Digital Commons Network^™

A Copper-Selective Sensor And Its Inhibition Of Copper-Amyloid Beta Aggregation, Ngoc Kim Nguyen, Bella Poduska, Mia Franks, Manoranjan Bera, Ian Maccormack, Guoxing Lin, Alexander P. Petroff, Samir Das, Arundhati Nag

Chemistry

Copper is an essential trace metal for biological processes in humans and animals. A low level of copper detection at physiological pH using fluorescent probes is very important for in vitro applications, such as the detection of copper in water or urine, and in vivo applications, such as tracking the dynamic copper concentrations inside cells. Copper homeostasis is disrupted in neurological diseases like Alzheimer’s disease, and copper forms aggregates with amyloid beta (Ab42) peptide, resulting in senile plaques in Alzheimer’s brains. Therefore, a selective copper detector probe that can detect amyloid beta peptide-copper aggregates and decrease the aggregate size has …

Relationship Between Marine Heatwaves And Diadema Antillarum Settlement In The Florida Keys, David Ogando Jr.

Theses, Dissertations and Culminating Projects

Ocean warming can have profound impacts on benthic marine invertebrates through direct physiological effects. Yet, the impacts of ocean warming on the long-spined sea urchin (Diadema antillarum), a keystone grazer on western Atlantic and Caribbean coral reefs, has received little attention. In the summer of 2023, the Caribbean basin experienced a strong marine heatwave event with sea temperatures ~1–3°C above average and the warmest on record in southern Florida. An ongoing field settlement sampling program for D. antillarum in the Florida Keys provided an opportunity to examine the correlative relationship between thermal exposure and larval settlement. Thermal exposure was quantified …

The Influence Of Edaphic Factors On The Growth And Competitiveness Of Loosestrife (Lythrum Spp.), Martha Mahady

Theses, Dissertations and Culminating Projects

Wetlands are important areas in the landscape, providing important ecosystem services. Purple loosestrife (Lythrum salicaria), native to Europe and Asia, invades wetlands in North America, outcompeting native wetland plants and disrupting ecosystem services. While purple loosestrife is invasive in North America, it is not in its native range. Winged loosestrife (Lythrum alatum), a North American native congener, is not invasive in North America. Purple loosestrife from Sussex County, N.J. U.S.A. and purple loosestrife from the United Kingdom, and winged loosestrife were compared in this study. Their response to soil edaphic factors, such as seed vernalization, soil nutrients, soil pH, water, …

A Global Analysis Of Carbon And Nitrogen Stocks In Natural And Anthropogenic Soils, Shih-Chieh Chien

Theses, Dissertations and Culminating Projects

In terrestrial biomes, soils possess the highest amount of carbon and nitrogen stocks that regulate biogeochemical processes and provide ecosystem services. The amount of carbon and nitrogen stored in soils, as a balance of nutrient influxes and outfluxes, is controlled by various environmental and soil factors, while at the same time soil carbon and nitrogen stocks can be subject to anthropogenic impacts, like nutrient storage in urban soils. To inform a better, general understanding of carbon and nitrogen distribution in urban soils, the present dissertation gathers four articles (from Chapters 2 to 5, respectively) addressing different aspects of the issue, …

Evaluation Of Heavy Metal Pollution, Water Quality, And The Effectiveness Of Remedial Sediment Dredging In The Lower Passaic River, New Jersey, Oluwafemi Soetan

Theses, Dissertations and Culminating Projects

Toxic metal pollution is a leading environmental concern for aquatic systems globally and remedial dredging has been widely employed to mitigate its harmful impacts. In terms of the short-term impacts of remedial dredging, mixed results are reported in several studies. Despite its immediate negative impacts including saturation of water with toxic metals, increased turbidity, and sediment resuspension, positive impacts can be recorded over a stabilization period of 6 – 24 months after dredging. Nevertheless, the sustainability of these recorded positive effects cannot be ascertained as some studies have reported long-term regression in remediated sites’ conditions. Evaluation of success determinants, site-measure …

Determining The Time Since Deposition Of Bloodstains Based On Vibrational Spectroscopy For Forensic Purposes, Alexis Renee Weber

Legacy Theses & Dissertations (2009 - 2024)

At the scene of violent crimes, bloodstain evidence is one of the most frequently found and valuable types of evidence. Blood traces discovered at crime scenes can provide crucial information to an investigation. By obtaining a DNA profile from the bloodstain, the profile can be used to link someone to a crime scene, which can corroborate or dispute a witness's statement. However, the current analysis of bloodstains is still not able to answer a key question for investigators: how much time has passed since the criminal event occurred? In addition, an equally important aspect of crime reconstruction is the ability …

