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Articles 6661 - 6690 of 65331
Full-Text Articles in Entire DC Network
Towards A Global Food Systems Datahub: Editorial, Hande Küçük Mcginty, Cogan Shimizu, Pascal Hitzler, Ajay Sharda
Towards A Global Food Systems Datahub: Editorial, Hande Küçük Mcginty, Cogan Shimizu, Pascal Hitzler, Ajay Sharda
Computer Science and Engineering Faculty Publications
In the quest for agricultural sustainability, we face the challenge of feeding the global population under the constraints of finite resources and a delicate ecological balance. The intricate interplay of climate dynamics, socio-economic factors, and environmental stewardship demands an approach to agriculture that is as intelligent and adaptive as it is respectful of our planet’s capacities. Central to this endeavor is the synthesis and utilization of vast, heterogeneous datasets that span from crop genomics to market trends, and from soil health to consumer preferences. Yet, the current paradigm is fragmented, with valuable data isolated across domains, lacking the coherence and …
Butte Priority Soils Operable Unit (Bpsou) Revised Draft Final Insufficiently Reclaimed Sites Field Sampling Plan (Fsp) Bres No. 181 – Mountain Con-3 Dump And Responses To Agency Comments, Mike Mcanulty
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
Final 2024 Residential Metals Abatement Program (Rmap) Walkerville Park (Alley Of North Main And Alley Of West Daly) Soil Remedial Action Work Plan (Rawp), Pioneer Technical Services, Inc.
Final 2024 Residential Metals Abatement Program (Rmap) Walkerville Park (Alley Of North Main And Alley Of West Daly) Soil Remedial Action Work Plan (Rawp), Pioneer Technical Services, Inc.
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
2024 Gateway Magazine, College Of Computing, Michigan Technological University
2024 Gateway Magazine, College Of Computing, Michigan Technological University
College of Computing Annual Magazines
Table of Contents
- 50 Years of Computer Science at Michigan Tech
- Data Science for a Changing Planet
- Healthcare Transformed
- Mechatronics Matters
- Powered by Michigan Tech Talent
- Esports: Bringing Everything Great about Sports to More People
- The Michigander Scholars Program: Electrifying Careers in Michigan
- College of Computing News
Interpretable Spatio-Temporal Embedding For Brain Structural-Effective Network With Ordinary Differential Equation, Haoteng Tang, Guodong Liu, Siyuan Dai, Kai Ye, Kun Zhao, Wenlu Wang, Carl Yang, Lifang He, Alex D. Leow, Paul Thompson
Interpretable Spatio-Temporal Embedding For Brain Structural-Effective Network With Ordinary Differential Equation, Haoteng Tang, Guodong Liu, Siyuan Dai, Kai Ye, Kun Zhao, Wenlu Wang, Carl Yang, Lifang He, Alex D. Leow, Paul Thompson
Computer Science Faculty Publications
The MRI-derived brain network serves as a pivotal instrument in elucidating both the structural and functional aspects of the brain, encompassing the ramifications of diseases and developmental processes. However, prevailing methodologies, often focusing on synchronous BOLD signals from functional MRI (fMRI), may not capture directional influences among brain regions and rarely tackle temporal functional dynamics. In this study, we first construct the brain-effective network via the dynamic causal model. Subsequently, we introduce an interpretable graph learning framework termed Spatio-Temporal Embedding ODE (STE-ODE). This framework incorporates specifically designed directed node embedding layers, aiming at capturing the dynamic inter-play between structural and …
Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Residential Metals Abatement Program (Rmap) Revised 2024 Walkerville Park (Alley Of North Main & Alley Of West Daly) Soil Remedial Action Work Plan (Rawp) (Dated September 18, 2024), Molly Roby
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
Projected Loss Of Rock Glacier Habitat In The Contiguous Western United States With Warming, Abigail C. Lute, John T. Abatzoglou, Andrew G. Fountain, Timothy C. Bartholomaus
Projected Loss Of Rock Glacier Habitat In The Contiguous Western United States With Warming, Abigail C. Lute, John T. Abatzoglou, Andrew G. Fountain, Timothy C. Bartholomaus
Geology Faculty Publications and Presentations
