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Articles 151 - 180 of 10856
Full-Text Articles in Entire DC Network
Computational And Experimental Analysis Of Oleanolic Acid As An Allosteric Activator Of Sirt1, Emrah Sariyer, Eda Dokumacioğlu, Hati̇ce İskender
Computational And Experimental Analysis Of Oleanolic Acid As An Allosteric Activator Of Sirt1, Emrah Sariyer, Eda Dokumacioğlu, Hati̇ce İskender
Turkish Journal of Chemistry
Sirtuin 1 (SIRT1) is a member of the sirtuin protein family and the biological effects of SIRT1 encompass various areas such as the ageing process, metabolism regulation, and cellular stress response. SIRT1 activators are compounds that enhance the activity of SIRT1 enzyme. These activators can be natural or synthetic compounds and have the potential to provide health benefits by augmenting the biological effects of SIRT1. Oleanolic acid (OA) is a triterpenoid compound that has antiinflammatory, antioxidant, and glucose and lipid metabolism-regulating properties naturally found in many plants. The aim of the present study was to investigate the effect of OA …
Investigation Of The Enzyme-Inhibitory, Antibacterial, And Anticancer Properties Of Metal Phthalocyanines, Meryem Topal, Fevzi̇ Topal, Firat Yilmaz, Esra Bulut Atalay, Ümi̇t Muhammet Koçyi̇ği̇t, Emre Güzel
Investigation Of The Enzyme-Inhibitory, Antibacterial, And Anticancer Properties Of Metal Phthalocyanines, Meryem Topal, Fevzi̇ Topal, Firat Yilmaz, Esra Bulut Atalay, Ümi̇t Muhammet Koçyi̇ği̇t, Emre Güzel
Turkish Journal of Chemistry
In this study, the enzyme inhibitory, antibacterial, and anticancer activities of a phthalonitrile derivative and its metal phthalocyanines (Pcs; indium, zinc, copper, cobalt, and manganese; 1–6) were investigated. The cobalt and manganese Pcs were synthesized for the first time in this study. The inhibitory activities of the symmetric Pcs, which were expected to interact with acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) via their 4-(isopropylbenzyl)oxy substituents through host–guest interactions, were investigated. More selective inhibition of AChE than BChE was observed for these compounds. For AChE, CoPc was identified as the most potent inhibitor (IC50 = 14.81 nM), whereas for BChE, InPc was …
Uptake And Fate Of Silver And Zinc Engineered Nanoparticles In Maize Under Single And Binary Dosing Soil Ecosystems, Lei Xu, Qingbo Yang, Xingmao Ma, Honglan Shi, John Yang, Hu Yang, Samira Mahdi, Ying Wang, Young Shin Jun
Uptake And Fate Of Silver And Zinc Engineered Nanoparticles In Maize Under Single And Binary Dosing Soil Ecosystems, Lei Xu, Qingbo Yang, Xingmao Ma, Honglan Shi, John Yang, Hu Yang, Samira Mahdi, Ying Wang, Young Shin Jun
Chemistry Faculty Research & Creative Works
Recent agricultural applications of engineered metallic nanoparticles (ENPs) have raised concerns about their uptake and fate in plants. To understand this critical issue, this study investigated the fate and uptake of silver (Ag) and zinc oxide (ZnO) ENPs in maize (Zea mays L.) after single or binary ENP exposure in soil. Results indicated that both Zn and Ag elemental concentrations in roots increased with increasing ENP dosage. Ag NPs in the tissues were detected, but not Zn NPs. Ag NP concentration was 3 times higher in the roots than in the shoots at low Ag NP dosing, while Ag NP …
Impact Of Climate Change On Agricultural Production In The North China Plain And Adaption Strategies, Yanjun Shen, Ying Guo, Chuanwei Zhang, Yaning Chen
Impact Of Climate Change On Agricultural Production In The North China Plain And Adaption Strategies, Yanjun Shen, Ying Guo, Chuanwei Zhang, Yaning Chen
Bulletin of Chinese Academy of Sciences (Chinese Version)
