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Oral Insulin Nanoparticles In Animal Models Of Diabetes: A Systematic Review Of Recent Studies, Dhea Rahmania, Shaum Shiyan, Yulianto Kusnadi, Subandrate Subandrate, Juliana Palungan, Ayeshah Augusta Rosdah

Pharmaceutical Sciences and Research

Oral insulin has long been explored as a potential alternative to injectable insulin therapy. However, the development remains challenging due to enzymatic degradation in the gastrointestinal tract and limited intestinal absorption. Nanoparticle-based delivery systems have also been proposed as a strategy to protect insulin and improve uptake after oral administration. Therefore, this systematic review aimed to summarize recent preclinical studies investigating oral insulin nanoparticles in diabetic animal models and examine the reported pharmacological outcomes. Relevant studies were identified through database searches in PubMed, SpringerLink, and ScienceDirect using predefined keywords related to oral insulin, nanoparticles, diabetes, and animal models. Articles published …

Diabetes Mortality In Georgia: Disparities, Social Determinants, And Rural-Urban Differences (2019-2021), Gwendolyn H. Cattledge, Temilola N. Luwoye, Gloria Elizabeth B. Ogionwo, Nyshanti B. Ross, Zachary M. Bremmer

Journal of the Georgia Public Health Association

Background: Diabetes mellitus remains a significant public health challenge globally and, in the U.S., notably impacts mortality. Georgia specifically faces a substantial burden, with disparities observed across populations and counties. Understanding the patterns and underlying drivers of diabetes-related deaths statewide is crucial for effective public health intervention.

Methods: This cross-sectional study analyzed age-adjusted diabetes mortality rates in Georgia from 2019-2021, using data from the Georgia Department of Public Health's OASIS and the CDC's Social Vulnerability Index (SVI) 2020. The study aimed to detail the distribution of mortality rates across counties, explore the role of social determinants of health, and analyze …

Case Report: Beyond The Initial Diagnosis: A Case Of Wilson's Disease Presenting As Acute Decompensated Cirrhosis, Aun Bangash, Muhammad Ali Bangash, Chloe Harris, Veronica O'Brien, Learsi R. De Hoyos, Jose Campo Maldonado

School of Medicine Publications

Wilson disease is a rare inherited disorder of copper metabolism that can cause progressive hepatic injury, cirrhosis, and, in severe cases, acute liver failure. Its variable presentation can overlap with more common causes of liver disease and delay recognition. We present a 28-year-old patient with one week of worsening jaundice, right upper quadrant abdominal pain, nausea and vomiting, and marked hyperbilirubinemia. Given a history of heavy alcohol use and a Maddrey Discriminant Function score of 73, severe alcohol-associated hepatitis was initially suspected. However, several months of reported alcohol abstinence, a strong maternal family history of early-onset cirrhosis, imaging evidence of …

Building Resilience: The Role Of Extension In Enhancing Mental Health And Well-Being Through Preventive Approaches, Lakshmi Mahadevan

Journal of Extension

In 2023, 58.7 million U.S. adults experienced a mental illness, yet nearly half did not receive treatment (SAMHSA, 2023). Building Resilience is a single-session, evidence-informed program delivered through Cooperative Extension to address mental well-being using practical, nonclinical strategies. Grounded in Antonovsky's (1979) Sense of Coherence framework, the program centers on self-awareness, emotional regulation, and stress management within each participant's lived experience. Evaluation data from 347 participants showed high satisfaction, with 88% planning to apply strategies and 77% anticipating improved well-being. A 2-hour facilitator training supports national scalability, positioning Extension as a key partner in resilience-based mental health promotion.

