The Study Of Hydrophobic Biomolecules With Matrix Assisted Laser Desorption Ionization Mass Spectrometry And Atomic Force Microscopy, Brandy L. Perkins

LSU Doctoral Dissertations

Abstract

Matrix assisted laser desorption ionization (MALDI) mass spectrometry (MS) can be used to obtain localization and chemical information of hydrophobic biomolecules on tissue samples.  A technique has been developed to modify a standard MALDI matrix that improves the selectivity for hydrophobic biomolecules on the tissue sample. The modification involves the use of a Group of Uniform Materials Based on Organic Salts (GUMBOS). GUMBOS are ionic liquids (IL) that are bulky organic ions with a counter ion that can be changed for tuning.  They are more stable than traditional matrices under vacuum.  Unlike traditional IL’s, the GUMBOS melting point ranges …

A Visitation Grid For Complete Coverage Foraging In Robot Swarms, Arturo Gonzalez, Yifeng Gao, Li Zhang, Qi Lu

Computer Science Faculty Publications

The complete collection of sparse resources in large, unknown environments remains a challenging problem for autonomous robot swarms. Previous studies have shown that a substantial portion of total mission time is consumed during the final stage of collection, where only a small fraction of randomly scattered resources remain. Consequently, many existing swarm foraging algorithms (search and collection) focus on collecting most resources within a limited time window, rather than improving end-stage efficiency for collecting all resources. We propose a grid-based stochastic foraging strategy that explicitly reduces redundant visits and accelerates late-stage collection. The unknown search area is partitioned into a …

Governance, Culture, And Law: The Expanding Scope Of Environmental Science And Sustainable Development Research, Ahyaudin Sodri, Herdis Herdiansyah

Journal of Environmental Science and Sustainable Development

Environmental science emerged as a discipline based on physical measurements, such as soil pollutant levels (Ailijiang et al., 2022), ecological restoration (Yue et al., 2026), city surface temperature (Shafizadeh-Moghadam et al., 2025), and microbial density in air samples (Hayleeyesus & Manaye, 2014). However, its objects of study increasingly extend beyond the confines of the laboratory. Questions that were once sufficiently answered with measurement data now require answers through draft laws, Constitutional Court decisions, financial reports of mining companies, and even traditional ritual discourses governing community access to forests. In other words, environmental …

Sums Of Consecutive Integers And Sequence Of Divisors, Mushrat Fatema, Abdulkadir Hassen

STEM Student Research Symposium Posters

This work is concerned with two problems in number theory. The first part is to find the maximum number of sequence of integers such that two consecutive numbers in the list are multiple or factor of the other, and integers that can be expressed as a sum of consecutive integers.

Attention-Based Ensemble Deep Learning Model For Arabic And English Fake News Classification, Ameer Alhaq Alshamery

Journal of Intelligent Informatics, Networking, and Cybersecurity

It is difficult to classify articles as fake news since one article may consist of true facts with only some statements being fake. Moreover, classification becomes complicated for the Arabic language owing to its morphology and several ways of spelling, as well as the lack of well-classified and marked data sets. This paper presents an Ensemble Deep Learning Model (EDLM) used for Arabic and English fake news classification. The EDLM consists of CNN, Bi-LSTM with attention, and Bi-GRU with attention networks. Each of them produces one probability of the article, which is then summed up to a final probability via …

Bridging The Gap In Science Research: Preparing Students For College- Level Research In The Sciences, Victoria Helwig, Yaoguang Li

UConn Library Presentations

Many first-year students enter college unprepared to fully engage with scientific literature and academic library resources. Drawing on experiences from academic librarians working with STEM students, this session explores common gaps in science research skills, including navigating databases, identifying scholarly sources, and understanding the structure of scientific literature. Participants will be introduced to practical strategies and classroom-ready activities to better prepare students for college-level research. Discussion questions: What science research skills do students struggle with most when entering college? How can high school instruction better support these skills? Where can librarians and educators collaborate to support student success?

