Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Mental and Social Health

Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 1351 - 1380 of 10284

Full-Text Articles in Entire DC Network

Self-Identifying Minoritized Doctoral Students’ Experiences Of Epistemic Injustice In Counselor Education And Supervision, Francisca Rivas Oct 2024

Self-Identifying Minoritized Doctoral Students’ Experiences Of Epistemic Injustice In Counselor Education And Supervision, Francisca Rivas

Counseling & Human Services Theses & Dissertations

The purpose of this qualitative study was to examine and understand how epistemic injustice (EI) is experienced by minoritized doctoral students in Counselor Education and Supervision programs. The primary researcher performed a phenomenological study examining the experiences of EI for minoritized CES students (n = 8). There were three female participants with an average age of 31, two male participants with an average age of 31, and three nonbinary/trans participants with the average age of 33. Five participants were BIPOC, one being an international student, and six participants were LGBTQPA+. Five participants held Ph.Ds. at time of their interview, having …


Increasing The Frequency Of Behavior Assessment To Reduce Physical Restraint, Breanne N. Ford Sep 2024

Increasing The Frequency Of Behavior Assessment To Reduce Physical Restraint, Breanne N. Ford

Doctor of Nursing Practice Final Project Abstract

Purpose: The purpose of this quality improvement (QI) project was to implement a system that routinely assesses for behavior changes in psychiatric patients presenting to the emergency department to improve staff intervention of escalating behaviors and decrease physical restraint use.

Background: The project was implemented in a 45-bed emergency department in a community-based hospital affiliated with a large hospital system in Houston, Texas.

Methodology: The project utilizes the Behavioral Activity Rating Scale (BARS) to assess patients' behaviors at routine intervals throughout shifts and a comfort cart that houses several non-pharmacological intervention items to use to de-escalate adverse behaviors. The staff …


Use Of The Integrated Practice Assessment Tool (Ipat) To Evaluate The Clinical Learning Environment For Counselors-In-Training, Jessica Lloyd-Hazlett, Stacy Ogbeide, Heather Trepal, Mercedes Ingram, Swathi Weaver Sep 2024

Use Of The Integrated Practice Assessment Tool (Ipat) To Evaluate The Clinical Learning Environment For Counselors-In-Training, Jessica Lloyd-Hazlett, Stacy Ogbeide, Heather Trepal, Mercedes Ingram, Swathi Weaver

Journal of Human Services Scholarship and Interprofessional Collaboration

The need for behavioral health integration (BHI) in primary care continues to grow to address the behavioral health needs of patients and families. Developing a competent interprofessional workforce to operate in primary care behavioral health settings necessitates BHI-literate clinical learning environments, as well as tools to evaluate and assist in the integration of services appropriate for BHI training and supervision. The Integrated Practice Assessment Tool (IPAT; Waxmonsky et al., 2014) is an instrument that assesses the level of BHI at a primary care clinic. This paper discusses an example of an implementation approach to examine BHI levels with the IPAT …


Addressing Adolescent Suicide In South Korea, Alyssa Kang Sep 2024

Addressing Adolescent Suicide In South Korea, Alyssa Kang

Journal of Nonprofit Innovation

Suicide is a prevalent issue that widely affects all demographics in South Korea. Among adolescents, it is the leading cause of mortality with an average rate of 7 deaths per 100,000 people. Some of the most significant factors that influence the risk of suicidal ideation and attempts are cultural stigma and academic stress. Other factors, such as bullying and family structure, also increase the likelihood of suicide, while specific characteristics including internet addiction, socioeconomic status, and substance abuse have been found to be predictors of suicide. Adolescent suicide attempts in Korea also increase the individual's risk for future attempts, and …


Emotional Display Rules Of Deaf Culture, Nicholas M. Gala, Lawrence Pick Sep 2024