Advancing Learning Models For High-Dimensional Data: From Molecular Modeling To Motion Planning, Tuan Nguyen Anh Tran

Legacy Theses & Dissertations (2009 - 2024)

Processing and analyzing high-dimensional data, particularly in domains like protein research and robotics, introduces unique challenges. In protein analysis, high-dimensional data often arises from complex molecular structures and their interactions. Analyzing protein data involves intricate computational models and algorithms that must deal with the large size of molecular datasets and the need to extract biologically relevant information. This makes it challenging to discern significant protein structure-activity relationships, understand complex biological interactions, or predict protein behavior accurately. Similarly, in robotics, high-dimensional data is prevalent when dealing with sensory inputs, the dimensionality of the robot, or the complexity of the operational environments. …

Screening Full-Sib And Half-Sib Families Of Chestnut Seedlings For Resistance To Cryphonectria Parasitica Using A Small Stem Assay And A Leaf-Disc Assay, Uma Plambeck

Honors Theses

Cryphonectria parasitica is the ascomycete fungus species that causes chestnut blight disease. Symptoms of chestnut blight include bark cankers and eventually the death of American chestnut, Castanea dentata. However, not all Castanea species are equally affected by the disease, and some Asian species appear highly resistant. The OALDS and SSA in this study aim to assist in screening for resistance to C. parasitica within a year. We investigated the effect of C. parasitica on three North American species, one European species, four East Asian species of Castanea, and nine full-sib families of TACF backcross hybrids. Our study used both a …

The Effect Of Agrivoltaics On Irrigation Water Consumption In Central California, London Camba

Undergraduate Theses

An agricultural system where solar energy generation and agricultural systems are used together for mutual benefit, agrivoltaics reduces loss of water due to evaporation, particularly in drylands. Central California has faced extreme droughts, and water has become a scarce resource. However, the wide-scale use of agrivoltaics has been limited due to lack of knowledge about agrivoltaics and also the lack of funding for start-up agrivoltaics projects. Therefore, this research investigated the potential for agrivoltaics in Central California to reduce irrigation water consumption using a review of multiple crop studies using agrivoltaics to determine an optimal crop for agrivoltaics and a …

Combining Temperature-Dependent Life Table Data Into Insect Life Cycle Model To Forecast Fall Armyworm Spodoptera Frugiperda (Je Smith) Distribution In Maize Agro-Ecological Zones In Africa, Marian Adan, Henri E.Z. Tonnang, Cojdo E.F. Kassa, Klaus Greve, Christian Borgemeister, Georg Goergen

All Peer-Reviewed Publications

The fall armyworm (FAW), Spodoptera frugiperda (JE Smith) (Lepidoptera: Noctuidae), an invasive agricultural pest, has significantly impacted crop yields across Africa. This study investigated the relationship between temperature and FAW life history traits, employing life cycle modeling at temperatures of 20, 25, 28, 30, and 32̊C. The development time for eggs, larvae, and pupae varied from 0–3 days, 10–18 days, and 7–16 days, respectively. The optimal temperature range for immature stage survival and female fecundity was identified as 21–25̊C, with the intrinsic rate of increase (rm) and gross reproductive rate (GRR) peaking at 25–28̊C. Model validation confirmed the accuracy of …

Assessing Equitable Distribution Of The Urban Tree Canopy At The Neighborhood Scale In Greenville, South Carolina., April Riehm

All Theses

We are living in an era that necessitates adaptation and resilience. The Earth is warming. Our climate has changed (EPA, 2016). Our planet is also rapidly urbanizing. It is predicted that 68% of people will live in cities by 2050. The City of Greenville is a rapidly growing city in South Carolina that has been losing its tree canopy to development(City of Greenville, 2023). The Urban Tree Canopy (UTC) is a community asset that provides many quality-of-life benefits including improved air quality, stormwater management, carbon sequestration, mental and physical well-being, increased mobility and access, aesthetics, a reduction in energy costs, …

Navigating Real-World Challenges: A Quadruped Robot Guiding System For Visually Impaired People In Diverse Environments, Shaojun Cai, Ashwin Ram, Zhengtai Gou, Mohd Alqama Wasim Shaikh, Yu-An Chen, Yingjia Wan, Kotaro Hara, Shengdong Zhao, David Hsu