Over the past century, global warming has posed significant challenges to the North China Plain (NCP), a core region for grain production, where resource-induced water scarcity now coincides with complex meteorological disasters. In recent years, the NCP has exhibited new climatic characteristics, notably the transition from a “warm-dry” to a “warm-wet” pattern accompanied by asymmetric warming, leading to an increased frequency of extreme events such as droughts, abrupt dry-flood alternations, and temperature extremes. These shifts pose a grave threat to regional grain stability. Currently, critical gaps remain in the understanding of the underlying disaster mechanisms, as well as in predictive …
Fairhiveframes-1k: A Public Fair Dataset Of 1265 Annotated Hive Frame Images With Preliminary Yolov8 And Yolov11 Baselines, Vladimir Kulyukin, Reagan Hill, Aleksey Kulyukin
Fairhiveframes-1k: A Public Fair Dataset Of 1265 Annotated Hive Frame Images With Preliminary Yolov8 And Yolov11 Baselines, Vladimir Kulyukin, Reagan Hill, Aleksey Kulyukin
Computer Science Faculty and Staff Publications
In precision apiculture, the portable digital camera is a cost-effective sensor for capturing hive images or videos used to quantify different colony variables. Openly accessible, well-annotated, interoperable cell-level image datasets are still the exception rather than the norm. This shortage constitutes a major barrier to AI-driven approaches aimed at automating image-based comb analysis. In this article, we present FAIRHiveFrames-1K, a publicly available dataset of 1265 annotated hive frame images (1920 × 1080 PNG) designed to facilitate research in AI-intensive image-based comb analysis automation. The dataset, derived from a 2013–2022 U.S. Department of Agriculture–Agricultural Research Service multi-sensor research reservoir, includes 124,669 …
Organic Synthesis Of A Hydrazine Functionalized Ammonium Compound For Improved Capture Of Aldehyde Metabolites From Exhaled Breath, Po'iu N. Burgo
Organic Synthesis Of A Hydrazine Functionalized Ammonium Compound For Improved Capture Of Aldehyde Metabolites From Exhaled Breath, Po'iu N. Burgo
Undergraduate Theses
Breath analysis has emerged as a non-invasive and inexpensive way to screen for respiratory diseases. This technique involves measuring concentrations of specific metabolites found in exhaled breath that serve as a biomarkers for disease. A subclass of volatile organic compounds called α,β-Unsaturated aldehydes, products of the lipid peroxidation mechanism, are underrepresented as biomarkers of lung cancer. These have been found to have relatively increased concentrations in the exhaled breath of lung cancer patients compared to a healthy patient. One of the reasons that these metabolites have been underreported is that the techniques used to measure and characterized exhaled metabolites do …
Molecular Adaptation Of Sweet Potato To Martian Soil Simulant: Insights From Mrna And Long Non-Coding Rna Analyses, Subramanyam Reddy Chinreddy, Karthik Chinnannan, Purushothaman Natarajan, Vaibhavi Patel, Gwonjin Lee, Manohar Chakrabarti, Padma Nimmakayala, Umesh K. Reddy
Molecular Adaptation Of Sweet Potato To Martian Soil Simulant: Insights From Mrna And Long Non-Coding Rna Analyses, Subramanyam Reddy Chinreddy, Karthik Chinnannan, Purushothaman Natarajan, Vaibhavi Patel, Gwonjin Lee, Manohar Chakrabarti, Padma Nimmakayala, Umesh K. Reddy
School of Integrative Biological & Chemical Sciences Faculty Publications
Introduction: Understanding how crops adapt to extraterrestrial environments is essential for sustainable space agriculture. Sweet potato (Ipomoea batatas), a nutritionally rich and stress-resilient crop, is a promising candidate for cultivation under Martian-like conditions, characterized by high salinity, heavy metal contamination, and poor water retention.
Objective: This study aimed to elucidate the molecular mechanisms underlying sweet potato adaptation to Martian soil analog conditions using Mars Global Simulant-1 (MGS-1).
