Digital Commons Network^™

Effects Of A Virtual Reality-Based Nature Video Intervention On Sleep Quality And Mental Well-Being In Patients With Multiple Sclerosis: A Randomized Controlled Trial ​, Hati̇ce Yağci Karamanli, Nuray Bi̇ngöl

Turkish Journal of Medical Sciences

Background/aim: Sleep quality and mental health are negatively affected in many patients with multiple sclerosis (MS). The study was conducted to evaluate the effects of virtual reality (VR) on sleep quality and mental well-being.

Materials and methods: The study was designed as a randomized controlled trial. Data were collected from patients with MS who presented to a hospital in Türkiye. The study was completed by 21 participants in the experimental group and 22 participants in the control group. Participants in the experimental group watched nature videos using VR headsets for 6 weeks. Participants completed the Pittsburgh Sleep Quality Index (PSQI) …

Posture And Musculoskeletal Symptom Burden, But Not Daily Step Count, Are Independently Associated With Physical Quality Of Life In Office Workers: A Cross-Sectional Study ​, Gülsemi̇n Ertürk Çeli̇k, Abdurrahman İskender, Ahmet Usta, Alper Doğanci

Turkish Journal of Medical Sciences

Background/aim: Office work is characterized by prolonged sitting and may be accompanied by musculoskeletal symptoms and reduced well-being. This study examined associations of step-based and self-reported physical activity, clinical posture, attitudes toward sports, smartphone addiction, and musculoskeletal symptom burden in office workers with the four domains of the World Health Organization Quality of Life Scale-Brief Version (WHOQOL-BREF).

Materials and methods: This cross-sectional analysis included 44 desk-based office workers at a public institution. WHOQOL-BREF domain scores were transformed to a 0–100 scale. Physical activity was assessed via 7-day average daily step counts and the International Physical Activity Questionnaire-Short Form (IPAQ-SF); posture …

Effects Of Topical And Systemic Pirfenidone On Postlaminectomy Epidural Fibrosis In A Rat Model ​, Özgür Öcal, Zuhal Yildirim, Ayşe Çakir Gündoğdu, Abdurrahi̇m Taş, Betül Yaman, Abdurrahman Çeti̇n, Gökhan Gürkan, Abdurrahman Aycan

Turkish Journal of Medical Sciences

Background/aim: To investigate the effect of topical and systemic administration of pirfenidone (PFD) on the development of postlaminectomy epidural fibrosis in a rat model.

Materials and methods: A total of 32 male Wistar albino rats were randomly assigned to four equal groups (n = 8 per group). A bilateral total L1–L2 laminectomy was performed using a posterior midline microsurgical approach. The control group received only laminectomy; the sterile saline (SF) group received laminectomy followed by irrigation with sterile saline; the topical pirfenidone (PFDTpc) group received laminectomy followed by topical PFD application at the laminectomy site; and the systemic pirfenidone (PFD-Sys) …

Lipopolysaccharide-Induced Acute Systemic Inflammation Is Associated With Depression-Like Behavior And Increased Hippocampal Epha4 Expression ​, Senem Esi̇n Yavaş, Özkan Yavaş, Ayşe Akbaş, Seda Işiklar, Semi̇ha Ersoy

Turkish Journal of Medical Sciences

Background/aim: Depression is a prevalent neuropsychiatric disorder with a complex etiology and a higher burden in women. The inflammation hypothesis, initially proposed based on parallels between depression and sickness behavior, has gained increasing support from accumulating evidence. EphA4, a regulator of synaptic plasticity, is highly expressed in the hippocampus and functions as a negative modulator of neuroplasticity.

