Digital Commons Network^™

Brain-Targeted Reactive Oxygen Species In Hypertension: Unveiling Subcellular Dynamics, Immune Cross-Talk, And Novel Therapeutic Pathways, Renjun Wang, Min Wang, Dongshu Du, Zhiying Shan, Lanrong Bi, Qing-Hui Chen

Michigan Tech Publications

Hypertension (HTN) is a complex disease with significant global health implications, driven by neural and oxidative mechanisms. Reactive oxygen species (ROS), once considered mere metabolic byproducts, are now recognized as one of the key contributors to dysfunction of the autonomic nerve system, which involves the onset and progression of HTN. This review highlights the dynamic roles of ROS in neuronal signaling, subcellular compartmentalization, and brain-immune interactions, focusing on their impacts on synaptic remodeling, neuroinflammation, and epigenetic modifications within key autonomic regions such as the paraventricular nucleus and rostral ventrolateral medulla. We discuss novel ROS sources, including microglia-derived and endoplasmic reticulum …

Automated Data Analysis For Concussion Patient Records: A Flutter-Based Desktop Application, Fhaheem Tadamarry

USF Tampa Graduate Theses and Dissertations

Concussions are a prevalent and complex medical condition requiring careful clinical assessment and data-driven insights for effective management. This thesis presents the development of an automated data analysis system for concussion patient records, integrating Flutter-based desktop application development with SQL-driven data processing. The system provides a streamlined, interactive interface for clincians and researchers to upload, visualize, and analyze patient data efficiently.

The proposed solution automates data cleaning, preprocessing, and statistical analysis, ensuring robust and reliable insights into demographic, clinical, and recovery-related factors. Key analyses include sex-based differences injury mechanisms, prior head injury impact, mood disorder correlations, and time-to-treatment variations. The …

Recent Advances In Non-Enzymatic Electrochemical Sensors For Theophylline Detection, Gustria Ernis, Yulia M T A Putri, Muhammad Iqbal Syauqi, Prastika Krisma Jiwanti, Yeni Wahyuni Hartati, Takeshi Kondo, Qonita Kurnia Anjani, Jarnuzi Gunlazuardi

Journal of Electrochemistry

Detection of target analytes at low concentrations is significant in various fields, including pharmaceuticals, healthcare, and environmental protection. Theophylline (TP), a natural alkaloid used as a bronchodilator to treat respiratory disorders such as asthma, bronchitis, and emphysema, has a narrow therapeutic window with a safe plasma concentration ranging from 55.5–111.0 μmol·L^–1 in adults. Accurate monitoring of TP levels is essential because too low or too high can cause serious side effects. In this regard, non-enzymatic electrochemical sensors offer a practical solution with rapidity, portability, and high sensitivity. This article aims to provide a comprehensive review of the recent developments …

Exploring Corona Discharge In Electrostatic Printing For Electronics And In Other Application, Zijian Weng

USF Tampa Graduate Theses and Dissertations

The field of printed electronics (PEs) is expanding rapidly, driven by increasing market demand. According to reports, the global market for PEs is expected to reach $23 billion by 2026, with a compound annual growth rate of 18.3% from 2023 to 2028. This growth necessitates the development of innovative printing technologies that can meet these demands efficiently, delivering high-quality, high-resolution PEs suitable for applications in health, environmental monitoring, sports, aerospace, and more.

Currently, PEs manufacturing relies on two main groups of printing technologies. Contact printing methods offer high-speed production but struggle with precision, while non-contact methods provide high resolution but …

College Of Natural Sciences 2024 Year-End Publication, College Of Natural Sciences

College of Natural Sciences Newsletters and Reports

Page 2 Dean's Message
Page 3 Department Highlights
Page 4 One Day for State
Page 5 New Students in Wecota
Page 6-8 Faculty Excellence
Page 9 SDSU Physics Students Recognized
Page 9 Prairie Doc Watch Party
Page 10-11 Student Excellence
Page 11 Connections Abroad
Page 12-13 CNS’s Research Centers
Page 14 Connections Abroad
Page 14 Dean Wolf-Hall Retired
Page 15 Outreach Program
Page 15 Events and Traditions
Page 16 Student Spotlight
Page 17 Alumni Spotlight
Page 18-19 SDSU Alum at Paris Paralympics
Page 20 Work Anniversaries & Programs