Environmental Dna For Endangered Freshwater Mussel Monitoring: A Review On Global Synthesis Of Edna Methods, Challenges, And Innovative Strategies, Mizanur Rahman, Md. Saydur Rahman, Richard J. Kline

School of Earth, Environmental, & Marine Sciences Faculty Publications

Freshwater mussels (family Unionidae) are among the most endangered aquatic species worldwide, making effective monitoring vital for their conservation. Traditional surveys are laborious, time-consuming, and often miss rare or low-density populations. Environmental DNA (eDNA) is a highly sensitive, non-invasive approach for freshwater mussel detection and monitoring; however, uncertainties in ecological interpretation continue to limit its broader application in freshwater biodiversity monitoring. We conducted a systematic review of 49 peer-reviewed studies, identified through an extensive literature search, to assess temporal research trends, methodological advancements, ecological contexts, and regulatory readiness of freshwater mussel eDNA monitoring. Findings show that freshwater mussel eDNA research …

A Data-Driven Framework For Mitigating Breast Cancer Overdiagnosis: From Estimation To Risk-Adjusted Computer-Aided Diagnosis, William M. Brown Jr.

LSU Doctoral Dissertations

In Computer-Aided Diagnosis (CAD) of cancer, standard cost metrics (false-positives and false-negatives) fundamentally fail to account for overdiagnosis. Overdiagnosis is a critical scenario where a disease is correctly detected (true-positive) but is biologically indolent and would never have caused the patient harm or symptoms. While widely recognized in the medical community as a major healthcare crisis driving stressful and invasive overtreatment, overdiagnosis remains severely under-researched within computer science and engineering. This dissertation addresses this interdisciplinary gap by defining the three key computational challenges of overdiagnosis: (i) accurate estimation, (ii) harm quantification, and (iii) algorithmic mitigation. To overcome the estimation challenge, …

A Mathematical Decision-Making Framework For Athlete Development In A Collegiate Taekwondo Community: Prioritizing Coaching Interventions Using Statistical Analysis And The Analytic Hierarchy Process, King Harold A. Recto, Hazel Jade L. Antonio, Jhyrald Anthony P. Dalida

Electronics, Computer, and Communications Engineering Faculty Publications

Athlete development within collegiate sports communities requires informed decisions regarding the prioritization of coaching interventions and allocation of developmental resources. However, such decisions are frequently guided by experience and intuition, limiting opportunities for systematic and evidence-based decision-making. This study develops a mathematical decision-making framework for athlete development by integrating statistical analysis and the Analytic Hierarchy Process (AHP) within a collegiate taekwondo community. Data were collected from 25 collegiate taekwondo athletes who satisfied established eligibility criteria, including participation in University Athletic Association of the Philippines (UAAP) competitions during the previous three seasons. Athletes evaluated coaching practices across five dimensions: Training and …

Effects Of O-Glcnacylation And Phosphorylation On Tau Aggregation By Cd And Tem, Andrew Whyte Jr.

Electronic Theses and Dissertations 2020 - Present

Alzheimer’s disease (AD) is characterized by the accumulation of extracellular amyloid-β (Aβ) plaques and intracellular neurofibrillary tangles composed of aggregated tau protein. Among the numerous post-translational modifications that regulate tau function, phosphorylation and O-GlcNAcylation have emerged as key modulators of tau aggregation and pathology. While phosphorylation is generally associated with tau misfolding and fibril formation, O-GlcNAcylation has been proposed to exert protective effects through its interplay with phosphorylation. However, the site-specific structural consequences of these modifications remain incompletely understood.