Research Collection School Of Computing and Information Systems

Blind and Visually Impaired (BVI) people find challenges in navigating unfamiliar environments, even using assistive tools such as white canes or smart devices. Increasingly affordable quadruped robots offer us opportunities to design autonomous guides that could improve how BVI people find ways around unfamiliar environments and maneuver therein. In this work, we designed RDog, a quadruped robot guiding system that supports BVI individuals’ navigation and obstacle avoidance in indoor and outdoor environments. RDog combines an advanced mapping and navigation system to guide users with force feedback and preemptive voice feedback. Using this robot as an evaluation apparatus, we conducted experiments …

A Revised Synthesis Of The Cationic Lipids Dmri And Mlri, Benjamin A. Kostic

College of Arts & Sciences Senior Theses

Lipid nanoparticles (LNPs) are an increasingly utilized method of intracellular delivery for nucleic acids. The COVID-19 vaccines from Moderna and Pfizer-BioNTech have used LNP technology to combat the recent global SARS-CoV-2 pandemic, saving millions of lives.^1,2 These vaccines consist of a lipid formulation that binds to the anionic phosphate groups of mRNAs and serves as an effective way to transport the nucleic acid across membranes into cells.⁹The mRNA encodes a viral protein. When introduced to cells, the viral protein is produced so that the immune system then can generate an appropriate antibody response.³ However, this approach …

The Pawn System: How Procedurally Adaptive Webbed Narratives Create Stories, Steven T. Bordelon

LSU New Orleans Theses and Dissertations

This thesis describes the design, implementation, and testing of a novel procedural narrative system called the Procedurally Adaptive Webbed Narrative (PAWN) system. PAWN procedurally generates characters and, responding to choices made by the player, produces more responsive characters and relationships involving the player and these narrative agents. Initially, this thesis discusses other interactive narrative types that exist, such as emergent or event-driven narratives, along with their strengths and weaknesses. It then examines each aspect of PAWN, starting with initial actor generation, then moving to the capturing of game events and translating them into logical objects called Occurrences. These Occurrences are …

The Water That Will Be: A Qualitative Look Into The Effects Of Visual Imagery On Participation In Water Conservation Initiatives, Shane Martin White

Graduate Theses and Dissertations

This dissertation explored the role of visual imagery in water conservation initiatives, focusing on its impact on public understanding, emotional connection, and willingness to participate. Drawing from the Theory of Planned Behavior and Affective Disposition Theory, the study investigated how art interventions can enhance comprehension and engagement with water conservation easements. Utilizing qualitative methods, including interviews, focus groups and PhotoVoice, data was collected from stakeholders in the Illinois River Watershed region. The research examined current levels of understanding regarding conservation easements, evaluated the effectiveness of visual imagery interventions in enhancing public awareness, and identified the potential for collaborative approaches between …

5-Year Strategic Direction, 2024–2028: Institute Of Agriculture And Natural Resources, University Of Nebraska–Lincoln, Institute Of Agriculture And Natural Resources University Of Nebraska-Lincoln

Institute of Agriculture and Natural Resources: Institute Publications

IANR: Integrating Learning, Discovery, and Engagement for an Even Better Nebraska

Includes an introduction, description of the components of the Institute of Agriculture and Natural Resources at the University of Nebraska–Lincoln, the IANR pillars, stratgeic aims for 2024–2028, and a section on implementation.

Coastal-Ocean And Estuarine Acidification In Long Bay, South Carolina: A Comparison Of In-Situ Water Quality Monitoring With Measured Carbonate System Parameters, Mary Olsen

Electronic Theses and Dissertations

One of the major water-quality issues impacting our coast and estuaries is coastal-ocean and estuarine acidification. Due to a relative dearth of data in the southeastern United States it is increasingly difficult to determine the full extent and intensity of this problem. This study provides the first characterization of coastal-ocean and estuarine acidification in Long Bay, SC by attempting to leverage long-term water quality data sets at two coastal-ocean pier sites using in-situ YSI EXO sondes deployed at both the surface and bottom waters along with two estuarine sites sampled by volunteer monitors using Orion star multi-meters. Discrete samples (120) …

Next-Generation Crop Monitoring Technologies: Case Studies About Edge Image Processing For Crop Monitoring And Soil Water Property Modeling Via Above-Ground Sensors, Nipuna Chamara

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Artificial Intelligence (AI) has advanced rapidly in the past two decades. Internet of Things (IoT) technology has advanced rapidly during the last decade. Merging these two technologies has immense potential in several industries, including agriculture.

