Digital Commons Network^™

Perceived Partner Substance Use, Genetic Predispositions, And Their Associations With Problematic Alcohol Use, Emotional Well-Being, And Relationship Quality, Megan E Cooke, Kathleen K Bucholz, Vivia V. Mccutcheon, Et Al.

2020-Current year OA Pubs

BACKGROUND: Romantic relationships are important contexts for substance use and emotional well-being. We tested the hypotheses that (i) genetic predispositions for alcohol consumption would be positively associated with partner substance use, (ii) partner substance use would moderate genetic influences on one's own alcohol outcomes, and (iii) partner discordance in substance use would be associated with lower emotional well-being and relationship quality.

METHODS: Analyses included 2,357 participants (M

RESULTS: Participant PGS

CONCLUSIONS: The results highlight the importance of partner substance use in etiological models of alcohol use, emotional health outcomes, and relationship quality.

Clinical Characteristics, Management, And Hematopoietic Cell Transplantation Of Patients With Tlr8 Gain-Of-Function, Danielle E Arnold, Jahnavi Aluri, Sarah S Mehta, Joshua M Tobin, Laura G Schuettpelz, Nermina Saucier, Elizabeth G Schmitz, Jeffrey J Bednarski, Megan A Cooper, Et Al.

2020-Current year OA Pubs

Toll-like receptor 8 (TLR8) gain-of-function (GOF) somatic variants were recently identified as causing severe neutropenia, lymphoproliferation, and immune dysregulation. We report the expanded clinical and laboratory phenotype and management of 10 patients, including the original cohort of 6 male patients. We identify the first female patient with TLR8 GOF who presented during infancy with pure red cell aplasia due to a germ line TLR8 variant, and 2 new disease-causing somatic variants in male patients. Eight patients had somatic mosaicism with peripheral blood variant allele fractions of 7% to 26%, and age of disease onset of 9 months to 28 years. …

Glomerular Basement Membrane Structural Integrity Dictates Trans-Tissue Deposition Of Laminin In The Kidney, Kohei Omachi, Meei-Hua Lin, Pongpratch Puapatanakul, Joshua F Begin, Karen K Mckee, Hironobu Fujiwara, Peter D Yurchenco, Jeffrey H Miner

2020-Current year OA Pubs

Basement membranes (BMs) are specialized extracellular matrices (ECMs) essential for tissue structure and function. In non-vertebrates, ECM components can be produced both locally and by distant tissues. In contrast, mammalian ECM has traditionally been considered to originate predominantly from adjacent or tissue-resident cells. The kidney glomerular basement membrane (GBM), composed of laminin-α5β2γ1 and collagen-α3α4α5(IV), is produced by neighboring cells and functions as a filtration barrier. Alport syndrome, a genetic kidney disease, is characterized by GBM structural defects and ectopic laminin-α2 deposition, but the source of this laminin remains unknown. Here, using CRISPR-Cas9 transgenic models, we demonstrated that ectopic laminin-α2 in …

Molecular Characterization Of Humanized Apoe Mouse Models Reveals Source And Genotype Dependent Differences, Na Wang, David M Holtzman, Et Al.

2020-Current year OA Pubs

BACKGROUND: Humanized APOE targeted-replacement (TR) mice are essential tools for studying apoE isoform effects in Alzheimer’s disease (AD) and other apoE-related disorders. Despite their widespread use, existing APOE mouse models, generated with different gene targeting strategies, have not been directly compared in terms of apoE isoform expression, lipid profiles, and transcriptomic signatures. Such differences could impact how we interpret APOE genotype-related outcomes, as well as related underlying molecular mechanisms. METHODS: We conducted a comprehensive molecular comparison of humanized APOE mouse models from three sources: Taconic Biosciences (TAC), the Cure Alzheimer’s Fund (CAF), and The Jackson Laboratory (JAX). We assessed apoE …

Association Between Charcoal Cooking Fuel And Cardiovascular Disease Prevalence In Haiti: A Cross-Sectional Analysis, Lily D Yan, Mark D Huffman, Et Al.

