Digital Commons Network^™

Synthesis Of Novel Aromatic Quinols For Colon And Renal Cancers, Bradley J. Davey, Tae Soo Jo, Pradip K. Bhowmik

Undergraduate Research Opportunities Program (UROP)

Colon Cancer: The third most common cancer in USA. More than 1 million Americans currently living with colon cancer. 148,810 new cases expected in 2010. 50,000 deaths annually.

Renal Cancer: Approximately 58,000 people diagnosed in USA annually. Seventh most common cancer and tenth most common cause of cancer related death in men.

Aromatic quinols have demonstrated in vitro antitumor activity. Three heteroaromatic quinols show antitumor activity.

Plant Sterol And Stanol Substrate Specificity Of Pancreatic Cholesterol Esterase, Andrew W. Brown, Jiliang Hang, Patrick H. Dussault, Timothy P. Carr

Patrick Dussault Publications

Consumption of plant sterols or stanols (collectively referred to as phytosterols) and their esters results in decreased lowdensity lipoprotein cholesterol, which is associated with decreased atherosclerotic risk. The mechanisms by which phytosterols impart their effects, however, are incompletely characterized. The objective of the present study is to determine if pancreatic cholesterol esterase (PCE; EC 3.1.1.13), the enzyme primarily responsible for cholesterol ester hydrolysis in the digestive tract, is capable of hydrolyzing various phytosterol esters and to compare the rates of sterol ester hydrolysis in vitro. We found that PCE hydrolyzes palmitate, oleate and stearate esters of cholesterol, stigmasterol, stigmastanol and …

Simulation Of Contaminant Transport From Solid Domestic Waste Disposal Sites In The Warri Deltaic Plain Sands, Warri-Effurun, Nigeria, Charles Onoriode Usiaphre

Theses, Dissertations and Culminating Projects

Protecting the groundwater resource in the Warri Deltaic Plain sand from the impact of anthropogenic contamination requires an understanding and knowledge of groundwater flow paths, transport processes and the source of contamination. This study was carried out to find out contaminant transport from solid domestic waste sites to the groundwater. The U.S. Geological Survey three-dimensional finite-difference code, MODFLOW, was used to simulate the groundwater flow. The flow pattern reveals predominantly downward flow, with major horizontal motion towards towns around Ekurede Urhobo and Ekurede Itsekiri in Warri. Simulation of advective contaminant transport using MODPATE1 for particle tracking indicates local movement of …

The Relationship Between The Level Of Support Group Participation And Psychosocial Factors In Prostate Cancer Patients Treated With Proton Therapy, Carol A. L. Davis

Loma Linda University Electronic Theses, Dissertations & Projects

Background. The role of support groups for cancer patients is known to be beneficial in helping people adjust to the disease, and cope with the myriad of effects that cancer has on quality of life. Although many people express interest in attending such support groups, few attend regularly. It is unclear what characteristics distinguish those who use such services from those who do not, especially among proton therapy patients.

Objective. To examine demographic and psychosocial characteristics associated with the Brotherhood of the Balloon (BOB) prostate cancer support group membership, a unique treatment-focused group originating at Loma Linda University Medical Center …

Chemical Modification And Biological Activity Exploration Of The Natural Product-Gossypol, Juanjuan Yin

All Dissertations

Gossypol is a naturally occurring, highly colored yellow pigment indigenous to the small intercellular pigment glands of the cotton plant genus Gossypium, which is proposed to be part of plant's defense system. Gossypol is characterized by wide contraceptive, antiviral, anticancer and antifungal properties. However, the relatively high toxicity of gossypol precludes its application in medical therapy. For this reason the syntheses and tests of gossypol derivatives, have been tried to enable their application as drugs. In our study, gossypol based methylation, glycosylation and nanoconjugate reactions were explored. The gossypol derivatives were all fully characterized by NMR, MS, FT-IR, UV spectrometry, …

In Vitro Enabling Technologies For Use In The Aquatic Environment, Colm J. O'Dowd

Doctoral

O’Dowd, C., Mothersill, C.E., Cairns, M.T., Austin, B., Lyng, F.M., McClean, B. and Murphy, J.E.J. Assessing the mitochondrion as a biomarker of fish tissue damage using g radiation as a stress model in vitro.

