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Articles 2071 - 2100 of 78537
Full-Text Articles in Entire DC Network
Effect Of Real Quest Outdoor Learning On High School Students Climate Literacy, Siti Aisah, Abdul Hakim, Puardmi Damayanti
Effect Of Real Quest Outdoor Learning On High School Students Climate Literacy, Siti Aisah, Abdul Hakim, Puardmi Damayanti
Jurnal Pendidikan Sains
This study investigates the influence of the Real Quest Outdoor Learning (ReQOL) model, which encompasses knowledge, attitudes, and behavior, on the climate literacy of high school students. A quasi-experimental design was performed with a non-equivalent control group; thus, a sample consisting of an experimental class (n = 34) and a control class (n = 32) was used. A one-way ANOVA test was used to test the differences between pretest and post-test scores at a 0.05 significance level. The basic knowledge on climate in the experimental group increased significantly (sig < 0.001), while the change in attitudes and behaviors was insignificant (sig = 0.339 and sig = 0.447, respectively). The fact that attitude and behavior did not improve significantly during the experiment can be justified by the existing Adiwiyata programme in schools. These findings indicate that the ReQOL model is a good way to help students understand climate issues better. Adding discovery-based outdoor learning to science classes has the potential to make students more aware of environmental issues and lay the groundwork for the development of responsible behavior. This underscores the scientific contribution and educational importance of the development of climate literacy within the curriculum.
Mathematical Analysis And Numerical Simulation Of A Fractional-Order Sir-Si Model For Malaria Transmission Dynamics, Gassan A. M. O. Farah, Abdulaziz Y. A. Mukhtar, Kailash C. Patidar
Mathematical Analysis And Numerical Simulation Of A Fractional-Order Sir-Si Model For Malaria Transmission Dynamics, Gassan A. M. O. Farah, Abdulaziz Y. A. Mukhtar, Kailash C. Patidar
Mathematical Modelling and Numerical Simulation with Applications
This study investigates the complex transmission dynamics of malaria, a critical global health challenge, with a focus on the African continent. We introduce a novel approach that employs Fractional Differential Equations (FDEs) to advance the understanding of malaria spread and control. Specifically, we develop a new SIR-SI model using the Caputo fractional operator, which captures the memory effects and time-delay characteristics inherent in real-world epidemiological systems. A detailed analysis of the model's solvability and uniqueness is conducted using fixed-point theory. To obtain an analytical solution, the system is solved via the Laplace transform method, with solutions expressed in closed form …
Integration Of Islamic Values In Mathematics Learning, Ai Mulya, Surya Faradiba
Integration Of Islamic Values In Mathematics Learning, Ai Mulya, Surya Faradiba
Jurnal Pendidikan Sains
This study aims to identify the integration of Islamic values in mathematics learning and its contribution to student character development. The method used is a systematic literature study by reviewing relevant accredited scientific articles. The results of the study indicate that the integration of Islamic values is carried out through the preparation of Islamic-context-based mathematics problems, linking concepts to verses of the Qur'an and hadith, the application of ethnomathematics with Islamic cultural nuances, and the introduction of Islamic economic concepts. The dominant values that emerge include honesty, responsibility, discipline, justice, and piety. These findings indicate that the integration of Islamic …
Understanding The Fidelity And Specificity Of Dna Polymerase I, Bill R. Miller Iii, Andrew V. Yeager, Jake A. Collins, Alexis Blake, Elise Tate, Carol A. Parish, Eugene Y. Wu
Understanding The Fidelity And Specificity Of Dna Polymerase I, Bill R. Miller Iii, Andrew V. Yeager, Jake A. Collins, Alexis Blake, Elise Tate, Carol A. Parish, Eugene Y. Wu
Chemistry Faculty Publications
