Digital Commons Network^™

Establishing A Comprehensive Framework For Sfrt Lattice Treatments: Optimization, Planning, And Clinical Evaluation, Gregory M. Gill

UNLV Theses, Dissertations, Professional Papers, and Capstones

Spatially fractionated radiation therapy (SFRT) using lattice radiotherapy (LRT) has emerged as a promising treatment technique for bulky, nonresectable tumors by delivering spatially heterogeneous dose distributions consisting of high-dose vertices embedded within lower-dose regions. Although early clinical experiences have demonstrated potential therapeutic benefit, widespread clinical implementation of LRT remains limited due to the absence of standardized treatment planning workflows, consistent optimization strategies, and clearly defined evaluation metrics for heterogeneous dose distributions. The objective of this study is to develop and evaluate a structured framework to support efficient, reproducible, and safe clinical implementation of LRT.

To address these challenges, a comprehensive …

A Modified Maximum Likelihood Estimation Algorithm For Modeling Threshold Exceedances With The Generalized Pareto Distribution, Jeffrey Harkness

UNLV Theses, Dissertations, Professional Papers, and Capstones

A modified maximum likelihood estimation (MLE) algorithm is proposed for modeling threshold exceedances with the generalized Pareto distribution (GPD). The algorithm addresses multiple issues with an approach originally published in the Journal Computational Statistics and Data Analysis (Castillo and Serra, 2015). The modified algorithm is intended to be comparatively simple to understand and implement, accurate in the handling of boundary conditions, relatively fast and reliable for most data sets, and relatively easy to transfer between computer languages by leveraging existing optimization routines.

A reproducibility study of work in recent literature published in the journal Extremes (Belzile, et al., 2023) is …

Exact Solution Of Steady Seepage In An Asymmetrical Domain Underneath A Cofferdam, Tan Nguyen

UNLV Theses, Dissertations, Professional Papers, and Capstones

For decades, the evaluation of steady state seepage beneath asymmetrical cofferdams has relied on numerical methods, such as Finite Element Methods (FEM), Finite Difference Method (FDM), Finite Volume Method (FVM), Mesh Reduction Method (MRM), Meshless Method (MM), Boundary Element Method (BEM), or geometric idealizations, most notably Griffiths' vertical Method of Fragments assumption. While exact closed form solutions via Schwarz-Christoffel (SC) conformal mapping have been well established for symmetrical geometries (Banerjee and Muleshkov), the generalized asymmetrical case has historically remained an intractable mathematical frontier. The primary barrier to an exact analytical solution has been the "crowding problem," a numerical phenomenon where …

Methylation-Dependent Regulatory Pathway That Governs The Stability Of The Sox Family Proteins And Related Developmental Regulators, Keshari Gayathri Rajawasam

UNLV Theses, Dissertations, Professional Papers, and Capstones

The SRY (Sex-determining Region Y) protein is a transcription factor encoded on the Y chromosome and is the key regulator responsible for initiating male sex determination in mammals. During early embryonic development, SRY activates the genetic program that leads to testis formation by promoting the expression of downstream genes involved in male gonadal differentiation. Mutations or dysregulation of SRY can lead to disorders of sex development such as male-to-female sex conversion and hermaphroditism, highlighting its critical role in sex determination.

SRY belongs to the SOX (SRY-related HMG-box) family of transcription factors, which includes the proteins SOX1, SOX2 and SOX3. These …

Fast Radio Bursts And Long Period Radio Transients: Radiation Mechanisms And Propagation Effects, Yuanhong Qu

UNLV Theses, Dissertations, Professional Papers, and Capstones

Fast Radio Bursts (FRBs) are bright radio bursts with the highest brightness temperatures in the radio sky. In this thesis, we investigate the trigger mechanisms, radiation mechanisms, and propagation effects of FRBs. Two general classes of coherent radiation mechanisms are considered in two categories: pulsar-like models invoking emission originating within the magnetar magnetosphere, and GRB-like models, which attribute the emission to relativistic magnetized shocks occurring far away from the central engine. We use the general observed properties (polarization features and spectra bandwidths) of repeating FRBs to constrain the physical conditions needed for these two mechanisms. We propose that crust quakes …

Visual Interpretability Of Multimodal Tissue Perfusion Classification Using Grad-Cam And Saliency Maps, Metehan Zorluoglu