We have identified several research gaps in utilizing IoT technology in agriculture. One problem was the digital divide between rural, unconnected, or limited connected areas and urban areas for utilizing images for decision-making, which has advanced with the growth of AI. Another area for improvement was the farmers' demotivation to use in-situ soil moisture sensors for irrigation decision-making due to inherited installation difficulties. As Nebraska …

Automated Cinematographer For Vr Viewing Experiences, Zihan Wu

Dartmouth College Master’s Theses

As the virtual reality (VR) industry continues to evolve, the question of how to effectively capture VR experiences for an audience remains a challenge. The predominant method of showcasing VR applications through first-person recordings lacks cinematic interest, failing to capture other viewpoints and the essence of the moment. Meanwhile, manually setting up cameras and editing videos requires technical expertise on behalf of the user. In this paper, we propose the use of machine learning (ML) to automatically select the most compelling predefined viewpoint in a VR environment, at any given moment. Our models, trained on actor motion and voice volume, …

Do Heat Waves Drive Natural Selection In Damselflies?, Adam Baranyk

Biological Sciences Undergraduate Honors Theses

Climate change has led to changes in both mean temperatures and temperature extremes over the recent years. These changes have had differential effects on animals throughout the world. Ectotherms depend on their external environment for thermal regulation, making them especially susceptible to temperature extremes. It is not yet clear whether there is a relationship between physical traits in ectotherms, and survivorship throughout a heat wave. That is, whether or not temperature extremes driven survival selection. In this study, a heat wave was simulated artificially using thermally regulated mesocosms at different temperatures (18°C, 22° C, 26° C, 30° C) with a …

Affinity-Enhanced Microdialysis Using Covalent Organic Frameworks (Cofs) Applied To Various Non-Steroidal Anti-Inflammatory Drugs (Nsaids) And Their Metabolites, Kehinde Adedeji Olubanjo

Graduate Theses and Dissertations

Microdialysis is a valuable tool in neurosciences and pharmaceutical sciences, aiding research in drug-related areas. However, it faces a notable limitation in sampling hydrophobic analytes due to their adherence to the probe materials brought about by non-specific adsorption, thereby reducing relative recovery or overall extraction. In this work, two affinity agents, polydimethylsiloxane (PDMS) beads suspended in sodium dodecyl sulfate (SDS) surfactant and covalent organic frameworks I(COFs) were employed as affinity agents in microdialysis for the extraction of hydrophobic drugs. When PDMS beads were employed as affinity agents, at the flow rate of 1 µL/min the relative recovery of both the …

Statistical Classification Using Selection And Ranking Methodologies With Statistical Learning, Jeong Jun Lee

UNLV Theses, Dissertations, Professional Papers, and Capstones

The subject of Statistical Classification is concerned with identifying and allocating future observations into one of the pre-categorized classes based on the characteristics of the objects. Typically, these decisions to classify and categorize the objects have been dependent on identifying a system of classification, and from there, determining attributes for sorting.

In past decades, from discriminant analysis, various methods have been developed for classification. In particular, the rise of artificial intelligence (AI), machine learning, and statistical learning theory has made it possible to consider improving the existing methods along with new developments and more comprehensive schemes in conjunction with data-driven …

Plant-Plant Interaction In Early- Vs. Late-Successional Varieties Of The Hawaiian Landscape-Dominant Tree, Metrosideros Polymorpha, Tomoko Sakishima

UNLV Theses, Dissertations, Professional Papers, and Capstones

Plant-plant interactions play an important role in assembling plant communities. Interactions between neighboring plants can vary as a result of the genetic relatedness of neighbors, impacting rates of growth and patterns of resource allocation. When growing alongside close relatives, some species decrease their growth in a form of cooperation, while others grow faster through facilitation. A complication of plant interaction studies arises because decreased growth in the presence of close relatives can also be due to competition for resources, which increases with phenotypic similarity. Further complicating matters, mycorrhizal fungi, through their connections with plant roots, may strongly influence plant interactions. …

Bacteria Synergized With Pd-1 Blockade Enhance Positive Feedback Loop Of Cancer Cells-M1 Macrophages-T Cells In Glioma, Qi Chen, Yuyi Zheng, Xiaojie Chen, Yuan Xing, Jiajie Zhang, Xinyi Yan, Qi Zhang, Di Wu, Zhong Chen

