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The Pivotal Role Of Artificial Intelligence In Optimizing Pharmaceutical Formulation And Delivery, Ali Khidher Abbas, Mustafa M. Noori, Ibtihal Abdulkadhim Dakhil, Mohammed Hussain Al-Mayahy

Al-Esraa University College Journal for Medical Sciences

Artificial intelligence (AI) has emerged as a transformative technological paradigm within the pharmaceutical sciences, offering innovative and forward-looking solutions to surmount the inherent limitations associated with conventional drug development, formulation design, and therapeutic delivery systems. Traditional pharmaceutical methodologies frequently entail protracted development timelines, extensive experimental procedures, and substantial financial expenditures, particularly within the domains of formulation optimization and drug delivery design. The integration of AI-driven technologies – encompassing machine learning (ML), deep learning (DL), artificial neural networks (ANNs), and predictive analytics – has considerably accelerated pharmaceutical research by refining decision-making processes, alleviating experimental burden, and enhancing formulation efficiency. The present …

Clinical Significance Of Liver Enzyme Biomarkers In Chronic Statin Users, Muayad Khaleel Ibrahim, Saad Mahmoud Saeed

Al-Esraa University College Journal for Medical Sciences

It is possible that statins, by their dual capacity to modulate (both stimulate and suppress) immune responses, could play a role in influencing the course of autoimmune diseases. Consequently, our investigation was designed to explore how statins impact both the innate and adaptive branches of the immune system, as well as their effect on the crucial mechanism of self-tolerance. This was achieved through the comprehensive measurement of various antibody profiles, specifically including the detection and quantification of autoantibodies, such as antinuclear antibodies and Creatinine kinase, Aldolase, HMGCR antibody, Albumin and Bilirubin and Alanine transaminase, Aspartate aminotransferase, Our investigation employed a …

Crispr/Cas9-Based Genome Editing: Understanding Differences In Dna Repair Pathways, Profiles, And Outcomes, Samuel Effah, Shirley Barrera, Nahia Urturi Ortiz, Will Dampier, Michael Nonnemacher, Brian Wigdahl

Kimmel Cancer Center Faculty Papers

Over a decade of advances in Clustered Regularly Interspersed Short Palindromic Repeats (CRISPR) and CRISPR-associated protein 9 (Cas9)-based technologies have culminated in the first-ever FDA-approved CRISPR/Cas-based therapy. Aside from this approved therapy for sickle cell anemia, several CRISPR/Cas-based therapies are currently under development or testing for a range of chronic diseases, including viral diseases like human immunodeficiency virus type 1 (HIV-1) infection, genetic diseases like familial hypercholesterolemia, and cancer. The success of these therapies hinges on the effective delivery of CRISPR/Cas9 components to target regions, efficient Cas endonuclease editing, repair profiles generated, and their resulting outcomes. Here, we discuss the …

Out-Of-Pocket Health Spending And Household Impoverishment In Tanzania Using The 2020/21 National Panel Survey, John Geofrey Massito Dr, Hinju John Gabriel Dr

Tanzanian Economic Review

Out-of-pocket health spending (OOPHS) can convert healthcare needs into financial hardship, particularly where risk-pooling mechanisms are limited. Evidence on its direct contribution to household impoverishment in Tanzania remains limited. This study estimates the impoverishing effect of OOPHS and examines the factors associated with household exposure to healthcare payments. We analysed nationally representative data from the 2020/21 Tanzania National Panel Survey. Household welfare was assessed before and after OOPHS using the Foster–Greer–Thorbecke poverty framework. Changes in the poverty headcount, poverty gap and poverty severinty were used to identify poverty entry and poverty deepening. Determinants of OOPHS were estimated using a two-part …

Endophytic Actinobacteria: Deciphering Therapeutic And Industrial Potential, And Prospects Of Genome Mining In Novel Products Discovery, Yusra Waheed, Rabia Shahdin, Imran Sajid