Clinic White Paper: Usd Tele-Mental Health Training Clinic, Nicholas Boyd, Lauren Bruaski

Community Engagement

California is home to over 1.8 million veterans and 18,000 National Guard members, representing one of the largest military-connected populations in the United States. Despite substantial demand, over 50% of veterans experiencing mental health symptoms do not seek treatment, while those seeking care within federal systems frequently face significant wait times. This academic white paper evaluates the operational framework, clinical effectiveness, and workforce expansion model of the University of San Diego (USD) Tele-Mental Health Training Clinic – Veterans Initiative. Utilizing a secure, HIPAA-compliant telehealth model paired with a tiered supervision structure, the clinic provides evidence-based psychotherapies (EBPs) at no cost …

Bioactive Resin-Based Composites For Direct Posterior Restorations: A Contemporary Narrative Review, Ruaa Neamah Muslim, Ghadeer Shakir Shabaa, Wasan Abdulridha Hasan

Maaen Journal for Medical Sciences

Background and Rationale: Failure of dental restorations due to secondary caries remains one of the common problems in restorative dentistry. In order to solve the shortcomings of conventional bioinert materials, bioactive composite resins have recently been developed, allowing fluoride, calcium, and phosphate ion delivery as well as reducing the acidic activity of biofilm.

Aim of the Review: This literature review evaluates chemistry, mechanisms of action, clinical effectiveness, and physical handling properties of resin-based bioactive materials used for direct posterior restoration in permanent dentition.

Material Categories Examined: This literature review includes such material categories as resin-modified glass ionomers, S-PRG-giomers …

Pre-Procedural State Anxiety In Patients Scheduled For Colonoscopy, Zahraa Kareem Mansoor Al-Saady, Mohammed Hakim Shamran Al-Hchaim

Maaen Journal for Medical Sciences

Background: Anxiety is a common issue among patients undergoing invasive medical procedures such as colonoscopy because of concerns regarding the procedure itself and its possible results. High levels of anxiety can negatively affect patient readiness and cooperation during the examination, thereby influencing the quality and outcome of the procedure.

Study objective: To assess the prevalence and severity of pre-procedural anxiety among patients scheduled for colonoscopy and examine the association between socio-demographic and clinical characteristics and anxiety levels.

Methodology: A descriptive cross-sectional study design was employed to collect data from patients undergoing colonoscopy. A validated and comprehensive questionnaire tailored for individuals …

Role Of Perceived Control Over Falls In Older Adults, Kanjanaporn Tantrongphak, Kanthee Anantapong, Duangporn Suriyaamarit

Chulalongkorn Medical Journal

Falls among older adults constitute a significant public health challenge, often leading to severe physical injuries, reduced independence, and a diminished quality of life. Perceived control, a critical psychological construct, plays a significant role in sustaining physical health, cognitive function, and overall life satisfaction and is strongly associated with positive health outcomes. This review aims to examine the role of perceived control in fall risk among older adults. Concern about falling (CaF) is a prevalent psychological factor that influences fall risk by impacting behaviors linked to physical activity, balance, and adaptive responses. Perceived control theory provides a framework for understanding …

Pre-Excited Atrial Fibrillation In A Woman With Minimal Pre-Excitation: A Case Report, Komsing Methavigul

Chulalongkorn Medical Journal

Introduction: A 46-year-old Thai woman presented with palpitation. A 12-lead electrocardiogram (ECG) showed rapid rate of preexcited atrial fibrillation (AF). The subsequent ECG after electrical cardioversion demonstrated minimal preexcitation with short PR interval, and apparently small delta waves only in leads II, III, V₄, and V₅. An electrophysiologic study was performed and showed sinus rhythm with short H-V interval compatible with preexcitation. A programmed electrical stimulation showed orthodromic atrioventricular reentrant tachycardia utilizing left lateral accessory pathway. The catheter ablation was successfully performed via retrograde aortic approach to left lateral accessory pathway. There was no recurrence of …

Covid-19 Vaccination Is Associated With Lower Mortality And Intensive Care Unit Admission Among Hospitalized Patients With Covid-19: A Retrospective Cohort Study, Julian Madrid

Chulalongkorn Medical Journal

Background:

The development of vaccines has played a significant role in managing the pandemic of COVID-19. The objective of this study was to investigate the impact of COVID-19 vaccination on mortality and intensive care unit (ICU) admissions.

Methods:

This retrospective, single-center cohort study included hospitalized COVID-19 patients with confirmed vaccination status from July 2021 to February 2022. Outcomes such as mortality and ICU admission were evaluated using clinical data. We used logistic regression and advanced statistical methods, including LASSO regression, to analyze differences in hospitalized COVID-19 patients based on vaccination status.

