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Design And Implementation Of Error Estimators For Finite Element Eigenvalue Problems, Gabriel Esteban Pinochet Soto May 2026

Design And Implementation Of Error Estimators For Finite Element Eigenvalue Problems, Gabriel Esteban Pinochet Soto

Dissertations and Theses

We present three publications, all encompassed under the umbrella of a posteriori error estimation theory for eigenvalue problems for finite element discretizations. The central objective of the research is the development of a general framework for the study of reliable estimation of eigenvalues and eigenspaces. We introduce applications to problems of theoretical interest as well as problems arising in real-life scenarios, such as optical fibers. The first paper focuses on the implementation of a dual-weighted residual error estimator for a nonselfadjoint eigenvalue problems arising from the study of leaky modes in optical fibers---Maxwell's equations, Perfectly Matched Layers, and a conforming …


A Quantum Phase Space Description Of Local Noise In Atomic Ensembles, Andrew Kolmer Forbes May 2026

A Quantum Phase Space Description Of Local Noise In Atomic Ensembles, Andrew Kolmer Forbes

Physics & Astronomy ETDs

Nonclassicality in quantum sensors can improve sensitivity, but often increases susceptibility to noise. Thus, modeling physically relevant noise sources and analyzing their effect on quantum metrology are both of importance to the field of quantum sensing. In this dissertation, I demonstrate that local noise sources, which are present in almost all many-spin systems, can be tractably modeled when assuming permutation symmetry of the noise, and we show that many common local noise sources can be mapped to a Fokker-Planck equation on quantum phase space. We apply this description of noise to study quantum sensing using noisy probe states and establish …


Optical Nuclear Spin Detection In Diamond And Varifocal Metasurface Optics, Maxwell D. Aiello May 2026

Optical Nuclear Spin Detection In Diamond And Varifocal Metasurface Optics, Maxwell D. Aiello

Physics & Astronomy ETDs

This dissertation presents two experimental investigations at the intersection of quantum sensing and precision optical instrumentation. The primary project demonstrates optically detected nuclear magnetic resonance (NMR) of 13C nuclear spins in diamond, using state-selective Landau-Zener transitions under microwave frequency sweeping to bidirectionally transfer spin polarization between nitrogen-vacancy (NV) electron spins and remote 13C nuclear spins. This enables optical polarization and readout of large ensembles of polarized nuclear spins at low magnetic fields and room temperature, with spin dephasing times limited by longitudinal relaxation of nearby NV electron spins. The secondary project reports the design, fabrication, and characterization of …


Quantifying Co2 And Ch4 Fluxes In A Semi-Arid Floodplain: Assessing Spatial And Temporal Drivers, Miles E. Kelsey May 2026

Quantifying Co2 And Ch4 Fluxes In A Semi-Arid Floodplain: Assessing Spatial And Temporal Drivers, Miles E. Kelsey

Earth and Planetary Sciences ETDs

Rivers transport sediment and carbon across Earth’s surface, and their floodplains can store carbon over decades to millennia, making them important to terrestrial carbon management. While soil carbon can persist long term, it may be released as greenhouse gases through processes like methanogenesis and heterotrophic respiration. Environmental controls on these fluxes remain poorly constrained across floodplains in different climate and geomorphic setting, but especially in semi-arid systems where measurements are limited. To address this gap, we quantified CO₂ and CH₄ fluxes along the Middle Rio Grande (New Mexico, USA) using 227 chamber measurements collected May to November 2025 at three …


Continuous Polygenic Trait Evolution Under Brownian Motion With Gaussian Mixture Models, Mary S. Hopkins May 2026

Continuous Polygenic Trait Evolution Under Brownian Motion With Gaussian Mixture Models, Mary S. Hopkins

Mathematics & Statistics ETDs

Gaussian mixed-models (GMMs) show promise as a tool for modeling polygenic trait evolution for multiple taxa with established phylogenetic comparative methods (PCMs). When phenotypic traits are influenced by more than one gene, neither a gene tree nor a species tree may be completely adequate to model specific cross-taxa dependencies. In such cases common solutions include using trees inferred from concatenated DNA sequences [35, 95] and consensus gene trees [35]. The GMM-based model, first proposed by Jiang in 2017 [55] allows traits to evolve on more than one tree with distinct topologies. This approach provides a framework for trait evolutionary modeling …


Bayesian Designs For Two-Arm Clinical Trials With Time-To-Event Endpoints: Incorporating Historical Data Through Power Priors, Sara Hajraf H. Almutiri May 2026