Journal of Bioresource Management

Endophytic actinobacteria are a diverse group of Gram-positive bacteria with high G+C content, which inhabit plants’ internal tissues, and represent a significant yet underexplored reservoir of bioactive secondary metabolites. In host plants, a remarkable repertoire of metabolites, including broad-spectrum antibiotics, anticancer, antiviral, antifungal, antioxidant, and immunomodulatory compounds, is synthesized by these microbial allies, carrying significant medicinal and agricultural potential. These endophytes, in contrast to their soil relatives, have developed unique biosynthetic gene clusters (BGCs) strongly influenced by plant-associated factors, leading to the production of structurally novel metabolites. In recent years, the advances in genome mining, metagenomics, and metabolomics have accelerated …

Clinical And Hematological Correlates Of Common Viral Respiratory Infections In Patients With Acute Illness In Iraq, Israa Habeeb Naser

Journal of Bioresource Management

Background: Acute viral respiratory infections are considered as the leading causes of illness and hospitalization worldwide. Influenza virus, Respiratory Syncytial Virus (RSV) and Adenovirus are general respiratory pathogens linked with significant clinical problems in Iraq. This study aims to estimate the prevalence of common respiratory viral infections and their clinical and hematological associations between Iraqi patients with acute-illness.

Methods: This a cross-sectional study was done on 160 patients showing acute febrile and/or respiratory-symptoms. Viral detection for Influenza virus, RSV and Adenovirus was performed using rapid-antigen and ELISA assays. Hematological tests including total leukocyte count (TLC), differential leukocyte count, hemoglobin and …

Detection Of Uropathogenic Multidrug-Resistant Escherichia Coli And Klebsiella Pneumoniae Isolates In Some Immunocompromised Patients., Alaa Abd Atia, Manal Mohammed Kadhim

Al-Qadisiyah Medical Journal

Background: Multidrug-resistant E. coli and K. pneumoniae isolates are the most common causes of acquired urinary tract infections (UTIs). Objective: Conclude the prevalence of multidrug-resistant E. coli and K. pneumoniae isolates in urine samples from immunocompromised patients with UTIs. Methods: A total of 543 urine samples were collected from patients with supposed UTIs. MacConkey, chromogenic agar, and blood culture were used to cultivate the samples. Disk diffusion on Mueller-Hinton agar was used to select cultures that were positive for testing for antibiotic susceptibility. Excel and SPSS software were used to gather and analyze the data. Results: Of …

Extended-Phase Anticoagulation For Pediatric Venous Thromboembolism After Einstein Jr, Nathan Wilken, Jun Teruya

Faculty, Staff and Students Publications

No abstract provided.

Oncocytic Intraductal Carcinoma Of The Parotid Gland With Strn::Alk Fusion, Reham H Soliman, Chris Shi, Kevin E Fisher, Hong Yu, Fouad El-Dana, Xu Cao, Li Liang, Pei Ying, Songlin Zhang

Faculty, Staff and Students Publications

Intraductal carcinoma (IDC) of the salivary gland is an uncommon epithelial neoplasm characterized by a predominantly intraductal or intracystic proliferation rimmed by a myoepithelial cell layer. Advances in molecular profiling have revealed recurrent gene fusions in IDC, most frequently involving RET, although fusions implicating other kinase genes have also been described. Among these, ALK rearrangements are rare and remain poorly characterized. Herein, we report a case of oncocytic IDC of the parotid gland harboring a STRN::ALK fusion, further expanding the molecular landscape of this tumor. Although this fusion has been previously reported in intercalated duct IDC, to our knowledge, this …

Chemotherapeutic Induction Of Cytosolic Single-Stranded Dna Accumulation Sensitizes Triple-Negative Breast Cancer To Immunotherapy, Yong Du, Li Yang, Hui Dai, Jianli Zhou, Zhicheng Zhou, Ruoxi Yuan, Rui Ye, Anh Thai Quynh Nguyen, Kishor Bhatia, Shiaw-Yih Lin

Faculty, Staff and Students Publications

Background: Despite the widespread adoption of chemoimmunotherapy in triple-negative breast cancer (TNBC), the mechanisms by which cytotoxic chemotherapy engages antitumor immunity remain poorly defined. Identifying tumor-intrinsic immunogenic programs that predict and enhance responsiveness to immune checkpoint blockade (ICB) is therefore of critical clinical importance.