The objective of this work was to develop synthetic tools for the site-specific incorporation of O-GlcNAc and phosphate …

Understanding The Long-Run Effect Of Historical Redlining Practices, Yujian Lu

Geography ETDs

Historical redlining practices initiated by Home Owners’ Loan Corporation (HOLC) in the 1930s have produced enduring persistent socioeconomic and environmental disparities in U.S. cities. This dissertation examines their long-term impacts on social vulnerability, urban flood risk, along with public discourse about redlining practices. Results indicate that neighborhoods with HOLC grade A (greenlined) exhibit the lowest overall social vulnerability, while those graded D (redlined) face the highest across U.S. cities. In Chicago, associations between redlining practices and flood risk disparities are stronger than in Los Angeles, reflecting place-specific characteristics among environmental, socioeconomic, and demographic factors shaping flood risk disparities in long …

How Forest Structure And Climate Influence Snowpack For Water Resources In The Southwestern United States, Lindsey L. Rotche

Geography ETDs

Climate change, declining snowpack, and increasing wildfire risk have profound impacts on water availability in the southwestern United States. Because the southwestern United States is a global hotspot for freshwater vulnerability, and snowpack provides much of the region’s freshwater, understanding how climate and forest structure influence snowpack dynamics is increasingly important. In this dissertation I aim to better understand and communicate these dynamics through empirical data collection and the development of a simple vegetation driven temperature-index snow model: SNOW-17(VEG). I then implement the model at a watershed scale using remotely sensed imagery to create vegetation zones and climate simulations to …

Reading The Martian Surface: Impact Crater Distributions And Geochemical Signatures In Gale Crater As Recorded By The Curiosity Rover, Megan E. Hoffman

Earth and Planetary Sciences ETDs

The Curiosity rover has been exploring Gale crater, a large impact basin near the Mars equator since 2012. This mission has greatly improved our ability to explore the surface of Mars with a suite of geologic tools and cameras and has revealed that Mars likely once resembled present-day Earth. In this dissertation, I utilize measurements and data taken by Curiosity to analyze the distribution and preservation of small impact craters at meter scales, I quantify the formation characteristics of a small impact crater cluster, and I examine the presence of barium in a geologic unit with high-Si to constrain sediment …

Directed Searches For Gravitational Waves From Ultralight Vector Boson Clouds Around Merger Remnant And Galactic Black Holes During The First Part Of The Fourth Ligo-Virgo-Kagra Observing Run, A. G. Abac, I. Abouelfettouh, Teviet Creighton, Mario C. Diaz, Raul Alberto Espinosa Perez, J. Lawrence, Francisco Llamas Villarreal, Soma Mukherjee, Volker Quetschke, Miriam Ramos Arevalo, Wenhui Wang

Physics & Astronomy Faculty Publications

We present the first directed searches for long-transient and continuous gravitational waves from ultralight vector boson clouds around known black holes (BHs). We use LIGO data from the first part of the fourth LIGO-Virgo-KAGRA observing run. The searches target two distinct types of BHs and use two new semicoherent methods: hidden Markov model (HMM) tracking for the remnant BHs of the mergers GW230814_230901 and GW231123_135430 (referred to as GW230814 and GW231123 in this study) and a dedicated method using the Band Sampled Data (BSD) framework for the galactic BH in the Cygnus X-1 binary system. Without finding evidence of a …

Surveyception: An Exploration Of Deceptive Survey Forms, Muhammad Danish

Computer Science ETDs

Survey platforms such as Google Forms and Microsoft Forms are widely used for feedback, data collection, and engagement, but scammers increasingly exploit them to distribute phishing and deceptive attacks. This thesis presents a large-scale study of survey-form abuse across ten major providers. We collected 140,000 forms from three sources: public posts on X, search-engine results, and web pages from the top 10 million DomCop-ranked domains. Using automated filtering and manual qualitative review, we identified 2,645 forms requesting sensitive information and classified 566 as scams. These forms used techniques including phishing, private-secret theft, account and personal-data harvesting, financial deception, and psychological …

