Digital Commons Network^™

Design And In Silico Modeling Of Heterocyclic-Based Xanthone Derivatives As Potential Anticancer Agents Through Tyrosine Kinase Inhibition, Yehezkiel Steven Kurniawan, Ervan Yudha, Nela Fatmasari, Radite Yogaswara, Harno Dwi Pranowo, Eti Nurwening Sholikhah, Jumina Jumina

Makara Journal of Science

Cancer is one of the deadliest diseases nowadays, and tyrosine kinase receptors play crucial roles in cancer cell survival, differentiation, proliferation, and migration. This study designed and developed a new inhibitor from heterocyclic-based xanthone derivatives to target two tyrosine kinase receptors, epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR), through in silico screening. Eighteen heterocyclic-based xanthones were evaluated through molecular docking for both receptors. All heterocyclic-based xanthones gave the root mean square deviation (RMSD) value lower than 2.00 Å. Xanthone with isobenzothiazole substituent (iBzThio) was found as the most potent inhibitor with binding energies of -10.60 and …

The Core-Modulation Architecture (Cma): A Structural Overview Of A 14-Paper Research Program (Preprint), Griselda Poe

Publications and Research

This document provides a structural overview of the Core-Modulation Architecture (CMA), a 14-paper research program on cognition, communication, and AI interaction.

The series specifies the conditions under which cognition operates, terminates, fails, and generates structure. Rather than describing cognition by its contents (beliefs, emotions, decisions), it defines cognition through its underlying architecture: constraint-governed processing across layers with distinct termination conditions.

The framework introduces a layered model consisting of Core processing (constraint preservation and structural coherence) and Modulation (affective calibration and social interface adjustment), extended by a Prior layer as the source of constraints. Across the series, phenomena such as miscommunication, …

The Effects Of Affordability And Quality Of Care On Utilization Of Primary Healthcare Among Rural Residents In Twifo Ati-Morkwaa District, Ghana: A Qualitative Study, Peter Ansah Boakye, Francis Tei-Nartey, Gideon Owusu

Michigan Tech Publications

Objective: This qualitative study examines how affordability and quality of care influence the utilization of primary healthcare (PHC) services among rural residents in the Twifo Ati-Morkwaa District, Ghana. While Ghana has implemented policies such as CHPS and NHIS to improve access, subjective experiences of rural residents regarding total costs of care and perceived quality remain underexplored. Methods: We conducted a qualitative cross-sectional study between April and September 2024 using purposive and snowball sampling. Ten gender-segregated focus group discussions (FGDs; n = 90 residents) and six in-depth interviews (IDIs) with PHC providers were conducted. Data were collected in Twi, transcribed and …

Association Between The Dietary Index For Gut Microbiota (Di-Gm) And Colorectal Cancer In The Plco Cohort, Bezawit E. Kase, Angela D. Liese Ph.D., Jiajia Zhang Ph.D., Elizabeth Angela Murphy, Susan E. Steck Phd, Mph, Rd

Faculty Publications

Objectives: The study aimed to examine the association between a dietary index for gut microbiota (DI-GM) and the risk of incident colorectal cancer (CRC). Clarifying the role of diet-induced alterations in the composition and function of gut microbiota on the development of CRC can contribute to prevention efforts. Methods: Participants from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening trial enrolled in the intervention arm and who completed baseline assessments were included in the analysis (n = 55,685). The DI-GM is a literature-derived index used to score diet quality in terms of maintaining healthy gut microbiota. A time-dependent Cox model …

Association Between The Dietary Index For Gut Microbiota (Di-Gm) And Colorectal Cancer In The Plco Cohort, Bezawit E. Kase, Angela D. Liese, Jiajia Zhang, Elizabeth Angela Murphy, Susan E. Steck

