Digital Commons Network^™

Synthesis And In Vitro Evaluation Of Potential Tuberculosis Antibiotics, Chloe Spradlin

Honors Projects

Tuberculosis (TB) remains a major global health threat. The bacteria causing TB, Mycobacterium tuberculosis, has proven difficult to combat, as drug resistance (MDR-TB) continues to develop within the bacteria. Access to healthcare in developing countries complicates the treatment of TB and MDR-TB. The World Health Organization has declared TB a global health crisis and has called for the development of new therapies. Previously, we used AutoDock Vina software to design novel drugs targeting InhA, an enzyme involved in mycobacterial cell wall synthesis. This project focuses on synthesizing amino diphenyl amides (ADA) and screening them against Mycobacterium. The synthetic pathway enables …

Quantifying Nutrient Fluxes Across The Sediment-Water Interface In The Lafayette River Estuary, Adriana E. Amrhein

OES Theses and Dissertations

The Lafayette River, a shallow, eutrophic tributary of the Chesapeake Bay, experiences seasonal harmful algal blooms (HABs). While management efforts focus on reducing external nutrient inputs, internal loading from benthic sediments remains poorly constrained. This study quantifies spatial and seasonal variability in nutrient and radium isotope fluxes across the sediment–water interface at three sites where HABs are known to initiate and represent contrasting sediment textures and hydrodynamic conditions. Sediment cores and porewater samples were collected in summer 2023 and winter 2024 to measure grain size, porosity, dissolved nutrients (NH₄⁺, NOₓ⁻, PO₄³⁻), and radionuclide activities (²²⁴Ra and ²²⁸Th). Radium isotope disequilibrium …

Dissecting The Etiology Of Alcohol Use Disorder By An Integrative Heritable Component Approach, Ivy Garrenton

Computer Science Theses & Dissertations

Alcohol Use Disorder (AUD) is a pervasive condition characterized by complex interplay among genetic, phenotypic, and environmental factors. Although previous studies have identi fied genetic loci associated with alcohol consumption, these efforts have not captured the genetic heterogeneity and gene-environment interactions underlying AUD pathogenesis. To address this critical gap, we developed a novel statistical methodology that integrates phenotypic, genotypic, and environmental data through an environmentally modified Genetic Relationship Matrix (GRM) to derive AUD-related traits with enhanced heritability.

This approach demonstrated superior performance in both simulated and real-world datasets. Traits derived using the environmentally modified GRM exhibited significantly higher estimated heritability …

Wright State University's Celebration Of Student Research, Scholarship & Creative Activities From Wednesday, April 1, 2026, Wright State University

Celebration of Undergraduate & Graduate Research, Scholarship, and Creative Activities Materials

The student abstract booklet is a compilation of abstracts from students' oral and poster presentations at Wright State University's Celebration of Student Research, Scholarship & Creative Activities on April 1, 2026.

Folic Acid–Carbon Dot–Gemcitabine Nanoparticles For Targeted Cancer Drug Delivery, Irfan Huda, Hua Mei

SPARK Symposium Presentations

This project aims to develop a folic acid-attached carbon dot nanoparticle system (FA-CDs-GEM) for the targeted delivery of gemcitabine to cancer cells. While gemcitabine is widely used, its effectiveness is limited because a short in vivo half life and lack of selectivity, which lead to severe side effects. Carbon dots offer a simple and modifiable platform as the drug delivery and bioimaging agent. Conjugation of folic acid to the carbon dots enables selective targeting of cancer cells that overexpress folate receptors. In this study, we synthesized and characterized FA-CD-GEM nanoparticles and developed an HPLC calibration curve of GEM to accurately …

Enhancing Urban Garden Capacity By Linking Biodiversity And Ecosystem Function, Mary T. Nguyen, Carleen Rauh, Shelby Gresch, Charlotte Correiro, Heidi Elmendorf, Adriane Fugh-Berman, Gina Wimp, Alexandra L. Decandia