High-fidelity DNA polymerases employ complex mechanisms to catalyze template-dependent DNA synthesis while quickly discarding mismatches. Atomic-level structural details about short-lived states during nucleotide discrimination are necessary to gain insight into the kinetic checkpoints that contribute to fidelity. We performed microsecond molecular dynamics simulations of DNA polymerase I, large fragment, from Bacillus stearothermophilus (Bacillus fragment, or BF) in complex with a template guanine and a mismatched thymidine triphosphate to observe the early events in the process of selection against a mismatch. Although the nucleobases formed a wobble base pair early, the mismatched pair was blocked from fully entering the active site …
Umwelt, Sujetos Transindividuales E Intencionalidad Compartida: Cuerpo, Significación Y Socialidad En La Construcción Del Conocimiento, Juan C. González Vidal
Umwelt, Sujetos Transindividuales E Intencionalidad Compartida: Cuerpo, Significación Y Socialidad En La Construcción Del Conocimiento, Juan C. González Vidal
Journal of Roleplaying Studies and STEAM
En este trabajo abordamos, desde el punto de vista semiótico, el vínculo indisoluble que existe entre el cuerpo humano, la significación y la socialidad. Partimos del postulado de que el cuerpo es, desde el nacimiento, una entidad sintiente; luego, una vez adquirida la capacidad de generar procesos semiósicos primarios, empieza a ordenar y a clasificar los estímulos exteriores, hecho en el que se asienta el fundamento de su orientación básica en el entorno. Conforme aumentan sus competencias semiósicas, se incrementan sus capacidades perceptivas y cognitivas que, al ser afirmadas, lo llevan a alcanzar finalmente los más altos grados de socialidad. …
Hydrothermal Vents In Sulfuric Acid Speleogenesis Karst: Isolated Feeders With Pristine Hypogenic Water Or Interconnected Conduits With Rapid Flow And Recycled Water?, Jakub Mareš, Marek Audy, Serban M. Sarbu, Jan Kukačka, Romeo Eftimi, Jiří Bruthans
Hydrothermal Vents In Sulfuric Acid Speleogenesis Karst: Isolated Feeders With Pristine Hypogenic Water Or Interconnected Conduits With Rapid Flow And Recycled Water?, Jakub Mareš, Marek Audy, Serban M. Sarbu, Jan Kukačka, Romeo Eftimi, Jiří Bruthans
International Journal of Speleology
Underwater connectivity and flow paths in the saturated zone of hypogenic sulfuric acid speleogenesis (SAS) karst remain unclear, despite sustained research over the past 30 years. Being regarded as sources of pristine H2S-charged water, narrow inflow conduits called "feeders" are typically considered primary sources of water and hotspots of speleogenesis. In southeastern Albania, there is a newly discovered active SAS karst system comprising numerous caves and springs. Tracer tests were conducted to investigate the connection of these caves to the surrounding springs and to characterize the flow paths. The results show that water flows from cave lakes to …
Physicochemical, Pharmacognostic Standardisation And Phytochemical Analyses Of The Homoeopathic Drug Justicia Adhatoda, Bibaswan Biswas, Satish Patel, Digvijay Verma, Satyajit Maity, Shilpi Singh, Paulami Majumdar, Narasimha Kumar Gv
Physicochemical, Pharmacognostic Standardisation And Phytochemical Analyses Of The Homoeopathic Drug Justicia Adhatoda, Bibaswan Biswas, Satish Patel, Digvijay Verma, Satyajit Maity, Shilpi Singh, Paulami Majumdar, Narasimha Kumar Gv
Indian Journal of Research in Homoeopathy
Background: Justicia adhatoda (J. adhatoda), also well known as Vasaka in India is a medicinal plant chiefly used to treat respiratory ailments in traditional and alternative medical systems. Objective: This study aimed to establish the physicochemical, pharmacognostic, and phytochemical standardisation parameters of the drug. The study involved the measurement of physicochemical parameters and chemical profiling of the raw drug. The chemical characteristics of the in-house mother tincture (prepared from in-house raw drug) and commercial mother tinctures available in India were also evaluated to assess the quality of commercially available mother tinctures. Materials and Methods: The present study …
Electrochemical Characterization And Modulation Of Biological Processes, Yue-Qi Li, Wei-Hua Huang, De-Chen Jiang, Bao-Hong Liu, Bin Su, Yang Tian, Jing-Juan Xu, Ping Yu, Feng Zhao, Huang-Xian Ju, Jing-Hong Li
Electrochemical Characterization And Modulation Of Biological Processes, Yue-Qi Li, Wei-Hua Huang, De-Chen Jiang, Bao-Hong Liu, Bin Su, Yang Tian, Jing-Juan Xu, Ping Yu, Feng Zhao, Huang-Xian Ju, Jing-Hong Li
