Digital Commons Network^™

Declaring Futility After Traumatic Injury And The Burden Of Failure On The Surgeon, Jan-Michael Van Gent, Bryan A Cotton

Faculty, Staff and Student Publications

In this edition of the THOR supplement in Transfusion, there are two articles that deal with resuscitation futility and transfusion. In one article, Yazer et al. delve into the details of the studies outlined in this editorial and summarize the literature on the topic of transfusion and futility. The second article by Dr. Jay Malone discusses the ethical issues surrounding massive transfusion and resuscitation. Taken together, these articles address the clinical and ethical issues surrounding this very emotive and difficult topic.

The Impact Of Rapid Infusers On The Hemostatic Potential Of Cryoprecipitate Products, Connor D Purvis, Samantha Redden, Andrew Jacobson, Yao-Wei Wang, Julie Campbell, Jessica Cardenas, Jan-Michael Van Gent, Bryan A Cotton

Faculty, Staff and Student Publications

Background: In cases of massive transfusion, intravenous access can be limited. Additionally, delivering different products through separate lines and infusion methods adds unnecessary steps. RBC, plasma, and whole blood (WB) are delivered via rapid infusers; cryoprecipitate (CRYO) is infused through separate access and is not approved with these devices.

Study design and methods: We examined the impact of different transfusion methods on hemostatic performance and factor activity using two available CRYO products. Ten bags of CRYO, ten bags pathogen-reduced CRYO (Intercept® Fibrinogen Complex, IFC), and 20 units of WB were obtained. Each CRYO bag was infused with one unit of …

Estrogen As A Therapeutic Agent: Targeting Endotheliopathy And Coagulopathy In Trauma, Niruktha Raghavan, Mira Patel, Bryan A Cotton, Julia Coleman, Donald Jenkins

Faculty, Staff and Student Publications

Background: Traumatic injury remains a leading cause of death, often due to uncontrolled hemorrhage and trauma-induced coagulopathy (TIC). TIC is critically triggered by the endotheliopathy of trauma, involving endothelial cell injury and glycocalyx degradation. Despite conventional advances, the stable casualty rate underscores the urgent need for new precision resuscitation strategies that acknowledge factors like biological sex.

Design: The central hypothesis is that estrogen confers a survival advantage in hormonally active females through a dual action: endothelial cell stabilization (halting glycocalyx shedding) and its inherent procoagulant effect. The analysis assesses the therapeutic potential of both exogenous estrogen and female-derived blood products …

The Mysteries Of Postpartum Ocd: A Systematic Review, Taryn Shaffer

Honors Program: Senior Projects (Public)

Background: The research on postpartum mental health is growing, with most focusing on physical and sexual wellness, or well-known mental health symptoms such as psychosis, depression, and stress. However, as the research grows, so does the interest in lesser-known or under-considered postpartum mental health symptoms, including Obsessive-Compulsive Disorder (OCD). The focus of this research can be the exacerbation of already-present OCD symptoms, or the onset of them during pregnancy and the postpartum period. The purpose of this systematic review was to analyze research on OCD in pregnant and postpartum women. Specifically, the review included an analysis of measures used to …

Severe Transvalvular And Paravalvular Aortic Regurgitation As Late Tavr Failure Successfully Treated With Percutaneous Therapy, Ashley Armstrong, Luca Halalau, Ivan Hanson

Conference Presentation Abstracts

BACKGROUND - Transcatheter aortic valve replacement (TAVR) is an established therapy for severe aortic stenosis. With improving long-term survival, late prosthetic valve–related complications are increasingly recognized. CASE SUMMARY - We report a 74-year-old man who presented eight years after TAVR with progressive dyspnea, orthopnea, and bilateral lower extremity edema, identified to be acute decompensated heart failure with a new diastolic murmur. Transthoracic echocardiography demonstrated severe aortic regurgitation. Subsequent transesophageal echocardiography identified concomitant severe paravalvular and severe transvalvular regurgitation of the bioprosthetic valve. Invasive hemodynamic assessment revealed acute volume overload with markedly elevated filling pressures, secondary pulmonary hypertension, and right ventricular …

An Investigation Of Data Granularity In Rag Pipelines For Personalized Medicine, Paritosh Pandey

