Digital Commons Network^™

What's Happening: March 11, 1981, Maine Medical Center

What's Happening

No abstract provided.

The Isolation Of Ecdysterone Inducible Genes By Hybridization Subtraction Chromatography, Michael P. Vitek, Susan G. Kreissman, Robert H. Gross

Dartmouth Scholarship

We have developed a procedure for selectively enriching a mRNA population for inducible sequences. Other than the induced mRNA species, the population of mRNA in control cells is approximately the same as the mRNA population in induced cells. Cytoplasmic mRNA from control cells is bound to oligo (dT)-cellulose and used as a template for reverse transcriptase, the oligo (dT) serving as a primer. After removing the template mRNAs, the cDNA-cellulose column is used to hybridize a population of mRNAs from induced cells. The non-hybridized poly A ⁺ RNAs are greatly enriched in the inducible sequences. We have used this technique …

Clinical Thermoradiotherapy, H. I. Bicher, T. S. Sandhu, F. W. Hetzel

Henry Ford Hospital Medical Journal

A clinical trial is currently in progress to determine the efficacy of combined fractions of hyperthermia and radiation. The protocol consists of two parts. First, four fractions of microwave-induced hyperthermia (45.0° ± 0.5°C) are applied for 1 1/2 hours to the volume encompassing the tumor, each separated by 72 hours. After a one-week rest, a second series of four fractions is administered again at 72- hour intervals. Each fraction consists of a 400 rad dose of radiation followed within 20 minutes by hyperthermia (42.5 ± 0.5°C) for 1 1/2 hours. Currently, we have treated 62 patients with 82 fields with …

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Local Hyperthermia And Radiation: A Biologically-Oriented Clinical Scheduling, G. Arcangeli, A. Cividalli

Henry Ford Hospital Medical Journal

In a series of animal tumor studies, heat was directly delivered into the tumor mass with an interstitial applicator. After hyperthermia (44°-45°C for 45 minutes) or radiation alone (3x10 Gy), only a slight delay in tumor growth was observed, while the combined treatment, either simultaneous or sequential (i.e., heat delivered four hours after irradiation), appeared to be the most effective. The cure rate in the two combined treatment groups was 100%, in contrast to the lack of cure in the first two groups. The simultaneous use of heat and x-ray appeared to be slightly more effective than the sequential schedule; …

Hyperthermia, F. K. Storm

Henry Ford Hospital Medical Journal

This report describes the history of hyperthermia and reviews current forms of treatment at both low (42°-43°C) and higher (<45°C) temperatures. Hyperthermia treatment at low temperatures includes fluid immersion and irrigation, regional perfusion with heated fluids, and electromagnetic radiofrequency waves. Low-temperature hyperthermia has also been combined with radiation therapy and with chemotherapy in recent clinical trials. At higher temperatures, we and other investigators have also had promising, preliminary results in treating tumors safely. With the specialized radiofrequency instrumentation we have developed to apply hyperthermia at any depth without preferential surface tissue heating, further clinical investigation of both superficial and deep internal solid tumors is now possible. Recent data suggest that hyperthermia may be an especially effective form of therapy for larger tumors that resist standard forms of treatment. Clinical trials are now underway to determine the most therapeutic dose/time regimen, to determine toxicity and therapeutic enhancement ratios of combined chemotherapy and x-irradiation with hyperthermia, and to evaluate any changes in the host immune system with such therapies.

Hyperthermic Perfusion 16 Years After Its First Clinical Applications, R. Cavaliere, G. Moricca, F. Di Filippo, L. Aloe, G. Monticelli, F. S. Sartori

Henry Ford Hospital Medical Journal

It is known that above-normal temperatures (42°-42.5°C) provoke selective damage to neoplastic cells. We used heated circulating blood as a method for heat transfer on patients with limb tumors. From October 1964 to December 1979, we treated a total of 198 patients with hyperthermic perfusion for melanoma of the limbs (91), osteosarcoma (57), and soft tissue sarcoma (50). For melanoma patients, the five-year survival rate, excluding Stage IV, was 60%. For patients with soft tissue sarcoma, the five-year survival rates were 53% and 56% for hyperthermic perfusion and hyperthermic antiblastic perfusion. respectively. For 29 patients with osteosarcoma, hyperthermic perfusion was …