Rock glaciers support alpine biodiversity and may respond more slowly to warming than snow or glaciers. While responses of snow and glaciers to climate change are relatively well understood, a robust assessment of rock glacier environmental niche, future distributions of rock glaciers and potential for development of rock glaciers from current glaciers is lacking. Using process-relevant, high-resolution environmental descriptors, we develop a species distribution model of the topographic, geologic and hydroclimatic niche of rock glaciers that provides novel estimates of potential rock glacier distributions for different climates. We identify mean annual air temperature and headwall area as the dominant controls …
Advancements In The Programmable Hyperspectral Seawater Scanner Measurement Technology For Enhanced Detection Of Harmful Algal Blooms, John J. Langan, Jungyun Bae
Advancements In The Programmable Hyperspectral Seawater Scanner Measurement Technology For Enhanced Detection Of Harmful Algal Blooms, John J. Langan, Jungyun Bae
Michigan Tech Publications
The Programmable Hyperspectral Seawater Scanner (PHySS) represents a significant breakthrough in monitoring harmful algal blooms (HABs), specifically targeting the “Florida red tide” caused by Karenia brevis. By utilizing a Fourth-Derivative Spectral Similarity Index (SI), this study establishes a strong positive correlation between the SI and phytoplankton counts, underscoring the PHySS’s potential for early detection and effective management of HABs. Our findings suggest that the PHySS could act as a predictive tool, offering crucial lead time to mitigate the ecological and economic repercussions of blooms. However, this study also identifies certain limitations of the PHySS technology, such as its inability to …
Building Community Resilience To Extreme Heat: Lessons Learned From Spokane, Wa Community Conversations, Anna Reed, Brian G. Henning, Marina Cortes Espinosa, Hannah Mckinley, Tania Busch Isaksen
Building Community Resilience To Extreme Heat: Lessons Learned From Spokane, Wa Community Conversations, Anna Reed, Brian G. Henning, Marina Cortes Espinosa, Hannah Mckinley, Tania Busch Isaksen
Climate, Water, and the Environment Research
Heat is the primary cause of weather-related mortality in the United States. The 2021 Northwest Heat Dome highlighted this susceptibility. In Washington State, 159 excess deaths were attributed to the 7-day period of unprecedented extreme heat between June 26th and July 2nd. This impact was felt even in some of the more acclimatized parts of the state, like Spokane County, where 19 heat-related deaths were reported. As climate change increases the frequency, duration, and intensity of extreme heat events, creating and sustaining heat-resilient communities has become an urgent public health priority. On 6 June 2023, Gonzaga University, in partnership with …
Efficient Phosphate Removal From Water Using Ductile Cast Iron Waste: A Response Surface Methodology Approach, Mai Hassan Dr., Nada Alkhashab Eng., Ahmed Osman Dr., Dalia A. Ali Eng
Efficient Phosphate Removal From Water Using Ductile Cast Iron Waste: A Response Surface Methodology Approach, Mai Hassan Dr., Nada Alkhashab Eng., Ahmed Osman Dr., Dalia A. Ali Eng
Chemical Engineering
Water scarcity is a critical issue worldwide. This study explores a novel method for addressing this issue by using ductile cast iron (DCI) solid waste as an adsorbent for phosphate ions, supporting the circular economy in water remediation. The solid waste was characterized using XRD, XRF, FTIR, and particle size distribution. Wastewater samples of different phosphate ion concentrations are prepared, and the solid waste is used as an adsorbent to adsorb phosphate ions using different adsorbent doses and process time. The removal percentage is attained through spectrophotometer analysis and experimental results are optimized to get the optimum conditions using Design …
Instructional Systems Design: The Diffusion And Adoption Of Technology: (Volume 2), Cassandra Celaya (Author), Pamela J. Downing (Author), Jessica Shifflett (Author), Debbie Gdula (Author), Tracie Barr (Author), Miguel Ramlatchan (Author & Editor)
Instructional Systems Design: The Diffusion And Adoption Of Technology: (Volume 2), Cassandra Celaya (Author), Pamela J. Downing (Author), Jessica Shifflett (Author), Debbie Gdula (Author), Tracie Barr (Author), Miguel Ramlatchan (Author & Editor)
University Administration Bookshelf
