Digital Commons Network^™

Conversation With Henry Spira: Draize Test Activist, Lynne Harriton

Interviews

No abstract provided.

Namru-3 Translations Of Parasite Literature From Russian, French, Japanese, Etc. Into English (1921-1981) T1401-T1500, United States Naval Medical Research Unit Number Three, Cairo, Medical Zoology Department

United States Naval Medical Research Unit 3: Publications

T1401. TRANSLATION FROM RUSSIAN. L'VOV, D. K., GROMASHEVSKY, V. L., SIDOROVA, G. A., TSIRKIN, Yu. M. CHERVONSKY, V. L. GOSTINSHCHIKOVA, G. V. and ARISTOVA, V. A. (1971). Isolation of a new arbovirus Baku of Kemerovo group from argasid ticks Ornithodoros coniceps. in Azerbaijan. Vop. Virus., 16(4):434-437.

T1402. TRANSLATION FROM RUSSIAN. ALEKSANDROV, Yu. V., KORYAGIN, V. L. and YOVAL'CHUK, Zh. T. (1970). Observations on ecological biological properties of Hyalomma plumbeum ticks in eastern Crimea. Tezisy Dokl. 2. Akarol. Soveshch., (1):22-24.

T1403. TRANSLATION FROM RUSSIAN. MATEVOSYAN, K. Sh., KARASEVA, P. S. and SEMENOV, B. F. (1974). Study of potential arbovirus foci in …

Kronos [1981], State University Of New York At Stony Brook, School Of Medicine

Kronos (School of Medicine)

This edition of Kronos, published in 1981, is the official yearbook of the State University of New York at Stony Brook, School of Medicine. Hard-bound.

Role Of The Arachidonic Acid Metabolites, Thromboxane A2 And Prostacyclin, In Shock Induced By Intraabdominal Sepsis, Robert Raymond Butler