Emotional Display Rules Of Deaf Culture, Nicholas M. Gala, Lawrence Pick

JADARA

Emotional display rules refer to the expression of culturally prescribed and socially acceptable emotions across different people and situations (Wu & Schulz, 2020). The display rules among hearing adults across several cultures are well defined and depend on the type of emotion, the individuals involved in the exchange, and the situation. Regarding Deaf culture in the United States, this minoritized group may follow unique display rules (Hosie et al., 2000), but there has been almost no research conducted with this population and the existing studies have focused on youth. The present study explores perceived emotional expressions among a sample of …


A Brief Review Of Zuranolone, Aubrey A. Jackson Sep 2024

A Brief Review Of Zuranolone, Aubrey A. Jackson

Transformative Medicine

Zuranolone, a novel analog of allopregnanolone, has been approved by the U.S. Food and Drug Administration (FDA) as the first oral medication approved for the treatment of postpartum depression in adults. Developed by Sage Therapeutics under the brand name Zurzuvae, zuranolone was approved by the FDA on August 4th, 2023.1 Zuranolone is a modified version of brexanolone (sold under the brand name Zulpresso), an intravenously administered allopregnanolone formulation that was previously the only FDA-approved medication for postpartum depression. Zuranolone offers a more accessible treatment option for patients with efficacy established in clinical trials. Its approval expands the …


Skin In The Game: A Review Of Single-Cell And Spatial Transcriptomics In Dermatological Research, Samuel Schepps, Jonathan Xu, Henry Yang, Jenna Mandel, Jaanvi Mehta, Julianna Tolotta, Nicole Baker, Volkan Tekmen, Neda Nikbakht, Paolo Fortina, Ignacia Fuentes, Bonnie Lafleur, Raymond J Cho, Andrew P South Sep 2024

Skin In The Game: A Review Of Single-Cell And Spatial Transcriptomics In Dermatological Research, Samuel Schepps, Jonathan Xu, Henry Yang, Jenna Mandel, Jaanvi Mehta, Julianna Tolotta, Nicole Baker, Volkan Tekmen, Neda Nikbakht, Paolo Fortina, Ignacia Fuentes, Bonnie Lafleur, Raymond J Cho, Andrew P South

Staff and Researcher Publications

Single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) are two emerging research technologies that uniquely characterize gene expression microenvironments on a cellular or subcellular level. The skin, a clinically accessible tissue composed of diverse, essential cell populations, serves as an ideal target for these high-resolution investigative approaches. Using these tools, researchers are assembling a compendium of data and discoveries in healthy skin as well as a range of dermatologic pathophysiologies, including atopic dermatitis, psoriasis, and cutaneous malignancies. The ongoing advancement of single-cell approaches, coupled with anticipated decreases in cost with increased adoption, will reshape dermatologic research, profoundly influencing disease characterization, …


Codesigning A Clinical Prediction Model For Aboriginal Perinatal Mental Health Using Glassbox Ai And Aboriginal Wisdom And Lived Experience, Guanjin Wang, Hachem Bennamoun, Wai Hang Kwok, Rhonda Marriott, Roz Walker, Jayne Kotz Sep 2024

Codesigning A Clinical Prediction Model For Aboriginal Perinatal Mental Health Using Glassbox Ai And Aboriginal Wisdom And Lived Experience, Guanjin Wang, Hachem Bennamoun, Wai Hang Kwok, Rhonda Marriott, Roz Walker, Jayne Kotz

Research outputs 2022 to 2026

Perinatal mental health is vital for mothers, infants, and families. Aboriginal mothers, despite their strengths, face greater mental health disparities due to colonisation and trauma. Traditional screening methods lack cultural sensitivity. The Baby Coming You Ready (BCYR) program offers a culturally sensitive assessment with promising pilot results. To support health professionals, an AI solution using the Explainable Boosting Machine (EBM) is proposed, trained with Aboriginal lived experiences. This model identifies maternal protective and risk factors, offering interpretable predictions for holistic culturally sensitive care.