Materials and methods: Hippocampal EphA4 expression was investigated in female Wistar rats subjected to lipopolysaccharide-induced acute systemic inflammation. Acute systemic inflammation was induced by intraperitoneal administration of lipopolysaccharide (5 mg/ kg). Depression-like behaviors were assessed using the open-field test and tail-suspension test, while …

Effects Of Topical Glycerin And Hydrogen Peroxide On Auditory Brainstem Response Thresholds In A Rat Model Of Tympanic Membrane Perforation ​, Özlem Akkoca, Emi̇ne Aydin, Şule Demi̇rci̇, Ridvan Hali̇t Pamuk, Emi̇ne Ceren Ersöz Ünlü, Harun Çoban, Yüce İslamoğlu

Turkish Journal of Medical Sciences

Background/aim: Cerumenolytic agents containing glycerin and hydrogen peroxide are widely used in clinical practice and are generally considered safe; however, their potential effects on hearing function in cases of tympanic membrane (TM) perforation have not been adequately investigated. This experimental study evaluated the potential ototoxic effects of glycerin and hydrogen peroxide in rats with TM perforations using auditory brainstem response (ABR) testing.

Materials and methods: Twenty healthy male Wistar albino rats with bilaterally induced near-total TM perforations were divided into four groups (n = 4–6 animals/group) and received topical saline, amikacin, glycerin, or hydrogen peroxide applications twice daily for 10 …

Psychological Distress Among Dental Students: A Comparative Study Of Preclinical And Clinical Stages ​, Ömer Faruk Sari, Eli̇f Albayrak, Muhammed Hi̇lmi̇ Büyükçavuş

Turkish Journal of Medical Sciences

Background/aim: Understanding the degree of psychological stress experienced by dental students, together with the contributing factors, is important for reducing the adverse effects of stress and improving student well-being. Accordingly, the present study examined psychological distress levels among dental students and compared psychological distress across different academic years.

Materials and methods: This cross-sectional study included all undergraduate students enrolled in a single 5-year dental faculty in Türkiye during the 2024–2025 academic year. The Kessler Psychological Distress Scale (K10) survey was administered to the students and 399 dentistry students filled out the survey completely.

Results: Statistically significant differences in K10 scores …

Comments On “Pregnancy Outcomes In Systemic Sclerosis Before And After Diagnosis: A Retrospective Nationwide Cohort Study” ​, Muhammad Faisal Shabbir, Muksh Maheshwari, Chand Raj, Maria Baloch

Turkish Journal of Medical Sciences

No abstract provided.

Effect Of Beverages With Varying Acidity On The Surface Microhardness Of Resin Composites: An In Vitro Study, Vishnu S, Shweta Purohit, Yashas Dm, Mangala G K, Chinnu Mary Jose, Athira Bs

International Arab Journal of Dentistry

Introductions: The increasing consumption of acidic beverages has raised concerns regarding their impact on the longevity of composite resin restorations. Surface microhardness is a critical parameter for evaluating the mechanical performance and durability of restorative materials.

Aim: To evaluate and compare the effect of beverages with varying acidity on the surface microhardness of different composite resin materials and to assess the relationship between beverage pH and microhardness reduction.

Materials and Methods: This in vitro experimental study included 140 disc-shaped specimens of four composite resins: Filtek Z350 XT, Tetric N-Ceram, Beautifil II, and Charisma Smart (n = 35 …

Evaluation Of Enamel Demineralization Around Bonded Lingual Retainers Cured Using The Transillumination Technique: An In Vitro Sem Study, Monis Raza, Achint Juneja, Udit Chaudhary, Anju Treesa Jacob, Vikas Thakur, Aayush Sudan

International Arab Journal of Dentistry

Introduction: Polymerization technique may influence enamel demineralization around bonded lingual retainers by affecting adhesive integrity.

Methods: Eighty-four mandibular incisors were randomly allocated to conventional curing (30 s), transillumination (30 s), or combined curing (15 s each). Specimens underwent pH cycling and were evaluated using scanning electron microscopy. Demineralization was scored (0–3), and linear lesion depth was measured. Data were analyzed using Kruskal–Wallis, Bonferroni, and Mann–Whitney tests (p ≤ 0.05).

Results: Combined curing significantly reduced demineralization compared with conventional and transillumination protocols (p < 0.001). Gingival regions showed significantly greater demineralization than occlusal regions across all groups.