Instructional designers, instructional systems designers, and other educational technologists are, by their nature, innovators. These professionals apply and extend the applied science of learning, systems, communication, and instructional design theory to help students learn. Technology in some capacity is used to make the connections between subject matter experts, teachers, instructors, and their learners. It is common for instructional designers to seek new tools, techniques, and innovations for the improvement of learning, access, quality, and student satisfaction. However, the adoption and diffusion of new educational technology and innovation is a complex process that depends on many variables. Understanding these processes and …
Santa Clara Magazine, Volume 65 Number 2, Fall 2024 [Print Issue 62:2], Santa Clara University
Santa Clara Magazine, Volume 65 Number 2, Fall 2024 [Print Issue 62:2], Santa Clara University
Santa Clara Magazine
12 - INCREASING ACCESS Discerning one’s dream requires a whole set of experiences based on community, opportunity, and, yes, cash. Leslie Griffy
16 - UNPACKING UTOPIA It seems like billionaire-backed utopias are popping up all over the map. What does it take to build a perfect city? Lauren Loftus
22 - A WEALTH OF WELL-BEING In his new book, Professor Meir Statman explores a holistic approach to financial and life well-being. Leslie Griffy
26 - A WOMAN'S PLACE Despite being denied access to the priesthood, Catholic women find new ways to lead. Leslie Griffy
Water Quality Of The Napo River Basin: A Comparative Study Of Streams In Polycultures And Oil Palm Monocultures, Eva C. Andersen
Water Quality Of The Napo River Basin: A Comparative Study Of Streams In Polycultures And Oil Palm Monocultures, Eva C. Andersen
Ecuador: Comparative Ecology and Conservation
Oil palm cultivation has grown rapidly in recent years in Ecuador, resulting in significant economic and environmental changes to the country. In the Northeast Ecuadorian Amazon, a hotspot for both petroleum extraction and oil palm production, poor water quality has been a persistent issue for decades. However, knowledge gaps exist regarding to what extent intensive monocultures, such as oil palm, contribute to poor water quality in this region, and how they compare to other forms of agriculture. This investigation compared water quality in streams of the Napo River watershed running through oil palm monocultures and traditional polycultures. Water quality was …
The Psychological Impacts Of Algorithmic And Ai-Driven Social Media On Teenagers: A Call To Action, Sunil Arora, Sahil Arora, John Hastings
The Psychological Impacts Of Algorithmic And Ai-Driven Social Media On Teenagers: A Call To Action, Sunil Arora, Sahil Arora, John Hastings
Research & Publications
This study investigates the meta-issues surrounding social media, which, while theoretically designed to enhance social interactions and improve our social lives by facilitating the sharing of personal experiences and life events, often results in adverse psychological impacts. Our investigation reveals a paradoxical outcome: rather than fostering closer relationships and improving social lives, the algorithms and structures that underlie social media platforms inadvertently contribute to a profound psychological impact on individuals, influencing them in unforeseen ways. This phenomenon is particularly pronounced among teenagers, who are disproportionately affected by curated online personas, peer pressure to present a perfect digital image, and the …
2024 Celebration Of Scholarship, Creativity, And Engagement, Todd Bruns, Anna Nelson
2024 Celebration Of Scholarship, Creativity, And Engagement, Todd Bruns, Anna Nelson
Programs
Annually, Eastern Illinois University honors faculty achievements in the areas of research, creativity, and engagement. The list of faculty accomplishments is truly impressive, reflective of an engaged faculty committed to excellence and the ongoing pursuit and creation of knowledge. Many of these accomplishments occurred in collaboration with our students, who serve as co-authors, research assistants and partners in bringing these activities to fruition. In some cases, these professional ambitions transpired over many years and are a testament to persistence and tenacity. We extend a sincere message of congratulations for this diverse range of achievements, which bring distinction to our departments, …
Clark Tailings Consolidated Waste Management Area (Ctcwma) Site Investigation Draft Data Summary Report 2019 Surface Water, Groundwater Seep, And Soil Characterization 2021-2023 Surface Water And Groundwater Seep Evaluation 2023 Waterloo Aps Soil And Groundwater Evaluation, Woodard & Curran
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
A Community-Level Investigation Of Heavy Metal Pollution In Street Sediments From Terre Haute, Indiana, Kyra Copp '25, Kenneth Brown, Nora Bedwell '26, Camden Brown '25