The Presence Of A Pet Dog Is Associated With A More Balanced Response To A Social Stressor, Jaci Gandenberger, Aurélie Ledreux, Ashley Taeckens, Kerry Murphy, Jenni Forkin, Anah Gilmore, Kevin N. Morris Sep 2024

The Presence Of A Pet Dog Is Associated With A More Balanced Response To A Social Stressor, Jaci Gandenberger, Aurélie Ledreux, Ashley Taeckens, Kerry Murphy, Jenni Forkin, Anah Gilmore, Kevin N. Morris

Institute for Human-Animal Connection: Faculty Scholarship

Acute and chronic stress each have physical manifestations in the human body that can lead to many negative health impacts. Today, reported stress levels worldwide are at an all-time high, spurring the search for non-pharmaceutical interventions to maintain healthy stress levels. In this study, we examined whether a pet dog’s presence influences healthy adults’ acute stress responses as assessed through self-reports, heart rate, plasma cortisol, and salivary alpha-amylase. Participating pet dog owners were randomly assigned to undergo the Trier Social Stress Test either with their pet dog or alone. While there was no group difference in perceived anxiety levels, participants …


Providing End-Of-Life Counseling: A Narrative Inquiry, Carol Hecht, Sibyl West Sep 2024

Providing End-Of-Life Counseling: A Narrative Inquiry, Carol Hecht, Sibyl West

Adultspan Journal

This qualitative study aimed to address the gap in the research related to end-of-life counseling by exploring the experiences of counselors working with clients at end of life. While counseling literature and education are lacking regarding end of life, many counselors will work alongside clients approaching death. The purpose of this study was twofold: (a) to better understand the nuanced experiences of counselors providing end-of-life counseling and (b) to explore the supports and preparations helpful for counselors to provide end-of-life counseling. A narrative approach, using the Listening Guide (Gilligan, 2015), was employed to analyze and present the stories of three …


Considerations Of Medicare Telehealth Services With Older Adults, Sonah Kho, Amanda Dediego Sep 2024

Considerations Of Medicare Telehealth Services With Older Adults, Sonah Kho, Amanda Dediego

Adultspan Journal

The onset of the COVID-19 pandemic set in motion a rapid expansion of mental health services offered via telehealth. With this rapid expansion came the need to examine how policy and practice should be shaped in a future where telehealth is considered common in counseling practice. For counselors to understand how to support older adult clients in using telehealth services, they must understand telehealth policy. Following the eligibility of licensed counselors to participate in Medicare, counselors need to stay abreast of regulatory changes regarding restrictions and regulations on use of telehealth for mental and behavioral health services, including video and …


Building Confidence, Diminishing Stress: A Clinical Incivility Management Initiative For Nursing Students, Younglee Kim, Phoebe (Yeon) S. Kim, Henrietta Nwamu, Anne Lama Sep 2024

Building Confidence, Diminishing Stress: A Clinical Incivility Management Initiative For Nursing Students, Younglee Kim, Phoebe (Yeon) S. Kim, Henrietta Nwamu, Anne Lama

Nursing Faculty Publications

Objective: The aim of this study was to evaluate the effectiveness of an interactive program designed to reduce nursing students’ perceived stress and improve self-efficacy and readiness to professionally address incivility during clinical practice. Background: Incivility in clinical settings adversely impacts learners, educators, institutions, and healthcare systems, undermining safety and the teaching–learning process. Despite its increasing global prevalence, effective interventions remain largely unexplored. Methods: Our mixed-methods study, conducted from March to April 2024, involved senior baccalaureate pre-licensure nursing students (N = 35) from a California State University. The three-week, one-hour-per-week, interactive clinical incivility management program was developed through an extensive …


Interprofessional Education To Support Alcohol Use Screening And Future Team-Based Management Of Stress-Related Disorders In Vulnerable Populations, Taylor Fitzpatrick-Schmidt, Scott Edwards Sep 2024

Interprofessional Education To Support Alcohol Use Screening And Future Team-Based Management Of Stress-Related Disorders In Vulnerable Populations, Taylor Fitzpatrick-Schmidt, Scott Edwards

School of Graduate Studies Faculty Publications

Introduction: Alcohol use disorder (AUD) is a psychiatric disease that affects approximately 10% of the population. Individuals suffer from a myriad of causes and consequences of AUD, and team-based management of patients is often required for given the chronic and complex nature of the disease. Interprofessional education (IPE) for biomedical science and health professional students that incorporates patient-centered cases focused on AUD and adjacent stress-related disorders may improve future collaboration in managing these conditions and community outcomes related to wellbeing. Methods: This study assessed the impact of a single, 90-minute IPE exercise on improving confidence in possessing the knowledge and …