Methods: Leaf, shoot, and storage root tissues of sweet potato grown in MGS-1 were subjected to RNA sequencing. Differentially expressed mRNAs and long non-coding RNAs (lncRNAs) were identified, and functional enrichment analyses were …
Advancing Cyclic Ion Mobility Mass Spectrometry For Structural Characterization, Isomer Discrimination And Gas-Phase Ion Chemistry, Sudam Shivaji Mane
Advancing Cyclic Ion Mobility Mass Spectrometry For Structural Characterization, Isomer Discrimination And Gas-Phase Ion Chemistry, Sudam Shivaji Mane
Theses and Dissertations
This dissertation focuses on the development and application of high-resolution ion mobility-mass spectrometry (IMS-MS) methodologies for gas-phase separation and structural characterization of small molecules, with particular emphasis on epimers, positional isomers, and protomers. In addition to structural separations, this work investigates fundamental aspects of gas-phase ion chemistry using IMS-MS in combination with collision-induced ion activation and dissociation techniques. Advanced separations were performed using cyclic traveling-wave ion mobility spectrometry (cyclic TWIMS), implemented in a commercial cyclic ion mobility-mass spectrometry (cIMS) platform, to systematically evaluate both the capabilities and limitations of high-resolution IMS in resolving subtle structural differences. Initial studies demonstrated that, …
Investigating The Effect Of Kcl Stress In Raphanus Sativus, Mason P. Oelke
Investigating The Effect Of Kcl Stress In Raphanus Sativus, Mason P. Oelke
ATU Scholars Symposium
Presented by Stephanie Nelms at the Arkansas INBRE Conference on November 7-8, 2025.
Presented by Mason Oelke at Arkansas Tech Scholar's Symposium on April 9th, 2026.
Potassium is an essential macronutrient for plant growth and development, yet excessive potassium fertilization can induce salt stress with detrimental consequences for crop productivity and nutritional quality. Despite its agricultural relevance, potassium chloride induced stress remains significantly understudied compared to classical sodium-based salinity. This thesis investigates the physiological, biochemical, and molecular responses of Raphanus sativus to KCl stress using an integrated approach that combines germination assays, mineral profiling, and gene expression analysis.
Radish seeds …
Reday Program 2026, Bryant University
Reday Program 2026, Bryant University
Bryant REDay (Research and Engagement Day)
Program for the 2026 Bryant REDay (Research and Engagement Day). Program includes schedule at a glance, descriptions for panels, workshops, and presentations, along with sign-up links for specific sessions in the electronic version of the program. Printed program was in color with double-sided printing on 8 1/2" x 11" paper stapled together in the upper left corner.
Psychosocial Mediators Of A Physical Activity And Dietary Intervention In Pregnant Women With Overweight Or Obesity, Meghan Baruth, Sarah Wilcox, Jihong Liu, Rebecca Schlaff
Psychosocial Mediators Of A Physical Activity And Dietary Intervention In Pregnant Women With Overweight Or Obesity, Meghan Baruth, Sarah Wilcox, Jihong Liu, Rebecca Schlaff
Faculty Publications
Background
Mediation analyses provide insight into both ‘pieces’ of the mediation chain; they allow us to look into the ‘black box’ that is behavior change. They allow researchers to better understand the ‘how’ of an intervention’s effects and/or the ‘why’ behind why an intervention worked or did not work. The lack of publications in pregnant populations highlights the need for additional studies to be conducted and published. The purpose of this study is to examine the psychosocial mediators of physical activity and dietary outcomes in a sample of pregnant women with overweight or obesity participating in the Health in Pregnancy …
Anti-Inflammatory And Insulin-Modulating Effects Of Tithonia-Curcuma-Moringa (Tcm) Formulation In Type 2 Diabetes: An Experimental Study In Mice, Rif’Atul Hawani Burhan, Nabila Shafa Yumna Salsabila, Devita Zulfa Pratama, La Tazkia Aulia Wibowo, Yulian Ervin Maulana, Moh Dliyauddin, Noviana Dwi Lestari, Agung Pramana Warih Marhendra, Aris Soewondo, Hideo Tsuboi, Muhaimin Rifa’I