2020-Current year OA Pubs

BACKGROUND: There is little evidence on the association between cooking with polluting fuels, particularly charcoal, and heart disease from low- and middle-income countries, which have the highest burdens of polluting fuels and cardiovascular disease (CVD). We sought to assess the relationship between self-reported primary home cooking with charcoal and prevalent cardiovascular disease in the low-income country Haiti. METHODS: Demographic and clinical data were collected from 3,005 adults in the Haiti Cardiovascular Disease Cohort, recruited from Port-au-Prince using multistage random sampling from 2019 to 2021. Primary cooking fuel was self-reported in the household: charcoal orliquified petroleum gas (LPG). Prevalent CVD (heart …

Drug Procurement Methods And Challenges In Asian Low And Lower-Middle-Income Countries: A Systematic Review, Ferina Septiani Damanik, Anna Wahyuni Widayanti, Muhammad Qowiyul Amin

The Thai Journal of Pharmaceutical Sciences

Background: Pharmaceutical procurement plays a pivotal role in healthcare within Asian low and lower-middle-income countries (LLMICs), ensuring accessibility to essential, cost-effective, and high-quality medicines. Tailored approaches are imperative due to specific challenges inherent in these countries.
Objectives: This review examines several drug procurement systems in Asian countries with LLMICs while identifying and evaluating any potential challenges that might arise within the systems.
Materials and Methods: This review using the preferred reporting items for systematic reviews and meta-analyses guidelines and three search engines (PubMed, Science Direct, and Research Gate) employing Boolean search terms. The search focuses on drug procurement, medicine procurement, …

Efficacy And Safety Of Stem Cell-Based Interventions For Burn Wound Healing: A Systematic Review And Meta-Analysis Of Pre-Clinical And Early Clinical Evidence, Prayuth Poowaruttanawiwit, Patsanan Kulla, Naveeya Pakpoomkamonlert

The Thai Journal of Pharmaceutical Sciences

Background: Burn injuries remain a major therapeutic challenge, with conventional treatments often failing to achieve complete functional skin regeneration. Stem cell-based interventions, including mesenchymal stem cells (MSCs) and exosome derivatives, have demonstrated regenerative and immunomodulatory potential, yet their translation to clinical practice remains limited.
Objectives: To systematically evaluate the efficacy and safety of stem cell-based therapies for burn wound healing across pre-clinical and clinical studies.
Materials and Methods: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines, four databases (PubMed, Embase, Scopus, and Cochrane) were searched through April 2025. Eligible studies included randomized controlled trials and controlled pre-clinical …

Characteristics Of Drug-Related Problems And The Impact Of Pharmacist Interventions On Hospital Drug Costs In The Medical Intensive Care Unit, Sirima Sitaruno, Wanrada Binyala, Pattama Phetsuk, Nisrin Ni-Ngoh, Worakarn Nukong, Asama Saiwaree, Nawaporn Assanangkornchai, Tanatape Wanishayakorn

The Thai Journal of Pharmaceutical Sciences

Background: Pharmaceutical care activities have been reported to enhance treatment outcomes and cost-effectiveness in critically ill patients. However, relevant and timely data on this topic are still lacking in Thailand.
Objectives: The objective of the study is to investigate the characteristics of drug-related problems (DRPs) identified during pharmaceutical care activities at the medical intensive care unit (MICU) of a tertiary care teaching hospital in Thailand. In addition, we aimed to quantify the impact of pharmacist interventions on hospital drug costs.
Materials and Methods: DRPs identified during pharmaceutical care activities over 3 years were reviewed and classified by the Pharmaceutical Care …

Optimization Of Solvent Extraction For Polyphenols And Antioxidant Activity From Zanthoxylum Acanthopodium Leaves Using Simplex Centroid Design, Waras Nurcholis, Indah Z. Septiawati, Roni Kartiman, Surya Diantina