Bayesian Designs For Two-Arm Clinical Trials With Time-To-Event Endpoints: Incorporating Historical Data Through Power Priors, Sara Hajraf H. Almutiri

Mathematics & Statistics ETDs

Bayesian methods provide a flexible framework for time-to-event analysis by incorporating prior information. The power prior offers a systematic way to borrow information from historical data. This approach is especially valuable in clinical research, where historical data can enhance inference in early-phase trials with limited sample sizes. This dissertation develops Bayesian approaches for two-arm survival studies using both closed-form and simulation-based methods. The closed-form inference is derived under exponential and Weibull survival models. Under the proportional hazards framework, the posterior is derived through a normal approximation to the log hazard ratio, allowing inference on the treatment effect when the variance …


Microtubules In Breast Cancer: Exploring The Α/Β-Tubulin Toggle Switch And Its Implications In Human Breast Cancer, Annemarie Ianos May 2026

Microtubules In Breast Cancer: Exploring The Α/Β-Tubulin Toggle Switch And Its Implications In Human Breast Cancer, Annemarie Ianos

Student Theses and Dissertations

Microtubules, composed of a/b-tubulin heterodimers, play a central role in breast cancer tumor growth by polymerizing, leading to metastasis and depolymerizing, contributing to proliferation. Human enzymes protein kinase Ca (PKC-a) and cyclin-dependent kinase 1 (Cdk-1) mediate phosphorylation at sites a:Ser165 and b:Ser172, respectively, influencing the growth of microtubules. It is possible that alternating phosphorylation at these sites contribute to an a/b-tubulin “toggle switch” that mediates microtubule instability and tumor growth.

The project investigates the influence of the toggle switch model on microtubule stability by determining the impact of mutants (a:S165D, a:S165N, a:S165SP, b:S172SP and a:S165SP/b:S172S …


Marine Geophysical Studies Of Coupled Tectonic And Sedimentary Processes At Active Plate Boundaries, Sarah R. Rysanek May 2026

Marine Geophysical Studies Of Coupled Tectonic And Sedimentary Processes At Active Plate Boundaries, Sarah R. Rysanek

Earth and Planetary Sciences ETDs

Deep-sea and convergent margin sedimentary systems preserve critical records of tectonic and climatic processes that shape Earth’s surface. This dissertation investigates source-to-sink sediment routing and forearc deformation to better constrain the interplay between sedimentary and tectonic processes, through investigations of a deep-sea fan system, and the forearc geomorphology offshore Nicaragua. In the Gulf of Alaska, we integrate ultra-long-offset and regional multi-channel seismic reflection data, multi-resolution bathymetry, and plate reconstructions to remap the Baranof Fan system. Results show that the fan is larger than previously recognized and constructed by two primary depocenters linked to distinct glacial sediment pathways, with accommodation space …


Constraining Magmatic Processes In The Central American Arc Using Melt Inclusion Vapor Bubble Analysis And Triple Oxygen Isotope Modeling And Exploration Of Volatile Contributions To The Production Of Continual Radio Frequency (Crf) Lightning Events, John M. Hamilton May 2026

Constraining Magmatic Processes In The Central American Arc Using Melt Inclusion Vapor Bubble Analysis And Triple Oxygen Isotope Modeling And Exploration Of Volatile Contributions To The Production Of Continual Radio Frequency (Crf) Lightning Events, John M. Hamilton

Earth and Planetary Sciences ETDs

Magmatic volatiles are key to determining the processes happening in the subsurface that we cannot directly sample. Advances in measuring volatile and isotope contents from erupted volcanic samples have given us the ability to understand magmatic processes, mixing components that produce the bulk magma composition and potentially precursors to eruptive hazards, such as lightning.