MUSC Theses and Dissertations

A rat fecal peritonitis model of acute intraabdominal sepsis was investigated in order to evaluate the potential role of arachidonic acid metabolites in septic shock. Immunoreactive (i) Thromboxane (Tx) B2, the stable metabolite of TXA2' and i6-keto-PGF1α, the stable metabolite of prostacyclin, were measured by radioimmuonassay. plasma levels of iTXB2 rapidly increased from non-detectable (ND< 200 pg/ml) to 1,066 -/+ 194 pg/ml (N=14) 1 hour after feces injection. iTxB2 then increased to 1,695 -/+ 218 pg/ml (N=16) at 4 hours and remained unchanged through 6 hours. Plasma i6-keto-PGF1α increased from ND to 3,777 -/+ 414 pg/ml (N=16) at 1 hour. Four hours after feces, i6-keto-PGF1α levels rose to 6,945 -/+ 732 pg/ml (N=16) then continued to rise to 9,465 -/+ 792 pg/ml (N=7) at 6 hours. Either essential fatty acid deficiency (arachidonic acid depletion) or indomethacin pretreatment (cyclooxygenase inhibition) significantly decreased (P< 0.01) the elevations of plasma iTxB2 and i6-keto-PGF1α associated with fecal peritonitis. Thrombocytopenia occurred within 6 hours after injection of feces and was significantly improved (P< 0.05) by indomethacin. Elevated fibrin degradation products at 6 hours (18 -/+ 3 µg/ml) were significantly reduced in essential fatty acid deficient (7 -/+ 2 µg/ml; P< 0.05) and indomethacin treated (4 -/+ 0.7 µg/ml; P< 0.01) rats. Survival time (8.6 -/+ 0.2 hours) was significantly enhanced by essential fatty acid deficiency (10.2 -/+ 0.4 hrs; P< 0.01) or indomethacin pretreatment (13.3 -/+ 0.6 hrs; P< 0.01). These studies show that fecal peritonitis is associated with increased synthesis of thromboxane A2 and prostacyclin and suggest that these arachidonic acid metabolites may play a role in the pathophysiology of septic shock. To evaluate the pathogenic role of thromboxane (Tx) and prostacyclin (PGI2) in septic shock, the protective efficacy of the Tx synthetase inhibitor, 7(l-imidazolyl) heptanoic acid (7-IHA) and the cyclooxygenase inhibitor, ibuprofen, were assessed during fecal peritonitis in the rat. 7-IHA (60 mg/kg) administered ip 30 minutes prior to feces significantly reduced the plasma level of iTxB2 to ND (P< 0.01) at 1 hour and to 508 -/+ 56 pg/ml (P< 0.01) at 4 hours after injection of feces. In contrast, the levels of i6-keto-PGF1α, the stable metabolite of PGI2 were significantly elevated by 7-IHA pretreatment from septic control levels to 5,185 -/+ 467 pg/ml (P< 0.05) at 1 hour. Plasma i6-keto-PGF1α at 4 hours in 7-IHA treated rats (5,503 -/+ 665 pg/ml) was not different from untreated controls. Ibuprofen (5 mg/kg) administered ip 30 minutes prior to feces significantly decreased both iTxB2 and i6-keto-PGF1α plasma levels to 729 -/+ 99 pg/ml and 1,327 -/+ 251 pg/ml, respectively (P< 0.05) at 4 hours. Survival associated with fecal peritonitis was not altered by 7-IGA pretreatment, but was significantly improved (P< 0.05) in ibuprofen treated rates. Fibrin degradation products were also significantly decreased (P< 0.05) by 7-IHA pretreatment. These results suggest that TxA2 may contribute to the coagulopathies seen in septic shock and that PGI2 may be associated with terminal pathophysiologic events. The final phase of this project investigated the possible synergistic benefit between an antibiotic, gentamicin (GENT), and reduction of arachidonic acid metabolism by pre-administration of indomethacin (INDO) or essential fatty acid (EFA) deficiency. GENT significantly increased mean survival time to 23.8 -/+ 2.6 hours (N=16; P< 0.01). GENT + INDO or GENT + EFA deficiency further improved mean survival time and produced long term survivals (>48 hrs) of 35% (N=17) and 30% (N=7) respectively (P< 0.01 compared to GENT). GENT pretreatment did not significantly alter plasma iTxB2 levels, however, it selectively decreased i6-keto-PGF1α. For example, i6-keto-PGF1α decreased from 9,465 -/+ 792 pg/ml (N=7) to 2,096 -/+ 1174 pg/ml (N=5; P< 0.01) at 6 hours after induction of fecal peritonitis. GENT + INDO pretreatment significantly decreased both iTxB2 and i6-keto-PGF1α to ND (P< 0.01). Pretreatment with GENT alone did not reduce fibrin degradation products. These findings are consistent with the concept that TxA2 may play a role in consumptive coagulopathies and PGI2 may be associated with the terminal hypotension seen during septic shock. The effect of GENT on TxA2 and PGI2 production was investigated further. GENT had no observable effect on in vitro endotoxin stimulated production of these arachidonic acid metabolites by cultured rat peritoneal macrophages. GENT significantly reduced the plasma levels of iTxB2 and i6-keto-PGF1α during endotoxin induced shock in rats. These observations support a complex interaction of bacteria, endotoxin, host tissues, and gentamicin with the possible involvement of undescribed mediated factors.

J Am Coll Dent 1981 48 4

Journal of the American College of Dentists

The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.

An In Vivo Study Of Rabbit Oviductal Motility As Recorded Utilizing A Microminiature Extraluminal Force Transducer, William R. Anderson

MUSC Theses and Dissertations

A microminiature force transducer has been developed and used to record both acutely and chronically the motility of the rabbit reproductive tract. This device, which is comprised of two matched piezoresistive silicon sensors bonded to a titanium beam strip, is durable, physically stable, and highly sensitive to bending forces (gage factor, 140). The reproductive function of 26 rabbits in which two such devices were chronically implanted on the right isthmus was examined in detail. The animals in which these devices were implanted healed quickly with no evidence of infection or other pathological change. No alterations were noted between right (implanted) …

The Effect Of Chronic Ethanol Administration On Organelles Involved In Rna/Protein Synthesis In Mature And Immature Hamster Neurons, Carole R. Dunmire-Graff

Dissertations

No abstract provided.

Vital Signs, January, 1981, Boonshoft School Of Medicine

Vital Signs

An eight page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, a research spotlight, alumni notes, and more.

Temperature Recordings In Neonates, Linda Marie Hestvik

Theses and Dissertations

Summary

The purposes of this ex post facto research study were to answer the following questions:

1. What is the length of time required for glass thermometers to register the temperature in neonates at the rectal and axillary sites?