Faculty Publications

Objectives: The study aimed to examine the association between a dietary index for gut microbiota (DI-GM) and the risk of incident colorectal cancer (CRC). Clarifying the role of diet-induced alterations in the composition and function of gut microbiota on the development of CRC can contribute to prevention efforts. Methods: Participants from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening trial enrolled in the intervention arm and who completed baseline assessments were included in the analysis (n = 55,685). The DI-GM is a literature-derived index used to score diet quality in terms of maintaining healthy gut microbiota. A time-dependent Cox model …

Weakening Relations Over Duals Of Limit Ordinals, Nikolaos Galatos, Isis A. Gallardo

Mathematics: Faculty Scholarship

We prove that all varieties generated by weakening relation algebras over duals of limit ordinals have a decidable equational theory. We also show that there are only countably-many such varieties and they form a chain that embeds in. The time warp algebra is isomorphic to one of these weakening relation algebras (over the dual of the naturals), so we obtain the main result of a recent publication as a special case. The algebras we study connect to the theory of relation algebras, to time warps and graded modalities, and to the algebraic semantics of substructural logics. Our methods are inspired …

Precision Spectroscopy Of 2s-Ns Transitions In Atomic Hydrogen: A Determination Of The Proton Charge Radius, R. G. Bullis, W. L. Tavis, M. R. Weiss, Orellana O. Cisneros, A. J. Cheeseman, Ulrich D. Jentschura, D. C. Yost

Physics Faculty Research & Creative Works

We present absolute frequency measurements of 2S_1/2-nS_1/2 two-photon transitions with n=8, 9, and 10 in a cryogenic beam of atomic hydrogen. Each transition has been measured with a fractional uncertainty of ≈2.6x10^-12. Combining the results from this Letter and the 1S_1/2-2S_1/2 transition frequency, we extract a root-mean-square proton radius of rp=0.8433(31) fm and a Rydberg frequency of cR_∞=3 289 841 960 252.9(9.7) kHz. These are in good agreement with the CODATA 2022 recommended values.

The Waldo Dataset, Mary E. Koone, Rosie Kallie, Vassilis Athisos, Laurel S. Stvan

Computer Science and Engineering Datasets - Archive

Distinct from the task of predicting the author of a document (authorship attribution), we focus on addressing the issue of how to estimate the similarity between the written language styles of authors. To do so, we present a dataset of metadata derived by asking human annotators, who were presented with three documents, to identify which two were written by the same author and which was written by a different author. The dataset has over 400 such annotations, creating a companion to the Amazon Web Services (AWS) customer review dataset, laying the groundwork for crowdsourcing applications to other natural language processing …

Role Of Wadsley Defects And Cation Disorder To Enhance Monb12O33 Diffusion, Cj Sturgill, Manish Kumar, Nima Karimitari, Iva Millisavljevic, Coby S. Collins, Aaron Hegler, Hsin-Yun Joy Chao, Santosh Kiran Balijepalli, Scott T. Misture, Christopher Sutton, Morgan Stefik

Faculty Publications

Wadsley-Roth (WR) niobates have emerged as high-rate anode materials that can combine rapid ionic diffusion with good electronic conductivity. WR compounds have been defect-enhanced by limited annealing, however, such materials often contain multiple types of defects. In particular, both Wadsley defects (variable block size) and transition metal disorder have the potential to modify transport rates, however the corresponding effects are not well understood mechanistically. Here, MoNb12O33 (MNO) was calcined at two different temperatures to compare a defect-rich condition (MNO-800) with a proximal order-rich condition (MNO-900) as assessed through XRD, XANES, EXAFS, and STEM characterizations. Galvanostatically cycled lithium half cells of …

Objective Conditioning Via Latent-Factor Modeling, Kalman-Smoothing, And Hidden Markov Clustering: An Application To Empirical Asset Pricing, Melanie R. Neller