Virginia Journal of Science

Urban agriculture broadly describes food and plant cultivation in metropolitan areas. While biodiversity is thought to support ecosystem health and resilience, the relationship between above-ground and below-ground diversity has been understudied in urban green spaces. This study examines plant, animal, bacterial, and fungal diversity across three distinct urban habitats: a turf lawn, a forb garden, and a farming space. Using bacterial 16S rRNA and fungal ITS2 sequencing, soil nutrient analyses, and surveys of vegetation and wildlife, we connect diverse philosophies in urban agriculture to their role in advancing community diversity and ecosystem function. We found that different urban gardens support …

Columnas: The Honors Program Newsletter At Bentley University, Amanda Li, Wilson Jan, Michael Raphael, Alexandra Rieckehoff, Karina Wu, Michael Shehata, Nilufar Noorian, Eloise Weintraub

Honors Program

INSIDE THE MODERN WORLD

Page 2: Stepping Out by Amanda Li

Page 3: Inside the Corporate Slop Bowl by Wilson Jan

Page 4: The Silencing: An Evaluation of the Global Attacks on the Right to Protest by Michael Raphael

THE SOUND OF CHANGE

Page 5: The Social, Cultural, and Economic Impact of Bad Bunny by Alexandra Rieckehoff

Page 6: Streaming Changed Music, But Is It Fair to Artists? by Karina Wu

Page 7: Feeling the Music: How Haptic Wearables Are Changing the Way We Experience Sound by Michael Shehata

SHIFTING SYSTEMS

Page 8: The Story Behind Davos, One of the …

Imidacloprid Effects On The Survival And Cutaneous Microbiome Of Northern Leopard Frogs, Evelyn Margaret Osterloo

Honors Thesis

Amphibians are experiencing population declines due to habitat loss, climate change, and diseases, particularly chytridiomycosis caused by the fungus Batrachochytrium dendrobatidis. Protection from this fungal infection stems from the cutaneous microbiome. Pesticides have been shown to affect amphibians in a variety of ways, including reducing survival, locomotor performance, and accumulation in body tissues. Pesticides may also lead to changes in the cutaneous microbiome affecting amphibians who rely on these organisms as an anti-Bd defense mechanism. To investigate the effect of imidacloprid, a neonicotinoid insecticide, Northern Leopard frogs (Lithobates pipiens) were subjected to sublethal concentrations (control = …

Numerical Study Of Nutrient Mixing In Trabecular Bone In Microgravity, Disuse And Normogravity, Sagar Gharti

Doctoral Dissertations and Master's Theses

Mechanical loading is known to regulate bone remodeling by driving interstitial fluid flow which stimulates cells and drives nutrient transport within the trabecular network. In microgravity, the absence of mechanical stimulation or loading suppresses convective flow processes, causing diffusion-driven nutrient mixing and renewal, and accelerated bone loss. This thesis investigates how oscillation frequency and trabecular bone density jointly control nutrient mixing and wall shear stress within trabecular cavities.

A computational fluid dynamics (CFD) framework is developed in STAR-CCM+ using a soft-cap oscillation model that mimics cyclic compression. Three idealized trabecular morphologies are simulated across different frequencies to represent microgravity or …

Developing A Multi-Band Gnss Remote Sensing Station To Measure Precipitable Water Vapor For Flash Flood Nowcasting, Madison Gleydura

Doctoral Dissertations and Master's Theses

Flash flood nowcasting in Central and Southern Appalachia is particularly challenging due to steep terrain, narrow valleys, highly localized rainfall patterns, and limited measurement coverage. Traditional remote sensing methods, such as Doppler radar and microwave radiometry, suffer from reduced resolution at long range and signal blockage by mountains. GNSS-meteorology offers an established alternative for measuring precipitable water vapor and is currently integrated into several numerical weather models. Recent research demonstrates that commercial-grade GNSS receivers can produce tropospheric products comparable to those from geodetic-grade equipment. The gaps in mountain coverage can be addressed by developing a low-cost, self-contained embedded system that …

Conservation Communication In Web 2.0: A Mixed Methods Analysis Of Alveus Sanctuary's Strategies On Twitch.Tv, Hope Denison

Senior Theses

This thesis examines how environmental creators can effectively transmit conservation messages in the evolving Web 2.0 media environment. The case of Alveus Sanctuary, a virtual sanctuary and education center on Twitch.TV, is used to explore the strategies currently used to engage audiences and raise ecological awareness online. Thematic analysis of interviews with the sanctuary’s founder revealed that Alveus combines traditional environmental education with an influencer business model to engage online audiences, leveraging parasocial behavior, interactivity, and collaboration to garner support. A quantitative content analysis of social media posts revealed that these strategies effectively induce parasocial engagement in online spaces. These …