Anti-Inflammatory And Insulin-Modulating Effects Of Tithonia-Curcuma-Moringa (Tcm) Formulation In Type 2 Diabetes: An Experimental Study In Mice, Rif’Atul Hawani Burhan, Nabila Shafa Yumna Salsabila, Devita Zulfa Pratama, La Tazkia Aulia Wibowo, Yulian Ervin Maulana, Moh Dliyauddin, Noviana Dwi Lestari, Agung Pramana Warih Marhendra, Aris Soewondo, Hideo Tsuboi, Muhaimin Rifa’I
Karbala International Journal of Modern Science
Type 2 diabetes is a chronic metabolic disorder characterized by hyperglycemia and chronic inflammation. This study investigated the anti-inflammatory and insulin-modulating effects of Tithonia-Curcuma-Moringa (TCM) formulation in type 2 diabetes model. Male BALB/c mice were divided into six groups: normal control, type 2 diabetes control, metformin treatment, and three TCM formulation treatment groups with three different dose combinations. Type 2 diabetes was induced using a high-fat diet combined with streptozotocin injection, supported by sucrose administration. After 21 days of treatment, the spleen and pancreas were isolated for flow cytometry analysis. The results showed that the expression levels of …
Dendrimer Nanogels With Built-In Free Radical Scavenging Enable Efficient Topical Delivery Of A Hydrophilic Antioxidant To Restore Lens Redox Balance For Cataract Treatment, Lin Qi, Huari Kou, Anna Chernatynskaya, Da Huang, Vimalin Jeyalatha Mani, Humeyra Karacal, Nuran Ercal, Hu Yang
Dendrimer Nanogels With Built-In Free Radical Scavenging Enable Efficient Topical Delivery Of A Hydrophilic Antioxidant To Restore Lens Redox Balance For Cataract Treatment, Lin Qi, Huari Kou, Anna Chernatynskaya, Da Huang, Vimalin Jeyalatha Mani, Humeyra Karacal, Nuran Ercal, Hu Yang
Chemistry Faculty Research & Creative Works
Cataract is a leading cause of vision impairment worldwide and are primarily caused by oxidative stress that damages and aggregates lens proteins, leading to lens opacification. However, the eye's anatomical barriers limit the penetration and bioavailability of antioxidant therapies. To address this challenge, a dendrimer-based nanogel with a built-in reactive oxygen species (ROS)-scavenging capability developed by us was employed to deliver the antioxidant N-acetylcysteine (NAC) to the lens. NAC was loaded into a generation-5 PEGylated poly(amidoamine) dendrimer (G5-PEG-TK, termed the GPT) nanogel. The resulting NAC-GPT was characterized for its ROS-scavenging activity, bioavailability, and corneal permeability. The efficacy of NAC-GPT was …
Efficacy Analysis In Clinical Trials: A Comprehensive Review Of Statistical And Machine Learning Approaches, Dhrubajyoti Ghosh, Samhita Pal
Efficacy Analysis In Clinical Trials: A Comprehensive Review Of Statistical And Machine Learning Approaches, Dhrubajyoti Ghosh, Samhita Pal
Faculty Articles
Efficacy testing is a cornerstone of clinical trials, ensuring that medical interventions achieve their intended therapeutic effects. Over the decades, a wide range of statistical methodologies have been developed to address the complexities of clinical trial data, including parametric, nonparametric, Bayesian, and machine learning approaches. Parametric methods, such as t-tests, ANOVA, and LMMs, have traditionally been the foundation of efficacy testing due to their efficiency under well-defined assumptions. Nonparametric techniques, including the Friedman test, Brunner-Munzel test, and modern extensions like nparLD, have emerged as robust alternatives, particularly for skewed, ordinal, or non-normal data. Bayesian methodologies have enabled the incorporation of …
Dissecting The Etiology Of Alcohol Use Disorder By An Integrative Heritable Component Approach, Ivy Garrenton
Dissecting The Etiology Of Alcohol Use Disorder By An Integrative Heritable Component Approach, Ivy Garrenton
Computer Science Theses & Dissertations
Alcohol Use Disorder (AUD) is a pervasive condition characterized by complex interplay among genetic, phenotypic, and environmental factors. Although previous studies have identi fied genetic loci associated with alcohol consumption, these efforts have not captured the genetic heterogeneity and gene-environment interactions underlying AUD pathogenesis. To address this critical gap, we developed a novel statistical methodology that integrates phenotypic, genotypic, and environmental data through an environmentally modified Genetic Relationship Matrix (GRM) to derive AUD-related traits with enhanced heritability.