Through analysis of melt inclusions that sample the melt at depth and triple oxygen isotope quantification of olivine crystals from multiple volcanic edifices, the three following studies display how I have utilized these analytical techniques to help unravel processes happening in the subsurface that lead volcanic …


Computational Design Of Peptides And Proteins Through Machine Learning Approaches, Emily J. Hendrix May 2026

Computational Design Of Peptides And Proteins Through Machine Learning Approaches, Emily J. Hendrix

Chemistry and Chemical Biology ETDs

Advancements in machine learning have emerged as a pivotal tool in computational biochemistry, offering new advancements to address challenges in protein structure and function. However, current machine-learning approaches offer limited insight in understanding protein dynamics. The purpose of this work is to combine traditional physics-based computational tools, such as molecular dynamics and coarse-grained simulations, with recently developed AI-driven computational tools to bridge gaps and advance the understanding of proteins in both structural and dynamic aspects. I investigated several approaches such as (i) traditional physics-based methods to study protein conformation and ensembles; (ii) identifying a peptide inhibitor for the PICK1 PDZ …


Nanoscale Structure And Spontaneous Self-Assembly Of Hydrothermal Organic Products, Glorianne P. Dorce May 2026

Nanoscale Structure And Spontaneous Self-Assembly Of Hydrothermal Organic Products, Glorianne P. Dorce

Chemistry and Chemical Biology ETDs

Carbon nanomaterials derived from citric acid and urea exhibit behaviors that challenge conventional structure–property models based on static bulk descriptions. This study examines how precursor pairing and reaction duration, post‑synthetic thermal history, and time‑dependent aging govern nanoscale organization and optical response. Through controlled synthesis and processing, distinct nanostructures with tunable structural and spectroscopic profiles are generated.

A multiscale framework integrating nano‑FTIR, atomic force microscopy, and thermal analysis reveals chemical heterogeneity and continuous structural reorganization across length scales. By correlating local chemical environments with optical behavior, we show that fluorescence efficiency and photostability depend on specific nanoscale architectures rather than average …


Computing Certificates Of Members In Archimedean Quadratic Modules In A[X] And Certifying The Emptiness In Inconsistent Monogenic Archimedean Quadratic Modules In A[X_1, ..., X_N], Jose A. Castellanos Joo May 2026

Computing Certificates Of Members In Archimedean Quadratic Modules In A[X] And Certifying The Emptiness In Inconsistent Monogenic Archimedean Quadratic Modules In A[X_1, ..., X_N], Jose A. Castellanos Joo

Computer Science ETDs

Polynomials have been found to be a powerful tool over hundreds of years for modeling problems in numerous applications in science, engineering, medicine, and other domains. In the context of formal methods, polynomials arise in modeling in aerospace software and robotics, cyber-physical and hybrid systems, autonomous vehicles and controllers based on neural networks.

A quadratic module is a linear combination of polynomials in a set of generators (including the constant 1) with sum of squares polynomials as multipliers. The membership problem for a finitely generated quadratic module can be decided; however, computing a certificate exhibiting why it is nonnegative under …


Design, Fabrication, And Characterization Of Silicon Nitride Microresonator Optical Frequency Combs, Lala Rukh May 2026

Design, Fabrication, And Characterization Of Silicon Nitride Microresonator Optical Frequency Combs, Lala Rukh

Optical Science and Engineering ETDs

Optical frequency combs consist of equidistant optical frequencies and have numerous applications ranging from optical metrology to medical diagnostics. Initially, frequency combs were based on bulky mode-locked lasers, but advancements in integrated photonics enabled the generation of frequency combs in chip-scale resonators (microcombs) using Kerr nonlinearity. These miniaturized systems present various challenges, including increased propagation losses, enhanced thermal effects, and the extension of microcombs to visible wavelengths. In this dissertation, I will focus on addressing these challenges in silicon nitride (SiN) resonators. First, this thesis focuses on the fabrication of high-Q SiN resonators and the impact of fabrication parameters on …


Mapping Homogeneous Configuration States For Learning Based Motion Planners, Yazied Hasan May 2026

Mapping Homogeneous Configuration States For Learning Based Motion Planners, Yazied Hasan

Computer Science ETDs

Reinforcement learning (RL) excels at solving complex tasks, but training times can become prohibitively large for challenging motion-planning problems. Methods that address this cost often require additional training or tuning, counteracting the goal of reducing training time. A more effective approach is to exploit inherent task equivalences: many elements of the state space, dynamics, or structure are functionally interchangeable, enabling simplification or knowledge reuse. We present learning solutions that leverage these equivalences to enhance the RL process. First, we leverage the symmetry of homogeneous multi-agent teams to simplify the task to a single strategy. Second, we map correspondences between distinct …


From Sparse To Precise: Modeling Beam Profiles Using Wavelet-Based Implicit Neural Network (Winn) For Linear Accelerator Commissioning And Quality Assurance, Maryam Ali Albuainin May 2026

From Sparse To Precise: Modeling Beam Profiles Using Wavelet-Based Implicit Neural Network (Winn) For Linear Accelerator Commissioning And Quality Assurance, Maryam Ali Albuainin

Computer Science ETDs

Commissioning and routine quality assurance (QA) in radiotherapy require extensive measurements using bulky water tank systems, making the process time-consuming and costly. This research proposes an efficient framework for radiotherapy commissioning and QA by generating complete LINAC physics data from sparse measurements and developing a portable solid-water detector with embedded diodes for high-resolution dosimetry.