Screening, Brief Intervention, And Referral To Treatment For Pregnant Women, Rebekah Feeney Sep 2024

Screening, Brief Intervention, And Referral To Treatment For Pregnant Women, Rebekah Feeney

Dissertations

Abstract

Background: In the United States, 10-20% of pregnant women reported using drugs during pregnancy. Current recommendations are to screen for drug use in all patients and provide a brief intervention and referral to treatment. The purpose of this quality improvement project was to evaluate the impact of implementing a standardized screening, brief intervention, and referral to treatment (SBIRT) protocol for first-trimester pregnant patients who are seen in the obstetrical department.

Methods: The Tobacco, Alcohol, Prescription Medication, and Other Substance Use (TAPS) screening tool was administered to first-trimester pregnant women, 13-45 years of age, seen in the obstetrical department from …


Development Of A Maturity Assessment Tool To Evaluate And Strengthen National Immunization Technical Advisory Groups (Nitags), Eliza Dryer, Abigail Shefer, Shalini Desai, Lance Rodewald, Magdalena Bastías, Nathalie El Omeiri, Sidy Ndiaye, Kori Cook, Louise Henaff, Erin Kennedy Sep 2024

Development Of A Maturity Assessment Tool To Evaluate And Strengthen National Immunization Technical Advisory Groups (Nitags), Eliza Dryer, Abigail Shefer, Shalini Desai, Lance Rodewald, Magdalena Bastías, Nathalie El Omeiri, Sidy Ndiaye, Kori Cook, Louise Henaff, Erin Kennedy

Staff and Researcher Publications

As dozens of new National Immunization Technical Advisory Groups (NITAGs) were established worldwide in the past decade, and as existing NITAGs continued to play an important role in vaccine policy, global NITAG partners recognized a need for a standardized assessment tool to evaluate and strengthen their functions. This article describes the development of the NITAG Maturity Assessment Tool (NMAT), a stepwise evaluation tool that assesses NITAGs on seven key indicators of structure and process. A draft tool was developed through an iterative, consensus-based process with an expert working group before it was piloted with an economically and geographically diverse convenience …


Clinical Correlates Of Perceived Stigma Among People Living With Epilepsy Enrolled In A Self-Management Clinical Trial, Martha Sajatovic, Martha Sajatovic, Jessica Black, Jacqueline Krehel-Montgomery, Grace Mcdermott, Joy Yala, Richard Barigye, Clara Adeniyi, Farren Briggs Sep 2024

Clinical Correlates Of Perceived Stigma Among People Living With Epilepsy Enrolled In A Self-Management Clinical Trial, Martha Sajatovic, Martha Sajatovic, Jessica Black, Jacqueline Krehel-Montgomery, Grace Mcdermott, Joy Yala, Richard Barigye, Clara Adeniyi, Farren Briggs

Faculty Scholarship

Background and Purpose: Stigma is a pervasive barrier for people living with epilepsy (PLWE) and can have substantial negative effects. This study evaluated clinical correlates of perceived stigma in a research sample of PLWE considered to be at high risk due to frequent seizures or other negative health events. Methods: Analyses were derived from baseline data from an ongoing Centers for Disease Control and Prevention (CDC)-funded randomized controlled trial (RCT) testing an epilepsy self-management approach. Standardized measures assessed socio-demographics, perceived epilepsy stigma, epilepsy-related self-efficacy, epilepsy self-management competency, health literacy, depressive symptom severity, functional status, social support and epilepsy-related quality of …


A Systematic Review And Meta-Analysis Of Non-Suicidal Self-Injury Among Incarcerated Juveniles, Chikira H. Barker, Justin Gibson, Rose Tusa, Charlotte Pearson, Aaron Mack, Sydney Sukhdeo, Rahn K. Bailey Sep 2024