This approach demonstrated superior performance in both simulated and real-world datasets. Traits derived using the environmentally modified GRM exhibited significantly higher estimated heritability …
Enhancing Urban Garden Capacity By Linking Biodiversity And Ecosystem Function, Mary T. Nguyen, Carleen Rauh, Shelby Gresch, Charlotte Correiro, Heidi Elmendorf, Adriane Fugh-Berman, Gina Wimp, Alexandra L. Decandia
Enhancing Urban Garden Capacity By Linking Biodiversity And Ecosystem Function, Mary T. Nguyen, Carleen Rauh, Shelby Gresch, Charlotte Correiro, Heidi Elmendorf, Adriane Fugh-Berman, Gina Wimp, Alexandra L. Decandia
Virginia Journal of Science
Urban agriculture broadly describes food and plant cultivation in metropolitan areas. While biodiversity is thought to support ecosystem health and resilience, the relationship between above-ground and below-ground diversity has been understudied in urban green spaces. This study examines plant, animal, bacterial, and fungal diversity across three distinct urban habitats: a turf lawn, a forb garden, and a farming space. Using bacterial 16S rRNA and fungal ITS2 sequencing, soil nutrient analyses, and surveys of vegetation and wildlife, we connect diverse philosophies in urban agriculture to their role in advancing community diversity and ecosystem function. We found that different urban gardens support …
Interspecific Overlap In Seabird Diet Throughout The Breeding Season, Alexis V. Berkey
Interspecific Overlap In Seabird Diet Throughout The Breeding Season, Alexis V. Berkey
Student Publications
Seabirds are central-place foragers that breed in multi-species colonies, providing an opportunity to study species coexistence. I quantified interspecific competition among four seabird species (common terns Sterna hirundo, Arctic terns Sterna paradisaea, Atlantic puffins Fratercula arctica, black guillemots Cepphus grylle) breeding in the Gulf of Maine in 2022, 2024, and 2025. I hypothesized that, throughout the breeding season, 1) seabird diet would change and 2) interspecific overlap in diet would increase. I compared diets across species and time using direct observation of prey feeds and stable isotope values of seabird egg membranes and blood, which provide …
Draft 2025 Butte Priority Soils Operable Unit Residential Metals Abatement Program Construction Completion Report, Abby Peltomaa
Draft 2025 Butte Priority Soils Operable Unit Residential Metals Abatement Program Construction Completion Report, Abby Peltomaa
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
Propaganda Ai: An Analysis Of Semantic Divergence In Large Language Models, Nay Myat Min, Long H. Pham, Yige Li, Jun Sun
Propaganda Ai: An Analysis Of Semantic Divergence In Large Language Models, Nay Myat Min, Long H. Pham, Yige Li, Jun Sun
Research Collection School Of Computing and Information Systems
Large language models (LLMs) can exhibit concept-conditioned semantic divergence: common high-level cues (e.g., ideologies, public figures) elicit unusually uniform, stance-like responses that evade token-trigger audits. This behavior falls in a blind spot of current safety evaluations, yet carries major societal stakes, as such concept cues can steer content exposure at scale. We formalize this phenomenon and present RAVEN (Response Anomaly Vigilance), a black-box audit that flags cases where a model is simultaneously highly certain and atypical among peers by coupling semantic entropy over paraphrastic samples with cross-model disagreement. In a controlled LoRA fine-tuning study, we implant a concept-conditioned stance using …
Patterns Of Multimorbidity Among Low-Income Adults Who Smoke With Implications For Tailored Interventions: A Cluster Analysis Using A Mixture Of Bernoulli Model, Monique T. Cano, Michael R. Lindstrom, Oscar F. Rojas Perez, Ricardo F. Muñoz
Patterns Of Multimorbidity Among Low-Income Adults Who Smoke With Implications For Tailored Interventions: A Cluster Analysis Using A Mixture Of Bernoulli Model, Monique T. Cano, Michael R. Lindstrom, Oscar F. Rojas Perez, Ricardo F. Muñoz
School of Mathematical & Statistical Sciences Faculty Publications
Introduction: Smoking cigarettes remains a leading modifiable risk factor for preventable health conditions. In the United States, the health burden of smoking disproportionately impacts low-income individuals. Multimorbidity is common in this group, complicating treatment and worsening outcomes. Identifying multimorbidity clusters can support targeted, individualized interventions. This study aimed to identify multimorbidity clusters among individuals who smoke and experience economic hardship and provide clinical recommendations to enhance health outcomes.