Local Microwave Hyperthermia In Cancer Therapy: Preliminary Report, Carlos A. Perez, Walter Kopecky, Robert Baglan, D. Venkata Rao, Richard Johnson

Henry Ford Hospital Medical Journal

This report summarizes our preliminary experience at the Mallinckrodt Institute of Radiology treating 26 patients with metastatic tumors with hyperthermia and irradiation. Patients received 400 rad fractions given every 72 hours (twice weekly) for a total of 2400, 2800, 3200, or 4000 rad followed by hyperthermia. In addition, 18 lesions were treated according to a protocol designed by the Radiation Therapy Oncology Group (RTOG) for superficial measurable tumors to receive three doses of 500 rad followed by hyperthermia (six lesions) or irradiation alone (three doses of 600, 700, or 800 rad) every 72 hours. Hyperthermia was administered with 2450 MHz …

Vital Signs, March 1981, Boonshoft School Of Medicine

Vital Signs

An eight page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

Newsletter, Volume 26, Number 02, March - April 1981, Raymond Alexanian Md, Walter J. Pagel, Diane Culhane

Newsletter: A Report to Physicians of Texas Archives

• New Books Help Pediatric Patients and Their Parents Cope with Cancer
• Eight Patients Receiving Synthetic Interferon
• Center Helps Recovering Cancer Patients
• Routine Machine Solves the Problem of Transfusions for Jehovah’s Witnesses
• Noteworthy
• Treatment for Multiple Myeloma Reviewed, Raymond Alexanian, MD
• Smith Delivers 18th Mike Hogg Lecture, Walter J. Pagel
• 1979 Clinical Conference Book Reviewed, Diane Culhane
• National Large Bowel Cancer Project Holds Workshop

Toward A Seventh-Day Adventist Theology Of Health, Hedrick J. Edwards

Loma Linda University Electronic Theses, Dissertations & Projects

The Seventh-day Adventist Church espouses the Three Angels' Messages of Revelation 14 as its raison d'etre. In its view the special mission of its members is to take these messages to the entire world. Yet about twenty-five percent of the church's financial worth and a much higher percentage of its paid employees are involved in the healthcare enterprise. Does this fact represent a dichotomy in the church's mission, or is it theologically defensible?

This investigation submits that the denomination's involvement in healthcare and training in the healing arts is theologically defensible and does not represent a departure from or a …

Antiphosphocholine Antibodies Found In Normal Mouse Serum Are Protective Against Intravenous Infection With Type 3 Streptococcus Pneumoniae, David E. Briles, Moon Nahm, Kenneth Schroer, Joseph Davie, Phillip Baker, John Kearney, Raul G. Barletta

School of Veterinary and Biomedical Sciences: Faculty Publications

Although it has been clearly demonstrated that antibodies to pneumococcal capsules are protective in both mice and men (1, 2), the protective properties of antibodies to other pneumococcal constituents have been less well investigated. In the present report we describe results indicating that naturally occurring antibodies binding with the phosphocholine (PC) determinant of the pneumococcal cell wall C-carbohydrate (3) are important in the protection of mice from experimental pneumococcal infections.

[Book Review Of] Knowing And Valuing, The Search For Common Roots, Volume Iv Of The Foundations Of Ethics And Its Relationship To Science, Edited By H. Tristram Engelhart, Jr. And Daniel Callahan, Linda Hansen

The Linacre Quarterly

No abstract provided.

[Book Review Of] Genetic Counseling: Facts, Values, And Norms, Edited By Alexander M. Capron Et Al., Michael Green

The Linacre Quarterly

No abstract provided.

Vital Signs, February, 1981, Boonshoft School Of Medicine

Vital Signs

An eight page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, a research spotlight, alumni notes, and more.

Winter 1981, Southwestern Oklahoma State University

The Sig

The Sig Newsletter from the Southwestern Oklahoma State University College of Pharmacy - Winter 1981

Changing Concepts Of Cancer Biology, Diagnosis And Treatment, Robert N. Taub

MCV/Q, Medical College of Virginia Quarterly

Cancer is the number two killer in the United State and will probably account for some 400,000 deaths in 1982. The lung has now achieved the dubious distinction of being the most common site of cancer in men and causes the most deaths. Cancer of the colon and rectum is the second most common cancer in both males and females combined, whereas carcinoma of the breast and uterus predominate in women.