The Thai Journal of Pharmaceutical Sciences

Background: Zanthoxylum acanthopodium DC., locally known as andaliman, is an indigenous spice from North Sumatra, Indonesia, recognized for its high antioxidant potential. Despite its bioactive richness, optimization of solvent extraction for phenolic and flavonoid compounds from its leaves remains underexplored, even though these compounds are valuable for food and pharmaceutical applications. The use of solvents such as acetone in analytical extraction contexts is acceptable; however, further purification steps would be required for applications in food and pharmaceutical products.
Objectives: The main objective of this study was to optimize solvent combinations – comprising water, ethanol, and acetone – to maximize the …

Pharmacognostic Analysis And Thin-Layer Chromatographic Study Of The Thai Antipyretic Herbal Formula Khiao-Bencha-Khan, Sirinapa Chaisri, Tassanee Paraput, Pravit Akarasereenont, Pinpat Tripatara

The Thai Journal of Pharmaceutical Sciences

Background: Khiao-bencha-khan formula (KBF) is an herbal formula recorded in Thai scriptures and used to treat fever, including exanthematous fever, and aphthous ulcers. It consists of Limnophila rugosa (Roth) Merr., Bacopa monnieri (L.) Wettst., Gossypium arboreum L., Pogostemon cablin (Blanco) Benth., Eupatorium japonicum L., and Justicia gendarussa Burm.f.
Objectives: This study aimed to identify the pharmacognostic and chemical profiles of the herbal components found in KBF.
Methods: All authentic plant materials were collected, and samples were prepared under Pharmaceutical Inspection Co-operation Scheme/good manufacturing practice guidelines. The materials were identified using macroscopic, microscopic, and thin-layer chromatography (TLC) methods.
Results: Microscopic analysis …

Design Of Experiments Based Reversed-Phase High-Performance Liquid Chromatography Method For Estimation Of Metformin And Glimepiride In Combined Dosage Forms, Neela Manish Bhatia, Rachana Patil, Harinath More, Rutuja Dattatray Chougale

The Thai Journal of Pharmaceutical Sciences

Background: The present study aimed to systematically develop and validate a robust, rapid, and stability-indicating reversed-phase high-performance liquid chromatography (RP-HPLC) method for the simultaneous estimation of metformin and glimepiride in fixeddose combination tablets. Method development was guided by a design of experiments (DoE) approach using the Box-Behnken design (BBD) to ensure optimal analytical performance.
Materials and Methods: Chromatographic separation was achieved on a Cosmosil C18 column using an optimized mobile phase of acetonitrile and water (80:20, v/v) adjusted to pH 3.5. The flow rate was 1 mL/min, and detection was performed at 221 nm. The BBD approach systematically evaluated the …

Development Of Aqueous Dispersions Of Zein–Inulin Nanoparticles: Influence Of Formulation Variables On Physical Properties, Wanarat Sayamol, Supakarn Chamni, Jittima Chatchawalsaisin

The Thai Journal of Pharmaceutical Sciences

Background: Zein-based nanoparticles exhibit considerable potential for pharmaceutical and food applications. Incorporating inulin, a prebiotic polysaccharide, can improve their functional performance. Owing to the distinct solubilities of zein and inulin in aqueous ethanol, zein– inulin nanoparticles can be prepared through precipitation using their respective anti-solvents.
Objectives: This study aimed to systematically develop zein–inulin nanoparticles using the antisolvent precipitation method, with a focus on investigating the effects of formulation variables on particle characteristics and dispersion properties.
Materials and Methods: Zein–inulin nanoparticles were prepared using an anti-solvent precipitation method. Zein and inulin were separately dissolved in aqueous ethanol and water, respectively. The …

Medicines Security And Bioprospecting: A Future Agenda For Pharmaceutical Research, Geoffrey A. Cordell

The Thai Journal of Pharmaceutical Sciences

Humanity is at an extraordinary moment in history, where our interwoven future in Gaia depends on showing reverence for the modulation of our resource limits after significant losses of biodiversity and encroaching environmental change, including disappearing glaciers, rising sea levels, and changing climates. Engaging with the interconnectedness of all life on Earth and integrating sustainability and optimization of the valuable, renewable resources for future generations are essential beginning actions. Fostering economic and resource sustainability deepens the focus for contemporary research priorities toward assuring access to biological agents needed by the consumer/patient. Based on the outcomes of the COP28/29/30 and COP15/16 …

Tour Of Old & Rare Books Collection, Kelsey Koym, Tara Sims

History of Medicine Seminar

No abstract provided.