Increased Backbone Rigidity Of Artificial Transcription Factors, Jasmine Glover, Emma Otey, Joanna K. Kwao, Nicholas Truex

Senior Theses

Programming DNA-binding proteins is an effective strategy for developing therapeutics that regulate gene expression. These proteins can directly bind to DNA to activate or repress transcription of specific genes. Zinc finger proteins are a class of DNA-binding proteins commonly found in eukaryotic organisms. Their DNA-binding function is derived from unique amino acid sequences within each domain that recognizes specific nucleotides, allowing each finger to selectively recognize three DNA base pairs. Adjoining of multiple domains in tandem allows recognition of a specific DNA sequence. Artificial transcription factors can be made of multiple zinc finger domains arranged in tandem and engineered to …

Rethinking News Classification Through A Multi-Dimensional Framework, Luana De Jesus Ferreira

Honors Theses

This thesis proposes a multi-dimensional framework for news classification that evaluates articles across three independent dimensions: headline accuracy, language neutrality, and content reliability. These dimensions produce both a continuous reliability score and a five-tier interpretive scale, while additionally classifying articles by genre and topic. To operationalize this framework, a structured annotation protocol was developed and applied to a dataset of 373 news articles drawn from 79 outlets spanning a wide range of contemporary media ecosystem. A binary Logistic Regression classifier trained on the ISOT Fake News Dataset was then evaluated against this dataset to examine how a model trained on …

Radiation Protection Factor Research: The Keystone For Conventional-Nuclear Integration (Cni), Andrew W. Decker

Faculty Publications

This article briefly describes Defense Threat Reduction Agency (DTRA) vehicle Radiation Protection Factor (RPF) research and explains its critical role in enabling future Operations in a Nuclear Environment (ONE) and Conventional-Nuclear Integration (CNI) on behalf of the US Department of War (DoW).1 As such, the background and practical utility of RPF values is discussed, as well as the justification for renewed Army and DoW investment into RPF research to enhance Joint military planning, survivability, and lethality on tomorrow’s nuclear battlefields. Advances in DTRA RPF research directly strengthen US strategic and extended deterrence efforts and support all Agencies and Departments responsible …

Do Purpleair Monitors Democratize Data For The Environment?, Christopher Rick, Kyla Lorden

Student Publications

PurpleAir monitors may serve a vital role in marginalized or under-monitored communities nationwide. These low-cost monitors—roughly $300—give communities the ability to monitor their air quality at local geographies in ways that are infeasible for expensive, regulatory-grade air monitors. They also have the potential to aid community advocacy efforts around environmental and transportation policy by giving community members literal ownership over the monitoring, including precise locations, and philosophical ownership over the advocacy efforts. To determine the potential democratization of air quality data by PurpleAir monitors in socially disadvantaged communities, we analyze the sociodemographic characteristics of neighborhoods with PurpleAir monitors. We find …

The Importance Of Body Size And Spatial Scale In Modeling Winter Bird Distributions, Carissa M. Mobley

Student Publications

Birds’ annual cycles include biologically linked breeding and non-breeding seasons, yet most research and bird atlases focus exclusively on the breeding season. There have been very few winter bird atlas projects in North America, and none have been published for the northeastern United States. Short daylight hours and harsh weather limit winter survey coverage, making species distribution models (SDMs) essential for addressing spatial gaps.