Mapping Along-Strike Changes In Shallow Subduction Zone Geometry At The Alaska Subduction Zone Using Seismic Reflection And Tectono-Geomorphic Analysis, Madelyn K. Hurd

Earth and Planetary Sciences ETDs

The Alaska subduction zone, where the oceanic Pacific plate subducts beneath the continental North American plate at a rate of 60-66 mm/yr, has hosted more >M8 earthquakes over the last century than any other subduction zone globally. The largest of these, the 1964 M9.2 Alaska earthquake, ruptured 800 km of the margin, including a high slip patch near the trench offshore Kodiak Island. The 1964 rupture area may have overlapped with the 1938 M8.3 Semidi earthquake rupture zone that lies to the west. Slip propagation near the subduction trench during large earthquakes can control tsunamigenesis, and differences in wedge geometry …

Ai-Powered Resume Screening, Sang Suh, Numery Zaber

Faculty Publications

Traditional resume screening is manual, slow, and susceptible to bias, and it struggles to keep pace with today’s application volumes. This paper presents a dual-engine, AI-powered resume screening system designed for transparency and reproducibility. The primary (classical) pipeline encodes resumes and job descriptions using Sentence-BERT (SBERT), computes a resume–job match score via cosine similarity, classifies candidates into 25 job categories using XGBoost, and provides model interpretability through SHAP. In parallel, a prompted large language model (LLM) baseline (GPT-4o/4o-mini) outputs a match score and predicted category for comparative analysis. A Streamlit-based interface integrates both engines to support recruiter workflows and human-in-the-loop …

Timelines Over Tokens: Summarization, Prompting, And Explainable Fine-Tuning For User-Level Suicide Risk Detection, Aditya Tekale

Master's Theses

This research presents a two-stage pipeline for user-level suicide risk detection from Reddit: first, inference-only prompting with summarization; second, fine-tuned encoder classification with explainability and expert validation. The data are user-level: each of the 500 C-SSRS Reddit items is one user’s chronologically concatenated posts and comments (a user timeline), annotated by psychiatrists. Stage one: six prompting strategies zero-shot, few-shot, chain-of-thought, tree-of-thought, least-to-most, and self-consistency are evaluated across six LLMs on multi-class and binary formulations; simple zero-shot achieves the highest balanced accuracy (0.53 multi-class). Error analysis shows longer inputs associate with misclassification (p = 0.002); domain-specific summarization (timelines >2,000 tokens) reduces …

A New Likely Pulsar Binary In 47 Tucanae From Continuum Searches, Thomas Maccarone, Alessandro Paduano, Arash Bahramian, Liliana E. Rivera Sandoval, Jay Strader, James C. A. Miller-Jones, Angiraben D. Mahida, Craig O. Heinke, Laura Chomiuk

Physics & Astronomy Faculty Publications

We present evidence that the X-ray source 47 Tuc W41, long considered to be an X-ray source powered by coronal activity, is actually a redback pulsar binary. The source continually shows LX = 3 × 10³¹ erg s⁻¹ (0.5–10 keV), which is well in excess of the coronal saturation limit for active binaries in quiescence, but is consistent with the intrabinary shock observed in redback pulsars, as is its photon index of Γ = 1.4 ± 0.1. In addition, using deep data from the Australia Telescope Compact Array, we show that W41 is a faint (9.8 ± 1.4μJy …

Elucidation Of Spin-Hamiltonian Parameters Via Spectroscopy, Magnetization, And Computation, Joshua C. Mengell

Chemistry and Chemical Biology ETDs

Molecular Quantum Information Science (QIS) is fundamentally concerned with using spin-systems as quantum bits (qubits) or as sensors. Prerequisite to using molecular systems for QIS applications, it must be understood how one can design molecules with bespoke magnetic characteristics. Herein we study various paramagnetic molecular compounds, describing their complex magnetic characteristics using a spin-Hamiltonian formalism. We utilize various (sometimes novel) methods for determining these spin-Hamiltonian parameters. Many of these molecules possess magnetic characteristics, which make them attractive as qubits or for sensing applications. These characteristics include higher total spin-states (qudits—S_T>1/2), forbidden interstate electronic transitions, systems of spatially distant …