Method: Individuals who smoke and experience economic hardship (N = 60) were recruited from the San Francisco Health Network (SFHN) and were assessed for physical and mental conditions. Cluster analysis was …
Association Between The Dietary Index For Gut Microbiota (Di-Gm) And Colorectal Cancer In The Plco Cohort, Bezawit E. Kase, Angela D. Liese Ph.D., Jiajia Zhang Ph.D., Elizabeth Angela Murphy, Susan E. Steck Phd, Mph, Rd
Association Between The Dietary Index For Gut Microbiota (Di-Gm) And Colorectal Cancer In The Plco Cohort, Bezawit E. Kase, Angela D. Liese Ph.D., Jiajia Zhang Ph.D., Elizabeth Angela Murphy, Susan E. Steck Phd, Mph, Rd
Faculty Publications
Objectives: The study aimed to examine the association between a dietary index for gut microbiota (DI-GM) and the risk of incident colorectal cancer (CRC). Clarifying the role of diet-induced alterations in the composition and function of gut microbiota on the development of CRC can contribute to prevention efforts. Methods: Participants from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening trial enrolled in the intervention arm and who completed baseline assessments were included in the analysis (n = 55,685). The DI-GM is a literature-derived index used to score diet quality in terms of maintaining healthy gut microbiota. A time-dependent Cox model …
Association Between The Dietary Index For Gut Microbiota (Di-Gm) And Colorectal Cancer In The Plco Cohort, Bezawit E. Kase, Angela D. Liese, Jiajia Zhang, Elizabeth Angela Murphy, Susan E. Steck
Association Between The Dietary Index For Gut Microbiota (Di-Gm) And Colorectal Cancer In The Plco Cohort, Bezawit E. Kase, Angela D. Liese, Jiajia Zhang, Elizabeth Angela Murphy, Susan E. Steck
Faculty Publications
Objectives: The study aimed to examine the association between a dietary index for gut microbiota (DI-GM) and the risk of incident colorectal cancer (CRC). Clarifying the role of diet-induced alterations in the composition and function of gut microbiota on the development of CRC can contribute to prevention efforts. Methods: Participants from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening trial enrolled in the intervention arm and who completed baseline assessments were included in the analysis (n = 55,685). The DI-GM is a literature-derived index used to score diet quality in terms of maintaining healthy gut microbiota. A time-dependent Cox model …
Soil Microbial Biomass And Organic Carbon Fractions Under Different Natural Restoration Years In Arid Coal Mining Subsidence Areas In Xinjiang, China, Xiao Li, Bi Yinli, Wang Dongdong, Li Jianfeng, Gong Hanlin, Deng Aojuan, Hou Wensheng
Soil Microbial Biomass And Organic Carbon Fractions Under Different Natural Restoration Years In Arid Coal Mining Subsidence Areas In Xinjiang, China, Xiao Li, Bi Yinli, Wang Dongdong, Li Jianfeng, Gong Hanlin, Deng Aojuan, Hou Wensheng
Coal Geology & Exploration
Objective This study aims to elucidate the influence of the natural restoration process on changes in soil microbial biomass and organic carbon fractions in coal mining subsidence areas. This effort will provide a crucial scientific foundation for understanding the natural ecological restoration process and carbon accumulation dynamics in arid coal mining subsidence areas.Methods Arid coal mining subsidence areas in Xinjiang, China were investigated in this study. Using the space-for-time substitution approach, sample plots were selected from an unmined area and areas having undergone natural restoration for one, three, eight, and 12 years. Subsequently, systematic analyses were conducted on the …