Journal of Electrochemistry
Electrochemical processes lie at the core of biological function, governing energy transduction, metabolic flux, and molecular signaling. Recent advances in electrochemical science now allow these processes to be probed and controlled with unprecedented spatial, temporal, and chemical resolution. In this review, we present an integrated framework that progresses from fundamental mechanisms to analytical technologies and functional modulation. We begin by outlining electron transfer pathways in mitochondrial respiration, microbial extracellular electron transfer, and DNA- and protein-based charge conduction, followed by the principles of photon-electron conversion in photosynthesis and the central role of redox equilibrium in coordinating cellular responses. We then highlight …
(R2150) Impact Of Specialist Predator Harvesting On The Stability Of A Three-Species Food Chain Model With A Generalist Predator, S. Ganga, S. Vijaya
(R2150) Impact Of Specialist Predator Harvesting On The Stability Of A Three-Species Food Chain Model With A Generalist Predator, S. Ganga, S. Vijaya
Applications and Applied Mathematics: An International Journal (AAM)
In this study, the stability of a three-species food chain model comprising a prey, an intermediate specialist predator, and a top predator exhibiting generalist behavior is examined, with harvesting applied to the intermediate predator. The main objective is to investigate how variations in the harvesting rate influence system stability and the coexistence of all three species. The positivity, boundedness, and equilibrium points of the model are analyzed to ensure biological feasibility. The equilibrium point involving the prey and the top predator satisfies the criteria for both local and global asymptotic stability. The coexistence equilibrium point attains local asymptotic stability based …
A Method Of Heuristic Human-Llm Collaborative Source Search, Yi Chen, Sihang Qiu, Zhengqiu Zhu, Yatai Ji, Yong Zhao, Rusheng Ju
A Method Of Heuristic Human-Llm Collaborative Source Search, Yi Chen, Sihang Qiu, Zhengqiu Zhu, Yatai Ji, Yong Zhao, Rusheng Ju
Journal of System Simulation
Abstract: Traditional source search algorithms are prone to local optimization, and source search methods combining crowdsourcing and human-AI collaboration suffer from low cost-efficiency due to human intervention. In this study, we proposed a lightweight human-AI collaboration framework that utilized multi-modal large language models (MLLMs) to achieve visual-language conversion, combined chain-of-thought (CoT) reasoning to optimize decision-making, and constructed a heuristic strategy that incorporated probability distribution filtering and a balance between exploitation and exploration. The effectiveness of the framework was verified by experiments. The human-AI alignment heuristic strategy with large language model adaptation design provides a new idea to reduce manual …
Lightweight Assembly Workpiece Detection Algorithm Based On Improved Yolov8, Shuheng Wu, Yongkui Liu, Lin Zhang, Yingying Xiao, Lihui Wang
Lightweight Assembly Workpiece Detection Algorithm Based On Improved Yolov8, Shuheng Wu, Yongkui Liu, Lin Zhang, Yingying Xiao, Lihui Wang
Journal of System Simulation
Abstract: To address the issues of low recognition accuracy and slow detection speed with existing deep learning-based object detection algorithms for robotic automatic assembly tasks, a lightweight assembly workpiece object detection algorithm based on YOLOv8 was proposed. The PConv was introduced to improve the C2f module, and a new Faster_C2f module was designed to enhance the detection speed of the model. The SIoU loss function was employed to optimize the location prediction accuracy of the CIoU loss function and improve the localization accuracy of small targets. The high-level screening-feature fusion pyramid networks (HS-FPN) structure was used to improve the Neck …
Synthesis Of Biogenic Silver Nanoparticles From Apricot Kernel Extracts For The Colorimetric Determination Of Gold, Ayça Gi̇rgi̇n, Hi̇lal Akbiyik, Buse Tuğba Zaman, Omid Nejati, Ayça Bal Öztürk, Gülten Çeti̇n, Sezgi̇n Bakirdere
Synthesis Of Biogenic Silver Nanoparticles From Apricot Kernel Extracts For The Colorimetric Determination Of Gold, Ayça Gi̇rgi̇n, Hi̇lal Akbiyik, Buse Tuğba Zaman, Omid Nejati, Ayça Bal Öztürk, Gülten Çeti̇n, Sezgi̇n Bakirdere