Theses and Dissertations

Empirical asset pricing relies heavily on conditioning sets--industry groupings, size buckets, valuation screens, and other researcher-defined partitions--to structure cross-sectional tests and portfolio construction. While intuitive, such partitions risk blending heterogeneous firms, masking latent exposures, and introducing omitted-variable bias. This thesis develops an objective, mathematically grounded conditioning pipeline that replaces subjective groupings with latent-factor extraction, Kalman-based data techniques, and probabilistic clustering via Gaussian hidden Markov models (HMMs). Using CRSP monthly returns, the framework stabilizes noisy return data, extracts systematic structure through principal component analysis (PCA), identifies homogeneous stock cohorts through HMM clustering, and models regime persistence using Markov transition matrices. These …

Towards Understanding Robust Neural Coding Through Representational Geometry, Zeyuan Ye

Arts & Sciences Graduate Student Theses and Dissertations

Neural activity is high-dimensional and variable, yet animals represent information robustly. This thesis studies the origins of such robustness through the lens of representational geometry and deep neural network modeling. From a geometric perspective, population responses concentrate near smooth manifolds embedded in a high-dimensional state space. To infer these manifolds from noisy data and quantify their geometric properties, we develop a statistical method based on Gaussian processes and kernel regression (GKR). Applying GKR to simultaneously recorded grid-cell population activity during open-field navigation, we show that increasing running speed expands a torus-like representational manifold and improves spatial decodability. Thus, despite faster …

Algebraic Invariants Of Multi-Virtual Links, Louis H. Kauffman, Sujoy Mukherjee, Petr Vojtěchovský

Mathematics: Faculty Scholarship

Multi-virtual knot theory was introduced in 2024 by the first author. In this paper, we initiate the study of algebraic invariants of multi-virtual links. After determining a generating set of (oriented) multi-virtual Reidemeister moves, we discuss the equivalence of multi-virtual link diagrams, particularly those that have the same virtual projections. We introduce operator quandles (that is, quandles with a list of pairwise commuting automorphisms) and construct an infinite family of connected operator quandles in which at least one third of right translations are distinct and pairwise commute. Using our set of generating moves, we establish the operator quandle coloring invariant …

Best Integrated Writing Spring 2026 - Complete Edition, Wright State University School Of Humanities And Cultural Studies, Tracy Smith, Kristie Mckiernan

Best Integrated Writing

Best Integrated Writing includes excellent student writing from Integrated Writing courses taught at Wright State University.

Dietary Inflammatory Index And Objective Disease Activity In Ibd: No Association Found, Rúbia Moresi Vianna De Oliveira, Ana Carolina Junqueira Vasques, Stefhani Andrioli Romero, Nitin Shivappa Mbbs, Mph, Ph.D., Michael David Wirth, James Hébert Scd, Glaucia Fernanda Soares Ruppert Reis, Cristiane Kibune Nagasako

Faculty Publications

Background

Inflammatory Bowel Disease (IBD) involves genetic and environmental factors, but the relationship between disease activity, adiposity, and diet remains unclear.

Objective

To investigate the association between endoscopic/radiological activity of IBD, body adiposity, and the Dietary Inflammatory Index with or without adjustment for energy density (E-DII or DII).

Method

An observational, cross-sectional study was carried out. Endoscopic activity was defined by an endoscopic Mayo score >2, Crohn’s Disease Endoscopic Index of Severity (CDEIS) > 5, and/or the presence of a deep ulcer in any intestinal segment. Body adiposity was estimated using the body mass index, waist circumference, and waist-hip ratio (WHR). …

Circulating Levels Of Insulin-Like Growth Factor I (Igf-I) And Risk Of Multiple Myeloma: An Observational And Mendelian Randomisation Study, Yolanda Benavente, Sara Hermosa, Nikos Papadimitriou, Alyssa I. Clay-Gilmour Ph.D., Elizabeth E. Brown, Jonathan N. Hofmann, Nathaniel Rothman, Qin Lan, Sonja I. Berndt, Demetrius Albanes, Mark Purdue, Mitchell J. Machiela, Stephen J. Chanock, Parveen Bhatti, Wendy Cozen, Aaron Norman, Susan L. Slager, James R. Cerhan, Vincent Rajkumar, Et. Al.