Breast Cancer: An Update, Wade K. Smith

MCV/Q, Medical College of Virginia Quarterly

Breast cancer comprises approximately 13.9% of all cases of malignancy in both sexes and 19% in women, in whom it is the commonest form of cancer. The American Cancer Society estimates that 110,000 women developed breast cancer in 1981, and some 37,100 deaths from the disease occurred. The five-year survival rate has been improving over the past 40 years as shown in Table 1, but patients remain in risk of recurrence indefinitely and survival for ten years is generally accepted as the minimal time period necessary to establish the validity of new therapies.

Recent Advances In Gastorintestinal Cancer, Galen L. Wampler

MCV/Q, Medical College of Virginia Quarterly

Colorectal carcinoma accounts for the majority of all gastrointestinal cancers and is the second leading site of cancer, excluding skin cancers, in overall incidence in the United States. Cancer of the stomach, although decreasing in frequency is still an important cause of morbidity and mortality. Unfortunately, data from large numbers of patients such as can be found in Cancer Patient Survival Report No. 5 show only very modest increases in survival for patients with these diseases in recent years.

Contents

MCV/Q, Medical College of Virginia Quarterly

Table of contents for MCV/Q, Medical College of Virginia Quarterly, 1981, Volume Sixteen, Numbers Three and Four.

1981 Apothecary, Southwestern Oklahoma State University

Apothecary

THE APOTHECARY would like to congratulate the Seniors on the completion of five years of hard work. We have learned much about our profession and accept the challenges of a professional pharmacist - to be leaders in the advancement of our profession.

External Versus Internal Locus Of Control In Longterm Drug Abusers, Heidi Knipe

Theses Digitization Project

No abstract provided.

Outlook Magazine, Summer 1981

Outlook Magazine

No abstract provided.

Outlook Magazine, Autumn 1981

Outlook Magazine

No abstract provided.

Outlook Magazine, Spring 1981

Outlook Magazine

No abstract provided.

Hepatitis B Virus Infection Among Native Inhabitants Of French Polynesia : A Seroepidemiologic And Genetic Analysis, B. Douglas Lewis

Yale Medicine Thesis Digital Library

No abstract provided.

The Chironian Vol. 93 No. 1, New York Medical College

The Chironian

No abstract provided.

The Psychology Of Euthanizing Animals: The Emotional Components, Charles E. Owens, Ricky Davis, Bill Hurt Smith

Human and Animal Bonding Collection

The emotional effects of euthanizing unwanted animals on professional animal control personnel are examined using written statements of and discussions among twenty-six euthanasia technicians at a workshop during a national session of the Animal Control Academy (Tuscaloosa, AL]. Emotional conflicts arise .in significant part from the dilemma that the same public which is responsible for the problem of unwanted animals also has a markedly negative perception of euthanasia, and by extension, of those who perform euthanasia. During discussions, the euthanasia technicians revealed a variety of strategies for coping with feelings of isolation, alienation and sorrow. These included intellectualization, avoidance of …

Ethical Concerns In Primate Use And Husbandry, Ardith A. Eudey

Experimentation Collection

Subsequent to World War II, a dramatic increase occurred in the utilization of nonhuman primates in biomedical and psychological research and industry. At the same time field studies on the ecological and social behavior of natural populations of primates also increased, making possible more realistic assessments of both the behavioral potentiality of primate populations and their conservation status. In spite of the growing body of information indicating the endangered or threatened status of most species, many laboratory workers and planning agencies continue to regard primates as renewable resources, even seeking to bypass protective legislation in habitat countries to obtain them. …

Biomedical Research And Animal Welfare: Traditional Viewpoints And Future Directions, Franklin M. Loew

Experimentation Collection

It has been twenty years since C.P. Snow first presented the concept of "The Two Cultures"; referring to the "culture" of scientists and the "culture" of literary intellectuals (mainly writers), Snow said (1969):

... constantly I felt I was moving among two groups- comparable in intelligence, identical in race, not grossly different in social origin, earning about the same incomes, who had almost ceased to communicate at all, who in intellectual, moral and psychological climate had so little in common ...

In some ways, "Two Cultures" goes far to characterize the current state of affairs surrounding those whose scientific endeavors …