Understanding The Coach Learning Environment In Formal, Field-Based Settings: A Self-Determination Theory Perspective, Jody L. Langdon, Shayla Snow

Journal of Coach Development

Grounded in self-determination theory (SDT), the purpose of this study was two-fold: 1) to evaluate the psychometric properties of SDT-related measures in a sample of coach learners, and 2) to examine the relationships between need satisfaction and frustration, coach motivation, and engagement in training sessions.. A total of 796 coaches participated in the study, completing surveys measuring basic psychological need satisfaction and frustration, coaching motivation, and engagement. Aside from confirming the validity and reliability of measures for use among coach learners, findings indicate that satisfaction of basic psychological needs positively correlated with intrinsic motivation and engagement, while frustration of these …

Transcranial Alternating Current Stimulation As An Adjuvant For Nonfluent Aphasia: A Proof-Of-Concept Study, Lynsey M. Keator, Lisa Johnson, Roger Newman-Norlund, Kyler Spell, Samaneh Nemati, Leigh Ann Spell, Dirk B. Den Ouden, Christopher Rorden, Julius Fridriksson

Department of Speech-Language Pathology Faculty Papers

Effective rehabilitation tools are essential for improving language outcomes in chronic aphasia. Speech entrainment is a behavioral treatment that has shown promise in enhancing speech output in nonfluent aphasia, potentially by acting as an external mechanism to synchronize anterior and posterior language regions in the left hemisphere. Transcranial alternating current stimulation has been hypothesized to enhance functional connectivity between brain regions by amplifying endogenous oscillations. This proof-of-concept study explored whether high-definition tACS (HD-tACS) could improve speech fluency in nonfluent aphasia when paired with speech entrainment. In a double-blind, pseudorandomized study, 1 mA of HD-tACS at 7 Hz was applied to …

Best Integrated Writing Spring 2026 - Complete Edition, Wright State University School Of Humanities And Cultural Studies, Tracy Smith, Kristie Mckiernan

Best Integrated Writing

Best Integrated Writing includes excellent student writing from Integrated Writing courses taught at Wright State University.

Bacteriophage Therapy For Antibiotic-Resistant Infections, Shiva Pariyar

Best Integrated Writing

Pariyar examines bacteriophage therapy as a promising alternative to antibiotics for treating multidrug-resistant infections, highlighting its targeted mechanism, ability to disrupt biofilms, and synergy with antibiotics. While challenges such as regulation, immune response, and limited clinical trials remain, the study argues that advances in biotechnology and global collaboration position phage therapy as a future cornerstone in combating antimicrobial resistance.

Exploring The Impact Of Education On Cardiovascular Health In Women: Sex Disparities, Symptom Recognition And Attribution, And Preventive Measures, Sydney Totten

Best Integrated Writing

Totten examines sex disparities in cardiovascular disease among women, emphasizing gaps in symptom recognition, treatment, and health education. Through a literature review and educational intervention, it demonstrates that targeted, nurse-led education can significantly improve women’s understanding of risk factors, symptoms, and disease management, ultimately supporting better health outcomes.

Beyond The Chart: Clinical Decisions That Protect Patients, Stephanie Bell Kelsey, Rhea May Brasi, Carlisa Caso, Tida Chitmongran, Kieaira Cooksey, Erika Ferrell, Jacqueline Franke, Aizel Joyce Garrido, Lidia Geberslassie, Laurie Gillmore, Theo Hipos, Mindi Johnson, Heimy Jun, Robin Kanaan, Jiahui Li, Alexis Mangubat, Katia Marcu, Sara Mccarthy, Adithya Nath, Brenda Orozco, Maria Papageorge, Elizabeth Ruckman, Debbie Salcido, Aleczandrea Schmelzle, Vivian Stark, Kara Traynor

Nursing 711 Class Projects

The cases in this collection were written by graduate nursing students enrolled in the Master of Nursing program at the University of Nevada, Las Vegas School of Nursing. Each author drew from their own clinical experience to illustrate how structured reasoning shapes patient care at the bedside and beyond. Their willingness to reflect honestly on moments of uncertainty, advocacy, and judgment — and to share those reflections with students who are still developing their own — is the foundation of this work. This collection exists because of their generosity.