Methods: Transcriptomic signatures of TREX1 deficiency were generated from CRISPR-engineered TNBC models and applied to multiple independent TNBC cohorts treated with chemoimmunotherapy. Cytosolic single-stranded DNA (ssDNA) accumulation was quantified using a flow cytometry-based assay to functionally screen chemotherapeutic agents. Immune activation and therapeutic efficacy were evaluated using in vitro assays, syngeneic mouse tumor models, flow cytometry, …

Occupational Therapy’S Role And Impact In Cancer Prehabilitation: A Scoping Review, Abbey Rancour, Averi Haas, Emily Peckham, Kate Reimer, Kylie Mccaskill

Masters Projects

Background:

Oncology prehabilitation aims to optimize patients’ physical and psychosocial function before cancer treatment, yet the specific contributions of occupational therapy (OT) remain underexplored.

Objective:

This scoping review aims to map and synthesize the existing literature describing the role and reported benefits of OT within oncology prehabilitation programs.

Methodology:

Following Arksey and O’Malley’s (2005) scoping review framework and guided by the PRISMA-ScR checklist, three databases (PubMed, CINAHL, and Web of Science) were searched. Search terms included preoperative exercise, prehabilitation, neoplasms, and cancer. Articles were screened by two independent reviewers, and data were charted and analyzed descriptively and thematically.

Results:

A …

Letter To The Editor: Hemodynamic Role In Hepatic Encephalopathy Pathogenesis Following Transjugular Intrahepatic Portosystemic Shunt Placement, John Halphen, Yash S Dayal, Cameron Laurie, Mohadese Ahmadzade, David Wynne, Mohammad Ghasemi-Rad

Faculty, Staff and Students Publications

Hepatic encephalopathy (HE) is a common complication following transjugular intrahepatic portosystemic shunt (TIPS) placement and is thought to result from reduced hepatic detoxification of neurotoxins. However, Zhuang et al in the World Journal of Radiology demonstrate that this understanding may be incomplete through exploration of the pathophysiology from a hemodynamic perspective. They found significant changes in cerebral blood flow (CBF) and spontaneous brain activity following TIPS. Initially, CBF increased in specific areas within the first month, followed by a return to baseline at three months. These CBF changes coincided with increased spontaneous brain activity that persisted in some areas, suggesting …

Surviving Sepsis 2026: Key Updates, Amanda Rawa, Katherine Ghattas

Transformative Medicine

The 2026 update to the Surviving Sepsis Campaign guidelines introduces several important changes in the management of sepsis and septic shock, with a greater focus on tailoring treatment to individual patients. Notable updates include lower blood pressure targets for older adults with septic shock, continued support for early fluid resuscitation, the selective use of rapid diagnostic testing to guide antibiotic therapy, and increased flexibility in vasopressor selection for patients with cardiac dysfunction. These recommendations are based on emerging evidence aimed at improving patient outcomes while reducing unnecessary interventions and treatment-related complications. Overall, the updated guidelines reinforce a more personalized approach …

Online Rights Defense Among Chinese Americans Against Racial Aggression In The U.S. During The Covid-19, Fangzhu Lu, Wenshan Jia

Communication Faculty Articles and Research

Purpose

This study investigates how Chinese American communities responded to heightened racial discrimination during the COVID-19 pandemic by utilizing social media platforms to safeguard their civil rights, articulate collective concerns, and mobilize resistance against racial aggression.

Methodology

Through qualitative case study analysis, the research examines the social media activities of six advocacy organizations, including three X accounts (WashTheHate, Chinese for Affirmative Action, Asian Americans Advancing Justice) and three Instagram accounts (Stop AAPI Hate, Stop Asian Hate, Advancing Justice: AAJC). The analysis focuses on the content strategies and communication mechanisms employed to counteract racial hostility.