Conclusions: Combined curing improved enamel preservation and may be an effective strategy for bonded …

Corrigendum To “Characterizing The Metabolites Of The Tyrosine-Kinase Inhibitor Pexidartinib In Mouse Feces, Urine, Plasma, And Liver” [J. Pharm. Biomed. Anal. 265 (2025) 117034], Xuan Qin, Si Chen, John M Hakenjos, Jian Wang, Lei Guo, Ashish Dogra, Zhaoyong Hu, Kevin R Mackenzie, Feng Li

Faculty, Staff and Students Publications

No abstract provided.

Comparing Condylar Parameters Assessed By Ultrasonic And Mechanical Axiography: An In Vivo Pilot Study, Mark Salame, Amine El Zoghbi, Marina Daher, Carole Abi Ghosn, Paul J. Boulos

International Arab Journal of Dentistry

Objectives: The objective of this clinical pilot study was to compare the condylar parameters (condylar path inclination and Bennett angle) obtained from two different axiographs: a mechanical axiography system and an ultrasonic axigraphy system, and thus to judge the reliability and degree of accuracy of the mechanical axiography compared with the ultrasonic axiography considered as a reference technique.

Methods: Eleven candidates, aged between 20 and 25 years, were selected (n = 11) following strict inclusion and exclusion criteria. Each individual underwent two axiographic recordings by a single experienced operator. The first one was done with an ultrasonic axiograph, …

Effectiveness Of Animated Video And Electronic Dental Booklet Among Children In Primary Healthcare Centers, Kediri, Indonesia: A Prospective Interventional Study, Arini Indriyasari, Sayekti Wahyuningsih, Indasah Ir, Yuli Peristiowati

International Arab Journal of Dentistry

Introductions: Dental caries and poor oral hygiene remain major public health problems among children in Indonesia. Conventional dental health education has shown limited effectiveness in achieving sustainable behavioral change. Digital media, such as an animated video and an electronic dental booklet (e-Saku Gigi), offer a promising strategy to improve oral hygiene behavior in children.

Aim: This study evaluated the effectiveness of a Dental Health Education (DHE) intervention using an animated video and e-Saku Gigi on oral hygiene status (OHI-S), dental caries experience (DMF-T), and the knowledge–attitude–behavior pathway.

Methodes: A two-stage design was used. The first stage employed an …

Destaining Of Stained Clear Aligners When Subjected To Different Cleaning Techniques: A Comparative In Vitro Analysis, Malik Cn Sadah, Raj Kumar Jaiswal, Amit Kumar Singh, Nishtha Srivastava, Stuti Raj, Ayushi Singh

International Arab Journal of Dentistry

Introduction: Clear aligners are widely used due to superior esthetics; however, staining and loss of transparency remain major clinical concerns. This study evaluated color changes in stained clear aligners after different destaining techniques.

Methods: In this in vitro comparative study, 40 new clear aligners were stained using coffee solution and divided into four groups: control, Invisalign cleaning crystals alone, crystals with ultrasonic cleaning, and crystals with motorized brushing. Color change was assessed using VITA Easyshade spectrophotometer, Adobe Photoshop LAB analysis, and Visual Analog Scale (VAS). Data were analysed using ANOVA, Tukey post hoc test, Kruskal–Wallis, and Mann–Whitney U …

Cholesterol Metabolism And Oral Health: An Integrative Review, Raíssa Colherinhas, Carla Guimarães Moutinho, Ana Cristina F Vinha, Carla Alexandra Lopes Andrade De Sousa E Silva

International Arab Journal of Dentistry

Background: This integrative review associated changes in cholesterol metabolism and oral diseases. Conditions such as periodontal disease, tooth loss and oral cancer may be influenced by imbalances in lipid levels through mechanisms involving inflammation, oxidative stress, and immune modulation.