A Community-Level Investigation Of Heavy Metal Pollution In Street Sediments From Terre Haute, Indiana, Kyra Copp '25, Kenneth Brown, Nora Bedwell '26, Camden Brown '25
Annual Student Research Poster Session
Urban environments contain environmental legacy issues that can have long-term negative public health consequences. Investigating these legacy issues can help constrain potential sources and their impact on communities. This study focuses on street sediment found in Terre Haute, Indiana, a city with an extensive history of coal-fired power production, high-traffic volumes, steel manufacturing, and Pb-based paint usage. This research specifically focuses on Terre Haute’s Sheridan Park community. Six bulk street sediment samples were analyzed by pXRF at DePauw University. This analysis revealed elevated concentrations of Pb (22-152 ppm), As (8-15 ppm), Cu (35-237 ppm), and Zn (149-634 ppm) in all …
Understanding And Enhancing Sustainability Literacy In Cal Poly's College Of Engineering, Kenna Toohill
Understanding And Enhancing Sustainability Literacy In Cal Poly's College Of Engineering, Kenna Toohill
College of Engineering Summer Undergraduate Research Program
This study uses survey data collected from Cal Poly students to analyze engineering students' sustainability knowledge and their perspectives on Cal Poly's efficacy in teaching concepts in sustainability. It also compares the College of Engineering to other colleges to determine if, and how, CENG is behind in environmental education at Cal Poly.
Integrated Treatment Of Black Wastewater Using Sedimentation, Constructed Wetland, And Nanoparticles Coagulation, Hussein I. Abdel-Shafy, Mona Mansour, Mohamed A. El-Khateeb, Yang Deng
Integrated Treatment Of Black Wastewater Using Sedimentation, Constructed Wetland, And Nanoparticles Coagulation, Hussein I. Abdel-Shafy, Mona Mansour, Mohamed A. El-Khateeb, Yang Deng
Department of Earth and Environmental Studies Faculty Scholarship and Creative Works
The aim of the present investigation was to achieve an efficient treatment for black wastewater for non-restricted reuse. The treatment included sedimentation followed by horizontal flow constructed wetland (HF-CW), and finally chemical coagulation using magnetite (Fe3O4) nanoparticles. For the wetland, the average organic loading rate (OLR) was 42.83 biochemical oxygen demand (BOD)/m2 day and 71.30 g chemical oxygen demand (COD)/m2 day, while average surface loading rate was 0.185 m3/m2 day. The obtained results revealed that removal percentage of COD, BOD, and total suspended solids (TSS) by sedimentation followed by processing through wetlands was 80.3, 81.6, and 80%, which corresponds to …
Comprehensive Lead Exposure Vulnerability For New Jersey: Insights From A Multi-Criteria Risk Assessment And Community Impact Analysis Framework, Gift Fabolude, Charles Knoble, Anvy Vu, Danlin Yu
Comprehensive Lead Exposure Vulnerability For New Jersey: Insights From A Multi-Criteria Risk Assessment And Community Impact Analysis Framework, Gift Fabolude, Charles Knoble, Anvy Vu, Danlin Yu
Department of Earth and Environmental Studies Faculty Scholarship and Creative Works
Lead contamination remains a persistent and insidious threat, particularly affecting young children and vulnerable communities. This study aims to develop a comprehensive sources-based lead exposure index map for New Jersey municipalities by integrating diverse lead contamination data, including lead-based paint, lead service lines, proximity to superfund and brownfield sites, road density, and gas stations, analyzing how municipality socioeconomic and land use factors impact lead exposure. The research employs Principal Component Analysis (PCA) and Analytical Hierarchy Process (AHP) to create two distinct multi-criteria lead exposure indices. The indices are mapped to understand the spatial distribution and magnitude of lead exposure risks …
Subterranean Medicinal Bottles Are Treasures That Reveal The Growth Of Lincoln's Early Drug Stores, Mark Griep, June Weber, Erik Schulz, Effie Athanassopoulos
Subterranean Medicinal Bottles Are Treasures That Reveal The Growth Of Lincoln's Early Drug Stores, Mark Griep, June Weber, Erik Schulz, Effie Athanassopoulos
Department of Anthropology: Faculty Publications
Archeologists unearthed medicine bottles embossed with the names of nine early Lincoln (Nebraska) drug stores, giving insight into the rapid growth of pharmacies and health care from the 1880s up to the Pure Food and Drug Act of 1906.