UNLV Theses, Dissertations, Professional Papers, and Capstones

Accurate identification of the tissue perfusion phase from hand images can aid doctors in decision-making with non-invasive techniques. The present study proposes a multimodal deep learning model for classifying the tissue perfusion phase using infrared, thermal, and visible spectrum images of the human hand. The proposed model consists of various preprocessing techniques such as manipulation, homography alignments, and masking. The significant contribution of this thesis is the interpretability analysis of deep learning models, achieved through the analysis of saliency maps and the Gradient-weighted Class Activation Mapping (Grad-CAM) methods. The purpose of this method is to find out how the convolutional …

Phase Field Modeling And A Fully Discrete Numerical Scheme For Two-Phase Incompressible Mhd Flows With Different Densities, Electric Conductivities And Viscosities, Xiaoyong Chen, Rui Li, Jian Li, Xiaoming He, Yanping Lin

Mathematics and Statistics Faculty Research & Creative Works

This article establishes a phase field model for governing the two-phase incompressible MHD flows with different densities, electric conductivities, and viscosities. In addition to the coupling between the Cahn–Hilliard phase field equations and the single-phase MHD equations together with the varying parameters, it is physically faithful and mathematically rigorous for the modeling to incorporate a relative flux term, which is related to the diffusion of the components, into the coupled system, inspired by Abels et al. and Shen and Yang. We present a linear fully discrete numerical scheme for this complex multi-physics system, which leverages the artificial compressibility method, an …

Digital Literacy And Language Proficiency As Factors Of Accessible Digital Training In The Hospitality Industry: Employee Perspectives Of Training And Working In A Diverse Industry, Gillian Bowden

UNLV Theses, Dissertations, Professional Papers, and Capstones

This explanatory sequential mixed methods study explored how digital literacy and language proficiency impact employees’ access to and engagement with digital training, as well as how these experiences influence their perceptions of training and the organization. In the quantitative phase, survey data were collected from hourly employees at a large foodservice corporation (n=67). Four constructs were assessed: digital literacy, language proficiency, accessibility, and engagement. Results indicated strong, statistically significant relationships with higher levels of digital literacy and language proficiency associated with greater accessibility and increased engagement with digital training materials. The large effect sizes suggest these competencies play a meaningful …

Iterative Silver-Label Refinement For Temporal Information Extraction In Biomedical Literature, Chan Lee

UNLV Theses, Dissertations, Professional Papers, and Capstones

Temporal information extraction plays a critical role in the biomedical domain, where the ability to identify events and their temporal relationships is central to interpreting research findings. However, annotated corpora for this task remain scarce and costly to produce and the existing models developed for clinical text do not transfer well. This work bridges that gap through iterative silver-label refinement. A temporal model originally trained on news-domain data is adapted to biomedical text through cycles of automatic labeling, targeted correction, and retraining without the need for comprehensive manual annotation.

Key contributions include a practical iterative refinement methodology demonstrating that the …

From Flight To Hatching: Adult Sexual Dimorphism, Life History, And Egg-Stage Ecology Of Pseudocotalpa Giulianii, Mandylene Mountain

UNLV Theses, Dissertations, Professional Papers, and Capstones

The Nevada endemic dune beetle Pseudocotalpa giulianii is currently known only from two dune systems in Amargosa Valley, Nevada, yet much of its life cycle occurs below the sand surface and remains poorly documented. This thesis addresses key gaps in adult-stage biology and egg-stage development that are relevant to understanding reproduction, vulnerability, and habitat requirements in this dunerestricted species.

To characterize adult sexual dimorphism and life history, I quantified morphological differences between males and females and measured sex-specific adult survival under laboratory conditions relative to the aboveground flight season. Males and females overlapped broadly in external body size, but tarsal …

Effect Of The Sava Syndemic On Hiv Viral Suppression Among People Living With Hiv In The United States: A Scoping Review And Meta-Analysis, Jacquelyn Rodriguez

UNLV Theses, Dissertations, Professional Papers, and Capstones

The SAVA syndemic highlights the interconnected and mutually reinforcing nature of substance use, violence victimization, and HIV/AIDS. The synergistic interaction of these conditions creates structural and behavioral barriers that disrupt the HIV care continuum and contribute to significant health inequities. Achieving a suppressed viral load is a critical clinical outcome for people living with HIV, while viral non-suppression can be an indicator of poor health, elevated transmission risk, and disease progression. Still, the association between SAVA factors and viral suppression/non-suppression outcomes within U.S. populations remains inconsistently characterized due to heterogeneous methodologies and variable inclusion of high-risk groups. This mixed-methods study …

At The Crossroads Of Traditional And Nuclear Forensics: Decontaminating Radiologically Contaminated Dna Evidence Using Magnetic Beads, Rin Nyx Ruby