A Systematic Review And Meta-Analysis Of Non-Suicidal Self-Injury Among Incarcerated Juveniles, Chikira H. Barker, Justin Gibson, Rose Tusa, Charlotte Pearson, Aaron Mack, Sydney Sukhdeo, Rahn K. Bailey

School of Medicine Faculty Publications

Non-suicidal self-injury (NSSI) most commonly occurs during adolescence, and it represents one of the highest risk factors for future suicidal behaviors. Understanding the prevalence, risk factors, and effective treatments in high-risk groups, such as adolescents who are criminally incarcerated, is of substantial importance. A systematic review was conducted on articles related to NSSI in incarcerated adolescents. The results of the meta-analysis found that the pooled estimated prevalence of NSSI in this population is 28% (95% CI: 0.21–0.36). Studies varied in their methods of measuring NSSI, with some relying on medical record reviews, unstandardized assessments, or standardized assessments. Several demographic, social, …


Animation As Therapy For Mental Health Treatment Across Diverse Populations And Contexts, A Literature Review, Daneile Tabana Sep 2024

Animation As Therapy For Mental Health Treatment Across Diverse Populations And Contexts, A Literature Review, Daneile Tabana

Expressive Therapies Capstone Theses

Scientific research has explored and identified the beneficial relationship between health and creative expression, recognizing art therapy as a source of healing. Animation has been newly recognized as an art therapy medium with potential for therapeutic healing and increased psychological well-being. This review of the literature on animation therapy explores the history of the modality’s interaction with the population observed and the effects of animation on the cognitive processes, discusses current theoretical orientations and treatment options for treating a range of conditions that affect mood, thinking, and behavior with animation therapy, and considers culturally informed and client-centered practices alongside traditional …


Ethical Limitations Of Using Ai To Predict And Diagnose Mental Health Disorders Based On Individuals’ Social Media Activity, Stella Bandawe, Sumarie Roodt, Zainab Ruhwanya Sep 2024

Ethical Limitations Of Using Ai To Predict And Diagnose Mental Health Disorders Based On Individuals’ Social Media Activity, Stella Bandawe, Sumarie Roodt, Zainab Ruhwanya

African Conference on Information Systems and Technology

Artificial Intelligence (AI) is developed with predictive tools and is used to predict and diagnose mental health disorders based on data mined on social media platforms. Despite the growth of its adoption, there is limited literature that explicitly states the ethical limits of this technology within the context of predictive mental health assessment. This study adopts a qualitative and deductive approach, it adopts the socio-technical systems theory which is evaluated using a systematic literature review approach focused on a data set of 40 documents. The results indicate that there are no clear regulations that define how much and what type …


Counseling In Virtual Spaces And Into The Metaverse: A Framework For Reflection, Conversation, And Future Scholarship, Staci Hayes, Yahyahan Aras, Kathy Caputo, James Hoag, Lindsay Ibos, Sania Khan, Kelly Smith Sep 2024

Counseling In Virtual Spaces And Into The Metaverse: A Framework For Reflection, Conversation, And Future Scholarship, Staci Hayes, Yahyahan Aras, Kathy Caputo, James Hoag, Lindsay Ibos, Sania Khan, Kelly Smith

Journal of Technology in Counselor Education and Supervision

Given the success of Virtual Reality (VR) in the gaming community and strides in mental health, both VR and the Metaverse provide limitless opportunities and possibilities in the field of counseling. This article aims to provide important definitions, an overview of the use of VR in clinical counseling, clinical supervision, counselor education and its potential emergence into the Metaverse. Implications are presented in hopes of prompting conversation on how we may accept technological and cultural shifts and remain true to our counseling roots. Specifically, how to maximize the potential benefits with counseling specific rationale and address the limitations and potential …


Pro-Vaccine And Anti-Vaccine Groups. Social Distance And Self-Assessment Of Scientific Skills, Sandrine Gaymard Sep 2024

Pro-Vaccine And Anti-Vaccine Groups. Social Distance And Self-Assessment Of Scientific Skills, Sandrine Gaymard