Findings

The selected organizations used social …

The Top 50 Cited Articles In Pediatric Neurology: A Bibliometric Analysis, Anas Alyazidi, Osama Muthaffar, Ahmed Bamaga, Hebah Qashqari, Abdulmalek Alhithlool, Ahmad Alanezi, Sameer Almehmadi, Mohamed Babiker, Fahad Bashiri

Neurosciences

Objectives: To identify and analyze the most influential articles within the field of pediatric neurology through a bibliometric lens. As pediatric neurology continues to expand across subspecialties, identifying landmark studies is critical for understanding clinical and research priorities. Bibliometric analysis enables the evaluation of citation trends to highlight impactful contributions that have shaped the field.

Method: A bibliometric analysis of the 50 most-cited pediatric neurology articles was conducted. Articles were assessed by citation metrics, study design, subspecialty, journal impact factor (JIF), and funding status. Correlation and regression analyses evaluated associations between variables.

Results: Citation counts ranged from 185 to 1,440 …

Investigating The Patent Foramen Ovale–Migraine Link In Southern Saudi Arabia, Al-Amir Bassiouny Mohamed, Maeed Alkathiri, Saad Mushabab Ali Alqahtani, Naif H. Ali, Saima Kashif, Saad A. Alshahrani, Mohammed S. Alqahtani, Mohamed Gaber Mahmoud Gabr, Eltohami Zydan Dafalla, Basharat Hameed Zargar, Wael Qenawi, Ali Mohammed A. Alshehri, Fatimah Asiri, Ahmed Borai

Neurosciences

Objective: Migraine is a highly disabling neurological condition, and increasing attention has focused on a possible connection with patent foramen ovale (PFO).

Methods: This single-center observational study enrolled 45 individuals from January to April 2024: 30 migraine patients with PFO (Group 1) and 15 migraine patients without PFO serving as controls (Group 2). All subjects underwent transthoracic echocardiography and completed standardized instruments including the Migraine Disability Assessment (MIDAS), Headache Impact Test (HIT-6), Migraine Symptom Severity Scale (MSSS), Allodynia Symptom Checklist (ASC-12), Visual Aura Rating Scale (VARS), and Migraine Treatment Optimization Questionnaire (mTOQ-6).

Results: The participant's mean age was 37.3 ± …

Syphilis And Hiv Co-Infection Risk Factors At Dr. Moewardi Hospital, 2018–2022: A Retrospective Study, Endra Yustin Ellistasari, Prasetyadi Mawardi, Pratiwi Prasetya Primisawitri, Stella Gracia Octarica

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Treponema pallidum, the agent causing syphilis, is transmitted through contact with infectious lesions, bodily fluids, blood transfusions, or perinatally. Human immunodeficiency virus (HIV) infection can mask the clinical manifestations of syphilis, while syphilis may exacerbate HIV progression. This study aimed to analyze risk factors associated with HIV co-infection among patients with syphilis.

Methods: This retrospective, analytical, observational study reviewed medical records from the Dermatology and Venereology outpatient clinic at Dr. Moewardi Hospital, Surakarta, Indonesia, between January 2018 and December 2022. Demographic, behavioral, and clinical variables were extracted. Univariable analysis was performed using simple binary logistic regression to …

Multi-Modal Survival Prediction On Breast Cancer Mammograms And Enabling Multi-Institutional Collaborations With Federated Learning, Nikolas Koutsoubis

USF Tampa Graduate Theses and Dissertations

Cancer remains one of the leading causes of mortality worldwide, and machine learning is well positioned to leverage the large volumes of routinely collected clinical and imaging data to improve patient outcomes. Realizing this potential at scale requires three capabilities that current practice does not yet deliver in combination: models that integrate the multiple data modalities clinicians use, training procedures that respect institutional data-sharing constraints, and tooling that enables sharing of de-identified data when federated approaches are not sufficient. This dissertation develops methods and infrastructure addressing each of these capabilities in the context of breast cancer and oncology more broadly. …

Instructions To Authors, Academy Editors

Journal of the Arkansas Academy of Science

No abstract provided.