Results:

The study encompassed 167 patients (69% male, mean …

Glutaraldehyde-Crosslinked Chitosan And Zinc Oxide Coating Reinforced With Polysulfone On Copper As A Platform For Electrochemical Formaldehyde Sensing, Anceu Murniati Anm, Rahmat Saputra Rs, Arie Hardian Ah, Manty Aldilani Ikaningsih Mai, Moh Haifan Haifan

Chimica et Natura Acta

Formaldehyde monitoring requires electrochemical platforms with stable structures and reliable interfacial responses. This study aimed to prepare and characterize a Cu|CS–GLA/ZnO–PSf composite film on a copper substrate as a platform for further formaldehyde-sensing development. The film was characterized using FTIR, SEM–EDX, XRD, and cyclic voltammetry. FTIR supported the presence of features associated with chitosan, imine, polysulfone, and Zn–O, while SEM–EDX revealed a heterogeneous polymer-rich coating with Zn- and O-containing domains distributed non-uniformly. XRD indicated a predominantly amorphous or poorly crystalline structure. Cyclic voltammetry showed scan-rate-dependent peak separations, with ΔEp increasing from 0.632 to 0.777 V in citrate buffer and from …

Editorial: Innovations In Dementia Policies And Services, Walter D. Dawson, Alison J. Canty, Joaquín Migeot, Laura O'Philbin, Sherril B. Gelmon

Institute on Aging Publications

There is an increasing global consensus that dementia is a significant public health issue (Chapman et al., 2006; Jackson et al., 2023; World Health Organization, 2017). As the global population ages and the number of people living with dementia increases, dementia will continue to grow in salience (Nichols, E., and GBD 2019 Dementia Forecasting Collaborators, 2022). The complexities associated with dementia require innovative approaches to the provision of care and support as well as to the design of service systems at local and national levels across the globe that can truly meet the unique needs of people living with dementia …

Investigating The Effect Of Oral Probiotic Capsules On Postpartum Sleep Quality In Primiparous Women: A Triple-Blind Randomised Controlled Trial, Maryam Rastegar, Nahid Jahani Shoorab, Roshanak Salari, Sedigheh Rastaghi

Sultan Qaboos University Medical Journal

Objectives: Quality of sleep is an important indicator of health. Sleep disturbance and daytime fatigue is one of the most common problems in the postpartum period. Early postpartum (first 4 weeks) is when sleep is most disturbed. The gut microbiota may affect sleep quality and affect host health through the production of metabolites and compounds. This study aimed to determine the effect of oral probiotic capsule on the quality of sleep after delivery in primiparous women. Method: This triple-blind randomised controlled trial study was conducted in August to November 2023 with eligible primiparous women who gave birth at Health Centers …

Intouch Week Of October 12, 2026, New York Medical College

InTouch

• $10 Million Department of Defense Award Fuels Effort to Advance Civilian and Military Tactical Medicine and Prolonged Casualty Care
• Advancing Knowledge, One Publication at a Time
• NYMC Expands Emergency Preparedness Training to More Than 300 Yonkers Public School Staff
• New Automated Staining Systems Enhance Histopathology and Imaging Core
• Graduate Student Leaders Step Forward to Shape the Year Ahead
• SMHW Hosts Together in Wellness Fair
• Strengthening GME Leadership Through Shared Learning
• Minimally Invasive Procedure Halves Risk of Recurrent Brain Bleeds

Modified Frozen Elephant Trunk Repair For Aortic Coarctation With Segmental Post-Stenotic Aneurysms, Pham Quoc Dat, Ma Nguyen Thai Hoang, Dang Van Phuc, Ta Dinh Do, Ngo Phi Long

Journal of the Saudi Heart Association

Aortic coarctation can be complicated by descending thoracic aortic aneurysms in adults. A 31-year-old man presented with exertional chest pain radiating to the back. Preoperative evaluation showed a 27-mmHg arm-leg systolic pressure gradient, echocardiographic coarctation with a 10-mm narrowest diameter and 25-mmHg gradient, and computed tomography showing two segmental post-stenotic aneurysms, the largest measuring 62 mm. He underwent one-stage modified frozen elephant trunk repair using a Medtronic thoracic stent graft sutured to a surgical graft. The postoperative gradient decreased to 5 mmHg, with stable 9-month follow-up.