2. Do significant differences exist between simultaneous axillary and rectal temperature recordings in neonates?

3. What is the relationship between axillary and rectal temperature recordings at specified time intervals in neonates?

A sample of 30, full-term neonates was obtained from the Newborn Nursery of a large teaching hospital in the Middle Atlantic region. All participants were over 24 hours of age …

The Relationship Between Type A Coronary-Prone Behavior Pattern, Achievement, And Life Satisfaction, Larraine A. Felland

Theses and Dissertations

This study examined the relationship between Type A coronary-prone behavior pattern, academic achievement and life satisfaction. The subjects were 87 undergraduates selected for their extreme scores on the Jenkins Activity Survey, Form T. There were 41 Type As and 46 Type Bs. Along with the Jenkins Activity Survey, Form T the participants were administered a life satisfaction survey similar to Soper's (1979) and their official academic gradepoint average was obtained from the Academic Records office. A point-biserial correlation indicated that there was a significant (p

The various relationships and their possible explanations and indications were discussed in depth. Significance of …

Cenobium 1981, Louisiana State University And Agricultural And Mechanical College, School Of Veterinary Medicine, Joanne Maki

Cenobium Yearbook

Cenobium began publication in 1977 and continued through 1990. Produced by students, the yearbooks are a chronicle of the daily life and the special events experienced by veterinary students at the LSU School of Veterinary Medicine.

Commencement Program 1981, Loma Linda University

Commencement Programs

CONTENTS

3 | The President's Greeting

4 | 1981 Events of Commencement

5 | The Academic Procession

6 | The Speakers

9 | The Honorees

11 | Order of Programs

• School of Medicine, 12
• Graduate School, 18
• School of Nursing, 22
• School of Dentistry, 25
• School of Education, 31
• College of Arts and Science, 36
• School of Allied Health Professions, 41
• School of Health, 47

A Strain Gauge Comparison Of Torquing Forces Generated By Orthodontic Archwires, William R. Caryl Jr.

Master's Theses

No abstract provided.

A Study Of The Relationships Between The Admission Criteria And Success/Failure At The Illinois Wesleyan University School Of Nursing, Patty Warters

Honors Projects

Nationwide, the competit i.on to enroll in baccalaureate nursing programs has gradually increased in recent years due to the current number of qualified applicants greatly exceeding the number of spaces available. In most universities the result of, this competition is higher admission requirements ,for incoming students. Wesleyan, other hand, has chosen to lower the admission standards.

Will lowering the criteria affect the percentage of successful nursing graduates? It is this question to which this study discusses why students drop-out of school instead of what can be done to emphasize and discover those factors which contribute to the improvement of the …

Synthesis And Biological Evaluation Of Sparsomycin Analogues, Scherer Preston Sanders

Theses and Dissertations

In 1962, Owen, Dietz, and Camiener reported the isolation of a new antitumor antibiotic from the culture filtrate of Streptomyces sparsogenes. The structure of the crystalline antibiotic, named sparsomycin, remained elusive until 1970, when Wiley and MacKellar reported results of spectroscopic and degradation studies which elucidated the structure. In addition to the molecular structure, investigators have examined the mechanism of action, toxicity, and related analogues, striving to establish sparsomycin or a synthetic analogue's usefulness as an effective chemotherapeutic agent.

The initial pharmacological evaluation of sparsomycin revealed it possessed activity against KB human epidermoid carcinoma cells, a variety of gram-negative and …

Synapsis: Philadelphia Campus (1981), Philadelphia College Of Osteopathic Medicine

All Yearbooks

The 1981 Synapsis includes the Christmas Show, Student Spouses, Christian Medical Society, Lambda Omicron Gamma, LOG, (ΛΟΓ), Phi Sigma Gamma, PSG, (ΦΣΓ), Dinner Dance, Rugby, Volleyball, Student Council, Class Officers, Yearbook Staff.

Isolation Of ��₂-Microglobulin From Miniature Swine Area, Barbara A. Roach

Yale Medicine Thesis Digital Library

No abstract provided.

Health Beliefs And Health Locus Of Control As Predictors Of Cardiorespiratory Endurance In Adults Enrolled In Prescriptive Exercise Programs., Jo Ann Patterson

All ETDs from UAB

No abstract provided.

J Am Coll Dent 1981 48 1

Journal of the American College of Dentists

The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.

Adaptation In Widowhood Among Older Women., Penelope Bradford Paul

All ETDs from UAB

No abstract provided.