Psychology: Examining The Relationship Between Temperature Discrepancy And Reaction Speed, Jessica Berber, Yatri Patel, Yara Ali, Rileigh Schumacher

SPARK Symposium Presentations

Our study examines the interaction of temperature discrepancies and reaction speed in college students. Previous research suggests that temperature influences reaction time, with colder conditions generally slowing responses. However, comparatively little research has explored the effects of warmer temperatures on reaction speed. Therefore, the purpose of our study is to examine the relationship between temperature variation and reaction speed in college students. Participants will be recruited through word of mouth and the SONA pool. The SONA pool is used to recruit participants for studies, and they can sign up to fulfill course requirements or earn extra credit. In the Qualtrics …

Anxiety, Cognitive Load, And Simulation Effectiveness In Pre-Licensure Bsn Students, Brittany Behrens

Walden Dissertations and Doctoral Studies

High-fidelity simulation experiences are an integral component of pre-licensure nursing curricula, providing students with realistic, controlled environments to develop clinical judgement skills. While these simulations enhance learning, they can increase anxiety and cognitive load, potentially impairing students’ ability to process information and derive meaningful outcomes. The purpose of this quantitative, correlational study was to examine the relationships among pre-simulation anxiety, cognitive load, and perceived simulation effectiveness in pre-licensure BSN students. Data were collected from 90 participants using the shortened Spielberger State-Trait Anxiety Inventory (STAI), the Cognitive Load Measurement–Naïve Rating Questionnaire, and the Simulation Effectiveness Tool–Modified (SET-M). Pearson correlation analyses indicated …

The Epigenetic Effects Of Prenatal Diabetes On The Developing Vascular System- A Gsea Analysis, Daniel I. Telles Orellana

SPARK Symposium Presentations

Prenatal diabetes is a critical medical condition that extensively affects neonatal patients and their families. Numerous previous studies have suggested impairments in vascular development, size, and diversification; however, the molecular and gene regulatory mechanisms underlying these effects remain poorly understood. Understanding these mechanisms is essential for identifying potential therapeutic targets and improving treatment strategies. This study combined experimental zebrafish phenotypic analysis with re-analysis of publicly available RNA-seq data to investigate the effects of elevated glucose on embryonic vascular development. Zebrafish (Danio rerio) embryos were exposed to increasing glucose concentrations (1–3%) during early developmental stages. High glucose exposure showed …

Transcranial Alternating Current Stimulation As An Adjuvant For Nonfluent Aphasia: A Proof-Of-Concept Study, Lynsey M. Keator, Lisa Johnson, Roger Newman-Norlund, Kyler Spell, Samaneh Nemati, Leigh Ann Spell, Dirk B. Den Ouden, Christopher Rorden, Julius Fridriksson

Communication Sciences and Disorders Faculty Articles and Research

Effective rehabilitation tools are essential for improving language outcomes in chronic aphasia. Speech entrainment is a behavioral treatment that has shown promise in enhancing speech output in nonfluent aphasia, potentially by acting as an external mechanism to synchronize anterior and posterior language regions in the left hemisphere. Transcranial alternating current stimulation has been hypothesized to enhance functional connectivity between brain regions by amplifying endogenous oscillations. This proof-of-concept study explored whether high-definition tACS (HD-tACS) could improve speech fluency in nonfluent aphasia when paired with speech entrainment. In a double-blind, pseudorandomized study, 1 mA of HD-tACS at 7 Hz was applied to …

Dietary Inflammatory Index And Objective Disease Activity In Ibd: No Association Found, Rúbia Moresi Vianna De Oliveira, Ana Carolina Junqueira Vasques, Stefhani Andrioli Romero, Nitin Shivappa Mbbs, Mph, Ph.D., Michael David Wirth, James Hébert Scd, Glaucia Fernanda Soares Ruppert Reis, Cristiane Kibune Nagasako

Faculty Publications

Background

Inflammatory Bowel Disease (IBD) involves genetic and environmental factors, but the relationship between disease activity, adiposity, and diet remains unclear.