Journal of Social, Behavioral, and Health Sciences

The social distance scale developed by Bogardus decades ago, which allows us to measure levels of acceptance among members of diverse social, ethnic, or racial groups, has been widely used in different contexts. The objective of this study is to evaluate the social distance accepted by pro-vaccine and anti-vaccine groups. Following the principle of the Bogardus scale, a questionnaire was created regarding different degrees of closeness. Respondents also completed a scientific skills self-assessment. The population consisted of 193 people who declared themselves in favor of vaccination and 41 people who declared themselves against it. Statistical tests show significant differences regarding …


Association Between Unmet Needs And Happiness In Women Living With Breast Cancer In A Multiethnic, Middle-Income Setting, Nithiya Sinarajoo Sep 2024

Association Between Unmet Needs And Happiness In Women Living With Breast Cancer In A Multiethnic, Middle-Income Setting, Nithiya Sinarajoo

Student Works (2020-2029)

While improved breast cancer survival rates are commendable, healthcare professionals and stakeholders must acknowledge potential strains on the healthcare system and society if optimal support and survivorship programs are not established. A global shift towards personalized, holistic patient care is crucial. However, implementing such care in a low- and middle-income country like Malaysia faces significant barriers. Positive psychology, which focuses on fostering positive emotions, has shown promise in promoting better health and longevity in healthy populations. However, research on the concept of happiness, both as a predictor of health outcomes and as a patient-reported outcome in cancer settings, remains limited. …


A 6-Month, Prospective, Randomized Controlled Trial Of Customized Adherence Enhancement Versus A Bipolar-Specific Educational Control In Poorly Adherent Adolescents And Young Adults Living With Bipolar Disorder, Jennifer B. Levin, Molly Mcvoy, Joy Yala, Jessica Black, Carla Conroy, Martha Sajatovic Sep 2024

A 6-Month, Prospective, Randomized Controlled Trial Of Customized Adherence Enhancement Versus A Bipolar-Specific Educational Control In Poorly Adherent Adolescents And Young Adults Living With Bipolar Disorder, Jennifer B. Levin, Molly Mcvoy, Joy Yala, Jessica Black, Carla Conroy, Martha Sajatovic

Faculty Scholarship

Objective: Few studies have addressed medication adherence in adolescents and young adults (AYAs) with bipolar disorder (BD). This 6-month prospective randomized-controlled trial (RCT) tested customized adherence enhancement for adolescents and young adults (CAE-AYA), a behavioral intervention for AYAs versus enhanced treatment as usual (ETAU). Methods: Inclusion criteria were AYAs age 13–21 with BD type I or II with suboptimal adherence defined as missing ≥20% of medications. Assessments were conducted at Screening, Baseline, and weeks 8, 12 and 24. Primary outcome was past 7 day self-reported Tablets Routine Questionnaire (TRQ) validated by electronic pillbox monitoring (SimpleMed). Symptom measures included the Hamilton …


Preexisting Skin-Resident Cd8 And Γδ T-Cell Circuits Mediate Immune Response In Merkel Cell Carcinoma And Predict Immunotherapy Efficacy, Zachary Z Reinstein, Yue Zhang, Oscar E Ospina, Matt D Nichols, Victoria A Chu, Alvaro De Mingo Pulido, Karol Prieto, Jonathan V Nguyen, Rui Yin, Carlos Moran Segura, Ahmed Usman, Brittney Sell, Spencer Ng, Janis V De La Iglesia, Sunandana Chandra, Jeffrey A Sosman, Raymond J Cho, Jeffrey B Cheng, Ellie Ivanova, Sergei B Koralov, Robbert J C Slebos, Christine H Chung, Nikhil I Khushalani, Jane L Messina, Amod A Sarnaik, Jonathan S Zager, Vernon K Sondak, Charles Vaske, Sungjune Kim, Andrew S Brohl, Xinlei Mi, Brian G Pierce, Xuefeng Wang, Brooke L Fridley, Kenneth Y Tsai, Jaehyuk Choi Sep 2024