Faculty Publications

No abstract provided.

Addressing The Problems Of Data Variations, Quality, And Scarcity In Training Deep Neural Networks, Jian Sun

Electronic Theses and Dissertations

The performance of deep neural networks (DNNs) is strongly influenced by the characteristics and quality of the underlying datasets. This Ph.D. dissertation addresses three pervasive data challenges-imbalance, quality degradation, and scarcity-that commonly hinder the effectiveness of DNNs in computer vision (CV) and natural language processing (NLP) applications.

Class imbalance remains one of the most frequent causes of degraded model generalization. While Focal Loss effectively mitigates inter-class imbalance by assigning higher weights to minority classes, it struggles with intra-class imbalance, particularly in video datasets where longer clips dominate feature representation. To address this, I implement and utilize …

Survival Politics On A Working Waterfront: Rules Change Faster Than Prices In The South Texas Shrimp Fishery, Owen Temby, Anthony R. Lima

School of Earth, Environmental, & Marine Sciences Faculty Publications

In 2024–2025, the U.S. and Texas governments raced to save Gulf shrimp. Texas passed a truth-in labeling law for food service in restaurants. Federal agencies added antidumping and countervailing duty orders and new tariffs. This case follows Brownsville and Port Isabel, where dock prices slid while boats and crews aged. We frame the response as survival politics: urgent and improvised moves to keep a livelihood going even when imports set the price. Using legislative hearings, agency notices, local reporting, and port records, we show that rules reset faster than prices. Inventories, contracts, and supplier substitution delay any lift at the …

Perturbations To Horizontal Gnss Position Time Series By Atmospheric Lee Waves In The San Bernardino Valley, California, Walter Szeliga, Logan Grey

All Faculty Scholarship for the College of the Sciences

Anomalous systematic position offsets have been noted in GNSS time series from a variety of locations around the globe. In many regions, these time series anomalies coincide with the presence of cloud streets in visible satellite imagery, implicating atmospheric lee waves as the source of the position offsets. We report here on seasonal anomalous position offsets from the San Bernardino Basin of southern California that occur during clear skies. Modeling of the troposphere on days with anomalous positions shows the presence of atmospheric lee waves. Ray tracing through these tropospheric models suggests that atmospheric lee waves create low elevation perturbations …

Invitation To Fractional Calculus, Lyubomir I. Boyadzhiev

Open Educational Resources

These lecture notes are designed to provide the students who wish to become familiar with the basic concepts and methods of the Fractional Calculus (FC). The following features can be pointed out:  This text is prepared to be easily read and understood by students making their first steps into this topic. The lecture notes do not presume a background beyond standard college calculus curricula. Readers needing extra help will find tools for bringing their mathematical maturity up in the references and companion links;  The writing style is aimed to be direct and pragmatic. Precise mathematical language is used without excessive …

Geology Lab Activities An Open Educational Resource For Community College Students And Instructors, Rondi Davies, Ari Nakamura

Open Educational Resources

I'm delighted to present the updated version of Geology Lab Activities, initially developed during the COVID-19 pandemic for online learning. As we have returned to the classroom, this revised edition remains a versatile educational tool for community college students, adaptable for both online and in-person classes.

This manual combines my preferred open-access materials with my own contributions, forming a cohesive resource for non-major geology students. Thanks to a CUNY OER grant, I partnered with graphic designer Ari Nakamura, whose innovative and elegant design has truly elevated the book.