At the core of the framework is a Wavelet-based Implicit Neural Network (WINN) that reconstructs full measurement datasets from limited inputs while maintaining clinical accuracy. The model achieves gamma passing rates above 95% (1%/1 mm) and mean absolute errors below 0.5%, while reducing parameters by 99.46% …


Heavy Metal And Metalloid Accumulation In The Gallinas River Following The Hermit's Peak / Calf Canyon Wildfire, Olivia A. Kelly May 2026

Heavy Metal And Metalloid Accumulation In The Gallinas River Following The Hermit's Peak / Calf Canyon Wildfire, Olivia A. Kelly

Geography ETDs

This study evaluates the persistence and bioavailability of heavy metals and metalloids in the Gallinas River three years after the Hermit’s Peak/Calf Canyon Wildfire of 2022 using a multicompartment sampling framework that includes water, sediment, and benthic macroinvertebrate tissue analysis via inductively coupled plasma optical emission spectrometry (ICP-OES) and inductively coupled plasma mass spectrometry (ICP-MS). Results indicate that the Hermit’s Peak/Calf Canyon Fire continues to influence the hydrogeochemical condition of the Gallinas River. Sediments contain elevated concentrations of several metals and metalloids, and these same elements are detectable in macroinvertebrate tissues, linking sediment contamination to biological uptake. Zinc (Zn), silicon …


Realizing The Long Wavelength Array Swarm, Craig Anthony Taylor May 2026

Realizing The Long Wavelength Array Swarm, Craig Anthony Taylor

Physics & Astronomy ETDs

Sensitive modern radio interferometers are costly to build and operate at the university level. The `swarm telescope' concept addresses this challenge by enabling the collaborative use of individual telescope systems, overseen by separate institutions, that come together to form a more powerful and manageable facility. This dissertation focuses on demonstrating this concept using the Long Wavelength Array (LWA) by commissioning an aperture synthesis telescope consisting of interconnected LWA stations, called the LWA Swarm. The presented work details building a cost-efficient prototype LWA platform -- the LWA--North Arm station -- to enable synthesis imaging using the 3-element interferometer comprised of LWA1, …


A Multi-Frequency Investigation Of Compact Symmetric Objects, Evan E. Sheldahl May 2026

A Multi-Frequency Investigation Of Compact Symmetric Objects, Evan E. Sheldahl

Physics & Astronomy ETDs

Some of the brightest objects in the radio sky are jetted active galactic nuclei (AGN), supermassive black holes in the centers of galaxies that accelerate relativistic electrons into twin radio jets. One of the biggest questions surrounding AGN is how they produce radio jets in the first place. We search for an answer to this question by exploring a class of AGN that have uniquely well-constrained physical properties and are thought to be in an early stage of AGN development: compact symmetric objects (CSOs). Throughout our journey with these remarkable sources, we quantify their efficacy as calibrator sources for radio …


What Is The Skeleton Of Cognition? A Structural Account Of World Reconstruction Through Processing Axes, Griselda Poe May 2026

What Is The Skeleton Of Cognition? A Structural Account Of World Reconstruction Through Processing Axes, Griselda Poe

Publications and Research

This paper describes how the placement of a single processing axis reorganizes human cognition and generates a reconstructed world.

Most existing psychological and social theories begin from emotion, desire, morality, or social behavior. In doing so, they have discussed what forms on top of the cognitive skeleton without first fixing the skeleton itself. When the skeleton is not fixed, entirely different explanations of the same phenomenon can coexist, and it becomes difficult to identify which constitutes a foundational account.

This paper fixes the skeleton first. That skeleton is the processing axis.