Mapping And Modeling Threat-Evoked Brain States After Early Life Adversity, Taylor W. Uselman

Biomedical Sciences ETDs

Early life adversity (ELA) increases lifelong neuropsychiatric vulnerability. Yet how ELA reorganizes brain-wide activity and circuit coordination across later experience remains unclear. This dissertation tests the hypothesis that ELA alters adult brain-wide activity and responses to threat through disrupted coordination among neural systems that regulate emotional experience, including prefrontal-limbic and monoaminergic systems. Longitudinal manganese-enhanced MRI of adult mice exposed to standard or fragmented early care, combined with computational processing and statistical modeling, quantified brain states before, during, and long after innate predator threat. These studies established that acute threat evokes large-scale, distributed brain activity that evolves over time. ELA potentiates …

Directed Searches For Gravitational Waves From Ultralight Vector Boson Clouds Around Merger Remnant And Galactic Black Holes During The First Part Of The Fourth Ligo-Virgo-Kagra Observing Run, The Ligo Scientific Collaboration, The Virgo Collaboration, The Kagra Collaboration, Marc Favata, Shoan Ghosh, Rodica M. Martin

Department of Physics and Astronomy Faculty Scholarship and Creative Works

We present the first directed searches for long-transient and continuous gravitational waves from ultralight vector boson clouds around known black holes (BHs). We use LIGO data from the first part of the fourth LIGO-Virgo-KAGRA observing run. The searches target two distinct types of BHs and use two new semicoherent methods: hidden Markov model (HMM) tracking for the remnant BHs of the mergers GW230814_230901 and GW231123_135430 (referred to as GW230814 and GW231123 in this study) and a dedicated method using the Band Sampled Data (BSD) framework for the galactic BH in the Cygnus X-1 binary system. Without finding evidence of a …

Final 2022 Unreclaimed Sites Sampling: Ur-07 Site Evaluation Summary Report, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Butte Priority Soils Operable Unit Final 2022 Unreclaimed Sites Sampling: Ur-27 Site Evaluation Summary Report, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Dynamic Reconstruction Engineering Of Anti-Corrosion Ni-Based Anodes For Alkaline Seawater Electrolysis, Yi-Gang Zhang, Wen-Wen Xu, Tian-Yu Zhang, Zhi-Yi Lu

Journal of Electrochemistry

Green hydrogen production via alkaline seawater electrolysis offers an environmentally sustainable and potentially cost-effective route to address both energy and climate challenges. Achieving long-term anode stability under complex ionic environments and industrial current densities remains a central bottleneck. Specifically, Ni-based anodes exhibit intense surface reconstruction during the oxygen evolution reaction, necessitating dynamic anti-corrosion strategies. This mini review systematically summarizes reconstruction engineering approaches to develop anti-corrosion Ni-based anodes of alkaline seawater electrolysis across increasingly complex ionic environments from simulated seawater to real seawater: (i) Cl^– dominated; (ii) Cl^– with co-existing oxyanions, and (iii) Cl^–  with co-existing Br^{– …}

Preparation And Performance Study Of In-Situ Self-Assembled Biphasic Smmn2O5-Nimn2O4 Composite Cathode, Neng-Chu Xia, Yu Zhou, Qin Wang, Jia-You Zhang, Chun Yu, Yang Zhang, Wan-Bing Guan, Jian-Xin Wang

Journal of Electrochemistry

Mullite-structured oxides exhibit excellent oxygen reduction reaction activity, possess a low thermal expansion coefficient due to their unique crystal structure, and can eliminate the need for a barrier layer and simplify the preparation process as they contain no alkaline earth elements. Thus, they hold great promise as novel cathode materials for solid oxide fuel cells. In this work, a mullite-spinel-structured SmMn₂O₅-NiMn₂O₄ (SMO-NMO) composite cathode was one-step synthesized via a solid-liquid composite route, and its in-situ self-assembly enabled good compatibility with the electrolyte without any barrier layer. Characterization results showed that the SMO:NMO = …