Investigating Public Acceptance Of Responses To Public Emergencies: Based On Text Transparency And Empathy Sentiment Analysis, Xuefeng Zhang, Yelin Huang
Investigating Public Acceptance Of Responses To Public Emergencies: Based On Text Transparency And Empathy Sentiment Analysis, Xuefeng Zhang, Yelin Huang
Journal of Scientific Information Research
[Purpose/significance]Regarding the responses to public emergencies published by official agencies on social media, this study aims to measure information transparency and empathy in the response text, and further to investigate their influence on public acceptance of responses. [Method/process]This study used public emergency responses published on Sina Weibo, a Chinese popular social media, as data source. Through carefully collecting and filtering, we finally acquired 170 public emergency responses released from 2021 to 2023. Furthermore, by using methods of content analysis, manual coding, and natural language processing, we measured information transparency of responses from three aspects: information disclosure, information accuracy, and information …
Construction And Application Of Multi-Dimensional Portrait System For Green Technology Innovation Enterprises In China: Taking The Green Transportation Technology Field As An Example, Wenke Hao, Jianlin Yang, Lei Miao
Construction And Application Of Multi-Dimensional Portrait System For Green Technology Innovation Enterprises In China: Taking The Green Transportation Technology Field As An Example, Wenke Hao, Jianlin Yang, Lei Miao
Journal of Scientific Information Research
[Purpose/significance]By constructing and applying the multi-dimensional portrait system of green technology innovation enterprises in China, this paper aims to comprehensively understand the status quo, advantages and obstacles of enterprises in specific fields in green technology innovation, so as to provide scientific references and suggestions for relevant government departments and decision makers of enterprises. [Method/process]Based on resource based view and environmental dependence theory, we select the internal and external labels of enterprises, and designs a multi-dimensional label system to objectively describe the performance of enterprises in terms of profitability,scientific research and innovation, public opinion and environmental responsibility. Then, the green technology …
A Guideline For Open-Source Tools To Make Medical Imaging Data Ready For Artificial Intelligence Applications: A Society Of Imaging Informatics In Medicine (Siim) Survey, Sanaz Vahdati, Bardia Khosravi, Elham Mahmoudi, Kuan Zhang, Pouria Rouzrokh, Shahriar Faghani, Mana Moassefi, Aylin Tahmasebi, Katherine Andriole, Peter Chang, Keyvan Farahani, Mona Flores, Les Folio, Sina Houshmand, Maryellen Giger, Judy Gichoya, Bradley Erickson
A Guideline For Open-Source Tools To Make Medical Imaging Data Ready For Artificial Intelligence Applications: A Society Of Imaging Informatics In Medicine (Siim) Survey, Sanaz Vahdati, Bardia Khosravi, Elham Mahmoudi, Kuan Zhang, Pouria Rouzrokh, Shahriar Faghani, Mana Moassefi, Aylin Tahmasebi, Katherine Andriole, Peter Chang, Keyvan Farahani, Mona Flores, Les Folio, Sina Houshmand, Maryellen Giger, Judy Gichoya, Bradley Erickson
Department of Radiology Faculty Papers
In recent years, the role of Artificial Intelligence (AI) in medical imaging has become increasingly prominent, with the majority of AI applications approved by the FDA being in imaging and radiology in 2023. The surge in AI model development to tackle clinical challenges underscores the necessity for preparing high-quality medical imaging data. Proper data preparation is crucial as it fosters the creation of standardized and reproducible AI models while minimizing biases. Data curation transforms raw data into a valuable, organized, and dependable resource and is a fundamental process to the success of machine learning and analytical projects. Considering the plethora …
Regulating Shipping Of Carbon Dioxide For Sequestration, Carolina Arlota, Michael B. Gerrard
Regulating Shipping Of Carbon Dioxide For Sequestration, Carolina Arlota, Michael B. Gerrard
Faculty Scholarship
A number of facilities intended for permanent sequestration of carbon dioxide are being developed in the United States. Several will be located on or near the coast of the Gulf of Mexico, making them easily accessible to ships. Meanwhile, in Europe there is substantial interest in capturing carbon dioxide from industrial operations, but currently inadequate sequestration facilities, and growing interest in shipping carbon dioxide for sequestration in the United States. This Article reviews the main U.S. federal laws applicable to transportation and geologic storage of carbon dioxide, including laws enacted to implement relevant international treaties. The Article also contextualizes its …
Mathematics In Contemporary Society, Patrick J. Wallach
Mathematics In Contemporary Society, Patrick J. Wallach
Open Educational Resources
Mathematics in Contemporary Society is the textbook that corresponds to MA-321, the course of the same name. The course is designed to provide students with mathematical ideas and methods found in the social sciences, the arts, and in business. Topics will include fundamentals of statistics, scatterplots, graphics in the media, problem solving strategies, dimensional analysis, mathematics in music and art, and mathematical modeling. EXCEL is used to explore real world applications.