Turkish Journal of Chemistry
Gold is abundant in nature, however, precise and reliable analytical methods for its detection are required stemming from its increasing prevalence in environmental, biological, and industrial systems, as well as the growing interest in understanding its function in living organisms and its effects on human health. This study investigates the use of biogenically synthesized silver nanoparticles (AgNPs) for the preconcentration and determination of gold ions prior to determination by UV-Vis spectrophotometry. AgNPs were synthesized by reducing silver nitrate through the use of an apricot kernel extract as both reducer and stabilizer agent. The colloidal yellowish AgNPs interacted with gold ions, …
Bioorganometallic Tagging Of N-Acetylhistamine With An Fe(Co)₃ Unit: Synthesis, X-Ray Structure, And Protonation Behavior, Salah Merniz, Louiza Himed, Rofia Djerri, Belkis Akachat
Bioorganometallic Tagging Of N-Acetylhistamine With An Fe(Co)₃ Unit: Synthesis, X-Ray Structure, And Protonation Behavior, Salah Merniz, Louiza Himed, Rofia Djerri, Belkis Akachat
Turkish Journal of Chemistry
This study highlights the potential of organometallic carbonyl complexes as selective markers for biomolecules, enabling sensitive infrared (IR) detection. The regio- and stereoselective coupling of N-acetylhistamine, a histidine analogue, with the precursor complex 1 [Fe(CO)₃(1,4-η⁵-N-pyridiniocyclohexa-1,3-diene)] BF₄ affords the labeled complex 3 [Fe(CO)₃(1,4-η⁵-N-acetylhistaminocyclohexa-1,3-diene)]. X-ray diffraction (XRD) confirms the exo stereochemistry and reveals a rigid, well-defined architecture. IR and 1H nuclear magnetic resonance spectroscopic studies combined with IR-monitored acid–base titration demonstrate the complex’s stability in aqueous media between pH 5 and 8, alongside a modest increase in basicity relative to the free ligand. These findings establish the Fe(CO)₃ moiety as a robust …
New Bis-Piperazine Derivatives: Synthesis, Characterization (Ir, Nmr), Gamma-Ray Absorption, Antimicrobial Activity, Molecular Docking And Dynamics Study, Yasemi̇n Ünver, Arzu Coşkun, Fati̇h Çeli̇k, Hali̇l İbrahi̇m Güler, Kadri̇ye İnan Bektaş
New Bis-Piperazine Derivatives: Synthesis, Characterization (Ir, Nmr), Gamma-Ray Absorption, Antimicrobial Activity, Molecular Docking And Dynamics Study, Yasemi̇n Ünver, Arzu Coşkun, Fati̇h Çeli̇k, Hali̇l İbrahi̇m Güler, Kadri̇ye İnan Bektaş
Turkish Journal of Chemistry
A series of novel bis-piperazine derivatives (2a–2f) were synthesized and structurally characterized via Fourier transform-infrared and nuclear magnetic resonance spectroscopic techniques. Their gamma-ray shielding efficiencies were investigated through simulations on the Monte Carlo-based Geant4-GATE platform, and the results were benchmarked against data obtained from the XCOM and Phy-X software. A simulation model incorporating an NaI scintillation detector and a point gamma source was developed. Key shielding parameters, including mass attenuation coefficient, linear attenuation coefficient, half-value layer, and mean free path (MFP), were evaluated at gamma energies of 80, 120, 662, 1173, and 1332 keV. Additionally, the energy absorption buildup factor …
Structural Categorization And Identification Of Electrostatic Interactions In Two Proposed Human Serum Albumin Dimerization Patterns And Dipyridamole Interaction, Haluk Çeti̇nok, Veyi̇s Karakoç, Erol Erçağ, Yusuf Meli̇h Şekerer, Hasan Demi̇rci̇
Structural Categorization And Identification Of Electrostatic Interactions In Two Proposed Human Serum Albumin Dimerization Patterns And Dipyridamole Interaction, Haluk Çeti̇nok, Veyi̇s Karakoç, Erol Erçağ, Yusuf Meli̇h Şekerer, Hasan Demi̇rci̇
Turkish Journal of Chemistry
Human serum albumin (HSA) is a ubiquitous, multifunctional protein responsible for the systemic distribution of both endogenous metabolites and exogenous pharmaceuticals. Its inherent properties, particularly its ability to seep into tissues and its multiple ligand-binding sites, have rendered HSA an attractive vehicle for nanoparticle-based drug delivery systems, particularly for cancer targeting. In this study, we present high-resolution crystallographic data revealing two distinct dimerization patterns of HSA (Protein Data Bank [PDB] ID: 9V61) obtained under high-concentration crystallization conditions, along with results from dipyridamole docking. Both dimer types demonstrate extensive interface areas and a significant number of electrostatic interactions. Comparative analysis with …