Highlight: This review examined scientific studies published mainly in the last decade. The findings indicate consistent associations between hypercholesterolemia or hyperlipidemia and periodontal disease, diabetes mellitus, hypertension, cardiovascular conditions, peri-implant health, and tooth loss. Hypocholesterolemia was associated with oral squamous cell carcinoma. Periodontal disease was the most frequently investigated oral condition, representing almost half of the included studies.

Conclusion …

Psychological Therapy In The Management Of Temporomandibular Disorders: A Systematic Review, Pragatheeswari R, Kavitha M, Sarumathi T, Niveditha B, Barkavi Panchatcharam, Pavithra D, Samu Fathima A I, Vigneshwaran J

International Arab Journal of Dentistry

Aim: To evaluate the effectiveness of psychological therapy in the management of temperomandibular disorders compared to other treatment modalities.

Methodology: Studies were selected according to PICO criteria, considering the RDC/TMD as a reference, improvement of pain and psychological parameters were the primary outcomes. Data search was mainly carried out through electronic search in several renowned databases: PubMed, Embase, Scopus, Web of Science and Google scholar. The publications collected were published between 2010 and 2024. Randomized clinical trials that compared the efficacy of psychological treatment modality with other conservative treatment modalities were screened and evaluated. A total of 5 …

Stem Cell-Based Therapies In Periodontology And Implant Dentistry: A Systematic Review And Meta-Analysis, Abdullah Saeed, Marycris Padrigo

International Arab Journal of Dentistry

Introduction: Periodontal disease and peri-implantitis remain the leading causes of tooth and implant loss, and conventional regenerative procedures consistently fall short of full structural restoration. Stem cell therapies have emerged as a promising alternative, operating through multi-lineage differentiation, immunomodulation via paracrine signaling, and extracellular vesicle communication. Prior systematic reviews, however, lacked methodological rigor — omitting clustering adjustments, REML/HKSJ estimation, prediction intervals, and publication bias modeling.

Aim: This systematic review and meta-analysis evaluated whether stem cell therapy produces superior clinical and radiographic outcomes compared to cell-free controls in adults with periodontal or peri-implant bone defects.

Methods: Searches across …

Measuring And Understanding Geographic Inequities In Physician Distribution In The Philippines: A Multi-Method Study Protocol, Veincent Christian F. Pepito, Ryan Gabriel C. Molen, Julius R. Migriño Jr, Theo Prudencio Juhani Z. Capeding, Anne Rose D. Payumo, Hazel Ivy M. Jeremias, Karl R. Ubial, William C. Tiu, Manuel M. Dayrit

ASMPH Center for Research and Innovation (ACRI)

INTRODUCTION: The Philippines faces physician shortages, exacerbated by their propensity to practise in urban centres. Despite government placement programmes, recruitment and retention of physicians in many areas throughout the country remain difficult. This study aims to: (1) describe the distribution of general physicians and board-certified specialist physicians and (2) identify the individual, work environment, local environment, national environment and international environment factors that may influence physicians to establish their practice in areas with below-optimal physician-to-population ratios in the Philippines. METHODS AND ANALYSIS: To describe the distribution of general physicians and board-certified specialist physicians, we will map Philippine Health Insurance Corporation …

Evaluating The Quality And Safety Of A Nurse Practitioner-Led Virtual Clinic For Secondary Prevention In Stable Coronary Artery Disease: A Pilot Feasibility Study., Anwar Abdi, Holly Rector, Vivian Hung, Shadi Akhtari

Medical Education Articles

Background Virtual care offers a complementary pathway to in-person visits for managing coronary artery disease (CAD). This study evaluated the feasibility of a nurse practitioner (NP)-led interdisciplinary virtual clinic dedicated to secondary prevention for individuals with stable CAD.