Faculty, Staff and Student Publications

Cancer immunotherapy is an attractive strategy because it stimulates immune cells to target malignant cells by regulating the intrinsic activity of the immune system. However, due to lacking many immunologic markers, it remains difficult to treat glioma, a representative "cold" tumor. Herein, to wake the "hot" tumor immunity of glioma, Porphyromonas gingivalis (Pg) is customized with a coating to create an immunogenic tumor microenvironment and further prove the effect in combination with the immune checkpoint agent anti-PD-1, exhibiting elevated therapeutic efficacy. This is accomplished not by enhancing the delivery of PD-1 blockade to enhance the effect of immunotherapy, but by …

Life On The Edge: The Cambrian Marine Realm And Oxygenation, Sara Pruss, Benjamin C. Gill

Geosciences: Faculty Publications

The beginning of the Phanerozoic saw two biological events that set the stage for all life that was to come: (a) the Cambrian Explosion (the appearance of most marine invertebrate phyla) and (b) the Great Ordovician Biodiversification Event (GOBE), the subsequent substantial accumulation of marine biodiversity. Here, we examine the current state of understanding of marine environments and ecosystems from the late Ediacaran through the Early Ordovician, which spans this biologically important interval. Through a compilation and review of the existing geochemical, mineralogical, sedimentological, and fossil records, we argue that this interval was one of sustained low and variable marine …

Evaluating Novel Approaches For Improving Anadromous Fish Passage In Coastal Rivers, Aaron Bunch

All Dissertations

Few of the world's rivers remain free-flowing for over 1000 km, significantly impacting anadromous fish populations due to dam-induced habitat fragmentation. Three partial migration barriers (low-head dams) on North Carolina's Cape Fear River (USA)—lock and dam 1 (LD1), lock and dam 2 (LD2), and lock and dam 3 (LD3)—impact American shad Alosa sapidissima, Atlantic sturgeon Acipenser oxyrinchus oxyrinchus, and striped bass Morone saxatilis populations. Mitigation strategies to pass fish upstream have included conservation locking, nature-like fishway construction, and environmental flows (e-flows). This study introduced a novel e-flow (dam submergence flow), tested acoustic double-tagging techniques for tracking American …

Patterns In Macrofaunal Abundance And Biodiversity At Sites In The Florida Keys, Cydney Wolff

Theses, Dissertations and Culminating Projects

Coral reef health in the Florida Keys, USA has been declining in recent years. To gain an understanding of the current state of macrofaunal abundance and biodiversity on these reefs, research was conducted to identify and count the macrofauna colonizing standardized settlement plates at two coral reef sites, one in the middle (Delta Shoal) and one in the lower (Pelican Shoal) Florida Keys. Plates were deployed for a one-month period in June 2023. At each site, the plates were placed at two heights: ocean bottom and 2 m above ocean bottom (two plates per height per site for a total …

Vr Circuit Simulation With Advanced Visualization For Enhancing Comprehension In Electrical Engineering, Elliott Wolbach

Department of Electrical and Computer Engineering: Dissertations, Theses, and Student Research

As technology advances, the field of electrical and computer engineering continuously demands innovative tools and methodologies to facilitate effective learning and comprehension of fundamental concepts. Through a comprehensive literature review, it was discovered that there was a gap in the current research on using VR technology to effectively visualize and comprehend non-observable electrical characteristics of electronic circuits. This thesis explores the integration of Virtual Reality (VR) technology and real-time electronic circuit simulation with enhanced visualization of non-observable concepts such as voltage distribution and current flow within these circuits. The primary objective is to develop an immersive educational platform that makes …

The Effects Of Using Machine Translators On The Performance Of Second Language Learners, Kasey Myer

University Honors College

With the rise of technology has also come the development of various online language translators and artificial intelligence that are often utilized by individuals learning a second language. However, there is a wide range of quality between the different machine translation tools, and many people tend to be under the impression that it is inferior to the quality of interpretations provided by human translators. This paper considers the positives and negatives of machine translation as a tool for second language learning. Variations between the input and output languages on a grammatical and cultural level are analyzed. Machine translation is compared …

Ecological Dynamics Of Cenozoic North American Mammals, Alexandria Brandis Shupinski

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Understanding how community structure is affected by various ecological, climatic, and environmental changes is a long-standing goal in ecology. However, disentangling human impacts from these other variables is difficult when using short modern timescales and anthropogenically altered communities. The fossil record provides a means to investigate community structure dynamics across critical intervals, excluding humans as a variable. Here, in three studies, I assess changes in North American mammal paleocommunity structure across the last 66 million years (Ma) at multiple temporal and spatial scales. In Chapter 1, I identify changes in mammal functional diversity (FD) locally and continentally, using three independent …