I evaluated the optimal spatial scale for SDMs across bird species differing in body size and tested whether optimal scale varies with body mass. Using 16,967 eBird checklists collected during the first winter survey period (December …

Polylactic Acid (Pla) Microplastic Toxicity In C. Elegans, Maria Gamez, Dana Farley, Chiara Maldonado, David Mares

Posters - 2026

• Microplastics (MPs, > 5 mm1) are an environmental pollutant that pose health risks to humans. • Primary MPs are created for direct use or plastic stocks, and secondary MPs are created when plastics in the environment break down over time. • Microplastic exposure can cause oxidative stress, metabolic disorders, immune responses, neurotoxicity, and reproductive issues2-3. • Polylactic Acid (PLA) is a biodegradable plastic used in everyday items, such as food packaging, and as a polymer in 3D printing. • PLA exposure to fish causes organ damage5 and C. elegans exposure to primary PLA MPs and UV-aged MPs reduced reproduction6-7 . …

Saved From The Brink Of Collapse: Evaluating The Success Of The Sussex Kelp Recovery Project, Keagan Farrell, Kelly Swyers, Adan Vasquez

Posters - 2026

Kelp forests are vital to ocean health, they provide habitat, food, and nursery grounds for a variety of marine species. These forests support fisheries, improve water quality, and help to protect coastlines (Eger et al. 2024). The Sussex Kelp Recovery Project is a marine conservation effort aimed at restoring their kelp forests along the Sussex coastline in southern England. This area lost up to 96% of its forests mainly due to the fishing practice trawling. Trawling is used to gather large amounts of fish, while dragging a net at the seafloor (Our history 2026). The main goal of the Sussex …

2026 Research Day Program, Lincoln Memorial University

Research Day

This program contains abstracts and presentation summaries from LMU's 2026 Annual Research Day conference.

Effectiveness Of Common Household Water Filters In Removal Of Microplastics​, Andrew Au, Hailey Kim, Anika Prasad, Novita Whillock

Expo Student Presentations

2026 Spring Expo Poster Presentation

• Physical & Applied Sciences

Fallen Light, Joshua Do

Posters - 2026

Lucifer is often portrayed in popular media as purely evil; however, this interpretation overlooks the more complex idea of gradual moral corruption through deception and pride. The purpose of Fallen Light is to explore how doubt, pride, and subtle deception can lead even a highly exalted being away from God over time.. The game emphasizes the internal struggle between obedience and self-exaltation rather than immediate rebellion, and the problems with Being overly prideful.

Deep Learning Based Approaches For Low Cost Defense Detection, Adele J. Noel-Rickert

All NMU Master's Theses

Pulmonary fibrosis is a progressive interstitial lung disease characterized by the accumulation of fibrotic tissue within the lungs, leading to impaired respiratory function and reduced quality of life. Early detection is important for disease management; however, accurate diagnosis often relies on high-resolution computed tomography (CT), which may not be accessible in all clinical settings. Chest radiography provides a lower-cost and widely available imaging modality, but interpretation of chest X-rays for fibrotic disease can be challenging due to subtle radiographic patterns and overlapping anatomical structures. This thesis investigates the use of multimodal deep learning techniques to assist in pul- monary fibrosis …

Continuum Observations Of Water Maser Sites, Aman Khan

Theses and Dissertations from DePaul University

Stars form in cores deep within cold (10 K) clouds of hydrogen gas. As material is accreted onto the central object inside these cores (the protostar), powerful outflows that channel mass away from the protostar are also launched. The launching mechanism for these outflows is still not fully understood. This thesis presents observations of the 22 GHz continuum emission from two star-forming regions, NGC 7129 FIRS2 and IC 1396-n. The immediate aim of these observations is to find where this continuum emission is coming from, particularly if it is free-free emission from a jet or outflow, and the long term …

Factors Associated With Lapses In Care Among People Living With Hiv In South Carolina, Xueying Yang Ph.D., Fanghui Shi, Shujie Chen, Gavi Samuel, Bankole Olatosi Ph.D., Sharon Weissman, Xiaoming Li Ph.D., Jiajia Zhang Ph.D.

Faculty Publications

Utilizing statewide electronic health records (EHR) data, this study aims to assess the factors determining the occurrence of lapses in HIV care among people with HIV (PWH) in South Carolina (SC). All adult (≥ 18 years old) PWH who were diagnosed with HIV between 2006 and 2018 with at least two HIV care encounters and at least 1-year follow-up record were included in the analysis. The outcome, a lapse in care, was defined as a repeated measure of HIV care encounter that occurs over a year following the previous visit. Generalized Estimation Equation models were employed. The study cohort had …

Freedom Readers And Sustainable Development Goal 4: Advancing Literacy In Low-Income Communities Of South Carolina, Madison Hayes

Goal 4: Quality Education

No abstract provided.