Risk Factors Associated With Hair Loss Severity Among Female University Students: A Cross-Sectional Questionnaire-Based Study, Roaa Mohammed Jabbar, Rusul Mahdi Abid

AUIQ Complementary Biological System

Hair loss is a frequent health problem of women and can have an adverse impact on physical appearance, body image and quality of life. Its development has been attributed to a number of demographics, lifestyle and clinical factors, but which factors have the greatest influence on its development is unknown. This study aimed to evaluate the relationship between the demographical, lifestyle and clinical parameters with hair loss severity among female university students. A cross-sectional study was conducted among female university students', and data collected using a structured questionnaire, and statistical analysis was performed using chi-square, one-way ANOVA and Tukey post …

Transcriptomic Data And Biomedical Literature Synergize In Finding Pharmacologic Gene Regulators, Rebecca Meyer-Schuman, Fisher Cherry, Yang Sui, Athanasios Papastathopoulos-Katsaros, Yi Zhong, Yidan Li, Tianyun Wang, Kelsey Hennick, Druha Karunakaran, Hanna Berk-Rauch, Zhandong Liu, Aravinda Chakravarti, Tomasz Nowakowski, Evan E Eichler, Huda Zoghbi

Faculty, Staff and Students Publications

Autism affects male individuals four times more often than female individuals, yet the basis of this sex bias remains unclear. One hypothesis is that this sex bias is due to genetic variants in X chromosome genes where haploinsufficiency causes neurodevelopmental disorders (NDDs). In heterozygous XX female probands, a complete loss-of-function variant in one of these genes often causes syndromic NDD, but the same variant is too deleterious for survival in hemizygous XY males. A mild hypomorphic variant, however, may be tolerated in a female carrier but may produce milder neurological phenotypes in a male proband. We tested this by investigating …

Community-Based Well Testing And Outreach To Mitigate Human Health Risk From Unsafe Drinking Water, W. Adam Sigler, Katharine Sutphen, Margaret J Eggers, Kaleena Miller, Michelle Grocke-Dewey

Journal of Extension

Twenty-two percent of groundwater wells tested nationwide have one or more contaminants above a health threshold, yet many private well owners are unaware of these risks because they have not tested their water. Researchers piloted a community well testing clinic for education/outreach and surveyed participants about outcomes. Two months later, 75% of participants with high or intermediate health risk water quality results had taken action or intended to, indicating that community private well testing clinics can be effective in mitigating human health risks from contaminated drinking water.

The Utilization Of Holographic Simulation For Specialized Patient Populations: A Feasibility Study, Laurie Neely, Jennifer E. Tucker, Amardeep Singh, Taylor Mort, Jeremy Fleischmann, Patrick Pabian

Journal of Innovation in Health Sciences Education

Introduction: The COVID-19 pandemic presented a unique set of challenges for health care education programs to prepare students to care for specialized patient populations. Lab experiences that incorporated real patients were restricted due to risk of infection. The use of simulation-based learning increased as an alternative to prepare students for the clinical setting. The purpose of this study was to examine students’ perception of holographic simulation (HS) and confidence in clinical observation skills of motor milestones in children in preparation for clinical practice before and after use of HS in the classroom

Methods: Subjects included 36 second year Doctor …

Rethinking Existing Extension Programming: A Foundation For Healthy Aging?, Nicholas J. Spokely, Sloane A. Montgomery, Kelsey J. Weitzel, Kristin A. Miller, Marta Novaes Oliveira, Stephen D. Ball, Breanne S. Baker

Journal of Extension

Muscle declines are becoming more prevalent in younger adults, driving the need for accessible exercise programs. The Stay Strong, Stay Healthy (SSSH) Extension program was developed for adults 60 years old or older, but for this study, we enrolled 135 participants aged less than 60 years old in rural and urban counties to assess if it could improve their muscle performance. We analyzed data with time and group comparisons using paired t-tests and 2 × 2 repeated measures ANOVAs. Younger adults significantly improved muscle performance after SSSH, and the results were similar between rural and urban counties. This study …