The question is: when a single processing axis organizes …


Welcome Tilly Norwood: Forecasting Hollywood’S Ai Policy Futures, Samuel P. Rooker May 2026

Welcome Tilly Norwood: Forecasting Hollywood’S Ai Policy Futures, Samuel P. Rooker

Senior Honors Projects, 2020-current

In late 2025, weekly trade publication Variety Magazine reported on the announcement of a new acting talent in Hollywood: Tilly Norwood. Norwood is an industry outsider and the pet project of Eline Van der Velden, who unveiled the actress’ existence to the world at the Zurich Film Festival. The announcement quickly gained media coverage while Van der Velden has since faced cyclical backlash from Hollywood trade unions, which does not seem entirely without reason. Tilly Norwood is a digital persona, a generative artificial intelligence (GenAI) program, designed by Van der Velden’s novel AI talent studio, Xicoia, to become the next …


Saving The Great Basin: Creating Places For The Birds, Bees And Beyond, Carlos Gomez May 2026

Saving The Great Basin: Creating Places For The Birds, Bees And Beyond, Carlos Gomez

Hospitality Design Graduate Student Capstones

This project looks at how vacant and underused parcels along the Truckee River in Reno, Nevada, can be rethought as part of a larger ecological system. Rather than treating these parcels as empty leftover spaces, the project sees them as opportunities to create small habitat patches that can support native species, improve stormwater function, and strengthen the river corridor over time. The work focuses on three sites along the Truckee River: California Avenue, Island Avenue, and Commercial Row. Each site responds to a different condition along the urban transect, from a sloped residential river edge to a tighter urban parcel …


The Biowell System: An Integrative Framework That Connects Ecological Sustainability And Mental Wellbeing Through The Regenerative Processes Of Bioswales, Nathan A. Bussa May 2026

The Biowell System: An Integrative Framework That Connects Ecological Sustainability And Mental Wellbeing Through The Regenerative Processes Of Bioswales, Nathan A. Bussa

Hospitality Design Graduate Student Capstones

The Biowell System is an evaluative framework that connects ecological sustainability and mental well-being through the regenerative processes of bioswales.


Validation And Implementation Of Automated Planning Optimization In Utah Valley Hospital, Oluwatobi Adeniji May 2026

Validation And Implementation Of Automated Planning Optimization In Utah Valley Hospital, Oluwatobi Adeniji

UNLV Theses, Dissertations, Professional Papers, and Capstones

The increasing complexity of modern radiotherapy demands planning workflows that are efficient, standardized, and dosimetrically robust across diverse disease sites. Knowledge-based planning (KBP) systems such as RapidPlan offer a data-driven approach to automate and improve treatment planning by learning geometric–dosimetric relationships from high-quality clinical plans. In this work, I am evaluating the performance, generalizability, and clinical applicability of vendor-provided RapidPlan models across seven anatomical sites: intracranial SRS, prostate SBRT, right and left lung SBRT, liver SBRT, head and neck, and glioblastoma. Subsequently, a complementary institution-specific SRS model tailored to single-isocenter multitarget workflows was created. Seventy retrospectively selected patients were replanned …


Transboundary Groundwater Flow Between Niger And Nigeria In The Iullemeden Aquifer System, Gare Ambrose-Igho May 2026

Transboundary Groundwater Flow Between Niger And Nigeria In The Iullemeden Aquifer System, Gare Ambrose-Igho

UNLV Theses, Dissertations, Professional Papers, and Capstones

Groundwater is important in regions where water resources are not abundantly distributed such as arid and semi-arid regions. In many countries in Africa, groundwater serves as the most reliable source of water supply and supports over 50% of the African population. Groundwater is stored in underground water-bearing permeable rocks, rock fractures, or unconsolidated materials known as aquifers. Groundwater can be transboundary, meaning it crosses international political boundaries between two or more sovereign states. Transboundary aquifers are prone to overexploitation that depletes the groundwater resource and can cause a lowering of the water table and possible ground subsidence. Overexploitation in transboundary …


Unknowing Sacrifices: Public Health And Radiation Illness In New Mexico And Nevada, 1940s-1960s, Beatriz Avila-Marquez May 2026

Unknowing Sacrifices: Public Health And Radiation Illness In New Mexico And Nevada, 1940s-1960s, Beatriz Avila-Marquez

UNLV Theses, Dissertations, Professional Papers, and Capstones

The detonation of the first atomic bomb in the early morning of July 16, 1945, in New Mexico welcomed the atomic age that forever changed the world. After that day, thousands of lives were lost due to nuclear weapons, and hundreds of thousands more continued to suffer from the effects of atomic testing. The Atomic Energy Commission, fueled by the arms race of the Cold War, chose Nevada to continue the United States’ nuclear weapons testing. Knowledge of the dangers of radiation exposure, the effects of radiation, and techniques to prevent exposure are now available in part due to the …