In Situ Stm Visualization Of Molecular Structural Evolution During Electrochemical Oxidation Coupling Of Para-Aminothiophenol On Au(111), Zi-Wei Ma, Tai-Rui Wu, An-Ni Zheng, Lai-Ke Chen, Yuan-Hui Xiao, Zhao-Bin Chen, Qing-Na Zheng, Jian-Zhang Zhou, Jia-Wei Yan, De-Yin Wu

Journal of Electrochemistry

Para-aminothiophenol (PATP) is not only a widely-used probe molecule in the field of surface-enhanced Raman spectroscopy (SERS), but also an important model molecule for interfacial reactions, exhibiting distinct photo- and electro-oxidation pathways, so that PATP is selectively activated under different external fields. The evolution of products and intermediates during electrochemical oxidative coupling remains unknown. In this study, we have investigated the dynamic electrochemical oxidation process of PATP on the Au(111) surface using cyclic voltammetry, electrochemical (EC)-SERS, and in situ electrochemical scanning tunneling microscopy (EC-STM). The results showed that PATP forms an unsaturated adsorption coverage on Au(111) in an acidic solution. …

Multiscale Network Modeling Of Native And Modified Photosynthetic Light-Harvesting Complexes, Zane E. Armijo

Chemical and Biological Engineering ETDs

Photosynthetic light-harvesting complexes harvest solar energy and direct electronic excitations toward reaction centers with exceptional efficiency. This dissertation models the Fenna--Matthews--Olson complex of green sulfur bacteria, coupled to the PscA1 reaction center, as a chromophoric network. Forster resonance energy transfer theory, validated against numerically exact hierarchical equations of motion, was implemented in kinetic Monte Carlo simulations to resolve fine-grained excitation-transport pathways. The predicted charge-transfer efficiency of 77\% agrees with experiment, with the FMO2 monomer and its gateway pigment governing interfacial transfer. Systematic single, multi, and symmetry-preserving site removals, interpreted through Mobius inversion, identify critical pigments and show that cooperative effects …

Exploring The Nature And Role Of Local Cation Ordering In Disordered Rock Salt Cathodes For Li- And Na-Ion Batteries, You Wang

Chemistry and Chemical Biology ETDs

Cation-disordered rock-salt (DRX) cathodes provide a highly tunable platform for next-generation Li- and Na-ion batteries, but their electrochemical behavior is strongly influenced by local structural features hidden in average crystal structures. This dissertation systematically investigates local cation ordering in Li- and Na-based DRX cathodes to understand its effects on Li+/Na+ transport, redox activity, structural evolution, and electrochemical performance. In Li-based systems, Raman spectroscopy and electrochemical analysis reveal that local layered cation ordering in Mn- and Fe-based DRX cathodes is closely correlated with electrochemical behavior. Over-stoichiometric Li-based DRX oxyfluorides further demonstrate that excess Li can regulate local cation ordering, improve Li+ …

Non-Traditional Rare-Earth-Doped Oxide Glass As A Gain Medium, Jared S. Tolliver

Optical Science and Engineering ETDs

There is a need for mid-infrared(MIR) lasers in defense, medical, and environmental monitoring. A large part of this technological development is the study of gain media. One class of materials of special interest is glasses with a low maximum phonon energy. These have the fiberization and broad spectral features of glass, whereas glasses with high maximum phonon energy exhibit higher rates of multi-phonon relaxation and can be opaque in the MIR, both of which are detrimental to laser operation. Recent advances in container-less processing have allowed for the study of new glasses that aren’t possible with conventional fabrication techniques. One …