Methods A feasibility study was conducted in an academic cardiology practice in Canada from July 2021 to July 2024. A convenience sample of adults ≥18 years of age with stable CAD was included; each participant received at least one annual NP-led video visit reviewed with a cardiologist asynchronously. Primary outcomes: 1) percentage of self-reported maintenance of guideline-directed medical therapies (GDMT) and achieving …

Multicentre Real-World Outcomes Of Reference Bevacizumab And Two Biosimilars In Treatment-Naïve Neovascular Age-Related Macular Degeneration ​, Eyüpcan Şensoy, Mehmet Çitirik, Burhan Başkan, Hasan Öncül, Abdullah Beyoğlu

Turkish Journal of Medical Sciences

Background/aim: Bevacizumab biosimilars are increasingly used as alternatives to reference bevacizumab in ophthalmic practice, but comparative real-world evidence in treatment-naïve neovascular age-related macular degeneration (nAMD) remains limited. In this study, the short-term anatomical, functional, and documented safety outcomes associated with bevacizumab, bevacizumab-bvzr (Zirabev), and bevacizumab-awwb (Mvasi) were evaluated in treatment-naïve patients with nAMD in a multicentre real-world setting.

Materials and methods: This multicentre retrospective cohort included 250 treatment-naïve eyes with nAMD from 16 centres in Türkiye that completed a 3-month loading regimen with the same bevacizumab agent. Central macular thickness (CMT) was the prespecified primary longitudinal outcome; best-corrected visual acuity …

Combined Effects Of Postdistillation Residue Blends From Medicinal Plants On In Vitro Ruminal Microorganisms, Enzymes, Nitrogen And Energy Efficiency, And Antioxidant Status, Mojtaba Akbari Shooshood, Javad Rezaei, Mahdi Ayyari, Yousef Rouzbehan

Turkish Journal of Veterinary & Animal Sciences

In this study, the combined effects of postdistillation residue blends, including pomace, wastewater, and their mixture, derived from rosemary (RO), fennel (FE), spearmint (SP), and rose (ROS), on in vitro microbial populations, enzymatic activities, fermentation, and antioxidant status were evaluated using the gas production technique. The three phytobiotic blends were MP (mixed pomace of RO, FE, SP, and ROS; 1:1:1:1 ratio), MW (mixed wastewater of RO, FE, SP, and ROS; 1:1:1:1 ratio), and MPW (mixed pomace–wastewater of MP and MW; 1:1 ratio). Each blend was used at 2% and 3% of diet dry matter (DM). The experimental diets were as …

Ethylcyanoacrylate Adhesive And Microperforated Polyethylene Tape For The Cutaneous Closure Of Bitches Following Unilateral Total Mastectomy, Leonardo Martins Leal, Fábio Rodrigo Castro Bastos, Joseneia Boeing, Gabriel Aguiar Pavilak, Isaac Romani, Tais Harumi De Castro Sasahara, Paola Castro Moraes

Turkish Journal of Veterinary & Animal Sciences

The use of ethylcyanoacrylate (Super Bonder®) adhesive and microperforated polyethylene tape (Transpore) for the cutaneous closure of extensive wounds following unilateral mastectomy was evaluated, and the healing process was clinically assessed. Included in the study were 15 bitches diagnosed with mammary neoplasia, aged 4–14 years and weighing 3–33 kg. All bitches underwent a 30–60 cm craniocaudal cutaneous incision through the skin in the ventral thoracoabdominal region. Following excision of the tumor and the entire mammary chain, the adjacent tissues were approximated with polyglecaprone 25 sutures. Skin-edge coaptation was achieved through the application of adhesive to half of each wound, while …

Investigation Of Feed Values With In Vitro Technique And Chemical Properties, Particle Size Of Total Mixed Rations Prepared In Commercial Dairy Farms, Özlem Karcioğlu, Betül Zehra Sariçi̇çek

Turkish Journal of Veterinary & Animal Sciences

This study was conducted to investigate the chemical and physical properties and feed values of total mixed rations used on dairy cattle farms in Ankara Province. Included in the study were three farms from each of the five districts of Ankara Province (atotal of 15 commercial dairy farms). Total mixed ration (TMR) samples were collected weekly from each farm over a 3-month period in 2025. The chemical composition (crude protein, crude fat, crude fiber, acid detergent fiber (ADF), neutral detergent fiber (NDF), and acid detergent lignin (ADL)), in vitro digestibility parameters (in vitro gas production (IVGP), methane production (MP), organic …

