Science
Reaction videos (RVs) are surging in popularity, emerging as a distinctive facet of participatory culture on modern social video-sharing platforms such as YouTube, TikTok, and Twitch. This study aims to explore not only the motivations and engagement patterns of viewers towards RVs, but also the underlying nature of the virality and community-building phenomena that this sub-genre of video content fosters. We conducted 16 semi-structured interviews with individuals who identified as regular viewers of reaction videos to gain a deeper understanding of how they discover reaction videos (RQ1), the values that drive their motivations for viewing RVs (RQ2), and the ways …
Steric And Electronic Considerations Of Ester Hydrolysis: Updating A Longstanding Physical Organic Kinetics Experiment, Mara J. Aucoin
Steric And Electronic Considerations Of Ester Hydrolysis: Updating A Longstanding Physical Organic Kinetics Experiment, Mara J. Aucoin
Chemistry Theses
A current, longstanding undergraduate physical chemistry kinetics experiment uses UV-Vis spectrophotometry to follow the hydrolysis of para-nitrophenyl acetate (NPA) with an imidazole (Im) catalyst. The catalyzed and uncatalyzed reaction paths can be studied simultaneously under pseudo first order conditions ([Im]>>>[NPA]). To obtain the rate constants for the catalyzed and uncatalyzed reactions, the concentration of imidazole is varied between reactions and then plotted against the observed rate constant (kobs).This produces a linear line where the slope is equal to the rate constant of the catalyzed reaction (kcat) and the intercept is equal to …
Targeting Oncogenes: Development And Characterization Of Aurka And Her2 Inhibitors, Itzel Montoya
Targeting Oncogenes: Development And Characterization Of Aurka And Her2 Inhibitors, Itzel Montoya
Chemistry Theses
Targeted inhibition of oncogenes has remained a key strategy in the development of more potent, effective, and less toxic therapeutic anticancer agents. Among the most clinically significant signaling pathways are those mediated by the Human Epidermal Growth Factor Receptor 2 (HER2) and Aurora Kinase A (AurKA). HER2 is a member of the ErbB receptor family that supports cell growth and proliferation through downstream signaling of the PI3K and MAPK pathways and is closely linked to more aggressive tumors and therapeutic resistance. AurKA is a protein kinase essential for mitotic spindle assembly, centrosome maturation, and other key processes in cell cycle …
Efficacy Analysis In Clinical Trials: A Comprehensive Review Of Statistical And Machine Learning Approaches, Dhrubajyoti Ghosh, Samhita Pal
Efficacy Analysis In Clinical Trials: A Comprehensive Review Of Statistical And Machine Learning Approaches, Dhrubajyoti Ghosh, Samhita Pal
Faculty Articles
Efficacy testing is a cornerstone of clinical trials, ensuring that medical interventions achieve their intended therapeutic effects. Over the decades, a wide range of statistical methodologies have been developed to address the complexities of clinical trial data, including parametric, nonparametric, Bayesian, and machine learning approaches. Parametric methods, such as t-tests, ANOVA, and LMMs, have traditionally been the foundation of efficacy testing due to their efficiency under well-defined assumptions. Nonparametric techniques, including the Friedman test, Brunner-Munzel test, and modern extensions like nparLD, have emerged as robust alternatives, particularly for skewed, ordinal, or non-normal data. Bayesian methodologies have enabled the incorporation of …