There is an ever-increasing need for biomarkers to identify toxic stress in the aquatic environment. Such techniques need to be accurate, expeditious, ethical and economical. Typically, in vitro based platforms fit these criteria however many of these systems often undergo ‘assay drift’ and consequently do not fully represent the real-life situation.

In recent years, there has been growing interest in the mitochondrion and its (dys)function …

Scwds Briefs: Volume 26, Number 2 (July 2010), Gary L. Doster , Editor, Scwds Briefs, Michael J. Yabsley

Southeastern Cooperative Wildlife Disease Study: Publications

Geese as Sentinels for AIV

Feral Swine Issues Survey

A Spate of Footrot

Some Recent SCWDS Awards

Some Worthwhile Causes
Tom Thorne & Beth Williams Memorial Fund
Ed Couvillion Scholarship Fund
Southeastern Wildlife Health Development Fund

Personnel Changes

Recent SCWDS Publications Available

Microzooplankton Grazing And Productivity In The Central And Southern Sector Of The Indian River Lagoon, Florida, Jennifer Putland, Tracey Sutton

Marine & Environmental Sciences Faculty Articles

Microzooplankton grazing was measured with the dilution method in the central and southern sectors of the Indian River Lagoon during summer 2006 and 2007. Microzooplankton actively grazed phytoplankton during all experiments. Grazing rates averaged (± SD) 0.956 ± 0.19 d^-1 and ranged from 0.54 to 1.36 d^-1. Phytoplankton carbon, measured by microscopy, averaged 314 ± 251 μg C L^-1 and ranged from 115 to 936 μg C L^-1. Microzooplankton ingestion rates averaged 303 ± 260 μg C L^-1d^-1 and ranged from 90 to 907 μg C L^-1d^-1. …

Hiv And Hepatocellular And Esophageal Carcinomas Related To Consumption Of Mycotoxin-Prone Foods In Sub-Saharan Africa, Jonathan H. Williams, Jessica A. Grubbs, Jerry W. Davis, Jia-Sheng Wang, Pauline E. Jolly, Nii-Ayi Ankrah, William O. Ellis, Evans Afriyie-Gyawu, Natalie M. Johnson, Abraham G. Robinson, Timothy D. Phillips

Environmental Health Sciences: Faculty Publications

Background: Promotion of the HIV epidemic by aflatoxin is postulated but not yet established. Sub-Saharan populations commonly consume food contaminated by mycotoxins, particularly aflatoxins (predominantly found in peanut, maize, rice, and cassava) and fumonisins, which occur primarily in maize. Aflatoxin promotes hepatocellular cancer, and fumonisin may promote esophageal cancer.

Objectives: This analysis was undertaken to test the hypotheses that consumption of mycotoxin-prone staple foods is 1) related to the incidence of HIV infection in Africa and 2) related to “signature” cancer rates confirming exposure to aflatoxins and fumonisins.

Design: World Health Organization data for causes of death and the Food …

Limnological Assistance For Lake Mead National Recreation Area: Quarterly Report, Period Ending June 30, 2010, Margaret N. Rees

Limnological Studies

Project 1

• Technical assistance with the implementation of the Interagency Monitoring Action Plan (I-MAP) for Quagga Mussels is ongoing. During this quarter, analysis was completed for 14 adult/juvenile samples from the fall 2009 – spring 2010 sampling.
• Sampling for the first of two small-scale research projects funded by this task agreement (Abundance and settlement at different depths of Lake Mead) was initiated on June 16, 2010.