UNLV Theses, Dissertations, Professional Papers, and Capstones

Known for its impressive discriminatory power, deoxyribonucleic acid (DNA) fingerprinting stands as the “gold standard” of forensic investigation. However, complications arise when such evidence is contaminated with radioactive material. Though biological samples exposed to ionizing radiation can still yield comprehensive DNA profiles, most forensic laboratories lack the facilities which meet the safety and security requirements necessary for handling radioactive material. While nuclear facilities can decontaminate samples prior to forensic analysis, conventional methods for radiological decontamination – such as mechanical cleaning and chemical washes – may degrade the quality of the forensic evidence. The purpose of this study is to evaluate …

2d And 3d Insights Into The Formation And Emplacement Of Martian Meteorites, Sierra Rhaye Ramsey

UNLV Theses, Dissertations, Professional Papers, and Capstones

Martian meteorites are the only samples currently available from Mars, making their study critical for understanding martian igneous processes. Despite extensive study over the last five decades, the formation (e.g., mantle sources, crystallization pressures), emplacement (e.g., intrusive versus extrusive), and shock histories of these rocks remain uncertain due to their innate lack of geologic context and limited petrologic tools calibrated for martian conditions. This dissertation analyzes a large suite of 22 igneous martian meteorites using complementary 2D and 3D analytical methods to better constrain the magmatic, emplacement, and shock processes responsible for their formation and ejection from Mars.

Chapters 2 …

Shelters In Motion, Erin Nicole Vallido Trasmano

Hospitality Design Graduate Student Capstones

Shelters in Motion is a modular temporary shelter system for festival and outdoor events that replaces disposable tents with reusable, durable design. Overall reducing environmental impact while significantly improving comfort and user experience.

The Origins Of Chondrite Families, Isabelle M. Perron

UNLV Theses, Dissertations, Professional Papers, and Capstones

Chondrites, a type of primitive asteroid, are thought to have formed from dust and gas early in the life of our Solar System. These chondrites have remained unchanged since their formation, avoiding being melted or differentiated like other rocky bodies have. Due to this unique characteristic, chondrites can give us useful insight into how asteroids, planetesimals, and even the terrestrial planets formed. In order to study chondrites and their formation, I used code developed by Li et al. (2020), which utilizes thermodynamic code GRAINS (Petaev 2009), to see what conditions the chondrites may have originated from. GRAINS uses a variety …

Preservation Of Sedimentary Rubidium Isotopic Signatures In Subduction Zones: Insights From The Schistes Lustrés Hp-Uhp Metasediments, Western Alps, Mary Clarich

UNLV Theses, Dissertations, Professional Papers, and Capstones

When oceanic plates bend and sink into the mantle at subduction zones, they carry sediments from the surface down into the mantle. The recycled sediments contain elements, that are depleted in the mantle, thereby influencing the composition of the mantle wedge and the formation of arc magmas, which are the building blocks of juvenile continental crust. However, it remains poorly constrained how much these elements, particularly fluid-mobile elements such as rubidium (Rb), are lost into fluids during metamorphic dehydration, and how much is transported to sub-arc depths where arc magmas are generated. Rubidium in subducting sediments is mainly hosted in …

Harnessing Backcasting To Identify Drivers Of Critical Warming At Hoover Dam Using Hydrodynamic And Machine Learning Models, Eunice Ledres

UNLV Theses, Dissertations, Professional Papers, and Capstones

Elevated water temperatures can pose a significant threat to dam infrastructure, potentially damaging turbines, overheating internal components, and forcing generator shutdowns. This study uses a backcasting framework to evaluate how future scenarios may result in elevated water temperatures. Backcasting defines undesirable outcomes and works backward to identify the conditions that lead to them. The developed backcasting framework integrates 3D physics-based simulations with a Long-Short Term Memory (LSTM)surrogate model and SHapely Additive exPlanations (SHAP) interpretation. The combination captures temporal water temperature dynamics and quantifies the contributions of different drivers to elevated water temperature releases. As proof of concept, these methods are …

Constructing A Laser Stabilization System For Frequency Metrology, Stephanie Letourneau

UNLV Theses, Dissertations, Professional Papers, and Capstones

Frequency metrology and quantum control, which uses light as a tool for measurement and manipulation, relies on spectrally narrow, stable lasers. Often thought of as being perfectly monochromatic and coherent, in reality, the free-running instantaneous linewidth of lasers can be on the order of hundreds of kHz in the millisecond time-frame and drift on the order of tens of MHz over hours. To correct for these instabilities in real-time, a variety of laser stabilization methods have been implemented, including the Pound-Drever-Hall (PDH) method, saturation absorption spectroscopy (SAS), and dichroic atomic vapor laser locking (DAVLL). All of these methods rely on …