Preexisting Skin-Resident Cd8 And Γδ T-Cell Circuits Mediate Immune Response In Merkel Cell Carcinoma And Predict Immunotherapy Efficacy, Zachary Z Reinstein, Yue Zhang, Oscar E Ospina, Matt D Nichols, Victoria A Chu, Alvaro De Mingo Pulido, Karol Prieto, Jonathan V Nguyen, Rui Yin, Carlos Moran Segura, Ahmed Usman, Brittney Sell, Spencer Ng, Janis V De La Iglesia, Sunandana Chandra, Jeffrey A Sosman, Raymond J Cho, Jeffrey B Cheng, Ellie Ivanova, Sergei B Koralov, Robbert J C Slebos, Christine H Chung, Nikhil I Khushalani, Jane L Messina, Amod A Sarnaik, Jonathan S Zager, Vernon K Sondak, Charles Vaske, Sungjune Kim, Andrew S Brohl, Xinlei Mi, Brian G Pierce, Xuefeng Wang, Brooke L Fridley, Kenneth Y Tsai, Jaehyuk Choi

Staff and Researcher Publications

Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin cancer with a ~50% response rate to immune checkpoint blockade (ICB) therapy. To identify predictive biomarkers, we integrated bulk and single-cell RNA-seq with spatial transcriptomics from a cohort of 186 samples from 116 patients, including bulk RNA-seq from 14 matched pairs pre- and post-ICB. In non-responders, tumors show evidence of increased tumor proliferation, neuronal stem cell markers, and IL-1. Responders have increased type I/II interferons and pre-existing tissue resident (Trm) CD8 or Vδ1 γδ T cells that functionally converge with overlapping antigen-specific transcriptional programs and clonal expansion of public TCRs. Spatial …


Smart Toys For Sensing And Soothing Distress In Pediatric Patients, Jonathan Daniel Bonilla Sep 2024

Smart Toys For Sensing And Soothing Distress In Pediatric Patients, Jonathan Daniel Bonilla

Dartmouth College Master’s Theses

This thesis develops and evaluates child-centered technologies to support remote monitoring of pediatric patients, with an emphasis on childhood cancer and pediatric chronic pain. For these and many other health conditions, current therapies tend to focus on treating physical symptoms yet neglect the psycho-emotional aspects of managing the illness. However, such mental states play a major role in recovery. Research has shown that cancer patients with better mental health have better prognoses, higher possibilities of remission, and faster healing processes, while chronic pain patients with better mental health report lower levels of pain. To enable more personalized, continuous, and scalable …


Solubility Change Behavior Of Fluoroalkyl Ether-Tagged Dendritic Hexaphenol Under Extreme Uv Exposure, Hyun-Taek Oh, Gayoung Kim, Seok-Heon Jung, Yejin Ku, Jin-Kyun Lee, Kanghyun Kim, Byeong-Gyu Park, Sangsul Lee, Chawon Koh, Tsunehiro Nishi, Hyun-Woo Kim Sep 2024

Solubility Change Behavior Of Fluoroalkyl Ether-Tagged Dendritic Hexaphenol Under Extreme Uv Exposure, Hyun-Taek Oh, Gayoung Kim, Seok-Heon Jung, Yejin Ku, Jin-Kyun Lee, Kanghyun Kim, Byeong-Gyu Park, Sangsul Lee, Chawon Koh, Tsunehiro Nishi, Hyun-Woo Kim

Staff and Researcher Publications

This study focuses on the discovery of a single-component molecular resist for extreme ultraviolet (EUV) lithography by employing the ionizing radiation-induced decomposition of carbon–fluorine chemical bonds. The target material, DHP-L6, was synthesized by bonding perfluoroalkyl ether moieties to amorphous dendritic hexaphenol (DHP) with a high glass transition temperature. Upon exposure to EUV and electron beam irradiation, DHP-L6 films exhibited a decreasing solubility in fluorous developer media, resulting in negative-tone images. The underlying chemical mechanisms were elucidated by Fourier transform-infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy, and nanoindentation experiments. These analyses highlighted the possible electron-induced decomposition of C–F bonds in DHP-L6, leading …