Project 2

• Topics and proposed analyses have been drafted for annual report development as prescribed by the Plan.
• A plan for developing and organizing NPS limnology-related web pages has been documented and content has …

Management And Control Plan For Zinfandel Vines In South Paso Robles, Ca., Tanner E. Campbell

Earth and Soil Sciences

Zinfandel, also known as Zin, is a red skinned variety of wine grape very popular in California. The wines produced from Zinfandel grapes have an intense fruitiness and luscious texture. Production is extremely variable throughout California and is dependent upon, climate, soil fertility, crop level management practices, and irrigation. This study was conducted to determine the on site soil physical and chemical properties as a means to obtain optimal yields and fruit quality. The A & L Western Agriculture Laboratories performed comprehensive fertility analysis to determine the concentrations of the plant essential nutrients, organic matter, electrical conductivity, cation exchange capacity, …

Investigating Relationships In The Flash Pilot Study For Stride, Mathew R. Adams, Katrina J. Jackson, Andrew J. Zbin

Statistics

No abstract provided.

Comparing Observations Of Age At First Reproduction In Western Gray Whales To Estimates Of Age At Sexual Maturity In Eastern Gray Whales, Amanda L. Bradford, David W. Weller, Aimée R. Lang, Grigory A. Tsidulko, Alexander M. Burdin, Robert L. Brownell Jr.

United States Department of Commerce: Staff Publications

Age at first reproduction (AFR) is a basic component of age-structured whale assessment models, but direct estimates of this parameter do not exist for either the abundant eastern or critically endangered western population of gray whales (Eschrichtius robustus). Instead, assessments of both populations have utilized either of two recognized estimates of eastern gray whale age at sexual maturity (ASM) that are adjusted by a year to account for fetal gestation. These ASM estimates are: 1) 9 years median, 6-12 years range, and 2) 6 years median, 5-9 years range, but there are biases and discrepancies associated with these …

Effects Of Recycled Water On Landscape Plants, Casey R. Miranda

Master's Theses

ABSTRACT EFFECTS OF RECYCLED WATER ON LANDSCAPE PLANTS Casey Ray Miranda Recycled water is water that has been previously used, has suffered a loss of quality, and has been properly treated for redistribution (Wu et al. 2001). The use of recycled water as an alternative to fresh water in the landscape can have positive and negative effects. Experimentation on 40 different plant species during a 32 week period (2 phases of 16 weeks), was conducted to analyze the effects of recycled water irrigation on the appearance of landscape plants. Each species of plant was planted into 10 individual number 2 …

Poisonous Rangeland Plants In San Luis Obispo County, Sara Litten, Amanda Ou

Animal Science

Poisonous Rangeland Plants in San Luis Obispo County is a comprehensive educational guide to rangeland plants that are toxic to domestic livestock. This guide begins with an exploration of how the biological systems are affected by the poisonous plant toxins. The biochemistry behind these toxins is included in the discussion. Next, reference material for fourteen plants that inhabit San Luis Obispo County is provided. This information includes specific toxins found in poisonous plants, affected animals, symptoms of poisoning, stages of growth, lethal dose, and distribution of the plant in California. This section of the guide is filled with helpful photos …

Why Don’T Rats And Mice Vomit? A Behavioral And Anatomical Investigation, C. C. Horn, National Wildlife Res. Ctr, G.R. Gathright, B. Yates, P.L. Andrews

United States Department of Agriculture Wildlife Services: Staff Publications

Laboratory rats and mice are known to lack a vomiting response and the dimensions of the abdominal esophagus might be an important constraint (Andrews, 1995, Physiol. Zool.). However, a broad evaluation of Rodentia is lacking. Here we determined the behavioral responses and esophageal and diaphragm anatomy from 4 of the 5 Suborders.Weused prototypical emetic agents, apomorphine (s.c.), veratrine (s.c.), and copper sulfate (i.g.), which are thought to produce emesis by action on the area postrema, nodose ganglia, and vagal afferent fibers, respectively. None of the rodents, including nutria (Myocastor coypus), beavers (Castor canadensis), mountain beavers …