Mechanisms Behind Soil Water Evaporation And Infiltration During Long-Term Microbial Reclamation In Coal Mining-Induced Subsidence Areas In Northern Shaanxi Province, China, Ke Zengming, Bi Yinli, Yang Wei
Mechanisms Behind Soil Water Evaporation And Infiltration During Long-Term Microbial Reclamation In Coal Mining-Induced Subsidence Areas In Northern Shaanxi Province, China, Ke Zengming, Bi Yinli, Yang Wei
Coal Geology & Exploration
Background Water scarcity is identified as an important factor restricting ecological restoration in arid and semi-arid mining areas. The application of microbial reclamation technologies, especially inoculation with Arbuscular mycorrhizal fungi (AMF), has achieved encouraging ecological effects in mining areas. In this case, investigating soil water movement and its controlling factors in mining areas undergoing long-term microbial reclamation is a key scientific issue for understanding the long-term ecological restoration mechanisms of AMF. Methods This study investigated the microbial reclamation base in the coal mining-induced subsidence area of the Daliuta coal mine of northern Shaanxi Province, located in the middle reaches of …
An Experimental Study On The Selection Of Slow-Release Carbon Source Materials For Sulfate-Reducing Bacteria-Based Remediation Of High-Sulfate Mine Water In Coal Mines, Xiahou Ming’An, Zhang Li, Xu Zhimin, Guo Juan, Chen Ge, Xiong Xiaofeng, Sun Yajun
An Experimental Study On The Selection Of Slow-Release Carbon Source Materials For Sulfate-Reducing Bacteria-Based Remediation Of High-Sulfate Mine Water In Coal Mines, Xiahou Ming’An, Zhang Li, Xu Zhimin, Guo Juan, Chen Ge, Xiong Xiaofeng, Sun Yajun
Coal Geology & Exploration
Background High-sulfate mine water poses a major aquatic environmental challenge in coal mining areas across China. Accordingly, the cost-effective and efficient treatment of such water has become an urgent need for the sustainable development of the mining industry. Despite its considerable promise, microbial remediation based on sulfate-reducing bacteria (SRB) shows limited efficiency due to the scarcity of dissolved organic carbon (DOC) in mine water.Methods The application of external slow-release carbon source (SRC) materials for SRB faces a range of challenges, such as the potentially excessive release of organic carbon in the initial stage, the unclear release mechanisms of dissolved …
Water Quality Characteristics And Reutilization Of Goaf Water From Shallow Coal Seams Within The Datong Mining Area, Shanxi Province, China, Li Jun, Gui Herong, Ding Pengfei, Chen Yongqing, Wan Heyong, Li Weiqi, Huang Dawei, Peng Weihua, Hu Yang, Guo Yan
Water Quality Characteristics And Reutilization Of Goaf Water From Shallow Coal Seams Within The Datong Mining Area, Shanxi Province, China, Li Jun, Gui Herong, Ding Pengfei, Chen Yongqing, Wan Heyong, Li Weiqi, Huang Dawei, Peng Weihua, Hu Yang, Guo Yan
Coal Geology & Exploration
Objective The Datong mining area in Shanxi Province of China faces serious threats from goaf water hazards, while the goaf water drainage is constrained by environmental protection policies. Therefore, the reutilization of goaf water serves as an effective approach to eliminating mine water hazards, protecting water environments, and mitigating water scarcity in the mining area. Methods This study investigated goaf water from shallow coal seams in the Datong mining area. Based on water quality assessment theories and a range of hydrogeochemical indices, including saturation index (SI), chloro-alkaline index (CAI), and sodium adsorption ratio (SAR), this study conducted a joint determination …
Novel Spectrophotometric Method For The Determination Of Paclitaxel Through Complex Formation With Osmium, Basima A.A.Saleem, Salim A. Mohammed, Amer Th. Al-Taee
Novel Spectrophotometric Method For The Determination Of Paclitaxel Through Complex Formation With Osmium, Basima A.A.Saleem, Salim A. Mohammed, Amer Th. Al-Taee
Turkish Journal of Chemistry