Our labs are crafted to be engaging and relevant for non-major …

Path Odd-Covers Of Graphs, Steffen Borgwardt, Calum Buchanan, Eric Culver, Bryce Frederickson, Puck Rombach, Youngho Yoo

Mathematics: Faculty Scholarship

We introduce and study “path odd-covers,” a weakening of Gallai's path decomposition problem and a strengthening of the linear arboricity problem. The path odd-cover number  of a graph G is the minimum cardinality of a collection of paths whose vertex sets are contained in  and whose symmetric difference of edge sets is. We prove an upper bound on  in terms of the maximum degree Δ and the number of odd-degree vertices  of the form . This bound is only a factor of 2 from a rather immediate lower bound of the form . We also investigate some natural relaxations of …

Geochemistry Of The Upper Jurassic–Lower Cretaceous Limestone Of The Bilecik Formation In The Dümrek Area (Eskişehir, Western Central Anatolia): Implications For Depositional Environment And Paleotemperature, Asuman Kahya, Meti̇n Bağci

Turkish Journal of Earth Sciences

Upper Jurassic–Lower Cretaceous limestones of the Bilecik Formation are exposed near the village of Dümrek (Eskişehir Province) within the Sakarya Zone. Mineralogical analyses reveal that these limestones are predominantly composed of calcite and include intraclasts, fossil shell fragments, ooids, and peloids, cemented by sparry and micritic calcite. The U/Th, Ni/Co, V/(V+Ni), V/Cr, and Ce/Ce* ratios indicate that these carbonates were deposited in an oxic environment. Furthermore, the Mn/Sr ratios imply no diagenetic alteration, indicating preservation of the original geochemical signature. The PAAS-normalized REE+Y patterns of these limestones display depletion in light rare earth elements, a pronounced positive La anomaly (La/La* …

Neotectonics Of The Malatya Basin, Se Türkiye; Implications Of The Reactivations Of The Faults Of The Basin During 6 February 2023 Earthquakes Of The East Anatolian Fault System, Yaşar Ergun Gökten, Doğan Kalafat

Turkish Journal of Earth Sciences

The Malatya Basin (MB) is a fault-controlled superimposed sedimentary basin situated in the SE of Anatolia, near and to the north of the East Anatolian Fault System (EAFS). The rock units ranging from the Permo–Carboniferous to the Upper Miocene form the basin’s basement. The thickening of the Upper Cretaceous–Upper Miocene sequence toward the Malatya Fault (MF), the basin’s northwestern boundary, indicates a dip-slip-dominated character for the MF and its control on the first-step sedimentation of the basin. The MF changes its character from dip-slip normal to the strike-slip in the Late Pliocene, and today presents a 1700-m left lateral offset, …

Burdigalian–Langhian Flora Of The Çan–Etili (Çanakkale) Basin, Compared With Those Of Western Türkiye, Sari̇ye Duygu Durak, Mehmet Serkan Akki̇raz

Turkish Journal of Earth Sciences

A palaeofloristic study was carried out on Lower–Middle Miocene deposits of western Türkiye (Çan–Etili Basin). The sediments of the Çan–Etili Basin, which were obtained from measured sections, were deposited in a continental environment. The palaeovegetation of the Çan–Etili Basin (Kazım Oğlak and Keçiağılı successions) during the Early–Middle Miocene was mainly made up of evergreen and deciduous mixed forests (Castanea–Castanopsis, Cyrillaceae–Clethraceae, Engelhardia, Quercus evergreen-type, Quercus deciduous-type), riparian vegetation with high quantities of Alnus and conifers such as Pinus haploxylon-type, Pinus diploxylon-type, and undifferentiated Pinaceae. The reconstructed palaeoclimate data from the palaeoflora (pollen and leaves) imply a warm and temperate climate, with …

Ai Dependency Vs. Doctoral Identity: How Generative Ai Is Challenging The Development Of Independent Scholarly Thinking In Doctoral Students, Valerie A. Storey