Master's Theses

Generative AI, exemplified by large language models like the OpenAI GPT and Meta LLaMA families, can produce diverse content in response to prompts. This capability offers a promising solution to challenges in precision medicine, which seeks to tailor treatments to individual clinical profiles but often struggles with data collection, cost, and privacy concerns. By generating realistic, privacy-preserving patient data, generative AI has the potential to transform patient-centric healthcare. With such motivation, this research develops a comprehensive Generative AI pipeline emphasizing data granularity for accurate prediction of personalized treatments. The pipeline features a central Large Language Model interacting with a Machine …

Social Correlates Of Trauma And Posttraumatic Stress Disorder: The Importance Of Context, Lukoye Atwoli, Linnet Ongeri

Internal Medicine, East Africa

Understanding trauma and posttraumatic stress disorder (PTSD) requires a contextual perspective that considers historical legacies, social environments, and cultural realities. This paper draws on empirical evidence from Kenya and Uganda to demonstrate the limitations of applying trauma frameworks developed in high-income countries to African contexts. Findings from the Orphaned and Separated Children’s Assessment Related to Their Health and Well-Being (OSCAR) study challenge assumptions about care environments. The study reveals higher PTSD rates among orphans in family-based settings compared to institutional care, and highlights the protective roles of religion and social support. The Neuropsychiatric Genetics of African Populations-Psychosis (NeuroGAP-Psychosis) study provides …

Observation And Reflection Of Neighborhood And Community 2026: Food Access, Housing, Religious Community, And Health Care Access Reflection, Celene Philip, Michaela Kizy, Haley Montgomery, Akash Dantuluri, Josh Hailo, Abdel Kareem Hilo, Shadi Charara, Sarah Schenck

Patient Education Projects

No abstract provided.

Observation And Reflection Of Neighborhood And Community 2026: Financial And Transportation Barriers, Hassan Hachouche, Matthew Spaulding, Mark Garmo, Michael Hwang, Alondra Prado, Abigail Margolis

Patient Education Projects

No abstract provided.

Observation And Reflection Of Neighborhood And Community 2026: Social Determinants Of Health: Food, Transportation, Healthcare Facilities And More, Eboni Sawyer, Jesse Hawkins, Sephora Dafinescu, Andrew Robinson, Dev Patel, Sara Mccurry, Lauren Collins, Brandon Rogers

Patient Education Projects

No abstract provided.

Observation And Reflection Of Neighborhood And Community 2026: Education Access/Quality, Economic Stability, Built Environment/Infrastructure And Team Reflection, Alan Carbajo, Samiollah Mohammad, Muhammed Zahriyeh, Grace Drexel, Aster Disbrow, Reagan Recchia

Patient Education Projects

No abstract provided.

Observation And Reflection Of Neighborhood And Community 2026: Employment, Education, Fitness, Healthy Food, Pharmacies, And Reflection, Annika Tekumulla, Vamsi Gollapalli, Sebastian Reczek, Alston Prabhu, Matthew Haerens, Ashna Mehra, Susan Dong, Madison Martin

Patient Education Projects

No abstract provided.

Observation And Reflection Of Neighborhood And Community 2026: Observation And Reflection Of Food Availability, Housing, Public Spaces, Recreation, And Healthcare In The Community, Celestino Mangulabnan, Melanie Kajy, Gabriel Hay, George Naguib, Arya Mohanty, Schednah Laraque, Charles Dickson

Patient Education Projects

No abstract provided.

Observation And Reflection Of Neighborhood And Community 2026: Education, Access To Healthy Foods, Neighborhood & Physical Environment, Economic Stability, Taylor Brown, Tanya Bhardwaj, Sara Komaiha, Duncan Mcleod, Jonah Harman, Jai Kukreja, Dominic Marsalese, Elizabeth O'Brien

Patient Education Projects

No abstract provided.

Observation And Reflection Of Neighborhood And Community 2026: Neighborhood & Built Environment, Social & Community Context, Health Care Access & Quality, Courtney Alexander, Sarah Okeke, Bashar Jawich, Joshua Weiss, Shoshana Leflein, Mitchell Finesilver, Liz Ana Palacios

Patient Education Projects

No abstract provided.

Observation And Reflection Of Neighborhood And Community 2026: Food Insecurity, Transportation, And Educational Scarcity, Cindy Shkembi, Adithi Voleti, Sumayah Ahmed, Amogh Govind, Rafid Farjo, Ravel Ray, Jerick Kim, Chidera Orabueze

Patient Education Projects

No abstract provided.

Observation And Reflection Of Neighborhood And Community 2026: Sdoh Needs: Food And Community Spaces Reflection, Mohamed Attie, Katie Gahn, Maggie Lomasney, Emerson Woodbury, Muhammad Hatim, Justinas Sapiega, Isaac Agranoff, Braysila Ford

Patient Education Projects

No abstract provided.