Correspondence To "A Preliminary Study Of Collaborative Group Intervention With Recovered Peer Supporters For Eating Disorders: Analyses Including Comparisons Between In-Person And Online Sessions", Nirjal Thapa, Don D Shamilov, David F Lo Sep 2024

Correspondence To "A Preliminary Study Of Collaborative Group Intervention With Recovered Peer Supporters For Eating Disorders: Analyses Including Comparisons Between In-Person And Online Sessions", Nirjal Thapa, Don D Shamilov, David F Lo

Rowan-Virtua School of Osteopathic Medicine Departmental Research

We read with pleasure the article by Mochizuki et al., 1 titled “A preliminary study of collaborative group intervention with recovered peer supporters for eating disorders: Analyses including comparisons between in‐person and online sessions.” We would like to offer additional commentary on the conclusions regarding group intervention and peer support and its heavy influence on combating eating disorders. We hope these perspectives may provide insight into areas that may require further research and improvement.


Can Written Prompts Help Medical Residents To Accurately Monitor Their Own Communication Skills And Those Of Others?, F. O. De Meijer, N. Nyamu, A. H. De Bruin Sep 2024

Can Written Prompts Help Medical Residents To Accurately Monitor Their Own Communication Skills And Those Of Others?, F. O. De Meijer, N. Nyamu, A. H. De Bruin

Family Medicine, East Africa

In healthcare, effective communication in complex situations such as end of life conversations is critical for delivering high quality care. Whether residents learn from communication training with actors depends on whether they are able to select appropriate information or ‘predictive cues’ from that learning situation that accurately reflect their or their peers’ performance and whether they use those cues for ensuing judgement. This study aimed to explore whether prompts can help medical residents improving use of predictive cues and judgement of communication skills. First and third year Kenyan residents (N = 41) from 8 different specialties were randomly assigned to …


Psychiatric Polygenic Risk Scores: Experience, Hope For Utility, And Concerns Among Child And Adolescent Psychiatrists, Amanda R Merner, Page M Trotter, Lauren A Ginn, Jason Bach, Katherine J Freedberg, Takahiro Soda, Eric A Storch, Stacey Pereira, Gabriel Lázaro-Muñoz Sep 2024

Psychiatric Polygenic Risk Scores: Experience, Hope For Utility, And Concerns Among Child And Adolescent Psychiatrists, Amanda R Merner, Page M Trotter, Lauren A Ginn, Jason Bach, Katherine J Freedberg, Takahiro Soda, Eric A Storch, Stacey Pereira, Gabriel Lázaro-Muñoz

Center for Medical Ethics and Health Policy Staff Publications

Recent advances in psychiatric genetics have enabled the use of polygenic risk scores (PRS) to estimate genetic risk for psychiatric disorders. However, the potential use of PRS in child and adolescent psychiatry has raised concerns. This study provides an in-depth examination of attitudes among child and adolescent psychiatrists (CAP) regarding the use of PRS in psychiatry. We conducted semi-structured interviews with U.S.-based CAP (n=29) who possess expertise in genetics. The majority of CAP indicated that PRS have limited clinical utility in their current form and are not ready for clinical implementation. Most clinicians stated that nothing would motivate them to …


Reclaiming Healing Spaces: A Phenomenological Study On The Transformative Power Of Outdoor Therapy From The Lived Experiences Of Black Clinicians Working With Black Clients, Lynn Murphy Sep 2024

Reclaiming Healing Spaces: A Phenomenological Study On The Transformative Power Of Outdoor Therapy From The Lived Experiences Of Black Clinicians Working With Black Clients, Lynn Murphy

Dissertations

This phenomenological study involved assessing the experiences of Black therapists who engaged Black clients in outdoor therapeutic contexts. The study was founded on the existing literature that shows the quality of the therapeutic relationship is pivotal for client retention and the Western standards that have historically favored treatment within indoor environments. To contextualize this research, a comprehensive literature review was commenced, covering topics such as the decolonization of therapy, the historical and present-day relationship between Blacks and the outdoors in the United States, sedentary lifestyles, the psychological benefits of time spent in nature, various types of outdoor therapy, and the …