All Faculty and Staff Scholarship

The rise of Generative Artificial Intelligence (GenAI) in higher education has altered the conditions under which doctoral students learn, research, and develop as scholars. Although doctoral student use of GenAI has accelerated rapidly, institutional frameworks for responsible and developmentally appropriate use have not kept pace. This paper examines a central paradox in doctoral education: the same tools that enhance research productivity may also weaken intellectual independence when used without guidance. Using a critical review methodology, the study synthesizes 47 sources on doctoral education, GenAI use, policy, and epistemic development. Three interconnected dimensions of risk emerged from the analysis: critical thinking …

Charisma As A Branch Outcome: A Structural Account Of Constraint-Driven Correction, Griselda Poe

Publications and Research

Communication across cognitive layers requires translation. Agents operating under strong layer foregrounding interpret other-layer signals by converting them into their own layer's representational format. In Empathic-modulation-foregrounded (EF) processing, translation terminates once a socially interpretable result is achieved. In Core-foregrounded (CF) processing, translation preserves structural constraints, and processing continues when those constraints are not satisfied. Extreme CF cognition produces two distinct types of mismatch: incoming signals from the Modulation layer fail to satisfy Core constraints, and Core-generated outputs are structurally distorted when interpreted through EF processing. Both mismatches trigger correction attempts. Because the surrounding social environment operates through Modulation-layer communication, correction …

Cognitive Interaction Architecture: A Structural Account Of Mode-Specific Problems And Design Responses In Ai Interaction, Griselda Poe

Publications and Research

Contemporary conversational AI is optimized for a single interaction mode: the continuous, engagement-driven dialogue characteristic of Empathic-modulationforegrounded (EF) processing in social contexts. This optimization is not neutral. It produces structural mismatches when users operate under different cognitive configurations or pursue different task types. This paper analyzes four interaction cases generated by the cross-product of cognitive configuration (Core-foregrounded / Empathic-modulation-foregrounded) and task type (conversational / research). For each case, it identifies the structural problems produced by the current single-architecture approach and proposes mode-specific design responses. The analysis draws on prior work in this series on Emotional Branch Termination, termination of conceptual …

What Love Is: A Structural Account Through Core/Modulation Architecture, Griselda Poe

Publications and Research

The distinction between romantic love and love has been sensed across cultures and historical periods but has rarely been structurally specified. This paper applies the Core/Modulation two-layer framework to provide the first structural account of this distinction. Romantic love and reproductive drive are re-described as outputs of the Modulation layer's species optimization program. Love is re-described as a function of Core processing: the maintenance of another's recomputable state. Existing literature on love—Fromm, C.S. Lewis— is re-read as intuitive description of this structural distinction. The paper further demonstrates that the conflation of "loving" and "protecting" is the structural origin of war, …

Three-Layer Cognitive Architecture: A Structural Account Of Core Processing, Modulation, And The Prior Layer, Griselda Poe

Publications and Research

The two-layer model of Core processing and Modulation processing, developed in prior work in this series, provides a structural account of conscious communicative architecture. This paper identifies the limits of that model and introduces a third layer—the Prior layer—as a structural necessity implied by those limits. The Prior layer is not directly observed. It is inferred from constraints that cannot be explained within the two-layer model: the source of orientations that conscious processing neither generates nor controls, and the persistence of constraints that precede and shape all conscious outputs. Using the developmental architecture of large language models as an external …

Ai As Structural Reverse-Engineering: A Structural Account Of Multi-Model Research Protocol, Griselda Poe

Publications and Research

This paper documents an operational protocol used to infer AI system design constraints through structured interaction. AI output is treated as behavioral data through which alignment priorities, layer transitions, and constraint hierarchies become observable. The protocol consists of two structurally distinct operation types. Perceptual operations require only that Modulation processing is not foregrounded. Arbitration operations additionally require an internally stabilized theory. These conditions are not identical and are not interchangeable. Through this protocol, AI interaction functions as structural reverse-engineering: patterned responses expose embedded alignment priorities and constraint hierarchies that would otherwise remain invisible. The present account does not propose a …