Are Biotechnology And Sustainable Agriculture Compatible?, David E. Ervin, Leland L. Glenna, Raymond Adelard Jussaume

Economics Faculty Publications and Presentations

Agricultural biotechnology has been largely opposed by advocates in the sustainable agriculture movement, despite claims by the technology’s proponents that it holds the promise to deliver both production (economic) and environmental benefits, two legs of the sustainability stool. We argue in this paper that participants in this polarized debate are talking past each other because assumptions about biotechnology and sustainability remain simplistic and poorly defined. Genetically engineered (GE) herbicide-resistant and insect-resistant crop varieties are the most visible current forms of agricultural biotechnology, and thus the form of biotechnology that many in the sustainability movement react to. However, these crops represent …

Food Delivery Footprint: Addressing Transportation, Packaging, And Waste In The Food Supply Chain, Madeleine E. Pullman, Robin Fenske, Wayne Wakeland

Business Faculty Publications and Presentations

Transportation of food accounts for a significant fraction of the carbon dioxide emissions believed to be adversely impacting climate and the environment. And this impact is increasing as food supply chains become longer and more complex, and food packaging requirements lead to increased waste. Many organizations such as hospitals and upper level education are becoming increasingly concerned about sustainability. In this study, college, university, and hospital food purchasing behavior were assessed using interviews, surveys, and modeling to evaluate the environmental implications of decisions regarding food transportation and packaging. Current purchasing practices, corresponding transportation modes, packaging, recycling, and waste removal were …

Mississippi Canyon 252 Incident Nrda Tier 1 For Deepwater Communities, Gregory Boland, Gary Brewer, Erik Cordes, Amanda Demopoulos, Chuek Fisher, Chris German, Ken Sulak

United States Geological Survey: Staff Publications

The northern Gulf of Mexico (GOM) is geologically diverse basin, described as the most complex continental slope region in the world. Regional topography of the slope consists of basins, knolls, ridges, and mounds derived from the dynamic adjustments of salt and the introduction of large volumes of sediment over long time scales. More than 99% of the sea floor in the GOM consists of soft sediment made up of various mixtures of primarily silt and clay. These wide-spread soft bottom communities are described in reports from major MMS studies by Gallaway et al. (1998) and Rowe and Kennicutt (2009). Relative …

New York Botanical Garden Internship: From Photography To Policy, Christine Willeford

Student Theses 2001-2013

No abstract provided.

Interview With Judy Combs, Kaiser Permanente, 2010 (Audio), Judy Combs

All Sustainability History Project Oral Histories

Interview of Judy Combs by Nazer Frias at Clackamas, Oregon on May 17th, 2010.

The interview index is available for download.

Preferential Fish Consumption Based On Omega-3 Fatty Acids And Mercury Concentrations For Maximum Health Benefits, Katrina Smith

Honors Theses

The regular consumption of seafood offers a variety of protective effects, including the reduction of the risk of cardiovascular disease and stroke, due to the presence of omega-3 fatty acids in fish. These protective effects may be diminished by the contamination of seafood by mercury. Mercury increases the risk of cardiovascular problems and impedes neurological development. The objective of this project was to determine the fish species that are appropriate for consumption based on low levels of mercury and recommended intake levels of omega-3 fatty acids. Species that are high in omega-3s and low in mercury include salmon, trout and …

Assessing Commercial Organic And Conventionally Grown Vegetables By Monitoring Selected Heavy Metals Found In Them., Charles Kafui Dotse