Paclitaxel (Pac) is an important anticancer bioactive compound, and the availability of an accurate and robust analytical method for its quantification is of utmost importance. In this investigation, a novel, direct, and reliable spectrophotometric method has been proposed for the estimation of Pac via a complex formation reaction with osmium (Os). The method was based on the reaction of Pac with Os tetroxide, which produced a yellowish-brown complex. The resulting complex is soluble in water and displays a maximum absorption peak at 482 nm. The reaction conditions, including reactant concentration, pH, temperature, and reaction time, were optimized to obtain the …
Synthesis, Characterization, Antimicrobial, Antioxidant, And Antiinflammatory Evaluation And Molecular Docking Studies Of N-((2-Hydroxy-3-(2-(Substitutedbenzylidene)Hydrazine-1-Carbonyl)Naphthalen-1-Yl)(3-Nitrophenyl/3,4-Dimethoxyphenyl)Methyl)Acetamide Derivatives, Shikha Kamboj, Alka Yadav, Samridhi Thakral, Rekha Tanwar, Sunil Kumar, Vikramjeet Singh
Synthesis, Characterization, Antimicrobial, Antioxidant, And Antiinflammatory Evaluation And Molecular Docking Studies Of N-((2-Hydroxy-3-(2-(Substitutedbenzylidene)Hydrazine-1-Carbonyl)Naphthalen-1-Yl)(3-Nitrophenyl/3,4-Dimethoxyphenyl)Methyl)Acetamide Derivatives, Shikha Kamboj, Alka Yadav, Samridhi Thakral, Rekha Tanwar, Sunil Kumar, Vikramjeet Singh
Turkish Journal of Chemistry
Hydrazone chemistry has become important and plays a key role in the development of organic compounds. Hydrazones can be useful pharmacophores for creating novel derivatives, owing to their broad range of activities. In this study, a series of N-((2-hydroxy-3-(2-(substitutedbenzylidene)hydrazine-1-carbonyl)naphthalen-1-yl)(3-nitro-phenyl/3,4-dimethoxyphenyl)methyl)acetamide derivatives were prepared, characterized by FTIR, 1H-NMR, 13C-NMR, and mass spectroscopy, and evaluated for their antimicrobial, antiinflammatory, and antioxidant activities along with in silico studies. The substituted derivatives were synthesized by the reaction of acetonitrile, chlorosulphonic acid, and substituted benzaldehyde with the hydrazones. The antimicrobial evaluation showed that compound 3i had more antimicrobial potential than the other tested molecules. Compound 3j …
Enhancing Analytical Performance Of Tyrosinase-Based Sensors With Nanoparticles For Detection Of Isoproterenol, Aysel Oktay, Sevi̇nç Kurbanoğlu, Gülsüm Gündoğdu, Cem Bülent Üstündağ, Frieder W. Scheller, Aysu Yarman
Enhancing Analytical Performance Of Tyrosinase-Based Sensors With Nanoparticles For Detection Of Isoproterenol, Aysel Oktay, Sevi̇nç Kurbanoğlu, Gülsüm Gündoğdu, Cem Bülent Üstündağ, Frieder W. Scheller, Aysu Yarman
Turkish Journal of Chemistry
In this work, electrochemical biosensors utilizing tyrosinase (Tyr) for the detection of the nonselective beta-adrenergic agonist isoproterenol (ISO) are presented. Three different configurations for immobilizing Tyr on a graphite electrode (GE) are compared: (1) GE modified with poly(diallyldimethylammonium chloride) (PDADMAC), PDADMAC/Tyr/GE; (2) PDADMAC combined with iridium nanoparticles (IrNPs) in a stepwise preparation, resulting in PDADMAC/IrNPs/Tyr/GE; and (3) a composite of PDADMAC and IrNPs mixed with Tyr at a 1:1 (v:v), forming PDADMAC/(IrNPs-Tyr)/GE. Surface morphology was characterized using scanning electron microscopy (SEM). Cyclic voltammetry (CV) and amperometry were applied to characterize the biosensor’s performance. Within the linear range of 5 μM …
Α-Glycosidase Activity Of Novel Coumarin–Triazole–Coumarin Dyads, Ersi̇n Şi̇ri̇n, Esra Sevi̇mli̇, Gökçe Seyhan, Burak Barut, Yunus Kaya, Baybars Köksoy
Α-Glycosidase Activity Of Novel Coumarin–Triazole–Coumarin Dyads, Ersi̇n Şi̇ri̇n, Esra Sevi̇mli̇, Gökçe Seyhan, Burak Barut, Yunus Kaya, Baybars Köksoy
Turkish Journal of Chemistry
Novel coumarin–triazole–coumarin dyads were synthesized and characterized, and their α-glycosidase inhibitory activities were evaluated spectrophotometrically. Compound 4e exhibited the most pronounced inhibitory effect, with an IC50 value of 38.98 ± 0.77 μM. The IC50 values for 4d and 4a were 93.55 ± 1.70 μM and 95.04 ± 3.55 μM, respectively. The Lineweaver–Burk plot showed that 4e inhibited α-glycosidase in a mixed type. In addition, the Ki value obtained from the Dixon plot was 19.95 ± 0.15 μM for α-glycosidase.