Optimizing Marination Methodology, Holding Temperature, And Holding Time To Upgrade The Physicochemical And Sensorial Attributes Of Japanese Quail (Coturnix Japonica) Breast Fillets, Naveen Uduwawithana, Ruvini Mutucumarana

Turkish Journal of Veterinary & Animal Sciences

The aim was to optimize the effect of meat marination method (unmarinated, tumbling, injection, and immersion), holding temperature (4 oC and 8 oC), and holding time (4 h, 8 h, and 12 h) on the physicochemical and sensorial properties of Japanese quail (Coturnix japonica) breast fillets. Ninety-six deboned breast fillets (mean weight ± SD; 10 g ± 2) from 42-day-old unsexed Japanese quails were marinated. Injection marination showed the highest uptake (p < 0.05). The method × temperature × time interaction (p < 0.05) was significant for cooking yield, meat pH, hardness, cooking loss, and surface color lightness (L*). The highest pH (p < 0.05) was reported when the unmarinated control was retained for 8 h. Tumbling marinated meat when held for 12 h at 8 oC yielded the maximum cooking yield (60.3%). The cooking loss was minimal in unmarinated, tumbled, and immersion-marinated meat when held for 12 h. Irrespective of the temperature, 4-h holding time caused the minimum meat hardness in all four treatments. Tumble-marinated meat when held for 12 h at 8 oC resulted in the minimum cooking loss, hardness, and lightness (L*), as well as the maximum cooking yield. Meat when held at 4 oC for 4 h following injection marination had the highest scores for color, aroma, marinade penetration, flavor, and overall acceptability. In conclusion, quail breast fillets when tumble-marinated and held at 8 oC for 12 h were the best in terms of overall meat quality. Quail breast fillets held for 4 h at 4 oC following injection marination were rated highest by the panelists.

Evaluation Of Apoptosis In Peripheral Blood And Milk Immune Cells During Lactation In Dairy Cows With Subclinical Mastitis, Mykola Mykolayovich Zhelavskyi

Turkish Journal of Veterinary & Animal Sciences

The lactation cycle is considered one of the most physiologically demanding periods in dairy cows and is accompanied by substantial immunological remodeling. In the present study, spontaneous apoptosis of lymphocytes, monocytes, and neutrophils was evaluated in clinically healthy Ukrainian Black and White dairy cows (n = 28, aged 3–5 years) during different stages of the lactation cycle: colostrum period (3–5 days), mid‑lactation (90–150 days), drying‑off (5–7 days), and dry period (12–20 days). A further group of 28 cows with subclinical mastitis confirmed by the California Mastitis Test was also included in the study. Peripheral blood and milk samples were collected …

Changes In Mohair Cortisol Concentration And Fiber Growth During Gestation In Angora Goats, Beyzanur Aköz, Erkan Pehli̇van

Turkish Journal of Veterinary & Animal Sciences

The hypothalamic–pituitary–adrenal (HPA) axis plays a central role in regulating long-term stress responses. Keratin-based matrices represent a noninvasive approach for assessing long-term HPA axis activity in farm animals. The present study investigates gestational changes in mohair cortisol concentration and mohair fiber length in Angora goats under routine farm conditions. Clinically healthy does (n = 29; 14 aged 1.5 years and 15 aged 2.5 years) were monitored during the breeding season, and pregnancy was confirmed in 16 does. Mohair samples were collected monthly, fiber length was measured, and cortisol concentrations were quantified using an ELISA. Mohair cortisol concentrations were not significantly …

The Use Of Case-Based Experiential Learning With First-Year Occupational Therapy Students: A Two-Year Pilot Study, Michelle Jackson

Journal of Applied Disciplines

Background: Understanding and applying biomechanical principles to participation in functional activities is vital to occupational therapy (OT) education. Exposure to such principles underlying prosthetic use and occupational engagement related to lower extremity (LE) limb loss provides opportunities to better understand these concepts as well as the role of OT with this population.