The Mechanistic Target Of Rapamycin Mediates Clostridium Perfringens-Induced Chicken Necrotic Enteritis Attenuated By Secondary Bile Acid Deoxycholic Acid, Mohit Bansal, Tahrir Alenezi, Ying Fu, Janashrit Shrestha, Ayidh Almansour, Hong Wang, Anamika Gupta, Rohana Liyanage, Xiaolun Sun

Poultry Science Faculty Publications and Presentations

Clostridium perfringens is a prevalent gut bacterial pathogen in humans and animals. This study investigated the role of the mechanistic targets of rapamycin (mTOR) and deoxycholic acid (DCA) on C. perfringens intestinal infection. Chickens were sequentially infected with Eimeria maxima and received the mTOR inhibitor rapamycin and DCA. C. perfringens-induced necrotic enteritis (NE) was evaluated using body weight gain (BWG), histopathology, bile acids, pathogen colonization, cell infiltration and death, and gene expression. The significant difference of p < 0.05 was analyzed by one-way ANOVA and multiple comparisons. Notably, rapamycin strongly reduced the subclinical and clinical NE histopathologies. DCA and DCA combined with rapamycin alleviated clinical NE and BWG loss. Rapamycin, DCA, and DCA + rapamycin attenuated bile acid reduction in NE birds, and they also reduced immune cell infiltration into the intestinal lamina propria as well as immune cell migration in vitro. At molecular levels, DCA and DCA + rapamycin reduced proinflammatory IFN gamma, MMP9, IL23, and IL17 gene expression. Rapamycin, DCA, and DCA + rapamycin reduced NE-induced intestinal cell apoptosis. Together, these results suggest that mTOR signaling mediates C. perfringens-induced ileitis, and combining mTOR inhibition and DCA improves the intervention efficacy against NE ileitis and BWG loss.

Parrotfeather (Myriophyllum Aquaticum): Biology And Management Options In Utah, Francielli S. De Oliveira

Spring Runoff Conference

Parrotfeather (Myriophyllum aquaticum)

• Invasive weed from South America.
• Heterophilic perennial dioecious plant (female in the US).
• Forms dense mats, blocks waterways, and outcompetes native species
• Spreads via rhizomes, stolons, and stem fragments.

Harvest Management And Regrowth Of Trifolium Alexandrinum, R E. Joost, J D. Mooso

IGC Proceedings (1977-2023)

Adaptation of berseem clover (Trifolium alexandrinum) beyond the coastal regions of the southeastern United States was limited by a lack of cold tolerance prior to the release of 'Bigbee', a selection from a stand of 'Sacromonte' subjected to temperature of -15 and -18 Con successive nights in 1972. The release of Bigbee in 1985 expanded the range of berseem clover adaptation to include the entire Southeast, as far north as Oklahoma (Knight, 1985). It is known that annual clovers do not rely on root reserve carbohydrates, but rather on residual leaf area and rapid leaf regeneration from active …

Marine Heatwave Conditions In Western Australia Marine Waters - 26th March 2025, Department Of Primary Industries And Regional Development, Western Australia

Marine Heatwave Notification Reports

Marine heatwave (MHW) conditions across the state have persisted. Category 1 – Moderate conditions continue for the Gascoyne and South Coast Bioregions. The North Coast Bioregion has returned to Category 1 – Moderate conditions. The West Coast Bioregion remains warm but is not categorised as experiencing MHW conditions.