Objective

To investigate the association between endoscopic/radiological activity of IBD, body adiposity, and the Dietary Inflammatory Index with or without adjustment for energy density (E-DII or DII).

Method

An observational, cross-sectional study was carried out. Endoscopic activity was defined by an endoscopic Mayo score >2, Crohn’s Disease Endoscopic Index of Severity (CDEIS) > 5, and/or the presence of a deep ulcer in any intestinal segment. Body adiposity was estimated using the body mass index, waist circumference, and waist-hip ratio (WHR). …

Transcranial Alternating Current Stimulation As An Adjuvant For Nonfluent Aphasia: A Proof-Of-Concept Study, Lynsey M. Keator, Lisa Johnson, Roger Newman-Norlund Ph.D., Kyler Spell, Samaneh Nemati, Leigh Ann Spell, Dirk B. Den Ouden, Chris Rorden, Julius Fridriksson Ph.D.

Faculty Publications

Effective rehabilitation tools are essential for improving language outcomes in chronic aphasia. Speech entrainment is a behavioral treatment that has shown promise in enhancing speech output in nonfluent aphasia, potentially by acting as an external mechanism to synchronize anterior and posterior language regions in the left hemisphere. Transcranial alternating current stimulation has been hypothesized to enhance functional connectivity between brain regions by amplifying endogenous oscillations. This proof-of-concept study explored whether high-definition tACS (HD-tACS) could improve speech fluency in nonfluent aphasia when paired with speech entrainment. In a double-blind, pseudorandomized study, 1 mA of HD-tACS at 7 Hz was applied to …

Γδ T Cells At The Interface Of Innate And Adaptive Immunity In Cancer, Arnau Solé Casaramona, Martin F Bachmann, Eva Sevick-Muraca, Mona O Mohsen

The Brown Foundation: Institute of Molecular Medicine

γδ T cells are unconventional lymphocytes that bridge innate and adaptive immunity by combining recognition of stress-induced ligands independently of classical major histocompatibility complex molecules with the capacity to undergo clonal expansion and long-term adaptation. Their unusual ability to detect malignant transformation using semi-invariant T-cell receptors, butyrophilin recognition and natural killer-like receptors positions them as powerful effector cells in tumors that evade classical immune escape mechanisms. Furthermore, distinct γδ subsets have distinct phenotyping and specific tissue-residencies, which could be leveraged to modulate immunological responses. We evaluate engineered therapies and different experimental platforms for studying γδ T cell biology. We conclude …

Discordance Between Actual And Perceived Balance Ability Relates To Quality Of Life And Global Cognition In A Clinical Sample Of Parkinson Patients, Daniel S. Peterson, Jason K. Longhurst, Franziska Albrecht, Joanna Weller, Jennifer Vasquez, Myassar Zarif, Mark Gudesblatt, Andrew Hooyman

Physical Therapy Faculty Articles and Research

Background

Objective

Methods

Improving Depression Screening For African American Adolescents Through Staff Education On The Phq-A, Yvonne Anutatu Nkeze

Walden Dissertations and Doctoral Studies

Improving Depression Screening for African American Adolescents Through Staff Education on the PHQ-A

Circulating Levels Of Insulin-Like Growth Factor I (Igf-I) And Risk Of Multiple Myeloma: An Observational And Mendelian Randomisation Study, Yolanda Benavente, Sara Hermosa, Nikos Papadimitriou, Alyssa I. Clay-Gilmour Ph.D., Elizabeth E. Brown, Jonathan N. Hofmann, Nathaniel Rothman, Qin Lan, Sonja I. Berndt, Demetrius Albanes, Mark Purdue, Mitchell J. Machiela, Stephen J. Chanock, Parveen Bhatti, Wendy Cozen, Aaron Norman, Susan L. Slager, James R. Cerhan, Vincent Rajkumar, Et. Al.

Faculty Publications

No abstract provided.