Observation And Reflection Of Neighborhood And Community 2026: Income, Education, Food Insecurity And Reflection, Tonia Jones, Habib Serhan, Shriya Karmarkar, Arham Kaiser, Mohammad Turaani, Andre Yazhbin, Jacob Kroll, Jennifer Park

Patient Education Projects

No abstract provided.

Observation And Reflection Of Neighborhood And Community 2026: The Employment Of Residents In 48203 & Its Impact, Mahmood Sanad, Michelle Wang, Steven Katzman, Nikhil Uppal, Alvin Dong, Yuting Ruan, Makayla Hickmon, Dhara Patel

Patient Education Projects

No abstract provided.

Observation And Reflection Of Neighborhood And Community 2026: A Reflection On The Limited Resources Available For A Healthy Lifestyle, Jana Hatahet, Steven Jones, Laila Shatela, Pegi Laci, Anushka Dalvi, Michael Becker, Albert Oh, Anthony Marquez

Patient Education Projects

No abstract provided.

Observation And Reflection Of Neighborhood And Community 2026: Provider Availability, Healthcare Coverage, Access To Healthy Food Options, Income, Neighborhood Walkability, And School/Education Reflection, Kayla Hogan, Elizabeth Ajaero, Muhammad Hashem, Alina Ciesielski, Amanda Elashoff, Erik Pedersen, Hamza Mohammad, Tyler Dawson

Patient Education Projects

No abstract provided.

Observation And Reflection Of Neighborhood And Community 2026: Social Determinants In Action: A Field Reflection On Community Health, Jamaica Jordan, Razanne Zaghloul, Raj Khuperkar, Lissette Valdez, Nathan Morren, Cole Duvall, Alexis King

Patient Education Projects

No abstract provided.

Observation And Reflection Of Neighborhood And Community 2026: Education, Environmental Conditions, And Food Insecurities Reflection, Skylar Hall, Badruddin Mahamed, Jenna Andersen, Evan Robyns, Andrew Singh, Julia Correll, Yousef El-Magharbel, Tiffany Adam

Patient Education Projects

No abstract provided.

Observation And Reflection Of Neighborhood And Community 2026: Observation And Reflection Of Transportation Needs, Aaron Crump, Mohamed El-Souri, Rawan Antar, Sriram Garapati, Olivia Fras, Jai Patel, Lucy Zhang, Laya Dasari

Patient Education Projects

No abstract provided.

Observation And Reflection Of Neighborhood And Community 2026: Neighborhood And Built Environment: Facilitating Safety, Community, And Preventative Health, Zachary Hart, Batoul Dabajeh, Maaz Munawar, Josie Mclearen, Theodore Belecciu, Laura Zvinys, Tarek Harhash, Emily Critchfield

Patient Education Projects

No abstract provided.

Observation And Reflection Of Neighborhood And Community 2026: Food Insecurity, Transportation, Healthcare Access, And Reflection, Mariann Hayek, Noah Weslock, Arya Mashraghy, Mahathi Krothapalli, Abhishek Thakur, Fatima Alemam, Kyle Kramer

Patient Education Projects

No abstract provided.

Observation And Reflection Of Neighborhood And Community 2026: Neighborhood, Environment, And Reflection, Olma Tadesse, Kush Amin, Devon Roe, Anjie Dinakin, Matt Minasian, Arisha Arain, Dave Sreedhar, Ashley Yuran

Patient Education Projects

No abstract provided.

Observation And Reflection Of Neighborhood And Community 2026: Food Desert, Walking Infrastructure, And Primary Care Access Observed In 48203, Christina Barchini, Jad Fawaz, Brayden Moore, Emma Pastoor, Samuel Rest, Hamed Selemani

Patient Education Projects

No abstract provided.

Observation And Reflection Of Neighborhood And Community 2026: 48219 Beyond The Zip Code, Justin Darragh, Adhithi Keerthana Athikumar, Muaaz Akhtar, Dania Zeidan, Nathaniel Edwards, Trina Alimi, Jonah Brand, Beatrice White

Patient Education Projects

No abstract provided.

Observation And Reflection Of Neighborhood And Community 2026: Understanding Social Determinants In 48203, Jared Lin, Ryan The, Russell Elkus, Aayushi Jani, Michaela Yamine, Riona O'Donnell, Mariam Duhaini

Patient Education Projects

No abstract provided.