Efficient Recovery Of Y3+ From Aqueous Media Using Mdlm Technique:Transport Behavior And Kinetic Modeling, Volkan Demi̇rel, Ramazan Donat, Hacer Şensöz
Efficient Recovery Of Y3+ From Aqueous Media Using Mdlm Technique:Transport Behavior And Kinetic Modeling, Volkan Demi̇rel, Ramazan Donat, Hacer Şensöz
Turkish Journal of Chemistry
This study investigates the extraction behavior of Y³⁺ ions using a Multi-Dropped Liquid Membrane (MDLM) system that employs di(2-ethylhexyl) phosphoric acid (D₂EHPA) as the carrier ligand. The focus is on the system’s ability to transport ions between aqueous phases selectively. The extracted complex was analyzed spectrophotometrically via ultraviolet–visible (UV–Vis) measurements after complexation with 0.05% Arsenazo III. The aim of this study was to determine the influence of the optimum D₂EHPA carrier concentration, together with the pH and temperature conditions of the donor and acceptor phases, on the system’s extraction performance. Accordingly, a series of extraction experiments was performed at different …
Utilization Of Dual Catalysts For High-Yield Boron Nitride Nanotube Synthesis Via Chemical Vapor Deposition, Şaban Kalay
Utilization Of Dual Catalysts For High-Yield Boron Nitride Nanotube Synthesis Via Chemical Vapor Deposition, Şaban Kalay
Turkish Journal of Chemistry
The direct synthesis of boron nitride nanotubes (BNNTs) via chemical vapor deposition (CVD) in high-temperature furnaces remains highly challenging due to difficulties in optimizing key experimental parameters such as synthesis temperature and catalyst composition. These challenges often result in uncontrolled growth behavior, adversely affecting the quality and yield of the BNNTs. In this study, colemanite was effectively utilized as a boron source for the high-yield synthesis of directionally aligned BNNTs. The synthesis was carried out using a CVD method that used a dual-catalyst system comprising Fe2O3 and MgO in conjunction with a silicon carbide template under high-temperature conditions. The resulting …
Road Performance And Water-Softening Characteristics Of Stabilized Soil Under Cyclic Loading, Hu Hong, Li Zongheng, Feng Yong, Cao Zhigang, Liu Yaoxing
Road Performance And Water-Softening Characteristics Of Stabilized Soil Under Cyclic Loading, Hu Hong, Li Zongheng, Feng Yong, Cao Zhigang, Liu Yaoxing
Journal of China & Foreign Highway
To effectively deal with waste soil and reduce environmental pollution,this paper took a road engineering project in Shaoxing as the research object and conducted a cyclic triaxial incremental loading test on the undisturbed lime soil under undrained conditions to study the effects of confining pressure,cyclic stress ratio,and water immersion on its performance.The results show that when the cyclic stress ratio increases from 1 to 4,the cumulative strain and resilient strain increase rapidly in the initial loading stage,showing a trend of “stepwise” increase.The cumulative strain produced at a cyclic stress ratio of 2 is about twice that at the cyclic stress …
Construction And Application Of Knowledge Graph For Quality Management In Bridge Pile Engineering, Fang Xiaofeng, Dong Runhao, Gu Yanke, Pan Yanran
Construction And Application Of Knowledge Graph For Quality Management In Bridge Pile Engineering, Fang Xiaofeng, Dong Runhao, Gu Yanke, Pan Yanran
Journal of China & Foreign Highway
To enhance the efficiency of quality management in bridge pile foundation construction,this study constructed a knowledge graph applicable to the construction field of bridge pile foundation engineering to enable systematic representation and intelligent organization of knowledge.A methodology combining top-down design and bottom-up design was adopted to develop a framework for constructing a knowledge graph for the quality management of bridge pile foundation construction that encompasses both the schema layer and the data layer.The schema layer was established through ontology modeling,clarifying the concept categories,hierarchical structure,and their attribute relationships.The data layer employed a bidirectional long short-term memory (BiLSTM ) network integrated with …