Per- And Polyfluoroalkyl Substance (Pfas) Degradation In Water And Soil Using Cold Atmospheric Plasma (Cap): A Review, Victor Somtochukwu Mbanugo, Boluwatife Stephen Ojo, Ta Chun Lin, Yue-Wern Huang, Marek Locmelis, Daoru Han

Biological Sciences Faculty Research & Creative Works

Per- and polyfluoroalkyl substances (PFASs) are persistent organic chemicals found in numerous industrial applications and everyday products. The excessive amounts of PFASs in water and soil, together with their link to severe health issues, have prompted substantial public concerns, making their removal from the environment a necessity. Existing degradation techniques are frequently lacking due to their low efficiency, cost-effectiveness, and potential for secondary contamination. Cold Atmospheric Plasma (CAP) technology has emerged as a promising alternative, utilizing energized reactive species to break down PFASs under ambient conditions. Therefore, this review examines the efficacy and effectiveness of CAP in degrading PFASs by …

Drug Targets Illumination: An Evidence-Based Data Analytics & Informatics Approach To Hypothesis Generation Through Clinical Trials And Genomic Variants, Jeremiah I. Abok

Chemistry and Chemical Biology ETDs

DRUG TARGETS ILLUMINATION: AN EVIDENCE-BASED DATA ANALYTICS & INFORMATICS APPROACH TO HYPOTHESIS GENERATION THROUGH CLINICAL TRIALS AND GENOMIC VARIANTS

Target Illumination Clinical Trial Analytics with Cheminformatics (TICTAC) introduces a scalable data integration pipeline that aggregates multivariate clinical trial evidence to systematically rank disease–target associations. By harmonizing metadata from AACT and employing confidence-scoring techniques, TICTAC facilitates hypothesis-driven target selection for drug discovery, enabling a data-driven approach to therapeutic development. In parallel, a bioinformatics-driven analysis of gnomAD exome mutations in the ZPR1 gene highlights the broader role of genetic variants in disease association. By employing variant effect predictors, protein stability modeling, and …

The Present And Future Of Ai: Ethical Issues And Research Opportunities, Ankita Srivastava, Marco Marabelli, Danielle Blanch-Hartigan, Jeffrey Moriarty, Evan Carey

Computer Information Systems Faculty Publications

Healthcare is currently a fast-changing industry with AI and generative AI (GenAI) playing a prominent role in the transformation of clinical as well as managerial practices. Clinical practices involve AI to diagnose diseases and develop new drugs and compounds, while managerial practices concern AI-supporting processes such as billing patients and insurance companies, handling electronic medical records, and supporting remote connections with patients, increasingly using virtual and augmented reality. Yet, all these opportunities offered by AI come with challenges involving potential ethical issues, such as discrimination, bias, lack of accessibility, and privacy issues. In March 2024, we organized a panel with …

Soil Health And Water Conservation, Tony Richards

Spring Runoff Conference

What are Healthy Soils? 

• Stable 
• Functional 
• Productive 
• Resilient 

Great Salt Lake Model Depletion, Katherine Wright

Spring Runoff Conference

When does water leasing make sense? Using New Information to Make Better Leases.

Lease, but only if it makes sense.

• Farmers have a legal right to use water on their farms for agriculture.
• Leasing might be a good economic decision for you, but not your neighbor.
• Leasing is voluntary, the purpose of this presentation is to explain the benefits of leasing and give you the information you need to decide if it is right for you. 

Western Australia’S Marine Heatwave Update - 27 March 2025, Department Of Primary Industries And Regional Development, Western Australia, Arani Chandrapavan

Marine Heatwave Notification Reports

No abstract provided.

An Edge Awareness-Enhanced Visual Slam Method For Underground Coal Mines, Mu Qi, Liang Xin, Guo Yuanjie, Wang Yuhao, Li Zhanli

Coal Geology & Exploration

Objective Underground coal mines commonly exhibit low illuminance, weak textures, and structuralization-induced feature degradation. These scenes lead to challenges of insufficient effective features and high mismatch rates to the visual simultaneous localization and mapping (SLAM) system, severely compromising its localization accuracy and robustness. Methods This study proposed an edge awareness-enhanced visual SLAM method. First, an edge-awareness constrained low-illuminance image enhancement module was developed. Specifically, images with clear textures and uniform illumination were obtained using the Retinex algorithm optimized using an adaptive gradient-domain guided filter. This significantly improved feature extraction performance under low and uneven lighting conditions. Second, an edge awareness-enhanced …

Tundra Recovery Post-Fire In The Yukon-Kuskokwim Delta, Alaska, Leah K. Clayton, Kevin Schaefer, Elizabeth E. Hoy, Clayton D. Elder, Nancy H. F. French, Gerald V. Frost, Et.Al.