Thermal Physiological Ecology Of The Relict Leopard Frog At Hot And Cold Springs, Robert P. Pelletier Iii

UNLV Theses, Dissertations, Professional Papers, and Capstones

The relict leopard frog (Rana onca) once ranged across drainages in southern Nevada, northwestern Arizona, and southwestern Utah. Following a decline, the species only persisted in a few geothermally influenced hot springs, which led to the perspective that hot springs were high-quality habitat. Rana onca has been under intensive, multiagency management and the species has been translocated to establish additional populations, including at cold-water sites. Three research studies are presented into the thermal physiological ecology of R. onca with the aim of informing conservation strategy. The research was focused at a thermally influenced hot spring and a cold-water spring to …

Cold Plasma Treatment Of Hydroponically Grown Basil: Effects On Essential Oil Composition For Sustainable Applications (Ocimum Basilicum), Judith Serwaa Marfo

Seton Hall University Dissertations and Theses (ETDs)

Abstract Essential oils are known to have medicinal benefits and pharmaceutical applications. This study investigates the impact of cold plasma treatment on hydroponically cultivated basil (Ocimum basilicum), focusing on physical growth traits, and essential oil composition. Preliminary trials validated our solvent extraction protocol using IPA, hexanes, and methanol without heat on store-bought basil. Rotary evaporation and GC-FID analysis successfully identified key compounds; eugenol, estragole, eucalyptol, and linalool. Plasma-treated hydroponic plants exhibited enhanced physical characteristics, including larger leaves and intensified green pigmentation, compared to untreated controls under identical conditions. The plasma treatment didn't just increase how much oil was extracted, but …

Semi-Rational Strategies For Antifungal Peptide Design, Akilah I. Mateen

Seton Hall University Dissertations and Theses (ETDs)

A recently emerged opportunistic fungi, Candida auris, has been subject to increased scrutiny due to its virulence and rapid geographical spread. Due to the indiscriminate use of antimicrobials as treatments for infectious diseases and as pesticides, the ubiquitous threat of multidrug resistance (MDR) looms large. The lack of progress in antifungal development is of high concern in the treatment of infectious diseases and a rise in fungal resistance highlight the need for updated treatment strategies. This work describes three strategies used to address these concerns:

•  The synthesis of a photosensitizer-membrane-active peptide (PS-MAP) conjugate, Ir-HKII15, that combines the ability of …

Phase Identification Of (La, Sr)Coo3 Solid Oxide Cell Electrode Films Using Dft Based Exafs, Musab A. Siddiqui

Seton Hall University Dissertations and Theses (ETDs)

Perovskite structured mixed ionic electronic conductor (MIEC) materials formed as films by metal-organic precursor deposition have excellent electrochemical performance in solid oxide cell (SOC) air electrode applications due to the large surface area provided by the manufacturing approach. MIEC films created by metal organic precursor deposition are often multi-phased due to low heat treatment temperatures and locally generated low oxygen partial pressures caused by the release of carbonaceous gases during the drying step of the fabrication process. In this work, we use extended x-ray absorption fine structure spectroscopy (EXAFS) to examine the phase contents of La0.8Sr0.2CoO3 (LSC82) and La0.6Sr0.4CoO3 (LSC64) …

Beyond English: Auditing And Mitigating Cross-Lingual Data Contamination In Multimodal Large Language Models, Pavan Dharma Adapa

Theses and Dissertations

This thesis extends data contamination auditing for multimodal large language models to multilingual settings. Using LLaVA 1.5 and a high-fidelity French parallel dataset derived from ScienceQA, the study evaluates how performance changes when identical image-question pairs are translated from English to French. The resultsshow a substantial cross-lingual performance decline and frequent flips from correct English predictions to incorrect French predictions, indicating that benchmark performance can depend heavily on memorized English-specific patterns rather than stable multimodal reasoning. To address this weakness, the thesis introduces an inference-time mitigation strategy based on perturbation ensembling and cross-lingual consistency aggregation. The proposed method reduces instance-level …

Evaluation And Mitigation Of Bias And Toxicity In Open-Source Large Language Models Using Crows-Pairs And Bold, Sai Harika Gade

Theses and Dissertations

This thesis evaluates bias and harmful language generation in five open-source language models and tests practical mitigation methods that do not require retraining. Two masked models are assessed with a sentence-pair benchmark for stereotype preference, and three generative models are assessed with a prompt-based benchmark for harmful continuations across demographic domains. The study uses a unified experimental workflow to compare model behavior, summarize differences across bias categories, and measure changes after intervention. Results show that the masked models favor stereotypical content above a random baseline, while the generative models usually produce low average toxicity but still show uneven risk across …