Twas-Ctl: A Robust And Efficient Method For Multi-Tissue Transcriptome-Wide Association Studies Using Cross-Tissue Learners, Md Mutasim Billah, Hairong Wei, Fengzhu Sun, Kui Zhang
Twas-Ctl: A Robust And Efficient Method For Multi-Tissue Transcriptome-Wide Association Studies Using Cross-Tissue Learners, Md Mutasim Billah, Hairong Wei, Fengzhu Sun, Kui Zhang
Michigan Tech Publications
The advent of transcriptome-wide association studies (TWAS) has expanded the classical genome-wide association study (GWAS) framework by integrating gene expression with genetic variation to identify trait-associated variants. While multi-tissue TWAS approaches improve statistical power over single-tissue models, existing methods often lose information during result aggregation and require intensive computation. Here, we present TWAS-CTL (Cross-Tissue Learner), a novel framework that leverages heterogeneous gene expression across tissues by adaptively reweighting and optimizing multiple single-tissue learners. Simulations demonstrate that TWAS-CTL achieves higher statistical power than the leading method, UTMOST, while maintaining proper type I error control and reducing computational time by over half. …
Model Inference And Sparse Network Analysis: Machine Learning In The Gene Regulatory Network Framework, Youchuan Wang
Model Inference And Sparse Network Analysis: Machine Learning In The Gene Regulatory Network Framework, Youchuan Wang
Dissertations - ALL
This thesis explores sparse network inference from high-dimensional, noisy, and underdetermined data—a fundamental challenge in many scientific domains. We focus on the development of evolutionary computation methods for discovering underlying network structures that are both interpretable and biologically plausible. Our methods are applied to the domain of Gene Regulatory Network (GRN) inference, where sparsity, indirect interactions, and limited observations pose significant hurdles. The framework models both steady-state and time-series gene expression data, with particular emphasis on biological sparsity and regulatory dynamics. We approach the problem from three perspectives: (1) edge-level analysis using transitive reduction to distinguish direct from indirect regulation; …
Enzyme Active Bath Affects Protein Condensation, Kevin Ching
Enzyme Active Bath Affects Protein Condensation, Kevin Ching
Dissertations - ALL
The idea that the activity of an active bath can act as an effective temperature and alter system behavior has been theorized and demonstrated for micron-scale systems, but it has not yet been shown for nanoscale systems. Previous studies have suggested that, although passive and active systems can be combined at the nanoscale, activity from the active system typically disrupts and destroys the passive system. In this work, I attempt to create an enzyme-driven active bath to control the liquid–liquid phase separation (LLPS) and condensation of a protein. I find that enzymatic activity enhances phase separation, effectively driving the LLPS …
Exploring The Chemical And Biological Foundations Of Protein Lipidation Through Functional And Computational Studies, Andrea Sprague-Getsy
Exploring The Chemical And Biological Foundations Of Protein Lipidation Through Functional And Computational Studies, Andrea Sprague-Getsy
Dissertations - ALL
Post-translational modifications (PTMs) are essential for the diversification of the human proteome. Prenylation is a PTM defined by the addition of a 15-carbon or 20 carbon isoprenoid group by FTase and GGTase-I, respectively, onto a cysteine near the C-terminus of proteins. This modification is the first step within the prenylation pathway where proteolysis and carboxymethylation occur afterwards, aiding in proteins localization to the cellular membrane. These prenyltransferases canonically recognize a “CaaX” box motif which has been determined through biochemical and structural studies. Recently, sequences following the C(x)3X and Cxx patterns have been shown to be prenylated as well as an …