Bridging The Birth Divide: Doula Perspectives On Cesarean Trends In Switzerland And The U.S., Lina Verghese
Bridging The Birth Divide: Doula Perspectives On Cesarean Trends In Switzerland And The U.S., Lina Verghese
Switzerland: Global Health and Development Policy
Cesarean section (C-section) rates remain a global concern, reflecting variations in maternal care practices, healthcare access, and systemic biases. While essential in certain cases, the overuse of C-sections is linked to adverse maternal and neonatal outcomes, reinforcing medicalized approaches to childbirth. This study explores disparities in C-section rates across regions in Switzerland (Zug and Jura) and the United States (Mississippi and Alaska) and examines the role of doulas in addressing these disparities.
Using a mixed-methods approach, qualitative interviews with doulas and quantitative regional data highlight systemic and cultural influences on C-section trends. In affluent Zug, convenience and elective procedures drive …
Burden Of Disease Attributable To High Body Mass Index: An Analysis Of Data From The Global Burden Of Disease Study 2021, Xiao-Dong Zhou, Qin-Fen Chen, Wah Yang, Mauricio Zuluaga, Giovanni Targher, Christopher Byrne, Luca Valentu, Fei Luo, Christos Katsouras, Christopher Opio
Burden Of Disease Attributable To High Body Mass Index: An Analysis Of Data From The Global Burden Of Disease Study 2021, Xiao-Dong Zhou, Qin-Fen Chen, Wah Yang, Mauricio Zuluaga, Giovanni Targher, Christopher Byrne, Luca Valentu, Fei Luo, Christos Katsouras, Christopher Opio
Internal Medicine, East Africa
Background: Obesity represents a major global health challenge with important clinical implications. Despite its recognized importance, the global disease burden attributable to high body mass index (BMI) remains less well understood.
Methods: We systematically analyzed global deaths and disability-adjusted life years (DALYs) attributable to high BMI using the methodology and analytical approaches of the Global Burden of Disease Study (GBD) 2021. High BMI was defined as a BMI over 25 kg/m2 for individuals aged ≥20 years. The Socio-Demographic Index (SDI) was used as a composite measure to assess the level of socio-economic development across different regions. Subgroup analyses considered age, …
Water Current, Volume 56, No. 3, Fall 2024
Water Current, Volume 56, No. 3, Fall 2024
Water Current Newsletter
No abstract provided.
Enzyme Encapsulation Within The Hk97 Virus-Like Particle: An Investigation Of Substrate Inhibition Kinetics Within A Confined And Crowded Environment, Joseph B. Lively
Enzyme Encapsulation Within The Hk97 Virus-Like Particle: An Investigation Of Substrate Inhibition Kinetics Within A Confined And Crowded Environment, Joseph B. Lively
Chemistry Theses
Substrate inhibition is a paradoxical phenomenon observed in enzyme kinetics where increasing substrate concentrations lead to a marked decrease in the rates of enzyme-catalyzed reactions. Affecting an estimated 20% of studied enzymes, substrate inhibition poses significant challenges to the understanding of their function in essential biological processes and to their exploitation in industrial and therapeutic contexts. Studies show substrate inhibition to be a real limitation in vitro and rational conclusions have been drawn to explain the relevance of substrate inhibition in the self-regulation of biological pathways. However, there is currently no consensus on what role substrate inhibition plays in vivo …