Michigan Tech Publications

The extent of wildfires in tundra ecosystems has dramatically increased since the turn of the 21st century due to climate change and the resulting amplified Arctic warming. We simultaneously studied the recovery of vegetation, subsurface soil moisture, and active layer thickness (ALT) post-fire in the permafrost-underlain uplands of the Yukon-Kuskokwim Delta in southwestern Alaska to understand the interaction between these factors and their potential implications. We used a space-for-time substitution methodology with 2017 Landsat 8 imagery and synthetic aperture radar products, along with 2016 field data, to analyze tundra recovery trajectories in areas burned from 1953 to 2017. We found …

Role Of Eye-Tracking Technology And Software Algorithms In Enhancing Adhd Detection And Diagnosis: A Systematic Literature Review, Lauren E. Perkins

Honors College Theses

This systematic literature review explores the role of eye-tracking technology and software algorithms in enhancing the detection and diagnosis of ADHD. ADHD, a neurodevelopmental disorder affecting both children and adults, is traditionally diagnosed through behavioral assessments, which may lack objectivity. Recent studies suggest that eye-tracking, specifically focusing on saccades, fixations, and blink rates, offers the potential for more accurate and objective measures of ADHD. The review examines clinical trials, observational studies, and machine learning research to assess the correlation between ADHD and eye movement patterns. Results indicate that individuals with ADHD exhibit distinct eye movement patterns, which can be quantified …

The Boltzmann-Enskog Equation With Brownian Forcing, Aurora Wallace

LSU Doctoral Dissertations

Interacting particle systems (IPS) are used to rigorously derive partial differential equations modeling macroscopic behavior given by systems of stochastic differential equa- tions in physics, biology, and other sciences. These systems model the time evolution of n interacting particles with desired dynamics. In the n-system studied here, only two parti- cles may interact at a time (binary collisions). The particles are exchangeable; that is, the ordering of the particles does not play a role, and the interaction between the ith particle and the jth particle models an elastic collision. In this thesis, we use the method of inter- acting particle …

Alterity And Kinship: Co-Writing Posthumanist Speculative Nonfiction With Ai, Jeffrey Bardzell, Maliheh Ghajargar

Engineering Faculty Articles and Research

As a response to the climate crisis, scholarly literature has introduced new theoretical perspectives, such as posthumanism, which seek to reimagine the relationships between humans and nonhuman others, including environments, animals, and plants. Reimagining these relationships depends in large part on our ability to engage nonhumans in their otherness, or alterity, but doing so is challenging. Responding to calls throughout posthuman literature for experimental new modes of imaginative encounter with nonhumans, and inspired by speculative traditions from literature to design, we devise a methodology involving “creative experiments” aimed at disrupting, decentering, and disorienting the human-centered thinking that interferes with humans’ …

Fractional Calculus Approach For Learning Unknown Dynamic System, Haowei(Alice) Chen

USF Tampa Graduate Theses and Dissertations

The rapidly growing interest in data-driven modeling and fractional-order systems highlights a keychallenge in modern science and engineering: capturing long-memory effects and nonlinear behaviors in real-world dynamical processes. Conventional integer-order methods, while powerful, often overlook the history-dependent nature of many phenomena—ranging from viscoelastic materials to anomalous diffusion and hereditary feedback systems. This dissertation addresses that gap by blending fractional calculus with cutting-edge machine learning to create robust, memory-aware modeling and control frameworks.