Does Set Configuration Influence Long-Term Adaptations To Complex Training In National-Level Wrestlers? A Volumematched Randomized Trial, Yueqiang Ma, Pengpeng Gou, Yuxiong Huang, Jialiang Yu, Lijia Zhou, Kai Xu, Binbin Jia, Danyang Li

Research outputs 2022 to 2026

Objectives: Complex training is commonly used to enhance strength and explosive performance in athletes; however, the long-term influence of set configuration within complex training remains unclear in highly trained wrestlers. This randomized, volumematched trial investigated whether set configuration influences long-term adaptations to complex training (CT) in national-level male Chinese-style wrestlers. Specifically, the study compared the effects of cluster-set complex training (CS-CT) and traditional-set complex training (TS-CT) on maximal strength, lower-limb explosive performance, anaerobic power, and sport-specific performance.

Methods: Sixteen highly trained wrestlers (Tier 3; n=16) completed an 8-week lowerbody CT program performed twice weekly. Participants were randomly allocated to either …

Vocal Fold Nodules In An 11-Year-Old Boy Treated With An Individualised Homoeopathic Medicine: A Case Report, Shivani Singh, Mahendra Pal Singh

Indian Journal of Research in Homoeopathy

Introduction: Vocal fold nodules (VFNs) are a primary contributor to childhood dysphonia, accounting for about 63% of cases involving voice disturbances. They have a potentially negative impact over the Quality of Life (QoL), including diminished self-esteem and academic performance. The conventional management for voice improvement varies from vocal hygiene and voice therapy to endo-laryngeal microsurgery. This case illustrates the usefulness of Homoeopathy in managing VFNs. Case Summary: An 11-year-old boy presented with a year-long history of painless hoarseness of voice. He was diagnosed with VFNs and underwent extensive conventional treatment, without any improvement. The initial subjective assessment was done using …

Alopecia Totalis Treated With Constitutional Medicine Calcarea Carbonica: A Case Report, Deepak Prasher, Urvashi Diwakar

Indian Journal of Research in Homoeopathy

Introduction: Alopecia totalis is an autoimmune disease that causes hair loss anywhere in the body, but it most commonly affects the hair of the scalp. It occurs in people of all ages and affects 1–2% of the human population. The homoeopathic literature suggests that cases of alopecia totalis have been treated successfully with homoeopathic medicines. Case Summary: This case highlights the potential of the individualised homoeopathic remedy in promoting hair regrowth in alopecia totalis in a 14-yr old girl. The patient was prescribed Calcarea carbonica 200C, 2 doses on the basis of totality of symptoms and individualisation. This evidence-based case …

Nasal Polyp Treated With Homoeopathic Medicine Lemna Minor: An Evidence-Based Case Report, Milan Sengupta, Laijun Nahar, Gurudev Choubey, Chittaranjan Kundu

Indian Journal of Research in Homoeopathy

Introduction: In the general population, nasal polyps (NPs) linked to chronic rhinosinusitis (CRS) are common. Patients with CRS are 60–65% more likely to develop NP. Treatment for NPs resulting from chronic rhino-sinusitis continuous to be challenging. Case summary: A 31-year-old female came with a swelling in her left nostril, clinically diagnosed as a case of NP. Homoeopathic medicine Lemna minor 1M was prescribed based on the acute complaints and pathological symptoms. The swelling was completely resolved within 45 days. This case report demonstrates the usefulness of homoeopathic medicine in the management of NP.

Homoeopathic Treatment Of Multiple Verruca Vulgaris On Dorsal Aspect Of Hands: An Evidence-Based Case Report, Shweta Singh Kureel, Gurpreet Singh, Bharti Wadhwa

Indian Journal of Research in Homoeopathy

Introduction: Verruca vulgaris, widely recognised as warts, are benign epithelial growths with an exophytic nature, typically resulting from infection with the human papillomavirus (HPV). A general cutaneous ailment that can range in severity from a minor annoyance that resolves itself unexpectedly into a long-lasting condition. Homoeopathy aims to concentrate on the fundamental cause of the inherent susceptibility and tendency towards HPV infections by diminishing the size and occurrence of warts and enhancing the body's immune response, thereby minimising the risk of recurrence. Case Summary: A 46-year-old male presented at the outpatient clinic with multiple verruca vulgaris on the dorsal surfaces …

Homoeopathic Treatment Of Chronic, Relapsing Tinea Corporis: A Case Report, Lalit Kumar Chauhan, Shakti Priya