Impact Of A Head-To-Toe Assessment Simulation On The Self-Efficacy Of First Semester Nursing Students, Martin Dole

Nursing Faculty Publications

The transition into clinical practice presents significant challenges for first-semester nursing students, particularly related to self-efficacy and the ability to perform comprehensive patient assessments. Low self-efficacy may negatively influence clinical judgment, skill performance, and patient safety. The purpose of this Doctor of Nursing Practice project was to examine whether participation in a head-to-toe assessment simulation impacted general self-efficacy among first-semester nursing students. Guided by Bandura’s theory of self-efficacy, a quantitative, quasi-experimental, one-group pretest–posttest design was used to evaluate changes in self-efficacy following a high-fidelity simulation experience. A convenience sample of 42 first-semester Bachelor of Science in Nursing students participated in …

Have You Done Your Duty? Impact Of Direct Mailing Campaign On Septic System Owners' Maintenance Knowledge And Behaviors In Coastal Texas Watersheds, Audrey Mccrary, T. Allen Berthold

Journal of Extension

As part of a watershed protection plan, the Texas Water Resources Institute and AgriLife Extension Service developed and distributed an educational postcard (``mailer'') about septic system maintenance to mailing addresses outside of public sewer service areas. The mailer was distributed four times within 1 year. The impact of this mailer was evaluated with a retrospective pre/post-test within a mailed survey. Overall, the mailer was effective at increasing knowledge of septic system owners and prompting maintenance action. Mailers can be a cost-effective alternative for educational initiatives where the target audience is not able to or interested in in-person or online programs.

Real-World Experience Of Hepatitis C Treatment With Glecaprevir-Pibrentasvir During Pregnancy, L Madeline Mccrary, Megan R Curtis, Jeannie C Kelly, Jessica Elrod-Gallegos, Patrick Kojima, Patricia Werner, Jennifer L Mullersman, Tracey Habrock-Bach, Michael J Durkin, Laura R Marks

2020-Current year OA Pubs

Guidelines endorse antenatal hepatitis C virus treatment following shared decision making. No clinical trial or real-world data exist for glecaprevir-pibrentasvir (GLE/PIB). We report our experience with prenatal GLE/PIB in 14 patients. Ten patients completed treatment; all achieved virologic response by or at delivery, with no maternal or neonatal safety concerns.

Diopt: The Drsc Integrative Ortholog Prediction Tool, 2026 Update, Yanhui Hu, Aram Comjean, Chenxi Gao, Austin Veal, Shinya Yamamoto, Stephanie E Mohr, Norbert Perrimon

Faculty, Staff and Students Publications

Mapping orthologous proteins is a critical step for cross-species literature mining, data integration, experimental design, and more, making the ability to quickly predict orthologs across species a key tool for functional genomic studies. The DRSC Integrative Ortholog Prediction Tool (DIOPT) was initially developed in 2011 to provide a centralized portal for identifying inferred orthologs among major model organisms. By integrating results from multiple ortholog prediction algorithms, DIOPT allows users to compare predictions across methods and prioritize high-confidence ortholog relationships. Over the years, we regularly updated the underlying genome annotations and refreshed predictions from each integrated algorithm. In addition, both the …

Depressive, Anxiety, And Stress Symptoms Among Respiratory Therapists In Two Tertiary Hospitals In Saudi Arabia: Differences According To Sociodemographic Characteristics, Budour Almutairi, Atheer Alsubaie, Reem Alenzi, Hala Alghemlas, Khalid Almutairi, Fouad Almutairi, Mansour Alshoaibi, Yaser Alnafea, Mona Almutairi, Salem Alqahtani