Beginning with an extension of Dynamic Mode Decomposition (DMD) to fractional-order systems, we introduce Fractional Dynamic Mode Decomposition (F-DMD) as a data-driven tool that leverages Mittag- Leffler functions …

Springscape: The Nature Coast And The Making Of Modern Florida, 1820s-Present, Douglas E. Ponticos

USF Tampa Graduate Theses and Dissertations

According to an oft-repeated tale, the Florida we know today emerged as a dreamscape of tourism, retirement, and suburbanization during the second half of the twentieth century. Growth victimized nature. This dissertation deeply unsettles that story. The history of the Nature Coast exposes not just nature’s agency but its primacy in the development of modern Florida.

Using surveys, maps, census data, personal correspondence, government documents, business records, timber reports, advertising materials, and hydrological research, this dissertation follows time and water across landscapes, into the Upper Floridan Aquifer, and back out again. Each chapter explores a single landscape within the Nature …

Studying The Effect Of The Addition Of Sic Molecules As A Nanocomposite On The Optical Properties Of A Pmma-Ps Blend, Hussein Mejbel Azeez, Marwan Hadi Hussein, Hussein Abosaooda Abbood, Bahaa Hussein Rabee

Makara Journal of Science

In this study, a nanocomposite was prepared using a solution casting technique. The polymer electrolyte blend was formed by combining 0.6 mg of polymethyl methacrylate (PMMA) and 0.4 mg of polystyrene (PS). Subsequently, silicon carbide (SiC) nanoparticles were incorporated into the polymer matrix at varying and precisely measured concentrations. The composite was thoroughly mixed to ensure homogeneity, and Fourier transform infrared spectroscopy spectral analysis confirmed the absence of chemical interactions between the SiC nanoparticles and the polymer components, indicating a physically stable mixture. The above can be reflected in the synthesized compound with new properties, such as semiconductors or semi-insulators. …

Critical Appraisal Of Multidrug Therapy In The Ambulatory Management Of Patients With Covid-19 And Hypoxemia. Part Ii: Causal Inference Using The Bradford Hill Criteria, Eleftherios Gkioulekas, Peter A. Mccullough, Colleen Aldous

School of Mathematical & Statistical Sciences Faculty Publications

We continue the critical appraisal of three published case series of 119 COVID-19 patients with hypoxemia, treated in the United States, Zimbabwe, and Nigeria with similar ivermectin-based multidrug treatments, to assess the available evidence supporting a causal relationship between treatment and reduction in hospitalizations and mortality. A narrative review was conducted to assess the Bradford Hill criteria for a causal association. We used a previously proposed refinement of the Bradford Hill criteria that reorganized them into three categories of direct, mechanistic, and parallel evidence. The efficacy of the two most aggressive ivermectin-based multidrug protocols is supported by the Bradford Hill …

Unlocking Precision Using K-Means++- Improved Genetic Algorithm-Radial Basis Function Neural Network: Data-Driven Evolution Of Smart Gloves For Gesture Recognition, Liang Xiao Ding, Kuan Way Chee, Hong Lü, Anand Paul, Jeonghong Kim, Jang Myung Lee

School of Public Health Faculty Publications

Human-computer interaction technologies have been used since the 1970s but have only gained growing popularity in recent years with new design paradigms. Ongoing research and development in gesture recognition systems with broad application prospects have focused on improving accuracy and real-time performance as well as the robustness of specific machine learning algorithms against environmental conditions. This paper addresses the accuracy enhancement of a novel Fifth Dimension Technologies data-glove-based gesture recognition system using a genetic-algorithm (GA)-trained k-means++-improved radial basis function (RBF) or GK-RBF neural network. First, we analyzed and modeled the sensor distribution in the data glove and proposed joint constraints …

Value-Based Healthcare Reimagined: A Mixed-Methods Study On Behavioral Health Clinicians' Perspectives, Amanda L. Strickland