Indian Journal of Research in Homoeopathy

Introduction: Tinea corporis (dermatophysis) is a common dermatophytic infection that affects a significant proportion of the global population, with dermatophytosis accounting for nearly 20–25% of all superficial fungal infections worldwide. Increasing reports of resistance and relapse to conventional antifungal therapy highlight the need for alternative approaches. This case is unique in demonstrating how past history can decisively influence remedy selection in homoeopathic practice, contributing to the exsisting literature on individualised approaches for chronic, relapsing fungal infections. Case Summary: A 35-year-old female presented with multiple erythematous, scaly, pruritic plaques on the back and abdomen, with itching aggravated by sweating and tight …

Indian Standards For Methods Of Preparation Of Homoeopathic Mother Tinctures, Kumar Vivekanand, Daisy Katarmal, Indra Gaurav Saxena, Divya Taneja, Shrishti Dixit, Raj Kumar Manchanda

Indian Journal of Research in Homoeopathy

Homoeopathic mother tinctures form the foundation of homoeopathic pharmaceutical preparations, and their quality largely depends on the source material and the method of extraction. Standardisation of these processes of extraction is essential to ensure consistency, safety, therapeutic reliability, and reproducibility of preparations. The recently published Indian Standards IS 19327 (Part 1): 2025 and IS 19327 (Part 2): 2025 provide standardised procedures for the preparation of homoeopathic mother tinctures through maceration and percolation, respectively. This article reviews the salient features of these standards, including apparatus, materials, procedural steps, process modifications, and storage requirements. The standards emphasise the use of suitable extraction …

Cholelithiasis Treated With Homoeopathy: A Case Report, Girish Gupta

Indian Journal of Research in Homoeopathy

Introduction: The supersaturation of bile with cholesterol, necessary for maintaining bile salts in soluble state, leads to precipitation of cholesterol and other bile components in gallbladder lumen resulting in formation of gall stones. Cholelithiasis is a common digestive disorder that affects about 15% of people over 50 years of age, however in younger individuals it is common between the age of 20–40 years. Gall stones are asymptomatic in about 80% cases, but 1–4% of patients may present with symptoms like pain, nausea and vomiting etc. due to obstruction to bile flow. The treatment of gallbladder stone depends on the clinical …

Management Of Pilar Cyst On The Scalp With Individualised Homoeopathic Medicine: An Evidence-Based Case Report, Anindita Das, Suparja Sinha, Mihir Kanti Biswas

Indian Journal of Research in Homoeopathy

Introduction: Pilar cysts, also referred to as trichilemmal cysts, are benign cystic lesions that commonly occur on the scalp. Conventional management generally involves surgical excision. Homoeopathy provides an individualised, non-invasive therapeutic approach based on the totality of symptoms. Case summary: A 35-year-old female patient presented with a soft, cystic swelling on the scalp associated with itching and tenderness, clinically diagnosed as pilar cyst. Thuja occidentalis was prescribed on the basis of individualisation and a follow-up period of over twelve months showed gradual resolution of the cyst without any surgical intervention, along with improvement in general well-being. The patient was subsequently …

Delicate, Backward, Puny, And Stunted Children By J. Compton Burnett, M.D.- A Book Review, Shreyank Kotian

Indian Journal of Research in Homoeopathy

NA

Individualised Homoeopathic Treatment In Alopecia Areata: An Evidence-Based Case Series, Dinesh Sura, Niharika Shaw, Rubina Bashir, Rahnuma Rao, Ramakrishna Ghosh

Indian Journal of Research in Homoeopathy

Background: Alopecia areata (AA) is an autoimmune disease characterised by hair loss in patches from one or more areas of skin. While it can affect the scalp, it may occur in other parts of the body as well. No age group is predominantly affected. Objective: This case series evaluates the effects of individualised homoeopathic treatment in patients with AA. Method: A total of 5 cases are included in this study. AA was diagnosed based on presentation of clinical symptoms. Two patients improved with Phosphorus. Another two were prescribed Natrium muriaticum and Typhoidinum respectively. One patient improved with Tuberculinum when …