Implementation And Costs Of A Food Insecurity Resource Navigation Program For Primary Care Patients With Diabetes And Hypertension In South Carolina, Deeksha Gupta, Darin Thomas, Stella Coker Watson Self Ph.D., Ms, Edward A. Frongillo Jr. Ph.D., Alain H. Litwin, Joseph A. Ewing, Lynnette Ramos-Gonzalez, Lynnette Ramos-Gonzalez

Faculty Publications

Objective

To examine food insecurity resource navigation program costs and how navigation intensity relates to clinical outcomes, healthcare costs, and quality of life (QOL) for diabetes and/or hypertension patients.

Methods

This retrospective study included patients receiving resource navigation (July 12, 2021-December 31, 2022 with twelve-month follow-up) across three primary care practices in South Carolina's largest health system. Participants were 18+ years old (from electronic medical records/Epic), had food insecurity (from Hunger Vital Sign™), and diabetes and/or hypertension (from Epic registries). Matched controls came from food insecurity screening-only practices. Patients in each group (n= 219) had diabetes (9.13%), hypertension …

Math 242: Elements Of Probability And Statistics (Syllabus), Ahmad Almomani Ph.D.

School of Arts & Sciences

This syllabus was developed by SUNY Geneseo Professor Ahmad Almomani during the spring 2026 semester.

Course Objectives:

Upon successful completion of Math 242, R/Elements of Probability and Statistics, a student will be able to: 

• Organize, present and interpret statistical data, both numerically and graphically; 
• Use various methods to compute the probabilities of events; 
• Analyze and interpret statistical data using appropriate probability distributions, e.g. binomial and normal. 
• Apply central limit theorem to describe inferences; 
• Construct and interpret confidence intervals to estimate means, standard deviations and proportions for populations; 
• Perform parameter testing techniques, including single and multi-sample tests for means, standard deviations …

A Comparative Study On Performance Of Iot-Driven Ml-Enabled Forecasting Models For Efficient Air Quality Monitoring, Bara Ksiksi

Theses

Air pollution is one of the most critical environmental challenges affecting public health globally, responsible for approximately 4.2 million premature deaths annually according to the World Health Organisation. This thesis presents a comparative study of IoT-driven machine learning forecasting models for air quality monitoring in Abu Dhabi, UAE, introducing a zonal approach combined with satellite-based spatial validation. The primary objective is to evaluate forecasting performance across three distinct activity zones using ground station data from the Environment Agency Abu Dhabi (EAD), and to incorporate a spatial validation component using satellite imagery to assess the consistency of ground-based predictions at a …

Llm-Driven Mission Control And Autonomous Planning For Search-And-Rescue Uavs: A Simulation-Based Evaluation, Naser Bader Alsaedi

Theses

Unmanned aerial vehicles (UAVs) are increasingly used in search‑and‑rescue (SAR) missions, yet many systems still rely on fragmented software where mission design, perception, and flight control are configured separately. This thesis examines whether a unified AI‑driven framework can reduce configuration effort and operator workload in UAV‑based SAR operations. The proposed system integrates natural‑language mission specification using a large language model (LLM) (LLaMA 3.1), autonomous coverage planning, YOLOv8‑based victim detection, and PX4/MAVSDK control within a single architecture. Operators describe missions through free‑form text or a graphical interface; the model converts these descriptions into structured mission parameters that are automatically planned and …

Agentspec: Customizable Runtime Enforcement For Safe And Reliable Llm Agents, Haoyu Wang, Christopher M. Poskitt, Jun Sun

Research Collection School Of Computing and Information Systems

Agents built on LLMs are increasingly deployed across diverse domains, automating complex decision-making and task execution. However, their autonomy introduces safety risks, including security vulnerabilities, legal violations, and unintended harmful actions. Existing mitigation methods, such as model-based safeguards and early enforcement strategies, fall short in robustness, interpretability, and adaptability. To address these challenges, we propose AgentSpec, a lightweight domain-specific language for specifying and enforcing runtime constraints on LLM agents. With AgentSpec, users define structured rules that incorporate triggers, predicates, and enforcement mechanisms, ensuring agents operate within predefined safety boundaries. We implement AgentSpec across multiple domains, including code execution, embodied agents, …