What Does Next-Generation Mass Spectrometry Offer For Proteomics? A Comprehensive Platform Comparison, Filipa Blasco Tavares Pereira Lopes, Daniela Schlatzer, Tara Sudhadevi, Anantha Harijith, Marzieh Ayati, Mehmet Koyutürk, Mark R. Chance
What Does Next-Generation Mass Spectrometry Offer For Proteomics? A Comprehensive Platform Comparison, Filipa Blasco Tavares Pereira Lopes, Daniela Schlatzer, Tara Sudhadevi, Anantha Harijith, Marzieh Ayati, Mehmet Koyutürk, Mark R. Chance
Computer Science Faculty Publications
Next-generation mass spectrometry platforms (Orbitrap Astral, timsTOF Ultra) are reshaping proteomics by enhancing analytical depth and sensitivity. We compared these platforms against Orbitrap Exploris 480 using neonatal mouse lung tissues from a bronchopulmonary dysplasia model (n = 12), employing four acquisition strategies: Exploris 480 DDA/DIA, Astral HR-DIA, and timsTOF Ultra DIA-PASEF. All platforms identified ∼4000 proteins in common, with 98% proteome coverage of data-dependent acquisition (DDA) identifications using data-independent (DIA) methods and 92% concordance between next-generation systems. Orbitrap Astral and timsTOF Ultra quantified >225,000 peptides and 13,000 proteins, representing ∼800% and ∼300% greater depth than Exploris 480 DDA, respectively. …
Dietary Inflammatory Index And Objective Disease Activity In Ibd: No Association Found, Rúbia Moresi Vianna De Oliveira, Ana Carolina Junqueira Vasques, Stefhani Andrioli Romero, Nitin Shivappa Mbbs, Mph, Ph.D., Michael David Wirth, James Hébert Scd, Glaucia Fernanda Soares Ruppert Reis, Cristiane Kibune Nagasako
Dietary Inflammatory Index And Objective Disease Activity In Ibd: No Association Found, Rúbia Moresi Vianna De Oliveira, Ana Carolina Junqueira Vasques, Stefhani Andrioli Romero, Nitin Shivappa Mbbs, Mph, Ph.D., Michael David Wirth, James Hébert Scd, Glaucia Fernanda Soares Ruppert Reis, Cristiane Kibune Nagasako
Faculty Publications
Background
Inflammatory Bowel Disease (IBD) involves genetic and environmental factors, but the relationship between disease activity, adiposity, and diet remains unclear.
Objective
To investigate the association between endoscopic/radiological activity of IBD, body adiposity, and the Dietary Inflammatory Index with or without adjustment for energy density (E-DII or DII).
Method
An observational, cross-sectional study was carried out. Endoscopic activity was defined by an endoscopic Mayo score >2, Crohn’s Disease Endoscopic Index of Severity (CDEIS) > 5, and/or the presence of a deep ulcer in any intestinal segment. Body adiposity was estimated using the body mass index, waist circumference, and waist-hip ratio (WHR). …
Circulating Levels Of Insulin-Like Growth Factor I (Igf-I) And Risk Of Multiple Myeloma: An Observational And Mendelian Randomisation Study, Yolanda Benavente, Sara Hermosa, Nikos Papadimitriou, Alyssa I. Clay-Gilmour Ph.D., Elizabeth E. Brown, Jonathan N. Hofmann, Nathaniel Rothman, Qin Lan, Sonja I. Berndt, Demetrius Albanes, Mark Purdue, Mitchell J. Machiela, Stephen J. Chanock, Parveen Bhatti, Wendy Cozen, Aaron Norman, Susan L. Slager, James R. Cerhan, Vincent Rajkumar, Et. Al.
Circulating Levels Of Insulin-Like Growth Factor I (Igf-I) And Risk Of Multiple Myeloma: An Observational And Mendelian Randomisation Study, Yolanda Benavente, Sara Hermosa, Nikos Papadimitriou, Alyssa I. Clay-Gilmour Ph.D., Elizabeth E. Brown, Jonathan N. Hofmann, Nathaniel Rothman, Qin Lan, Sonja I. Berndt, Demetrius Albanes, Mark Purdue, Mitchell J. Machiela, Stephen J. Chanock, Parveen Bhatti, Wendy Cozen, Aaron Norman, Susan L. Slager, James R. Cerhan, Vincent Rajkumar, Et. Al.
Faculty Publications
No abstract provided.