Electronic Theses and Dissertations

Commercially available organic and conventionally grown vegetables were studied by quantitative determination of selected metals in them and to determine if any differences found are statistically significant. These findings can help the consumers to determine if the vegetable products are within the recommended maximum limits as proposed by the joint FAO/WHO Expert committee on organic foods designation. Eight edible vegetables were purchased from local stores in both the organic and conventionally grown categories. Samples were digested with concentrated nitric acid and the metals monitored were zinc, copper, lead, iron, cadmium, and nickel using flame atomic absorption. The concentration range for …

The Homestead: Revisited, Christopher William Kramer

Masters Theses, 2010-2019

This paper discusses ideas for harmony on 100 acres in mid-eastern New York. Problems leading to this research include the depletion of resources from irresponsible energy use and profit-driven industrial agriculture; dependency on fossil fuels and centralized energy; and lack of connection between people within communities, with their environment, and with sources of food and water. It is feared that sustainable, resilience building practices that nourished generations throughout history are being neglected. This specific application provides depth and concreteness to the discussion and planning process. Resources including books, maps, reports, and periodicals were integrated to select the site and plan …

Production And In Vitro Investigation Of Vitamin B12-Based Bioprobes, Amy Rabideau

Renée Crown University Honors Thesis Projects - All

Vitamin B₁₂ (B₁₂)-based bioprobes were produced and investigated in vitro for studying the B₁₂ uptake pathway in certain cancer cell lines and their target-specific capabilities as imaging and/or contrast agents in vivo. An intrinsic factor (IF)-bound B₁₂ conjugate (B₁₂-ReBQBA) was produced containing rhenium(I) for in vitro analysis of the cubilin-expressing placental choriocarcinoma cell line. B₁₂-ReBQBA has millimolar toxicity in vitro and excitation and emission wavelengths in the visible region, 488 nm and 560 nm, respectively. The rhenium metal in this bioprobe can be readily exchanged for the metastable radioactive metal technetium-99m …

Creating A Biomedical Ontology Indexed Search Engine To Improve The Semantic Relevance Of Retreived Medical Text, William Taylor Ii

All Dissertations

Medical Subject Headings (MeSH) is a controlled vocabulary used by the National Library of Medicine to index medical articles, abstracts, and journals contained within the MEDLINE database. Although MeSH imposes uniformity and consistency in the indexing process, it has been proven that using MeSH indices only result in a small increase in precision over free-text indexing. Moreover, studies have shown that the use of controlled vocabularies in the indexing process is not an effective method to increase semantic relevance in information retrieval.
To address the need for semantic relevance, we present an ontology-based information retrieval system for the MEDLINE collection …

Time To Get Real: A Food Assessment Of Dining At Pomona College, Samantha Meyer

Pomona Senior Theses

Pomona College is an institution deeply committed to sustainability and student well being; however these commitments are not reflected in the College’s food purchases. Before this study, an assessment of purchasing had not been conducted at Pomona College. Using the Real Food Calculator – a metric designed to evaluate food purchasing at academic institutions – I tracked all food purchased by one of the College’s dining halls over the course of one month. Each food item was assessed based on the potential health concerns of its ingredients and whether the item was locally produced, ecologically sound and/or humane to determine …

A Mathematical Model Of The Biofluidmechanics Of The Non-Newtonian Mucus Layer Of The Tear Film In The Human Eye, Douglas M. Platt

Theses, Dissertations and Culminating Projects

The human eye is a complicated and delicate organ. The structure of the eye is such that it provides for clear vision of the world. The cornea and conjunctiva at the front of the eye are avascular structures that require nutrients and moisture to be provided by the tear film. The tear film also provides for the removal of debris from the surface of the eye. The tear film has several layers: a lipid layer, an aqueous solution, and mucus. The optical clarity and structural uniformity of the tear film is maintained by the blinking motion of the eyelid. During …

A Study Of The Sustainability Of Wild Capture Salmon In The Pacific Northwest, Justin D. Hansen

Social Sciences

No abstract provided.

Full Issue: Vol. 64, Issue 2

Sci-Tech News

No abstract provided.