Electronic Theses and Dissertations

This study explores how behavioral health clinicians perceive Value-Based Healthcare (VBHC), a model designed by Porter and Teisberg (2006) to improve outcomes relative to costs. While widely promoted in healthcare reform, VBHC poses unique challenges when applied to behavioral health settings. Using an explanatory mixed-methods design, this study first assessed clinicians’ awareness of VBHC through a survey of 23 licensed clinicians at a Community Mental Health Center (CMHC) in Colorado. Quantitative findings revealed that one-third of participants were aware of VBHC with awareness differing by role prompting further exploration in a qualitative phase. Semi-structured interviews with eight clinicians provided deeper …

Development, Optimization, And Validation Of A High-Sensitivity Capillary Zone Electrophoresis System For Bioanalytical Applications, Aaron I. Mena

Electronic Theses and Dissertations

Capillary zone electrophoresis (CZE) is a powerful analytical technique widely used for biomolecular separation due to its high resolution, efficiency, and sensitivity. This report presents the development and validation of a novel CZE system designed to improve modularity, reproducibility, and operational efficiency. The system integrates a laser-induced fluorescence (LIF) detection method with a 488 nm laser, enhanced fluid control through a negative pressure system, and a user-friendly GUI for automated operation and data acquisition. Performance verification included pressure stability tests, fluorescence accuracy assessments, and electrophoretic reproducibility studies. Comparative analysis with a previous CZE iteration confirmed improved baseline stability, peak resolution, …

Synthetic Protein Mimetic Based Therapies For Neurodegeneration, Nicholas H. Stillman

Electronic Theses and Dissertations

Protein-protein interactions (PPIs) are crucial for the regulation of a majority of, if not every fundamental cellular process. Despite their role in regular biological processes, dysregulated and/or aberrant protein-protein interactions (aPPIs) are often related to the onset of disease including cancer, viral infection, and amyloid diseases. aPPIs have historically been deemed ‘undruggable’ due to their large surface area and lack of a binding cavity; however, today, more than 40 disease-related aPPIs have been targeted with small molecules and several of those have reached clinical trials.

A class of synthetic protein mimetics called oligopyridylamides (OPs) has been shown to inhibit disease-related …

Alternative Stones And Cleaning Efficiencies For Historical Building Stones Used In İstanbul (Türkiye), Ömer Ündül, Tuğçe Erözmen, Namik Aysal, Ahmet Güleç

Turkish Journal of Earth Sciences

Historical buildings are important part of the common heritage of mankind. İstanbul comprises many historical buildings built by geo-materials. A limestone (named as Küfeki stone in the region) is one of the most widely used stone in and around the city since thousands of years. The durability, excavability and workability of the stone attract the usage of this stone. Besides the outcrops of the rock were very common. Unfortunately, nowadays quarries and outcrops of Küfeki stone are totally abandoned due to dense settlement. For this reason, replacement of damaged or polluted stone with the original stone is a hard task …

Facies And Depositional Architecture Of Upper Miocene Tidal Flat Sedimentation In Kefalonia And Corfu Islands, West Greece, Nicolina Bourli, Chrysanthos Botziolis, Penelope Papadopoulou, Panagiotis Zelilidis, Elena Zoumpouli, George Iliopoulos, Angelos G. Maravelis, Efthymios Trypsanas, Ioannis Oikonomopoulos, Aristotelis Pagoulatos, Avraam Zelilidis

Turkish Journal of Earth Sciences

This research involves the integrated sedimentological and paleontological analysis of the Neogene tidal deposits in the eastern parts of the Hellenic Fold and Thrust Belt, in South Kefalonia (Paliolinos-Avithos coast) and in NW Corfu (Arillas coast) islands. The study of tidal is supported by illustrative outcrop photographs, with a particular emphasis on two synthetic outcrops. Sedimentary logs were generated to document detailed bed-by-bed measurements, descriptions, and identification of sedimentary structures. Additionally, over 75 samples were chosen for age determination and paleoenvironmental analysis. Micropaleontological analysis encompassed 52 samples from South Kefalonia and 23 samples from NW Corfu and the results point …