Institutional And Ideational Features Of Canadian-Us Fishery Management Networks: Connectivity, Coherence, And Collaboration, Owen Temby, Evelyn Roozee, Dongkyu Kim, Jasper R. De Vries, Derek A. Katznelson, Antonia Sohns, Gordon M. Hickey
Institutional And Ideational Features Of Canadian-Us Fishery Management Networks: Connectivity, Coherence, And Collaboration, Owen Temby, Evelyn Roozee, Dongkyu Kim, Jasper R. De Vries, Derek A. Katznelson, Antonia Sohns, Gordon M. Hickey
School of Earth, Environmental, & Marine Sciences Faculty Publications
This article examines fishery management along and across the Canadian-US border through the comparison of collaborative transboundary networks in four regions: the Salish Sea, the Great Lakes, the Gulf of Maine, and the northern region including the Gulf of Alaska and the Hecate Strait. Transnational fishery management is an inter-organizational and multi-jurisdictional enterprise constituted by shared understandings of a suite of tasks and by communications among the participants. We use survey data to summarize the inter-organizational scale and participation in the networks, the centrality of different organization types, the factors that contribute to network formation, other ideational network traits like …
Water Sources And Livelihood Choices Among Pastoralist Households In Monduli District, Tanzania, Fredrick Alleni Mfinanga, Jacqueline Temba, Monica F. Timbuka
Water Sources And Livelihood Choices Among Pastoralist Households In Monduli District, Tanzania, Fredrick Alleni Mfinanga, Jacqueline Temba, Monica F. Timbuka
Journal of Humanities and Social Sciences
This paper investigates the association between types of water sources for livestock and livelihood choices of pastoralist households in semi-arid areas of Monduli District, Tanzania. Specifically, it aims to examine the influence of the types of water sources for livestock on livelihood diversification of pastoralist households. Using a mixed research methods approach, the data were collected from 367 households through three methods: surveys, interviews, and focus group discussions. The quantitative data were analysed using descriptive statistics such as frequencies and counts, and inferential statistics, Chi-square tests and correlation, while the qualitative data were analysed using content analysis. The findings revealed …
Resilience Among Smallholder Irish Potato Farmers To The Impacts Of Climate Variability In Wanging’Ombe District, Tanzania, Timotheo Bilary Ngalaga, Digna Wolfram Mlengule, Jackson Raymond Sawe
Resilience Among Smallholder Irish Potato Farmers To The Impacts Of Climate Variability In Wanging’Ombe District, Tanzania, Timotheo Bilary Ngalaga, Digna Wolfram Mlengule, Jackson Raymond Sawe
Journal of Humanities and Social Sciences
This paper examines smallholder farmers’ adaptation strategies to climate variability, and their resilience in enhancing their capacity to adopt. The data was collected from 98 heads of households using both quantitative and qualitative approaches. The methods of data collection included household surveys, focus group discussions (FGDs), in-depth interviews, and document review. The quantitative data were analysed using the IBM SPSS (Version 23), while the qualitative data were analysed using thematic analysis. The findings indicate that 69.4% of respondents reported a decrease in rainfall, while 89.8% reported an increase and fluctuations in temperature over the past 29 years. Moreover, the findings …
On Edible Food Recovery: Integration Of Local Agriculture Into Santa Clara County Food Recovery Networks, Anna Keenan, Caitlin Delamora, Jenna Martinez, Vansh Malik
On Edible Food Recovery: Integration Of Local Agriculture Into Santa Clara County Food Recovery Networks, Anna Keenan, Caitlin Delamora, Jenna Martinez, Vansh Malik
Environmental Studies and Sciences Senior Capstone
Santa Clara County (SCC) produces over 50 million pounds of surplus food, yet 31% percent of county residents are reported to be at risk of food insecurity, lacking reliable access to proper, affordable nutrition. Additionally, SCC produces approximately 40,000 tons of food waste annually. Food waste decomposes in landfills, producing greenhouse gas emissions, posing a pressing public health and environmental issue. California’s food waste law (SB 1383) addresses this challenge. We aimed to provide actionable insights that enable local farmers to donate more surplus produce, identifying ways to divert food loss from local farms to recovered food hubs, turning potential …