Method: An experiential learning framework was used to develop a three-phase, case-study-based pilot project, completed with first-year graduate-level OT students from two cohorts (n = 26, n = 31).  At the conclusion of the project, an anonymous Likert-style survey and a reflection assignment were completed by all students. …

Structuring Clinical Readiness Through The Core Model In Csd Graduate Education, Camille Byrd O'Quin, Elaine Reyna, Angela M. Riccelli, Jessica Bonner, Judy Platt, Nicole Bing

Teaching and Learning in Communication Sciences & Disorders

This article introduces the CORE Clinical Orientation Model, a conceptual framework designed to support early clinical readiness in speech-language pathology graduate education. Grounded in the field's shift from traditional site-based apprenticeship models toward more structured, faculty-supported approaches, the model addresses documented variability in early clinical supervision and student preparedness. The CORE Model is organized around four interrelated pillars: Clinical Foundations, Ongoing Reflection, Rigorous Clinical Application, and Engaged & Intentional Mentorship. Although the model was developed alongside a graduate clinical orientation course, the course represents one implementation of the framework. This article describes the theoretical and professional foundations of the CORE …

Exploring Graduate Students’ Perspectives Of Clinical Supervision In Speech-Language Pathology: A Qualitative Study Of Facilitators And Barriers, Andrew J. Clare, Joyce Maring

Teaching and Learning in Communication Sciences & Disorders

This qualitative study explored second-year graduate students’ perceptions of clinical supervision practices in Speech-Language Pathology (SLP), focusing on how specific aspects of the supervisory approach were experienced by students as either barriers or facilitators to their learning during clinical practicum experiences. Twenty graduate students from a single SLP program, each with experience in at least seven clinical practica, participated in semi-structured interviews. An inductive thematic analysis approach was used to examine the patterns in the students’ experiences. Two mirrored sets of themes emerged, reflecting the dual importance of relational and pedagogical aspects of supervision. Facilitators included supportive relationships and effective …

Evaluating The Link Between Metabolic Syndrome And Cognitive Dysfunction In People Who Use Cannabis: A Critical Review Of Mechanistic Pathways, Evidence Quality, And Future Research Directions, Ghadah Alharbi, Ahmad H. Alhowail, Ashraf Mahmoud Emara

Saudi Toxicology Journal

Background: Cannabis is the most commonly used internationally controlled substance worldwide, with increasing rates of heavy use and cannabis use disorder (CUD) among adolescents and adults. While epidemiological evidence links cannabis exposure to both metabolic dysfunction and cognitive impairment, these outcomes have been examined predominantly in isolation. The mechanistic relationship between metabolic syndrome (MetS) and cannabis-related cognitive deficits remains poorly characterized. Objective: This review critically appraises the evidence linking cannabis use to metabolic dysfunction and cognitive impairment, proposes an integrative ``Cannabis–Metabolic–Cognitive Axis'' model, and identifies gaps limiting causal inference in the existing literature. Key Findings: Human studies frequently report lower …

Oral Insulin Nanoparticles In Animal Models Of Diabetes: A Systematic Review Of Recent Studies, Dhea Rahmania, Shaum Shiyan, Yulianto Kusnadi, Subandrate Subandrate, Juliana Palungan, Ayeshah Augusta Rosdah

Pharmaceutical Sciences and Research

Oral insulin has long been explored as a potential alternative to injectable insulin therapy. However, the development remains challenging due to enzymatic degradation in the gastrointestinal tract and limited intestinal absorption. Nanoparticle-based delivery systems have also been proposed as a strategy to protect insulin and improve uptake after oral administration. Therefore, this systematic review aimed to summarize recent preclinical studies investigating oral insulin nanoparticles in diabetic animal models and examine the reported pharmacological outcomes. Relevant studies were identified through database searches in PubMed, SpringerLink, and ScienceDirect using predefined keywords related to oral insulin, nanoparticles, diabetes, and animal models. Articles published …