Exploring Ai-Driven Scaffolding For Critical Questioning In Argument Evaluation, Ebenezer A. Belete May 2026

Exploring Ai-Driven Scaffolding For Critical Questioning In Argument Evaluation, Ebenezer A. Belete

UNLV Theses, Dissertations, Professional Papers, and Capstones

The fast-paced changes caused by generative AI (GenAI) innovations call for exploring the potential benefits of GenAI in empowering 21st-century pedagogical strategies. Previous studies in the field of argumentation have shown how students can benefit from using critical questions. However, scaffolding argument evaluation through custom GenAI using critical questions has not been systematically investigated. This study involved two components: (1) designing and determining the usability of a GPT-powered conversational assistant (CQMAA Conversational Assistant) and (2) testing its impact on participants' efficacy for argument evaluation and their acceptance of GenAI as a learning tool through a pretest–posttest experiment. A convergent mixed-methods …


“A Land No One Would Want”: Environmental Activism And The Rejection Of ‘Wasteland’ Narratives In Southern Nevada, Steven Butler May 2026

“A Land No One Would Want”: Environmental Activism And The Rejection Of ‘Wasteland’ Narratives In Southern Nevada, Steven Butler

UNLV Theses, Dissertations, Professional Papers, and Capstones

This paper traces events within the history of environmental activism in Southern Nevada. The first chapter discusses the proposed high level nuclear waste repository at Yucca Mountain. The second chapter examines the closure of the Reid Gardner Generating Station in Moapa, Nevada. The third chapter details the Southern Nevada Water Authority’s Groundwater Development Project. Each of the three chapters is linked by common themes within the history of Southern Nevada environmental activism, including dedicated coalition-building and the refusal of “wastelanding” of the region.


Relativistic Transients From Compact Objects: Radiation Processes And Geometric Effects, Connery Chen May 2026

Relativistic Transients From Compact Objects: Radiation Processes And Geometric Effects, Connery Chen

UNLV Theses, Dissertations, Professional Papers, and Capstones

Relativistic transients from compact objects probe the most extreme regimes of physics, where strong gravity, ultra-relativistic outflows, and high-energy radiation operate simultaneously; understanding the underlying radiation mechanisms and extrinsic geometric and relativistic effects is essential for interpreting observations and constraining source properties. I develop theoretical and computational frameworks to quantify how geometry and relativistic motion shape observed emission from fast radio bursts, gamma-ray bursts, and neutron star mergers. I analyze fast radio bursts from the Galactic magnetar SGR J1935+2154 and show that emission geometry strongly governs burst energetics and detection probability, and influences the link between radio and X-ray emission. …


The Yorp Effect In Reboundx, Kaelyn Clement May 2026

The Yorp Effect In Reboundx, Kaelyn Clement

UNLV Theses, Dissertations, Professional Papers, and Capstones

The Yarkovsky-O’Keefe-Radzievskii-Paddack (YORP) effect is a radiation-induced torque that can affect the spin and rotational obliquity of small bodies. It has been observed to alter the rotation rate of asteroids in the Solar System (Lowry et al. 2007; Taylor et al. 2007). Under extreme circumstances, YORP can cause a body to fragment, inducing a cascade of fissions. This effect may be important in driving the pollution of white dwarf atmospheres in conjunction with other radiative forces. I developed a YORP calculator for REBOUNDX (Tamayo et al. 2020), an extensional library to the N-body integrator REBOUND (Rein & Liu 2012). I …


Interpretable Deep Learning Models For Trustworthy Prediction Of Enzyme Functions, Louis Dumontet May 2026

Interpretable Deep Learning Models For Trustworthy Prediction Of Enzyme Functions, Louis Dumontet

UNLV Theses, Dissertations, Professional Papers, and Capstones

Trustworthy prediction of enzyme function from protein sequences remains a central challenge in computational biology, particularly when annotated data are limited, imbalanced, or incomplete. This dissertation develops interpretable deep learning methods for enzyme discovery and enzyme function prediction from amino acid sequences. First, it introduces PEPIC, an interpretable convolutional neural network for substrate-level prediction of hydrolytic plastic-degrading enzymes. Using curated and expanded sequence datasets, PEPIC improved predictive performance over benchmark methods, identified sequence regions aligned with catalytic and substrate-binding residues, and supported the discovery and experimental validation of a previously uncharacterized PET-degrading enzyme. Second, this dissertation investigates the integration of …