Newsletter, Volume 26, Number 01, January - February 1981

Newsletter: A Report to Physicians of Texas Archives

• Cancer Prevention Department Unifies and Defines UT MDAH’s Prevention Efforts
• Noteworthy
• Library Services Keep Researchers Current
• Texas Nutrition and Health Study
• Former Prudential Building Renamed
• 25th Annual Clinical Conference Held
• UT Regents Approve Five New Appointments
• R. Lee Clark Named UT System Professor
• Norah duV. Tapley Dies
• Garth Nicolson Appointed to New Professorship

Comparative In Vitro Studies On Bond Strength And Sealant Polymerization, Gerald E. Sievers

Loma Linda University Electronic Theses, Dissertations & Projects

A comparison of two orthodontic sealants and two adhesives was made. An experimental adhesive was tested (Unitek*) also an experimental sealant (Unitek**) was evaluated for its ability to polymerize into a thin film. An established adhesive and sealant system (Concise***) was compared with the above products.

The factors which were considered important to the study were: the strength of the bond formed; the working efficiency; the ability for these materials to bond to the lingual of teeth; and the value of using contralateral teeth when testing bond strength.

An Instron testing machine was used to record the shear strength of …

In Vitro Percutaneous Penetration Of Methotrexate, Rajaram Vaidyanathan

University of the Pacific Theses and Dissertations

This research project was designed to investigate the effects of various physical and chemical parameters on percutaneous penetration of methotrexate. The potential of propylene glycol in water as a vehicle for topical delivery of methotrexate has been examined. A detailed examination of solubility, partition coefficient and pH parameters in the range of 2 to 6 pH units has been conducted with the goal of correlating their effects on skin penetration of methotrexate. The importance of physiochemical parameters such as solubility and partition coefficient and their aid in the development of a suitable delivery system for topical application has been explained. …

Virginia Dental Journal (Vol. 58, No. 6, 1981)

Virginia Dental Journal

No abstract provided.

Systematic Application Of Behaviorally Oriented Aura Interruption Techniques In Relation To Seizure Control, Charles Stevens Jr.

University of the Pacific Theses and Dissertations

Viewing a seizure as a behavioral chain consisting of a precursor aura phase and a climactic phase has moved researchers to introduce behavioral techniques either singularly or in combination at aura to circumvent seizures. Many of the aura interruption techniques have been shown to be effective in reducing seizure rate, but a systematic examination and application of the technqiues and the additive effects of. combinations have not been explored . The present study examines by way of an A-B-A-B-BC-B-BC single subject design the singular and additive effects of three aura interruption techniques (i.e., startle, shake, and differential reinforcement of other …

An Empirical Verification Of The Johnson Behavioral System Model For Nursing., Nancy Carpano Lovejoy

All ETDs from UAB

No abstract provided.

Studies Toward The Total Synthesis Of Antibiotic 593a, Robert B. Wardle

Undergraduate Honors Capstone Projects

In 1970 art article was published in the Journal of Antibiotics in which the isolation of a substance from the south African soil microorganism Streptomyces griseolutus designated 593A (NSC-135758) was reported. It was reported to inhibit the growth of human tumors in the chick embryo. Arison and Beck in 1973 proposed the structure to be 3,6-bis-(5-chloro-2 -piperidyl-)-2 ,5-piperizinedione based on spectral data.

In the ensuing years a number of further studies were made on the activity of 593A, It was found to be active against a number of solid tumors, several variants of leukemia, and in selectively inhibiting DNA synthesis. …

Audio Biofeedback And Level Of Stress In The Minimally Prepared Gravida During Labor., Sylvia Squires Britt

All ETDs from UAB

No abstract provided.

Protective Effects Of Certain Lythraceae Alkaloids And Homologs In Croton Oil- And Carrageenan-Induced Inflammation, John Alan Byrne

University of the Pacific Theses and Dissertations

Cryogenine's immunosuppressive activity was first evaluated by Kosersky, et al. (21) who, impressed by the drug's ability to inhibit both the irritant- and immune- mediated phases of adjuvant-induced polyarthritis (11), quantitatively confirmed this activity and clearly differentiated the action of cryogenine from that displayed by 6-mercaptopurine. A definitive study by Watson and Malone (22) confirmed cryogenine's lack of immunosuppressive capacity at effective anti-inflammatory dose levels.

The molecular complexity of the lythraceae alkaloids suggests that several active centers may account for their unique pharmacological profile. To assess these potentially active sites, two standard models of acute inflammation were selected for use …

The Effect Of Heparin On Growth Characteristics Of Transplanted Spontaneously Occurring C3h/Hej Mouse Mammary Tumor, Muhammed Saleh Abdullah Banaja

University of the Pacific Theses and Dissertations

Mouse mammary tumor is a common form of cancer used for experimental purposes. It is relatively resistant to chemotherapy. This investigation is designed to test the effect of heparin, a naturally occurring anticoagulant, on tumor growth using a genetically uniform laboratory animal.