Journal of Medical Rehabilitation Science

Background: Respiratory Therapists (RTs) work in high-stress environments, predisposing them to psychological distress. This study evaluated the proportion of depressive, anxiety, and stress symptoms and their differences across sociodemographic groups among RTs in two Saudi Arabian tertiary hospitals.
Methods: This cross-sectional study was conducted between March and September 2023 at two tertiary hospitals in Jeddah and Riyadh. Out of 355 invited RTs, 112 completed an online questionnaire comprising sociodemographic items and the validated Depression, Anxiety, and Stress Scale-21 (DASS-21).
Results: Of the 112 participants, 61.6% were female, 47.3% were married, and 58.0% were Saudi nationals. The overall proportion of participants …

Analysis And Study Of The Content Of Chloride Salts In Oil, Natalia Evgenievna Sheina, Muborak Akramovna Mirshomilova

Technical science and innovation

The article addresses the critical issue of crude oil quality control, specifically focusing on the determination of chloride salts (sodium, calcium, and magnesium), which exert a destructive impact on processing equipment. The paper provides a detailed analysis of the adverse effects of salts, which lead to severe equipment corrosion, scaling, and a reduced yield of valuable oil fractions. The chemical principles and specific applications of two standardized methods for analyzing aqueous extracts according to GOST 21534-2021 and ASTM D3230 are described: indicator (argentometric and mercurimetric) and potentiometric titration. The experimental section presents the results of a comparative analysis of crude …

Social Media Use And Health Literacy Among Patients With Multiple Sclerosis In Saudi Arabia: A Cross-Sectional Study, Alaa Mohammad Arafah, Fatima Kherdm, Remas Alharbi, Noor Baswaid, Badr Fahad Alduqsi, Fayaz Khan

Journal of Medical Rehabilitation Science

Background: Health literacy (HL) plays a critical role in managing chronic conditions, as it empowers patients with MS to effectively access, understand, and apply health information to improve their well-being. With the rising prevalence of MS in Saudi Arabia, understanding the role of social media in health communication and its relationship with the health literacy of patients with MS is essential.
Objectives: This study aimed to estimate the health literacy levels among patients with MS in Saudi Arabia and investigate association between social media use and level of health literacy.
Methods: A cross-sectional study was conducted among 110 adult patients …

Are Accountability Courts In Georgia A Cost-Effective Public Health Policy Alternative?, Brian D. Graves, Orion Mowbray, Leaanne Derigne, Holly Lynde, Angel Ellis, Rachel Meyer

Journal of the Georgia Public Health Association

Background: This study evaluates the cost-effectiveness of accountability courts in Georgia, presenting them as a viable alternative in public health policy.

Methods: The research utilized survey data collected from 37 court programs across 40 distinct accountability court programs; it was conducted by the University of Georgia’s Carl Vinson Institute of Government in collaboration with the Council of Accountability Court Judges. The analysis includes a comparative assessment of cost savings, benefits, and differences among various court types, specifically focusing on drug courts, DUI courts, mental health courts, family treatment courts, and veterans treatment courts.

Results: Results reveal that …

Environmental Predictors Of County-Level Drowning Rates In Georgia, Jeff Turner

Journal of the Georgia Public Health Association

Background: Recent increases in drowning rates, both nationally and within Georgia, have led to renewed interest in the individual, situational/behavioral, and environmental characteristics that impact drowning. This study examines the association between two environmental characteristics, natural surface water coverage and public pools, on drowning fatalities and drowning-related ER visits by county in Georgia

Methods: We gathered county-level data on drowning fatalities and drowning-related ER visits and the number of public pools from the Georgia DPH, surface water coverage from the US Census Bureau, and demographic measures from the CDC. We conducted a linear regression analysis to identify how …

How To Improve Neonatal Beef Calf Health: A Hands-On Workshop Approach, Gabriele Maier, Essam Abdelfattah, Erik Fausak

Journal of Extension

Even though failure or inadequate transfer of passive immunity in beef calves is common, few interventions on the ranch address the issue. A workshop series that used calf simulators and live calves improved rancher knowledge on passive transfer and other topics relevant to neonatal calf health across operation sizes and experience levels. At the conclusion of the workshop, participants expressed a positive attitude towards using pain control for painful procedures in calves, with cost being the most important reason for not using it. Based on participant feedback, roundtable discussions would improve the workshop format.