Accelerating Defensive Cyber Operations Via Unsupervised Log Clustering And Automated Regex Template Synthesis, Charles Matthew Jones

Theses and Dissertations

Modern Security Operations Centers (SOCs) ingest millions of log entries per day, but manual parsing does not scale to the volume, heterogeneity, and rapid evolution of log formats. This dissertation investigates whether unsupervised clustering can automate the generation of candidate field-extraction templates while remaining deployable in production and feasible under realistic runtime and memory constraints. The central research question asks whether a machine-learning-assisted pipeline that proposes extraction templates for security engineer review—relative to reproducible human-authored baselines such as hand-written regular expressions—can measurably improve rule-set deployability and corpus-scale extraction quality. Improvement is quantified using four applicability metrics: Coverage Rate (CR), Exclusive …

A Pedagogically Effective Conceptual Framework For The Resilience Of Unit Test Suites To Refactoring, Daniel Paul Knight

Theses and Dissertations

Unit test suites are intended to support safe and efficient source code refactoring, yet in practice they can hinder rather than help when tests are tightly coupled to implementation details. Such non-resilient tests require frequent co-evolution, consume valuable engineering time, and may disincentivize beneficial code improvements. While concepts such as passive and active resilience, test smells, and technical debt have been studied individually, they have not been integrated into a single actionable framework, nor has their pedagogical value been systematically evaluated. This dissertation introduces a novel conceptual framework for the resilience of unit test suites to refactoring, grounded in resilience …

Local And Indigenous Knowledge, Innovation, And Sustainable Development: Creating Sustainable Futures Amidst Crisis Conditions At The Community Level, Carlos Andrés Arias

Dissertations and Theses

In 1987, the Brundtland Commission's Our Common Future (1987) made clear the need to reject longstanding development processes and focus on sustainable development. The Commission stressed that actual sustainable development integrates three elements: social development, economic development, and environmental protection. Though developed nations have achieved economic growth through conventional and extractive development practices, these practices have intensified natural disasters driven by climate change, increased food insecurity, and deepened poverty. This has acutely impacted Indigenous and local communities, many of whom face crisis conditions, such as war, terrorism, civil disorder, and their aftermath. Even so, many of these communities successfully implement …

Optimal Control Of An Inverse Two-Point Boundary Value Problem For A Pseudoparabolic Equation With Samarskii–Ionkin-Type Boundary Conditions, Khanlar R. Mamedov, Tursun K. Yuldashev, Zholdoshbek Zh. Shermamatov

Turkish Journal of Mathematics

This paper investigates an inverse optimal control problem for a pseudoparabolic equation governed by nonlinear control function in a two-point boundary condition. The differential equation is considered under Samarskii Ionkin-type boundary value conditions with respect to the spatial variable x. Necessary optimality conditions are derived, and the associated nonlinear functional equations are analyzed. Using the contraction mapping principle, the existence and uniqueness of the control function are established. Subsequently, the redefinition function and the state function are determined. The convergence of their respective Fourier series representations is rigorously proven.

A Governance-Aware Multi-Agent Framework For Enhancing Fairness & Temporal Accuracy In Disaster Response Systems, Md. Ashfaqur Rahman

Theses and Dissertations

Large Language Models (LLMs) have demonstrated significant potential in disaster-response decision support, however, their deployment in high-stakes humanitarian settings raises critical concerns regarding factual reliability, fairness, temporal validity, and governance compliance. Hallucinated outputs, demographic bias, and outdated recommendations can directly impact vulnerable populations and undermine public trust. This dissertation proposes a governance-aware multi-agent framework designed to enhance fairness and temporal accuracy in disaster-response systems through structured Retrieval-Augmented Generation (RAG), verification-driven orchestration, and adaptive correction mechanisms.The proposed architecture decomposes response generation into specialized agents responsible for real-time retrieval, fact-checking, bias auditing, temporal validation, threshold-based correction, and monitoring. By embedding governance constraints …

Llms In Compiler Construction, Raffi Khatchadourian

Open Educational Resources

These lecture slides survey the use of large language models (LLMs) in compiler construction for a graduate compiler course (CSc 81010). They situate LLMs across the compiler pipeline and examine representative work: foundation models trained on LLVM IR and assembly (Meta's LLM Compiler), LLM-driven code optimization, binary decompilation (LLM4Decompile), and LLM-assisted automated refactoring—alongside the challenges of applying probabilistic models to tasks that demand correctness. The slides are a self-contained HTML (W3C Slidy) deck with editable Pandoc Markdown source. Part of a two-session unit on advanced compiler topics; see also "Deep Learning Compilers."